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Oohashi, Shinya

KYOTO UNIVERSITY HOSPITAL Program-Specific Associate Professor

Oohashi, Shinya
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    Last Updated :2022/06/24

    Basic Information

    Academic Degree

    • 博士(医学)(京都大学)

    ID,URL

    researchmap URL

    list
      Last Updated :2022/06/24

      Research

      Research Topics, Overview of the research

      • Research Topics

        Elucidation a mechanism of esophageal cancer development
      • Overview of the research

        We are conducting in vitro studies using human esophageal epithelial cells, and in vivo studies using ALDH2 genetically modified mice to elucidate the molecular mechanisms of esophageal squamous carcinogenesis, in particularly focusing on acetaldehyde which is generated from alcohol metabolism. We are also conducting basic and/or clinical research aimed at developing novel anticancer therapy for esophageal cancer.

      Research Areas

      • Natural sciences, Basic analysis

      Papers

      • Visceral fat obesity is the key risk factor for the development of reflux erosive esophagitis in 40–69-years subjects
        Shinya Ohashi; Takahisa Maruno; Keita Fukuyama; Osamu Kikuchi; Tomohiko Sunami; Yuki Kondo; Seiichiro Imai; Aki Matsushima; Kazuyo Suzuki; Fumika Usui; Masahiro Yakami; Atsushi Yamada; Hiroyoshi Isoda; Shigemi Matsumoto; Hiroshi Seno; Manabu Muto; Mayumi Inoue
        Esophagus, 12 Jun. 2021
      • Repeated talaporfin sodium photodynamic therapy for esophageal cancer: safety and efficacy
        Masashi Tamaoki; Akira Yokoyama; Takahiro Horimatsu; Kenshiro Hirohashi; Yusuke Amanuma; Hirokazu Higuchi; Yosuke Mitani; Masahiro Yoshioka; Shinya Ohashi; Manabu Muto
        Esophagus, 09 Jun. 2021
      • FGFR2 maintains cancer cell differentiation via AKT signaling in esophageal squamous cell carcinoma.
        Osamu Maehara; Goki Suda; Mitsuteru Natsuizaka; Taku Shigesawa; Gouki Kanbe; Megumi Kimura; Masaya Sugiyama; Masashi Mizokami; Masato Nakai; Takuya Sho; Kenichi Morikawa; Koji Ogawa; Shinya Ohashi; Shingo Kagawa; Hideaki Kinugasa; Seiji Naganuma; Naoto Okubo; Shunsuke Ohnishi; Hiroshi Takeda; Naoya Sakamoto
        Cancer biology & therapy, 03 Jun. 2021
      • Association of local complete response with prognosis after salvage photodynamic therapy for esophageal squamous cell carcinoma
        Yusuke Amanuma; Takahiro Horimatsu; Shinya Ohashi; Masashi Tamaoki; Manabu Muto
        Digestive Endoscopy, Mar. 2021
      • Cancer of unknown primary with EGFR mutation successfully treated with targeted therapy directed by clinical next-generation sequencing: a case report
        Yosuke Mitani; Masashi Kanai; Tadayuki Kou; Shigeki Kataoka; Keitaro Doi; Junichi Matsubara; Shinya Ohashi; Shigemi Matsumoto; Manabu Muto
        BMC Cancer, Dec. 2020
      • Autophagy mitigates ethanol-induced mitochondrial dysfunction and oxidative stress in esophageal keratinocytes
        Prasanna M. Chandramouleeswaran; Manti Guha; Masataka Shimonosono; Kelly A. Whelan; Hisatsugu Maekawa; Uma M. Sachdeva; Gordon Ruthel; Sarmistha Mukherjee; Noah Engel; Michael V. Gonzalez; James Garifallou; Shinya Ohashi; Andres J. Klein-Szanto; Clementina A. Mesaros; Ian A. Blair; Renata Pellegrino da Silva; Hakon Hakonarson; Eishi Noguchi; Joseph A. Baur; Hiroshi Nakagawa
        PLOS ONE, 23 Sep. 2020
      • E487K-Induced Disorder in Functionally Relevant Dynamics of Mitochondrial Aldehyde Dehydrogenase 2
        Shigeyuki Matsumoto; Mitsugu Araki; Yuta Isaka; Fumie Ono; Kenshiro Hirohashi; Shinya Ohashi; Manabu Muto; Yasushi Okuno
        Biophysical Journal, Jul. 2020, Peer-reviewed
      • Synthetic Lethality with Trifluridine/Tipiracil and Checkpoint Kinase 1 Inhibitor for Esophageal Squamous Cell Carcinoma
        Shinya Ohashi; Osamu Kikuchi; Yukie Nakai; Tomomi Ida; Tomoki Saito; Yuki Kondo; Yoshihiro Yamamoto; Yosuke Mitani; Trang H. Nguyen Vu; Keita Fukuyama; Hiroshi Tsukihara; Norihiko Suzuki; Manabu Muto
        Molecular cancer therapeutics, 01 Jun. 2020, Peer-reviewed
      • Experimental model for the irradiation-mediated abscopal effect and factors influencing this effect.
        Kiichiro Baba; Motoo Nomura; Shinya Ohashi; Takuya Hiratsuka; Yukie Nakai; Tomoki Saito; Yuki Kondo; Keita Fukuyama; Osamu Kikuchi; Atsushi Yamada; Junichi Matsubara; Kenshiro Hirohashi; Yosuke Mitani; Ayaka Mizumoto; Manabu Muto
        American journal of cancer research, 2020, Peer-reviewed
      • 多発ヨード不染帯を有する食道早期癌内視鏡切除後患者に対するTS-1療法の食道内多発癌抑制効果に関する検討
        玉置 将司; 堀松 高博; 横山 顕礼; 天沼 裕介; 宮本 心一; 山田 敦; 野村 基雄; 船越 真木子; 松本 繁巳; 大橋 真也; 青山 育雄; 石川 秀樹; 武藤 学
        日本消化管学会雑誌, Jan. 2020, Peer-reviewed
      • 食道癌に対する根治的CRTとNivolumab併用による医師主導治験 Trial in progress
        野村 基雄; 清水 充子; 大橋 真也; 三梨 桂子; 加藤 健; 小島 隆嗣; 坂中 克行; 武藤 学
        日本癌治療学会学術集会抄録集, Oct. 2019
      • 食道癌に対する根治的CRTとNivolumab併用による医師主導治験 Trial in progress
        野村 基雄; 清水 充子; 大橋 真也; 三梨 桂子; 加藤 健; 小島 隆嗣; 坂中 克行; 武藤 学
        日本癌治療学会学術集会抄録集, Oct. 2019, Peer-reviewed
      • 食道癌に対するnivolumabと化学放射線療法(NOBEL) 治験進行中(NivOlumaB and chemoradiotherapy for EsophageaL cancer(NOBEL)(Trial in progress))
        野村 基雄; 清水 充子; 大橋 真也; 三梨 桂子; 加藤 健; 小島 隆嗣; 坂中 克行; 武藤 学
        日本食道学会学術集会プログラム・抄録集, Jun. 2019, Peer-reviewed
      • Clinical Outcome of Salvage Photodynamic Therapy Using Talaporfin Sodium for Esophageal Cancer in Our Clinical Practice After Pharmaceutical Approval
        Yusuke Amanuma; Takahiro Horimatsu; Shinya Ohashi; Masashi Tamaoki; Manabu Muto
        Nippon Laser Igakkaishi, 15 Apr. 2019
      • Management for Phototoxicity after Photodynamic Therapy Using Talaporfin Sodium
        Masashi Tamaoki; Shinya Ohashi; Kenshiro Hirohashi; Masahiro Yoshioka; Yusuke Amanuma; Manabu Muto
        Nippon Laser Igakkaishi, 15 Apr. 2019
      • Patient-derived tumor models of esophageal cancer
        Tomoki Saito; Shinya Ohashi; Ayaka Mizumoto; Manabu Muto
        Chick Chorioallantoic Membrane Model and Precision Cancer Therapy, 2019
      • Alcohol-Induced DNA Injury in Esophageal Squamous Cell Carcinoma
        Masashi Tamaoki; Yusuke Amanuma; Shinya Ohashi; Manabu Muto
        Alcoholic/Non-Alcoholic Digestive Diseases, 2019
      • Three-Dimensional Organoids Reveal Therapy Resistance of Esophageal and Oropharyngeal Squamous Cell Carcinoma Cells.
