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Kanda, Takehiro
Institute for Life and Medical Sciences (LiMe) Assistant Professor
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Last Updated :2026/08/19
Basic Information
Email Address
Email Address
kanda.takehiro.4a
kyoto-u.ac.jp
Professional Memberships
Academic Degree
Academic Resume (Graduate Schools)
Academic Resume (Undergraduate School/Majors)
Research History
- From Apr. 2022, To PresentKyoto University, 医生物学研究所, 助教
- From Apr. 2019, To Mar. 2022Japan Society for the Promotion of Science, 特別研究員-DC1
- From Aug. 2021, To Nov. 2021Japan Society for the Promotion of Science, 若手研究者海外挑戦プログラム (Friedrich-Loeffler-Institute)
- From Apr. 2015, To Mar. 2018株式会社新日本科学, 安全性研究所, 研究員
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ORCID ID
J-Global ID
Researcher number
50964649
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list
Last Updated :2026/08/19
Research
Research Topics, Overview of the research
Research Topics
Virology
Research Interests
Research Areas
Papers
- Development of a strand-specific RT-qPCR assay for detecting and quantifying Borna disease virus RNAs in infected cellsTakehiro Kanda; Shigeki Hattori; Ryo Komorizono; Keizo TomonagaJournal of Virological Methods, May 2026, Peer-reviewed, Lead author
- Structure and function of the RNA polymerase complex of Borna disease virus, a nuclear-replicating non-segmented negative-strand RNA virusEric Gibbs; Minako Ogino; Takehiro Kanda; Dean Watkins; Kyle Whiddon; Keizo Tomonaga; Sudha Chakrapani; Tomoaki OginoNucleic Acids Research, Jan. 2026, Peer-reviewed, Lead author
- Distinct 5′ UTR Requirements for Translation of the Bicistronic X/P mRNA Among Avian OrthobornavirusesMeng‐Chi Wu; Takehiro Kanda; Ryo Komorizono; Madoka Sakai; Alexander Leacy; Leonardo Susta; Akiko Makino; Keizo TomonagaMicrobiology and Immunology, Dec. 2025, Peer-reviewed, Corresponding author
- 神経性下垂体の侵襲に起因する中枢性尿崩症が疑われたボルナウイルス感染ヨウム(Psittacus erithacus)の1例髙木 慎介; 中村 進一; 神田 雄大; 朝長 啓造鳥類臨床, Sep. 2025, Peer-reviewed
- Borna disease virus 2 maintains genomic polymorphisms by superinfection in persistently infected cellsTakehiro Kanda; Pauline Dianne Santos; Dirk Höper; Martin Beer; Dennis Rubbenstroth; Keizo TomonagaNpj Viruses, Apr. 2025, Peer-reviewed, Lead author
- A single amino acid substitution in the Borna disease virus glycoprotein enhances the infectivity titer of vesicular stomatitis virus pseudotyped virus by altering membrane fusion activityYusa Akiba; Hiromichi Matsugo; Takehiro Kanda; Modoka Sakai; Akiko Makino; Keizo TomonagaMicrobiology and Immunology, Sep. 2024, Peer-reviewed
- Reverse genetics of parrot bornavirus 4 reveals a unique splicing of the glycoprotein gene that affects viral propagationRyo Komorizono; Kan Fujino; Susanne Kessler; Solveig Runge; Takehiro Kanda; Masayuki Horie; Akiko Makino; Dennis Rubbenstroth; Keizo TomonagaJournal of Virology, Aug. 2023, Peer-reviewed
- Reverse Genetics and Artificial Replication Systems of Borna Disease Virus 1Takehiro Kanda; Keizo TomonagaViruses, Oct. 2022, Peer-reviewed, Lead author
