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Nonomura, Keiko
Institute for Life and Medical Sciences (LiMe) Professor
list
Last Updated :2026/08/19
Basic Information
Affiliated programs (koza)
Concurrent Affiliation
Email Address
Email Address
nonomura.keiko.3e
kyoto-u.ac.jp
Academic Degree
Academic Resume (Undergraduate School/Majors)
Research History
- From Apr. 2024, To PresentKyoto University, 医生物学研究所, 教授
- From Jan. 2022, To Mar. 2024Tokyo Institute of Technology, School of Life Science and Technology, 准教授
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ORCID ID
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researchmap URL
list
Last Updated :2026/08/19
Research
Research Areas
Papers
- Biomechanical regulation of Ca 2+ dynamics during muscle stem cell activationKotaro Hirano; Yudai Ishikawa; Norio Motohashi; Yujiro Kobata; Hiroto Watanabe; Mao Sasaki; Takuya Yokoyama; Yuto Yamada; Kanako Takakura; Akira Murakami; Masaki Tsuchiya; Yusuke Ono; Keiko Nonomura; Yoshitsugu Aoki; Yuji Hara21 May 2026
- Baculovirus-mediated gene transfer enables functional expression of the PIEZO1 ion channel in isolated muscle satellite cells.Akira Murakami; Ayuno Masuda; Takumi Hirakawa; Riku Nakanishi; Kotaro Hirano; Masaki Tsuchiya; Keiko Nonomura; Yusuke Ono; Takashi Murayama; Yuji HaraJournal of cell science, 01 Apr. 2026
- Podocyte-specific deletion of mechanochannel Piezo1 exacerbates proteinuria and podocyte injury in mouse hypertensive nephropathy.Kaori Mikami; Takashi Nagase; Hisaki Kishino; Nobuhiro Nakamura; Yoshiro Suzuki; Hiroshi Fukuhara; Taiji Matsusaka; Keiko Nonomura; Miki NagaseHypertension research : official journal of the Japanese Society of Hypertension, Feb. 2026
- PIEZO1-dependent mode switch of neuronal migration in heterogeneous microenvironments in the developing brain.Naotaka Nakazawa; Gianluca Grenci; Yoshitaka Kameo; Noriko Takeda; Tsuyoshi Sawada; Junko Kurisu; Zhejing Zhang; Kenichi Toma; Taiji Adachi; Keiko Nonomura; Mineko KengakuCell reports, 25 Mar. 2025, Peer-reviewed
- The mechanosensitive ion channel PIEZO1 promotes satellite cell function in muscle regeneration.Kotaro Hirano; Masaki Tsuchiya; Akifumi Shiomi; Seiji Takabayashi; Miki Suzuki; Yudai Ishikawa; Yuya Kawano; Yutaka Takabayashi; Kaori Nishikawa; Kohjiro Nagao; Eiji Umemoto; Yasuo Kitajima; Yusuke Ono; Keiko Nonomura; Hirofumi Shintaku; Yasuo Mori; Masato Umeda; Yuji HaraLife science alliance, Feb. 2023, Peer-reviewed
- Piezo2 expression and its alteration by mechanical forces in mouse mesangial cells and renin-producing cells.Yuki Mochida; Koji Ochiai; Takashi Nagase; Keiko Nonomura; Yoshihiro Akimoto; Hiroshi Fukuhara; Tatsuo Sakai; George Matsumura; Yoshihiro Yamaguchi; Miki NagaseScientific reports, 10 Mar. 2022, Peer-reviewed
- Apoptosis is involved in maintaining the character of the midbrain and the diencephalon roof plate after neural tube closure.Yudai Matsumoto; Yoshifumi Yamaguchi; Misato Hamachi; Keiko Nonomura; Yukiko Muramatsu; Hiroki Yoshida; Masayuki MiuraDevelopmental biology, 01 Dec. 2020, Peer-reviewed