        Takashi Kijima; Hiroshi Nakagawa; Masataka Shimonosono; Prasanna M Chandramouleeswaran; Takeo Hara; Varun Sahu; Yuta Kasagi; Osamu Kikuchi; Koji Tanaka; Veronique Giroux; Amanda B Muir; Kelly A Whelan; Shinya Ohashi; Seiji Naganuma; Andres J Klein-Szanto; Yoshiaki Shinden; Ken Sasaki; Itaru Omoto; Yoshiaki Kita; Manabu Muto; Adam J Bass; J Alan Diehl; Gregory G Ginsberg; Yuichiro Doki; Masaki Mori; Yasuto Uchikado; Takaaki Arigami; Narayan G Avadhani; Devraj Basu; Anil K Rustgi; Shoji Natsugoe
        Cellular and molecular gastroenterology and hepatology, 2019, Peer-reviewed
      • Age-related remodelling of oesophageal epithelia by mutated cancer drivers.
        Akira Yokoyama; Nobuyuki Kakiuchi; Tetsuichi Yoshizato; Yasuhito Nannya; Hiromichi Suzuki; Yasuhide Takeuchi; Yusuke Shiozawa; Yusuke Sato; Kosuke Aoki; Soo Ki Kim; Yoichi Fujii; Kenichi Yoshida; Keisuke Kataoka; Masahiro M Nakagawa; Yoshikage Inoue; Tomonori Hirano; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Masashi Sanada; Yoshitaka Nishikawa; Yusuke Amanuma; Shinya Ohashi; Ikuo Aoyama; Takahiro Horimatsu; Shin'ichi Miyamoto; Shigeru Tsunoda; Yoshiharu Sakai; Maiko Narahara; J B Brown; Yoshitaka Sato; Genta Sawada; Koshi Mimori; Sachiko Minamiguchi; Hironori Haga; Hiroshi Seno; Satoru Miyano; Hideki Makishima; Manabu Muto; Seishi Ogawa
        Nature, Jan. 2019, Peer-reviewed
      • Combination treatment with highly bioavailable curcumin and NQO1 inhibitor exhibits potent antitumor effects on esophageal squamous cell carcinoma.
        Mizumoto A; Ohashi S; Kamada M; Saito T; Nakai Y; Baba K; Hirohashi K; Mitani Y; Kikuchi O; Matsubara J; Yamada A; Takahashi T; Lee H; Okuno Y; Kanai M; Muto M
        J Gastroenterology, 2019, Peer-reviewed
      • Protective effects of Alda-1, an ALDH2 activator, on alcohol-derived DNA damage in the esophagus of human ALDH2*2(Glu504Lys) knock-in mice.
        Hirohashi K; Ohashi S; Amanuma Y; Nakai Y; Ida T; Baba K; Mitani Y; Mizumoto A; Yamamoto Y; Kikuchi O; Matsubara J; Yamada A; Miyamoto S; Seno H; Matsuda T; Muto M
        Carcinogenesis, 2019, Peer-reviewed
      • IL-6 mediates cross-talk between activated fibroblasts and tumor cells in the tumor microenvironment.
        Karakasheva TA; Lin EW; Tang Q; Qiao E; Waldron TJ; Soni M; Klein-Szanto AJ; Sahu V; Basu D; Ohashi S; Baba K; Giaccone ZT; Wallker SR; Frank DA; Wileyto EP; Long Q; Dunagin M; Raj A; Diehl JA; Bass AJ; Rustgi AK
        Cancer Res, 2018, Peer-reviewed
      • Fibroblast growth factor-2-mediated FGFR/Erk signaling supports maintenance of cancer stem-like cells in esophageal squamous cell carcinoma
        Osamu Maehara; Goki Suda; Mitsuteru Natsuizaka; Shunsuke Ohnishi; Yoshito Komatsu; Fumiyuki Sato; Masato Nakai; Takuya Sho; Kenichi Morikawa; Koji Ogawa; Tomoe Shimazaki; Megumi Kimura; Ayaka Asano; Yoshiyuki Fujimoto; Shinya Ohashi; Shingo Kagawa; Hideaki Kinugasa; Seiji Naganuma; Kelly A. Whelan; Hiroshi Nakagawa; Koji Nakagawa; Hiroshi Takeda; Naoya Sakamoto
        CARCINOGENESIS, Nov. 2017, Peer-reviewed
      • Molecular Mechanisms of Acetaldehyde-Mediated Carcinogenesis in Squamous Epithelium
        Ayaka Mizumoto; Shinya Ohashi; Kenshiro Hirohashi; Yusuke Amanuma; Tomonari Matsuda; Manabu Muto
        INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Sep. 2017, Peer-reviewed
      • Distinct effects of EGFR inhibitors on epithelial- and mesenchymal-like esophageal squamous cell carcinoma cells.
        Yoshioka M; Ohashi S; Ida T; Nakai Y; Kikuchi O; Amanuma Y; Matsubara J; Yamada A; Miyamoto S; Natsuizaka M; Nakagawa H; Chiba T; Seno H; Muto M
        Journal of experimental & clinical cancer research : CR, Aug. 2017, Peer-reviewed
      • Distinct effects of EGFR inhibitors on epithelial- and mesenchymal-like esophageal squamous cell carcinoma cells
        Masahiro Yoshioka; Shinya Ohashi; Tomomi Ida; Yukie Nakai; Osamu Kikuchi; Yusuke Amanuma; Junichi Matsubara; Atsushi Yamada; Shin'ichi Miyamoto; Mitsuteru Natsuizaka; Hiroshi Nakagawa; Tsutomu Chiba; Hiroshi Seno; Manabu Muto
        JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, Aug. 2017, Peer-reviewed
      • Establishment of a Quick and Highly Accurate Breath Test for ALDH2 Genotyping
        Ikuo Aoyama; Shinya Ohashi; Yusuke Amanuma; Kenshiro Hirohashi; Ayaka Mizumoto; Makiko Funakoshi; Mihoko Tsurumaki; Yukie Nakai; Katsuyuki Tanaka; Mariko Hanada; Aki Uesaka; Tsutomu Chiba; Manabu Muto
        CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY, Jun. 2017, Peer-reviewed
      • アルコール代謝と頭頚部癌 -広域発がん現象ー
        大橋 真也
        日本臨床増刊号, Feb. 2017, Invited
      • 食道扁平上皮発がんと遺伝子異常
        大橋 真也
        日本消化器病学会雑誌, Nov. 2016, Peer-reviewed
      • Alcohol Consumption and Multiple Dysplastic Lesions Increase Risk of Squamous Cell Carcinoma in the Esophagus, Head, and Neck
        Chikatoshi Katada; Tetsuji Yokoyama; Tomonori Yano; Kazuhiro Kaneko; Ichiro Oda; Yuichi Shimizu; Hisashi Doyama; Tomoyuki Koike; Kohei Takizawa; Motohiro Hirao; Hiroyuki Okada; Takako Yoshii; Kazuo Konishi; Takenori Yamanouchi; Takashi Tsuda; Tai Omori; Nozomu Kobayashi; Tadakazu Shimoda; Atsushi Ochiai; Yusuke Amanuma; Shinya Ohashi; Tomonari Matsuda; Hideki Ishikawa; Akira Yokoyama; Manabu Muto
        GASTROENTEROLOGY, Nov. 2016, Peer-reviewed
      • Novel EGFR-targeted strategy with hybrid peptide against oesophageal squamous cell carcinoma
        Osamu Kikuchi; Shinya Ohashi; Tomohisa Horibe; Masayuki Kohno; Yukie Nakai; Shin'ichi Miyamoto; Tsutomu Chiba; Manabu Muto; Koji Kawakami
        SCIENTIFIC REPORTS, Mar. 2016, Peer-reviewed
      • Carcinogenesis and genetic alterations in squamous epithelium of the esophagus
        Shinya Ohashi; Manabu Muto
        Journal of Japanese Society of Gastroenterology, 2016, Peer-reviewed
      • ALDH2 modulates autophagy flux to regulate acetaldehyde-mediated toxicity thresholds
        Koji Tanaka; Kelly A. Whelan; Prasanna M. Chandramouleeswaran; Shingo Kagawa; Sabrina L. Rustgi; Chiaki Noguchi; Manti Guha; Satish Srinivasan; Yusuke Amanuma; Shinya Ohashi; Manabu Muto; Andres J. Klein-Szanto; Eishi Noguchi; Narayan G. Avadhani; Hiroshi Nakagawa
        AMERICAN JOURNAL OF CANCER RESEARCH, 2016, Peer-reviewed
      • Recent Advances From Basic and Clinical Studies of Esophageal Squamous Cell Carcinoma
        Shinya Ohashi; Shin'ichi Miyamoto; Osamu Kikuchi; Tomoyuki Goto; Yusuke Amanuma; Manabu Muto
        GASTROENTEROLOGY, Dec. 2015, Peer-reviewed
      • Protective role of ALDH2 against acetaldehyde - derived DNA damage in oesophageal squamous epithelium
        Yusuke Amanuma; Shinya Ohashi; Yoshiro Itatani; Mihoko Tsurumaki; Shun Matsuda; Osamu Kikuchi; Yukie Nakai; Shin'ichi Miyamoto; Tsunehiro Oyama; Toshihiro Kawamoto; Kelly A. Whelan; Hiroshi Nakagawa; Tsutomu Chiba; Tomonari Matsuda; Manabu Muto
