Basic Information

Email Address

• Email Address

  michikawa.takayuki.2ekyoto-u.ac.jp

Academic Degree

• 31 Mar. 1989

  Master's Degree (Tokyo University of Science)
• 29 Mar. 1995

  PhD (The University of Tokyo)

Academic Resume (Undergraduate School/Majors)

• Tokyo University of Science, Faculty of Science and Technology, Department of Applied Biological Science, Graduation

ID,URL

• J-Global ID

  202301000763554870

• Researcher number

  90282516

researchmap URL

• https://researchmap.jp/takayuki_michikawa

Research

Research Topics, Overview of the research

• Research Topics

  Analysis of the Mechanisms Underlying Brain Function Using Large-Scale Fluorescent Brain Imaging

• Overview of the research

  Using microscopes developed in-house, I measure neuronal activity throughout the dorsal regions of the cerebral cortex and cerebellar cortex of awake mice via fluorescent calcium imaging to analyze the brain mechanisms that control motor function, perception, and sleep-wake states.

External funds: Kakenhi

• Analysis of the brain mechanisms that determine the speed and period of movement

  Grant-in-Aid for Scientific Research (C)

  Basic Section 46030:Function of nervous system-related

  Kyoto University;Institute of Physical and Chemical Research

  Takayuki Michikawa

  From 01 Apr. 2022, To 31 Mar. 2025, Project Closed

  運動制御;蛍光共鳴エネルギー移動;大脳;小脳;マウス;リッキング;マクロ顕微鏡;カルシウムイメージング;ベイズ推定;独立成分分析

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K06491/
• The study for cerebellar cortical information processing using functional imaging and three-dimensional reconstruction

  Grant-in-Aid for Scientific Research (C)

  The Institute of Physical and Chemical Research;Saitama University

  TAKAYUKI MICHIKAWA

  From 01 Apr. 2012, To 31 Mar. 2015, Project Closed

  カルシウムイメージング;国際情報交換

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24500476/
• Molecular basis underlying the generation of spatiotemporal patterns of cytosolic calcium dynamics

  Grant-in-Aid for Scientific Research (B)

  The Institute of Physical and Chemical Research

  Takayuki MICHIKAWA

  From 01 Apr. 2008, To 31 Mar. 2011, Project Closed

  カルシウムシグナル;細胞内情報伝達;セカンドメッセンジャー;イノシトール三リン酸;カルシウム放出チャネル;カルシウムポンプ;ホスフォリパーゼC;カルシウム振動;システムズバイオロジー;情報伝達;蛍光共鳴エネルギー移動;イオンチャネル;カルシウム

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20370054/
• イノシトール三リン酸受容体のリガンド結合によるチャネル開口機構の解析

  Grant-in-Aid for Scientific Research (C)

  The University of Tokyo

  道川 貴章

  From 01 Apr. 2005, To 31 Mar. 2007, Project Closed

  カルシウムシグナル;リガンド;クラスター;イオンチャンネル;細胞内情報伝達;X線結晶構造;スプライシング;レドックス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17570128/
• 代謝型グルタミン酸受容体による細胞内カルシウム振動形成機構の解析

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  The University of Tokyo

  道川 貴章

  From 01 Apr. 2005, To 31 Mar. 2006, Project Closed

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17017013/
• 瞬目反射条件付けに伴う小脳皮質活動の可視化

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  The University of Tokyo

  道川 貴章

  From 01 Apr. 2003, To 31 Mar. 2004, Project Closed

  神経科学;脳・神経;カルシウム;学習

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15016036/
• Molecular mechanisms underlying the generation of spatiotemporal patterns of cytoplasmic calcium

  Grant-in-Aid for Scientific Research (C)

