Basic Information

Faculty

• Faculty of Agriculture

Email Address

• Email Address

  ogura.kohei.7xkyoto-u.ac.jp

Professional Memberships

• From Apr. 2014, To Present

  毒素シンポジウム
• From 2022, To Present

  日本応用糖質科学会
• From Jan. 2019, To Present

  日本農芸化学会
• From Apr. 2010, To Present

  日本細菌学会

Academic Degree

• 23 Mar. 2010

  京都大学博士（農学）
• 23 Mar. 2007

  京都大学修士（農学）

Academic Resume (Undergraduate School/Majors)

• 京都大学, 農学部食品生物科学科, 卒業

Research History

• From Apr. 2023, To Present

  Kyoto University, Graduate School of Agriculture, 准教授
• From Apr. 2018, To Mar. 2023

  Kanazawa University, Institute for Frontier Science Initiative, テニュアトラック助教
• From Aug. 2015, To Mar. 2018

  National Center for Global Health and Medicine, Research Institute, 上級研究員

ID,URL

• J-Global ID

  201801017254518601

researchmap URL

• https://researchmap.jp/koheiogura

Research

Research Interests

• genus Streptococcus
• Bacteriology

Research Areas

• Life sciences, Bacteriology

Papers

• GAS-J, a User-Friendly Browser Application for Genome Assembly, emm-Typing, MLST Typing, and Virulence Factor Gene Detection of Streptococcus pyogenes.

  Norihiko Takemoto; Kohei Ogura; Yuan Gao; Rumi Okuno; Masaya Yamaguchi; Yujiro Hirose; Masayuki Ono; Shigetada Kawabata; Tadayoshi Ikebe; Takashi Hamabata; Tohru Miyoshi-Akiyama

  Microbiology and immunology, 20 Apr. 2025, Peer-reviewed, Corresponding author

  
• Extracellular Vesicle Inhibitors Enhance Cholix-Induced Cell Death via Regulation of the JNK-Dependent Pathway

  Kazuya Ozaki; Hiyo Nagahara; Asaka Kawamura; Takashi Ohgita; Sachika Higashi; Kohei Ogura; Hiroyasu Tsutsuki; Sunao Iyoda; Atsushi Yokotani; Toshiyuki Yamaji; Joel Moss; Kinnosuke Yahiro

  Toxins, 29 Aug. 2024, Peer-reviewed

  
• Corrigendum: Comparative genome analysis of three Group A Streptococcus dysgalactiae subsp. equisimilis strains isolated in Japan

  Haruka Ishihara; Kohei Ogura; Van An Nguyen; Tohru Miyoshi-Akiyama; Shigefumi Okamoto; Norihiko Takemoto

  Journal of medical microbiology, 01 Aug. 2021

  
• Prevalence and genomic characterization of Group A Streptococcus dysgalactiae subsp. equisimilis isolated from patients with invasive infections in Toyama prefecture, Japan

  Haruka Ishihara; Kohei Ogura; Tohru Miyoshi-Akiyama; Masahiko Nakamura; Hiroyasu Kaya; Shigefumi Okamoto

  Microbiology and Immunology, 01 Feb. 2020

  
• Effects of quorum sensing-interfering agents, including macrolides and furanone C-30, and an efflux pump inhibitor on nitrosative stress sensitivity in Pseudomonas aeruginosa.

  Shin Suzuki; Yuji Morita; Shota Ishige; Kiyohiro Kai; Kenji Kawasaki; Kazuyuki Matsushita; Kohei Ogura; Tohru Miyoshi-Akiyama; Takeshi Shimizu

  Microbiology (Reading, England), Jun. 2024, Peer-reviewed

  
• Expression, purification and preliminary crystallographic analysis of bacterial transmembrane protein EfeU for iron import.

  Kenji Okumura; Bunzo Mikami; Sayoko Oiki; Kohei Ogura; Wataru Hashimoto

  Protein expression and purification, Jul. 2024, Peer-reviewed

  
• Prediction and causal inference of hyperuricemia using gut microbiota.

  Yuna Miyajima; Shigehiro Karashima; Ren Mizoguchi; Masaki Kawakami; Kohei Ogura; Kazuhiro Ogai; Aoi Koshida; Yasuo Ikagawa; Yuta Ami; Qiunan Zhu; Hiromasa Tsujiguchi; Akinori Hara; Shin Kurihara; Hiroshi Arakawa; Hiroyuki Nakamura; Ikumi Tamai; Hidetaka Nambo; Shigefumi Okamoto

  Scientific reports, 30 Apr. 2024, Peer-reviewed

  
• Impact of gut microbiome on serum IgG4 levels in the general population: Shika-machi super preventive health examination results

  Aoi Koshida; Shigehiro Karashima; Kohei Ogura; Yuna Miyajima; Kazuhiro Ogai; Ren Mizoguchi; Yasuo Ikagawa; Satoshi Hara; Ichiro Mizushima; Hiroshi Fujii; Mitsuhiro Kawano; Hiromasa Tsujiguchi; Akinori Hara; Hiroyuki Nakamura; Shigefumi Okamoto

  Frontiers in Cellular and Infection Microbiology, 16 Oct. 2023, Peer-reviewed

  
• Antimicrobial Susceptibility to 27 Drugs and the Molecular Mechanisms of Macrolide, Tetracycline, and Quinolone Resistance in Gemella sp.

