Basic Information

Faculty

• Faculty of Engineering

Concurrent Affiliation

• Institute for Advanced Study, 物質－細胞統合システム拠点, 連携教授
• Center for the Promotion of Interdisciplinary Education and Research (C-PiER), スーパーグローバルコース 化学系ユニット

Professional Memberships

• 日本細胞外小胞学会
• 日本糖質学会
• 日本バイオマテリアル学会
• 日本DDS学会
• 高分子学会
• 日本化学会

Academic Degree

• 工学修士(九州大学)
• 工学博士(九州大学)

Research History

• From Apr. 2023, To Present

  Kyoto University, Graduate School of Medicine, 特任教授
• From Apr. 2023, To Present

  Kyoto University, Graduate School of Engineering, 名誉教授
• From 2010, To Present

  京都大学工学研究科高分子化学専攻, 教授
• From 2017, To 2018

  ノルウエー Norwegian University of Science and Technology 客員教授
• From 2011, To 2018

  JST-ERATO 秋吉バイオナノトランスポーター 研究総括兼任
• From 2005, To 2007

  東京工業大学精密工学研究所 客員教授
• From 2002

  東京医科歯科大学生体材料工学研究所有機材料分野 教授
• From 1999

  科学技術振興事業団さきがけ研究２１「組織化と機能」研究員兼任
• From 1997

  フランス、ルイ・パスツール大学客員 助教授
• From 1993

  京都大学大学院工学研究科合成・生物化学専攻 助教授
• From 1989

  京都大学工学部高分子化学科 助手
• From 1987

  長崎大学工学部工業化学科 講師
• From 1985

  米国 Purdue大学化学科博士研究員（根岸英一教授）

Language of Instruction

• Japanese

ID,URL

• J-Global ID

  201401023926512100

• External link

  http://www.akiyoshi-lab.jp/

researchmap URL

• https://researchmap.jp/2020Kazunari

Research

Research Interests

• バイオインスパイアード科学
• ドラッグデリバリーシステム
• ワクチン
• エクソソーム、細胞外小胞
• 糖鎖工学
• ナノゲル
• 生体機能高分子

Research Areas

• Nanotechnology/Materials, Polymer chemistry
• Life sciences, Pharmaceuticals - chemistry and drug development
• Nanotechnology/Materials, Biochemistry

Papers

• Antitumor immune response elicited by M2 TAM-specific DDS via C-type lectin CD209b using cholesteryl pullulan nanogel as a protein drug carrier.

  Takaaki Nakatsukasa; Daisuke Muraoka; Situo Deng; Kiyoshi Yasui; Shin-Ichi Sawada; Asako Shimoda; Hirokazu Matsushita; Keitaro Matsumoto; Takeshi Nagayasu; Naozumi Harada; Kazunari Akiyoshi; Hiroaki Ikeda

  Biomaterials science, 17 Mar. 2025

  
• 腫瘍関連マクロファージを標的とした抗原送達に関与する分子の探索

  中司 交明; 村岡 大輔; トウ 思拓; 道津 洋介; 安井 潔; 澤田 晋一; 秋吉 一成; 池田 裕明

  日本癌学会総会記事, Sep. 2021

  
• Polysaccharide-Based Coacervate Microgel Bearing Cationic Peptides That Achieve Dynamic Cell-Membrane Structure Alteration and Facile Cytosolic Infusion of IgGs.

  Junya Michibata; Yoshimasa Kawaguchi; Hisaaki Hirose; Akiko Eguchi; Sayaka Deguchi; Kazuo Takayama; Wei Xu; Takuro Niidome; Yoshihiro Sasaki; Kazunari Akiyoshi; Shiroh Futaki

  Bioconjugate chemistry, 05 Nov. 2024

  
• A Direct Approach for Living Biomembrane Printing on a Nanoparticle.

  Ryosuke Mizuta; Eisuke Kanao; Keigo Ukyo; Shusuke Kuwada; Shin-Ichi Sawada; Yasushi Ishihama; Kazunari Akiyoshi; Yoshihiro Sasaki

  Nano letters, 08 Oct. 2024

  
• Low-frequency CD8+ T cells induced by SIGN-R1+ macrophage-targeted vaccine confer SARS-CoV-2 clearance in mice.

  Daisuke Muraoka; Meng Ling Moi; Osamu Muto; Takaaki Nakatsukasa; Situo Deng; Chieko Takashima; Rui Yamaguchi; Shin-Ichi Sawada; Haruka Hayakawa; Thi Thanh Ngan Nguyen; Yasunari Haseda; Takatoshi Soga; Hirokazu Matsushita; Hiroaki Ikeda; Kazunari Akiyoshi; Naozumi Harada

  NPJ vaccines, 18 Sep. 2024

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• Development of a skeletal muscle sheet with direct reprogramming-induced myoblasts on a nanogel-cross-linked porous freeze-dried gel scaffold in a mouse gastroschisis model.

  Shinta Nagano; Shigehisa Fumino; Tsunao Kishida; Junko Wakao; Yoshiaki Hirohata; Shohei Takayama; Kiyokazu Kim; Kazunari Akiyoshi; Osam Mazda; Tatsuro Tajiri; Shigeru Ono

  Pediatric surgery international, 26 Aug. 2024

  
• 舌筋組織再生へ向けたナノゲル架橋ポーラスゲルの開発

  木下 直哉; 佐々木 善浩; 廣瀬 諒; 丸川 恵理子; 澤田 晋一; 向井 貞篤; 原田 浩之; 秋吉 一成

  日本バイオマテリアル学会大会予稿集, Nov. 2019

  
• 磁性ナノゲルシャペロンによるタンパク質デリバリー

  河崎 陸; 佐々木 善浩; 西村 智貴; 関根 由莉奈; 森田 圭一; 丸川 恵理子; 澤田 晋一; 向井 貞篤; 秋吉 一成

  日本DDS学会学術集会プログラム予稿集, Jun. 2017

  
• 有機-無機ハイブリッドポーラス材料の設計と骨再生医療応用

  藤原 理絵; 橋本 良秀; 丸川 恵理子; 澤田 晋一; 向井 貞篤; 佐々木 善浩; 秋吉 一成

  日本バイオマテリアル学会大会予稿集, Nov. 2015

  
• Effects of the matrix-bounded nanovesicles of high-hydrostatic pressure decellularized tissues on neural regeneration

  Mako Kobayashi; Jun Negishi; Naoki Ishida; Yoshihide Hashimoto; Yoshihiro Sasaki; Kazunari Akiyoshi; Tsuyoshi Kimura; Akio Kishida

  Science and Technology of Advanced Materials, 19 Sep. 2024

  
• Biodegradable thermoresponsive phosphoesters

  Yasuhiko Iwasaki; Shinji Enomoto; Chookaet Wachiralarpphaithoon; Kazunari Akiyoshi

  8th World Biomaterials Congress 2008, 2008

  
• Nanogel-crosslinking hydrogel with chaperone-like activity for tissue engineering

  Kazunari Akiyoshi; Urara Hasegawa; Sayaka Toita; Nobuyuki Morimoto

  8th World Biomaterials Congress 2008, 2008

  
• Self-assembled nanogels of cholesteryl-modified polysaccharides: Effect of the polysaccharide structure on their association characteristics in the dilute and semidilute regimes

  Eric Akiyama; Nobuyuki Morimoto; Piotr Kujawa; Yayoi Ozawa; Françoise M. Winnik; Kazunari Akiyoshi

  Biomacromolecules, Aug. 2007

  
• Nanogel-crosslinked thermo-responsive hydrogels: Synthesis and function

  Takafumi Ohki; Nobuyuki Morimoto; Kimio Kurita; Kazunari Akiyoshi

  Polymer Preprints, Japan, 2006

  
• The structures and dynamics of molecular chaperone-like hydrogel nanoparticles

  Norihiro Inomoto; Hitoshi Endo; Mitsuhiro Shibayama; Urara Hasegawa; Kazunari Akiyoshi

  Polymer Preprints, Japan, 2006

  
• Nanogel-quantum dot complex for live cell imaging

  Sayaka Toita; Urara Hasegawa; Kazunari Akiyoshi

  Polymer Preprints, Japan, 2006

  
• Synthesis and characterization of peptide-conjugated polyphosphoesters

  Shinji Enomoto; Yasuhiko Iwasaki; Kazunari Akiyoshi

  Polymer Preprints, Japan, 2006

  
• Design and function of nanogel-calcium phosphate hybrid nanoparticles

  Setsuko Yamane; Ayae Sugawara; Kazunari Akiyoshi

  Polymer Preprints, Japan, 2006

  
• Biorecognition surface prepared with biomembrane-inspired polymers

  Yasuhiko Iwasaki; Yurika Shinohara; Utae Takami; Kimio Kurita; Kazunari Akiyoshi

  Polymer Preprints, Japan, 2006

  
• DDS by the nanoparticle recognizing unnatural sugars of cell-surface

  Haruki Maie; Yasuhiko Iwasaki; Kazunari Akiyoshi

  Polymer Preprints, Japan, 2006

  
• Antibody immobilized well-defined block copolymer brushes for biorecognition surface

  Ryoko Iwata; Yasuhiko Iwasaki; Kazunari Akiyoshi

  Polymer Preprints, Japan, 2006

  
• Functional anogel as nucleic acid career

  Shin-Ichi Sawada; Hirohito Ayame; Urara Hasegawa; Kazunari Akiyoshi

  Polymer Preprints, Japan, 2006

  
• Design of nanogel crosslinked hydrogels and function as artificial molecular chaperone

  Nobuyuki Morimoto; Kazunari Akiyoshi

  Polymer Preprints, Japan, 2006

  
• Preparation of biomembrane-inspired polymers having sugar moieties

  Yasuhiko Iwasaki; Yurika Shinohara; Kimio Kurita; Kazunari Akiyoshi

  Polymer Preprints, Japan, 2006

  
• Biodegradable hydrogel with nanogel cross-linked structure as artificial extracellular matrix

  Urara Hasegawa; Nobuyuki Morimoto; Kazunari Akiyoshi

  Polymer Preprints, Japan, 2006

  
• Covalent immobilization of antibody on well-defined block polymer brushes

  Ryoko Iwata; Yasuhiko Iwasaki; Kazunari Akiyoshi

  Polymer Preprints, Japan, 2006

  
• Nanogel-inorganic hybrid: Function of calcium phophate hybrid nanoparticles

  Setsuko Yamane; Ayae Sugawara; Kazunari Akiyoshi

  Polymer Preprints, Japan, 2006

  
• Design of new nanogel carrier as protein carrier

  Hirohito Ayame; Wakiko Asayama; Nobuyuki Morimoto; Kazunari Akiyoshi

  Polymer Preprints, Japan, 2006

  
• Design of enzymatic-responsive micelle

  Nobuyuki Morimoto; Kazunari Akiyoshi

  Polymer Preprints, Japan, 2006

  
• Preparation of nanogel-inorganic hybrid materials

  Ayae Sugawara; Setsuko Yamane; Kazunari Akiyoshi

  Polymer Preprints, Japan, 2005

  
• Synthesis and solution properties of hydrophobically modified cluster dextrin

  Yavoi Ozawa; Nobuyuki Morimoto; Shin-Ichi Kitamura; Kazunari Akiyoshi

  Polymer Preprints, Japan, 2005

  
• Design and functional evaluation of new nanogel carrier

  Hirohito Ayame; Urara Hasegawa; Shinichi Sawada; Nobuyuki Morimoto; Kazunari Akiyoshi

  Polymer Preprints, Japan, 2005

  
• Nanogel-crosslinked thermo-rasponsive hydrogels: Synthesis and function

  Takafumi Ohki; Nobuyuki Morimoto; Kimio Kurita; Kazunari Akiyoshi

  Polymer Preprints, Japan, 2005

  
• Synthesis and characterization of porous phosphorylcholine polymer hydrogel cross-linked with methacryloyl-functionalized polyphosphates

  Chookaet Wachiralarpphaithoon; Yasuhiko Iwasaki; Kazunari Akiyoshi

  Polymer Preprints, Japan, 2005

  
• Well-defined block polymer brushes for protein immobilization

  Ryoko Iwata; Yasuhiko Iwasaki; Kazunari Akiyoshi

  Polymer Preprints, Japan, 2005

  
• Nanogel-inorganic hybrid: Synthesis of apatite nanoparticles

  Setsuko Yamane; Ayae Sugawara; Kazunari Akiyoshi

  Polymer Preprints, Japan, 2005

  
• Design and function of nanogel-apatite nanoparticles

  Setsuko Yamane; Ayae Sugawara; Kazunari Akiyoshi

  Polymer Preprints, Japan, 2005

  
• Preparation of MPC polymer-coated nanoparticles reacting to unnatural carbohydrates of a cell surface

  Haruki Maie; Yasuhiko Iwasaki; Kazunari Akiyoshi; Michiko Ohtomi

  Polymer Preprints, Japan, 2005

  
• The structural characteristics and the functional evaluation of nanogel

  Wakiko Asayama; Masaki Takagi; Shin-Ichi Sawada; Nobuyuki Morimoto; Tadashi Narita; Kazunari Akiyoshi

  Polymer Preprints, Japan, 2005

  
• Synthesis and function of maltopentaose-substituted poly(L-lysine)

  Mio Yamazaki; Shin-Ichi Sawada; Nobuyuki Morimoto; Kazunari Akiyoshi

  Polymer Preprints, Japan, 2005

  
• Nanogels of hydrophobized polysaccharides: Structure of polysaccharides

  Eri Akiyama; Nobuyuki Morimoto; Kazunari Akiyoshi

  Polymer Preprints, Japan, 2005

  
• Preparation of porous hydrogels cross-linked with poly(phosphoester) and their enzymatic degradation

  Yasuhiko Iwasaki; Chookaet Wachiralarpphaithoon; Kazunari Akiyoshi

  Polymer Preprints, Japan, 2005

  
• Chaperon-like activity of nanogels and function as protein nano carrier

  Wakiko Asayama; Urara Hasegawa; Shin-Ichi Sawada; Kazunari Akiyoshi

  Polymer Preprints, Japan, 2005

  
• Development of nanogel-inorganic hybrid nanoparticles

  Ayae Sugawara; Setsuko Yamane; Kazunari Akiyoshi

  Polymer Preprints, Japan, 2005

  
• Design of well-defined hydrogels by nanogel engineering

  Nobuyuki Morimoto; Takafumi Ohki; Kimio Kurita; Yasuhiko Iwasaki; Kazunari Akiyoshi

  Polymer Preprints, Japan, 2005

  
• Well-defined block polymer brushes for biorecognition surface

  Ryoko Iwata; Yasuhiko Iwasaki; Kazunari Akiyoshi

  Polymer Preprints, Japan, 2005

  
• Quality and Safety Considerations for Therapeutic Products Based on Extracellular Vesicles.

  Yoshinobu Takakura; Rikinari Hanayama; Kazunari Akiyoshi; Shiroh Futaki; Kyoko Hida; Takanori Ichiki; Akiko Ishii-Watabe; Masahiko Kuroda; Kazushige Maki; Yasuo Miura; Yoshiaki Okada; Naohiro Seo; Toshihide Takeuchi; Teruhide Yamaguchi; Yusuke Yoshioka

  Pharmaceutical research, 07 Aug. 2024

  
• Extracellular Vesicles Comprising Carborane Prepared by a Host Exchanging Reaction as a Boron Carrier for Boron Neutron Capture Therapy.

  Riku Kawasaki; Ayano Oshige; Nanami Kono; Keita Yamana; Hidetoshi Hirano; Yamato Miura; Ryuji Yorioka; Kaori Bando; Anri Tabata; Naoki Yasukawa; Masahiro Sadakane; Yu Sanada; Minoru Suzuki; Takushi Takata; Yoshinori Sakurai; Hiroki Tanaka; Dilimulati Yimiti; Shigeru Miyaki; Nobuo Adachi; Ryosuke Mizuta; Yoshihiro Sasaki; Kazunari Akiyoshi; Yoshihide Hattori; Mitsunori Kirihata; Takeshi Nagasaki; Atsushi Ikeda

  ACS applied materials & interfaces, 06 Aug. 2024

  
• Cationic Glucan Dendrimer Gel-Mediated Local Delivery of Anti-OC-STAMP-siRNA for Treatment of Pathogenic Bone Resorption.

  Kenta Yamamoto; Shin-Ichi Sawada; Satoru Shindo; Shin Nakamura; Young M Kwon; Nazanin Kianinejad; Saynur Vardar; Maria Hernandez; Kazunari Akiyoshi; Toshihisa Kawai

  Gels (Basel, Switzerland), 31 May 2024

  
• Self-assembled anionic nanogels for antigen presenting cells delivery in cancer vaccine

  Risako Miura; Shin-Ich Sawada; Yoshihiro Sasaki; Kazunari Akiyoshi

  Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium, 2019

  
• Magnetic nanogel delivery of transcription factor to adipose-derived stem cell for muscle tissue regeneration

  Onaova Kinoshita; Yoshihiro Sasaki; Riku Kawasaki; Eriko Marukawa; Hiroyuki Harada; Kazunari Akiyoshi

  Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium, 2019

  
• Design of hybrid hydrogels with self-assembled nanogels as cross-linkers: Interaction with proteins and chaperone-like activity

  Morimoto, N; Endo, T; Iwasaki, Y; Akiyoshi, K

  Biomacromolecules, 2005, Peer-reviewed

  
• Enveloped Viral Replica Equipped with Spike Protein Derived from SARS-CoV-2.

  Hiroto Furukawa; Sosuke Nakamura; Ryosuke Mizuta; Kentarou Sakamoto; Hiroshi Inaba; Shin-Ichi Sawada; Yoshihiro Sasaki; Kazunari Akiyoshi; Kazunori Matsuura

  ACS synthetic biology, 17 Jun. 2024

  
• Variable swelling behavior of and drug encapsulation in a maleimide-modified hyaluronic acid nanogel-based hydrogel

  Kohei Yabuuchi; Toru Katsumata; Tsuyoshi Shimoboji; Yoshihide Hashimoto; Tsuyoshi Kimura; Kazunari Akiyoshi; Akio Kishida

  Polymer Journal, 16 Jan. 2024, Peer-reviewed

  
• Biodistribution assessment of cationic pullulan nanogel, a nasal vaccine delivery system, in mice and non-human primates.

  Yoshikazu Yuki; Norihiro Harada; Shin-Ichi Sawada; Yohei Uchida; Rika Nakahashi-Ouchida; Hiromi Mori; Tomoyuki Yamanoue; Tomonori Machita; Masakatsu Kanazawa; Dai Fukumoto; Hiroyuki Ohba; Takashi Miyazaki; Kazunari Akiyoshi; Kohtaro Fujihashi; Hiroshi Kiyono

  Vaccine, 31 Jul. 2023

  
• Comparison of Osteoconductive Ability of Two Types of Cholesterol-Bearing Pullulan (CHP) Nanogel-Hydrogels Impregnated with BMP-2 and RANKL-Binding Peptide: Bone Histomorphometric Study in a Murine Calvarial Defect Model.

  Cangyou Xie; Fatma Rashed; Yosuke Sasaki; Masud Khan; Jia Qi; Yuri Kubo; Yoshiro Matsumoto; Shinichi Sawada; Yoshihiro Sasaki; Takashi Ono; Tohru Ikeda; Kazunari Akiyoshi; Kazuhiro Aoki

  International journal of molecular sciences, 05 Jun. 2023

  
• A Facile Method to Coat Nanoparticles with Lipid Bilayer Membrane: Hybrid Silica Nanoparticles Disguised as Biomembrane Vesicles by Particle Penetration of Concentrated Lipid Layers.

  Ryosuke Mizuta; Fumihito Inoue; Yoshihiro Sasaki; Shin-Ichi Sawada; Kazunari Akiyoshi

  Small (Weinheim an der Bergstrasse, Germany), Mar. 2023

  
• Immunological response of polysaccharide nanogel-incorporating PEG hydrogels in an in vivo diabetic model.

  Tugba Bal; Ismail Can Karaoglu; Fusun Sevval Murat; Esra Yalcin; Yoshihiro Sasaki; Kazunari Akiyoshi; Seda Kizilel

  Journal of biomaterials science. Polymer edition, Oct. 2022

  
• Perforated Hydrogels Consisting of Cholesterol-Bearing Pullulan (CHP) Nanogels: A Newly Designed Scaffold for Bone Regeneration Induced by RANKL-Binding Peptides and BMP-2.

  Cangyou Xie; Michiko Satake-Ozawa; Fatma Rashed; Masud Khan; Masaomi Ikeda; Shunya Hayashi; Shinichi Sawada; Yoshihiro Sasaki; Tohru Ikeda; Yoshiyuki Mori; Kazunari Akiyoshi; Kazuhiro Aoki

  International journal of molecular sciences, 14 Jul. 2022

  
• Self-assembled polysaccharide nanogel delivery system for overcoming tumor immune resistance.

  Daisuke Muraoka; Naozumi Harada; Hiroshi Shiku; Kazunari Akiyoshi

  Journal of controlled release : official journal of the Controlled Release Society, Jul. 2022

  
• Fusogenic Hybrid Extracellular Vesicles with PD-1 Membrane Proteins for the Cytosolic Delivery of Cargos.

  Raga Ishikawa; Shosuke Yoshida; Shin-Ichi Sawada; Yoshihiro Sasaki; Kazunari Akiyoshi

  Cancers, 26 May 2022

  
• Reversible conjugation of biomembrane vesicles with magnetic nanoparticles using a self-assembled nanogel interface: single particle analysis using imaging flow cytometry.

  Ryosuke Mizuta; Yoshihiro Sasaki; Kiyofumi Katagiri; Shin-Ichi Sawada; Kazunari Akiyoshi

  Nanoscale advances, 12 Apr. 2022

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• Cationic-nanogel nasal vaccine containing the ectodomain of RSV-small hydrophobic protein induces protective immunity in rodents.

  Shingo Umemoto; Rika Nakahashi-Ouchida; Yoshikazu Yuki; Shiho Kurokawa; Tomonori Machita; Yohei Uchida; Hiromi Mori; Tomoyuki Yamanoue; Takehiko Shibata; Shin-Ichi Sawada; Kazuya Ishige; Takashi Hirano; Kohtaro Fujihashi; Kazunari Akiyoshi; Yosuke Kurashima; Daisuke Tokuhara; Peter B Ernst; Masashi Suzuki; Hiroshi Kiyono

  NPJ vaccines, 24 Jul. 2023

  
• Augmented effect of fibroblast growth factor 18 in bone morphogenetic protein 2-induced calvarial bone healing by activation of CCL2/CCR2 axis on M2 macrophage polarization.

  Worachat Namangkalakul; Shigenori Nagai; Chengxue Jin; Ken-Ichi Nakahama; Yuki Yoshimoto; Satoshi Ueha; Kazunari Akiyoshi; Kouji Matsushima; Tomoki Nakashima; Masaki Takechi; Sachiko Iseki

  Journal of tissue engineering, 2023

  
• Extraction and Biological Evaluation of Matrix-Bound Nanovesicles (MBVs) from High-Hydrostatic Pressure-Decellularized Tissues

  Mako Kobayashi; Naoki Ishida; Yoshihide Hashimoto; Jun Negishi; Hideki Saga; Yoshihiro Sasaki; Kazunari Akiyoshi; Tsuyoshi Kimura; Akio Kishida

  International Journal of Molecular Sciences, 09 Aug. 2022

  
• Induction of Mucosal IgA-Mediated Protective Immunity Against Nontypeable Haemophilus influenzae Infection by a Cationic Nanogel-Based P6 Nasal Vaccine.

