Basic Information

Academic Degree

• 30 Sep. 2022

  京都薬科大学博士（薬学）

Academic Resume (Graduate Schools)

• 京都薬科大学, 大学院博士課程薬学専攻, 修了

Academic Resume (Undergraduate School/Majors)

• 京都薬科大学, 薬学部薬学科, 卒業

Language of Instruction

• Japanese

researchmap URL

• https://researchmap.jp/30975397

Research

Papers

• CN470 is a BET/CBP/p300 multi-bromodomain inhibitor and has an anti-tumor activity against MLL-rearranged acute lymphoblastic leukemia.

  Natsuki Imayoshi; Makoto Yoshioka; Kuniaki Tanaka; Shyh-Ming Yang; Koshi Akahane; Yuki Toda; Shigekuni Hosogi; Takeshi Inukai; Seiji Okada; David J Maloney; Tatsutoshi Nakahata; Junko Takita; Itaru Kato; Eishi Ashihara

  Biochemical and biophysical research communications, 29 Jan. 2022

  
• The CDK4/6-UCHL5-BRD4 axis confers resistance to BET inhibitors in MLL-rearranged leukemia cells by suppressing BRD4 protein degradation.

  Keigo Amari; Satoru Sasagawa; Natsuki Imayoshi; Yuki Toda; Shigekuni Hosogi; Toshihiko Imamura; Eishi Ashihara

  Biochemical and biophysical research communications, 15 Jan. 2022

  
• CG13250, a novel bromodomain inhibitor, suppresses proliferation of multiple myeloma cells in an orthotopic mouse model.

  Natsuki Imayoshi; Makoto Yoshioka; Jay Chauhan; Susumu Nakata; Yuki Toda; Steven Fletcher; Jeffrey W Strovel; Kazuyuki Takata; Eishi Ashihara

  Biochemical and biophysical research communications, 04 Mar. 2017

  

Misc.

• 新規治療薬 基礎 新規ブロモドメイン阻害剤CG13250の多発性骨髄腫に対する抗腫瘍効果

  芦原 英司; 今吉 菜月; Yoshioka Makoto; 中田 晋; Chauhan Jay; 戸田 侑紀; Fletcher Steven; Strovel Jeffrey; 高田 和幸

  International Journal of Myeloma, Apr. 2017

  
• A Novel BRD4 Inhibitor CA2 Suppresses MM Cell Proliferation in an Orthotopic Myeloma Mouse Model

  Natsuki Imayoshi; Makoto Yoshioka; Susumu Nakata; Jay Chauhan; Yoko Kado; Yuki Toda; Steven Fletcher; Jeffrey Strovel; Kazuyuki Takata; Eishi Ashihara

  BLOOD, Dec. 2016

  
• Novel Bromodomain Inhibitors Suppress Proliferation of Multiple Myeloma Cells

  Eishi Ashihara; Ryoko Oki; Natsuki Imayoshi; Makoto Yoshioka; Jeffrey Strovel; Ayako Honjo; Yumi Sakai; Tetsuya Takada; Jay Chauhan; Mithun Raje; Steven Fletcher; Kazuyuki Takata

  BLOOD, Dec. 2015

  

Awards

• 18 Mar. 2017

  京都薬科大学, 2016年度　京都薬科大学優秀研究賞

  Japan, Others
• 14 Oct. 2016

  American Society of Hematology, 2016 ASH Abstract Achievement Award

  United States, International society

External funds: Kakenhi

• ヒストンアセチル化修飾機構阻害薬における血液毒性軽減を目指した毒性メカニズム解析

  Grant-in-Aid for Early-Career Scientists

  Basic Section 47060:Clinical pharmacy-related

  Kyoto University

  今吉 菜月

  From 01 Apr. 2024, To 31 Mar. 2027, Granted

  血液毒性;副作用;がん化学療法;ヒストンアセチル化;がん分子標的治療薬

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K18308/
• Identification of novel target molecules against ALL and discovery of their seed compounds using open access data

  Grant-in-Aid for Scientific Research (C)

  Basic Section 54010:Hematology and medical oncology-related

  Kyoto Pharmaceutical University

  芦原 英司

  From 01 Apr. 2024, To 31 Mar. 2027, Granted

  急性リンパ芽球性白血病;がん分子標的治療;公共データベース;がん分子標的治療薬;ドラッグリポジショニング

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K11528/

Education

Teaching subject(s)

• From 01 Apr. 2025, To 31 Mar. 2026

  Laboratory Practice in Clinical Pharmacy II

  6302, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  Laboratory Practice in Clinical Pharmacy I

  6301, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  Laboratory Practice in Basic Clinical Pharmacy

  4211, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  Research in Pharmaceutical Sciences II

  6202, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2025, To 31 Mar. 2026

  Research in Pharmaceutical Sciences I

  6201, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2025, To 31 Mar. 2026

  Research in Basic Clinical Pharmacy

  3213, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2025, To 31 Mar. 2026

  Research in Pharmaceutical Sciences III

  6203, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2025, To 31 Mar. 2026

  Seminar in Basic Clinical Pharmacy

  2313, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Advanced Hospital Pharmacy

  6008, Fall, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Seminar for Clinical Pharmacy III

  6103, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Seminar for Clinical Pharmacy II

  6102, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Seminar for Clinical Pharmacy I

  6101, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Laboratory Practice in Clinical Pharmacy I

  6301, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Laboratory Practice in Basic Clinical Pharmacy

  4211, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Laboratory Practice in Clinical Pharmacy II

  6302, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Research in Pharmaceutical Sciences III

  6203, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Research in Pharmaceutical Sciences II

  6202, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Research in Pharmaceutical Sciences I

  6201, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Research in Basic Clinical Pharmacy

  3213, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar for Clinical Pharmacy II

  6102, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar for Clinical Pharmacy I

  6101, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar in Basic Clinical Pharmacy

  2313, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar for Clinical Pharmacy III

  6103, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Laboratory Practice in Basic Clinical Pharmacy

  4211, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Laboratory Practice in Clinical Pharmacy II

  6302, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Laboratory Practice in Clinical Pharmacy I

  6301, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Research in Basic Clinical Pharmacy

  3213, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Research in Pharmaceutical Sciences III

  6203, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Research in Pharmaceutical Sciences II

  6202, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Research in Pharmaceutical Sciences I

  6201, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar for Clinical Pharmacy III

  6103, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar for Clinical Pharmacy II

  6102, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar for Clinical Pharmacy I

  6101, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Hospital Pharmacy

  6008, Fall, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar in Basic Clinical Pharmacy

  2313, Year-long, Graduate School of Pharmaceutical Sciences, 2