- Cell mechanosensing underlies homeostasis of multicellular systems.Keiko Nonomura; Hiroaki HirataBiophysics and physicobiology, 2020, Peer-reviewed, Lead author, Corresponding author
- Mechanically activated ion channel PIEZO1 is required for lymphatic valve formation.Nonomura K; Lukacs V; Sweet DT; Goddard LM; Kanie A; Whitwam T; Ranade SS; Fujimori T; Kahn ML; Patapoutian AProc Natl Acad Sci U S A., Dec. 2018, Peer-reviewed, Lead author, Corresponding author
- GPR68 Senses Flow and Is Essential for Vascular PhysiologyJie Xu; Jayanti Mathur; Emilie Vessières; Scott Hammack; Keiko Nonomura; Julie Favre; Linda Grimaud; Matt Petrus; Allain Francisco; Jingyuan Li; Van Lee; Fu-li Xiang; James K. Mainquist; Stuart M. Cahalan; Anthony P. Orth; John R. Walker; Shang Ma; Viktor Lukacs; Laura Bordone; Michael Bandell; Bryan Laffitte; Yan Xu; Shu Chien; Daniel Henrion; Ardem PatapoutianCell, 19 Apr. 2018, Peer-reviewed
- Piezo2 senses airway stretch and mediates lung inflation-induced apnoeaKeiko Nonomura; Seung-Hyun Woo; Rui B. Chang; Astrid Gillich; Zhaozhu Qiu; Allain G. Francisco; Sanjeev S. Ranade; Stephen D. Liberles; Ardem PatapoutianNATURE, Jan. 2017, Peer-reviewed, Lead author
- Contribution of apoptosis in cranial neural tube closure indicated by mouse embryo live imagingYoshifumi Yamaguchi; Naomi Shinotsuka; Keiko Nonomura; Masayuki MiuraNew Principles in Developmental Processes, 01 Nov. 2014, Peer-reviewed
- Local apoptosis modulates early mammalian brain development through the elimination of morphogen-producing cells.Keiko Nonomura; Yoshifumi Yamaguchi; Misato Hamachi; Masato Koike; Yasuo Uchiyama; Kenichi Nakazato; Atsushi Mochizuki; Asako Sakaue-Sawano; Atsushi Miyawaki; Hiroki Yoshida; Keisuke Kuida; Masayuki MiuraDevelopmental cell, 23 Dec. 2013, Peer-reviewed, Lead author
- Live imaging of apoptosis in a novel transgenic mouse highlights its role in neural tube closureYoshifumi Yamaguchi; Naomi Shinotsuka; Keiko Nonomura; Kiwamu Takemoto; Keisuke Kuida; Hiroki Yosida; Masayuki MiuraJOURNAL OF CELL BIOLOGY, Dec. 2011, Peer-reviewed
- Simultaneous expression of different transgenes in neurons and glia by combining in utero electroporation with the Tol2 transposon-mediated gene transfer systemAyako Yoshida; Yoshifumi Yamaguchi; Keiko Nonomura; Koichi Kawakami; Yoshiko Takahashi; Masayuki MiuraGENES TO CELLS, May 2010, Peer-reviewed
Misc.
- 呼吸パターンはメカノセンサータンパク質Piezo2により調節される野々村 恵子実験医学, May 2017, Invited
- カチオンチャネルPiezo2は肺の体積センサーとして呼吸を制御する野々村 恵子ライフサイエンス新着論文レビュー, Jan. 2017, Invited
- 局所において起こるアポトーシスはモルフォゲンを産生する細胞の除去を介し哺乳類の発生の初期における脳の形成を制御する野々村 恵子; 山口 良文; 三浦 正幸ライフサイエンス新着論文レビュー, Jan. 2014, Invited
- Contribution of apoptosis to early brain morphogenesis; not restricting overall cell number, but ensuring the completion of neural tube closureKeiko Nonomura; Yoshifumi Yamaguchi; Hiroki Yoshida; Keisuke Kuida; Masayuki MiuraNEUROSCIENCE RESEARCH, 2011
- Live-imaging analysis of apoptosis and caspase activation reveals that apoptosis is a facilitator of the neural tube closureYoshifumi Yamaguchi; Naomi Shinotsuka; Keiko Nonomura; Masayuki MiuraDEVELOPMENTAL BIOLOGY, Aug. 2010