  Rika Nakahashi-Ouchida; Hiromi Mori; Yoshikazu Yuki; Shingo Umemoto; Takashi Hirano; Yohei Uchida; Tomonori Machita; Tomoyuki Yamanoue; Shin-Ichi Sawada; Masashi Suzuki; Kohtaro Fujihashi; Kazunari Akiyoshi; Yuichi Kurono; Hiroshi Kiyono

  Frontiers in immunology, 2022

  
• Cholesterol-Bearing Polysaccharide-Based Nanogels for Development of Novel Immunotherapy and Regenerative Medicine

  Tetsuya Adachi; Yoshiro Tahara; Kenta Yamamoto; Toshiro Yamamoto; Narisato Kanamura; Kazunari Akiyoshi; Osam Mazda

  Gels, 18 Mar. 2024

  
• Preparation of Cholesterol-Modified Hyaluronic Acid Nanogel-Based Hydrogel and the Inflammatory Evaluation Using Macrophage-like Cells

  Kohei Yabuuchi; Mika Suzuki; Chen Liang; Yoshihide Hashimoto; Tsuyoshi Kimura; Kazunari Akiyoshi; Akio Kishida

  Gels, 31 Oct. 2023

  
• Effect of macromolecular assembly of galactoside-conjugated polysaccharides on galactose oxidase activity

  Ikuo Taniguchi; Kazunari Akiyoshi; Junzo Sunamoto

  Macromolecular Chemistry and Physics, 01 Jun. 1999

  
• 骨欠損部の多孔性ナノゲル架橋ハイブリッドゲルによる再生修復と分光学的手法による骨質の評価

  宮本 奈生; 足立 哲也; 田原 義朗; 山本 俊郎; Pezzotti Giuseppe; 秋吉 一成; 松田 修; 金村 成智

  日本歯周病学会会誌, Apr. 2023

  
• Rapid and Highly Efficient Purification of Extracellular Vesicles Enabled by a TiO₂ Hybridized Spongy-like Polymer

  Eisuke Kanao; Koki Ishida; Ryosuke Mizuta; Yuka Li; Koshi Imami; Tetsuya Tanigawa; Yoshihiro Sasaki; Kazunari Akiyoshi; Jun Adachi; Koji Otsuka; Yasushi Ishihama; Takuya Kubo

  Analytical Chemistry, 13 Sep. 2023

  
• Heat-Induced Flower Nanogels of Both Cholesterol End-Capped Poly(N-isopropylacrylamide)s in Water

  Nobuyuki Morimoto; Florence Segui; Xing-Ping Qiu; Kazunari Akiyoshi; Françoise M. Winnik

  Langmuir, 03 Nov. 2021

  
• External force responsible Nanogels for microchip electrophoresis of DNA

  K. Kondo; N. Kaji; S. Toita; K. Akiyoshi; M. Tokeshi; Y. Baba

  12th International Conference on Miniaturized Systems for Chemistry and Life Sciences - The Proceedings of MicroTAS 2008 Conference, 2008, Peer-reviewed

  
• Diversity analysis of exosomes by their glycan profiling for controlling cellular interactions

  Shimoda Asako; Tateno Hiroaki; Akiyoshi Kazunari

  生化学, 25 Apr. 2023

  
• Surface Glycan Profiling of Extracellular Vesicles by Lectin Microarray and Glycoengineering for Control of Cellular Interactions

  Asako Shimoda; Kazunari Akiyoshi

  PHARMACEUTICAL RESEARCH, Apr. 2023

  
• CD63-positive extracellular vesicles are potential diagnostic biomarkers of pancreatic ductal adenocarcinoma

  Haruki Odaka; Keiko Hiemori; Asako Shimoda; Kazunari Akiyoshi; Hiroaki Tateno

  BMC GASTROENTEROLOGY, Mar. 2022

  
• Development and Function of Exosomes as Bio–nanotransporters

  Sawada Shinichi; Shimoda Asako; Sato Yuko; Seo Naohiro; Shiku Hiroshi; Akiyoshi Kazunari

  MEMBRANE, 2015

  
• Intracellular Protein Delivery Using Self-Assembled Amphiphilic Polysaccharide Nanogels

  Asako Shimoda; Shin-ichi Sawada; Kazunari Akiyoshi

  Intracellular Delivery II, 21 May 2014

  
• Carborane bearing pullulan nanogel-boron oxide nanoparticle hybrid for boron neutron capture therapy.

  Riku Kawasaki; Hidetoshi Hirano; Keita Yamana; Hinata Isozaki; Shogo Kawamura; Yu Sanada; Kaori Bando; Anri Tabata; Kouhei Yoshikawa; Hideki Azuma; Takushi Takata; Hiroki Tanaka; Yoshinori Sakurai; Minoru Suzuki; Naoki Tarutani; Kiyofumi Katagiri; Shin-Ichi Sawada; Yoshihiro Sasaki; Kazunari Akiyoshi; Takeshi Nagasaki; Atsushi Ikeda

  Nanomedicine : nanotechnology, biology, and medicine, 21 Feb. 2023

  
• Cycloamylose-based nanocarriers as a nucleic acid delivery system

  Yoshihiro Sasaki; Sayaka Toita; Kazunari Akiyoshi

  Colloid and Interface Science in Pharmaceutical Research and Development, 2014

  
• Evaluation of 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer-coated dressing on surgical wounds

  Osamu Katakura; Nobuyuki Morimoto; Yasuhiko Iwasaki; Kazunari Akiyoshi; Shohei Kasugai

  Journal of Medical and Dental Sciences, 2005, Peer-reviewed

  
• Classification of Extracellular Vesicles Based on Surface Glycan Structures by Spongy-like Separation Media

  Eisuke Kanao; Shuntaro Wada; Hiroshi Nishida; Takuya Kubo; Tetsuya Tanigawa; Koshi Imami; Asako Shimoda; Kaori Umezaki; Yoshihiro Sasaki; Kazunari Akiyoshi; Jun Adachi; Koji Otsuka; Yasushi Ishihama

  Analytical Chemistry, 13 Dec. 2022

  
• Solution property of hydrophobized pullulan conjugated with poly(ethylene oxide) poly(propylene oxide) poly(ethylene oxide) block-copolymer. Formation of nanoparticles and their thermosensitivity

  Shigeru Deguchi; Kazunari Akiyoshi; Junzo Sunamoto

  Macromolecular Rapid Communications, Sep. 1994, Peer-reviewed

  
• Cell separation in microcanal coated with electrically charged phospholipid polymers

  Ito Tomomi; Iwasaki Yasuhiko; Narita Tadashi; Akiyoshi Kazunari; Ishihara Kazuhiko

  Colloids and Surfaces B: Biointerfaces, 15 Mar. 2005

  
• Nano-scale surface modification of a segmented polyurethane with a phospholipid polymer

  Morimoto Nobuyuki; Watanabe Akihiko; Iwasaki Yasuhiko; Akiyoshi Kazunari; Ishihara Kazuhiko

  Biomaterials, 01 Oct. 2004

  
• Novel biodegradable polyphosphate cross-linker for making biocompatible hydrogel

  Iwasaki Yasuhiko; Nakagawa Chigusa; Ohtomi Michiko; Ishihara Kazuhiko; Akiyoshi Kazunari

  Biomacromolecules, 01 May 2004

  
• Biodegradable phosphorylcholine polymer hydrogels cross-linked with vinyl-functionalized polyphosphate

  Iwasaki Yasuhiko; Komatsu Shinpei; Narita Tadashi; Akiyoshi Kazunari; Ishihara Kazuhiko

  Macromolecular Bioscience, 15 May 2003

  
• Nanogel-based delivery system enhances PGE2 effects on bone formation

  Norihiko Kato; Urara Hasegawa; Nobuyuki Morimoto; Yoshitomo Saita; Kazuhisa Nakashima; Yoichi Ezura; Hisashi Kurosawa; Kazunari Akiyoshi; Masaki Noda

  Journal of Cellular Biochemistry, 01 Aug. 2007

  
• Three-Dimensional Culture of Cartilage Tissue on Nanogel-Cross-Linked Porous Freeze-Dried Gel Scaffold for Regenerative Cartilage Therapy: A Vibrational Spectroscopy Evaluation.

  Tetsuya Adachi; Nao Miyamoto; Hayata Imamura; Toshiro Yamamoto; Elia Marin; Wenliang Zhu; Miyuki Kobara; Yoshihiro Sowa; Yoshiro Tahara; Narisato Kanamura; Kazunari Akiyoshi; Osam Mazda; Ichiro Nishimura; Giuseppe Pezzotti

  International journal of molecular sciences, 22 Jul. 2022

  
• 刺激応答性多糖集合体による放出制御

  秋吉 一成; 砂本 順三

  高分子, 1990

  
• 1P324 Functional Membrane Protein Expression and Integration on Lipid Vesicles(Bioengineering, and new biophysical techniques and instrumentation,Oral Presentations)

  NOMURA Shin-ichiro M.; MORITANI Yuki; ASAYAMA Wakiko; MORITA Ikuo; AKIYOSHI Kazunari

  Seibutsu Butsuri, 2007

  
• 1P323 Channel Forming Protein Integrated Vesicle Creation for Molecular Communication(Bioengineering,Poster Presentations)

  MORITANI Yuki; NOMURA Shin-ichiro M.; HIYAMA Satoshi; SUDA Tatsuya; AKIYOSHI Kazunari

  Seibutsu Butsuri, 2007

  
• 3P318 Artificial cells equipped with cellular connection mechanism

  Nomura S.-i.M.; Kaneda M.; Kondoh S.; Nakahama K.; Morita I.; Akiyoshi K.

  Seibutsu Butsuri, 2005

  
• Substitution for Apoprotein of Neocarzinostain by Self-Aggregate of Cholesterol-Bearing Pullulan

  TANIGUCHI Ikuo; FUJIWARA Masashi; AKIYOSHI Kazunari; SUNAMOTO Junzo

  Bull. Chem. Soc. Jpn., 15 Nov. 1998

  
• Evaluation of 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer-coated dressing on surgical wounds

  Katakura Osamu; Morimoto Nobuyuki; Iwasaki Yasuhiko; Akiyoshi Kazunari; Kasugai Shohei

  Journal of medical and dental sciences, Jun. 2005

  
• O/W-Emulsion Stabilized by Eydrophobized Polysaccharide

  FUKUI Hiroki; AKIYOSHI Kazunari; SUNAMOTO Junzo

  Bull. Chem. Soc. Jpn., 15 Dec. 1996

  
• Poly(MPC-co-BMA) Coating Reduces the Adhesion of Candida albicans to Poly(Methyl Methacrylate) Surfaces

  HATSUNO Kunito; MUKOHYAMA Hitoshi; HORIUCHI Sankichi; IWASAKI Yasuhiko; YAMAMOTO Naoki; AKIYOSHI Kazunari; TANIGUCHI Hisashi

  Prosthodont Res. Pract., 01 Jan. 2006

  
• Single-component nanodiscs via the thermal folding of amphiphilic graft copolymers with the adjusted flexibility of the main chain.

  Tomoki Nishimura; Yusuke Hatatani; Mitsuru Ando; Yoshihiro Sasaki; Kazunari Akiyoshi

  Chemical science, 11 May 2022

  
• Glycopeptoid Nanospheres: Glycosylation-Induced Coacervation of Poly(sarcosine)

  Yota Okuno; Tomoki Nishimura; Yoshihiro Sasaki; Kazunari Akiyoshi

  Nanoscale Advances, 2022

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• Theranostic Agent Combining Fullerene Nanocrystals and Gold Nanoparticles for Photoacoustic Imaging and Photothermal Therapy

  Riku Kawasaki; Kosuke Kondo; Risako Miura; Keita Yamana; Hinata Isozaki; Risako Shimada; Shogo Kawamura; Hidetoshi Hirano; Tomoki Nishimura; Naoki Tarutani; Kiyofumi Katagiri; Alexandra Stubelius; Shin-ichi Sawada; Yoshihiro Sasaki; Kazunari Akiyoshi; Atsushi Ikeda

  International Journal of Molecular Sciences, 23 Apr. 2022

  
• Development and single‐particle analysis of hybrid extracellular vesicles fused with liposomes using viral fusogenic proteins

  Raga Ishikawa; Shosuke Yoshida; Shin‐ichi Sawada; Yoshihiro Sasaki; Kazunari Akiyoshi

  FEBS Open Bio, 05 Apr. 2022

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• A solid-in-oil-in-water emulsion: An adjuvant-based immune-carrier enhances vaccine effect

  Yoshiro Tahara; Riko Mizuno; Tomoki Nishimura; Sada-atsu Mukai; Rie Wakabayashi; Noriho Kamiya; Kazunari Akiyoshi; Masahiro Goto

  Biomaterials, Mar. 2022

  
• Distinguishing functional exosomes and other extracellular vesicles as a nucleic acid cargo by the anion-exchange method.

  Naohiro Seo; Junko Nakamura; Tsuguhiro Kaneda; Hiroaki Tateno; Asako Shimoda; Takanori Ichiki; Koichi Furukawa; Jun Hirabayashi; Kazunari Akiyoshi; Hiroshi Shiku

  Journal of extracellular vesicles, Mar. 2022, Peer-reviewed

  
• Cell targetability of liposomes bearing molecular recognition site.

  Sato Toshinori; Akiyoshi Kazunari; Sunamoto Junzo

  Drug Delivery System, 1989

  
• Self-Assembly of Hydrophobized Polysaccharide. Structure of Hydrogel Nanoparticle and Complexation with Organic Compounds.:Structure of Hydrogel Nanoparticle and Complexation with Organic Compounds

  AKIYOSHI Kazunari; DEGUCHI Shigeru; TAJIMA Hitoshi; NISHIKAWA Takehiro; SUNAMOTO Junzo

  Proceedings of the Japan Academy, 1995

  
• Osteogenic Response to Polysaccharide Nanogel Sheets of Human Fibroblasts After Conversion Into Functional Osteoblasts by Direct Phenotypic Cell Reprogramming

  Kei Nakai; Kenta Yamamoto; Tsunao Kishida; Shin-ichiro Kotani; Yoshiki Sato; Satoshi Horiguchi; Hironaka Yamanobe; Tetsuya Adachi; Francesco Boschetto; Elia Marin; Wenliang Zhu; Kazunari Akiyoshi; Toshiro Yamamoto; Narisato Kanamura; Giuseppe Pezzotti; Osam Mazda

  FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 03 Sep. 2021

  
• Manipulating the Morphology of Amphiphilic Graft-Copolymer Assemblies by Adjusting the Flexibility of the Main Chain

  Tomoki Nishimura; Shota Fujii; Kazuo Sakurai; Yoshihiro Sasaki; Kazunari Akiyoshi

  MACROMOLECULES, 27 Jul. 2021

  
• Thermoresponsive Carbohydrate-b-Polypeptoid Polymer Vesicles with Selective Solute Permeability and Permeable Factors for Solutes

  Yota Okuno; Tomoki Nishimura; Yoshihiro Sasaki; Kazunari Akiyoshi

  BIOMACROMOLECULES, Jul. 2021

  
• A nanogel-based trivalent PspA nasal vaccine protects macaques from intratracheal challenge with pneumococci

  Rika Nakahashi-Ouchida; Yohei Uchida; Yoshikazu Yuki; Yuko Katakai; Tomoyuki Yamanoue; Hiromi Ogawa; Yoshiko Munesue; Nozomi Nakano; Kouji Hanari; Takashi Miyazaki; Yuki Saito; Shingo Umemoto; Shin-ichi Sawada; Reshmi Mukerji; David E. Briles; Yasuhiro Yasutomi; Kazunari Akiyoshi; Hiroshi Kiyono

  VACCINE, Jun. 2021

  
• Characterization and Specification of a Trivalent Protein-Based Pneumococcal Vaccine Formulation Using an Adjuvant-Free Nanogel Nasal Delivery System

  Yoshikazu Yuki; Yohei Uchida; Shin-Ichi Sawada; Rika Nakahashi-Ouchida; Kotomi Sugiura; Hiromi Mori; Tomoyuki Yamanoue; Tomonori Machita; Ayaka Honma; Shiho Kurokawa; Reshmi Mukerji; David E. Briles; Kazunari Akiyoshi; Hiroshi Kiyono

  MOLECULAR PHARMACEUTICS, 05 Apr. 2021

  
• Platelet-derived extracellular vesicles are increased in sera of Alzheimer's disease patients, as revealed by Tim4-based assays

  Haruki Odaka; Keiko Hiemori; Asako Shimoda; Kazunari Akiyoshi; Hiroaki Tateno

  FEBS OPEN BIO, Mar. 2021

  
• Murine CD8+T cell EV that prevents tumor metastasis is classified into exosome of late endosome origin

  Naohiro Seo; Junko Nakamura; Tsuguhiro Kaneda; Asako Shimoda; Kazunari Akiyoshi; Hiroshi Shiku

  CANCER SCIENCE, Feb. 2021

  
• Magnetically Navigated Protein Transduction In Vivo using Iron Oxide-Nanogel Chaperone Hybrid

  Riku Kawasaki; Yoshihiro Sasaki; Tomoki Nishimura; Kiyofumi Katagiri; Kei-ichi Morita; Yurina Sekine; Shin-ichi Sawada; Sada-atsu Mukai; Kazunari Akiyoshi

  ADVANCED HEALTHCARE MATERIALS, May 2021

  
• New Lipophilic Fluorescent Dyes for Labeling Extracellular Vesicles: Characterization and Monitoring of Cellular Uptake

  Takashi Shimomura; Ryo Seino; Kaori Umezaki; Asako Shimoda; Takatoshi Ezoe; Munetaka Ishiyama; Kazunari Akiyoshi

  BIOCONJUGATE CHEMISTRY, Apr. 2021

  
• Biocatalytic Hybrid Films Self-Assembled from Carbohydrate Block Copolymers and Polysaccharides for Enzyme Prodrug Therapy

  Tomoki Nishimura; Yusuke Nakamura; Naoya Kinoshita; Katsuhiro Yamamoto; Yoshihiro Sasaki; Kazunari Akiyoshi

  ACS APPLIED BIO MATERIALS, 21 Dec. 2020

  
• Development of Lectin-immobilized Spongy Monoliths for Sub-classification of Exosome

  Takuya Kubo; Seiya Kato; Asako Shimoda; Raga Ishikawa; Shin-ichi Sawada; Yoshihiro Sasaki; Kazunari Akiyoshi; Koji Otsuka

  BUNSEKI KAGAKU, 05 Dec. 2020

  
• Identification of a dominant CD8(+) CTL epitope in the SARS-associated coronavirus 2 spike protein

  Daisuke Muraoka; Deng Situo; Shin-ichi Sawada; Kazunari Akiyoshi; Naozumi Harada; Hiroaki Ikeda

  VACCINE, 17 Nov. 2020

  
• In Vivo Regeneration of Large Bone Defects by Cross-Linked Porous Hydrogel: A Pilot Study in Mice Combining Micro Tomography, Histological Analyses, Raman Spectroscopy and Synchrotron Infrared Imaging

  Tetsuya Adachi; Francesco Boschetto; Nao Miyamoto; Toshiro Yamamoto; Elia Marin; Wenliang Zhu; Narisato Kanamura; Yoshiro Tahara; Kazunari Akiyoshi; Osam Mazda; Ichiro Nishimura; Giuseppe Pezzotti

  MATERIALS, Oct. 2020

  
• Determining the Hydration in the Hydrophobic Layer of Permeable Polymer Vesicles by Neutron Scattering

  Tomoki Nishimura; Liliana de Campo; Hiroki Iwase; Kazunari Akiyoshi

  MACROMOLECULES, 08 Sep. 2020

  
• Preparation of cationic proteoliposomes using cell-free membrane protein synthesis: the chaperoning effect of cationic liposomes

  Mitsuru Ando; Yoshihiro Sasaki; Kazunari Akiyoshi

  RSC ADVANCES, 04 Aug. 2020

  
• Thermoresponsive Polysaccharide Graft Polymer Vesicles with Tunable Size and Structural Memory

  Tomoki Nishimura; Shen Shishi; Yoshihiro Sasaki; Kazunari Akiyoshi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 08 Jul. 2020

  
• Enveloped artificial viral capsids self-assembled from anionic beta-annulus peptide and cationic lipid bilayer

  Hiroto Furukawa; Hiroshi Inaba; Fumihito Inoue; Yoshihiro Sasaki; Kazunari Akiyoshi; Kazunori Matsuura

  CHEMICAL COMMUNICATIONS, 04 Jul. 2020

  
• Crosslinked nanogel-based porous hydrogel as a functional scaffold for tongue muscle regeneration

  Naoya Kinoshita; Yoshihiro Sasaki; Eriko Marukawa; Ryo Hirose; Shin-ichi Sawada; Hiroyuki Harada; Kazunari Akiyoshi

  JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 02 Jul. 2020

  
• Preparation of engineered extracellular vesicles with full-length functional PD-1 membrane proteins by baculovirus expression system

  Raga Ishikawa; Shosuke Yoshida; Shin-ichi Sawada; Yoshihiro Sasaki; Kazunari Akiyoshi

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 11 Jun. 2020

  
• Artificial Molecular Chaperone Systems for Proteins, Nucleic Acids, and Synthetic Molecules

  Tomoki Nishimura; Kazunari Akiyoshi

  BIOCONJUGATE CHEMISTRY, 20 May 2020

  
• Synergistic anti-tumor efficacy by combination therapy of a self-assembled nanogel vaccine with an immune checkpoint anti-PD-1 antibody

  Risako Miura; Shin-ichi Sawada; Sada-atsu Mukai; Yoshihiro Sasaki; Kazunari Akiyoshi

  RSC ADVANCES, 25 Feb. 2020

  
• Antigen Delivery to Antigen-Presenting Cells for Adaptive Immune Response by Self-Assembled Anionic Polysaccharide Nanogel Vaccines

  Risako Miura; Shin-ichi Sawada; Sada-atsu Mukai; Yoshihiro Sasaki; Kazunari Akiyoshi

  BIOMACROMOLECULES, 10 Feb. 2020

  
• Nanogel hybrid assembly for exosome intracellular delivery: effects on endocytosis and fusion by exosome surface polymer engineering

  Shin-ichi Sawada; Yuko T. Sato; Riku Kawasaki; Jun-ichi Yasuoka; Ryosuke Mizuta; Yoshihiro Sasaki; Kazunari Akiyoshi

  BIOMATERIALS SCIENCE, 21 Jan. 2020

  
• Substrate-Sorting Nanoreactors Based on Permeable Peptide Polymer Vesicles and Hybrid Liposomes with Synthetic Macromolecular Channels

  Tomoki Nishimura; Shin Hirose; Yoshihiro Sasaki; Kazunari Akiyoshi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 08 Jan. 2020

  
• Nanogel antigen DDS toward overcoming immune resistance of cancer

  Naozumi Harada; Daisuke Muraoka; Hiroshi Shiku; Kazunari Akiyoshi

  Drug Delivery System, 2020

  
• Exosome surface glycans reflect osteogenic differentiation of mesenchymal stem cells: Profiling by an evanescent field fluorescence-assisted lectin array system

  Asako Shimoda; Shin-ichi Sawada; Yoshihiro Sasaki; Kazunari Akiyoshi

  SCIENTIFIC REPORTS, Aug. 2019

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• Nanogelation and Thermal Stabilization of Enzyme by Vitamin B-6-Bearing Polysaccharide as Biocrosslinker

  Yoshihiro Sasaki; Yuji Tsuchido; Takahiro Yoshimura; Kazunari Akiyoshi

  ACS BIOMATERIALS SCIENCE & ENGINEERING, 11 Nov. 2019, Peer-reviewed

  
• 生体アパタイトの配向性を制御する多孔性ナノゲル架橋ハイブリッドゲルを用いた骨再生

  足立 哲也; 山本 俊郎; 田原 義朗; Pezzotti Giuseppe; 松田 修; 秋吉 一成; 金村 成智

  日本バイオマテリアル学会大会予稿集, Nov. 2019

  
• Supramacromolecular injectable hydrogels by crystallization-driven self-assembly of carbohydrate-conjugated poly(2-isopropyloxazoline)s for biomedical applications

  Tomoki Nishimura; Naoki Sumi; Sada-atsu Mukai; Yoshihiro Sasaki; Kazunari Akiyoshi

  JOURNAL OF MATERIALS CHEMISTRY B, Nov. 2019, Peer-reviewed

  
• Magnetically Navigated Intracellular Delivery of Extracellular Vesicles Using Amphiphilic Nanogels

  Ryosuke Mizuta; Yoshihiro Sasaki; Riku Kawasaki; Kiyofumi Katagiri; Shin-ichi Sawada; Sada-atsu Mukai; Kazunari Akiyoshi

  BIOCONJUGATE CHEMISTRY, 21 Aug. 2019, Peer-reviewed

  
• Staphylococcus aureus-specific IgA antibody in milk suppresses the multiplication of S. aureus in infected bovine udder

  Yuya Nagasawa; Yoshio Kiku; Kazue Sugawara; Aya Hirose; Chiaki Kai; Nana Kitano; Toshihiko Takahashi; Tomonori Nochi; Hisashi Aso; Shin-ichi Sawada; Kazunari Akiyoshi; Tomohito Hayashi

  BMC VETERINARY RESEARCH, 09 Aug. 2019

  
• Osteogenic response of mesenchymal progenitor cells to natural polysaccharide nanogel and atelocollagen scaffolds: A spectroscopic study

  Satoshi Horiguchi; Tetsuya Adachi; Alfredo Rondinella; Francesco Boschetto; Elia Marin; Wenliang Zhu; Yoshiro Tahara; Toshiro Yamamoto; Narisato Kanamura; Kazunari Akiyoshi; Giuseppe Pezzotti; Osam Mazda

  MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, Jun. 2019, Peer-reviewed

  
• Synthesis and function of amphiphilic glucan dendrimers as nanocarriers for protein delivery

  Shigeo Takeda; Tomoki Nishimura; Kaori Umezaki; Akiko Kubo; Michiyo Yanase; Shin-ichi Sawada; Yoshihiro Sasaki; Kazunari Akiyoshi

  BIOMATERIALS SCIENCE, Apr. 2019, Peer-reviewed

  
• Synthesis and self-assembly of carbohydrate-conjugated poly(2-oxazoline)s: Polymer vesicles with molecular permeability towards therapeutic nanofactories

  Tomoki Nishimura; Naoki Sumi; Yuta Koda; Yoshihiro Sasaki; Kazunari Akiyoshi

  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Mar. 2019

  
• Antigen delivery targeted to tumor-associated macrophages overcomes tumor immune resistance

  Daisuke Muraoka; Naohiro Seo; Tae Hayashi; Yoshiro Tahara; Keisuke Fujii; Isao Tawara; Yoshihiro Miyahara; Kana Okamori; Hideo Yagita; Seiya Imoto; Rui Yamaguchi; Mitsuhiro Komura; Satoru Miyano; Masahiro Goto; Shin-ichi Sawada; Akira Asai; Hiroaki Ikeda; Kazunari Akiyoshi; Naozumi Harada; Hiroshi Shiku

  JOURNAL OF CLINICAL INVESTIGATION, Mar. 2019, Peer-reviewed

  
• Magnetic Field Stimuli-Sensitive Drug Release Using a Magnetic Thermal Seed Coated with Thermal-Responsive Molecularly Imprinted Polymer

  Takuya Kubo; Kaname Tachibana; Toyohiro Naito; Sadaatsu Mukai; Kazunari Akiyoshi; Jeyadevan Balachandran; Koji Otsuka