        SCIENTIFIC REPORTS, Sep. 2015, Peer-reviewed
      • EGFR inhibitors prevent induction of cancer stem-like cells in esophageal squamous cell carcinoma by suppressing epithelial-mesenchymal transition
        Fumiyuki Sato; Yoshimasa Kubota; Mitsuteru Natsuizaka; Osamu Maehara; Yutaka Hatanaka; Katsuji Marukawa; Katsumi Terashita; Goki Suda; Shunsuke Ohnishi; Yuichi Shimizu; Yoshito Komatsu; Shinya Ohashi; Shingo Kagawa; Hideaki Kinugasa; Kelly A. Whelan; Hiroshi Nakagawa; Naoya Sakamoto
        CANCER BIOLOGY & THERAPY, Jun. 2015, Peer-reviewed
      • Cellular senescence checkpoint function determines differential Notch1-dependent oncogenic and tumor-suppressor activities
        S. Kagawa; M. Natsuizaka; K. A. Whelan; N. Facompre; S. Naganuma; S. Ohashi; H. Kinugasa; A. M. Egloff; D. Basu; P. A. Gimotty; A. J. Klein-Szanto; A. J. Bass; K-K Wong; J. A. Diehl; A. K. Rustgi; H. Nakagawa
        ONCOGENE, Apr. 2015, Peer-reviewed
      • Novel 5-fluorouracil-resistant human esophageal squamous cell carcinoma cells with dihydropyrimidine dehydrogenase overexpression
        Osamu Kikuchi; Shinya Ohashi; Yukie Nakai; Shunsaku Nakagawa; Kazuaki Matsuoka; Takashi Kobunai; Teiji Takechi; Yusuke Amanuma; Masahiro Yoshioka; Tomomi Ida; Yoshihiro Yamamoto; Yasushi Okuno; Shin'ichi Miyamoto; Hiroshi Nakagawa; Kazuo Matsubara; Tsutomu Chiba; Manabu Muto
        AMERICAN JOURNAL OF CANCER RESEARCH, 2015, Peer-reviewed
      • Preclinical Validation of Talaporfin Sodium-Mediated Photodynamic Therapy for Esophageal Squamous Cell Carcinoma
        Shinya Ohashi; Osamu Kikuchi; Mihoko Tsurumaki; Yukie Nakai; Hiroi Kasai; Takahiro Horimatsu; Shin'ichi Miyamoto; Akira Shimizu; Tsutomu Chiba; Manabu Muto
        PLOS ONE, Aug. 2014, Peer-reviewed
      • EGFR Inhibitors Eliminate Esophageal Cancer Stem Cells by Suppressing Epithelial-Mesenchymal Transition
        Mitsuteru Natsuizaka; Bongani Kaimila; Yoshimasa Kubota; Yutaka Hatanaka; Katsuji Marukawa; Katsumi Terashita; Fumiyuki Satou; Shunsuke Ohnishi; Goki Suda; Shinya Ohashi; Shingo Kagawa; Kelly A. Whelan; Anil K. Rustgi; Hiroshi Nakagawa; Naoya Sakamoto
        GASTROENTEROLOGY, May 2014, Peer-reviewed
      • Impairment of aldehyde dehydrogenase 2 increases accumulation of acetaldehyde-derived DNA damage in the esophagus after ethanol ingestion
        Yoshiyuki Yukawa; Shinya Ohashi; Yusuke Amanuma; Yukie Nakai; Mihoko Tsurumaki; Osamu Kikuchi; Shin'ichi Miyamoto; Tsunehiro Oyama; Toshihiro Kawamoto; Tsutomu Chiba; Tomonari Matsuda; Manabu Muto
        AMERICAN JOURNAL OF CANCER RESEARCH, 2014, Peer-reviewed
      • Hypoxia induces IGFBP3 in esophageal squamous cancer cells through HIF-1 alpha-mediated mRNA transcription and continuous protein synthesis
        Mitsuteru Natsuizaka; Seiji Naganuma; Shingo Kagawa; Shinya Ohashi; Azal Ahmadi; Harry Subramanian; Sanders Chang; Kei J. Nakagawa; Xinjun Ji; Stephen A. Liebhaber; Andres J. Klein-Szanto; Hiroshi Nakagawa
        FASEB JOURNAL, Jun. 2012, Peer-reviewed
      • Notch receptor inhibition reveals the importance of cyclin D1 and Wnt signaling in invasive esophageal squamous cell carcinoma
        Seiji Naganuma; Kelly A. Whelan; Mitsuteru Natsuizaka; Shingo Kagawa; Hideaki Kinugasa; Sanders Chang; Harry Subramanian; Ben Rhoades; Shinya Ohashi; Hiroshi Itoh; Meenhard Herlyn; J. Alan Diehl; Phyllis A. Gimotty; Andres J. Klein-Szanto; Hiroshi Nakagawa
        AMERICAN JOURNAL OF CANCER RESEARCH, 2012, Peer-reviewed
      • A NOTCH3-Mediated Squamous Cell Differentiation Program Limits Expansion of EMT-Competent Cells That Express the ZEB Transcription Factors
        Shinya Ohashi; Mitsuteru Natsuizaka; Seiji Naganuma; Shingo Kagawa; Sotai Kimura; Hiroshi Itoh; Ross A. Kalman; Momo Nakagawa; Douglas S. Darling; Devraj Basu; Phyllis A. Gimotty; Andres J. Klein-Szanto; J. Alan Diehl; Meenhard Herlyn; Hiroshi Nakagawa
        CANCER RESEARCH, Nov. 2011, Peer-reviewed
      • MMP7 and activation of IGF1R A new insight into anti-EGFR therapeutic resistance in metastatic colorectal cancer
        Shinya Ohashi; Mitsuteru Natsuizaka; Hiroshi Nakagawa
        CANCER BIOLOGY & THERAPY, Jan. 2011, Peer-reviewed
      • 食道扁平上皮癌においてZEB1およびZEB2は腫瘍浸潤およびEMTを促進する(ZEB1 and ZEB2 promote tumor invasion and EMT in esophageal squamous cell carcinoma)
        長沼 誠二; 大橋 真也; 木村 相泰; 夏井坂 光輝; 中川 裕; 伊藤 浩史
        日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2010, Peer-reviewed
      • NOTCH1 and NOTCH3 Coordinate Esophageal Squamous Differentiation Through a CSL-Dependent Transcriptional Network
        Shinya Ohashi; Mitsuteru Natsuizaka; Yumi Yashiro-Ohtani; Ross A. Kalman; Momo Nakagawa; Lizi Wu; Andres J. Klein-Szanto; Meenhard Herlyn; J. Alan Diehl; Jonathan P. Katz; Warren S. Pear; John T. Seykora; Hiroshi Nakagawa
        GASTROENTEROLOGY, Dec. 2010, Peer-reviewed
      • Insulin-like growth factor-binding protein-3 promotes transforming growth factor-beta 1-mediated epithelial-to-mesenchymal transition and motility in transformed human esophageal cells
        Mitsuteru Natsuizaka; Shinya Ohashi; Gabrielle S. Wong; Azal Ahmadi; Ross A. Kalman; Daniela Budo; Andres J. Klein-Szanto; Meenhard Herlyn; J. Alan Diehl; Hiroshi Nakagawa
        CARCINOGENESIS, Aug. 2010, Peer-reviewed
      • Regression of B-Cell Lymphoma of the Liver with Hepatitis C Virus Infection After Treatment with Pegylated Interferon-alpha and Ribavirin
        Yayoi Oda; Tadayuki Kou; Masaki Watanabe; Yojiro Sakuma; Nori Taguchi; Yoko Kato; Yasushi Kudo; Atsushi Yamauchi; Yasushi Sugiura; Shinya Ohashi; Masanori Asada; Toyokazu Fukunaga; Kiyotaka Kawaguchi; Hiroaki Ito; Takefumi Nakamura; Shujiro Yazumi
        DIGESTIVE DISEASES AND SCIENCES, Jun. 2010, Peer-reviewed
      • Epidermal Growth Factor Receptor and Mutant p53 Expand an Esophageal Cellular Subpopulation Capable of Epithelial-to-Mesenchymal Transition through ZEB Transcription Factors
        Shinya Ohashi; Mitsuteru Natsuizaka; Gabrielle S. Wong; Carmen Z. Michaylira; Katharine D. Grugan; Douglas B. Stairs; Jiri Kalabis; Maria E. Vega; Ross A. Kalman; Momo Nakagawa; Andres J. Klein-Szanto; Meenhard Herlyn; J. Alan Diehl; Anil K. Rustgi; Hiroshi Nakagawa
        CANCER RESEARCH, May 2010, Peer-reviewed
      • Hypoxia activates the cyclooxygenase-2-prostaglandin E synthase axis
        James J. Lee; Mitsuteru Natsuizaka; Shinya Ohashi; Gabrielle S. Wong; Munenori Takaoka; Carmen Z. Michaylira; Daniela Budo; John W. Tobias; Michiyuki Kanai; Yasuhiro Shirakawa; Yoshio Naomoto; Andres J. P. Klein-Szanto; Volker H. Haase; Hiroshi Nakagawa
        CARCINOGENESIS, Mar. 2010, Peer-reviewed