  Michiko Furugaito; Yuko Arai; Yutaka Uzawa; Toshinori Kamisako; Kohei Ogura; Shigefumi Okamoto; Ken Kikuchi

  Antibiotics, 14 Oct. 2023, Peer-reviewed

  
• A multilocus sequence typing method of Staphylococcus aureus DNAs in a sample from human skin

  Hiroka Furuya; Kohei Ogura; Norihiko Takemoto; Shinya Watanabe; Ayaka Yamazaki; Kazuhiro Ogai; Junko Sugama; Shigefumi Okamoto

  Microbiology and Immunology, 13 Aug. 2023, Peer-reviewed, Corresponding author

  
• 誤嚥性肺炎発症を唾液タンパク質から検知することを目標とした,頬粘膜唾液タンパク質採取手法の検討とプロテオミクス解析による評価

  遠藤 真穂; 小倉 康平; 大貝 和裕; 岡本 成史; 真田 弘美; 須釜 淳子

  看護理工学会誌, 2023, Peer-reviewed

  
• Impact of gut microbiome on the renin-aldosterone system: Shika-machi Super Preventive Health Examination results.

  Ren Mizoguchi; Shigehiro Karashima; Yuna Miyajima; Kohei Ogura; Mitsuhiro Kometani; Daisuke Aono; Seigo Konishi; Masashi Demura; Hiromasa Tsujiguchi; Akinori Hara; Hiroyuki Nakamura; Takashi Yoneda; Shigefumi Okamoto; Kenji Satou

  Hypertension research : official journal of the Japanese Society of Hypertension, 06 Jun. 2023, Peer-reviewed

  
• Oral microbiome changes associated with the menstrual cycle in healthy young adult females

  Ayaka Yamazaki; Kohei Ogura; Kana Minami; Kazuhiro Ogai; Tomomi Horiguchi; Shigefumi Okamoto; Kanae Mukai

  Frontiers in Cellular and Infection Microbiology, 31 Mar. 2023, Peer-reviewed

  
• Potential biomarker proteins for aspiration pneumonia detected by shotgun proteomics using buccal mucosa samples: a cross-sectional case-control study.

  Kohei Ogura; Maho Endo; Takashi Hase; Hitomi Negami; Kohsuke Tsuchiya; Takumi Nishiuchi; Takeshi Suzuki; Kazuhiro Ogai; Hiromi Sanada; Shigefumi Okamoto; Junko Sugama

  Clinical proteomics, 09 Mar. 2023, Peer-reviewed, Lead author

  
• Impact of gut microbiome on dyslipidemia in japanese adults: Assessment of the Shika-machi super preventive health examination results for causal inference

  Yuna Miyajima; Shigehiro Karashima; Kazuhiro Ogai; Kouki Taniguchi; Kohei Ogura; Masaki Kawakami; Hidetaka Nambo; Mitsuhiro Kometani; Daisuke Aono; Masashi Demura; Takashi Yoneda; Hiromasa Tsujiguchi; Akinori Hara; Hiroyuki Nakamura; Shigefumi Okamoto

  Frontiers in Cellular and Infection Microbiology, 02 Sep. 2022, Peer-reviewed

  
• Predominance of ST8 and CC1/spa-t1784 methicillin-resistant Staphylococcus aureus isolates in Japan and their genomic characteristics.

  Kohei Ogura; Daiki Kaji; Masakazu Sasaki; Yoshihito Otsuka; Norihiko Takemoto; Tohru Miyoshi-Akiyama; Ken Kikuchi

  Journal of global antimicrobial resistance, Mar. 2022, Peer-reviewed, Lead author

  
• Interspecies Regulation Between Staphylococcus caprae and Staphylococcus aureus Colonized on Healed Skin After Injury.

  Kohei Ogura; Hiroka Furuya; Natsuki Takahashi; Kana Shibata; Maho Endo; Shinya Watanabe; Longzhu Cui; Tohru Miyoshi-Akiyama; Shigefumi Okamoto; Kazuhiro Ogai; Junko Sugama

  Frontiers in microbiology, 2022, Peer-reviewed, Lead author

  
• A novel endoplasmic stress mediator, Kelch domain containing 7B (KLHDC7B), increased Harakiri (HRK) in the SubAB-induced apoptosis signaling pathway.

  Kinnosuke Yahiro; Kohei Ogura; Hiroyasu Tsutsuki; Sunao Iyoda; Makoto Ohnishi; Joel Moss

  Cell death discovery, 19 Nov. 2021, Peer-reviewed

  
• Gravity magnetic resonance imaging measurement of muscle pump change accompanied by aging and posture

  Taiga Fujii; Naoki Ohno; Takuto Sawazaki; Kohei Ogura; Tosiaki Miyati; Junko Sugama

  Japan Journal of Nursing Science, Jul. 2021, Peer-reviewed

  
• Comparative genome analysis of three Group A Streptococcus dysgalactiae subsp. equisimilis strains isolated in Japan.