  ACS BIOMATERIALS SCIENCE & ENGINEERING, Feb. 2019, Peer-reviewed

  
• Intrinsically permeable polymer vesicles based on carbohydrate-conjugated poly(2-oxazoline)s synthesized using a carbohydrate-based initiator system

  Tomoki Nishimura; Naoki Sumi; Yuta Koda; Yoshihiro Sasaki; Kazunari Akiyoshi

  POLYMER CHEMISTRY, Feb. 2019, Peer-reviewed

  
• Synthesis and Characterization of Shell-Cross-Linked Glycopolymer Bilayer Vesicles

  Tomoki Nishimura; Wei-Lun Toh; Kazunari Akiyoshi

  MACROMOLECULAR RAPID COMMUNICATIONS, Dec. 2018

  
• Biotransporting Biocatalytic Reactors toward Therapeutic Nanofactories

  Tomoki Nishimura; Kazunari Akiyoshi

  ADVANCED SCIENCE, Nov. 2018

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• Structural effects and lymphocyte activation properties of self-assembled polysaccharide nanogels for effective antigen delivery

  Risako Miura; Yoshiro Tahara; Shin-ichi Sawada; Yoshihiro Sasaki; Kazunari Akiyoshi

  SCIENTIFIC REPORTS, Nov. 2018, Peer-reviewed

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• Proteoliposome Engineering with Cell-Free Membrane Protein Synthesis: Control of Membrane Protein Sorting into Liposomes by Chaperoning Systems

  Mitsuru Ando; Shun Schikula; Yoshihiro Sasaki; Kazunari Akiyoshi

  ADVANCED SCIENCE, Oct. 2018

  
• Exosome-mediated regulation of tumor immunology

  Naohiro Seo; Kazunari Akiyoshi; Hiroshi Shiku

  CANCER SCIENCE, Oct. 2018

  
• Nanogel tectonic porous 3D scaffold for direct reprogramming fibroblasts into osteoblasts and bone regeneration

  Yoshiki Sato; Kenta Yamamoto; Satoshi Horiguchi; Yoshiro Tahara; Kei Nakai; Shin-ichiro Kotani; Fumishige Oseko; Giuseppe Pezzotti; Toshiro Yamamoto; Tsunao Kishida; Narisato Kanamura; Kazunari Akiyoshi; Osam Mazda

  SCIENTIFIC REPORTS, Oct. 2018, Peer-reviewed

  
• PEGylated amphiphilic block copolymers as membrane anchors for controlled affinity to lipid bilayer membranes

  Yuta Koda; Daiki Takahashi; Yoshihiro Sasaki; Kazunari Akiyoshi

  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2018

  
• Design and synthesis of PEGylated amphiphilic block oligomers as membrane anchors for stable binding to lipid bilayer membranes

  Daiki Takahashi; Yuta Koda; Yoshihiro Sasaki; Kazunari Akiyoshi

  POLYMER JOURNAL, Aug. 2018

  
• Sequential Coating of Insulin Secreting Beta Cells within Multilayers of Polysaccharide Nanogels

  Tugba Bal; Dilem Ceren Oran; Yoshihiro Sasaki; Kazunari Akiyoshi; Seda Kizilel

  MACROMOLECULAR BIOSCIENCE, May 2018

  
• Intranasal vaccination against angiotensin II type 1 receptor and pneumococcal surface protein A attenuates hypertension and pneumococcal infection in rodents

  Tatsuhiko Azegami; Yoshikazu Yuki; Kaori Hayashi; Akihito Hishikawa; Shin-ichi Sawada; Kazuya Ishige; Kazunari Akiyoshi; Hiroshi Kiyono; Hiroshi Itoh

  JOURNAL OF HYPERTENSION, Feb. 2018

  
• The improvement of calvarial bone healing by durable nanogel-crosslinked materials

  Pornkawee Charoenlarp; Arun Kumar Rajendran; Rie Fujihara; Taisei Kojima; Ken-ichi Nakahama; Yoshihiro Sasaki; Kazunari Akiyoshi; Masaki Takechi; Sachiko Iseki

  JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 2018

  
• Induced Antigen Presentation by Tumor-Associated Macrophages Enhances Infiltration of CD8+T Cells with Low PD-1 Level

  Naozumi Harada; Daisuke Muraoka; Kazunari Akiyoshi; Hiroshi Shiku

  CANCER SCIENCE, Jan. 2018

  
• Activated CD8(+) T cell extracellular vesicles prevent tumour progression by targeting of lesional mesenchymal cells

  Naohiro Seo; Yoshitaka Shirakura; Yoshiro Tahara; Fumiyasu Momose; Naozumi Harada; Hiroaki Ikeda; Kazunari Akiyoshi; Hiroshi Shiku

  NATURE COMMUNICATIONS, Jan. 2018, Peer-reviewed

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• Self-Assembled Polypeptide Nanogels with Enzymatically Transformable Surface as a Small Interfering RNA Delivery Platform

  Tomoki Nishimura; Akina Yamada; Kaori Umezaki; Shin-ichi Sawada; Sada-atsu Mukai; Yoshihiro Sasaki; Kazunari Akiyoshi

  BIOMACROMOLECULES, Dec. 2017, Peer-reviewed

  
• Nanogel-based nasal ghrelin vaccine prevents obesity.

  T Azegami; Y Yuki; S Sawada; M Mejima; K Ishige; K Akiyoshi; H Itoh; H Kiyono

  Mucosal immunology, Sep. 2017

  
• Biotransporting Self-Assembled Nanofactories Using Polymer Vesicles with Molecular Permeability for Enzyme Prodrug Cancer Therapy

  Tomoki Nishimura; Yoshihiro Sasaki; Kazunari Akiyoshi

  ADVANCED MATERIALS, Sep. 2017, Peer-reviewed

  
• Glycan profiling analysis using evanescent-field fluorescence-assisted lectin array: Importance of sugar recognition for cellular uptake of exosomes from mesenchymal stem cells

  Asako Shimoda; Yoshiro Tahara; Shin-ichi Sawada; Yoshihiro Sasaki; Kazunari Akiyoshi

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Sep. 2017, Peer-reviewed

  
• 黄色ブドウ球菌死菌を抗原とした鼻腔粘膜感作による乳房炎防除効果

  長澤 裕哉; 菊 佳男; 菅原 和恵; 甲斐 千暁; 澤田 晋一; 秋吉 一成; 林 智人

  日本獣医学会学術集会講演要旨集, Aug. 2017

  
• Calcium-deficient Hydroxyapatite as a Potential Sorbent for Strontium

  Yurina Sekine; Ryuhei Motokawa; Naofumi Kozai; Toshihiko Ohnuki; Daiju Matsumura; Takuya Tsuji; Riku Kawasaki; Kazunari Akiyoshi

  SCIENTIFIC REPORTS, May 2017

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• Self-assembled Nanogels of Carborane-bearing Polysaccharides for Boron Neutron Capture Therapy

  Riku Kawasaki; Yoshihiro Sasaki; Kazunari Akiyoshi

  CHEMISTRY LETTERS, Apr. 2017

  
• Effects of a polysaccharide nanogel-crosslinked membrane on wound healing

  Hiroki Maeda; Hiroshi Kobayashi; Takayuki Miyahara; Yoshihide Hashimoto; Kazunari Akiyoshi; Shohei Kasugai

  JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, Apr. 2017

  
• Nanogel-Integrated pH-Responsive Composite Hydrogels for Controlled Drug Delivery

  Gunce E. Cinay; Pelin Erkoc; Mohammad Alipour; Yoshihide Hashimoto; Yoshihiro Sasaki; Kazunari Akiyoshi; Seda Kizilel

  ACS Biomaterials Science & Engineering, 13 Mar. 2017

  
• Antigen delivery targeting tumor-infiltrating macrophages leads to eradication of tumor highly resistant to immune checkpoint inhibitors

  Daisuke Muraoka; Naozumi Harada; Naohiro Seo; Tae Hayashi; Keisuke Fujii; Rui Yamaguchi; Seiya Imoto; Satoru Miyano; Hideo Yagita; Kazunari Akiyoshi; Hiroshi Shiku

  CANCER IMMUNOLOGY RESEARCH, Mar. 2017

  
• Amylose engineering: phosphorylase-catalyzed polymerization of functional saccharide primers for glycobiomaterials

  Tomoki Nishimura; Kazunari Akiyoshi

  WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, Mar. 2017

  
• Intracellular delivery and passive tumor targeting of a self-assembled nanogel containing carborane clusters for boron neutron capture therapy

  Riku Kawasaki; Yoshihiro Sasaki; Kazunari Akiyoshi

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jan. 2017

  
• Self-assembled nanogel of cholesterol-bearing xyloglucan as a drug delivery nanocarrier

  Shin-ichi Sawada; Hiroko Yukawa; Shigeo Takeda; Yoshihiro Sasaki; Kazunari Akiyoshi

  JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 2017, Peer-reviewed

  
• ナノゲル架橋マイクロスフェアの設計と機能

  秋吉 一成; 田原 義朗; 澤田 晋一; 向井 貞篤; 佐々木 善浩

  日本化学繊維研究所講演集 Annual report of the Research Institute for Chemical Fibers, Japan, Jan. 2017

  
• Nanoscopic Structural Investigation of Physically Cross-Linked Nanogels Formed from Self-Associating Polymers

  Yurina Sekine; Hitoshi Endo; Hiroki Iwase; Shigeo Takeda; Sada-atsu Mukai; Hiroshi Fukazawa; Kenneth C. Littrell; Yoshihiro Sasaki; Kazunari Akiyoshi

  JOURNAL OF PHYSICAL CHEMISTRY B, Nov. 2016, Peer-reviewed

  
• Self-Assembled Nanogels of Cholesterol-Bearing Hydroxypropyl Cellulose: A Thermoresponsive Building Block for Nanogel Tectonic Materials

  Yoshiro Tahara; Mizuki Sakiyama; Shigeo Takeda; Tomoki Nishimura; Sada-atsu Mukai; Shin-ichi Sawada; Yoshihiro Sasaki; Kazunari Akiyoshi

  LANGMUIR, Nov. 2016, Peer-reviewed

  
• Mouthguard biosensor with telemetry system for monitoring of saliva glucose: A novel cavitas sensor

  Takahiro Arakawa; Yusuke Kuroki; Hiroki Nitta; Prem Chouhan; Koji Toma; Shin-ichi Sawada; Shuhei Takeuchi; Toshiaki Sekita; Kazunari Akiyoshi; Shunsuke Minakuchi; Kohji Mitsubayashi

  BIOSENSORS & BIOELECTRONICS, Oct. 2016

  
• Saccharide Recognition Based on Self-assembly of Amphiphilic Phenylboronic Acid Azoprobes

  Yuji Tsuchido; Ryo Sato; Nana Nodomi; Takeshi Hashimoto; Kazunari Akiyoshi; Takashi Hayashita

  Langmuir, 22 Sep. 2016, Peer-reviewed

  
• Cell-sized asymmetric lipid vesicles facilitate the investigation of asymmetric membranes

  Koki Kamiya; Ryuji Kawano; Toshihisa Osaki; Kazunari Akiyoshi; Shoji Takeuchi

  NATURE CHEMISTRY, Sep. 2016

  
• Magnetically Guided Protein Transduction by Hybrid Nanogel Chaperones with Iron Oxide Nanoparticles

  Riku Kawasaki; Yoshihiro Sasaki; Kiyofumi Katagiri; Sada-atsu Mukai; Shin-ichi Sawada; Kazunari Akiyoshi

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Sep. 2016, Peer-reviewed

  
• Guanine-Rich Sequences Are a Dominant Feature of Exosomal microRNAs across the Mammalian Species and Cell Types

  Fumiyasu Momose; Naohiro Seo; Yasushi Akahori; Shin-ichi Sawada; Naozumi Harada; Toru Ogura; Kazunari Akiyoshi; Hiroshi Shiku

  PLOS ONE, Apr. 2016

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• Advanced Artificial Extracellular Matrices Using Amphiphilic Nanogel-Cross-Linked Thin Films To Anchor Adhesion Proteins and Cytokines

  Yoshihide Hashimoto; Sada-atsu Mukai; Shin-ichi Sawada; Yoshihiro Sasaki; Kazunari Akiyoshi

  ACS BIOMATERIALS SCIENCE & ENGINEERING, Mar. 2016, Peer-reviewed

  
• Liposome chaperon in cell-free membrane protein synthesis: One-step preparation of KcsA-integrated liposomes and electrophysiological analysis by the planar bilayer method

  M. Ando; M. Ando; M. Akiyama; D. Okuno; M. Hirano; M. Hirano; T. Ide; S. Sawada; S. Sawada; Y. Sasaki; K. Akiyoshi; K. Akiyoshi

  Biomaterials Science, Feb. 2016, Peer-reviewed

  
• Engineering hybrid exosomes by membrane fusion with liposomes

  Yuko T. Sato; Kaori Umezaki; Shinichi Sawada; Sada-atsu Mukai; Yoshihiro Sasaki; Naozumi Harada; Hiroshi Shiku; Kazunari Akiyoshi

  SCIENTIFIC REPORTS, Feb. 2016, Peer-reviewed

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• Formation and Function of Nanogels by Self-Assembly of Associating Graft Copolymers

  Yuta Koda; Yoshihiro Sasaki; Kazunari Akiyoshi

  KOBUNSHI RONBUNSHU, 2016

  
• Nanogel containing electrospun nanofibers as a platform for stable loading of proteins

  Asako Shimoda; Yong Chen; Kazunari Akiyoshi

  RSC ADVANCES, 2016

  
• Direct Measurement of Gaseous Formaldehyde from Food with a Fiber-Optic Biochemical Gas Sensor (Bio-sniffer)

  Koji Toma; Kumiko Miyajima; Shin-ichi Sawada; Takahiro Arakawa; Hiroyuki Kudo; Kazunari Akiyoshi; Kohji Mitsubayashi

  SENSORS AND MATERIALS, 2016

  
• Exosomes as nanocarriers for systemic delivery of the Helicobacter pylori virulence factor CagA

  Asako Shimoda; Koji Ueda; Shin Nishiumi; Naoko Murata-Kamiya; Sada-atsu Mukai; Shin-ichi Sawada; Takeshi Azuma; Masanori Hatakeyama; Kazunari Akiyoshi

  SCIENTIFIC REPORTS, Jan. 2016, Peer-reviewed

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• A light sensitive self-assembled nanogel as a tecton for protein patterning materials

  Tomoki Nishimura; Masahiro Takara; Sada-atsu Mukai; Shin-ichi Sawada; Yoshihiro Sasaki; Kazunari Akiyoshi

  CHEMICAL COMMUNICATIONS, 2016, Peer-reviewed

  
• Current advances in self-assembled nanogel delivery systems for immunotherapy

  Yoshiro Tahara; Kazunari Akiyoshi

  ADVANCED DRUG DELIVERY REVIEWS, Dec. 2015, Peer-reviewed

  
• Comprehensive study of liposome-assisted synthesis of membrane proteins using a reconstituted cell-free translation system

  Tatsuya Niwa; Yoshihiro Sasaki; Eri Uemura; Shugo Nakamura; Minato Akiyama; Mitsuru Ando; Shinichi Sawada; Sada-atu Mukai; Takuya Ueda; Hideki Taguchi; Kazunari Akiyoshi

  SCIENTIFIC REPORTS, Dec. 2015, Peer-reviewed

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• Simple Preparation and Characterization of Viscoelastic Gels Induced by Multiple Intermolecular Interactions Using Low-Molecular-Weight Species

  Takuya Kubo; Kenta Kuroda; Toyohiro Naito; Sada-atsu Mukai; Tomoharu Sano; Kazunari Akiyoshi; Koji Otsuka

  BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, Nov. 2015, Peer-reviewed

  
• Nanogel-based pneumococcal surface protein A nasal vaccine induces microRNA-associated Th17 cell responses with neutralizing antibodies against Streptococcus pneumoniae in macaques.

  Y Fukuyama; Y Yuki; Y Katakai; N Harada; H Takahashi; S Takeda; M Mejima; S Joo; S Kurokawa; S Sawada; H Shibata; E J Park; K Fujihashi; D E Briles; Y Yasutomi; H Tsukada; K Akiyoshi; H Kiyono

  Mucosal immunology, Sep. 2015

  
• Long-Lasting and Efficient Tumor Imaging Using a High Relaxivity Polysaccharide Nanogel Magnetic Resonance Imaging Contrast Agent

  Minnie Chan; Jacques Lux; Tomoki Nishimura; Kazunari Akiyoshi; Adah Almutairi

  BIOMACROMOLECULES, Sep. 2015

  
• Nanocarrier-Integrated Microspheres: Nanogel Tectonic Engineering for Advanced Drug-Delivery Systems

  Yoshiro Tahara; Sada-atsu Mukai; Shin-ichi Sawada; Yoshihiro Sasaki; Kazunari Akiyoshi

  ADVANCED MATERIALS, Sep. 2015, Peer-reviewed

  
• Development of a Novel Tetravalent Synthetic Peptide That Binds to Phosphatidic Acid

  Rina Ogawa; Kohjiro Nagao; Kentaro Taniuchi; Masaki Tsuchiya; Utako Kato; Yuji Hara; Takehiko Inaba; Toshihide Kobayashi; Yoshihiro Sasaki; Kazunari Akiyoshi; Miho Watanabe-Takahashi; Kiyotaka Nishikawa; Masato Umeda

  PLOS ONE, Jul. 2015

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• Glyco Star Polymers as Helical Multivalent Host and Biofunctional Nano-Platform

  Tomoki Nishimura; Sada-atsu Mukai; Shin-ichi Sawada; Kazunari Akiyoshi

  ACS MACRO LETTERS, Apr. 2015, Peer-reviewed

  
• Protein nanogelation using vitamin B-6-bearing pullulan: effect of zinc ions

  Yuji Tsuchido; Yoshihiro Sasaki; Shin-ichi Sawada; Kazunari Akiyoshi

  POLYMER JOURNAL, Feb. 2015, Peer-reviewed

  
• A Fluorometric Biochemical Gas Sensor (Biosniffer) for Acetaldehyde Vapor Based on Catalytic Reaction of Aldehyde Dehydrogenase

  Yuki Suzuki; Ming Ye; Kumiko Miyajima; Takahiro Arakawa; Shin-ichi Sawada; Hiroyuki Kudo; Kazunari Akiyoshi; Kohji Mitsubayashi

  SENSORS AND MATERIALS, 2015

  
• Affinity-mediated capture and release of amphiphilic copolymers for controlling antimicrobial activity

  Haruko Takahashi; Kazunari Akiyoshi; Kenichi Kuroda

  CHEMICAL COMMUNICATIONS, 2015

  
• The design of phenylboronic acid azoprobe-polyamidoamine dendrimer complexes as supramolecular sensors for saccharide recognition in water

  Yuji Tsuchido; Yuuki Sakai; Keisuke Aimu; Takeshi Hashimoto; Kazunari Akiyoshi; Takashi Hayashita

  NEW JOURNAL OF CHEMISTRY, 2015, Peer-reviewed

  
• Nanogel-crosslinked nanoparticles increase the inhibitory effects of W9 synthetic peptide on bone loss in a murine bone resorption model

  Toshimi Sato; Neil Alles; Masud Khan; Kenichi Nagano; Mariko Takahashi; Yukihiko Tamura; Asako Shimoda; Keiichi Ohya; Kazunari Akiyoshi; Kazuhiro Aoki

  INTERNATIONAL JOURNAL OF NANOMEDICINE, 2015, Peer-reviewed

  
• Amylose-Based Cationic Star Polymers for siRNA Delivery

  Tomoki Nishimura; Kaori Umezaki; Sada-atsu Mukai; Shin-ichi Sawada; Kazunari Akiyoshi

  BIOMED RESEARCH INTERNATIONAL, 2015, Peer-reviewed

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• Effective CpG DNA delivery using amphiphilic cycloamylose nanogels

  Y. Tahara; J. Yasuoka; S. Sawada; Y. Sasaki; K. Akiyoshi

  BIOMATERIALS SCIENCE, 2015, Peer-reviewed

  
• Nanogel tectonic porous gel loading biologics, nanocarriers, and cells for advanced scaffold

  Yoshihide Hashimoto; Sada-atsu Mukai; Shin-ichi Sawada; Yoshihiro Sasaki; Kazunari Akiyoshi

  BIOMATERIALS, Jan. 2015, Peer-reviewed

  
• Nanogel-crosslinked nanoparticles increase the inhibitory effects of W9 synthetic peptide on bone loss in a murine bone resorption model.

  Sato T; Alles N; Khan M; Nagano K; Takahashi M; Tamura Y; Shimoda A; Ohya K; Akiyoshi K; Aoki K

  International journal of nanomedicine, 2015, Peer-reviewed

  
• Cycloamylose-nanogel drug delivery system-mediated intratumor silencing of the vascular endothelial growth factor regulates neovascularization in tumor microenvironment

  Hidetaka Fujii; Masaharu Shin-Ya; Shigeo Takeda; Yoshihide Hashimoto; Sada-atsu Mukai; Shin-ichi Sawada; Tetsuya Adachi; Kazunari Akiyoshi; Tsuneharu Miki; Osam Mazda

  CANCER SCIENCE, Dec. 2014, Peer-reviewed

  
• Development and Potential Theranostic Applications of a Self-Assembled Hybrid of Magnetic Nanoparticle Clusters with Polysaccharide Nanogels

  Kiyofumi Katagiri; Keiko Ohta; Kaori Sako; Kei Inumaru; Koichiro Hayashi; Yoshihiro Sasaki; Kazunari Akiyoshi

  CHEMPLUSCHEM, Nov. 2014

  
• Nanogel-Based Immunologically Stealth Vaccine Targets Macrophages in the Medulla of Lymph Node and Induces Potent Antitumor Immunity

  Daisuke Muraoka; Naozumi Harada; Tae Hayashi; Yoshiro Tahara; Fumiyasu Momose; Shin-ichi Sawada; Sada-atsu Mukai; Kazunari Akiyoshi; Hiroshi Shiku

  ACS NANO, Sep. 2014, Peer-reviewed

  
• Therapeutic Effect of Nanogel-Based Delivery of Soluble FGFR2 with S252W Mutation on Craniosynostosis

  Masako Yokota; Yukiho Kobayashi; Jumpei Morita; Hiroyuki Suzuki; Yoshihide Hashimoto; Yoshihiro Sasaki; Kazunari Akiyoshi; Keiji Moriyama

  PLOS ONE, Jul. 2014

  
• Nanogel-based PspA nasal vaccine induces microRNA-associated protective immunity in nonhuman primates

  Yoshiko Fukuyama; Yoshikazu Yuki; Yuko Katakai; Haruko Takahashi; Shinichi Sawada; Sunyi Joo; Eun Jeong Park; Kazunari Akiyoshi; Hiroshi Kiyono

  JOURNAL OF IMMUNOLOGY, May 2014

  
• Dual-sugar Nanogel Comprising beta-1,3-Glucan and Cholesterol-bearing Dextran for Protein Delivery Targeting Antigen Presenting Cells

  Yoshiya Maegawa; Shinichi Mochizuki; Yusuke Sanada; Kazunari Akiyoshi; Kazuo Sakurai

  CHEMISTRY LETTERS, May 2014

  
• Microrheology of polysaccharide nanogel-integrated system

  Yurina Sekine; Kimiko Okazaki; Tomoko Ikeda-Fukazawa; Masatoshi Ichikawa; Kenichi Yoshikawa; Sada-atsu Mukai; Kazunari Akiyoshi

  COLLOID AND POLYMER SCIENCE, Feb. 2014, Peer-reviewed

  
• 2P314 Development of hybrid exosomes by liposome fusion(28. Bioengineering,Poster,The 52nd Annual Meeting of the Biophysical Society of Japan(BSJ2014))

  Sato Yuko; Umezaki Kaori; Sawada Shin-ichi; Mukai Sada-atsu; Akiyoshi Kazunari

  Seibutsu Butsuri, 2014

  
• ナノゲル―リポソームハイブリッドゲルの設計とバイオ応用

  佐々木 善浩; 澤田 晋一; 秋吉 一成

  日本化学繊維研究所講演集 Annual report of the Research Institute for Chemical Fibers, Japan, Jan. 2014

  
• Proteo-liposome Engineering: Chaperoning Science for Preparation of Membrane Protein-reconstituted Liposomes

  安藤満; 安藤満; 吉田昭介; 吉田昭介; 澤田晋一; 澤田晋一; 秋吉一成; 秋吉一成

  膜, 2014

  
• 細胞外ベクシルの構造特性と機能制御 (特集 エクソソームとDDS)

  下田 麻子; 澤田 晋一; 秋吉 一成

  Drug delivery system : DDS : official journal of the Japan Society of Drug Delivery System, Jan. 2014

  
• The Effect of Hydrophilic Ionic Liquids 1-Ethyl-3-Methylimidazolium Lactate and Choline Lactate on Lipid Vesicle Fusion

  Eri H. Hayakawa; Eiko Mochizuki; Tetsuya Tsuda; Kazunari Akiyoshi; Hiroyuki Matsuoka; Susumu Kuwabata

  PLOS ONE, Dec. 2013

  
• Hepatic Crown-Like Structure: A Unique Histological Feature in Non-Alcoholic Steatohepatitis in Mice and Humans

  Michiko Itoh; Hideaki Kato; Takayoshi Suganami; Kuniha Konuma; Yoshio Marumoto; Shuji Terai; Hiroshi Sakugawa; Sayaka Kanai; Miho Hamaguchi; Takahiro Fukaishi; Seiichiro Aoe; Kazunari Akiyoshi; Yoshihiro Komohara; Motohiro Takeya; Isao Sakaida; Yoshihiro Ogawa

  PLOS ONE, Dec. 2013

  
• Molecular logistics using cytocleavable polyrotaxanes for the reactivation of enzymes delivered in living cells

  Atsushi Tamura; Go Ikeda; Ji-Hun Seo; Koji Tsuchiya; Hirofumi Yajima; Yoshihiro Sasaki; Kazunari Akiyoshi; Nobuhiko Yui

  SCIENTIFIC REPORTS, Jul. 2013

  
• Nanogel bottom-up gel biomaterials for protein delivery: Photopolymerization of an acryloyl-modified polysaccharide nanogel macromonomer

  Yoshiro Tahara; Satoshi Kosuge; Shin-ichi Sawada; Yoshihiro Sasaki; Kazunari Akiyoshi

  REACTIVE & FUNCTIONAL POLYMERS, Jul. 2013, Peer-reviewed

  
• Templated nucleation of hybrid iron oxide nanoparticles on polysaccharide nanogels

  Kiyofumi Katagiri; Keiko Ohta; Kunihito Koumoto; Kei Kurosu; Yoshihiro Sasaki; Kazunari Akiyoshi

  COLLOID AND POLYMER SCIENCE, Jun. 2013

  
• Polysaccharide-Hair Cationic Polypeptide Nanogels: Self-Assembly and Enzymatic Polymerization of Amylose Primer-Modified Cholesteryl Poly(L-lysine)

  Nobuyuki Morimoto; Mio Yamazaki; Junko Tamada; Kazunari Akiyoshi

  LANGMUIR, Jun. 2013

  
• Nanogel-Based PspA Intranasal Vaccine Prevents Invasive Disease and Nasal Colonization by Streptococcus pneumoniae

  Il Gyu Kong; Ayuko Sato; Yoshikazu Yuki; Tomonori Nochi; Haruko Takahashi; Shinichi Sawada; Mio Mejima; Shiho Kurokawa; Kazunari Okada; Shintaro Sato; David E. Briles; Jun Kunisawa; Yusuke Inoue; Masafumi Yamamoto; Kazunari Akiyoshi; Hiroshi Kiyono

  INFECTION AND IMMUNITY, May 2013, Peer-reviewed

  
• Sphingosine Kinase 2 inhibitor SG-12 induces apoptosis via phosphorylation by sphingosine Kinase 2

  Miki Hara-Yokoyama; Kazue Terasawa; Shizuko Ichinose; Akihiko Watanabe; Katarzyna A. Podyma-Inoue; Kazunari Akiyoshi; Yasuyuki Igarashi; Masaki Yanagishita

  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Apr. 2013

  
• シャペロン機能工学による新規バイオ材料の創製

  澤田 晋一; 秋吉 一成

  化学と工業 = Chemistry and chemical industry, 01 Feb. 2013

  
• Self-Assembled pH-Sensitive Cholesteryl Pullulan Nanogel As a Protein Delivery Vehicle

  Nobuyuki Morimoto; Sayaka Hirano; Haruko Takahashi; Scott Loethen; David H. Thompson; Kazunari Akiyoshi

  BIOMACROMOLECULES, Jan. 2013

  
• Control of in vivo spatiotemporal dynamics of antigen and adjuvant by a delivery system CHP nanogel markedly improves the immunogenicity and antitumor efficacy of long peptide cancer vaccine.