      • Perforation of the Sigmoid Colon by an Ingested Fish Bone
        Masaki Watanabe; Tadayuki Kou; Yoshihiro Nishikawa; Yojiro Sakuma; Nanae Kumagai; Yayoi Oda; Yoko Kato; Yasushi Kudo; Atsushi Yamauchi; Yasushi Sugiura; Shinya Ohashi; Masanori Asada; Toyokazu Fukunaga; Kiyotaka Kawaguchi; Shujiro Yazumi
        INTERNAL MEDICINE, 2010, Peer-reviewed
      • Cellular biometrics in the postgenomics era
        Doug B. Stairs; Shinya Ohashi; Hiroshi Nakagawa
        CANCER BIOLOGY & THERAPY, Nov. 2008, Peer-reviewed
      • Cross-primed CD8(+) cytotoxic T cells induce severe helicobacter-associated gastritis in the absence of CD4(+) T cells
        Toshiro Fukui; Akiyoshi Nishio; Kazuichi Okazaki; Katsuhiro Kasahara; Kazuyuki Saga; Junya Tanaka; Norimitsu Uza; Satoru Ueno; Masahiro Kido; Shinya Ohashi; Masanori Asada; Hiroshi Nakase; Norihiko Watanabe; Tsutomu Chiba
        HELICOBACTER, Oct. 2007, Peer-reviewed
      • Essential role of Peyer's patches in the development of Helicobacter-induced gastritis
        Keiichi Kiriya; Norihiko Watanabe; Akiyoshi Nishio; Kazuichi Okazaki; Masahiro Kido; Kazuyuki Saga; Junya Tanaka; Takuji Akamatsu; Shinya Ohashi; Masanori Asada; Toshiro Fukui; Tsutomu Chiba
        INTERNATIONAL IMMUNOLOGY, Apr. 2007, Peer-reviewed
      • Essential role of Peyer's patches in the development of helicobacter-induced gastritis
        Norihiko Watanabe; Keiichi Kiriya; Akiyoshi Nishio; Masahiro Kido; Kazuyuki Saga; Jurrya Tanaka; Takuji Akamatsu; Shinya Ohashi; Masanori Asada; Toshiro Fukui; Kazuichi Okazaki; Tsutomu Chiba
        GASTROENTEROLOGY, Apr. 2007, Peer-reviewed
      • Identification of a novel autoantibody against pancreatic secretory trypsin inhibitor in patients with autoimmune pancreatitis
        Asada Masanori; Nishio Akiyoshi; Uchida Kazushige; Kido Masahiro; Ueno Satoru; Uza Norimitsu; Kiriya Keiichi; Inoue Satoko; Kitamura Hiroshi; Ohashi Shinya; Tamaki Hiroyuki; Fukui Toshiro; Matsuura Minoru; Kawasaki Kimio; Nishi Toshiki; Watanabe Norihiko; Nakase Hiroshi; Chiba Tsutomu; Okazaki Kazuichi
        Suizo, 2007
      • Human thioredoxin-1 ameliorates experimental murine colitis in association with suppressed macrophage inhibitory factor production
        Hiroyuki Tamaki; Hajime Nakamura; Akiyoshi Nishio; Hiroshi Nakase; Satoru Ueno; Norimitsu Uza; Masahiro Kido; Satoko Inoue; Sakae Mikami; Masanori Asada; Keiichi Kiriya; Hiroshi Kitamura; Shinya Ohashi; Toshiro Fukui; Kimio Kawasaki; Minoru Matsuura; Yasuyuki Ishii; Kazuichi Okazaki; Junji Yodoi; Tsutomu Chiba
        GASTROENTEROLOGY, Oct. 2006, Peer-reviewed
      • Gastrointestinal: Epidermal metaplasia of the esophagus
        T. Fukui; T. Sakurai; S. Miyamoto; S. Ueno; M. Kido; K. Kiriya; S. Inoue; S. Ohashi; A. Nishio; T. Chiba
        JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Oct. 2006, Peer-reviewed
      • Overexpression of redox-active protein thioredoxin-1 prevents development of chronic pancreatitis in mice
        Shinya Ohashi; Akiyoshi Nishio; Hajime Nakamura; Masanori Asada; Hiroyuki Tamaki; Kimio Kawasaki; Toshiro Fukui; Junji Yodoi; Tsutomu Chiba
        ANTIOXIDANTS & REDOX SIGNALING, Sep. 2006, Peer-reviewed
      • Gastrointestinal: MALT lymphoma of the terminal ileum
        S. Ohashi; S. Yazumi; N. Watanabe; S. Matsumoto; T. Fukui; A. Nishio; T. Chiba
        JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Sep. 2006, Peer-reviewed
      • Identification of a novel autoantibody against pancreatic secretory trypsin inhibitor in patients with autoimmune pancreatitis
        Masanori Asada; Akiyoshi Nishio; Kazushige Uchida; Masahiro Kido; Satoru Ueno; Norimitsu Uza; Keiichi Kiriya; Satoko Inoue; Hiroshi Kitamura; Shinya Ohashi; Hiroyuki Tamaki; Toshiro Fukui; Minoru Matsuura; Kimio Kawasaki; Toshiki Nishi; Norihiko Watanabe; Hiroshi Nakase; Tsutomu Chiba; Kazuichi Okazaki
        PANCREAS, Jul. 2006, Peer-reviewed
      • Gastric mucosal hyperplasia via upregulation of gastrin induced by persistent activation of gastric innate immunity in major histocompatibility complex class II deficient mice
        T Fukui; A Nishio; K Okazaki; N Uza; S Ueno; M Kido; S Inoue; H Kitamura; K Kiriya; S Ohashi; M Asada; H Tamaki; M Matsuura; K Kawasaki; K Suzuki; K Uchida; H Fukui; H Nakase; N Watanabe; T Chiba
        GUT, May 2006, Peer-reviewed
      • Clinical significance of serum thioredoxin 1 levels in patients with acute pancreatitis
        Shinya Ohashi; Akiyoshi Nishio; Hajime Nakamura; Masahiro Kido; Keiichi Kiriya; Masanori Asada; Hiroyuki Tamaki; Toshiro Fukui; Kimio Kawasaki; Norihiko Watanabe; Junji Yodoi; Kazuichi Okazaki; Tsutomu Chiba
        PANCREAS, Apr. 2006, Peer-reviewed
      • Protective roles of redox-active protein thioredoxin-1 for severe acute pancreatitis
        S Ohashi; A Nishio; H Nakamura; M Kido; S Ueno; N Uza; S Inoue; H Kitamura; K Kiriya; M Asada; H Tamaki; M Matsuura; K Kawasaki; T Fukui; N Watanabe; H Nakase; J Yodoi; K Okazaki; T Chiba
        AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, Apr. 2006, Peer-reviewed
      • Acute cerebral infarction during combination chemotherapy with S-1 and cisplatin for a young patient with a mucin-producing adenocarcinoma of the stomach
        Shinya Ohashi; Shujiro Yazumi; Akiyoshi Nishio; Toshiro Fukui; Masanori Asada; Tsutomu Chiba
        INTERNAL MEDICINE, 2006, Peer-reviewed
      • Helicobacter felis-induced gastritis was suppressed in mice overexpressing thioredoxin-1
        K Kawasaki; A Nishio; H Nakamura; K Uchida; T Fukui; M Ohana; H Yoshizawa; S Ohashi; H Tamaki; M Matsuura; M Asada; T Nishi; H Nakase; S Toyokuni; WR Liu; J Yodoi; K Okazaki; T Chiba
        LABORATORY INVESTIGATION, Sep. 2005, Peer-reviewed
      • Therapeutic effects of rectal administration of basic fibroblast growth factor on experimental murine colitis
        M Matsuura; K Okazaki; A Nishio; H Nakase; H Tamaki; K Uchida; T Nishi; M Asada; K Kawasaki; T Fukui; H Yoshizawa; S Ohashi; S Inoue; C Kawanami; H Hiai; Y Tabata; T Chiba
        GASTROENTEROLOGY, Apr. 2005, Peer-reviewed
      • A case of autoimmune pancreatitis associated with sclerosing cholangitis, retroperitoneal fibrosis and Sjogren's syndrome
        T Fukui; K Okazaki; H Yoshizawa; S Ohashi; H Tamaki; K Kawasaki; M Matsuura; M Asada; H Nakase; Y Nakashima; A Nishio; T Chiba
        PANCREATOLOGY, 2005, Peer-reviewed
      • 実験的急性膵炎モデルにおけるチオレドキシンの防御作用についての検討
        大橋 真也; 西尾 彰功; 井上 聡子; 北村 浩; 桐谷 景一; 吉澤 はづき; 浅田 全範; 玉置 敬之; 松浦 稔; 川崎 公男; 福井 寿朗; 仲瀬 裕志; 中村 肇; 千葉 勉
        日本消化器病学会雑誌, Sep. 2004

