Basic Information

Email Address

• Email Address

  uechi.hiroyuki.6pkyoto-u.ac.jp

Academic Degree

• 22 Mar. 2012

  東京大学修士（薬科学）
• 24 Mar. 2015

  東京大学博士（薬科学）

Academic Resume (Undergraduate School/Majors)

• 東京大学, 薬学部薬科学科, 卒業

Research History

• From Apr. 2025, To Present

  Kyoto University, Graduate School of Pharmaceutical Sciences, 准教授
• From Apr. 2023, To Mar. 2025

  Tohoku University, Frontier Research Institute for Interdisciplinary Sciences, 助教
• From May 2019, To Nov. 2023

  Max Planck Institute of Molecular Cell Biology and Genetics, Postdoc
• From Apr. 2017, To May 2019

  東北大学大学院生命科学研究科, 特任助教
• From Apr. 2015, To Mar. 2017

  理化学研究所 多細胞システム形成研究センター, 研究員

Profile

• Profile

  https://bsky.app/profile/hiro-cg5445.bsky.social

ID,URL

• ORCID ID

  0000-0002-7511-3558

• J-Global ID

  202201004254133120

• Researcher number

  50755452

• External link

  https://scholar.google.co.jp/citations?hl=ja&user=k9CBaZUAAAAJ&view_op=list_works&sortby=pubdate

researchmap URL

• https://researchmap.jp/hiroyuki_uechi

Research

Research Interests

• Intracellular phase separation

Research Areas

• Life sciences, Developmental biology
• Life sciences, Cell biology, Condensate Biology

Papers

• Quantitative In Vivo Imaging of ATP Dynamics in Drosophila Using the Ratiometric Biosensor QUEEN

  Yuhan Luo; Sayaka Sekine; Naoto Kasahara; Hiroyuki Uechi; Takafumi Toyohara; Takaaki Abe; Erina Kuranaga

  Development, Growth & Differentiation, Aug. 2026, Peer-reviewed

  
• A conserved motif tunes Sidekick condensate dynamics to control tricellular junction recruitment during epithelial remodeling

  Hiroyuki Uechi; Daxiao Sun; Yuki Saeki; Tetsuya Hiraiwa; Alf Honigmann; Anthony A. Hyman; Erina Kuranaga

  Cell Reports, May 2026, Peer-reviewed, Lead author, Corresponding author

  Access this paper :

  
• Small-molecule dissolution of stress granules by redox modulation benefits ALS models

  Hiroyuki Uechi; Sindhuja Sridharan; Jik Nijssen; Jessica Bilstein; Juan M. Iglesias-Artola; Satoshi Kishigami; Virginia Casablancas-Antras; Ina Poser; Eduardo J. Martinez; Edgar Boczek; Michael Wagner; Nadine Tomschke; António M. de Jesus Domingues; Arun Pal; Thom Doeleman; Sukhleen Kour; Eric Nathaniel Anderson; Frank Stein; Hyun O. Lee; Xiaojie Zhang; Anatol W. Fritsch; Marcus Jahnel; Julius Fürsch; Anastasia C. Murthy; Simon Alberti; Marc Bickle; Nicolas L. Fawzi; André Nadler; Della C. David; Udai B. Pandey; Andreas Hermann; Florian Stengel; Benjamin G. Davis; Andrew J. Baldwin; Mikhail M. Savitski; Anthony A. Hyman; Richard J. Wheeler

  Nature Chemical Biology, Oct. 2025, Peer-reviewed, Lead author

  
• Underlying mechanisms that ensure actomyosin‐mediated directional remodeling of cell–cell contacts for multicellular movement

  Hiroyuki Uechi; Erina Kuranaga

  BioEssays, 17 Mar. 2023, Peer-reviewed, Invited, Lead author

  
• Inhibition of negative feedback for persistent epithelial cell-cell junction contraction by p21-activated kinase 3.

