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Okubo, Chikako

Center for iPS Cell Research and Application (CiRA) Assistant Professor

Okubo, Chikako
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    Last Updated :2026/09/10

    Basic Information

    Email Address

    • Email Address

      okubo.chikako.7zkyoto-u.ac.jp

    Academic Degree

    • 23 Mar. 2015
      京都大学修士（医科学）
    • 24 Sep. 2021
      京都大学博士（医学）

    Academic Resume (Graduate Schools)

    • 京都大学, 大学院医学研究科博士課程医学専攻, 研究指導認定退学
    • 京都大学, 大学院医学研究科修士課程医科学専攻, 修了
    • 京都大学, 大学院医学研究科博士課程医学専攻, 修了

    Academic Resume (Undergraduate School/Majors)

    • 慶応義塾大学, 環境情報学部情報環境学科, 卒業

    ID,URL

    researchmap URL

    list
      Last Updated :2026/09/10

      Research

      Papers

      • EIF3H Sustains Translational Programs Essential for Proliferation in Human Primed Pluripotency
        Satoshi Suzuki; Chikako Okubo; Michiko Nakamura; Mari Hamao; Qi Fang; Knut Woltjen; Kazutoshi Takahashi
        20 May 2026
      • Comparative benchmarking of CRISPRi and CasRx in standardized pluripotent stem cell platforms reveals context-dependent knockdown performance
        Lu Ni; Takuya Murakami; Satoshi Suzuki; Mari Hamao; Michiko Nakamura; Chikako Okubo; Kazutoshi Takahashi
        14 May 2026
      • EIF3D safeguards the homeostasis of key signaling pathways in human primed pluripotency
        Chikako Okubo; Michiko Nakamura; Masae Sato; Yuichi Shichino; Mari Mito; Yasuhiro Takashima; Shintaro Iwasaki; Kazutoshi Takahashi
        Science Advances, 11 Apr. 2025
      • CD151 expression marks atrial- and ventricular- differentiation from human induced pluripotent stem cells.
        Misato Nakanishi-Koakutsu; Kenji Miki; Yuki Naka; Masako Sasaki; Takayuki Wakimizu; Stephanie C Napier; Chikako Okubo; Megumi Narita; Misato Nishikawa; Reo Hata; Kazuhisa Chonabayashi; Akitsu Hotta; Kenichi Imahashi; Tomoyuki Nishimoto; Yoshinori Yoshida
        Communications biology, 28 Feb. 2024
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      • Selective Translation Orchestrates Key Signaling Pathways in Primed Pluripotency
        Chikako Okubo; Michiko Nakamura; Masae Sato; Yuichi Shichino; Mari Mito; Yasuhiro Takashima; Shintaro Iwasaki; Kazutoshi Takahashi
        bioRxiv, 10 Feb. 2024
      • Am80, a retinoic acid receptor agonist, activates the cardiomyocyte cell cycle and enhances engraftment in the heart.
        Manabu Kasamoto; Shunsuke Funakoshi; Takeshi Hatani; Chikako Okubo; Yohei Nishi; Yuta Tsujisaka; Misato Nishikawa; Megumi Narita; Akira Ohta; Takeshi Kimura; Yoshinori Yoshida
        Stem cell reports, 27 Jun. 2023
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      • Purification of human iPSC-derived cells at large scale using microRNA switch and magnetic-activated cell sorting.
        Yuta Tsujisaka; Takeshi Hatani; Chikako Okubo; Ryo Ito; Azuma Kimura; Megumi Narita; Kazuhisa Chonabayashi; Shunsuke Funakoshi; Antonio Lucena-Cacace; Taro Toyoda; Kenji Osafune; Takeshi Kimura; Hirohide Saito; Yoshinori Yoshida
        Stem cell reports, 12 Jul. 2022
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      • Multi-omics approach reveals posttranscriptionally regulated genes are essential for human pluripotent stem cells.
        Mio Iwasaki; Yuka Kawahara; Chikako Okubo; Tatsuya Yamakawa; Michiko Nakamura; Tsuyoshi Tabata; Yohei Nishi; Megumi Narita; Akira Ohta; Hirohide Saito; Takuya Yamamoto; Masato Nakagawa; Shinya Yamanaka; Kazutoshi Takahashi
        iScience, 20 May 2022
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      • A stress-reduced passaging technique improves the viability of human pluripotent cells.
        Kazutoshi Takahashi; Chikako Okubo; Michiko Nakamura; Mio Iwasaki; Yuka Kawahara; Tsuyoshi Tabata; Yousuke Miyamoto; Knut Woltjen; Shinya Yamanaka
        Cell reports methods, 28 Feb. 2022, Peer-reviewed
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      • Azacitidine is a potential therapeutic drug for pyridoxine-refractory female X-linked sideroblastic anemia.
        Yuki Morimoto; Kazuhisa Chonabayashi; Hiroshi Kawabata; Chikako Okubo; Makiko Yamasaki-Morita; Misato Nishikawa; Megumi Narita; Azusa Inagaki; Kayoko Nakanishi; Miki Nagao; Akifumi Takaori-Kondo; Yoshinori Yoshida
        Blood advances, 22 Feb. 2022
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      • ERRγ enhances cardiac maturation with T-tubule formation in human iPSC-derived cardiomyocytes
        Kenji Miki; Kohei Deguchi; Misato Nakanishi-Koakutsu; Antonio Lucena-Cacace; Shigeru Kondo; Yuya Fujiwara; Takeshi Hatani; Masako Sasaki; Yuki Naka; Chikako Okubo; Megumi Narita; Ikue Takei; Stephanie C. Napier; Tsukasa Sugo; Sachiko Imaichi; Taku Monjo; Tatsuya Ando; Norihisa Tamura; Kenichi Imahashi; Tomoyuki Nishimoto; Yoshinori Yoshida
        Nature Communications, Dec. 2021
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      • Expression dynamics of HAND1/2 in in vitro human cardiomyocyte differentiation
        Chikako Okubo; Megumi Narita; Azusa Inagaki; Misato Nishikawa; Akitsu Hotta; Shinya Yamanaka; Yoshinori Yoshida
        Stem Cell Reports, Aug. 2021
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      • RNA-Sequencing Analysis of Differentially Expressed Genes in Human iPSC-Derived Cardiomyocytes
        Chikako Okubo; Megumi Narita; Takuya Yamamoto; Yoshinori Yoshida
        Methods in Molecular Biology, 25 Jul. 2021
      • The pluripotent stem cell-specific transcript ESRG is dispensable for human pluripotency
        Kazutoshi Takahashi; Marisa S. Bartolomei; Michiko Nakamura; Chikako Okubo; Zane Kliesmete; Mari Ohnuki; Megumi Narita; Akira Watanabe; Mai Ueda; Yasuhiro Takashima; Ines Hellmann; Shinya Yamanaka
        PLOS Genetics, 25 May 2021
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      • Enhanced engraftment, proliferation, and therapeutic potential in heart using optimized human iPSC-derived cardiomyocytes.
        Chikako Okubo
        Scientific reports, 08 Jan. 2016
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      • Efficient Detection and Purification of Cell Populations Using Synthetic MicroRNA Switches
        Kenji Miki; Kei Endo; Seiya Takahashi; Shunsuke Funakoshi; Ikue Takei; Shota Katayama; Taro Toyoda; Maki Kotaka; Tadashi Takaki; Masayuki Umeda; Chikako Okubo; Misato Nishikawa; Akiko Oishi; Megumi Narita; Ito Miyashita; Kanako Asano; Karin Hayashi; Kenji Osafune; Shinya Yamanaka; Hirohide Saito; Yoshinori Yoshida
        Cell Stem Cell, Jun. 2015
      • Contribution of quantitative changes in individual ionic current systems to the embryonic development of ventricular myocytes: a simulation study
        Chikako Okubo; Hitomi I. Sano; Yasuhiro Naito; Masaru Tomita
        The Journal of Physiological Sciences, 13 Jun. 2013
      • Prediction of potentially unstable electrical activity during embryonic development of rodent ventricular myocytes
        Chikako Okubo; Hitomi Sano; Yasuhiro Naito; Masaru Tomita
        Computing in Cardiology, 2012