- Apoptosis is dispensable for the control of cell number during early brain morphogenesisKeiko Nonomura; Yoshifumi Yamaguchi; Hiroki Yoshida; Masayuki MiuraDEVELOPMENTAL BIOLOGY, Aug. 2010
- Targeted expression of transgene in glial cells by the combination of the Tol2 transposon system and in utero electroporationAyako Yoshida; Yoshifumi Yamaguchi; Keiko Nonomura; Koichi Kawakami; Yoshiko Takahashi; Masayuki MiuraNEUROSCIENCE RESEARCH, 2009
- Persistent expression of electroporated transgenes in progenitor cells and late-born cells in developing mouse telencephalonKeiko Nonomura; Ayako Yoshida; Yoshifumi Yamaguchi; Koichi Kawakami; Yoshiko Takahashi; Masayuki MiuraNEUROSCIENCE RESEARCH, 2008
Presentations
- PIEZOメカノセンサーチャネルが司る生体臓器の機能制御野々村 恵子第27回日本正常圧水頭症学会学術集会, 14 Feb. 2026, Invited
- PIEZO メカノセンサーチャネルの発見物語:皮膚触覚と呼吸パターン調節への寄与について野々村 恵子第47回日本呼吸療法医学会学術集会, 31 Aug. 2025, Invited
- 細胞膜のメカノセンシング生理学野々村 恵子日本化学学会第105回春季年会, Mar. 2025, Invited
- PIEZO機械受容チャネルの発見がもたらしたメカノセンシング生理学研究の世界（2021年ノーベル生理学医学賞に寄せて）野々村 恵子第46回日本神経科学学会大会, 02 Aug. 2023, Invited
- Mechanically activated ion channel PIEZO1 is required for lymphatic/venous valve formation野々村 恵子CVMW2022 心血管代謝学会, 16 Dec. 2022, Invited
- 生体の多彩なメカノセンシングを担うPIEZOチャネル (2021年ノーベル生理学・医学賞に寄せて)野々村 恵子第23回計測自動制御学会システムインテグレーション部門講演会（SI2022), 14 Dec. 2022, Invited
- 機械受容感覚(皮膚触覚・固有感覚・肺の伸展受容)を司るPIEZOメカノセンサーチャネル野々村 恵子第５５回日本味と匂学会大会, Sep. 2021, Invited
- Mechanically activated ion channel PIEZO1 is required for lymphatic valve formation野々村 恵子第126回 日本解剖学会総会・全国学術集会, 28 Mar. 2021, Invited
- メカノセンサーチャネルPiezo1はリンパ管の弁の形成に寄与する野々村 恵子第61回日本脈管学会総会, 13 Oct. 2020, Invited
- Spacially defned mechanotransduction via PIEZO1 involved in lymphatic valve formation野々村 恵子第58回 生物物理学会年会, 17 Sep. 2020
- リンパ管の弁形成におけるメカノセンサーチャネルPiezo1の寄与野々村 恵子第44回リンパ学会総会, 11 Sep. 2020
- PIEZOチャネルから探る生体内のメカノセンシング野々村 恵子第42回分子生物学会, Dec. 2019, Invited
- PIEZO mechanically activated channels in the respiratory and lymphatic systemsKeiko Nonomura内藤コンファレンス, Oct. 2019
- PIEZOチャネルに支えられた生体のメカノセンシング〜皮膚触覚とリンパ管の弁形成〜野々村 恵子第58回日本生体医工学会大会, Jun. 2019, Invited
- Mechanically activated channel PIEZO1 is required for lymphatic valve formationNonomura Keiko第52回日本発生生物学会年会, May 2019
- メカノセンサーチャネルPiezo1/2の哺乳類生体内での役割野々村 恵子第56回生物物理学会年会, Sep. 2018
- Mechanosensor channel Piezo1 in the morphogenesis of the lymphatic vasculatureKeiko Nonomura日本生化学会大会,シンポジウム 組織再編成のメカニクス - 細胞接着制御から機械刺激応答, Sep. 2018, Invited
- Physiological importance of Piezo mechanically activated ion channel in sensory neurons, the vasculature system and red blood cellsNonomura Keiko第40回日本血栓止血学会学術集会 SPCシンポジウム, Jun. 2018, Invited
- Contribution of mechanosensor channel Piezo1 to the lymphatic vascular developmentNonomura Keiko第70回細胞生物学会第51回日本発生生物学会合同大会, May 2018
- Breathing patterns regulated by mechano-sensing channel Piezo2Nonomura Keiko第95回日本生理学会大会、センシングチャネル研究へのセンシブルなアプローチ：生理学から薬理学へ, Mar. 2018, Invited
- Piezo2-mediated mehcanosensation in the control of breathing patternsNonomura Keiko2017年度生命科学系学会合同年次大会(ConBio2017),シンポジウム 呼吸器生命科学のランドスケープ-分子生物学・発生生物学・再生医学の融合, Dec. 2017, Invited
- Mechanotransducer channel Piezo2 regulates respiration at birth in the adultNonomura Keiko第50回日本発生生物学会大会, May 2017