  Haruka Ishihara; Kohei Ogura; Van An Nguyen; Tohru Miyoshi-Akiyama; Shigefumi Okamoto; Norihiko Takemoto

  Journal of medical microbiology, Mar. 2021, Peer-reviewed, Lead author, Corresponding author

  
• Amplicon-based skin microbiome profiles collected by tape stripping with different adhesive film dressings: a comparative study.

  Kazuhiro Ogai; Kana Shibata; Natsuki Takahashi; Kohei Ogura; Shigefumi Okamoto; Junko Sugama

  BMC microbiology, 18 Feb. 2021, Peer-reviewed

  
• Cell Death Signaling Pathway Induced by Cholix Toxin, a Cytotoxin and eEF2 ADP-Ribosyltransferase Produced by Vibrio cholerae

  Kohei Ogura; Kinnosuke Yahiro; Joel Moss

  Toxins, 24 Dec. 2020, Peer-reviewed, Lead author, Corresponding author

  
• Subtilase cytotoxin induces a novel form of Lipocalin 2, which promotes Shiga-toxigenic Escherichia coli survival

  Kinnosuke Yahiro; Kohei Ogura; Yoshiyuki Goto; Sunao Iyoda; Tatsuya Kobayashi; Hiroki Takeuchi; Makoto Ohnishi; Joel Moss

  Scientific Reports, Dec. 2020, Peer-reviewed

  
• Novel Hyaluronate Lyase Involved in Pathogenicity of Streptococcus dysgalactiae subsp. equisimilis

  Van An Nguyen; Kohei Ogura; Miki Matsue; Norihiko Takemoto; Kanae Mukai; Yukari Nakajima; Thuy Linh Hoang; Yasunori Iwata; Norihiko Sakai; Takashi Wada; Wataru Hashimoto; Shigefumi Okamoto; Hiroshi Ichimura

  Frontiers in Microbiology, 24 Sep. 2020, Peer-reviewed, Corresponding author

  
• Effect of Sub-MICs of Macrolides on the Sensitivity of Pseudomonas aeruginosa to Nitrosative Stress: Effectiveness against P. aeruginosa with and without Multidrug Resistance

  Takeshi Shimizu; Tohru Miyoshi-Akiyama; Kohei Ogura; Shota Murata; Shota Ishige; Kiyohiro Kai; Konosuke Mitsutsuka; Haruyoshi Tomita; Koichi Tanimoto; Akio Matsumoto

  Antimicrobial Agents and Chemotherapy, 27 Jul. 2020, Peer-reviewed

  
• Stability of Skin Microbiome at Sacral Regions of Healthy Young Adults, Ambulatory Older Adults, and Bedridden Older Patients After 2 Years.

  Kazuhiro Ogai; Kohei Ogura; Nozomi Ohgi; Seohui Park; Miku Aoki; Tamae Urai; Satoshi Nagase; Shigefumi Okamoto; Junko Sugama

  Biological research for nursing, 22 Jul. 2020, Peer-reviewed

  
• Skin Physiology and its Microbiome as Factors Associated with the Recurrence of Pressure Injuries

  Kana Shibata; Kazuhiro Ogai; Kohei Ogura; Tamae Urai; Miku Aoki; Defa Arisandi; Natsuki Takahashi; Shigefumi Okamoto; Hiromi Sanada; Junko Sugama

  Biological Research For Nursing, 10 Jul. 2020, Peer-reviewed

  
• Prevalence and Genomic Characterization of Group A Streptococcus Dysgalactiae Subsp. Equisimilis Isolated From Patients With Invasive Infections in Toyama Prefecture, Japan

  Ishihara H; Ogura K; Miyoshi-Akiyama T; Nakamura M; Kaya H; Okamoto S

  Microbiology and Immunology, Feb. 2020, Peer-reviewed, Corresponding author

  
• Pathogenicity characterization of prevalent-type Streptococcus dysgalactiae subsp. equisimilis strains

  Matsue M; Ogura K; Sugiyama H; Miyoshi-Akiyama T; Takemori-Sakai Y; Iwata Y; Wada T; Okamoto S

  Frontiers in Microbiology, Feb. 2020, Peer-reviewed, Corresponding author

  
• Measuring the Antimicrobial Activity of Lauric Acid against Various Bacteria in Human Gut Microbiota Using a New Method

  Miki Matsue; Yumiko Mori; Satoshi Nagase; Yuta Sugiyama; Rika Hirano; Kazuhiro Ogai; Kohei Ogura; Shin Kurihara; Shigefumi Okamoto

  Cell Transplantation, 30 Oct. 2019, Peer-reviewed

  
• RNA sequencing for ligature induced periodontitis in mice revealed important role of S100A8 and S100A9 for periodontal destruction.