- Exogenous expression of both matrix protein and glycoprotein facilitates infectious viral particle production of Borna disease virus 1Takehiro Kanda; Madoka Sakai; Akiko Makino; Keizo TomonagaJournal of General Virology, Jul. 2022, Peer-reviewed, Lead author
- The Borna Disease Virus 2 (BoDV-2) Nucleoprotein Is a Conspecific Protein That Enhances BoDV-1 RNA-Dependent RNA Polymerase Activity.Takehiro Kanda; Masayuki Horie; Yumiko Komatsu; Keizo TomonagaJournal of Virology, Oct. 2021, Peer-reviewed, Lead author
- Optimal Expression of the Envelope Glycoprotein of Orthobornaviruses Determines the Production of Mature Virus Particles.Madoka Sakai; Yoko Fujita; Ryo Komorizono; Takehiro Kanda; Yumiko Komatsu; Takeshi Noda; Keizo Tomonaga; Akiko MakinoJournal of virology, Dec. 2020, Peer-reviewed
- Silencing of the foot-and-mouth disease virus internal ribosomal entry site by targeting relatively conserved region among serotypes.Takafumi Matsui; Yoshio Handa; Takehiro Kanda; Kyoko Tsukiyama-KoharaVirus genes, Dec. 2019, Peer-reviewed
- Genetic characterization of an avian H4N6 influenza virus isolated from the Izumi plain, Japan.Kosuke Okuya; Norihiro Kanazawa; Takehiro Kanda; Masakazu Kuwahara; Aya Matsuu; Masayuki Horie; Tatsunori Masatani; Shigehisa Toda; Makoto OzawaMicrobiology and immunology, Nov. 2017, Peer-reviewed
- IRES-mediated translation of foot-and-mouth disease virus (FMDV) in cultured cells derived from FMDV-susceptible and -insusceptible animals.Takehiro Kanda; Makoto Ozawa; Kyoko Tsukiyama-KoharaBMC veterinary research, Mar. 2016, Peer-reviewed, Lead author
- Full genome sequences of torque teno sus virus strains that coinfected a pig with postweaning multisystemic wasting syndrome in Japan: implications for genetic diversity.Makoto Ozawa; Toshiko Kawabata; Kosuke Okuya; Kiori Nagano; Takehiro Kanda; Norihiro Kanazawa; Kyoko Tsukiyama-Kohara; Akira Taneno; Eisaburo DeguchiArchives of virology, Dec. 2015, Peer-reviewed
Presentations
- Toward deciphering the molecular mechanisms of Borna disease virus 1-associated encephalitisKyoto University Symposium for Microbiology and Immunology 2026（Kyoto）, Jan. 2026
- ボルナ病ウイルス1のウイルスRNAの転写複製を制御する分子メカニズムの解析第72回日本ウイルス学会学術集会（浜松）, Oct. 2025
- Back-priming regulates viral RNA synthesis efficiency of Borna disease virus 1Molecular Determinants of Zoonotic Viruses and Beyond International Symposium（Freiburg/Germany）, Feb. 2025
- ボルナ病ウイルス1感染細胞におけるアクセサリータンパク質Xの機能解析第71回日本ウイルス学会学術集会（愛知）, Nov. 2024
- ボルナ病ウイルスのゲノム複製機構に関する研究第9回関西ウイルスクラブ（兵庫）, Oct. 2024
- Back-priming: a unique RNA replication strategy of Borna disease virus 1The 30th East Asia Joint Symposium on Biomedical Research（Taipei/Taiwan）, Oct. 2024, Invited
- Borna disease virus 1 employs the back-priming strategy to regulate viral RNA synthesis efficiency during infection第22回あわじ感染と免疫国際フォーラム（京都）, Sep. 2024
- Back-priming: a unique RNA replication strategy of Borna disease virus 1第4回関西RNAクラブ（大阪）, Aug. 2024
- The 3’ additional and promoter sequences of Borna disease virus 1 genome coordinately regulate viral transcription and replication.第25回日本RNA学会学術集会（東京）, Jun. 2024