  Daisuke Muraoka; Naozumi Harada; Tae Hayashi; Shin-ichi Sawada; Kazunari Akiyoshi; Hiroshi Shiku

  CANCER RESEARCH, Jan. 2013

  
• 多糖ナノボールの機能化とバイオ応用 (特別記念号)

  秋吉 一成; 澤田 晋一

  日本化学繊維研究所講演集 Annual report of the Research Institute for Chemical Fibers, Japan, Jan. 2013

  
• A polyion complex nanogel

  Masafumi Takeo; Takeshi Mori; Takuro Niidome; Shinichi Sawada; Kazunari Akiyoshi; Yoshiki Katayama

  JOURNAL OF COLLOID AND INTERFACE SCIENCE, Jan. 2013, Peer-reviewed

  
• 29aPS-22 Design and structural properties of polysaccharide nanogel cross-linked gels

  Mukai S.; Hashimoto Y.; Tahara Y.; Sawada S.; Akiyoshi K.

  Meeting abstracts of the Physical Society of Japan, Jan. 2013

  
• Structure and mechanical properties of nanogel-crosslinked gels

  Mukai S.; Hashimoto Y.; Tahara Y.; Sawada S.; Akiyoshi K.

  Meeting abstracts of the Physical Society of Japan, Jan. 2013

  
• Nanogel-based antigen-delivery system for nasal vaccines

  Yoshikazu Yuki; Tomonori Nochi; Il Gyu Kong; Haruko Takahashi; Shin-ichi Sawada; Kazunari Akiyoshi; Hiroshi Kiyono

  BIOTECHNOLOGY AND GENETIC ENGINEERING REVIEWS, VOL 29, ISSUE1, 2013, Peer-reviewed

  
• Amphiphilic nanogel of enzymatically synthesized glycogen as an artificial molecular chaperone for effective protein refolding

  Shigeo Takeda; Haruko Takahashi; Shin-ichi Sawada; Yoshihiro Sasaki; Kazunari Akiyoshi

  RSC ADVANCES, 2013, Peer-reviewed

  
• Cyclodextrin triggered dimensional changes of polysaccharide nanogel integrated hydrogels at nanometer resolution

  Ming Gao; Sayaka Toita; Shin-ichi Sawada; Kazunari Akiyoshi; Bjorn Torger Stokke

  SOFT MATTER, 2013, Peer-reviewed

  
• Cationic amphiphilic polysaccharide nanoballs: protein stabilization and intracellular delivery by nano-encapsulation

  Haruko Takahashi; Yoshiro Tahara; Shin-ichi Sawada; Kazunari Akiyoshi

  BIOMATERIALS SCIENCE, 2013, Peer-reviewed

  
• A Hybrid Hydrogel Biomaterial by Nanogel Engineering: Bottom-Up Design with Nanogel and Liposome Building Blocks to Develop a Multidrug Delivery System

  Yurina Sekine; Yuki Moritani; Tomoko Ikeda-Fukazawa; Yoshihiro Sasaki; Kazunari Akiyoshi

  ADVANCED HEALTHCARE MATERIALS, Nov. 2012, Peer-reviewed

  
• Dual crosslinked hydrogel nanoparticles by nanogel bottom-up method for sustained-release delivery

  Asako Shimoda; Shin-ichi Sawada; Arihiro Kano; Atsushi Maruyama; Alexandre Moquin; Francoise M. Winnik; Kazunari Akiyoshi

  COLLOIDS AND SURFACES B-BIOINTERFACES, Nov. 2012, Peer-reviewed

  
• Cholesteryl group- and acryloyl group-bearing pullulan nanogel to deliver BMP2 and FGF18 for bone tissue engineering

  Masako Fujioka-Kobayashi; Masato S. Ota; Asako Shimoda; Ken-ichi Nakahama; Kazunari Akiyoshi; Youji Miyamoto; Sachiko Iseki

  BIOMATERIALS, Oct. 2012

  
• Exploitation of a novel polysaccharide nanogel cross-linking membrane for guided bone regeneration (GBR)

  Takayuki Miyahara; Myat Nyan; Asako Shimoda; Yuka Yamamoto; Shinji Kuroda; Makoto Shiota; Kazunari Akiyoshi; Shohei Kasugai

  JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Aug. 2012

  
• Templated Formation of Hydroxyapatite Nanoparticles from Self-Assembled Nanogels Containing Tricarboxylate Groups

  Yoshihiro Sasaki; Setsuko Yamane; Kei Kurosu; Shin-Ichi Sawada; Kazunari Akiyoshi

  POLYMERS, Jun. 2012, Peer-reviewed

  
• Adjuvant-free nanogel-based PspA nasal vaccine for the induction of protective immunity against Pneumococcus

  Yoshikazu Yuki; Il Kong; Ayuko Sato; Tomonori Nochi; Mio Mejima; Shiho Kurokawa; Tomoko Hiroiwa; Yoshiko Fukuyama; Shinichi Sawada; Haruko Takahashi; Kazunari Akiyoshi; Hiroshi Kiyono

  JOURNAL OF IMMUNOLOGY, May 2012

  
• Apoptotic marginal zone deletion of anti-Sm/ribonucleoprotein B cells

  Yusuke Kishi; Tetsuya Higuchi; Shirly Phoon; Yasuo Sakamaki; Koki Kamiya; Gabriela Riemekasten; Kazunari Akiyoshi; Martin G. Weigert; Takeshi Tsubata

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, May 2012, Peer-reviewed

  
• Injectable Hydrogel for Sustained Protein Release by Salt-Induced Association of Hyaluronic Acid Nanogel

  Takashi Nakai; Tai Hirakura; Yuji Sakurai; Tsuyoshi Shimoboji; Masaki Ishigai; Kazunari Akiyoshi

  MACROMOLECULAR BIOSCIENCE, Apr. 2012, Peer-reviewed

  
• Synthesis and Biological Properties of Highly Sequence-Specific-Alkylating N-Methylpyrrole-N-Methylimidazole Polyamide Conjugates

  Gengo Kashiwazaki; Toshikazu Bando; Tomofumi Yoshidome; Seiji Masui; Toshiki Takagaki; Kaori Hashiya; Ganesh N. Pandian; Junichi Yasuoka; Kazunari Akiyoshi; Hiroshi Sugiyama

  JOURNAL OF MEDICINAL CHEMISTRY, Mar. 2012, Peer-reviewed

  
• Self-assembled Nanogel Engineering for Advanced Biomedical Technology

  Yoshihiro Sasaki; Kazunari Akiyoshi

  CHEMISTRY LETTERS, Mar. 2012, Peer-reviewed

  
• Biodegradable nanogel-integrated hydrogels for sustained protein delivery

  Asako Shimoda; Yuka Yamamoto; Shin-ichi Sawada; Kazunari Akiyoshi

  MACROMOLECULAR RESEARCH, Mar. 2012, Peer-reviewed

  
• 3PT125 Liposomes as chaperone in cell-free membrane protein synthesis(The 50th Annual Meeting of the Biophysical Society of Japan)

  Akiyama Minato; Yasuoka Jun-ichi; Sawada Shin-ichi; Akiyoshi Kazunari

  Seibutsu Butsuri, 2012

  
• Shear flow-induced nanotubulation of surface-immobilized liposomes

  Yurina Sekine; Keita Abe; Akitaka Shimizu; Yoshihiro Sasaki; Shin-ichi Sawada; Kazunari Akiyoshi

  RSC ADVANCES, 2012, Peer-reviewed

  
• Artificial chaperone polysaccharide nanogels for protein delivery: a thermodynamic study of protein-nanogel interactions using fluorescence correlation spectroscopy.

  Yoshihiro Sasaki; Daisuke Iida; Haruko Takahashi; Shin-ichi Sawada; Kazunari Akiyoshi

  Current drug discovery technologies, 01 Dec. 2011

  
• Cadherin-integrated liposomes with potential application in a drug delivery system

  Koki Kamiya; Kanta Tsumoto; Tetsuro Yoshimura; Kazunari Akiyoshi

  BIOMATERIALS, Dec. 2011, Peer-reviewed

  
• The tumor necrosis factor type 2 receptor plays a protective role in tumor necrosis factor-α-induced bone resorption lacunae on mouse calvariae.

  Kenichi Nagano; Neil Alles; Anower; Hussain Mian; Asako Shimoda; Nobuyuki Morimoto; Yukihiko Tamura; Hitoyata Shimokawa; Kazunari Akiyoshi; Keiichi Ohya; Kazuhiro Aoki

  J. Bone Miner. Metab., Nov. 2011, Peer-reviewed

  
• The tumor necrosis factor type 2 receptor plays a protective role in tumor necrosis factor-alpha-induced bone resorption lacunae on mouse calvariae

  Kenichi Nagano; Neil Alles; Anower Hussain Mian; Asako Shimoda; Nobuyuki Morimoto; Yukihiko Tamura; Hitoyata Shimokawa; Kazunari Akiyoshi; Keiichi Ohya; Kazuhiro Aoki

  JOURNAL OF BONE AND MINERAL METABOLISM, Nov. 2011, Peer-reviewed

  
• Synthesis and in situ insertion of a site-specific fluorescently labeled membrane protein into cell-sized liposomes

  Takuma Ohtsuka; Satoshi Neki; Tamotsu Kanai; Kazunari Akiyoshi; Shin-ichiro M. Nomura; Takashi Ohtsuki

  ANALYTICAL BIOCHEMISTRY, Nov. 2011, Peer-reviewed

  
• Polysaccharide nanogel gene delivery system with endosome-escaping function: Co-delivery of plasmid DNA and phospholipase A(2)

  Sayaka Toita; Shin-ichi Sawada; Kazunari Akiyoshi

  JOURNAL OF CONTROLLED RELEASE, Oct. 2011, Peer-reviewed

  
• The use of cationic nanogels to deliver proteins to myeloma cells and primary T lymphocytes that poorly express heparan sulfate

  Kozo Watanabe; Yumiko Tsuchiya; Yoshinori Kawaguchi; Shin-ichi Sawada; Hirohito Ayame; Kazunari Akiyoshi; Takeshi Tsubata

  BIOMATERIALS, Sep. 2011

  
• Biomedical soft contact-lens sensor for in situ ocular biomonitoring of tear contents

  MingXing Chu; Takayuki Shirai; Daishi Takahashi; Takahiro Arakawa; Hiroyuki Kudo; Kenji Sano; Shin-ichi Sawada; Kazuyoshi Yano; Yasuhiko Iwasaki; Kazunari Akiyoshi; Manabu Mochizuki; Kohji Mitsubayashi

  BIOMEDICAL MICRODEVICES, Aug. 2011

  
• Cell Specific Peptide-Conjugated Polysaccharide Nanogels for Protein Delivery

  Asako Shimoda; Shin-ichi Sawada; Kazunari Akiyoshi

  MACROMOLECULAR BIOSCIENCE, Jul. 2011, Peer-reviewed

  
• Nanogel Engineering for Development of New Drug Delivery System

  SAWADA Shin-ichi; AKIYOSHI Kazunari

  MEMBRANE, Jul. 2011

  
• Amphiphilic Polysaccharide Nanogels as Artificial Chaperones in Cell-Free Protein Synthesis

  Yoshihiro Sasaki; Wakiko Asayama; Tatsuya Niwa; Shin-ichi Sawada; Takuya Ueda; Hideki Taguchi; Kazunari Akiyoshi

  MACROMOLECULAR BIOSCIENCE, Jun. 2011, Peer-reviewed

  
• 多様に構造変化する,0次元の物質 両親媒性分子の自己組織化 (特集 自己組織化の物理学)

  秋吉 一成

  パリティ,26 (5), pp. 22-24, May 2011

  
• Nanogel-Based Scaffold Delivery of Prostaglandin E-2 Receptor-Specific Agonist in Combination With a Low Dose of Growth Factor Heals Critical-Size Bone Defects in Mice

  Paksinee Kamolratanakul; Tadayoshi Hayata; Yoichi Ezura; Aya Kawamata; Chikako Hayashi; Yuka Yamamoto; Hiroaki Hemmi; Masashi Nagao; Ryo Hanyu; Takuya Notomi; Tetsuya Nakamoto; Teruo Amagasa; Kazunari Akiyoshi; Masaki Noda

  ARTHRITIS AND RHEUMATISM, Apr. 2011

  
• ナノゲルタンパク質デリバリーを用いた経鼻ワクチンの開発

  幸 義和; 清野 宏; 澤田 晋一; 秋吉 一成

  バイオマテリアル : 生体材料 : journal of Japanese Society for Biomaterials,29 (2), pp. 80-87, Apr. 2011

  
• Cyclodextrin-responsive nanogel as an artificial chaperone for horseradish peroxidase

  Shin-ichi Sawada; Yoshihiro Sasaki; Yuta Nomura; Kazunari Akiyoshi

  COLLOID AND POLYMER SCIENCE, Apr. 2011, Peer-reviewed

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• Metal Coordinative-crosslinked Polysaccharide Nanogels with Redox Sensitivity

  Yoshihiro Sasaki; Tai Hirakura; Shin-ichi Sawada; Kazunari Akiyoshi

  CHEMISTRY LETTERS, Feb. 2011, Peer-reviewed

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• Soft contact lens biosensor for in situ monitoring of tear glucose as non-invasive blood sugar assessment

  Ming Xing Chu; Kumiko Miyajima; Daishi Takahashi; Takahiro Arakawa; Kenji Sano; Shin-ichi Sawada; Hiroyuki Kudo; Yasuhiko Iwasaki; Kazunari Akiyoshi; Manabu Mochizuki; Kohji Mitsubayashi

  TALANTA, Jan. 2011

  
• 交互添加による多糖—リン酸カルシウムナノ粒子の作製

  山根 説子; 菅原 彩絵; 秋吉 一成

  沼津工業高等専門学校研究報告,45, pp. 345-350, Jan. 2011

  
• Construction of protein-crosslinked nanogels with vitamin B-6 bearing polysaccharide

  Yoshihiro Sasaki; Yuji Tsuchido; Shin-ichi Sawada; Kazunari Akiyoshi

  POLYMER CHEMISTRY, 2011, Peer-reviewed

  
• Amphiphilic Polysaccharide Nanoballs: A New Building Block for Nanogel Biomedical Engineering and Artificial Chaperones

  Haruko Takahashi; Shin-ichi Sawada; Kazunari Akiyoshi

  ACS NANO, Jan. 2011, Peer-reviewed

  
• ナノゲルを基盤材料とするナノバイオエンジニアリング

  佐々木 善浩; 秋吉 一成

  人工臓器, 15 Dec. 2010

  
• POLYSACCHARIDE NANOGEL ENGINEERING FOR DDS

  Kazunari Akiyoshi

  JOURNAL OF GENE MEDICINE, Dec. 2010

  
• Nanogel Engineering for New Nanobiomaterials: From Chaperoning Engineering to Biomedical Applications

  Yoshihiro Sasaki; Kazunari Akiyoshi

  CHEMICAL RECORD, Dec. 2010

  
• Preparation of Connexin43-Integrated Giant Liposomes by a Baculovirus Expression Liposome Fusion Method

  Koki Kamiya; Kanta Tsumoto; Satoko Arakawa; Shigeomi Shimizu; Ikuo Morita; Tetsuro Yoshimura; Kazunari Akiyoshi

  BIOTECHNOLOGY AND BIOENGINEERING, Dec. 2010, Peer-reviewed

  
• Molecular Communication between Liposomes and Cells

  NOMURA Shin-ichiro; MORITANI Yuki; AKIYOSHI Kazunari

  JRSJ, Dec. 2010

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• Suppression of NF-kappa B Increases Bone Formation and Ameliorates Osteopenia in Ovariectomized Mice

  Neil Alles; Niroshani S. Soysa; Juri Hayashi; Masud Khan; Asako Shimoda; Hitoyata Shimokawa; Olaf Ritzeler; Kazunari Akiyoshi; Kazuhiro Aoki; Keiichi Ohya

  ENDOCRINOLOGY, Oct. 2010

  
• Polysaccharide nanogel-cyclodextrin system as an artificial chaperone for in vitro protein synthesis of green fluorescent protein

  Yoshihiro Sasaki; Yuta Nomura; Shin-ichi Sawada; Kazunari Akiyoshi

  POLYMER JOURNAL, Oct. 2010, Peer-reviewed

  
• Suppression of NF-kappaB increases bone formation and ameliorates osteopenia in ovariectomized mice.

  Alles Neil; Soysa Niroshani S; Hayashi Juri; Khan Masud; Shimoda Asako; Shimokawa Hitoyata; Ritzeler Olaf; Akiyoshi Kazunari; Aoki Kazuhiro; Ohya Keiichi

  Endocrinology, Oct. 2010

  
• DNA separation by cholesterol-bearing pullulan nanogels

  Keisuke Kondo; Noritada Kaji; Sayaka Toita; Yukihiro Okamoto; Manabu Tokeshi; Kazunari Akiyoshi; Yoshinobu Baba

  BIOMICROFLUIDICS, Sep. 2010

  
• Direct integration of cell-free-synthesized connexin-43 into liposomes and hemichannel formation

  Yuki Moritani; Shin-ichiro M. Nomura; Ikuo Morita; Kazunari Akiyoshi

  FEBS JOURNAL, Aug. 2010

  
• Nanogel antigenic protein-delivery system for adjuvant-free intranasal vaccines (vol 9, pg 572, 2010)

  Tomonori Nochi; Yoshikazu Yuki; Haruko Takahashi; Shin-ichi Sawada; Mio Mejima; Tomoko Kohda; Norihiro Harada; Il Gyu Kong; Ayuko Sato; Nobuhiro Kataoka; Daisuke Tokuhara; Shiho Kurokawa; Yuko Takahashi; Hideo Tsukada; Shunji Kozaki; Kazunari Akiyoshi; Hiroshi Kiyono

  NATURE MATERIALS, Aug. 2010

  
• Design of hybrid hydrogels with nanogel and liposomes as cross-linking domains

  Yurina Sekine; Yuki Moritani; Nobuyuki Morimoto; Kazunari Akiyoshi

  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2010

  
• Nanogel antigenic protein-delivery system for adjuvant-free intranasal vaccines

  Tomonori Nochi; Yoshikazu Yuki; Haruko Takahashi; Shin-ichi Sawada; Mio Mejima; Tomoko Kohda; Norihiro Harada; Il Gyu Kong; Ayuko Sato; Nobuhiro Kataoka; Daisuke Tokuhara; Shiho Kurokawa; Yuko Takahashi; Hideo Tsukada; Shunji Kozaki; Kazunari Akiyoshi; Hiroshi Kiyono

  NATURE MATERIALS, Jul. 2010

  
• Nanogel antigen delivery system for adjuvant-free intranasal vaccines

  Tomonori Nochi; Yoshikazu Yuki; Haruko Takahashi; Shinichi Sawada; Mio Mejima; Tomoko Kohda; Norihiro Harada; Nobuhiro Kataoka; Il Gyu Kong; Ayuko Sato; Daisuke Tokuhara; Shiho Kurokawa; Yuko Takahashi; Hideo Tsukada; Shunji Kozaki; Kazunari Akiyoshi; Hiroshi Kiyono

  JOURNAL OF IMMUNOLOGY, Apr. 2010

  
• Development of an Artificial Chaperone System Based on Cyclodextrin

  Yoshihiro Sasaki; Kazunari Akiyoshi

  CURRENT PHARMACEUTICAL BIOTECHNOLOGY, Apr. 2010

  
• Nano-Encapsulation of Lipase by Self-Assembled Nanogels: Induction of High Enzyme Activity and Thermal Stabilization

  Shin-ichi Sawada; Kazunari Akiyoshi

  MACROMOLECULAR BIOSCIENCE, Apr. 2010, Peer-reviewed

  
• Hybrid hyaluronan hydrogel encapsulating nanogel as a protein nanocarrier: New system for sustained delivery of protein with a chaperone-like function

  Tai Hirakura; Kenji Yasugi; Takayuki Nemoto; Mika Sato; Tsuyoshi Shimoboji; Yoshinori Aso; Nobuyuki Morimoto; Kazunari Akiyoshi

  JOURNAL OF CONTROLLED RELEASE, Mar. 2010

  
• Functional Cycloamylose as a Polysaccharide-Based Biomaterial: Application in a Gene Delivery System

  Sayaka Toita; Nobuyuki Morimoto; Kazunari Akiyoshi

  BIOMACROMOLECULES, Feb. 2010

  
• The effects of anti-bone resorptive peptide with nanogel sheet as a peptide carrier: comparison to a nanogel cross-linking hydrogel

  Kazuhiro Aoki; Neil Alles; Masud Kahn; Asako Shimoda; Kenichi Nagano; Kazunari Akiyoshi; Keiichi Ohya

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010

  
• P-102 Mutagenicity and anti-cancer activity of DNA ADP-ribosylating protein, pierisin-1(Poster Presentation)

  Koshida Hideshi; Yamamoto Masafumi; Totsuka Yukari; Nakano Tsuyoshi; Hibiya Yuko; Nakaguchi Azusa; Ohta Toshihiro; Akiyoshi Kazunari; Sugimura Takashi; Wakabayashi Keiji

  日本環境変異原学会大会プログラム・要旨集, 2010

  
• ナノゲルエンジニアリングによるタンパク質DDSの開発

  秋吉 一成; 佐々木 善浩; 澤田 晋一

  生体材料工学研究所年報,44, pp. 24-28, Jan. 2010

  
• ナノゲル工学による新規DDSの設計

  澤田 晋一; 秋吉 一成

  薬剤学 = The archives of practical pharmacy,70 (1), pp. 39-44, Jan. 2010

  
• Raspberry-like assembly of cross-linked nanogels for protein delivery

  Urara Hasegawa; Shin-ichi Sawada; Takeshi Shimizu; Tsunao Kishida; Eigo Otsuji; Osam Mazda; Kazunari Akiyoshi

  JOURNAL OF CONTROLLED RELEASE, Dec. 2009

  
• Protein Synthesis in Giant Liposomes Using the In Vitro Translation System of Thermococcus kodakaraensis

  Kazuaki Yamaji; Tamotsu Kanai; Shin-Ichiro M. Nomura; Kazunari Akiyoshi; Makiko Negishi; Yong Chen; Haruyuki Atomi; Kenichi Yoshikawa; Tadayuki Imanaka

  IEEE TRANSACTIONS ON NANOBIOSCIENCE, Dec. 2009

  
• Cycloamylose-based Biomaterial: Nanogel of Cholesterol-bearing Cationic Cycloamylose for siRNA Delivery

  Sayaka Toita; Yuki Soma; Nobuyuki Morimoto; Kazunari Akiyoshi

  CHEMISTRY LETTERS, Nov. 2009

  
• The binding of pullulan modified cholesteryl nanogels to A beta oligomers and their suppression of cytotoxicity

  Sebastien Boridy; Haruko Takahashi; Kazunari Akiyoshi; Dusica Maysinger

  BIOMATERIALS, Oct. 2009

  
• Effects of Cholesterol-Bearing Pullulan (CHP)-Nanogels in Combination with Prostaglandin E1 on Wound Healing

  Hiroshi Kobayashi; Osamu Katakura; Nobuyuki Morimoto; Kazunari Akiyoshi; Shohei Kasugai

  JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, Oct. 2009

  
• A soft and flexible biosensor using a phospholipid polymer for continuous glucose monitoring

  MingXing Chu; Hiroyuki Kudo; Takayuki Shirai; Kumiko Miyajima; Hirokazu Saito; Nobuyuki Morimoto; Kazuyoshi Yano; Yasuhiko Iwasaki; Kazunari Akiyoshi; Kohji Mitsubayashi

  BIOMEDICAL MICRODEVICES, Aug. 2009

  
• Direct formation of proteo-liposomes by in vitro synthesis and cellular cytosolic delivery with connexin-expressing liposomes

  Makoto Kaneda; Shin-ichiro M. Nomura; Shizuko Ichinose; Satoshi Kondo; Ken-ichi Nakahama; Kazunari Akiyoshi; Ikuo Morita

  BIOMATERIALS, Aug. 2009

  
• Osteoblastic Bone Formation Is Induced by Using Nanogel-Crosslinking Hydrogel as Novel Scaffold for Bone Growth Factor

  Chikako Hayashi; Urara Hasegawa; Yoshitomo Saita; Hiroaki Hemmi; Tadayoshi Hayata; Kazuhisa Nakashima; Yoichi Ezura; Teruo Amagasa; Kazunari Akiyoshi; Masaki Noda

  JOURNAL OF CELLULAR PHYSIOLOGY, Jul. 2009

  
• Self-Assembled Nanogel of Hydrophobized Dendritic Dextrin for Protein Delivery

  Yayoi Ozawa; Shin-ichi Sawada; Nobuyuki Morimoto; Kazunari Akiyoshi

  MACROMOLECULAR BIOSCIENCE, Jul. 2009

  
• Polysaccharide nanogel delivery of a TNF-alpha and RANKL antagonist peptide allows systemic prevention of bone loss

  Neil Alles; Niroshani S. Soysa; M. D. Anower Hussain; Nobuyoshi Tomomatsu; Hiroaki Saito; Roland Baron; Nobuyuki Morimoto; Kazuhiro Aoki; Kazunari Akiyoshi; Keiichi Ohya

  EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, May 2009

  
• Interaction of Self-assembled Cationic Nanogels with Oligo-DNA and Function as Artificial Nucleic Acid Chaperone

  Nobuyuki Morimoto; Junko Tamada; Shin-ichi Sawada; Naohiko Shimada; Arihiro Kano; Atsushi Maruyama; Kazunari Akiyoshi

  CHEMISTRY LETTERS, May 2009

  
• Polysaccharide nanogel delivery of a TNF-alpha and RANKL antagonist peptide allows systemic prevention of bone loss.