  Hiroyuki Uechi; Kazuki Fukushima; Ryota Shirasawa; Sayaka Sekine; Erina Kuranaga

  Nature communications, 20 Jun. 2022, Peer-reviewed, Lead author

  
• The Tricellular Junction Protein Sidekick Regulates Vertex Dynamics to Promote Bicellular Junction Extension.

  Hiroyuki Uechi; Erina Kuranaga

  Developmental cell, 05 Aug. 2019, Peer-reviewed, Lead author

  
• Mechanisms of unusual collective cell movement lacking a free front edge in Drosophila.

  Hiroyuki Uechi; Erina Kuranaga

  Current opinion in genetics & development, Aug. 2018, Peer-reviewed, Invited, Lead author

  
• Ubiquitin-Binding Protein CG5445 Suppresses Aggregation and Cytotoxicity of Amyotrophic Lateral Sclerosis-Linked TDP-43 in Drosophila.

  Hiroyuki Uechi; Erina Kuranaga; Tomohiro Iriki; Kohei Takano; Shoshiro Hirayama; Masayuki Miura; Jun Hamazaki; Shigeo Murata

  Molecular and cellular biology, 01 Feb. 2018, Peer-reviewed, Lead author

  
• Mechanisms of collective cell movement lacking a leading or free front edge in vivo.

  Hiroyuki Uechi; Erina Kuranaga

  Cellular and molecular life sciences : CMLS, Aug. 2017, Peer-reviewed, Invited, Lead author

  
• Characterization of the testis-specific proteasome subunit α4s in mammals.

  Hiroyuki Uechi; Jun Hamazaki; Shigeo Murata

  The Journal of biological chemistry, 02 May 2014, Peer-reviewed, Lead author

  

Misc.

• 【細胞の社会学-細胞間で繰り広げられる協調と競争】細胞の競争と協調の数理モデル 上皮細胞の集団移動を可能にする細胞平面の運動と力学モデル

  上地 浩之; 倉永 英里奈

  生体の科学, Apr. 2016

  
• ショウジョウバエを用いたプロテアソーム遺伝学的相互作用因子の探索

  上地 浩之; 濱崎 純; 倉永 英里奈; 三浦 正幸; 村田 茂穂

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2010

  

Presentations

• 小分子によるストレス顆粒相分離の調節

  上地浩之

  第12回 日本筋学会学術集会, 31 Jul. 2026, Invited

  
• Sidekick condensation ensures protein accumulation to tricellular junctions for epithelial remodeling

  Hiroyuki Uechi

  International Symposium Physical Biology of Multicellular Dynamics, 12 Mar. 2026, Invited

  
• 非ドメイン領域を介した三細胞結合点の分子局在・機能発現

  上地浩之

  第4回タンパク質シンポジウム, 23 Jan. 2026, Invited

  
• 小分子を介した細胞質ストレス顆粒コンデンセーションの制御

  上地浩之

  第24回日本蛋白質科学会年会, 12 Jun. 2024, Invited

  
• Control of stress granule condensation by a small molecule

  Hiroyuki Uechi

  Mini-symposium “Frontiers in Regeneration: Protein Homeostasis in Degeneration and Regeneration of the Nervous System”, 29 Nov. 2022, Invited

  
• Dissecting molecular mechanisms of cell rearrangement for tissue morphogenesis

  Hiroyuki Uechi

  New Frontiers in Genetics, 04 Sep. 2022, Invited

  
• Regulation of intercellular junction growth by apical tricellular junctions

  Hiroyuki Uechi

  The Joint Annual Meeting of 70th JSCB and 51st JSDB, 05 Jun. 2018

  

External funds: Kakenhi

• 分子組成依存的な細胞膜上タンパク質相分離による細胞接着分布機構

  Grant-in-Aid for Transformative Research Areas (A)

  Transformative Research Areas, Section (III)

