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Kanda, Takehiro
Institute for Life and Medical Sciences (LiMe) Assistant Professor
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Last Updated :2025/05/26
Basic Information
Email Address
Email Address
kanda.takehiro.4a
kyoto-u.ac.jp
Professional Memberships
Academic Degree
Academic Resume (Graduate Schools)
Academic Resume (Undergraduate School/Majors)
Research History
- From Apr. 2022, To PresentKyoto University, 医生物学研究所, 助教
- From Apr. 2019, To Mar. 2022Japan Society for the Promotion of Science, 特別研究員（DC1）
- From Aug. 2021, To Nov. 2021Japan Society for the Promotion of Science, 若手研究者海外挑戦プログラム
- From Apr. 2015, To Mar. 2018株式会社新日本科学, 安全性研究所, 研究員
ID,URL
ORCID ID
J-Global ID
Researcher number
50964649
researchmap URL
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Last Updated :2025/05/26
Research
Research Topics, Overview of the research
Research Topics
Virology
Research Interests
Research Areas
Papers
- Borna disease virus 2 maintains genomic polymorphisms by superinfection in persistently infected cellsTakehiro Kanda; Pauline Dianne Santos; Dirk Höper; Martin Beer; Dennis Rubbenstroth; Keizo Tomonaganpj Viruses, 17 Apr. 2025, Peer-reviewed, Lead author
- A single amino acid substitution in the Borna disease virus glycoprotein enhances the infectivity titer of vesicular stomatitis virus pseudotyped virus by altering membrane fusion activityYusa Akiba; Hiromichi Matsugo; Takehiro Kanda; Modoka Sakai; Akiko Makino; Keizo TomonagaMicrobiology and Immunology, 23 Sep. 2024, Peer-reviewed
- Reverse genetics of parrot bornavirus 4 reveals a unique splicing of the glycoprotein gene that affects viral propagationRyo Komorizono; Kan Fujino; Susanne Kessler; Solveig Runge; Takehiro Kanda; Masayuki Horie; Akiko Makino; Dennis Rubbenstroth; Keizo TomonagaJournal of Virology, 31 Aug. 2023, Peer-reviewed
- Reverse Genetics and Artificial Replication Systems of Borna Disease Virus 1Takehiro Kanda; Keizo TomonagaViruses, 12 Oct. 2022, Peer-reviewed, Lead author
- Exogenous expression of both matrix protein and glycoprotein facilitates infectious viral particle production of Borna disease virus 1Takehiro Kanda; Madoka Sakai; Akiko Makino; Keizo TomonagaJournal of General Virology, 12 Jul. 2022, Peer-reviewed, Lead author
- The Borna Disease Virus 2 (BoDV-2) Nucleoprotein Is a Conspecific Protein That Enhances BoDV-1 RNA-Dependent RNA Polymerase Activity.Takehiro Kanda; Masayuki Horie; Yumiko Komatsu; Keizo TomonagaJournal of Virology, 13 Oct. 2021, Peer-reviewed, Lead author
- Optimal Expression of the Envelope Glycoprotein of Orthobornaviruses Determines the Production of Mature Virus Particles.Madoka Sakai; Yoko Fujita; Ryo Komorizono; Takehiro Kanda; Yumiko Komatsu; Takeshi Noda; Keizo Tomonaga; Akiko MakinoJournal of virology, 02 Dec. 2020, Peer-reviewed
- Silencing of the foot-and-mouth disease virus internal ribosomal entry site by targeting relatively conserved region among serotypes.Takafumi Matsui; Yoshio Handa; Takehiro Kanda; Kyoko Tsukiyama-KoharaVirus genes, Dec. 2019, Peer-reviewed
- Genetic characterization of an avian H4N6 influenza virus isolated from the Izumi plain, Japan.Kosuke Okuya; Norihiro Kanazawa; Takehiro Kanda; Masakazu Kuwahara; Aya Matsuu; Masayuki Horie; Tatsunori Masatani; Shigehisa Toda; Makoto OzawaMicrobiology and immunology, Nov. 2017, Peer-reviewed
- IRES-mediated translation of foot-and-mouth disease virus (FMDV) in cultured cells derived from FMDV-susceptible and -insusceptible animals.Takehiro Kanda; Makoto Ozawa; Kyoko Tsukiyama-KoharaBMC veterinary research, 31 Mar. 2016, Peer-reviewed, Lead author
- Full genome sequences of torque teno sus virus strains that coinfected a pig with postweaning multisystemic wasting syndrome in Japan: implications for genetic diversity.Makoto Ozawa; Toshiko Kawabata; Kosuke Okuya; Kiori Nagano; Takehiro Kanda; Norihiro Kanazawa; Kyoko Tsukiyama-Kohara; Akira Taneno; Eisaburo DeguchiArchives of virology, Dec. 2015, Peer-reviewed