  Alles Neil; Soysa Niroshani S; Hussain M D Anower; Tomomatsu Nobuyoshi; Saito Hiroaki; Baron Roland; Morimoto Nobuyuki; Aoki Kazuhiro; Akiyoshi Kazunari; Ohya Keiichi

  Eur J Pharm Sci, May 2009

  
• ANA Deficiency Enhances Bone Morphogenetic Protein-induced Ectopic Bone Formation via Transcriptional Events

  Kentaro Miyai; Mitsuhiro Yoneda; Urara Hasegawa; Sayaka Toita; Yayoi Izu; Hiroaki Hemmi; Tadayoshi Hayata; Yoichi Ezura; Shuki Mizutani; Kohei Miyazono; Kazunari Akiyoshi; Tadashi Yamamoto; Masaki Nodaa

  JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 2009

  
• A novel nanosize protein-carrier for the development of adjuvant-free nasal vaccine

  Yoshikazu Yuki; Tomonori Nochi; Mio Mejima; Nobuhiro Kataoka; Haruko Takahashi; Shinichi Sawada; Tomoko Kohda; Shunji Kazaki; Kazunari Akiyoshi; Hiroshi Kiyono

  JOURNAL OF IMMUNOLOGY, Apr. 2009

  
• Enzyme-responsive artificial chaperone system with amphiphilic amylose primer

  Nobuyuki Morimoto; Naruhito Ogino; Tadashi Narita; Kazunari Akiyoshi

  JOURNAL OF BIOTECHNOLOGY, Mar. 2009

  
• Hybrid Nanoapatite by Polysaccharide Nanogel-templated Mineralization

  Setsuko Yamane; Ayae Sugawara; Akihiko Watanabe; Kazunari Akiyoshi

  JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS, Mar. 2009

  
• Nanogel-Calcium Phosphate Hybrid Nanoparticles with Negative or Positive Charges for Potential Biomedical Applications

  Setsuko Yamane; Ayae Sugawara; Yoshihiro Sasaki; Kazunari Akiyoshi

  BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, Mar. 2009

  
• Interaction of nanogel with cyclodextrin or protein: Study by dynamic light scattering and small-angle neutron scattering

  Norihiro Inomoto; Noboru Osaka; Takuya Suzuki; Urara Hasegawa; Yayoi Ozawa; Hitoshi Endo; Kazunari Akiyoshi; Mitsuhiro Shibayama

  POLYMER, Jan. 2009

  
• Composite nanomaterials by self-assembly and controlled crystallization of poly(2-isopropyl-2-oxazoline)-grafted polysaccharides

  Nobuyuki Morimoto; Rodolphe Obeid; Setsuko Yamane; Francoise M. Winnik; Kazunari Akiyoshi

  SOFT MATTER, 2009

  
• The control release of TNF-alpha is necessary to mimic the LPS-induced bone resorption on calvaria

  Kenichi Nagano; Kazuhiro Aoki; Hussain Mian; Neil Alles; Asako Shimoda; Nobuyuki Morimoto; Kazunari Akiyoshi; Keiichi Ohya

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009

  
• Fluorogenically Active Leucine Zipper Peptides as Tag-Probe Pairs for Protein Imaging in Living Cells

  Hiroshi Tsutsumi; Wataru Nomura; Seiichiro Abe; Tomoaki Mino; Akemi Masuda; Nami Ohashi; Tomohiro Tanaka; Kenji Ohba; Naoki Yamamoto; Kazunari Akiyoshi; Hirokazu Tamamura

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009

  
• Siloxane-crosslinked Polysaccharide Nanogels for Potential Biomedical Applications

  Setsuko Yamane; Yoshihiro Sasaki; Kazunari Akiyoshi

  CHEMISTRY LETTERS, Dec. 2008

  
• Interfacing biomembrane mimetic polymer surfaces with living cells - Surface modification for reliable bioartificial liver

  Yasuhiko Iwasaki; Utae Takami; Shin-Ichi Sawada; Kazunari Akiyoshi

  APPLIED SURFACE SCIENCE, Nov. 2008

  
• Dual stimuli-responsive nanogels by self-assembly of polysaccharides lightly grafted with thiol-terminated poly(N-isopropylacrylamide) chains

  Nobuyuki Morinloto; Xing-Ping Qiu; Francoise M. Winnik; Kazunari Akiyoshi

  MACROMOLECULES, Aug. 2008

  
• Glucose sensor using a phospholipid polymer-based enzyme immobilization method

  Hiroyuki Kudo; Tamon Yagi; Ming Xing Chu; Hirokazu Saito; Nobuyuki Morimoto; Yasuhiko Iwasaki; Kazunari Akiyoshi; Kohji Mitsubayashi

  ANALYTICAL AND BIOANALYTICAL CHEMISTRY, Jun. 2008

  
• Self-Assembly of Associated Polymers

  SUGAWARA Ayae; AKIYOSHI Kazunari

  The Pigments,Paints and Printing Inks, 20 May 2008

  
• Protein-conjugated quantum dots effectively delivered into living cells by a cationic nanogel

  Sayaka Toita; Urara Hasegawa; Hideyuki Koga; Ichiro Sekiya; Takeshi Muneta; Kazunari Akiyoshi

  JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, May 2008

  
• Comparison of refolding activities between nanogel artificial chaperone and GroEL systems

  Wakiko Asayama; Shin-Ichi Sawada; Hideki Taguchi; Kazunari Akiyoshi

  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, Apr. 2008

  
• Self-assembled cationic nanogels for intracellular protein delivery

  Hirohito Ayame; Nobuyuki Morimoto; Kazunari Akiyoshi

  BIOCONJUGATE CHEMISTRY, Apr. 2008

  
• Covalent immobilization of antibody fragments on well-defined polymer brushes via site-directed method

  Ryoko Iwata; Rina Satoh; Yasuhiko Iwasaki; Kazunari Akiyoshi

  COLLOIDS AND SURFACES B-BIOINTERFACES, Apr. 2008

  
• Thermo-responsive hydrogels with nanodomains: Rapid shrinking of a nanogel-crosslinking hydrogel of poly(N-isopropyl acrylamide)

  Nobuyuki Morimoto; Takafumi Ohki; Kimio Kurita; Kazunari Akiyoshi

  MACROMOLECULAR RAPID COMMUNICATIONS, Apr. 2008

  
• Humoral immune responses in patients vaccinated with 1-146 HER2 protein complexed with cholesteryl pullulan nanogel

  Shinichi Kageyama; Shigehisa Kitano; Michiko Hirayama; Yasuhiro Nagata; Hiroshi Imai; Taizo Shiraishi; Kazunari Akiyoshi; Andrew M. Scott; Roger Murphy; Eric W. Hoffman; Lloyd J. Old; Naoyuki Katayama; Hiroshi Shiku

  CANCER SCIENCE, Mar. 2008

  
• Nanogel DDS enables sustained release of IL-12 for tumor immunotherapy

  Takeshi Shimizu; Tsunao Kishida; Urara Hasegawa; Yuji Ueda; Jiro Imanishi; Hisakazu Yamagishi; Kazunari Akiyoshi; Eigo Otsuji; Osam Mazda

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Mar. 2008

  
• Exploit of nanogel as a novel carrier of mucosal vaccine: Nanogel mucosal vaccine effectively induces protective immunity against botulinum toxin

  Tomonori Nochi; Yoshikazu Yuki; Mio Mejima; Nobuhiro Kataoka; Kazunari Akiyoshi; Hiroshi Kiyono

  VACCINE, 2008

  
• Direct preparation of giant proteo-liposomes by in vitro membrane protein synthesis

  Shin-ichiro M. Nomura; Satoshi Kondoh; Wakiko Asayama; Akikazu Asada; Shigemichi. Nishikawa; Kazunari Akiyoshi

  JOURNAL OF BIOTECHNOLOGY, Jan. 2008, Peer-reviewed

  
• Salt effect on the heat-induced association Behavior of gold nanoparticles coated with Poly(N-isopropylacrylamide) prepared via reversible addition - Fragmentation chain transfer (RAFT) radical polymerization

  Shin-Ichi Yusa; Kenichi Fukuda; Tohei Yamamoto; Yasuhiko Iwasaki; Akihiko Watanabe; Kazunari Akiyoshi; Yotaro Morishima

  LANGMUIR, Dec. 2007

  
• Novel thermoresponsive polymers having biodegradable phosphoester backbones

  Yasuhiko Iwasaki; Chookaet Wachiralarpphaithoon; Kazunari Akiyoshi

  MACROMOLECULES, Nov. 2007

  
• Cell-specific delivery of polymeric nanoparticles to carbohydrate-tagging cells

  Yasuhiko Iwasaki; Haruki Maie; Kazunari Akiyoshi

  BIOMACROMOLECULES, Oct. 2007

  
• Selective biorecognition and preservation of cell function on carbohydrate-immobilized phosphorylcholine polymers

  Yasuhiko Iwasaki; Utae Takami; Yurika Shinohara; Kimio Kurita; Kazunari Akiyoshi

  BIOMACROMOLECULES, Sep. 2007

  
• Surface modification with well-defined biocompatible triblock copolymers - Improvement of biointerfacial phenomena on a poly(dimethylsiloxane) surface

  Yasuhiko Iwasaki; Mika Takamiya; Ryoko Iwata; Shin-ichi Yusa; Kazunari Akiyoshi

  COLLOIDS AND SURFACES B-BIOINTERFACES, Jun. 2007

  
• Enzyme-degradable phosphorylcholine porous hydrogels cross-linked with polyphosphoesters for cell matrices

  Chookaet Wachiralarpphaithoon; Yasuhiko Iwasaki; Kazunari Akiyoshi

  BIOMATERIALS, Feb. 2007

  
• Enzyme-responsive micelle-vesicle transition: A new method for the reconstitution of trans-membrane protein to liposome

  Kazunari Akiyoshi; Nobuyuki Morimoto; Akifumi Murota

  2007 INTERNATIONAL SYMPOSIUM ON MICRO-NANO MECHATRONICS AND HUMAN SCIENCE, VOLS 1 AND 2, 2007

  
• Possible molecular evolution of biomembranes: from single-chain to double-chain lipids

  Mari Gotoh; Ayae Sugawara; Kazunari Akiyoshi; Isamu Matsumoto; Guy Ourisson; Yoichi Nakatani

  CHEMISTRY & BIODIVERSITY, 2007

  
• Botryoidal assembly of cholesteryl-pullulan/poly(N-isopropylacrylamide) nanogels

  Nobuyuki Morimoto; Francoise M. Winnik; Kazunari Akiyoshi

  LANGMUIR, Jan. 2007

  
• HER2-specificT-cell immune responses in patients vaccinated with truncated HER2 protein complexed with nanogels of cholesteryl pullulan

  Shigehisa Kitano; Shinichi Kageyama; Yasuhiro Nagata; Yoshihiro Miyahara; Atsunori Hiasa; Hiroaki Naota; Satoshi Okumura; Hiroshi Imai; Taizo Shiraishi; Masahiro Masuya; Masakatsu Nishikawa; Junzo Sunamoto; Kazunari Akiyoshi; Takashi Kanematsu; Andrew M. Scott; Roger Murphy; Eric W. Hoffman; Lloyd J. Old; Hiroshi Shiku

  CLINICAL CANCER RESEARCH, Dec. 2006

  
• Inhibition of the formation of amyloid beta-protein fibrils using biocompatible nanogels as artificial chaperones

  Keisuke Ikeda; Takuma Okada; Shin-ichi Sawada; Kazunari Akiyoshi; Katsumi Matsuzaki

  FEBS LETTERS, Dec. 2006, Peer-reviewed

  
• Highly wettable polyethylene films generated by spontaneous surface enrichment of perfluoroalkylated phosphorylcholines

  Yasuhiko Iwasaki; Kazunari Akiyoshi

  JOURNAL OF APPLIED POLYMER SCIENCE, Nov. 2006

  
• Heat shock protein-like activity of a nanogel artificial chaperone for citrate synthase

  Shin-Ichi Sawada; Yuta Nomura; Yasuhiro Aoyama; Kazunari Akiyoshi

  JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS, Nov. 2006

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• Synthesis and characterization of amphiphilic polyphosphates with hydrophilic graft chains and cholesteryl groups as nanocarriers

  Yasuhiko Iwasaki; Kazunari Akiyoshi

  BIOMACROMOLECULES, May 2006

  
• Platelet separation from whole blood in an aqueous two-phase system with water-soluble polymers

  Emi Sumida; Yasuhiko Iwasaki; Kazunari Akiyoshi; Shohei Kasugai

  JOURNAL OF PHARMACOLOGICAL SCIENCES, May 2006

  
• Self-organaized tubular-linked liposome network

  Shin-ichiro M. Nomura; Kazunari Akiyoshi

  2006 IEEE INTERNATIONAL SYMPOSIUM ON MICRO-NANOMECHATRONICS AND HUMAN SCIENCE, 2006, Peer-reviewed

  
• Controlled adhesion of human lymphocytes on electrically charged polymer surface having phosphorylcholine moiety

  Tomomi Ito; Yasuhiko Iwasaki; Tadashi Narita; Kazunari Akiyoshi; Kazuhiko Ishihara

  SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS, 2003

  
• Gene Expression within Cell-Sized Lipid Vesicles

  Nomura S.-I.M; Tsumoto K; Hamada T; Akiyoshi K; Nakatani Y; Yoshikawa K

  ChemBioChem, 2003, Peer-reviewed

  
• Controlled Association of Hydrophobized Polysaccharide by Cyclodextrin

  AKIYOSHI Kazunari; SASAKI Yoshihiro; KURODA Kenichi; SUNAMOTO Junzo

  Chemistry Letters, Jan. 1998

  
• Self-aggregates of Hydrophobized Polysaccharide as a Host for Macromolecular Guests

  AKIYOSHI Kazunari; NAGAI Kenichi; NISHIKAWA Takehiro; SUNAMOTO Junzo

  Chemistry Letters, 05 Sep. 1992

  
• A Water-Soluble Spin Probe Newly Developed for Liposomal Studies.

  Sunamoto Junzo; Akiyoshi Kazunari; Kihara Tetsuji; Endo Masayuki

  Bull. Chem. Soc. Jpn., 1992

  
• Cell specificity of polysaccharide derivatives on liposomal surface.

  Akiyoshi Kazunari; Takanabe Hidenobu; Sato Tetsuya; Sato Toshinori; Kondo Hiroki; Sunamoto Junzo

  Chemistry Letters, 1990

  
• Structural stability of lecithin liposomes as improved by adding an artificial boundary lipid.

  Sunamoto Junzo; Goto Mitsuaki; Akiyoshi Kazunari

  Chemistry Letters, 1990

  
• Effective transfer of membrane proteins from human erythrocytes to artificial boundary lipid-containing liposomes.

  Sunamoto Junzo; Goto Mitsuaki; Akiyoshi Kazunari

  Chemistry Letters, 1990

  
• Embedding a membrane protein into an enveloped artificial viral replica

  Hiroto Furukawa; Hiroshi Inaba; Yoshihiro Sasaki; Kazunari Akiyoshi; Kazunori Matsuura

  RSC CHEMICAL BIOLOGY, Feb. 2022

  
• Assessment of Surface Glycan Diversity on Extracellular Vesicles by Lectin Microarray and Glycoengineering Strategies for Drug Delivery Applications

  Asako Shimoda; Risako Miura; Hiroaki Tateno; Naohiro Seo; Hiroshi Shiku; Shin-ichi Sawada; Yoshihiro Sasaki; Kazunari Akiyoshi

  SMALL METHODS, Feb. 2022

  
• Protein antigen conjugated with cholesteryl amino-pullulan nanogel shows delayed degradation in dendritic cells and augmented immunogenicity

  Wang Long; Shinji Kunitake; Shin-Ichi Sawada; Kazunari Akiyoshi; Takeshi Tsubata

  VACCINE, Dec. 2021

  
• Construction of Hybrid Cell Spheroids Using Cell-Sized Cross-Linked Nanogel Microspheres as an Artificial Extracellular Matrix

  Shunya Hayashi; Yoshihiro Sasaki; Hirotaka Kubo; Shin-ichi Sawada; Naoya Kinoshita; Eriko Marukawa; Hiroyuki Harada; Kazunari Akiyoshi

  ACS APPLIED BIO MATERIALS, Nov. 2021

  
• Thermoresponsive glycopolymer vesicles: in situ observation of morphological changes and triggered cargo release

  Tomoki Nishimura; Yoshihiro Sasaki; Kazunari Akiyoshi

  POLYMER JOURNAL, Nov. 2021

  
• NOVEL NANOPARTICLE-BASED DELIVERY OF H3.3K27M PEPTIDE TO TUMOR-ASSOCIATED MACROPHAGES ENHANCES THE TUMOR HOMING OF H3.3K27M-TCR TRANSDUCED T-CELLS IN HLA-A2/DR1 TRANSGENIC MICE WITH H3.3K27M(+)

  Akane Yamamichi; Polly Chuntova; Bunta Kakihara; Tiffany Chen; David Diebold; Naozumi Harada; Kazunari Akiyoshi; Hiroshi Shiku; Hideho Okada

  NEURO-ONCOLOGY, Nov. 2021

  
• Design and function of smart biomembrane nanohybrids for biomedical applications: review

  Yoshihiro Sasaki; Kazunari Akiyoshi

  POLYMER JOURNAL, May 2021

  
• Study on magnetic thermal seeds coated with thermal-responsive molecularly imprinted polymers

  Takuya Kubo; Miwa Shimonaka; Yoshiyuki Watabe; Kazunari Akiyoshi; Jeyadevan Balachandran; Koji Otsuka

  NANOCOMPOSITES, Jan. 2021

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• Amphiphilic Poly[poly(ethylene glycol) methacrylate]s with OH Groups in the PEG Side Chains for Controlling Solution/Rheological Properties and toward Bioapplication

  Yuta Koda; Daiki Takahashi; Yoshihiro Sasaki; Kazunari Akiyoshi

  ACS APPLIED BIO MATERIALS, May 2019

  
• Organic-inorganic nanohybrid as magnetically navigated nanocarrier for biologicals

  Yoshihiro Sasaki; Riku Kawasaki; Ryousuke Mizuta; Naoya Kinoshita; Kazunari Akiyoshi

  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Mar. 2019

  
• Immune sensitivity of tumor is governed by the mechanism for differentiation of tumor-associated macrophages (TAMs)

  Daisuke Muraoka; Naohiro Seo; Tae Hayashi; Keisuke Fujii; Hiroaki Ikeda; Kazunari Akiyoshi; Naozumi Harada; Hiroshi Shiku

  CANCER SCIENCE, Dec. 2018

  
• Relationship between diversity of CD8+T cell exosomes and destruction of mesenchymal tumor stroma

  Naohiro Seo; Tsuguhiro Kaneda; Junko Nakamura; Fumiyasu Momose; Kazunari Akiyoshi; Hiroshi Shiku

  CANCER SCIENCE, Dec. 2018

  
• Activated CD8+T cells interrupt tumor invasion and metastasis in exosome-dependent manners

  Naohiro Seo; Junko Nakamura; Kazunari Akiyoshi; Hiroshi Shiku

  CANCER SCIENCE, Jan. 2018

  
• On-demand control of antimicrobial activity of methacrylate random copolymers using amphiphilic polysaccharide nanogel

  Haruko Takahashi; Kazunari Akiyoshi; Kenichi Kuroda

  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2014

  
• High Hydrostatic Pressurized Lipoplex Enhances Transfection Efficiency In Vitro

  Tsuyoshi Kimura; Yukie Kanda; Asami Sano; Kwangwoo Nam; Yoshihiro Sasaki; Kazunari Akiyoshi; Toshiya Fujisato; Akio Kishida

  ADVANCED BIOMEDICAL ENGINEERING, 2013

  
• Preparation of protein-crosslinked nanogels with pyridoxal-bearing polysaccharide for potential biomedical applications

  Yoshihiro Sasaki; Yuji Tsuchido; Shin-ichi Sawada; Kazunari Akiyoshi

  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Mar. 2012

  
• Intracellular protein delivery with self-assembled cationic nanogels

  Kazunari Akiyoshi; Hirohito Ayame; Nobuyuki Morimoto

  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2008

  
• PMSE 126-Comparative study of responsive nanogels using the temperature responsive properties of poly(N-isopropylacrylamides) and poly-(2-isopropyl-2-oxazolines) in water

  Nobuyuki Morimoto; Kazunari Akiyoshi; Francoise M. Winnik

  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2008

  
• POLY 187-Design of dual stimuli-responsive nanogels by self-assembly of thiol-terminated poly(n-isopropylacrylamide)-graft pullulan

  Nobuyuki Morimoto; Francoise M. Winnik; Kazunari Akiyoshi

  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2008

  
• Drug delivery with polymeric nanoparticles through cell surface tags

  Yasuhiko Iwasaki; Haruki Maie; Kazunari Akiyoshi

  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2007

  
• POLY 219-Oriented immobilization of antibody fragments on polymer brushes for highly sensitive biorecognition

  Ryoko Iwata; Yasuhiko Iwasaki; Kazunari Akiyoshi

  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2007

  
• POLY 408-Nanogels of hydrophobized dendritic polysaccharide and interaction with proteins

  Yayoi Ozawa; Nobuyuki Morimoto; Kazunari Akiyoshi

  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2007

  
• Lipid-tubular network formation for biochemical reaction

  Shin-ichiro M. Nomura; Kazunari Akiyoshi

  2007 INTERNATIONAL SYMPOSIUM ON MICRO-NANO MECHATRONICS AND HUMAN SCIENCE, VOLS 1 AND 2, 2007

  
• POLY 229-Nanogel engineering for DDS: Cationic polysaccharide nanogels for intracellular protein or quantum dot delivery

  Kazunari Akiyoshi; Hirohito Ayame; Urara Hasegawa; Sayaka Toita; Wakiko asayama; Nobuyuki Morimoto

  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Sep. 2006

  
• POLY 275-Temperature-dependence of the structure and association of cholesteryl-modified pullulan-poly-(N-isopropylacrylamide) hybrid nanogels

  Nobuyuki Morimoto; Xing-Ping Qiu; Francoise M. Winnik; Kazunari Akiyoshi

  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Sep. 2006

  
• POLY 422-Nanogel-inorganic hybrid: Synthesis of polysaccharide-calcium phosphate nanomaterials

  Setsuko Yamane; Ayae Sugawara; Kazunari Akiyoshi

  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Sep. 2006

  
• Enzymatic synthesis and characterization of hydrophobized poly (L-lysine)-amylose conjugates

  Kazunari Akiyoshi; Mio Yamazaki; Noriyuki Morimoto

  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Mar. 2006

  
• Design of biodegradable amphiphilic polyphosphates with well-defined hydrophilic graft chains

  Yasuhiko Iwasaki; Kazunari Akiyoshi

  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Mar. 2006

  
• A Molecular Communication Interface Using Liposomes with Gap Junction Proteins

  Yuki Moritani; Shin-ichiro M. Nomura; Satoshi Hiyama; Kazunari Akiyoshi; Tatsuya Suda

  2006 1ST BIO-INSPIRED MODELS OF NETWORK, INFORMATION AND COMPUTING SYSTEMS, 2006

  

Misc.