      External funds: Kakenhi

      • 魔改造転写因子による細胞運命制御の再定義と生命操作基盤の創出
        Grant-in-Aid for Challenging Research (Pioneering)
        Medium-sized Section 44:Biology at cellular to organismal levels, and related fields
        Kyoto University
        高橋 和利
        From 26 Jun. 2026, To 31 Mar. 2030, Granted
        転写因子;細胞運命操作
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26K21893/
      • Deciphering the deterministic theory of cellular reprogramming mechanism
        Grant-in-Aid for Early-Career Scientists
        Basic Section 44010:Cell biology-related
        Kyoto University
        大久保 周子
        From 01 Apr. 2025, To 31 Mar. 2027, Granted
        多能性幹細胞
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25K18461/
      • Identification of Missing Pieces in Pluripotent Stem Cell Differentiation Focusing on circular RNAs
        Grant-in-Aid for Early-Career Scientists
        Basic Section 38030:Applied biochemistry-related
        Kyoto University
        Chikako Okubo
        From 01 Apr. 2022, To 31 Mar. 2024, Project Closed
        iPS細胞;環状RNA;翻訳;多能性幹細胞;非標準的翻訳
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K14829/
      list
        Last Updated :2026/09/10

        Administration

        Faculty management (title, position)

        • From 01 Apr. 2025, To 31 Mar. 2027
          倫理審査委員会

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