  Shogo Maekawa; Satoru Onizuka; Sayaka Katagiri; Masahiro Hatasa; Yujin Ohsugi; Naoki Sasaki; Kazuki Watanabe; Anri Ohtsu; Rina Komazaki; Kohei Ogura; Tohru Miyoshi-Akiyama; Takanori Iwata; Hiroshi Nitta; Yuichi Izumi

  Scientific reports, 11 Oct. 2019, Peer-reviewed

  
• A multilocus sequence typing scheme of Pseudomonas putida for clinical and environmental isolates

  Kohei Ogura; Kayo Shimada; Tohru Miyoshi-Akiyama

  Scientific Reports, 27 Sep. 2019, Peer-reviewed, Lead author, Corresponding author

  
• Cholix toxin, an eukaryotic elongation factor 2 ADP‐ribosyltransferase, interacts with Prohibitins and induces apoptosis with mitochondrial dysfunction in human hepatocytes

  Kinnosuke Yahiro; Kohei Ogura; Yasuhiro Terasaki; Mamoru Satoh; Satoru Miyagi; Mika Terasaki; Eiki Yamasaki; Joel Moss

  Cellular Microbiology, 14 May 2019, Peer-reviewed

  
• Mechanism of inhibition of Shiga-toxigenic Escherichia coli SubAB cytotoxicity by steroids and diacylglycerol analogues

  Kinnosuke Yahiro; Sayaka Nagasawa; Kimitoshi Ichimura; Hiroki Takeuchi; Kohei Ogura; Hiroyasu Tsutsuki; Takeshi Shimizu; Sunao Iyoda; Makoto Ohnishi; Hirotaro Iwase; Joel Moss; Masatoshi Noda

  Cell Death Discovery, 01 Dec. 2018, Peer-reviewed

  
• Pathogenicity Induced by Invasive Infection of Streptococcus dysgalactiae subsp. equisimilis in a Mouse Model of Diabetes

  Kohei Ogura; Kayo Okumura; Yukiko Shimizu; Teruo Kirikae; Tohru Miyoshi-Akiyama

  Frontiers in Microbiology, 21 Sep. 2018, Peer-reviewed, Lead author

  
• Vibrio cholerae Cholix toxin-induced HepG2 cell death is enhanced by tumor necrosis factor-alpha through ROS and intracellular signal-regulated kinases

  Kohei Ogura; Yasuhiro Terasaki; Tohru Miyoshi-Akiyama; Mika Terasaki; Joel Moss; Masatoshi Noda; Kinnosuke Yahiro

  Toxicological Sciences, 13 Jan. 2017, Peer-reviewed, Lead author

  
• Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function

  Naoe T. Nihira; Kohei Ogura; Kouhei Shimizu; Brian J. North; Jinfang Zhang; Daming Gao; Hiroyuki Inuzuka; Wenyi Wei

  Science Signaling, 14 Feb. 2017, Peer-reviewed

  
• The SCF ^β-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis

  Kouhei Shimizu; Hidefumi Fukushima; Kohei Ogura; Evan C. Lien; Naoe Taira Nihira; Jinfang Zhang; Brian J. North; Ailan Guo; Katsuyuki Nagashima; Tadashi Nakagawa; Seira Hoshikawa; Asami Watahiki; Koji Okabe; Aya Yamada; Alex Toker; John M. Asara; Satoshi Fukumoto; Keiichi I. Nakayama; Keiko Nakayama; Hiroyuki Inuzuka; Wenyi Wei

  Science Signaling, 03 Jan. 2017, Peer-reviewed

  
• Complete Genome Sequence and Comparative Genomics of a Streptococcus pyogenes emm3 Strain M3-b isolated from a Japanese Patient with Streptococcal Toxic Shock Syndrome.

  Ogura K; Watanabe S; Kirikae T; Miyoshi-Akiyama T

  Journal of genomics, 2017, Peer-reviewed, Lead author

  
• Subtilase cytotoxin produced by locus of enterocyte effacement‐negative Shiga‐toxigenic Escherichia coli induces stress granule formation

  Hiroyasu Tsutsuki; Kinnosuke Yahiro; Kohei Ogura; Kimitoshi Ichimura; Sunao Iyoda; Makoto Ohnishi; Sayaka Nagasawa; Kazuko Seto; Joel Moss; Masatoshi Noda

  Cellular Microbiology, 21 Feb. 2016, Peer-reviewed

  
• PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex

  Pengda Liu; Wenjian Gan; Y. Rebecca Chin; Kohei Ogura; Jianping Guo; Jinfang Zhang; Bin Wang; John Blenis; Lewis C. Cantley; Alex Toker; Bing Su; Wenyi Wei

  Cancer Discovery, 01 Nov. 2015, Peer-reviewed

  
• DAP1, a Negative Regulator of Autophagy, Controls SubAB-Mediated Apoptosis and Autophagy

  Kinnosuke Yahiro; Hiroyasu Tsutsuki; Kohei Ogura; Sayaka Nagasawa; Joel Moss; Masatoshi Noda

  Infection and Immunity, Nov. 2014, Peer-reviewed

  
• Uptake of Shiga-toxigenicEscherichia coli SubAB by HeLa cells requires an actin- and lipid raft-dependent pathway