      Misc.

      • レザフィリンPDTにおける光線過敏症対策
        玉置将司; 大橋真也; 廣橋研志郎; 吉岡正博; 天沼裕介; 武藤 学
        日本レーザー医学会誌, 2019
      • 気管食科領域におけるアルコール発がん-広域発がん現象-
        玉置将司; 大橋真也; 武藤 学
        日本気管食道科学会会報(日気食会報), 2018
      • 慢性的なアルコール・タバコの暴露が関与する食道発癌メカニズム
        横山 顕礼; 垣内 伸之; 鈴木 啓道; 吉里 哲一; 青木 恒一; 竹内 康英; 天沼 裕介; 西川 佳孝; 大橋 真也; 青山 育雄; 堀松 高博; 宮本 心一; 角田 茂; 南口 早智子; 武藤 学; 小川 誠司
        日本消化器病学会雑誌, Sep. 2017
      • エタノール投与後マウスにおける食道組織内DNAアダクト(N2ethylidene2’dG)の動態
        馬場希一郎; 大橋真也; 天沼裕介; 廣橋研志郎; 松原淳一; 松田知成; 武藤学
        日本食道学会学術集会抄録集(CD-ROM), Jun. 2017
      • リンパ節転移による隣接臓器浸潤(T4LN)食道癌についての検討
        野村 基雄; 坂中 克行; 角田 茂; 天沼 裕介; 尾崎 由直; 大橋 真也; 宮本 心一; 藤井 康太; 石田 祐一; 武藤 学
        日本食道学会学術集会プログラム・抄録集, Jun. 2017
      • リンパ節転移による隣接臓器浸潤(T4LN)食道癌についての検討
        野村 基雄; 坂中 克行; 角田 茂; 天沼 裕介; 尾崎 由直; 大橋 真也; 宮本 心一; 藤井 康太; 石田 祐一; 武藤 学
        日本食道学会学術集会プログラム・抄録集, Jun. 2017
      • ANTI-TUMOR EFFECT OF THERACURMIN (R), HIGHLY BIOAVAILABLE CURCUMIN, FOR ESOPHAGEAL SQUAMOUS CELL CARCINOMA
        Ayaka Mizumoto; Shinya Ohashi; Kenshiro Hirohashi; Yukie Nakai; Junichi Matsubara; Masashi Kanai; Manabu Muto
        GASTROENTEROLOGY, Apr. 2017
      • 3D ORGANOIDS REVEAL THE AUTOPHAGY-CD44 CELL AXIS IN ESOPHAGEAL CANCER THERAPY RESISTANCE
        Kelly A. Whelan; Koji Tanaka; Takashi Kijima; Shinya Ohashi; Prasanna Chandramouleeswaran; Medha Sharma; Yoshiaki Kita; Andres Klein-Szanto; Gregory G. Ginsberg; Manabu Muto; Shoji Natsugoe; Anil K. Rustgi; Hiroshi Nakagawa
        GASTROENTEROLOGY, Apr. 2017
      • PROTECTIVE EFFECTS OF ALDA-1, AN ALDH2 ACTIVATOR, AGAINST ALCOHOL-DERIVED DNA DAMAGE IN THE ESOPHAGUS OF HUMAN ALDH2*2 (GLU504LYS) KNOCK-IN MICE
        Kenshiro Hirohashi; Shinya Ohashi; Yukie Nakai; Ayaka Mizumoto; Masahiro Yoshioka; Tomonari Matsuda; Manabu Muto
        GASTROENTEROLOGY, Apr. 2017
      • トラスツズマブを用いて胃癌のHER2タンパク過剰発現を検出する新規検査キットの開発(Novel Ex Vivo Examination Kit using Trastuzumab to Detect HER2 Protein Expression)
        吉岡 正博; 大橋 真也; 宮本 心一; 武藤 学
        日本胃癌学会総会記事, Mar. 2017
      • トラスツズマブを用いて胃癌のHER2タンパク過剰発現を検出する新規検査キットの開発(Novel Ex Vivo Examination Kit using Trastuzumab to Detect HER2 Protein Expression)
        吉岡 正博; 大橋 真也; 宮本 心一; 武藤 学
        日本胃癌学会総会記事, Mar. 2017
      • EGFR inhibitors exert different effects on epithelial-like and mesenchymal-like esophageal squamous carcinoma cells
        Masahiro Yoshioka; Shinya Ohashi; Tomomi Ida; Yukie Nakai; Osamu Kikuchi; Yusuke Amanuma; Jun'ichi Matsubara; Atsushi Yamada; Shin'ichi Miyamoto; Manabu Muto
        JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Nov. 2016
      • 上皮様、間葉様の食道扁平上皮がんに対するEGFR阻害剤による分化誘導効果
        吉岡 正博; 大橋 真也; 菊池 理; 玉置 将司; 松原 淳一; 森 由希子; 宮本 心一; 武藤 学
        日本癌学会総会記事, Oct. 2016
      • アセトアルデヒドによる食道上皮細胞傷害におけるp53依存性細胞老化の役割
        天沼 裕介; 大橋 真也; 廣橋 研志郎; 松田 知成; 武藤 学
        日本食道学会学術集会プログラム・抄録集, Jul. 2016
      • ALDH2 Inactivation Due to Cyanamide Exacerbates DNA Damage in the Esophagus of Mice That Consume Alcohol
        Kenshiro Hirohashi; Shinya Ohashi; Yusuke Amanuma; Yukie Nakai; Shin'ichi Miyamoto; Tomonari Matsuda; Manabu Muto
        GASTROENTEROLOGY, Apr. 2016
      • p53-Dependent Senescence Suppresses the Proliferation of Esophageal Epithelial Cells With Acetaldehyde-Derived DNA Damage
        Kenshiro Hirohashi; Shinya Ohashi; Yusuke Amanuma; Yukie Nakai; Shin'ichi Miyamoto; Hiroshi Nakagawa; Tomonari Matsuda; Manabu Muto
        GASTROENTEROLOGY, Apr. 2016
      • Establishment of a 5-fluorouracil-resistant esophageal squamous cell carcinoma cells with dihydropyrimidine dehydrogenase gene amplification
        Osamu Kikuchi; Kiichiro Baba; Shinya Ohashi; Manabu Muto
        CANCER RESEARCH, Feb. 2016
      • 臨床工学の視点から見た内視鏡治療チームにおけるレーザー機器管理
        樋口 浩和; 堀松 高博; 大橋 真也; 武藤 学
        日本レーザー医学会誌, Sep. 2015
      • 食道癌に対する内視鏡的PDT治療における追加照射の安全性に関する検討
        大橋 真也; 堀松 高博; 武藤 学
        日本レーザー医学会誌, Sep. 2015
      • Notch3-mediated squamous cell differentiation shows anti-tumor effect on esophageal squamous cell carcinoma as well as reduces its resistance to 5-Fluorouracil
        Osamu Kikuchi; Shinya Ohashi; Yukie Nakai; Yusuke Amanuma; Masahiro Yoshioka; Shin'ichi Miyamoto; Mitsuteru Natsuizaka; Hiroshi Nakagawa; Tsutomu Chiba; Manabu Muto
        CANCER RESEARCH, Aug. 2015
      • 【消化器癌におけるレーザー光を用いた診断・治療】 PDTのメカニズム…とくに食道癌細胞株におけるアポトーシスについて
        大橋 真也; 武藤 学
        G.I.Research, Aug. 2015
      • Notch3過剰発現による食道扁平上皮分化誘導は腫瘍造成能及び5FU抵抗性を抑制する
        菊池 理; 大橋 真也; 天沼 裕介; 横山 顕礼; 宮本 心一; 松本 繁巳; 武藤 学
        日本食道学会学術集会プログラム・抄録集, Jul. 2015
      • Utilization of Mathematical software for problem-solving in Math. class (Study of Mathematical Software and Its Effective Use for Mathematics Education)
        Ohashi Shinya
        RIMS Kokyuroku, Jun. 2015
      • EGFR Inhibition Promotes Differentiation of Esophageal Squamous Cancer Cells Through Notch Signaling Pathway
        Masahiro Yoshioka; Shinya Ohashi; Osamu Kikuchi; Yusuke Amanuma; Tomomi Ida; Yukie Nakai; Hiroshi Nakagawa; Tsutomu Chiba; Manabu Muto
        GASTROENTEROLOGY, Apr. 2015
      • ALDH2 and Autophagy May Cooperate to Alleviate Acetaldehyde-Mediated DNA Damage and Cytotoxicity in Fission Yeast and Esophageal Epithelial Cells
        Koji Tanaka; Kelly A. Whelan; Chiaki Noguchi; Jasmine D. Peake; Grant Grothusen; Vinesh Anandarajan; Yusuke Amanuma; Shinya Ohashi; Tsutomu Chiba; Manabu Muto; Eishi Noguchi; Hiroshi Nakagawa
        GASTROENTEROLOGY, Apr. 2015
      • Alcohol Induces ALDH2 As a Novel Cytoprotective Mechanism to Suppress Acetaldehyde-Derived DNA Adduct Formation in Esophageal Epithelial Cells
        Yusuke Amanuma; Shinya Ohashi; Osamu Kikuchi; Yukie Nakai; Shin-ichi Miyamoto; Koji Tanaka; Kelly A. Whelan; Hiroshi Nakagawa; Tsutomu Chiba; Tomonari Matsuda; Manabu Muto
        GASTROENTEROLOGY, Apr. 2015
      • 難治性癌に対する根治を目指した内視鏡医療開発(産学連携を通して)
        武藤 学; 佐野 寧; 堀松 高博; 大橋 真也; 矢野 友規
        日本医学会総会会誌, Apr. 2015
      • REVIEW & PREVIEW アルコール摂取と食道癌
        廣橋 研志郎; 大橋 真也; 天沼 裕介; 武藤 学
        Medicina, Mar. 2015
      • Acetaldehyde/ethanol breath test for identifying people at high risk of upper aerodigestive tract cancer
        Ikuo Aoyama; Mihoko Tsurumaki; Yukie Nakai; Shinya Ohashi; Manabu Muto
        JOURNAL OF CLINICAL ONCOLOGY, Jan. 2015
      • TGF-beta in tumor microenvironment changes a switch of Notch1-mediated signaling to maintain cancer stem-like cells in esophageal squamous cell carcinoma
        Mitsuteru Natsuizaka; Shingo Kagawa; Kelly Whelan; Shinya Ohashi; Shunsuke Ohnishi; Goki Suda; Naoya Sakamoto; Anil K. Rustgi; Hiroshi Nakagawa
        CANCER RESEARCH, Jan. 2015
      • EGFR-lytic hybrid peptideの食道扁平上皮癌に対するin vitroでの有効性と安全性(Cytotoxicity and safety of EGFR-lytic hybrid peptide against esophageal squamous cell carcinoma in vitro)
        菊池 理; 大橋 真也; 堀部 智久; 河野 雅之; 武藤 学; 川上 浩司
        日本癌学会総会記事, Sep. 2014
      • Cytotoxicity and safety of EGFR-lytic hybrid peptide against esophageal squamous cell carcinoma in vitro (EGFR-lytic hybrid peptideの食道扁平上皮癌に対するin vitroでの有効性と安全性)