  The University of Tokyo

  Takayuki MICHIKAWA

  From 01 Apr. 2002, To 31 Mar. 2004, Project Closed

  カルシウムシグナル;イノシトール3リン酸;遺伝子クローニング;レセプター;細胞内局在;小胞体;リガンド結合;イオンチャネル;カルシウムチャネル;システイン, calcium signal;inositol trisphosphate;molecular cloning;receptor;intracellular localization;endplasmic reticulum;ligand binding;ionic channel

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14580667/
• 瞬目反射条件付けに伴う小脳皮質活動の可視化

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  The University of Tokyo

  道川 貴章

  From 01 Apr. 2002, To 31 Mar. 2003, Project Closed

  神経科学;脳・神経;カルシウム;学習

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14017025/
• マウス瞬目反射条件付けに伴う小脳皮質活動の可視化

  Grant-in-Aid for Scientific Research on Priority Areas (C)

  Biological Sciences

  The University of Tokyo

  道川 貴章

  From 01 Apr. 2001, To 31 Mar. 2002, Project Closed

  瞬目反射条件付け;小脳;トランスジェニックマウス;cameleon;アデノウイルス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13210043/
• Physiological significance of feedback regulation of inositol 1,4,5-trisphosphate receptor by cytoplasmic calcium

  Grant-in-Aid for Scientific Research (C)

  The University of Tokyo

  Takayuki MICHIKAWA

  From 01 Apr. 2000, To 31 Mar. 2002, Project Closed

  イノシトール3リン酸;セカンドメッセンジャー;カルシウム;イオンチャネル;カルモデュリン;カルモジュリン;DT-40;B細胞抗原受容体, inositol 1,4,5-trisphosphate;calcium;second messenger;ionic channel

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12680652/
• 小脳プルキンエ細胞におけるシナプス伝達の長期抑圧の分子機構の解析

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  Biological Sciences

  The University of Tokyo

  道川 貴章

  From 01 Apr. 1999, To 31 Mar. 2001, Project Closed

  シナプス可塑性;プルキンエ細胞;長期抑圧;カルシウム;セカンドメッセンジャー;カルモジュリン;イノシトール3リン酸受容体

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11170213/
• イノシトール3リン酸受容体のチャネル構成部位の構造と機能の解析

  Grant-in-Aid for Encouragement of Young Scientists (A)

  The University of Tokyo

  道川 貴章

  From 01 Apr. 1998, To 31 Mar. 2000, Project Closed

  カルシウムシグナリング;カルシウムチャネル;細胞内情報伝達;セカンドメッセンジャー;遺伝子ノックアウト;R23-11細胞;人工脂質二重膜;イノシトール3リン酸受容体

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10780494/
• Analysis of the molecular dynamics of intracellular signal transduction by chromophore, assisted inactivatid

  Grant-in-Aid for Scientific Research (B)

  The University of Tokyo

  Katsuhiko MIKOSHIBA

  From 01 Apr. 1998, To 31 Mar. 2000, Project Closed

  IP_3受容体;カルモジュリン;分子認識;カルシウム;IP_3;マイクロCALI;レーザー;GFP;神経成長円錐;小胞体;機能分子不活化法;蛍光エネルギー転移;IP3, IPィイD23ィエD2 receptor;Calmodulin;molecular recognition;Calcium

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10558112/
• Study of the Structure-Function of IPィイD23ィエD2 Receptor/CaィイD12+ィエD1 Release Channel and IPィイD23ィエD2/CaィイD12+ィエD1 Signaling

  Grant-in-Aid for Scientific Research (B)

  The Institute of Physical and Chemical Research (RIKEN);The University of Tokyo

  Teiichi FURUICHI

  From 01 Apr. 1998, To 31 Mar. 2000, Project Closed

  IP_3受容体;Ca^<2+>シグナル伝達;カルモジュリン;アポトーシス;単一チャネル記録;細胞質分裂;リガンド結合;カスパーゼ3;セカンドメッセンジャー;カルシウムチャネル;イノシトール1,4,5-三リン酸;IP_3誘導Ca^<2+>放出, IPィイD23ィエD2 receptor;CaィイD12+ィエD1 signaling;Calmodulin;Ligand binding;Apoptosis;Single channel recording;Cytokinesis;Caspase-3