  Kyoto University

  上地 浩之

  From 01 Apr. 2026, To 31 Mar. 2028, Granted

  細胞内相分離

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-26H01629/
• 三細胞結合点を構成する分子実体の探索と機能解析

  Grant-in-Aid for Scientific Research (C)

  Basic Section 44010:Cell biology-related

  Tohoku University

  上地 浩之

  From 01 Apr. 2024, To 31 Mar. 2027, Granted

  三細胞結合;細胞接着分子;上皮形態形成

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K09448/
• 天然変性領域を介した膜貫通型細胞接着分子の動態・機能発現

  Grant-in-Aid for Transformative Research Areas (A)

  Transformative Research Areas, Section (III)

  Kyoto University;Tohoku University

  上地 浩之

  From 01 Apr. 2024, To 31 Mar. 2026, Granted

  細胞間接着;上皮形態形成;試験管内再構成;細胞内ドメイン;天然変性領域;細胞内相分離

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-24H01344/
• Physical-chemical basis of tricellular adherens junctions underpinning tissue morphogenesis

  Grant-in-Aid for Research Activity Start-up

  0702:Biology at cellular to organismal levels, and related fields

  Tohoku University

  Hiroyuki Uechi

  From 31 Aug. 2023, To 31 Mar. 2025, Project Closed

  上皮形態形成;三細胞結合点;細胞内相分離;三細胞結合;細胞接着分子

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K19361/
• Constructing optogenetic tools for spatiotemporal regulation of contractile forces in cells

  Grant-in-Aid for Early-Career Scientists

  Basic Section 44010:Cell biology-related

  Tohoku University

  Hiroyuki Uechi

  From 01 Apr. 2018, To 31 Mar. 2020, Project Closed

  光遺伝学;アクトミオシン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K14691/

Education

Teaching subject(s)

• From 01 Apr. 2026, To 31 Mar. 2027

  Pharmaceutical Laboratory Coaching Practice B

  8302, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2026, To 31 Mar. 2027

  Pharmaceutical Laboratory Coaching Practice A

  8301, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2026, To 31 Mar. 2027

  Research Proposal Writing Practice B

  8403, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2026, To 31 Mar. 2027

  Research Proposal Writing Practice A

  8402, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2026, To 31 Mar. 2027

  Seminar on Critical Reading of Scientific Papers B

  8405, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2026, To 31 Mar. 2027

  Seminar on Critical Reading of Scientific Papers A

  8404, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2026, To 31 Mar. 2027

  Pharmaceutical Health Science I (Health Chemistry)

  C212, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2026, To 31 Mar. 2027

  Pharmaceutical Health Science 1 (Health Chemistry)

  A212, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2026, To 31 Mar. 2027

  Medicinal Frontier Science Research C

  8408, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2026, To 31 Mar. 2027

  Medicinal Frontier Science Research B

  8407, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2026, To 31 Mar. 2027

  Medicinal Frontier Science Research A

  8406, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2026, To 31 Mar. 2027

  Pharmaceutical Laboratory IV : Biochemistry and Microbiology

  C906, Fall, Faculty of Pharmaceutical Sciences, 3
• From 01 Apr. 2025, To 31 Mar. 2026

  Research Proposal Writing Practice B

  8403, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  Research Proposal Writing Practice A

  8402, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  Pharmaceutical Laboratory Coaching Practice B

  8302, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  Pharmaceutical Laboratory Coaching Practice A

  8301, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  Seminar on Critical Reading of Scientific Papers B

  8405, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Seminar on Critical Reading of Scientific Papers A

  8404, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Medicinal Frontier Science Research A

  8406, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2025, To 31 Mar. 2026

  Medicinal Frontier Science Research C

  8408, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2025, To 31 Mar. 2026

  Medicinal Frontier Science Research B

  8407, Year-long, Graduate School of Pharmaceutical Sciences, 4

Administration

School management (title, position)

• From 01 Apr. 2026, To 31 Mar. 2027

  国際高等教育院 企画評価専門委員会 初修外国語部会