• Bio-membrane Inspired Science and Application to Nanomedicine

  秋吉一成

  膜, 2024

  
• Design and function of glycan Hybrid nanomaterials

  秋吉一成

  生化学, 2024

  
• ヒアルロン酸ナノゲルを基盤とした新規架橋ゲルの創製とin vitroにおけるTHP-1細胞を用いた炎症性評価

  藪内昂平; 藪内昂平; 鈴木美加; 梁忱; 勝又徹; 下房地剛; 橋本良秀; 木村剛; 秋吉一成; 岸田晶夫

  日本再生医療学会総会(Web), 2024

  
• HHP処理細胞を用いた人工細胞外小胞の調製とその生医学応用

  海田こころ; 木村剛; 橋本良秀; 秋吉一成; 佐々木善浩; 岸田晶夫

  日本再生医療学会総会(Web), 2024

  
• Design and Function of Nanogel Network Materials: Applications in Drug Delivery Systems and Artificial Extracellular Matrices

  下田麻子; 秋吉一成

  ネットワークポリマー論文集, 2024

  
• バイオインスパイアードナノ組織体の設計とバイオ・医療応用

  秋吉 一成

  ペトロテック = Petrotech : 石油学会情報誌 / 石油学会 編, Dec. 2023

  
• 自己組織化ナノゲルDDSを用いたワクチン開発 : 日本発タンパク質抗原DDS搭載ワクチンの開発を目指して—特集 次世代医療を支えるDDSの進展

  秋吉 一成

  化学と工業 = Chemistry & chemical industry, Feb. 2023

  
• 細胞外小胞・エクソソーム工学:ハイブリッド小胞の構築とイメージングフローサイトメーターによる単粒子解析と機能評価

  秋吉一成

  日本DDS学会学術集会プログラム予稿集, 2023

  
• 脱細胞化脳・胎盤由来マトリクス結合型ナノベシクル(MBV)の抽出と神経機能修復への効果検討

  小林真子; 山本雅哉; 石田直樹; 橋本良秀; 根岸淳; 木村剛; 岸田晶夫; 根岸淳; 佐々木善浩; 秋吉一成

  北海道外科雑誌, 2023

  
• Molecular mechanism of the drug delivery targeted to tumor-associated macrophages by cholesteryl pullulan nanogels

  中司交明; 中司交明; 中司交明; 村岡大輔; 村岡大輔; 安井潔; 原田直純; 澤田晋一; 秋吉一成; 永安武; 池田裕明

  日本癌学会学術総会抄録集(Web), 2023

  
• Mechanistic analysis of T cells responsible for effective ACT for tumors with heterogeneous expression of target antigen

  とう思拓; 村岡大輔; 村岡大輔; 中司交明; 中司交明; 安井潔; 原田直純; 澤田晋一; 秋吉一成; 池田裕明

  日本癌学会学術総会抄録集(Web), 2023

  
• 膜傷害性ペプチド修飾多糖と抗体による複合体形成と抗体のサイトゾル送達

  道端惇也; 佐々木善浩; 秋吉一成; 二木史朗

  生体膜と薬物の相互作用シンポジウム講演要旨集, 2023

  
• Tumor-associated macrophage-targeted drug delivery to overcome tumor immune resistance

  原田直純; 溝口菜美; 松元彩香; 田代純輝; 長谷田泰成; 井上義; 曽我孝利; 村岡大輔; 山道茜; 岡田秀穂; 澤田晋一; 秋吉一成

  日本薬学会年会要旨集(Web), 2023

  
• Development of vaccine using self-assembled nanogel DDS

  秋吉一成; 澤田晋一; 佐々木善浩

  日本化学繊維研究所講演集(Web), 2023

  
• Liquid-liquid phase separation formation by macromolecule delivery peptides bearing polysaccharides and its application for cytosolic antibody delivery.

  道端惇也; 佐々木善浩; 秋吉一成; 二木史朗

  日本薬学会年会要旨集(Web), 2023

  
• Bone tissue regeneration using nanogel-cross linked-porous freeze-dried gel that regulates orientation of hydroxyapatite

  足立哲也; 足立哲也; 田原義朗; 今村隼大; 今村隼大; 山本俊郎; 松田修; PEZZOTTI Giuseppe; PEZZOTTI Giuseppe; 秋吉一成; 金村成智

  日本バイオマテリアル学会大会予稿集(Web), 2023

  
• Preparation of an artificial extracellular vesicle using high-hydrostatic pressurized cell.

  海田こころ; 木村剛; 橋本良秀; 秋吉一成; 佐々木善浩; 岸田晶夫

  日本バイオマテリアル学会大会予稿集(Web), 2023

  
• Development and evaluation of hybrid nanogels composing of carborane-containing polysaccharides and hydrophobic boron oxide nanoparticles for BNCT

  平野英寿; 河崎陸; 山名啓太; 真田悠生; 坂東香里; 田畑杏梨; 高田卓志; 櫻井良憲; 鈴木実; 樽谷直紀; 片桐清文; 佐々木善浩; 秋吉一成; 長崎健; 池田篤志

  日本バイオマテリアル学会大会予稿集(Web), 2023

  
• 3D direct conversion into functional osteoblasts and nanogel tectonic engineering for bone regeneration

  山本健太; 田原義朗; 岸田綱郎; 秋吉一成; 松田修

  日本バイオマテリアル学会大会予稿集(Web), 2023

  
• Development of Hybrid Nanogels with Highly Integrated Boron Oxide Nanoparticle and Evaluation of Their Biofunction

  河崎陸; 平野英寿; 山名啓太; 真田悠生; 坂東香里; 田畑杏梨; 櫻井良憲; 田中浩基; 鈴木実; 澤田晋一; 佐々木善浩; 秋吉一成; 長崎健; 池田篤志

  ホスト-ゲスト・超分子化学シンポジウム講演要旨集, 2023

  
• バイオ医療応用に向けたナノゲル工学とエクソソーム工学

  秋吉 一成

  03 Oct. 2022

  
• Development of a rapid subclass separation technique for diversity analysis of extracellular vesicles

  金尾英佑; 金尾英佑; 和田俊太郎; 久保拓也; 大塚浩二; 秋吉一成; 足立淳; 足立淳; 石濱泰; 石濱泰

  日本薬学会年会要旨集(Web), 2022

  
• 無細胞タンパク質発現/リポソーム系を用いた1段階KcsA組込みリポソームの構築と機能解析

  安藤満; 安藤満; 秋山源; 奥野大地; 平野美奈子; 井出徹; 澤田晋一; 澤田晋一; 佐々木善浩; 秋吉一成; 秋吉一成

  日本膜学会年会講演要旨集, 2015

  
• ナノマテリアルを用いた新規腎癌治療の開発と免疫機構の解析

  藤井秀岳; 藤井秀岳; 新屋政春; 大石正勝; 上田崇; 中西弘之; 中村晃和; 本郷文弥; 納谷佳男; 沖原宏治; 秋吉一成; 松田修; 三木恒治

  日本泌尿器科学会総会プログラム抄録集(CD-ROM), 2015

  
• ナノマテリアルを用いた新規腎癌治療の開発(A development of new renal carcinoma treatment using the nano-material)

  藤井 秀岳; 新屋 政春; 大石 正勝; 上田 崇; 中西 弘之; 中村 晃和; 本郷 文弥; 納谷 佳男; 沖原 宏治; 秋吉 一成; 松田 修; 三木 恒治

  日本癌学会総会記事, Sep. 2014

  
• ソフトナノチューブ工学:脂質膜牽引法によるナノチューブの形成制御

  佐々木善浩; 吉竹広記; 小齊拓人; 秋吉一成; 秋吉一成

  バイオ・高分子シンポジウム講演要旨集, 2014

  
• 蛍光ナノ粒子を用いた細胞内脂肪滴の三次元可視化法を適用した脂肪細胞の分化誘導と肥満モデル動物における脂肪蓄積過程の解析

  横田一成; 小川智史; 秋吉英雄

  島根大学生物資源科学部研究報告(Web), 2012

  
• ナノゲル工学とシャペロン機能工学

  秋吉 一成

  日本臨牀 64, 2006

  
• 再生医療のためのドラッグデリバリーシステム(特別講演,第3回日本再生歯科医学会学術大会および総会)

  秋吉 一成

  日本再生歯科医学会誌, 30 Dec. 2005

  
• Hybrid nanogels with physical and chemical cross-linking structures as nanocarriers.

  秋吉 一成

  Macromolecular Bioscience Vol.5(8), 2005

  
• Selective cell attachment to a biomimetic polymer surface through the recognition of cell-surface tags

  Iwasaki, Y; Tabata, E; Kurita, K; Akiyoshi, K

  Bioconjugate Chemistry, 2005

  
• ナノゲルバイオマテリアル: DDSと人工分子シャペロン

  秋吉 一成

  口腔病学会雑誌, 2004

  
• 【展望講演】ナノゲルを用いた人工シャペロン系の開発

  秋吉 一成

  化学工学会 研究発表講演要旨集, 2003

  
• 脂質ナノチューブーナノゲルハイブリッドの作製と機能

  小齊拓人; 吉竹広記; 澤田晋一; 向井貞篤; 佐々木善浩; 秋吉一成

  日本化学会春季年会講演予稿集(CD-ROM), 2016

  
• 生体膜ナノチューブ固定化ヒドロゲルの設計とバイオ機能

  吉竹広記; 澤田晋一; 澤田晋一; 佐々木善浩; 秋吉一成; 秋吉一成

  高分子学会予稿集(CD-ROM), 2015

  
• 膜モルフォジェネシスによる物質送達ソフトナノチューブの構築と機能

  佐々木善浩; 吉竹広記; 小斎拓人; 澤田晋一; 向井貞篤; 秋吉一成; 澤田晋一; 向井貞篤; 秋吉一成

  日本DDS学会学術集会プログラム予稿集, 2015

  
• 生体模倣脂質ナノチューブの形成制御とバイオ応用

  吉竹広記; 小齊拓人; 澤田晋一; 澤田晋一; 佐々木善浩; 秋吉一成; 秋吉一成

  高分子学会予稿集(CD-ROM), 2015

  
• 多糖ナノゲル-脂質ナノチューブハイブリッドの設計と機能

  小齊拓人; 吉竹広記; 澤田晋一; 澤田晋一; 向井定篤; 向井定篤; 佐々木善浩; 秋吉一成; 秋吉一成

  高分子学会予稿集(CD-ROM), 2015

  
• コロイド微粒子による膜モルフォジェネシスの制御とバイオマテリアル応用

  佐々木善浩; 小齊拓人; 吉竹広記; 竹谷以紀; 澤田晋一; 澤田晋一; 秋吉一成; 秋吉一成

  高分子学会予稿集(CD-ROM), 2015

  
• ナノ微粒子マニュピレーションによるソフトマテリアルの創発とバイオ機能

  佐々木善浩; 河崎陸; 片桐清文; 竹谷以紀; 小齊拓人; 吉竹広記; 澤田晋一; 澤田晋一; 向井貞篤; 向井貞篤; 秋吉一成; 秋吉一成

  高分子学会予稿集(CD-ROM), 2015

  
• ナノ微粒子泳動法によるバイオナノチューブの形成制御

  吉竹広記; 澤田晋一; 澤田晋一; 佐々木善浩; 秋吉一成; 秋吉一成

  高分子学会予稿集(CD-ROM), 2014

  
• 脂質ナノチューブヒドロゲルハイブリッドの開発と機能

  吉竹広記; 佐々木善浩; 澤田晋一; 秋吉一成

  バイオ・高分子シンポジウム講演要旨集, 2014

  
• 脂質ナノチューブの新規構築法の開発と機能

  吉竹広記; 澤田晋一; 澤田晋一; 佐々木善浩; 秋吉一成; 秋吉一成

  高分子学会予稿集(CD-ROM), 2014

  
• Nanogel Engineering for Development of Novel Immunotherapy and Regenerative medicine

  足立哲也; 足立哲也; 田原義朗; 宮本奈生; 新屋政春; 山本俊郎; PEZZOTTI Giuseppe; 秋吉一成; 松田修; 金村成智

  砥粒加工学会学術講演会講演論文集(CD-ROM), 2022

  
• エクソソームによる異種生物間のコミュニケーションと疾患—Cell-to-cell communications among different species by exosomes and their roles in diseases—特集 エクソソームと疾患 : そして臨床応用ヘ

  下田 麻子; 秋吉 一成

  細胞, Jan. 2016

  
• Amphiphilic block copolymer with a molecular recognition site: Induction of a novel binding characteristic of amylose by self-assembly of poly(ethylene oxide)-block-amylose in chloroform

  K Akiyoshi; N Maruichi; M Kohara; S Kitamura

  BIOMACROMOLECULES, Mar. 2002

  
• バイオクロスリンカーとしてのビタミンB₆置換ポリマーの設計と機能

  佐々木善浩; 土戸優志; 澤田晋一; 澤田晋一; 秋吉一成; 秋吉一成

  日本バイオマテリアル学会大会予稿集, 2013

  
• タンパク質-多糖ハイブリッドナノゲルの作製と機能

  佐々木善浩; 土戸優志; 澤田晋一; 澤田晋一; 秋吉一成; 秋吉一成

  高分子学会予稿集(CD-ROM), 2013

  
• ビタミンB6置換多糖によるタンパク質架橋ナノゲルの作製と機能

  佐々木善浩; 土戸優志; 由井伸彦; 澤田晋一; 秋吉一成; 秋吉一成

  日本DDS学会学術集会プログラム予稿集, 2012

  
• ビタミンB₆エンジニアリング:ナノゲル化酵素の作製と機能

  土戸優志; 土戸優志; 佐々木善浩; 由井伸彦; 澤田晋一; 澤田晋一; 秋吉一成; 秋吉一成; 秋吉一成

  バイオ・高分子シンポジウム講演要旨集, 2012

  
• ビタミンB₆エンジニアリング:ビタミンB₆置換多糖によるタンパク質の熱安定化

  土戸優志; 土戸優志; 佐々木善浩; 佐々木善浩; 由井伸彦; 澤田晋一; 澤田晋一; 秋吉一成; 秋吉一成; 秋吉一成

  高分子学会予稿集(CD-ROM), 2012

  
• ビタミンB₆置換プルランによるタンパク質ナノキャリアの設計

  土戸優志; 土戸優志; 佐々木善浩; 由井伸彦; 澤田晋一; 澤田晋一; 秋吉一成; 秋吉一成; 秋吉一成

  高分子学会予稿集(CD-ROM), 2012

  
• タンパク質架橋ナノゲルの作製

  土戸優志; 土戸優志; 佐々木善浩; 秋吉一成; 秋吉一成; 秋吉一成

  日本化学会講演予稿集, 2011

  
• ビタミンB₆エンジニアリング:タンパク質架橋ナノゲルの設計と機能

  土戸優志; 土戸優志; 佐々木善浩; 佐々木善浩; 由井伸彦; 澤田晋一; 秋吉一成; 秋吉一成

  高分子学会予稿集(CD-ROM), 2011

  
• タンパク質架橋ナノゲルの機能評価

  土戸優志; 土戸優志; 佐々木善浩; 佐々木善浩; 秋吉一成; 秋吉一成

  バイオ・高分子シンポジウム講演要旨集, 2011

  
• ビタミンB₆-多糖コンジュゲートのナノゲル形成と機能評価

  土戸優志; 佐々木善浩; 秋吉一成

  日本化学会講演予稿集, 2010

  
• ビタミンB₆置換プルランのナノゲル形成と機能

  土戸優志; 佐々木善浩; 秋吉一成; 秋吉一成

  高分子学会予稿集(CD-ROM), 2010

  
• タンパク質を架橋点とする動的ナノゲルの作製

  土戸優志; 土戸優志; 佐々木善浩; 秋吉一成; 秋吉一成

  高分子学会予稿集(CD-ROM), 2010

  
• ビタミンB₆-多糖コシジュゲートナノゲルの作製と機能評価

  土戸優志; 土戸優志; 佐々木善浩; 秋吉一成; 秋吉一成

  バイオ・高分子シンポジウム講演要旨集, 2010

  
• Synthesis and Function of Vitamin B6-bearing Polysaccharide

  TSUCHIDO Yuji; SASAKI Yoshihiro; AKIYOSHI Kazunari; AKIYOSHI Kazunari

  高分子学会予稿集(CD-ROM), 2009

  
• Design and Synthesis of Dynamic Bioconjugator Targeting Amines

  土戸優志; 佐々木善浩; 秋吉一成

  日本化学会講演予稿集, 2009

  
• ビタミンB₆-多糖コンジュゲートの設計と機能

  土戸優志; 佐々木善浩; 秋吉一成; 秋吉一成

  高分子学会予稿集(CD-ROM), 2009

  
• Function of in situ synthesized membrane protein in the presence of cell-size liposome

  Wakiko Asayama; Wakiko Asayama; Satoshi Kondoh; Shin Ichiro M Nomura; Shin Ichiro M Nomura; Kazunari Akiyoshi; Kazunari Akiyoshi

  Polymer Preprints, Japan, 19 Oct. 2006

  
• Characteristics of nanogel-DNA complexes

  Shin Ichi Sawada; Naomi Miyazawa; Shin Ichiro M Nomura; Kazunari Akiyoshi

  Polymer Preprints, Japan, 01 Dec. 2005

  
• Structural Analysis of DDS Nanocarriers by Neutron and X-ray Small-angle Scattering Measurements

  西村智貴; 秋吉一成; 関根由莉奈

  波紋, 2020

  
• ナノDrug Delivery System(DDS)を用いた新規腎癌治療の開発

  藤井秀岳; 藤井秀岳; 新屋政春; 本郷文弥; 大石正勝; 上田崇; 中村晃和; 納谷佳男; 秋吉一成; 松田修; 三木恒治

  日本泌尿器科学会総会プログラム抄録集(CD-ROM), 2014

  
• 抗腫よう免疫療法を目指したIL-12・ナノパーティクルの基礎検討

  清水健; 上田祐二; 岸田綱郎; 長谷川麗; 新屋政春; 秋吉一成; 松田修; 山岸久一

  Biotherapy (Tokyo), 2005

  
• Self-assembled polysaccharide nanogels for nasal delivery of biopharmaceuticals

  Tomonori Nochi; Yoshikazu Yuki; Kazunari Akiyoshi; Hiroshi Kiyono

  Mucosal Delivery of Biopharmaceuticals: Biology, Challenges and Strategies, 01 Oct. 2014

  
• Nanogel-based pneumococcal surface protein A (PspA) intranasal vaccine: the effective delivery system of antigen across the nasal mucosal barrier

  Kong, I; A. Sato; S. Sato; T. Nochi; E. J. Park; Y. Yuki; H. Takahashi; S. Sawada; D. E. Briles; M. Yamamoto; K. Akiyoshi; H. Kiyono

  ALLERGY, Sep. 2014

  
• Introduction of stimuli-responsive polymer onto the surface of gold nanoparticles and their association behavior in water

  Kenichi Fukuda; Shin Ichi Yusa; Makoto Sugahara; Tohei Yamamoto; Yotaro Morishima; Kazunari Akiyoshi; Yasuhiko Iwasaki; Akihiko Watanabe

  Polymer Preprints, Japan, 18 Oct. 2006

  
• Stimuli-responsive aggregation of hybrid organic-inorganic nanoparticles

  Kenichi Fukuda; Shin Ichi Yusa; Makoto Sugahara; Tohei Yamamoto; Yotaro Morishima; Kazunari Akiyoshi; Yasuhiko Iwasaki; Akihiko Watanabe

  Polymer Preprints, Japan, 01 Dec. 2005

  
• TEM Observation on the Hybrid Layer of Dentin bonded with SuperBond Quick

  ZENG Weiping; SHIMOZONO Akari; WATANABE Akihiko; AKIYOSHI Kazunari

  日本歯科保存学雑誌, 07 Oct. 2003

  
• 象牙質の接着:被着体の解析と長期接着安定性

  渡辺 昭彦; 秋吉 一成

  生体材料工学研究所報告, 2002

  
• Self-assembly of Hydrophobized Polymer and Funcion of the Nanoparticle

  AKIYOSHI Kazunari

  高分子学会予稿集, 10 May 1996

  
• Nanogel-inorganic hybrid materials: preparation of calcium phosphate nanoparticles

  山根 説子; 菅原 彩絵; 秋吉 一成

  Annual reports of the Institute of Biomaterials and Bioengineering, 2007

  
• 疎水化多糖ナノゲルを用いた人工分子シャペロンの開発

  野村 雄太; 澤田 晋一; 秋吉 一成

  生体材料工学研究所報告, 2003

  
• Constructing functional cell model: cell-sized liposome engineering

  野村 M. 慎一郎; 朝山 和喜子; 秋吉 一成

  Annual reports of the Institute of Biomaterials and Bioengineering, 2006

  
• 12.P 骨芽細胞様細胞の接着及び遊走に対するエレクトロベクトル効果の影響(ポスター発表,第3回日本再生歯科医学会学術大会および総会)

  中村 美穂; 中村 聡; 関島 安隆; 小林 孝之; 秋吉 一成; 岩崎 泰彦; 山下 仁大

  日本再生歯科医学会誌, 30 Dec. 2005

  
• 19.P CHP(コレステロール置換型プルラン)ナノゲルの創傷治癒に対する有効性(ポスター発表,第3回日本再生歯科医学会学術大会および総会)

  小林 裕史; 片倉 修; 角田 愛美; 森本 展行; 岩崎 泰彦; 秋吉 一成; 春日井 昇平

  日本再生歯科医学会誌, 30 Dec. 2005

  
• Synthesis and Characterization of Porous Phosphorylcholine Polymer Hydrogel Cross-Linked with Methacryloyl-Functionalized Polyphosphates

  WACHIRALARPPHAITHOON Chookaet; IWASAKI Yasuhiko; AKIYOSHI Kazunari

  Journal of the Japanese Society for Dental Materials and Devices, 05 Sep. 2005

  
• 14aPS-88 Lipid Nanotubular Network Connection : giant liposome organization

  Nomura Shinichiro; Akiyoshi K.; Motoike Ikuko

  Meeting abstracts of the Physical Society of Japan, 25 Aug. 2004

  
• Inhibition of Amyloid β Peptide Fibril Formation by Hydrogel Nanoparticles

  IKEDA Keisuke; SAWADA Shinichi; AKIYOSHI Kazunari; MATSUZAKI Katsumi

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2006

  
• Development of artificial cell array for construction of biochips

  佐々木 善浩; 秋吉 一成

  Annual reports of the Institute of Biomaterials and Bioengineering, 2009

  
• A novel hydrophobized polysaccharide/oncoprotein complex vaccine induces in vitro and in vivo cellular and humoral immune responses against HER2-expressing murine sarcomas

  XG Gu; M Schmitt; A Hiasa; Y Nagata; H Ikeda; Y Sasaki; K Akiyoshi; J Sunamoto; H Nakamura; K Kuribayashi; H Shiku

  CANCER RESEARCH, Aug. 1998

  
• 多糖ナノゲル架橋ハイブリッド材料の設計と機能

  秋吉 一成; 橋本 良秀; 澤田 晋一

  日本化学繊維研究所講演集 Annual report of the Research Institute for Chemical Fibers, Japan, 2015

  
• ナノゲルテクトニクス : 多糖ナノゲルによる新規バイオマテリアル創製と医療応用 (特集 ゲル微粒子 : ソフトな微粒子が醸し出す豊かな機能)

  佐々木 善浩; 秋吉 一成

  化学と工業 = Chemistry & chemical industry, Jun. 2015

  
• 疎水化多糖類の溶液内挙動と機能発現

  砂本 順三; 秋吉 一成; 出口 茂

  日本化学繊維研究所講演集, Nov. 1996

  
• Diversity analysis of exosomes and application to DDS

  秋吉一成

  日本薬学会年会要旨集(Web), 2021

  
• Glycan profiles of extracellular vesicles for their diversity classification and function

  下田麻子; 秋吉一成

  実験医学, 2021

  
• Extracellular vesicle hybrid engineering for DDS and medical application

  水田涼介; 秋吉一成

  Drug Delivery System, 2021

  
• エクソソームのサブクラス分離へ向けたレクチン固定化スポンジ基材の開発

  久保 拓也; 加藤 誠也; 下田 麻子; 石川 良賀; 澤田 晋一; 佐々木 善浩; 秋吉 一成; 大塚 浩二

  分析化学, Dec. 2020

  
• Glycomics of extracellular vesicles, exosomes

  下田麻子; 秋吉一成

  生化学, Jun. 2020

  
• 【バイオ医薬とDDS】ナノゲル抗原DDSによる免疫療法抵抗性がんの克服に向けて

  原田 直純; 村岡 大輔; 珠玖 洋; 秋吉 一成

  Drug Delivery System, Jan. 2020

  
• 医療を支える新素材 12 高分子ミセル・ナノゲルで薬を届ける-医療で使えるナノキャリア-

  三浦理紗子; 秋吉一成

  現代化学, 2020

  
• Design of glyco polymer vesicles and their function as DDS nanofactories

  西村智貴; 秋吉一成

  Drug Delivery System, Jul. 2019

  
• Preparation and function of hybrid nanoparticles with artificial cell membrane

  井上文仁; 澤田晋一; 向井貞篤; 佐々木善浩; 秋吉一成

  日本バイオマテリアル学会大会予稿集(Web), 2019

  
• 細胞外小胞,エクソソームの特性と機能

  下田麻子; 秋吉一成

  Dojin News, 2019

  
• Nanogel Tectonics for Tissue Engineering: Protein Delivery Systems with Nanogel Chaperones

  Yoshihide Hashimoto; Sada-atsu Mukai; Yoshihiro Sasaki; Kazunari Akiyoshi

  ADVANCED HEALTHCARE MATERIALS, Dec. 2018, Peer-reviewed, Invited

  
• 【エクソソーム最前線】エクソソーム糖鎖とその機能

  下田 麻子; 秋吉 一成

  炎症と免疫, Jun. 2018

  
• 分子シャペロン機能をもつ人工分子システム:シャペロン機能工学

  西村智貴; 秋吉一成

  CSJ Current Review, 2018

  
• Antigen delivery system by using self-assembled nanogel

  三浦 理紗子; 秋吉 一成

  細胞, Oct. 2017

  
• 微粒子等を用いたドラッグデリバリーシステム

  田原義朗; 秋吉一成

  動物用ワクチンとバイオ医薬品, Jul. 2017, Invited

  
• 自己組織化ナノゲルによるDDS開発

  田原義朗; 秋吉一成

  月刊ファインケミカル, Nov. 2016, Invited

  
• グライコテクトニクスによる新規バイオ材料の設計と機能

  秋吉 一成; 西村 智貴; 澤田 晋一

  日本化学繊維研究所講演集 Annual report of the Research Institute for Chemical Fibers, Japan, 2016

  
• “DDS研究・開発に有用な試薬”第6回 タンパク質導入試薬

  河崎陸; 佐々木善浩; 秋吉一成

  Drug Delivery System, 2016

  
• エクソソームと疾患-そして臨床応用へ-【エクソソームによる異種生物間のコミュニケーションと疾患】

  下田麻子; 秋吉一成; 下田麻子; 秋吉一成

  月刊細胞, 2016

  
• 物理架橋ナノゲルの調製とDDS応用

  田原義朗; 秋吉一成

  DDSキャリア作製プロトコル集, Aug. 2015, Invited

  
• Pullulan

  Yoshiro Tahara; Kazunari Akiyoshi

  Encyclopedia of polymeric nanomaterials, Jun. 2015, Invited

  
• 8pPSB-15 Controlling a Drying Pattern of Colloidal Dispersions by Non-equilibrium Conditions

  Mukai S.; Hahsimoto Y.; Tahara Y.; Sawada S.; Akiyoshi K.