Presentations
- Back-priming regulates viral RNA synthesis efficiency of Borna disease virus 1Molecular Determinants of Zoonotic Viruses and Beyond International Symposium（Freiburg/Germany）, Feb. 2025
- ボルナ病ウイルス1感染細胞におけるアクセサリータンパク質Xの機能解析第71回日本ウイルス学会学術集会（愛知）, Nov. 2024
- ボルナ病ウイルスのゲノム複製機構に関する研究第9回関西ウイルスクラブ（兵庫）, Oct. 2024
- Back-priming: a unique RNA replication strategy of Borna disease virus 1The 30th East Asia Joint Symposium on Biomedical Research（Taipei/Taiwan）, Oct. 2024, Invited
- Borna disease virus 1 employs the back-priming strategy to regulate viral RNA synthesis efficiency during infection第22回あわじ感染と免疫国際フォーラム（京都）, Sep. 2024
- Back-priming: a unique RNA replication strategy of Borna disease virus 1第4回関西RNAクラブ（大阪）, Aug. 2024
- The 3’ additional and promoter sequences of Borna disease virus 1 genome coordinately regulate viral transcription and replication.第25回日本RNA学会学術集会（東京）, Jun. 2024
- The 3’ end overhang of Borna disease virus 1 genomic RNA: generation mechanism and its role in viral replicationInternational symposium on emerging RNA viruses（Marburg/Germany）, Dec. 2023
- Elongation of additional nucleotides at the 3’ end of Borna disease virus 1 genomic RNAs is initiated by the back-priming of the RNA-dependent RNA polymerase and regulates viral replication第70回日本ウイルス学会学術集会（宮城）, Sep. 2023
- Development of a reverse genetics system for Borna disease virus 2 unveils a unique strategy to maintain viral genetic diversity in the persistently infected cells第21回あわじ感染と免疫国際フォーラム（長野）, Sep. 2023
- Reverse genetics system of Orthobornaviruses and its applicationNational Taiwan University School of Veterinary Medicine Special Seminar（Taipei/Taiwan）, Dec. 2022, Invited
- Effect of back-priming on replication efficiency of Borna disease virusAmerican Society for Virology 39th Annual Meeting（Colorado/USA）, Jun. 2020
- Nucleoprotein and phosphoprotein of Borna disease virus 2 increase the rescue efficiency of recombinant Borna disease virus 1American Society for Virology 38th Annual Meeting（Minnesota/USA）, Jul. 2019
- ボルナ病ウイルスのゲノム末端配列とポリメラーゼ活性への影響第16回ウイルス学キャンプ（神奈川）, May 2019
- ボルナ病ウイルスのゲノム末端配列と転写複製効率の評価The 8th Negative Strand Virus-Japan Symposium（沖縄）, Jan. 2019
- Elucidating the transcription and replication mechanisms of Borna disease virus 2 for improvement of Borna disease virus vector system第66回日本ウイルス学会学術集会（京都）, Oct. 2018
- Establishment of a reverse genetics system for Borna disease virus 2第69回日本ウイルス学会学術集会（長崎）, Nov. 2022
- Unsteady elongation at 3’ terminal of genomic RNA determines replication efficiency of Borna disease virus 1第23回日本RNA学会学術集会（京都）, Jul. 2022
- Additional expression of the matrix protein and glycoprotein facilitates infectious virus production of Borna disease virus第68回日本ウイルス学会学術集会（兵庫）, Nov. 2021
- ボルナ病ウイルスXタンパク質がウイルス感染サイクルに与える影響の解明第164回日本獣医学会学術集会（北海道）, Sep. 2021
- Back-primingによるボルナ病ウイルスのゲノム3’末端配列の多様化とゲノム複製効率への影響The 9th Negative Strand Virus-Japan Symposium（沖縄）, Jan. 2020
- Effect of Borna disease virus genome termini sequences on viral replication and transcription第67回日本ウイルス学会学術集会（東京）, Oct. 2019
- 口蹄疫ウイルスのIRES依存性翻訳活性の評価第156回日本獣医学会学術集会（岐阜）, Sep. 2013
- 腸石による馬の腸閉塞の1例平成24年度日本産業動物獣医学会（宮崎）, Oct. 2012
Awards
External funds: Kakenhi
- Development of technology to regulate gene expression of episomal RNA virus vectorGrant-in-Aid for Research Activity Start-up0403:Biomedical engineering and related fieldsKyoto UniversityTakehiro KandaFrom 31 Aug. 2022, To 31 Mar. 2024, Project Closedウイルスベクター;アクセサリータンパク質;遺伝子発現制御;ボルナ病ウイルス;遺伝子細胞治療
- ボルナ病ウイルス１型の病原性メカニズムの解明Grant-in-Aid for Early-Career ScientistsBasic Section 42020:Veterinary medical science-relatedKyoto University神田 雄大From 01 Apr. 2023, To 31 Mar. 2025, Grantedボルナ病ウイルス;RNA修飾;病原性メカニズム
- ボルナ病ウイルス1型による脳炎に関与するT細胞サブセットの解明と治療標的の探索Grant-in-Aid for Early-Career ScientistsBasic Section 49060:Virology-relatedKyoto University神田 雄大From 01 Apr. 2025, To 31 Mar. 2027, Adopted