  Sayaka Nagasawa; Kohei Ogura; Hiroyasu Tsutsuki; Hisako Saitoh; Joel Moss; Hirotaro Iwase; Masatoshi Noda; Kinnosuke Yahiro

  Cellular Microbiology, 17 Jun. 2014, Peer-reviewed

  
• SCF-Mediated Cdh1 Degradation Defines a Negative Feedback System that Coordinates Cell-Cycle Progression

  Hidefumi Fukushima; Kohei Ogura; Lixin Wan; Ying Lu; Victor Li; Daming Gao; Pengda Liu; Alan W. Lau; Tao Wu; Marc W. Kirschner; Hiroyuki Inuzuka; Wenyi Wei

  Cell Reports, Aug. 2013, Peer-reviewed, Lead author

  
• Degradation of the Transcription Factor Twist, an Oncoprotein that Promotes Cancer Metastasis

  Jiateng Zhong; Kohei Ogura; Zhiwei Wang; Hiroyuki Inuzuka

  Discovery Medicine, Jan. 2013, Peer-reviewed, Lead author

  
• Subtilase Cytotoxin Enhances Escherichia coli Survival in Macrophages by Suppression of Nitric Oxide Production through the Inhibition of NF-kappa B Activation

  Hiroyasu Tsutsuki; Kinnosuke Yahiro; Kotaro Suzuki; Akira Suto; Kohei Ogura; Sayaka Nagasawa; Hideshi Ihara; Takeshi Shimizu; Hiroshi Nakajima; Joel Moss; Masatoshi Noda

  INFECTION AND IMMUNITY, Nov. 2012, Peer-reviewed

  
• Induced-fit motion of a lid loop involved in catalysis in alginate lyase A1-III

  Bunzo Mikami; Mizuho Ban; Sachiko Suzuki; Hye-Jin Yoon; Osamu Miyake; Masayuki Yamasaki; Kohei Ogura; Yukie Maruyama; Wataru Hashimoto; Kousaku Murata

  Acta Crystallographica Section D Biological Crystallography, 18 Aug. 2012, Peer-reviewed

  
• Regulation of Subtilase Cytotoxin-Induced Cell Death by an RNA-Dependent Protein Kinase-Like Endoplasmic Reticulum Kinase-Dependent Proteasome Pathway in HeLa Cells

  Kinnosuke Yahiro; Hiroyasu Tsutsuki; Kohei Ogura; Sayaka Nagasawa; Joel Moss; Masatoshi Noda

  Infection and Immunity, May 2012, Peer-reviewed

  
• Characterization of Cholix Toxin-induced Apoptosis in HeLa Cells

  Kohei Ogura; Kinnosuke Yahiro; Hiroyasu Tsutsuki; Sayaka Nagasawa; Shinji Yamasaki; Joel Moss; Masatoshi Noda

  Journal of Biological Chemistry, Oct. 2011, Peer-reviewed, Lead author

  
• Identification of Subtilase Cytotoxin (SubAB) Receptors Whose Signaling, in Association with SubAB-Induced BiP Cleavage, Is Responsible for Apoptosis in HeLa Cells

  Kinnosuke Yahiro; Mamoru Satoh; Naoko Morinaga; Hiroyasu Tsutsuki; Kohei Ogura; Sayaka Nagasawa; Fumio Nomura; Joel Moss; Masatoshi Noda

  Infection and Immunity, Feb. 2011, Peer-reviewed

  
• Crystal Structure of Family 14 Polysaccharide Lyase with pH-dependent Modes of Action

  Kohei Ogura; Masayuki Yamasaki; Takashi Yamada; Bunzo Mikami; Wataru Hashimoto; Kousaku Murata

  Journal of Biological Chemistry, Dec. 2009, Peer-reviewed, Lead author

  
• Substrate recognition by family 7 alginate lyase from Sphingomonas sp. A1

  Kohei Ogura; Masayuki Yamasaki; Bunzo Mikami; Wataru Hashimoto; Kousaku Murata

  Journal of Molecular Biology, Jul. 2008, Peer-reviewed, Lead author

  
• A Structural Basis for Depolymerization of Alginate by Polysaccharide Lyase Family-7

  Masayuki Yamasaki; Kohei Ogura; Wataru Hashimoto; Bunzo Mikami; Kousaku Murata

  Journal of Molecular Biology, Sep. 2005, Peer-reviewed

  
• Crystallization and preliminary X-ray analysis of alginate lyases A1-II and A1-II′ fromSphingomonassp. A1

  Masayuki Yamasaki; Kohei Ogura; Satoko Moriwaki; Wataru Hashimoto; Kousaku Murata; Bunzo Mikami

  Acta Crystallographica Section F Structural Biology and Crystallization Communications, 12 Feb. 2005, Peer-reviewed

  

Misc.