        Osamu Kikuchi; Shinya Ohashi; Tomohisa Horibe; Masayuki Kohno; Manabu Muto; Koji Kawakami
        「第73回日本癌学会学術集会」 2014年9月25日-27日, 横浜, Sep. 2014
      • 多施設型医師主導治験の体制構築と実施ー食道癌化学放射線療法(CRT)後の救済光線力学療法(PDT)の開発ー
        笠井宏委; 伊藤達也; 大橋真也; 猪原登志子; 山本倫生; 多田春江; 矢野友規; 武藤学
        第12回日本臨床腫瘍学会学術集会, Jul. 2014
      • DPDの高発現を伴った5-FU耐性食道扁平上皮癌細胞株の樹立
        菊池 理; 大橋 真也; 中井 由起恵; 天沼 裕介; 江副 康正; 宮本 心一; 武藤 学
        日本食道学会学術集会プログラム・抄録集, Jul. 2014
      • 食道上皮におけるALDH2発現誘導がアセトアルデヒドに起因する食道上皮傷害を制御する
        大橋 真也; 天沼 裕介; 鶴巻 美穂子; 中井 由起恵; 菊池 理; 宮本 心一; 千葉 勉; 松田 知成; 武藤 学
        日本食道学会学術集会プログラム・抄録集, Jul. 2014
      • 呼気を利用した食道癌のリスク判別法の開発
        青山 育雄; 武藤 学; 鶴巻 美穂子; 中井 由起恵; 江副 康正; 森田 周子; 堀松 高博; 大橋 真也; 横山 顕礼; 宮本 心一
        日本食道学会学術集会プログラム・抄録集, Jul. 2014
      • Autophagy Regulates Esophageal Cancer Stem Cell Phenotypic Plasticity by Targeting Mitochondria and Oxidative Stress
        Kelly A. Whelan; Shingo Kagawa; Andy Guo; Mitsuteru Natsuizaka; Hideaki Kinugasa; Shinya Ohashi; Yoshiaki Kita; Shoji Natsugoe; Seiji Naganuma; Andres J. Klein-Szanto; Ravi K. Amaravadi; Anil K. Rustgi; Hiroshi Nakagawa
        GASTROENTEROLOGY, May 2014
      • Induction of Aldehyde Dehydrogenase-2 (Aldh2) Expression in Esophageal Epithelial Cells Suppresses the Acetaldehyde-Mediated DNA Damage
        Yusuke Amanuma; Shinya Ohashi; Mihoko Tsurumaki; Yukie Nakai; Shin-ichi Miyamoto; Tsutomu Chiba; Hiroshi Nakagawa; Tomonari Matsuda; Manabu Muto
        GASTROENTEROLOGY, May 2014
      • Pivotal Cytotoxic Activity of EGFR-Lytic Hybrid Peptide Against 5-Fluorouracil-Resistant Esophageal Squamous Cell Carcinoma In Vitro
        Osamu Kikuchi; Shinya Ohashi; Tomohisa Horibe; Masayuki Kohno; Manabu Muto; Koji Kawakami
        GASTROENTEROLOGY, May 2014
      • 頭頸部・食道領域におけるfield cancerization メカニズム解明に挑む
        武藤 学; 天沼 祐介; 大橋 真也
        日本気管食道科学会会報, Apr. 2014
      • 消化管癌の分子病態学に関する進歩 食道扁平上皮におけるアルコール関連発癌機序の解明
        天沼 裕介; 大橋 真也; 武藤 学
        日本消化器病学会雑誌, Mar. 2014
      • アセトアルデヒドによる食道発がん機序の解明
        AMANUMA YUSUKE; OHASHI SHIN'YA; TSURUMAKI MIHOKO; MATSUDA TOMONARI; MUTO MANABU
        日本消化管学会総会学術集会プログラム・抄録集, 2014
      • 5-FU耐性食道扁平上皮癌細胞株の確立(Establishment of a novel 5-fluorouracil-resistant tumorigenic esophageal squamous cell carcinoma cell line)
        菊池 理; 大橋 真也; 栗山 大輔; 宮本 心一; 千葉 勉; 武藤 学
        日本癌学会総会記事, Oct. 2013
      • 5FU耐性食道癌細胞株に対するタラポルフィンを用いた光線力学療法の効果(Photodynamic therapy with talaporfin sodium in fluorouracil-resistant esophageal squamous cell carcinoma cells)
        栗山 大輔; 大橋 真也; 中井 由紀恵; 鶴巻 美穂子; 菊池 理; 江副 康正; 宮本 心一; 千葉 勉; 武藤 学
        日本癌学会総会記事, Oct. 2013
      • 食道扁平上皮で誘導されるALDH2はアセトアルデヒドによる細胞老化を制御する
        天沼 裕介; 大橋 真也; 宮本 心一; 千葉 勉; 武藤 学
        日本食道学会学術集会プログラム・抄録集, Jun. 2013
      • Aldehyde Dehydrogenase-2 Regulates Esophageal Epithelial Cell Senescence Checkpoint Functions Activated by an Alcohol Metabolite
        Yusuke Amanuma; Shinya Ohashi; Mihoko Tsurumaki; Osamu Kikuchi; Daisuke Kuriyama; Yukie Nakai; Takeshi Setoyama; Shinichi Miyamoto; Tsunehiro Oyama; Tsutomu Chiba; Manabu Muto
        GASTROENTEROLOGY, May 2013
      • Photodynamic Therapy Induces Apoptosis via Reactive Oxygen Species in Fluorouracil-Resistant Esophageal Squamous Cell Carcinoma Cells
        Shinya Ohashi; Mihoko Tsurumaki; Osamu Kikuchi; Daisuke Kuriyama; Yusuke Amanuma; Yukie Nakai; Takeshi Setoyama; Shinichi Miyamoto; Tsutomu Chiba; Manabu Muto
        GASTROENTEROLOGY, May 2013
      • Insulin-Like Growth Factor Binding Protein-3 Regulates Esophageal Tumor Initiating Capability via a Novel Insulin-Like Growth Factor-Independent Antioxidant Activity
        Hideaki Kinugasa; Mitsuteru Natsuizaka; Shingo Kagawa; Kelly A. Whelan; Harry Subramanian; Sanders Chang; Shinya Ohashi; Seiji Naganuma; J. Alan Diehl; Phyllis A. Gimotty; Andres J. Klein-Szanto; Meenhard Herlyn; Hiroshi Nakagawa
        GASTROENTEROLOGY, May 2013
      • Regulation of Chemotherapy Resistance Through Epithelial-Mesenchymal Transition by Zinc Finger E-Box-Binding Proteins
        Shinya Ohashi; Seiji Naganuma; Mitsuteru Natsuizaka; Shingo Kagawa; Hideaki Kinugasa; Harry Subramanian; Naoko Taoka; Steffen Heeg; Shugo Ueda; Andres J. Klein-Szanto; Oliver G. Opitz; Shujiro Yazumi; Hiroshi Itoh; Hiroshi Nakagawa
        GASTROENTEROLOGY, May 2012
      • A Functional Interplay Between TGF-beta and Notch Signaling Determines Esophageal Cancer Cell Fates
        Mitsuteru Natsuizaka; Seiji Naganuma; Shingo Kagawa; Shinya Ohashi; Kelly A. Whelan; Sanders Chang; Andrew D. Rhim; Andres J. Klein-Szanto; J. Alan Diehl; Meenhard Herlyn; Hiroshi Nakagawa
        GASTROENTEROLOGY, May 2012
      • CD44 Defines Highly Plastic Esophageal Squamous Cancer Cells With Tumor Initiating Capabilities
        Mitsuteru Natsuizaka; Sanders Chang; Shingo Kagawa; Seiji Naganuma; Shinya Ohashi; Kelly A. Whelan; Gabrielle S. Wong; Maria E. Vega; Yizeng Yang; Phyllis A. Gimotty; J. Alan Diehl; Meenhard Herlyn; Hiroshi Nakagawa
        GASTROENTEROLOGY, May 2012
      • EGFR and Notch Determine Esophageal Cell Fates Through an Antagonistic Crosstalk
        Shinya Ohashi; Mitsuteru Natsuizaka; Momo Nakagawa; Ross A. Kalman; Sanders Chang; Maria E. Vega; Jiri Kalabis; Douglas B. Stairs; Andres J. Klein-Szanto; J. Alan Diehl; Meenhard Herlyn; Hiroshi Nakagawa
        GASTROENTEROLOGY, May 2011
      • IGFBP3 Suppresses Reactive Oxygen Species and Cellular Senescence Response to Facilitate TGF-beta-Mediated EMT
        Mitsuteru Natsuizaka; Shinya Ohashi; Azal Ahmadi; Sanders Chang; Kei Nakagawa; Gabrielle S. Wong; Nobuki Miyamoto; Katharine D. Grugan; Andres J. Klein-Szanto; Meenhard Herlyn; J. Alan Diehl; Hiroshi Nakagawa
        GASTROENTEROLOGY, May 2011
      • Notch regulates squamous differentiation, cell plasticity and tumor heterogeneity in esophageal carcinoma
        Mitsuteru Natsuizaka; Shinya Ohashi; Seiji Naganuma; Ross A. Kalman; Asami Ohyama; Ben Rhoades; Maria E. Vega; Douglas B. Stairs; Andres J. Klein-Szanto; J. Alan Diehl; Devraj Basu; Meenhard Herlyn; Warren S. Pear; Hiroshi Nakagawa
        CANCER RESEARCH, Apr. 2011
      • Fibroblast-secreted hepatocyte growth factor plays a functional role in esophageal squamous cell carcinoma invasion
        Katharine D. Grugan; Charles G. Miller; Yao Yao; Carmen Z. Michaylira; Shinya Ohashi; Andres J. Klein-Szanto; Alan Diehl; Meenhard Herlyn; May Han; Hiroshi Nakagawa; Anil K. Rustgi
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jun. 2010, Peer-reviewed
      • Synergism Between EGFR and Mutant p53 Facilitates Epithelial-Mesenchymal Transition By Negating Oncogene-Activated Cellular Senescence in Transformed Human Esophageal Cells
        Shinya Ohashi; Mitsuteru Natsuizaka; Carmen Z. Michaylira; Gabrielle Wong; Christie M. Gutierrez; Charles G. Miller; Hideki Harada; Jiri Kalabis; Katharine D. Grugan; Douglas B. Stairs; Anil K. Rustgi; Hiroshi Nakagawa
        GASTROENTEROLOGY, May 2009