- The 3’ end overhang of Borna disease virus 1 genomic RNA: generation mechanism and its role in viral replicationInternational symposium on emerging RNA viruses（Marburg/Germany）, Dec. 2023
- Elongation of additional nucleotides at the 3’ end of Borna disease virus 1 genomic RNAs is initiated by the back-priming of the RNA-dependent RNA polymerase and regulates viral replication第70回日本ウイルス学会学術集会（宮城）, Sep. 2023
- Development of a reverse genetics system for Borna disease virus 2 unveils a unique strategy to maintain viral genetic diversity in the persistently infected cells第21回あわじ感染と免疫国際フォーラム（長野）, Sep. 2023
- Reverse genetics system of Orthobornaviruses and its applicationNational Taiwan University School of Veterinary Medicine Special Seminar（Taipei/Taiwan）, Dec. 2022, Invited
- Effect of back-priming on replication efficiency of Borna disease virusAmerican Society for Virology 39th Annual Meeting（Colorado/USA）, Jun. 2020
- Nucleoprotein and phosphoprotein of Borna disease virus 2 increase the rescue efficiency of recombinant Borna disease virus 1American Society for Virology 38th Annual Meeting（Minnesota/USA）, Jul. 2019
- ボルナ病ウイルスのゲノム末端配列とポリメラーゼ活性への影響第16回ウイルス学キャンプ（神奈川）, May 2019
- ボルナ病ウイルスのゲノム末端配列と転写複製効率の評価The 8th Negative Strand Virus-Japan Symposium（沖縄）, Jan. 2019
- Elucidating the transcription and replication mechanisms of Borna disease virus 2 for improvement of Borna disease virus vector system第66回日本ウイルス学会学術集会（京都）, Oct. 2018
- Establishment of a reverse genetics system for Borna disease virus 2第69回日本ウイルス学会学術集会（長崎）, Nov. 2022
- Unsteady elongation at 3’ terminal of genomic RNA determines replication efficiency of Borna disease virus 1第23回日本RNA学会学術集会（京都）, Jul. 2022
- Additional expression of the matrix protein and glycoprotein facilitates infectious virus production of Borna disease virus第68回日本ウイルス学会学術集会（兵庫）, Nov. 2021
- ボルナ病ウイルスXタンパク質がウイルス感染サイクルに与える影響の解明第164回日本獣医学会学術集会（北海道）, Sep. 2021
- Back-primingによるボルナ病ウイルスのゲノム3’末端配列の多様化とゲノム複製効率への影響The 9th Negative Strand Virus-Japan Symposium（沖縄）, Jan. 2020
- Effect of Borna disease virus genome termini sequences on viral replication and transcription第67回日本ウイルス学会学術集会（東京）, Oct. 2019
- 口蹄疫ウイルスのIRES依存性翻訳活性の評価第156回日本獣医学会学術集会（岐阜）, Sep. 2013
- 腸石による馬の腸閉塞の1例平成24年度日本産業動物獣医学会（宮崎）, Oct. 2012
Awards
External funds: Kakenhi
- Development of technology to regulate gene expression of episomal RNA virus vectorGrant-in-Aid for Research Activity Start-up0403:Biomedical engineering and related fieldsKyoto UniversityTakehiro KandaFrom 31 Aug. 2022, To 31 Mar. 2024, Project Closedウイルスベクター;アクセサリータンパク質;遺伝子発現制御;ボルナ病ウイルス;遺伝子細胞治療
- Elucidation of the pathogenic mechanisms of Borna disease virus 1Grant-in-Aid for Early-Career ScientistsBasic Section 42020:Veterinary medical science-relatedKyoto UniversityTakehiro KandaFrom 01 Apr. 2023, To 31 Mar. 2025, Project Closedボルナ病ウイルス;RNA修飾;ボルナ病ウイルス1;病原性メカニズム
- ボルナ病ウイルス1型による脳炎に関与するT細胞サブセットの解明と治療標的の探索Grant-in-Aid for Early-Career ScientistsBasic Section 49060:Virology-relatedKyoto University神田 雄大From 01 Apr. 2025, To 31 Mar. 2027, Grantedボルナ病ウイルス;ウイルス性脳炎;神経免疫;T細胞サブセット