• 都道府県がん診療連携拠点病院がん相談支援センターで顕著に多かった肺がん相談内容の実態

  小倉 綾子; 清水 真佐子; 竹中 康子; 喜多 誠; 大森 晶子; 岩谷 玲香; 小倉 康平

  日本がん看護学会誌, Mar. 2024, Peer-reviewed

  
• Streptococcus pyogenes Genomics

  Norihiko Takemoto; Kohei Ogura; Shinya Watanabe; Fumito Maruyama

  08 Oct. 2022, Corresponding author

  
• 多様なヒト腸内細菌に対するラウリン酸の抗菌活性に関する新規の測定法(A new measuring method for antimicrobial activity of lauric acid against various human gut microbes)

  松榮 美希; 森 裕美子; 長瀬 賢史; 小倉 康平; 大貝 和裕; 杉山 友太; 平野 里佳; 栗原 新; 岡本 成史

  日本細菌学雑誌, Jan. 2020

  
• 褥瘡再発予防に向けて

  須釜 淳子; 大貝 和裕; 小倉 康平; 浦井 珠恵; 岡本 成史

  日本創傷治癒学会プログラム・抄録集, Dec. 2019

  
• 結紮誘導歯周炎マウスの炎症歯周組織におけるRNAシーケンスを用いた発現変動遺伝子の解析

  前川 祥吾; 鬼塚 理; 片桐 さやか; 佐々木 直樹; 渡辺 数基; 大津 杏理; 駒崎 利奈; 小倉 康平; 秋山 徹; 新田 浩; 和泉 雄一; 岩田 隆紀

  日本歯周病学会会誌, May 2019

  
• LEE-negative STECの産生するSubtilase cytotoxin(SubAB)の毒性阻害薬の検索と阻害機序の解明

  八尋 錦之助; 永澤 明佳; 小倉 康平; 清水 健; 津々木 博康; 伊豫田 淳; 大西 真; 野田 公俊

  日本細菌学雑誌, Feb. 2018

  
• HeLa細胞におけるSubAB誘導性アポトーシスはPERK依存性プロテアソーム経路により制御されている(SubAB-induced apoptosis is regulated by a PERK-dependent proteasome pathway in HeLa cells)

  八尋 錦之助; 津々木 博康; 小倉 康平; 永澤 明佳; 盛永 直子; 野田 公俊; Moss Joel

  日本細菌学雑誌, Feb. 2012

  
• 誤嚥性肺炎発症を検出する宿主側タンパク質マーカーの探索

  小倉 康平; 遠藤 真穂; 長谷 剛志; 土屋 晃介; 鈴木 健之; 大貝 和裕; 岡本 成史

  日本臨床微生物学会雑誌, Dec. 2022

  
• 関東地区において高頻度で分離されたST1/spa-t1784型MRSAのゲノム解析

  小倉 康平; 秋山 徹; 菊池 賢; 加地 大樹; 佐々木 雅一; 大塚 喜人

  日本細菌学雑誌, Feb. 2021

  
• Host response to the subtilase cytotoxin produced by locus of enterocyte effacement‐negative Shiga‐toxigenic Escherichia coli

  Hiroyasu Tsutsuki; Kohei Ogura; Joel Moss; Kinnosuke Yahiro

  Microbiology and Immunology, 29 Sep. 2020, Peer-reviewed

  
• Cholixによる細胞致死機構に関与するCholix新規結合タンパク質の同定と機能解析

  八尋錦之助; 小倉康平; 寺崎泰弘; 佐藤守; 宮城聡; 山崎栄樹

  トキシンシンポジウム予稿集, 28 Jun. 2018

  
• LEE-negative STECの産生するSubtilase cytotoxin(SubAB)の毒性阻害薬の検索と阻害機序の解明

  八尋錦之助; 永澤明佳; 小倉康平; 清水健; 津々木博康; 伊豫田淳; 大西真; 野田公俊

  日本細菌学雑誌(Web), 2018

  
• Investigations of invasive streptococcal infection based on next generation sequencing Japanese Journal of Chemotherapy

  Takemoto N; Ogura K; Watanabe S; Miyoshi-Akiyama T

  Japanese Journal of Chemotherapy, Sep. 2017

  
• LEE-negative STECの産生するSubtilase cytotoxin(SubAB)の毒性阻害薬の検索と阻害機構の解析

  八尋錦之助; 市村公敏; 竹内裕紀; 永澤明佳; 小倉康平; 津々木博康; 伊豫田淳; 大西真; 野田公俊

  トキシンシンポジウム予稿集, 2017

  
• ADP‐リボシル化毒素Cholixの肝臓細胞障害機構の解明

  八尋錦之助; 小倉康平; 寺崎泰弘; 秋山徹; 寺崎美佳; 野田公俊

  日本生化学会大会(Web), 2017

  
• コレラ菌由来ADPリボシル化毒素Cholix toxinによる肝細胞致死機構

  小倉康平; 小倉康平; 寺崎泰弘; 秋山徹; 八尋錦之助; 野田公俊

  トキシンシンポジウム予稿集, 25 Jun. 2016

  
• Severe invasive streptococcal infection by Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis

  Shinya Watanabe; Norihiko Takemoto; Kohei Ogura; Tohru Miyoshi-Akiyama

  Microbiology and Immunology, Jan. 2016, Peer-reviewed

  
• Characterization of Shiga-toxigenic Escherichia coli SubAB uptake pathway in HeLa cells