  Meeting abstracts of the Physical Society of Japan, 22 Aug. 2014

  
• ナノゲル工学による新規タンパク質DDSの開発と医療応用

  秋吉一成; 秋吉一成

  Drug Delivery System, 2014

  
• Artificial Molecular Chaperone System

  SASAKI Yoshihiro; AKIYOSHI Kazunari

  高分子, 01 Sep. 2013

  
• ナノゲル基盤材料によるタンパク質医薬の徐放技術とその応用

  田原義朗; 秋吉一成

  遺伝子医学MOOK別冊 – ここまで広がるドラッグ徐放技術の最前線 –, Mar. 2013, Invited

  
• 学会ポータルサイトの構築に向けて

  秋吉 一成

  高分子, 01 Dec. 2012

  
• 新規多糖ナノゲルの設計とバイオ応用

  秋吉 一成; 澤田 晋一

  日本化学繊維研究所講演集, Mar. 2012

  
• Design of New Biomaterials by Nanogel Engineering and Biomedical Applications

  向井貞篤; 向井貞篤; 秋吉一成; 秋吉一成

  Pharm Tech Japan, 2012

  
• Utilization of cell structures extracellular vesicles secreted from a cell: function and application of exosomes

  澤田晋一; 澤田晋一; 佐藤祐子; 佐藤祐子; 秋吉一成; 秋吉一成

  バイオマテリアル, 2012

  
• リポソーム膜上における膜蛋白質への蛍光性アミノ酸導入およびその挙動解析法の開発

  大塚巧磨; 根木慧; 金井保; 秋吉一成; 野村M.新一郎; 野村M.新一郎; 大槻高史

  生化学, 2011

  
• 無細胞タンパク質発現系によるプロテオリポソームの構築と機能

  安岡潤一; 安岡潤一; 澤田晋一; 由井伸彦; 秋吉一成; 秋吉一成; 秋吉一成

  生化学, 2011

  
• カドヘリン再構成リポソームの構築と機能

  神谷 厚輝; 湊元 幹太; 吉村 哲郎; 秋吉 一成

  Drug Delivery System, 2011

  
• Glycogen nano-ball for polysaccharide nanogel engineering

  Haruko Takahashi; Shin-ichi Sawada; Kazunari Akiyoshi

  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2010

  
• GFP synthesis in giant liposomes using the in vitro translation system of Thermococcus kodaks

  Kazuaki Yamaji; Tamotsu Kanai; Shin Ichiro; M. Nomura; Kazunari Akiyoshi; Makiko Negishi; Haruyuki Atomi; Kenichi Yoshikawa; Tadayuki Imanaka

  20th Anniversary MHS 2009 and Micro-Nano Global COE - 2009 International Symposium on Micro-NanoMechatronics and Human Science, 01 Dec. 2009

  
• Design of New Nanobiomaterials by Nanogel Engineering

  SASAKI Yoshihiro; AKIYOSHI Kazunari

  高分子, 01 Oct. 2009

  
• スフィンゴシンキナーゼ2阻害剤による細胞崩壊の促進

  横山 三紀; 寺澤 和恵; 渡辺 昭彦; 秋吉 一成; 五十嵐 靖之; 平林 義雄; 柳下 正樹

  脂質生化学研究, 10 Jul. 2009

  
• Research Group on Polymers and Biosciences

  AKIYOSHI Kazunari

  高分子, 01 May 2009

  
• Biopolymer-based hydrogel as DDS

  SASAKI Yoshihiro; AKIYOSHI Kazunari

  Journal of Japanese Society for Biomaterials, 18 Nov. 2008

  
• 平成18・19年度日本歯科理工学会教育検討委員会報告書

  楳本 貢三; 岡崎 正之; 小園 凱夫; 宮崎 隆; 平野 進; 荒木 吉馬; 高橋 英和; 河合 達志; 鈴木 一臣; 石川 邦夫; 大野 弘機; 亘理 文夫; 奥野 攻; 長山 克也; 中嶌 裕; 西山 典宏; 小田 豊; 吉田 隆一; 西山 實; 山下 仁大; 高久田 和夫; 秋吉 一成; 塙 隆夫; 宮川 修; 小倉 英夫; 伊藤 充雄; 土井 豊; 宮川 行男; 福井 壽男; 中村 正明; 浅岡 憲三; 堤 定美; 久常 邦博; 伴 清治

  歯科材料・器械, 25 May 2008

  
• 分子シャペロン機能工学によるタンパク質の集積、機能制御

  秋吉 一成

  Drug delivery system, 10 May 2008

  
• ナノゲルDDS研究の最前線(最前線,<ミニ特集>これからの治験)

  森本 展行; 秋吉 一成

  ファルマシア, 2008

  
• Design of nanogel-crosslinked hydrogel and application to biotechnology and medicine

  森本 展行; 秋吉 一成

  Annual reports of the Institute of Biomaterials and Bioengineering, 2008

  
• P18. Effect of CHP (cholesterol-bearing pullulan) - nanogel /prostaglandin E1 on wound healing(Poster Presentation,The 5^ Annual Meeting of Japanese Association of Regeneration Dentistry)

  Kobayashi Hiroshi

  Journal of the Japanese Association of Regenerative Dentistry, 30 Dec. 2007

  
• Drug delivery systems by nanogel engineering

  長谷川 麗; 秋吉 一成

  Cell technology., Jun. 2007

  
• 医歯工連携 : 工学の立場から

  秋吉 一成

  齒學 = Odontology, 30 Mar. 2007

  
• Effect of Rubbing Protein Deposits on Ionic Hydrophilic Soft Contact Lenses

  SHIMIZU Kentarou; SANO Kenji; SHIBATA Yuko; KUROISHIKAWA Makoto; SASAKI Shuji; MOCHIZUKI Manabu; AKIYOSHI Kazunari

  Journal of Japan Contact Lens Society, 28 Mar. 2007

  
• 24aPS-129 Localization of cell-free synthesized membrane protein in phase-separated giant liposome membrane.

  Nomura M. Shin-ichiro; Akiyoshi Kazunari

  Meeting Abstracts of the Physical Society of Japan, 2007

  
• Amylose engineering: Design of nanogel particles with molecular recognition

  秋吉 一成

  Cosmetology, 2007

  
• Enzyme-responsive molecular assembly system with amylose-primer surfactants

  Nobuyuki Morimoto; Naruhito Ogino; Tadashi Narita; Shinichi Kitamura; Kazunari Akiyoshi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jan. 2007

  
• シャペロン機能工学によるタンパク質の再生・集積制御 (特集:化学が拓く新しいナノバイオ研究)

  秋吉 一成

  現代化学, Nov. 2006

  
• POLY 421-Nanogel artificial chaperone: Refolding and cell-free protein synthesis of GFP

  Wakiko Asayama; Yuta Nomura; Shin-ichi Sawada; Nobuyuki Morimoto; Kazunari Akiyoshi

  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Sep. 2006

  
• 細胞機能をどこまで組み立てられるか? セルサイズリポソーム工学から人工細胞モデルヘ

  野村 M; 慎一郎; 秋吉 一成

  化学と工業, 01 Aug. 2006

  
• Nanogel engineered designs for polymeric drug delivery

  Nobuyuki Morimoto; Shin-ichiro M. Nomura; Naomi Miyazawa; Kazunari Akiyoshi

  POLYMERIC DRUG DELIVERY II: POLYMERIC MATRICES AND DRUG PARTICLE ENGINEERING, 2006

  
• ナノゲル架橋ゲルの設計と人工分子シャペロン機能

  森本 展行; 秋吉 一成

  高分子加工, Nov. 2005

  
• 新しい学生を迎えて

  秋吉 一成

  バイオサイエンスとインダストリー = Bioscience & industry, 01 Jun. 2005

  
• リポソームシャペロン工学による新規DDSの開発

  秋吉 一成

  Drug delivery system, 10 May 2005

  
• Organic Chemistry and Polymer Chemistry : Challenge to Complex System

  AKIYOSHI Kazunari

  Kobunshi, 01 Apr. 2005

  
• 生体システムから学ぶバイオマテリアル創製 (特集 ここまで進んだナノテクの世界) -- (未来を創るナノテクノロジー)

  秋吉 一成

  化学, Jan. 2005

  
• ナノゲルによる人工分子シャペロンの開発 (特集 大きな可能性を秘めた研究開発)

  秋吉 一成; 野村 雄太

  ケミカルエンジニヤリング, Apr. 2004

  
• 自己組織化ナノゲルとナノゲルエンジニアリング

  秋吉 一成

  未来材料, Feb. 2004

  
• 分子シャペロンとナノゲル工学

  秋吉 一成

  Drug delivery system, 10 May 2003

  
• Spontaneous Formation of Giant Liposome Network

  Nomura S.-i.M.; Motoike I.N.; Akiyoshi K.

  Seibutsu Butsuri, 2003

  
• Molecular chaperone as functional nanocarrier of protein

  AKIYOSHI Kazunari; NOMURA Yuta

  Drug Delivery System, 10 Nov. 2002

  
• 神経細胞の「形」とガングリオシド

  野村 M. 慎一郎; 板谷 綾子; 小野 直亮; 吉川 研一; 秋吉 一成

  形の科学会誌 = Bulletin of the Society for Science on Form, 01 Jun. 2002

  
• Interaction between Proteins and Self-Assembled Nanoparticles of Hydrophobized Pullulan with Insulin-Host-Guest Interacton in Macromolecules

  AKIYOSHI Kazunari; KOBAYASHI Seiichi; SUNAMOTO Junzo

  KOBUNSHI RONBUNSHU, 25 Apr. 2001

  
• 自己組織化多糖ナノゲル微粒子の設計と機能 (糖鎖分子の設計と生理機能) -- (糖鎖を有する複合分子の設計・合成・機能)

  秋吉 一成

  季刊化学総説, 2001

  
• Self-assembly and Functions of Hydrophobized Polysaccharides

  AKIYOSHI Kazunari

  Journal of Japan Oil Chemists' Society, 20 May 2000

  
• 疎水化高分子の自己会合体とその機能 (特集 コロイド溶液系の物理と化学)

  秋吉 一成

  表面, Jan. 1999

  
• Gelation of Hydrophobized Pullulan

  AKIYOSHI Kazunari; KURODA Kenichi; SUNAMOTO Junzo

  KOBUNSHI RONBUNSHU, 25 Dec. 1998

  
• Biosimulation by Liposome

  AKIYOSHI Kazunari

  化学と工業 = Chemistry and chemical industry, Jul. 1998

  
• Self-assembly of Hydrophobized Polysaccharide: Formation and Function of Hydrogel Nanoparticle

  AKIYOSHI Kazunari

  Kobunshi, 01 Aug. 1996

  
• Characteristics of hydrogel nanoparticle of amphiphilic polysaccharides : Complexation with globular proteins and their stabilization

  AKIYOSHI Kazunari; SUNAMOTO Junzo

  Seibutsu Butsuri, 25 Sep. 1995

  
• Stabilization of Insulin upon Supramolecular Complexation with Hydrophobized Polysaccharide Nanoparticle

  AKIYOSHI Kazunari; NISHIKAWA Takehiro; SHICHIBE Syozo; SUNAMOTO Junzo

  Chemistry letters, 05 Aug. 1995

  
• Thermodynamic Characterization of Interaction between Self-Aggregates of Cholesterol-bearing Pullulan and Bovine Serum Albumin

  MITSUI Yoshikazu; KODAMA Michiko; NISHIKAWA Takehiro; AKIYOSHI Kazunari; SUNAMOTO Junzo

  Netsu Sokutei, 31 Jul. 1995

  
• Artificial Cell Wall for Plant Protoplast. Coating of Plasma Membrane with Hydrophobized Polysaccharides

  GUO Ze-Jian; KALLUS Stefan; AKIYOSHI Kazunari; SUNAMOTO Junzo

  Chemistry letters, 05 Jun. 1995

  
• O/W-Emulsion as Formed by Cholesterol-Bearing Pullulan

  YAMAGUCHI Shigehiko; FUKUI Hiroki; AKIYOSHI Kazunari; SATO Toshinori; SUNAMOTO Junzo

  NIPPON KAGAKU KAISHI, 10 Feb. 1992

  
• バイオサイエンスにおけるリポソ-ムの役割

  砂本 順三; 秋吉 一成; 佐藤 智典

  バイオサイエンスとインダストリ-, May 1989

  
• 糖鎖の細胞認識機能を利用した生体適合性材料の開発 (1988年の化学-4-)

  秋吉 一成; 砂本 順三

  化学, Apr. 1988

  
• TEM Observation of Hybrid Layer formed by a New Thin Bonding Agent

  SAIMI Yasukazu; OTSUKI Haruka; WATANABE Akihiko; AKIYOSHI Kazunari

  日本歯科保存学雑誌, 06 May 2003

  

Books and Other Publications

• 医用工学ハンドブック

  佐久間, 一郎; 秋吉, 一成; 津本, 浩平

  エヌ・ティー・エス, Feb. 2022

  Find Kyoto University's collection of books :

  
• 糖鎖の新機能開発・応用ハンドブック : 創薬・医療から食品開発まで

  津本, 浩平; 加藤, 晃一; 秋吉, 一成; 鷹羽, 武史; 深瀬, 浩一; 古川, 鋼一

  エヌ・ティー・エス, Aug. 2015

  Find Kyoto University's collection of books :

  
• 先端バイオマテリアルハンドブック

  秋吉, 一成; 石原, 一彦( 工学); 山岡, 哲ニ

  エヌ・ティー・エス, Jun. 2012

  Find Kyoto University's collection of books :

  
• 次世代医療のための高分子材料工学

  秋吉, 一成; 岸田, 晶夫

  シーエムシー出版, Sep. 2008

  Find Kyoto University's collection of books :

  
• リポソーム応用の新展開 : 人工細胞の開発に向けて

  秋吉, 一成; 辻井, 薫; 奥, 直人; 久保井, 亮一; 宝谷, 紘一

  エヌ・ティー・エス, Jun. 2005

  Find Kyoto University's collection of books :

  
• 両親媒性高分子によるナノ組織体の構築

  秋吉, 一成

  [秋吉一成], 1998

  

Industrial Property Rights

• 特許第6813192号, 特願2017-540922, 両親媒性ブロック共重合体、分子集合体及びその製造方法並びにタンパク質の内包剤

  秋吉 一成; 西村 智貴

  
• 特許第6763545号, WO2016-167367, JP2016062184, 標的化両親媒性ナノキャリア及びその製造方法

  秋吉 一成; 安藤 満; 三浦 理紗子; 澤田 晋一; 珠玖 洋; 赤堀 泰

  
• 特開2020-019754, 特願2018-147175, ウシ乳房炎に対する粘膜ワクチン組成物

  林 智人; 菊 佳男; 長澤 裕哉; 秋吉 一成; 澤田 晋一; 麻生 久; 野地 智法

  
• 特開2019-154283, 特願2018-043297, 多能性幹細胞を骨芽細胞へと分化誘導することにより得られうる細胞集団から骨芽細胞を検出する方法、及びその方法のために用いられるキット

  秋吉 一成; 下田 麻子

  
• 特許第6558699号, WO2015-050158, JP2014076286, 抗原提示を促進するエピトープ間配列を含むT細胞誘導ワクチン

  珠玖 洋; 原田 直純; 村岡 大輔; 秋吉 一成

  
• 特許第6320781号, 特開2015-147860, 特願2014-021082, フェロシアン化物粒子-多糖類複合体

  関根 由莉奈; 深澤 裕; 秋吉 一成; 佐々木 善浩; 澤田 晋一

  
• 特許第6310720号, 特開2015-151375, 特願2014-027205, 肺炎球菌経鼻ワクチン

  幸 義和; 清野 宏; 秋吉 一成; 澤田 晋一

  
• 特許第6272765号, WO2014-054588, JP2013076577, ナノゲル/エキソソーム複合体とDDS

  秋吉 一成; 澤田 晋一; 珠玖 洋; 原田 直純; 瀬尾 尚宏

  
• 特開2017-160199, 特願2017-043500, カチオン性グルカンナノスフェア、複合体、核酸導入剤及びがん治療剤

  秋吉 一成; 竹田 茂生; 澤田 晋一; 佐々木 善浩

  
• WO2017-138557, JP2017004552, 免疫チェックポイント阻害剤抵抗性腫瘍に対するT細胞輸注療法の前処置薬

  珠玖 洋; 原田 直純; 村岡 大輔; 秋吉 一成

  
• 特許第6137894号, 特開2014-185090, 特願2013-060148, リポソーム-エキソソームハイブリッドベシクル及びその調製法

  秋吉 一成; 佐藤 祐子; 澤田 晋一

  
• 特許第6082633号, 特開2014-185127, 特願2013-062915, 多糖ナノゲルおよびその製造方法、ならびにそれを用いた創傷治癒剤

  河野 麻実子; 北村 進一; 庄條 愛子; 秋吉 一成; 澤田 晋一

  
• 特許第6041314号, WO2013-031882, JP2012071979, がん治療用ワクチン製剤

  珠玖 洋; 原田 直純; 村岡 大輔; 秋吉 一成

  
• WO2016-152786, JP2016058721, 細胞傷害性T細胞放出エキソソームによる癌間質間葉系細胞を標的とした腫瘍増殖及び転移抑制に係る治療薬

  珠玖 洋; 瀬尾 尚宏; 秋吉 一成; 原田 直純; 百瀬 文康

  
• 特開2016-088862, 特願2014-222812, 人工分子シャペロン、カラム及びタンパク質のリフォールディング方法

  秋吉 一成; 竹田 茂生; 澤田 晋一; 佐々木 善浩

  
• WO2014-157606, JP2014059082, 架橋された疎水化多糖ナノゲル粒子とその製造方法

  秋吉 一成; 田原 義朗; 向井 貞篤; 澤田 晋一

  
• 特開2014-101273, 特願2011-043237, 脂質構造体の製造方法

  佐々木 善浩; 秋吉 一成

  
• 特許第5542687号, WO2010-053140, JP2009068933, ヒアルロン酸誘導体、およびその医薬組成物

  秋吉 一成; 中井 貴士; 平倉 泰; 下房地 剛

  
• 特許第5443976号, WO2008-136536, JP2008058593, 化学架橋ヒアルロン酸誘導体を含むハイブリッドゲルおよびそれを用いた医薬組成物

  秋吉 一成; 森本 展行; 平倉 泰; 下房地 剛

  
• 特許第5439650号, WO2006-049032, JP2005019536, ナノゲル-アパタイト複合体の調製

  秋吉 一成; 菅原 彩絵

  
• 特許第5344558号, 特開2010-105968, 特願2008-281065, カチオン性ナノゲルを用いる粘膜ワクチン

  秋吉 一成; 清野 宏; 幸 義和; 野地 智法

  
• 特許第5057362号, WO2006-049307, JP2005020486, リポソーム及びこれを用いた細胞に対する物質注入方法

  森田 育男; 秋吉 一成; 野村 慎一郎

  
• 特許第5044777号, 特開2007-301029, 特願2006-130635, 細胞固定化基材被覆膜用材料

  岩崎 泰彦; 秋吉 一成; 篠原 由里香

  
• 特許第4843797号, WO2007-083643, JP2007050555, 骨形成促進物質とナノゲルを含有する骨形成用生体材料

  秋吉 一成; 野田 政樹

  
• 特許第4774506号, 特開2005-306748, 特願2004-123063, 機能性酵素重合アミロース誘導体合成のための新規プライマー

  秋吉 一成; 森本 展行

  
• 特許第4727941号, 特開2005-255969, 特願2004-113646, 生分解性重合体の製造方法および用途

  岩崎 泰彦; 秋吉 一成; 石原 一彦

  
• 特許第4727938号, 特開2005-239989, 特願2004-081431, リビングラジカル重合開始基を持つポリリン酸の製造方法および用途

  岩崎 泰彦; 秋吉 一成; 石原 一彦

  
• 特許第4599550号, 特開2005-298644, 特願2004-115613, ナノゲル工学によるハイブリッドゲルの調製とバイオマテリアル応用

  秋吉 一成; 森本 展行; 岩崎 泰彦

  
• 特許第4550555号, 特開2006-143808, 特願2004-333223, 量子ドット(Qdot)-ナノゲル複合体の調製

  秋吉 一成; 平野 隆; 長谷川 麗

  
• 特許第4405769号, 特開2005-080579, 特願2003-316748, 動物細胞固定化材及び動物細胞固定化方法

  岩崎 泰彦; 秋吉 一成; 田畑 絵美; 榊 秀次郎

  
• 特開2009-149526, 特願2007-326099, サイトカイン-ナノゲル複合体を含む皮下注射又は筋肉内注射徐放製剤

  秋吉 一成; 松田 修; 岸田 綱郎; 清水 健

  
• 特許第4100499号, 特開2003-342292, 特願2002-147147, 蛋白質の制御方法

  秋吉 一成

  
• 特開2007-252304, 特願2006-082647, ナノゲルを用いたタンパク質の細胞内導入法

  秋吉 一成; 菖蒲 弘人

  
• 特許第3996295号, 特開2000-282013, 特願平11-092402, 帯電防止剤および帯電防止方法

  矢野 嘉宏; 島田 邦男; 林 昭男; 細谷 竜三; 砂本 順三; 秋吉 一成

  
• 特開2005-225796, 特願2004-035471, リポソームを用いたタンパク質の製造方法

  秋吉 一成; 野村 慎一郎; 朝田 晃一

  
• WO2005-072753, JP2005001231, 多血小板血漿からなる組成物

  角田 愛美; 春日井 昇平; 秋吉 一成; 岩崎 泰彦

  
• 特許第3636073号, WO2000-057841, JP2000002044, 多糖類-ステロール誘導体含有化粧料

  砂本 順三; 島田 邦男; 林 昭男; 細谷 竜三; 矢野 嘉宏; 秋吉 一成

  
• WO2004-012750, JP2003009795, 血小板多血漿の調製方法

  角田 愛美; 春日井 昇平; 秋吉 一成; 岩崎 泰彦

  
• 特開2003-310295, 特願2002-128899, 蛋白質の製造方法

  秋吉 一成; 西川 茂道

  
• 特許第3416951号, WO2000-012564, JP1999001683, 高純度疎水性基含有多糖類およびその製造方法

  砂本 順三; 秋吉 一成; 細谷 竜三; 福井 洋樹; 林 昭男

  
• 特開平7-097333, 特願平5-326635, 超分子構造型集合体

  砂本 順三; 秋吉 一成; 岩佐 進; 佐藤 純

  
• 特開平5-139967, 特願平3-045694, 制癌剤

  砂本 順三; 秋吉 一成; 佐藤 智典; 福井 洋樹; 山口 茂彦

  

External funds: Kakenhi

• Differential regulation of TGFR family signaling and bone and cartilage tissue regeneration

  Grant-in-Aid for Scientific Research (B)

  Basic Section 56020:Orthopedics-related

  Kyoto Prefectural University of Medicine

  松田 修

  From 01 Apr. 2021, To 31 Mar. 2024, Granted

  再生医療;骨軟骨疾患;ダイレクト・リプログラミング;ダイレクトリプログラミング;サイトカイン;ケミカル・ダイレクト・リプログラミング

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H03058/
• Development of a revolutionary bone anabolic reagent by optimizing the RANKL reverse signaling to stimulate bone formation.