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10490007/
• Studies on the molecular mechanism of calcium signaling and the role of IP3 receptor in development and differentiation

  Grant-in-Aid for Scientific Research (A)

  The University of Tokyo

  Katsuhiko MIKOSHIBA

  From 01 Apr. 1997, To 31 Mar. 1999, Project Closed

  IP_3 受容体;Ca^<2+> 動態;神経突起伸長;成長円錐;マイクロインジェクション;Ca^<2+> 波;IP3受容体;Ca2+動態;神経伝達物質;LTP;胚軸形成;LTD;IP_3;IP_3受容体;カルシウム;背側化;腹側化;二次軸形成;BMP4;IP_3誘導カルシウム放出, IP3 receptor;Ca2+ activation;nerve growth;Growth cone;Microinjection;Ca2+ waves

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09308030/
• Regulatory mechanism of neurotransmitter release

  Grant-in-Aid for international Scientific Research

  The University of Tokyo

  Matsuhiko MIKOSHIBA

  From 01 Apr. 1996, To 31 Mar. 1998, Project Closed

  IP_4;IP_5;IP_6;シナプトタグミン;C2Aドメイン;C2Bドメイン;イノシトールポリリン酸;神経伝達物質放出;カルシウム;シナプス小胞;シウプス伝達, IP_4;IP_5;IP_6;synaptotagmin;neurotransmitter release;inositol polyphosphate;C2A domain;C2B domain

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08044254/
• Cellular dynamics of functional molecules and second messengers during synaptic transmission

  Grant-in-Aid for Scientific Research (A)

  The University of Tokyo

  Katsuhiko MIKOSHIBA

  From 01 Apr. 1995, To 31 Mar. 1997, Project Closed

  神経伝達物質;神経伝達;イノシトールポリリン酸;シナプス;シナプトタグミン;シナプス小胞;IP_3;IP_3レセプター;カルシウムイオン;情報伝達;カルシウムチャネル;小胞体;セカンドメッセンジャー, neurotransmitter;neurotransmission;synaptotagmin;inositol polyphosphate;synapse;sinaptic vesicle

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07508004/

External funds: others

• Development of Comprehensive Measurement Techniques for Central Nervous System Activity Aimed at Elucidating Motor Control Mechanisms

  JST, CREST

  From 01 Oct. 2024, To 31 Mar. 2030

  Takayuki Michikawa

  Keisuke Isobe, Hirokazu Tanaka

  Principal Investigator

Education

Student achievements: Papers

• Volitional and forced running ability in mice lacking intact primary motor cortex

  Abo,R., Ishikawa, M., Shinohara, R., Michikawa*, T., and Imayoshi, I

  14 Aug. 2025, Corresponding author, Front. Neural Circuits, 19, 1630932, Peer-reviewed, English, Scientific journal, False

  https://doi.org/10.3389/fncir.2025.1630932

Student achievements: Presentations

• Establishment of a method for simultaneous measurement of cerebellar complex spikes and electroencephalogram in mice

  Rio Shinohara, Itaru Imayoshi, Takayuki Michikawa

  The 48th Annual Meeting of the Japan Neuroscience Society, 25 Jul. 2025, From 24 Jul. 2025, To 27 Jul. 2025, Not invited, English, Poster presentation
• Investing a methods of attaching a metal plate to the mouse spinal cord for large-scale imaging

  Mei Ishikawa, Itaru Imayoshi, Takayuki Michikawa

  The 48th Annual Meeting of the Japan Neuroscience Society, 26 Jul. 2025, From 24 Jul. 2025, To 27 Jul. 2025, Not invited, English, Poster presentation

Administration

Faculty management (title, position)

• From 01 Apr. 2023

  共同利用機器等委員会　委員
• From 01 Apr. 2023

  化学物質管理委員会　委員