      • Epithelial Reconstitution Reveals Regulation of Differentiation and Cell Fate Decisions Through a Novel Interplay Between the Notch Signaling and Essential Cancer Genes in Esophageal Carcinogenesis
        Shinya Ohashi; Momo Nakagawa; Mitsuteru Natsuizaka; Douglas B. Stairs; Katharine D. Grugan; Jiri Kalabis; Gabrielle Wong; Yizeng Yang; Andres J. Klein-Szanto; Meenhard Herlyn; Warren S. Pear; Jonathan P. Katz; Hiroshi Nakagawa
        GASTROENTEROLOGY, May 2009
      • Genetic Ablation of the Notch Signaling Promotes TGF-beta-Induced Epithelial-Mesenchymal Transition Involving Posttranscriptional Regulation of ZEB1 and ZEB2 By MicroRNA-200 Family Members
        Shinya Ohashi; Ross A. Kalman; Mitsuteru Natsuizaka; Katharine D. Grugan; Douglas B. Stairs; Jiri Kalabis; Claudia Andl; Yizeng Yang; Ben Rhoades; Warren S. Pear; Jonathan P. Katz; Hiroshi Nakagawa
        GASTROENTEROLOGY, May 2009
      • Essential role of Peyer's patches in the development of Helicobacter-induced gastritis
        N. Watanabe; K. Kiriya; A. Nishio; K. Okazaki; M. Kido; K. Saga; J. Tanaka; T. Akamatsu; S. Ohashi; M. Asada; T. Fukui; I. Chiba
        HELICOBACTER, Aug. 2007
      • The role of innate immunity in the pathogenesis of murine experimental model of autoimmune pancreatitis
        Masanori Asada; Akiyoshi Nishio; Keiichi Kiriya; Takuji Akamatsu; Kazuyuki Saga; Jyunya Tanaka; Masahiro Kido; Shinya Ohashi; Norihiko Watanabe; Tsutomu Chiba
        GASTROENTEROLOGY, Apr. 2007
      • Possibility of trefoil factor family 3 (TFF3) as a therapeutic agent for post-EMR gastric ulceration
        Shinya Ohashi; Michiyuki Kanai; Motohide Kimura; Eriko Hayashi; Arimichi Takabayashi
        GASTROENTEROLOGY, Apr. 2007
      • Pancreatic secretory trypsin inhibitor is a target antigen in experimental autoimmune pancreatitis in mice
        Masanori Asada; Akiyoshi Nishio; Keiichi Kiriya; Kazuyuki Saga; Jyunya Tanaka; Katsuhiro Kasahara; Masahiro Kido; Satoru Ueno; Normitsu Uza; Satoko Inoue; Hiroshi Kitamura; Shinya Ohashi; Toshiro Fukui; Minoru Matsuura; Norihiko Watanabe; Hiroshi Nakase; Kazuichi Okazaki; Tsutomu Chiba
        GASTROENTEROLOGY, Apr. 2006
      • Overexpression of thioredoxin-1 prevents cerulein-induced pancreatic fibrosis in mice
        Shinya Ohashi; Akiyoshi Nishio; Hajime Nakamura; Junji Yodoi; Tsutomu Chiba
        GASTROENTEROLOGY, Apr. 2006
      • Activation of Nf-kappab is critical for maintenance of the epithelial barrier function in inflammatory bowel disease
        S Inoue; H Nakase; S Ueno; N Uza; M Kido; H Kitamura; K Kiriya; S Oohashi; M Asada; K Kawasaki; H Tamaki; T Fukui; M Matsuura; A Nishio; T Chiba
        GASTROENTEROLOGY, Apr. 2005
      • Protective roles of thioredoxin-1 (TRX-1), a redox-regulating protein, in the experimental model of acute pancreatitis in mice and serum levels of TRX-1 as a biomarker for oxidative stress in patients with acute pancreatitis
        S Ohashi; A Nishio; H Nakamura; M Kido; S Ueno; N Uza; S Inoue; H Kitamura; K Kiriya; M Asada; H Tamaki; M Mutsuura; K Kawasaki; T Fukui; H Nakase; J Yodoi; T Chiba
        GASTROENTEROLOGY, Apr. 2005
      • Gastric mucosal hyperplasia via upregulation of gastrin induced by chronic activation of gastric innate immunity
        T Fukui; A Nishio; H Kitamura; S Inoue; K Kiriya; S Ohashi; H Yoshizawa; M Asada; M Matsuura; K Kawasaki; H Tamaki; H Nakase; K Okazaki; T Chiba
        GASTROENTEROLOGY, Apr. 2004
      • Thioredoxin-1 is a novel therapeutic molecule for inflammatory bowel disease
        H Tamaki; A Nishio; S Inoue; K Kiriya; H Kitamura; H Yoshizawa; S Ohashi; T Fukui; M Matsuura; K Kawasaki; H Nakase; H Nakamura; K Okazaki; J Yodoi; T Thiba
        GASTROENTEROLOGY, Apr. 2004
      • Prevalence of autoantibodies against pancreatic secretory trypsin inhibitor (PSTI) as a novel diagnostic marker for patients with autoimmune pancreatitis
        M Asada; A Nishio; K Uchida; H Kitamura; S Inoue; K Kiriya; S Ohashi; H Yoshizawa; H Tamaki; T Fukui; K Kawasaki; M Matsuura; H Nakase; K Okazaki; T Chiba
        GASTROENTEROLOGY, Apr. 2004
      • Overexpression of thioredoxin in transgenic mice prevents severe acute pancreatitis induced with caerulein and lipopolysaccharide
        S Ohashi; A Nishio; S Inoue; H Kitamura; K Kiriya; H Yoshizawa; M Asada; H Tamaki; M Matsuura; K Kawasaki; T Fukui; H Nakase; H Nakamura; J Yodoi; T Chiba
        GASTROENTEROLOGY, Apr. 2004
      • Clinical significance of magnifying endoscopy in the remission stage of ulcerative colitis
        M Matsuura; A Nishio; C Kawanami; H Nakase; H Tamaki; M Asada; K Kawasaki; T Fukui; H Yoshizawa; S Ohashi; S Inoue; K Kiriya; H Kitamura; K Okazaki; T Chiba
        GASTROENTEROLOGY, Apr. 2004
      • Therapeutic effects of basic fibroblast growth factor in dextran sulfate sodium-induced murine colitis
        M Matsuura; K Okazaki; Y Tabata; M Ohana; H Uchida; T Nishi; M Asada; K Kawasaki; T Fukui; H Tamaki; M Iwano; H Yoshizawa; S Ohashi; T Chiba
        GASTROENTEROLOGY, Apr. 2003
      • Involvement of Th1 type cytokines and chemokines in the induction of murine autoimmune pancreatitis
        K Uchida; K Okazaki; H Yoshizawa; S Ohashi; T Fukui; K Kawasaki; H Tamaki; M Matsuura; M Asada; M Iwano; M Ohana; T Chiba
        GASTROENTEROLOGY, Apr. 2003
      • Overexpression of thioredoxin-1 in transgenie mice prevents Helicobacter felis-induced gastritis
        K Kawasaki; K Okazaki; H Yoshizawa; S Oohashi; H Tamaki; T Fukui; M Matsuura; M Asada; T Nishi; K Uchida; M Iwano; M Ohana; T Chiba
        GASTROENTEROLOGY, Apr. 2003
      • Chronic activation of gastric innate immunity may induce gastric hypertrophic changes via upregulation of gastrin
        T Fukui; K Okazaki; M Ohana; K Uchida; T Nishi; M Iwano; M Asada; M Matsuura; K Kawasaki; H Tamaki; S Ohashi; H Yoshizawa; T Chiba
        GASTROENTEROLOGY, Apr. 2003
      • Mice overexpressing thioredoxin-1 have a decreased susceptibility to dextran sodium sulfate-induced colitis
        H Tamaki; K Okazaki; M Matsuura; M Ohana; M Iwano; K Uchida; T Nishi; M Asada; K Kawasaki; T Fukui; H Yoshizawa; S Ohashi; H Nakamura; T Chiba
        GASTROENTEROLOGY, Apr. 2003
      • Roles of myeloid dendritic cells in the development of helicobacter felis-induced gastritis in mice
        T Nishi; S Ohashi; H Yoshizawa; M Iwano; T Fukui; K Kawasaki; H Tamaki; M Matsuura; M Asada; K Uchida; M Ohana; K Okazaki; T Chiba
        GASTROENTEROLOGY, Apr. 2003
      • Analysis of clinical phenotypes of autoimmune pancreatitis with special reference to immunological markers
        K Okazaki; K Uchida; M Asada; H Yoshizawa; S Oohashi; T Chiba
        GASTROENTEROLOGY, Apr. 2003
      • ヒトマクロファージに対するMycobacterium paratuberculosisの感染と血中GST‐IS900抗体価の意義
        TAMAOKI TAKAYUKI; MATSUURA MINORU; YOSHIZAWA HAZUKI; OHASHI SHIN'YA; FUKUI TOSHIRO; KAWASAKI KIMIO; OKAZAKI KAZUICHI; CHIBA TSUTOMU
        日本消化器病学会雑誌, 20 Mar. 2003