  永澤明佳; 永澤明佳; 八尋錦之助; 小倉康平; 津々木博康; 野田公俊

  日本細菌学雑誌, 2014

  
• 腸管出血性大腸菌の産生するSubtilase cytotoxin(SubAB)はアクチン及び脂質ラフト依存的に細胞内に取り込まれる

  永澤明佳; 永澤明佳; 小倉康平; 津々木博康; 岩瀬博太郎; 野田公俊; 八尋錦之助

  トキシンシンポジウム予稿集, 2014

  
• 腸管出血性大腸菌の産生するSubtilase cytotoxin(SubAB)の細胞内侵入機序の解析

  永澤明佳; 八尋錦之助; 小倉康平; 津々木博康; 野田公俊; 岩瀬博太郎

  日本法医学雑誌, 2012

  
• 2Da14 Alginate lyase vAL-1(S) shows different modes of action (endo/exotype) in neutral and alkaline pH

  OGURA Kohei; YAMASAKI Masayuki; HASHIDUME Takaya; YAMADA Takashi; MIKAMI Bunzo; HASHIMOTO Wataru; MURATA Kousaku

  日本生物工学会大会講演要旨集, 2009

  

External funds: Kakenhi

• 肝臓・皮膚・腎臓の連関によるレンサ球菌感染症の重症化機構

  Grant-in-Aid for Scientific Research (C)

  Basic Section 49050:Bacteriology-related

  Kanazawa University

  小倉 康平

  From 01 Apr. 2021, To 31 Mar. 2024, Granted

  レンサ球菌;溶血性レンサ球菌;病原因子;流行型;臨床分離株;発現解析;腎臓;皮膚;細菌感染;重症化

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K07002/
• Pathogenic mechanism of cellulitis caused by Streptococcus secondary to lymphedema and its its preventive / palliative care measures

  Grant-in-Aid for Scientific Research (B)

  Basic Section 58050:Fundamental of nursing-related

  Osaka University;Kanazawa University

  岡本 成史

  From 01 Apr. 2021, To 31 Mar. 2025, Granted

  リンパ浮腫;蜂窩織炎;皮膚細菌叢;マウスモデル;モデルマウス;マウス;レンサ球菌;化膿レンサ球菌

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H03221/
• 糖尿病性潰瘍のケア方法創出に向けた基礎研究：エストロゲン作用の治癒メカニズム解明

  Grant-in-Aid for Scientific Research (B)

  Basic Section 58050:Fundamental of nursing-related

  Kanazawa University

  向井 加奈恵

  From 01 Apr. 2021, To 31 Mar. 2025, Granted

  糖尿病性潰瘍;皮膚創傷治癒;エストロゲン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H03219/
• 動物細胞外粘液物質を介した腸内優占菌と宿主との相利共生機構の解明

  Grant-in-Aid for Scientific Research (B)

  Basic Section 38060:Applied molecular and cellular biology-related

  Kyoto University

  橋本 渉

  From 01 Apr. 2021, To 31 Mar. 2024, Granted

  腸内細菌叢;動物宿主;相利共生;ムチン;グリコサミノグリカン;微生物叢;常在機構;膜小胞;プロバイオティクス;Bacteroides;γ-アミノ酪酸

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H02156/
• リンパ管のin vitroモデル構築とリンパ浮腫治療法開発の基礎研究

  Grant-in-Aid for Scientific Research (B)

  Basic Section 58050:Fundamental of nursing-related

  Kanazawa University

  中島 由加里

  From 01 Apr. 2020, To 31 Mar. 2026, Granted

  リンパ管;リンパ浮腫;3次元培養;in vitroモデル;幹細胞;メカニカルストレス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H03959/
• How beta-hemolyitc streptocci SDSE exhibits pathogenicity

  Grant-in-Aid for Scientific Research (C)

  Basic Section 49050:Bacteriology-related

  Kanazawa University

  Kohei Ogura

  From 01 Apr. 2018, To 31 Mar. 2021, Project Closed

  レンサ球菌;病原性;糖尿病;ヒアルロン酸;細菌感染;SDSE;ゲノム解析;病原因子;G群レンサ球菌;C群レンサ球菌;高齢者感染

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K07133/
• Adipose insulin signaling regulated by brain KATP channel

  Grant-in-Aid for Young Scientists (B)

  National Center for Global Health and Medicine

  KOHEI OGURA

  From 01 Apr. 2015, To 31 Mar. 2017, Project Closed

  グルコース取り込み;インスリン応答;KATPチャネル;Akt;脂肪細胞;インスリン;カリウムチャネル

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K18977/
• Elucidation of the mechanism of Cholix cytotoxicity via its receptor.