  Grant-in-Aid for Scientific Research (A)

  Medium-sized Section 57:Oral science and related fields

  Tokyo Medical and Dental University

  青木 和広

  From 01 Apr. 2019, To 31 Mar. 2023, Granted

  骨形成促進薬;骨芽細胞;RANKL逆シグナル;プロテオリポソーム;ペプチド創薬;AFM;抗体改編技術;RANKL結合ペプチド;RANK搭載膜小胞;原子間力顕微鏡;膜小胞;プロテオリポソーム技術;骨形成促進剤開発;人工エクソソーム;骨形成活性

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H01068/
• Development of nanogel hybrid materials for medical application

  Grant-in-Aid for Scientific Research (S)

  Kyoto University

  Kazunari Akiyoshi

  From 31 May 2016, To 31 Mar. 2021, Project Closed

  ナノゲル;ドラッグデリバリーシステム;がん治療;再生医療;バイオマテリアル;DDS;がん免疫療法;糖鎖ポリマー;がんワクチン;核酸デリバリー;タンパク質デリバリー;バオマテリアル;生体材料

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H06313/
• Development of a molecule control in allergic rhinitis by a delivery of an artificial transcription factor

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto Prefectural University of Medicine

  Masaharu Shin-Ya

  From 01 Apr. 2015, To 31 Mar. 2016, Project Closed

  アレルギー

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K15622/
• Analysis on the possibility of various tissue regeneration with the Nanogel possesing a molecular chaperone function

  Grant-in-Aid for Research Activity Start-up

  Tokyo Medical and Dental University

  Takayuki Miyahara

  From 29 Aug. 2014, To 31 Mar. 2016, Project Closed

  骨再生;GBR;Nanogel;membrane;collagen;nano gel;再生医療;メンブレン;軟組織再生;硬組織再生;ドラッグデリバリーシステム(DDS);ナノキャリアー;分子シャペロン機能;骨組織再生;神経組織再生;Guided Bone Regeneration;国際情報交換

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26893073/
• Regenerative therapy for metabolic diseases based on chemical direct reprogramming

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto Prefectural University of Medicine

  Mazda OSAM

  From 01 Apr. 2014, To 31 Mar. 2015, Project Closed

  糖脂質代謝

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26670452/
• Development of novel technology for prevention of mastitis using nanotechnology

  Grant-in-Aid for Challenging Exploratory Research

  Tohoku University

  Tomonori Nochi

  From 01 Apr. 2014, To 31 Mar. 2017, Project Closed

  黄色ブドウ球菌;乳房炎;抗体;増殖阻害;in vitro;ウシポリクローナル抗体;ナノテクノロジー

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26660245/
• Development of new therapeutic strategy for the craniosynostosis patients

  Grant-in-Aid for Scientific Research (B)

  Tokyo Medical and Dental University

  Keiji MORIYAMA

  From 01 Apr. 2011, To 31 Mar. 2014, Project Closed

  歯学;頭蓋冠縫合部早期癒合症;ナノサイエンス;アペール症候群;FGFR2;可溶型受容体;Apert症候群;先天異常;骨芽細胞分化

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390471/
• Development of cancer-controlling vector conversion techniques using nano-DDS

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Kyoto University

  Kazunari AKIYOSHI

  From 01 Apr. 2010, To 31 Mar. 2015, Project Closed

  ドラッグデリバリーシステム;がん治療;ナノゲル;ワクチン;エクソソーム;siRNA;腫瘍微小環境;細胞特異性;RGDペプチド;抗体;サイトカイン;タンパク質デリバリー;核酸デリバリー;エンドサイトーシス;遺伝子導入;シャペロン機能

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-22114009/
• Infection/inflammation-assisted acceleration of the carcinogenic spiral and its alteration though vector conversion of the host response to tumors

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  The University of Tokyo

  Masanori HATAKEYAMA

  From 01 Apr. 2010, To 31 Mar. 2016, Project Closed

  癌;感染;炎症・免疫;発がんスパイラル;がん;感染症;感染がん;炎症;免疫;ドラッグデリバリー;細菌;シグナル伝達

  https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-22114001/
• Mechanism for maintenance of homeostasis of several functions by connexin 43

  Grant-in-Aid for Scientific Research (B)

  Tokyo Medical and Dental University

  Ikuo MORITA

  From 01 Apr. 2008, To 31 Mar. 2011, Project Closed

  コネキシン;ギャップ結合;薬物導入法;annular gap;細胞分化;リポソーム;DDS;ナノサイエンス;PI3キナーゼ;AKT;細胞マニピュレーション

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390470/
• Nano DDS-mediated cytokine delivery and control of allergic responses.

  Grant-in-Aid for Scientific Research (B)

  Kyoto Prefectural University of Medicine

  Osam MAZDA

  From 01 Apr. 2008, To 31 Mar. 2011, Project Closed

  アレルギー;ぜんそく;ナノ材料;アレルギー・ぜんそく;内科;癌

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390281/
• Development ofnew nanogel-based drug delivery systems

  Grant-in-Aid for Scientific Research (A)

  Kyoto University;Tokyo Medical and Dental University

  Kazunari AKIYOSHI

  From 01 Apr. 2008, To 31 Mar. 2013, Project Closed

  ナノゲル;ヒドロゲル;タンパク質;ドラッグデリバリー;細胞機能;多糖;タンパク質デリバリー;核酸デリバリー;反応性ナノゲル;骨形成;ビタミンB6;リポソーム;Schiff塩基;ドラッグデリバリーシステム;再生医療用足場材料;ナノゲル架橋微粒子;プロスタグランジンE1;骨再生;アパタイト;有機-無機ハイブリッド

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20240047/
• Development of nanocarrier for cancer immunotherapy

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Tokyo Medical and Dental University

  Kazunari AKIYOSHI

  From 01 Apr. 2008, To 31 Mar. 2010, Project Closed

  癌免疫;サイトカイン;ナノゲル;遺伝子デリバリー;分子シャペロン;カチオン性多糖;タンパク質ワクチン;トランスフェクション;サイトカン;潰伝子デリバリー

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20011002/
• A novel drug delivery system via inhalation of nanoparticles

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Takuji FUJINAGA

  From 01 Apr. 2007, To 31 Mar. 2009, Project Closed

  ナノ粒子;DDS;肺移植;心臓死ドナー;心停止ドナー;吸入

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19591623/
• Physico-chemical approach on the construction of functional denovo cell

  Grant-in-Aid for Creative Scientific Research

  Kyoto University

  Kenichi YOSHIKAWA

  From 01 Apr. 2006, To 31 Mar. 2011, Project Closed

  リポソーム;人工細胞モデル;化学物理;物性基礎論;生物物理;自己組織化;生命物理;ゲノムDNA;リポソ-ム;メゾスコピック系;メソスコピック系

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18GS0421/
• 新規ペプチドを用いたナノゲルエンジニアリングによる口腔乾燥の標的治療

  Grant-in-Aid for Exploratory Research

  The Nippon Dental University

  松野 智宣

  From 01 Apr. 2006, To 31 Mar. 2008, Project Closed

  口腔乾燥(ドライマウス);ナノテクノロジー;ドラッグデリバリーシステム;ペプチド;ナノゲル;標的治療;再生医療;唾液腺分泌機能

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18659608/
• 膜タンパク質機能を組込んだ人工細胞の創製と応用

  Grant-in-Aid for Scientific Research on Priority Areas

  Science and Engineering

  Tokyo Medical and Dental University

  秋吉 一成

  From 01 Apr. 2006, To 31 Mar. 2008, Project Closed

  膜タンパク質;人工細胞;リポソーム;無細胞タンパク質合成;プロテオリポソーム;シャペロン;コネキシン;ホスホリラーゼ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18048013/
• 癌免疫治療のための新規ナノゲルキャリアの開発

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Tokyo Medical and Dental University

  秋吉 一成

  From 01 Apr. 2006, To 31 Mar. 2008, Project Closed

  癌免疫;ナノゲル;インターロイキン12;DDS;癌抗原;癌タンパク質ワクチン;癌免疫治療;サイトカイン;IL12

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18011002/
• ナノキャリアー分子コンジュゲートを用いた癌の免疫サイトカイン療法

  Grant-in-Aid for Exploratory Research

  Kyoto Prefectural University of Medicine

  松田 修

  From 01 Apr. 2005, To 31 Mar. 2007, Project Closed

  ナノ材料;ナノバイオ;癌;免疫学;サイトカイン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17659394/
• 非天然膜糖鎖認識を介した新しい薬物輸送システムの開拓

  Grant-in-Aid for Exploratory Research

  Tokyo Medical and Dental University

  岩崎 泰彦

  From 01 Apr. 2005, To 31 Mar. 2007, Project Closed

  両親媒性ポリマー;ナノ粒子;標的指向型薬物キャリア;ポリホスフェート;リビングラジカル重合;生分解性ポリマー;ホスホリルコリンポリマー;生体適合性

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17650132/
• Design of hybrid hydrogels by nanogel engineering for biomaterials

  Grant-in-Aid for Scientific Research (B)

  Tokyo Medical and Dental University

  Kazunari AKIYOSHI

  From 01 Apr. 2005, To 31 Mar. 2007, Project Closed

  ナノゲル;ヒドロゲル;疎水化多糖;量子ドット;アパタイト;分子シャペロン;生分解性;リポソーム, nanogels;hydrogel;hydrophobized polysacchardes;quantum dot;apatite;molecular chaperone

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17300147/
• Analysis of pathology based on four-dimensional analysis of intracellular communication through gap junction and their development for therapy

  Grant-in-Aid for Scientific Research (A)

  Tokyo Medical and Dental University

  Ikuo MORITA

  From 01 Apr. 2005, To 31 Mar. 2008, Project Closed

  コネキシン;ギャップ結合;細胞分化;細胞密度;薬物導入法;リポソーム;PI3キナーゼ;発現調節;mRNA安定性;骨代謝;DDS;細胞増殖, Connexin;Gap Junction;Differentiation;Cell Density;Expression;mRNA Stability;PI3 kinase

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17209058/
• 分子シャペロン機能を有するナノゲルキャリアによる新規DDSの開発

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Tokyo Medical and Dental University

  秋吉 一成

  From 01 Apr. 2005, To 31 Mar. 2006, Project Closed

  癌免疫療法;サイトカイン;インターロイキン12(IL12);ナノゲル;分子シャペロン機能;ドラッグデリバリーシステム;腫瘍抑制;徐放

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17012008/
• 機能性微粒子に制御させる次世代抗癌剤のナノアッセンブリ的合成と選択的デリバリー

  Grant-in-Aid for Exploratory Research

  The University of Tokyo

  江里口 正純

  From 01 Apr. 2004, To 31 Mar. 2006, Project Closed

  Diplatin;Pullulan;Nanogel;Gastric Cancer;ナノアッセンブリ;Pullula;Nano-assembly construction

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16659352/
• ニューロンインスパイアードナノチューブ・リポソームネットワークの設計と機能

  Grant-in-Aid for Exploratory Research

  Tokyo Medical and Dental University

  秋吉 一成

  From 01 Apr. 2003, To 31 Mar. 2005, Project Closed

  コレステロール;リポソーム;脂質ナノチューブ;ネットワーク;細胞サイズリポソーム;細胞モデル;神経細胞;蛍光顕微鏡;ガングリオシド;チューブ;巨大ベシクル

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15650090/
• Design of bio-nanosystem by dynamic control of nanoorganization

  Grant-in-Aid for Scientific Research (B)

  Tokyo Medical and Dental University

  Kazunari AKIYOSHI

  From 01 Apr. 2003, To 31 Mar. 2005, Project Closed

  ナノゲル;会合性高分子;自己組織化;疎水化多糖;刺激応答性;人工分子シャペロン;タンパク質フォールディング;分子シャペロン;細胞外タンパク質合成, Nanogel;Associated polymer;Self-assembly;Hydrophobized polysaccharides;Stimuli-responsive;Artificial molecular chaperone;Protein folding

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15300158/
• シャペロニング機能を有する分子シンクロシステムの構築

  Grant-in-Aid for Scientific Research on Priority Areas

  Science and Engineering

  Tokyo Medical and Dental University;Kyoto University

  秋吉 一成

  From 01 Apr. 2002, To 31 Mar. 2003, Project Closed

  分子シャペロン;分子シンクロ;人工分子シャペロン;ナノゲル;疎水化多糖;スピロピラン;タンパク質;リフォールディング;シクロデキストリン;タンパク質のリフォールディング;DNAの二重鎖形成

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13022233/
• Simulation of Cell Recognition As Studied by Using Macrocyclic Sacchraide Clusters

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Yasuhiro AOYAMA

  From 01 Apr. 2001, To 31 Mar. 2004, Project Closed

  遺伝子;遺伝子運搬;人工グリコウイルス;糖クラスター;ガラクトース;細胞認識;プロテオグリカン;細胞接着;人工ウイルス;肝細胞;エンドサイトーシス;量子ドット;コンドロイチン硫酸;遺伝子診断;ナノパーティクル;水素結合;核酸;遺伝子導入;細胞;トランスフェクション;薬物運搬;ルシフェラーゼ;受容体, gene;gene delivery;artificial glycovirus;glycocluster;galactose;cell recognition;proteoglycan;cell adhesion

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13490021/
• Translational Research of A Novel Hydrophobized Polysacchaide/Oncoprotein Complex Vaccines for Cancer

  Grant-in-Aid for Scientific Research (A)

  Mie University

  Hiroshi SHIKU

  From 01 Apr. 2001, To 31 Mar. 2004, Project Closed

  癌遺伝子;キラーT細胞;ヘルパーT細胞;多価性がんワクチン;HER2;癌ワクチン;ペプチド;CTLエピトープ;ヘルパーエピトープ, oncogene;killer T cells;helper T cells;polyvalent cancer vaccine;HER2

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13357009/
• Developing and clinical application of a highly reliable dentin-bonding system.

  Grant-in-Aid for Scientific Research (B)

  Tokyo Medical and Dental University

  Akihiko WATANABE

  From 01 Apr. 2000, To 31 Mar. 2003, Project Closed

  脱灰象牙質;樹脂含浸層;ウェットボンディング法;接着メカニズム;青色レーザー;走査電子顕微鏡;透過電子顕微鏡;走査プローブ顕微鏡;青色レーザーパタイト;樹脂含浸象牙質;ウエットボンディング;エチレンジアミン四酢酸塩;光硬化型レジン;AFM;ミニダンベル型引張試験;アセトンプライマー;接着促進モノマー;光重合型レジン, Demineralized dentin;Hybrid layer;Wet bonding;Bonding mechanism;Blue laser;Scanning electron microscope;Scanning probe microscope;Transmission electron microscope

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12470404/
• 糖分子鎖集合体

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  Nagoya University

  小林 一清

  From 01 Apr. 1999, To 31 Mar. 2000, Project Closed

  糖鎖;高分子;分子認識;集合体;生体機能材料

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09240105/
• Cell surface engineering

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  Kyoto University

  Atsuo TANAKA

  From 01 Apr. 1998, To 31 Mar. 2002, Project Closed

  細胞表層;武装酵母;バイオマス;抗ニワトリ卵白リゾチーム;増殖因子;キメラレセプター;糖脂質;リポソーム;細胞表層工学;酵母;アーミング;アンカリング;ペプチド;抗体-受容体キメラ;シグナル伝達;分子ターゲティング;リパーゼ;キメラ受容体;抗体;エリスロポエチン;シアル酸;新機能細胞;抗体可変領域;c-Kit;ガングリオシド, Cell surface;Arming yeast;Biomass;Anti-hen egg lysozyme;growth factor;Chimeric receptor;cell-surface saccharides;lipospme

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10145107/
• Super-Biosystem Constructed by Cognitive Multidimensional Glyco-Molecules

  Grant-in-Aid for Scientific Research on Priority Areas

  Teikyo University of Science and Technology;The University of Tokyo

  Toshiyuki URYU

  From 01 Apr. 1997, To 31 Mar. 2001, Project Closed

  糖鎖合成;分子集合体;生命分子制御;細胞機能制御;糖鎖認識;糖質高分子;機能性多糖;生理機能糖鎖;糖質自動合成システム;共重合型糖鎖高分子;コレステロール置換プルラン;抗エイズウイルス活性;エイズ薬デリバリー;ガラクトース転移酵素;糖タンパク質;硫酸化グルコース担持ポリマー;糖鎖自動合成法;ポリシアロガングリオシド;人工複合糖鎖ポリマー;両親媒性多糖;抗エイズウイルス作用;高分子コンジュゲート医薬;個体発生;植物主体防御;オリゴ糖;糖脂質;ピロテオグリカン;生理活性;薬理活性;ドラッグデリバリーシステム, Saccharide chain synthesis;Aggregate of molecules;Control of biomolecules;Control of cell functions;Saccharide chain recognition;Glycopolymer;Functional polysaccharide;Biofunctional saccharide chain

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09240102/
• 両親媒性高分子間の会合制御による新規ナノ組織体の構築と機能

  Grant-in-Aid for Scientific Research on Priority Areas

  Kyoto University

  秋吉 一成

  From 01 Apr. 1997, To 31 Mar. 1998, Project Closed

  両親媒性高分子;ナノ組織体;疎水化高分子;自己組織化;多糖;蛋白質

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09232235/
• Nano-Organized Systems of Amphiphilic Polymers

  Grant-in-Aid for Scientific Research (B)

  KYOTO UNIVERSITY

  Kazunori AKIYOSHI

  From 01 Apr. 1996, To 31 Mar. 1998, Project Closed

  両親媒性高分子;ナノ組織体;多糖;ポリアミノ酸;ナノ微粒子;ヒドロゲル;ゲル;疎水化高分子;コレステロール;ヘリックス, Amphiphilic Polymer;Self-Organized system;Polysaccharide;naroparticle;Hydrogel;Hydrophobized Polymer;Protein;Association

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08455440/
• 両親媒性糖鎖の超分子形成と機能

  Grant-in-Aid for Scientific Research on Priority Areas

  Kyoto University

  秋吉 一成

  From 01 Apr. 1996, To 31 Mar. 1997, Project Closed

  糖;シアル酸;ガングリオシド;T-細胞;共焦点レーザー蛍光顕微鏡;リポソーム;細胞増殖;脂質

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08219225/
• 疎水化水溶性高分子の自己組織化とその機能

  Grant-in-Aid for General Scientific Research (C)

  Kyoto University

  秋吉 一成

  From 01 Apr. 1995, To 31 Mar. 1996, Project Closed

  疎水化水溶性高分子;自己組織体;ヒドロゲル;多糖;プルラン;コレステロール;ナノパーティクル;超分子

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07651084/
• Control of Cell Functions by Functioralized Liposomes

  Grant-in-Aid for Scientific Research (A)

  KYOTO UNIVERSITY

  Junzo SUNAMOTO

  From 01 Apr. 1995, To 31 Mar. 1999, Project Closed

  膜タンパク質;リポソーム;カドヘリン;細胞間接着;酸素電極;酸素消費;ガングリオシド;細胞刺激;膜タンパク質移行;赤血球細胞膜;細胞内カルシウム;T細胞活性化;膜タンパク質再構成;E-カドヘリン;F9細胞;シアル酸;T細胞刺激;細胞内カルシウム濃度, Membrane protein;Liposome;cadherin;cell-cell adhesion;O_2-electrode;O_2 uptake;Ganglioside;cell-stimulation

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07405044/
• 両親媒性糖鎖の超分子形成と機能

  Grant-in-Aid for Scientific Research on Priority Areas

  Kyoto University

  秋吉 一成

  From 01 Apr. 1995, To 31 Mar. 1996, Project Closed

  超分子;糖脂質;ガングリオシド;T-細胞;リポソーム;両親媒性高分子;疎水化多糖;ヒドロゲル

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07229227/
• 両親媒性高分子とタンパク質との自己組織的複合体形成とその機能

  Grant-in-Aid for General Scientific Research (C)

  Kyoto University

  秋吉 一成

  From 01 Apr. 1994, To 31 Mar. 1995, Project Closed

  両親媒性高分子;タンパク質;自己組織化;ヒドロゲル;ナノパーティクル;熱安定性;多糖;コレステロール

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06651027/
• 両親媒性多糖類の超分子形成と機能

  Grant-in-Aid for Scientific Research on Priority Areas

  Kyoto University

  秋吉 一成

  From 01 Apr. 1994, To 31 Mar. 1995, Project Closed

  両親媒性;多糖;超分子;ヒドロゲル;ナノパーティクル;コレステロール;プルラン;糖脂質

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06240229/
• 新規両親媒性多糖誘導体の合成と機能

  Grant-in-Aid for Encouragement of Young Scientists (A)

  Kyoto University

  秋吉 一成

  From 01 Apr. 1993, To 31 Mar. 1994, Project Closed

  天然多糖類;両親媒性;プルラン;コレステロール基;ポリエチレングリコール;高分子集合体;ナノパーティクル;ヒドロゲル

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05750784/
• Characterization and Application of Polysaccharide-coated O/W emulsion

  Grant-in-Aid for Developmental Scientific Research (B)

  KYOTO UNIVERSITY

  Junzo SUNAMOTO

  From 01 Apr. 1993, To 31 Mar. 1996, Project Closed

  天然多糖類;両親媒性;プルラン;コレステロール;O;Wエマルション;制癌剤;α-リレレン酸;ドラッグキャリアー;α-リノレン酸;多糖;両観媒性, Polysaccharide;Amphiphilic;pullulan;cholesterol;O;W emulsion;antitumor Agent;alpha-linolenicacid;Drug Carrier

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05555256/
• 糖鎖ポリマーの合成と機能発現メカニズムに関する研究

  Grant-in-Aid for Co-operative Research (B)

  The University of Tokyo

  瓜生 敏之

  From 01 Apr. 1993, To 31 Mar. 1994, Project Closed

  多糖・オリゴ糖;糖鎖ポリマー;高分子医薬;キチン;キトサン;機能発現;創傷治癒効果;徐放性医薬

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05353010/
• Membrane protein transfer from intact cell to liposome

  Grant-in-Aid for General Scientific Research (B)

  KYOTO UNIVERSITY

  Junzo SUNAMOTO

  From 01 Apr. 1990, To 31 Mar. 1992, Project Closed

  膜タンパク質;リポソーム;人工境界脂質;リポソームワクチン;癌;赤血球;リポソ-ム;リポソ-ムワクチン;膜タンパク再構成リポソ-ム;人工ワクチン, membrane protein;liposome;transfer;liposomal vaccine;cancer cell;boundary lipid;erythrocyte;platelet

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02453099/
• 人工細胞を用いる細胞間情報伝達機構の解明とその医療への応用

  Grant-in-Aid for Scientific Research on Priority Areas

  Kyoto University

  砂本 順三

  From 01 Apr. 1989, To 31 Mar. 1990, Project Closed

  人工細胞;細胞間情報伝達;糖鎖認識;ガングリオシド;人工ワクチン;人工境界脂質

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-01604013/
• 人工細胞を用いる細胞間情報伝達機構の解明とその医療への応用

  Grant-in-Aid for Scientific Research on Priority Areas

  Nagasaki University

  砂本 順三

  From 01 Apr. 1988, To 31 Mar. 1989, Project Closed

  人工細胞;細胞間情報伝達;ドラッグデリバリーシステム;人工ワクチン;人工境界脂質

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-63604581/
• Functional analyses of sugar codes of exosomes and biomedical applications

  Grant-in-Aid for Scientific Research (A)

  Medium-sized Section 90:Biomedical engineering and related fields

  Kyoto University

  秋吉 一成

  From 01 Apr. 2022, To 31 Mar. 2026, Granted

  エクソソーム;糖鎖解析;レクチンマクロアレイ;レクチンマイクロアレイ;糖鎖;レクチンマイクロアレイ解析

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H00585/
• デザイナーマトリックスによる生命現象の理解と制御

  Grant-in-Aid for Transformative Research Areas (A)

  Transformative Research Areas, Section (III)

  Tokyo Medical and Dental University;Nagoya University

  鳴瀧 彩絵

  From 01 Apr. 2023, To 31 Mar. 2028, Granted

  デザイナーマトリックス;ハイドロゲル;粘弾性;ナノゲル

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-23H04934/
• 領域研究「細胞外情報を統御するマルチモーダルECM」の統括と運営

  Grant-in-Aid for Transformative Research Areas (A)

  Transformative Research Areas, Section (III)

  Institute of Physical and Chemical Research

  藤原 裕展

  From 01 Apr. 2023, To 31 Mar. 2028, Granted

  細胞外マトリックス;技術支援;研究資源共有化;若手支援;広報

  https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-23H04927/
• Development of regenerative dental medicine using high functional exosome derived from directly converted mesenchymal stem cells

  Grant-in-Aid for Scientific Research (B)

  Basic Section 57040:Regenerative dentistry and dental engineering-related

  Kyoto Prefectural University of Medicine

  山本 健太

  From 01 Apr. 2024, To 31 Mar. 2028, Granted

  再生医療;ダイレクト・コンヴァージョン;エクソソーム;間葉系幹細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K02627/