- Role of Piezo ion channels is mechanosensationNonomura KeikoThe Calcium and Cell Function Conference, FASEB Meeting, 2016
- Mechanosensation by Piezo ion channelsNonomura KeikoNeuroscince 2016, Annual Meeting of Society for neuroscience, 2016
Books and Other Publications
Awards
- 23 Jun. 2010Best Presentation Award
- 30 Jul. 2009優秀発表賞
- 04 Mar. 2017最優秀発表賞
- 01 Apr. 2024令和６年度科学技術分野の文部科学大臣表彰若手科学者賞
External funds: Kakenhi
- 脳脊髄液産生組織における機械受容のライフステージおよび日内における変動の解析Grant-in-Aid for Challenging Research (Exploratory)Medium-sized Section 44:Biology at cellular to organismal levels, and related fieldsKyoto University田中 恵子; 野々村恵子From 26 Jun. 2026, To 31 Mar. 2029, Grantedメカノセンサー;脳
- The role of mechanically activated channel PIEZO in the homeostasis of brain fluidGrant-in-Aid for Scientific Research (B)Basic Section 47030:Pharmaceutical hygiene and biochemistry-relatedKyoto University;Tokyo Institute of Technology;National Institute for Basic BiologyKeiko NonomuraFrom 01 Apr. 2024, To 31 Mar. 2025, Project Closedメカノセンサー分子;脳発生;遺伝子改変マウス;メカノセンサーチャネル;脳;メカノセンサー;脳の液性ダイナミクス;PIEZO;メカノセンシング;脳脊髄液;液性成分
- Analysis of mechanosensory dyamics in the tissue producing cerebro-spinal flulidGrant-in-Aid for Transformative Research Areas (B)Transformative Research Areas, Section (III)Tokyo Institute of TechnologyKeiko NonomuraFrom 23 Aug. 2021, To 31 Mar. 2024, Project Closedメカノセンサーチャネル;脳;イメージング;神経科学;発生生物学;脳脊髄液;ライブイメージング;脳発生;メカノセンサー;ex vivo;メカノセンシング;圧力
- Promotion of Pressio-NeuroscienceGrant-in-Aid for Transformative Research Areas (B)Transformative Research Areas, Section (III)Tokyo Institute of Technology;National Institute for Basic BiologyKeiko NonomuraFrom 23 Aug. 2021, To 31 Mar. 2024, Project Closedメカノセンシング;脳神経科学;総括班;冠シンポジウム;領域会議;研究者ネットワーク;冠ワークショップ;研究会
- Pressio neuro-brain science: principle for brain function development through compressive stresses under physiological or pathological conditionGrant-in-Aid for Transformative Research Areas (B)From 23 Aug. 2021, To 31 Mar. 2024, Project Closed
- Regulation of tissue morphogenesis by mechanosensor channel Piezo1Grant-in-Aid for Research Activity Start-upNational Institute for Basic BiologyKeiko TanakaFrom 25 Aug. 2017, To 31 Mar. 2018, Project ClosedPiezo;機械的な力;組織形態形成;メカノセンシング;Piezo チャネル
list
Last Updated :2026/08/19
Education
Teaching subject(s)
- From 01 Apr. 2026, To 31 Mar. 2027Introduction to Biology and Life ScienceN484, Spring, Institute for Liberal Arts and Sciences, 2
- From 01 Apr. 2026, To 31 Mar. 2027Advanced Course in Studies on Signal Transduction1029, Spring, Graduate School of Biostudies, 1
- From 01 Apr. 2026, To 31 Mar. 2027Advanced Experiments in Systemic Life Sciences5013, Spring, Graduate School of Biostudies, 4
- From 01 Apr. 2026, To 31 Mar. 2027Advanced Experiments in Systemic Life Sciences5013, Fall, Graduate School of Biostudies, 4
- From 01 Apr. 2026, To 31 Mar. 2027Experimental Course and Seminar A2006, Spring, Graduate School of Biostudies, 5
- From 01 Apr. 2026, To 31 Mar. 2027Experimental Course and Seminar A2006, Fall, Graduate School of Biostudies, 5
- From 01 Apr. 2026, To 31 Mar. 2027Experimental Course and Seminar C2008, Fall, Graduate School of Biostudies, 5