  Grant-in-Aid for Scientific Research (C)

  Chiba University

  Kinnosuke Yahiro

  From 01 Apr. 2013, To 31 Mar. 2016, Project Closed

  毒素;サイトカイン;受容体;細胞死;エフェクター;細菌;ADP-リボシル化;細胞障害

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25460526/
• 細菌外毒素Cholix toxinの新規受容体の同定と毒性発現における役割

  Grant-in-Aid for Young Scientists (B)

  Chiba University

  小倉 康平

  From 01 Apr. 2012, To 31 Mar. 2013, Discontinued

  Cholix toxin;TNF-α

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790409/
• Elucidation of the pathogenic reinforcement action of enterohemorrhagic Escherichia coli produced SubAB

  Grant-in-Aid for Scientific Research (B)

  Chiba University

  Masatoshi Noda

  From 01 Apr. 2012, To 31 Mar. 2017, Project Closed

  腸管出血性大腸菌;SubAB;小胞体ストレス;一酸化窒素;細胞死;ストレスグラニュール;志賀毒素;酸化ストレス;ｌipid-raft;毒素;オートファジー;取り込み機構;阻害剤;lipid-raft;NO

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24390104/
• Analysis of human cell death mechanism caused by ADP-ribosyltransferase Cholix toxin

  Grant-in-Aid for Young Scientists (B)

  Chiba University

  Kinnosuke YAHIRO

  From 01 Apr. 2010, To 31 Mar. 2012, Project Closed

  ADP-リボシル化毒素;アポトーシス;受容体

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790401/
• 血中尿酸値を上昇させる腸内優占細菌Collinsella aerofaciensの尿酸代謝機構

  Grant-in-Aid for Scientific Research (C)

  Basic Section 38020:Applied microbiology-related

  Kyoto University

  小倉 康平

  From 01 Apr. 2024, To 31 Mar. 2027, Granted

  腸内細菌;血中尿酸値;Collinsella;尿酸代謝

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K08661/
• 糖尿病性潰瘍のケア方法創出に向けた基礎研究：エストロゲン作用の治癒メカニズム解明

  Grant-in-Aid for Scientific Research (B)

  Basic Section 58050:Fundamental of nursing-related

  Kanazawa University

  向井 加奈恵

  From 01 Apr. 2021, To 31 Mar. 2025, Granted

  糖尿病性潰瘍;皮膚創傷治癒;エストロゲン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K21528/
• The onset mechanism of cellulitis caused by streptococci secondary to lymphedema and its preventive and palliative care measures

  Grant-in-Aid for Scientific Research (B)

  Basic Section 58050:Fundamental of nursing-related

  Osaka University;Kanazawa University

  岡本 成史

  From 01 Apr. 2021, To 31 Mar. 2025, Granted

  リンパ浮腫;蜂窩織炎;皮膚細菌叢;ディスバイオーシス;レンサ球菌;マウスモデル;モデルマウス;マウス;化膿レンサ球菌

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K21530/
• リンパ管のin vitroモデル構築とリンパ浮腫治療法開発の基礎研究

  Grant-in-Aid for Scientific Research (B)

  Basic Section 58050:Fundamental of nursing-related

  Kanazawa University

  中島 由加里

  From 01 Apr. 2020, To 31 Mar. 2026, Suspended

  リンパ管;リンパ浮腫;3次元培養;in vitroモデル;幹細胞;メカニカルストレス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K20340/

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Course of Synthetic Biology

  GA33, Spring, Graduate School of Agriculture, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar on Biochemistry and Microbiology

  7317, Fall, Faculty of Agriculture, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Molecular Biotechnology Seminar

  GF08, Spring, Graduate School of Agriculture, 1.5
• From 01 Apr. 2024, To 31 Mar. 2025

  Molecular Biotechnology Seminar

  GF08, Fall, Graduate School of Agriculture, 1.5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course in Molecular Biotechnology

  GG08, Spring, Graduate School of Agriculture, 3
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course in Molecular Biotechnology

  GG08, Fall, Graduate School of Agriculture, 3
• From 01 Apr. 2024, To 31 Mar. 2025

  Laboratory Course in Applied Microbiology

  3167, Fall, Faculty of Agriculture, 3
• From 01 Apr. 2024, To 31 Mar. 2025

  Food Molecular Biology I

  7309, Fall, Faculty of Agriculture, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Course of Applied Microbiology

  GA32, Spring, Graduate School of Agriculture, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar on Biochemistry and Microbiology

  7317, Fall, Faculty of Agriculture, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Laboratory Course in Applied Microbiology

  3167, Fall, Faculty of Agriculture, 3
• From 01 Apr. 2023, To 31 Mar. 2024

  Molecular Biotechnology Seminar2

  GB24, Year-long, Graduate School of Agriculture, 3
• From 01 Apr. 2023, To 31 Mar. 2024

  Molecular Biotechnology Seminar1

  GB23, Year-long, Graduate School of Agriculture, 3
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course in Molecular Biotechnology2

  GC24, Year-long, Graduate School of Agriculture, 6
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course in Molecular Biotechnology1

  GC23, Year-long, Graduate School of Agriculture, 6
• From 01 Apr. 2023, To 31 Mar. 2024

  Food Molecular Biology I

  7309, Fall, Faculty of Agriculture, 2

Administration

Faculty management (title, position)

• From 01 Apr. 2025, To 31 Mar. 2027

  男女共同参画推進委員会　委員
• From 01 Apr. 2023, To 31 Mar. 2025

  国際交流委員会　委員