      Books and Other Publications

      • PDTのメカニズムーとくに食道癌細胞株におけるアポトーシスについて
        大橋 真也; 武藤 学, Joint work
        G.I.Reserach, Aug. 2015, Not refereed
      • アルコール摂取と食道癌
        廣橋研志郎; 大橋 真也; 武藤 学, Joint work
        Medicina, Mar. 2015, Not refereed
      • 食道扁平上皮の分化と癌化はどこまでわかったか
        大橋真也; 夏井坂光輝; 長沼誠二; 中川裕
        分子消化器病 先端医学社, Dec. 2012, Not refereed

      External funds: Kakenhi

      • Establishment of innovative development scheme of anti-cancer antibody
        Grant-in-Aid for Challenging Research (Pioneering)
        Medium-sized Section 50:Oncology and related fields
        Kyoto University
        松田 知成
        From 30 Jul. 2020, To 31 Mar. 2023, Granted
        抗がん抗体;抗体配列進化
      • Synthetic lethality with FTD and CHK1 inhibitor for esophageal squamous cell carcinoma
        Grant-in-Aid for Scientific Research (C)
        Basic Section 53010:Gastroenterology-related
        Kyoto University
        大橋 真也
        From 01 Apr. 2019, To 31 Mar. 2022, Granted
        合成致死;トリフルリジン;CHK1阻害剤;DNA傷害;DNA修復;DNA修復応答;放射線感受性;DNA障害;Synthetic lethality;トリフルリジン(FTD);TAS-102;食道扁平上皮癌
      • Research on Biological and Clinical Significance of VUS in Cancer Clinical Sequencing
        Grant-in-Aid for Scientific Research (B)
        Basic Section 50020:Tumor diagnostics and therapeutics-related
        Kyoto University
        Manabu Muto
        From 01 Apr. 2018, To 31 Mar. 2021, Project Closed
        VUS;HER2;APC;大腸がん;アファチニブ;遺伝子変異;がんクリニカルシークエンス;actionability;がんゲノム;クリニカルシークエンス;データベース
      • Preventive effects of ALDH2 activator on esophageal carcinogenesis
        Grant-in-Aid for Scientific Research (C)
        Kyoto University
        Shinya Ohashi
        From 01 Apr. 2016, To 31 Mar. 2019, Project Closed
        食道癌;食道扁平上皮癌;アセトアルデヒド;発癌;ALDH2;ALDH2遺伝子多型;ALDH2活性化;Alda-1;ヒト変異型ALDH2ノックインマウス;ALDH2活性;DNAアダクト;食道がん;アルコール;ALDH2活性増強;癌;食道;発がん予防
      • Anti-tumor effects of EGFR inhibitors via cell differentiation on esophageal cancer cells
        Grant-in-Aid for Scientific Research (C)
        Kyoto University
        Shinya Ohashi
        From 01 Apr. 2013, To 31 Mar. 2016, Project Closed
        食道癌;EGFR阻害剤;分化誘導;EGFRシグナル阻害;上皮系癌細胞;間葉系癌細胞;治療抵抗性;食道扁平上皮癌;細胞分化;EGFR阻害;抗がん剤耐性
      • 内視鏡的粘膜切除後消化管粘膜欠損に対するITFの臨床応用
        Grant-in-Aid for Young Scientists (Start-up)
        Tazuke Kofukai Medical Research Institute
        大橋 真也
        Project Closed
        消化管の創傷治癒;消化管粘膜修復因子;トレフォイルファクター;内視鏡的粘膜切除;人工的潰瘍
      • Investigation of the possibility of Trefoil Factor Family as a therapeutics for post-EMR (endoscopic mucosal resection) gastric ulcer
        Grant-in-Aid for Scientific Research (B)
        The Tazuke Kofukai
        Michiyuki KANAI
        Project Closed
        消化器の創傷治癒;消化管粘膜修復因子;トレフォイルファクターファミリー;ITF;内視鏡的粘膜切除(EMR);人工的潰瘍;消化管の創傷治癒;人工潰瘍, Epithelial wound healing;promoter of epithelial repair;Trefoil factor family;Intestinal trefoil factor;Endoscopic mucosal resection;artificial gastric ulcer
      • トリフルリジンとWee1阻害による食道扁平上皮癌に対する新たな治療戦略の確立
        Grant-in-Aid for Scientific Research (C)
        Basic Section 53010:Gastroenterology-related
        Kyoto University
        大橋 真也
        From 01 Apr. 2022, To 31 Mar. 2025, Adopted

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