- From 01 Apr. 2026, To 31 Mar. 2027Experimental Course and Seminar B2007, Spring, Graduate School of Biostudies, 5
- From 01 Apr. 2026, To 31 Mar. 2027Experimental Course and Seminar B2007, Fall, Graduate School of Biostudies, 5
- From 01 Apr. 2026, To 31 Mar. 2027Experimental Course and Seminar D2009, Spring, Graduate School of Biostudies, 5
- From 01 Apr. 2026, To 31 Mar. 2027Experimental Course and Seminar D2009, Fall, Graduate School of Biostudies, 5
- From 01 Apr. 2026, To 31 Mar. 2027Experimental Course and Seminar C2008, Spring, Graduate School of Biostudies, 5
- From 01 Apr. 2025, To 31 Mar. 2026ILAS SeminarZ001, Spring, Institute for Liberal Arts and Sciences, 2
- From 01 Apr. 2025, To 31 Mar. 2026Advanced Course in Studies on Signal Transduction1029, Spring, Graduate School of Biostudies, 1
- From 01 Apr. 2025, To 31 Mar. 2026Advanced Experiments in Systemic Life Sciences5013, Spring, Graduate School of Biostudies, 4
- From 01 Apr. 2025, To 31 Mar. 2026Advanced Experiments in Systemic Life Sciences5013, Fall, Graduate School of Biostudies, 4
- From 01 Apr. 2025, To 31 Mar. 2026Experimental Course and Seminar D2009, Spring, Graduate School of Biostudies, 5
- From 01 Apr. 2025, To 31 Mar. 2026Experimental Course and Seminar D2009, Fall, Graduate School of Biostudies, 5
- From 01 Apr. 2025, To 31 Mar. 2026Experimental Course and Seminar B2007, Fall, Graduate School of Biostudies, 5
- From 01 Apr. 2025, To 31 Mar. 2026Experimental Course and Seminar A2006, Spring, Graduate School of Biostudies, 5
- From 01 Apr. 2025, To 31 Mar. 2026Experimental Course and Seminar A2006, Fall, Graduate School of Biostudies, 5
- From 01 Apr. 2025, To 31 Mar. 2026Experimental Course and Seminar C2008, Spring, Graduate School of Biostudies, 5
- From 01 Apr. 2025, To 31 Mar. 2026Experimental Course and Seminar C2008, Fall, Graduate School of Biostudies, 5
- From 01 Apr. 2025, To 31 Mar. 2026Experimental Course and Seminar B2007, Spring, Graduate School of Biostudies, 5
- From 01 Apr. 2024, To 31 Mar. 2025Advanced Experiments in Systemic Life Sciences5013, Fall, Graduate School of Biostudies, 4
- From 01 Apr. 2024, To 31 Mar. 2025Advanced Experiments in Systemic Life Sciences5013, Spring, Graduate School of Biostudies, 4
- From 01 Apr. 2024, To 31 Mar. 2025Experimental Course and Seminar A2006, Spring, Graduate School of Biostudies, 5
- From 01 Apr. 2024, To 31 Mar. 2025Experimental Course and Seminar A2006, Fall, Graduate School of Biostudies, 5
- From 01 Apr. 2024, To 31 Mar. 2025Experimental Course and Seminar C2008, Fall, Graduate School of Biostudies, 5
- From 01 Apr. 2024, To 31 Mar. 2025Experimental Course and Seminar B2007, Spring, Graduate School of Biostudies, 5
- From 01 Apr. 2024, To 31 Mar. 2025Experimental Course and Seminar B2007, Fall, Graduate School of Biostudies, 5
- From 01 Apr. 2024, To 31 Mar. 2025Experimental Course and Seminar C2008, Spring, Graduate School of Biostudies, 5
- From 01 Apr. 2024, To 31 Mar. 2025Experimental Course and Seminar D2009, Spring, Graduate School of Biostudies, 5
- From 01 Apr. 2024, To 31 Mar. 2025Experimental Course and Seminar D2009, Fall, Graduate School of Biostudies, 5
