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Yoda, Akinori

Graduate School of Medicine Program-Specific Associate Professor

Yoda, Akinori
list
    Last Updated :2025/05/27

    Basic Information

    Professional Memberships

    • From Apr. 2020, To Present
      日本血液学会
    • 日本癌学会

    Academic Degree

    • M.S.(Tokyo University)
    • Ph.D. (Osaka University)

    Research History

    • Kobe University Graduate School of Medicine, Faculty of Medical Sciences, KOBE University Graduate School of Medicine, Assistant Professor

    Language of Instruction

    • English

    ID,URL

    researchmap URL

    list
      Last Updated :2025/05/27

      Research

      Research Topics, Overview of the research

      • Research Topics

        Novel therapeutic targets for leukemia

      • Overview of the research

        I am doing a research of drug development for cancer collaborating with biotech companies. In this project we employ the latest technologies including mouse in vivo models (knock-in/knock-out mice, patient-derived Xenograft (PDX) models and syngeneic mouse models for cancer immunotherapy) and OMICs analyses (DNA/RNA sequencing and proteomics analysis).

      Research Interests

      • キナーゼ
      • kinase

      Research Areas

      • Life sciences, Pathobiochemistry

      Papers

      • 単一細胞マルチオミクス解析によるクローン性造血の病態解明
        中川 正宏; 稲垣 良作; 黒田 隆; 南谷 泰仁; 趙 蘭英; 越智 陽太郎; 本村 公則; 昆 彩奈; 岡崎 幸治; 竹田 淳恵; 戚 星星; 依田 成玄; 垣内 伸之; 牧島 秀樹; 松田 秀一; 小川 誠司
        日本血液学会学術集会, Oct. 2024
      • クロマチンアクセシビリティ解析による急性骨髄性白血病の新規分子サブグループの同定
        越智 陽太郎; Markus Liew; 南谷 泰仁; 笠原 千嗣; 平本 展大; 兼村 信宏; 瀬崎 伸夫; 櫻田 麻希; 岩崎 惇; 諫田 淳也; 上田 恭典; 吉原 哲; Albin Osterroos; 本村 公則; 中川 正宏; 佐伯 龍之介; 福島 英人; 岡崎 幸治; 依田 成玄; 奥田 瑠璃花; Lanying Zhao; 白石 友一; 石川 隆之; 宮野 悟; 鈴木 洋; 高折 晃史; Soren Lehmann; 小川 誠司
        日本血液学会学術集会, Oct. 2024
      • 単一細胞マルチオミクス解析によるクローン性造血の病態解明(Distinct pathogenesis of clonal hematopoiesis revealed by single-cell multi-omics sequencing)
        中川 正宏; 稲垣 良作; 黒田 隆; 南谷 泰仁; 趙 蘭英; 越智 陽太郎; 本村 公則; 昆 彩奈; 岡崎 幸治; 竹田 淳恵; 威 星星; 依田 成玄; 垣内 伸之; 牧島 秀樹; 松田 秀一; 小川 誠司; 小川 誠司
        日本癌学会総会記事, Sep. 2024
      • AMLにおける分子病態と標的薬 単一細胞解析によって示唆されたAMLにおけるRAS経路変異クローンの役割(Single-cell DNA/RNA analysis revealed roles of RAS pathway mutated clones in AML)
        稲垣 良作; 中川 正宏; 南谷 泰仁; 戚 星星; 趙 蘭英; 竹田 淳恵; 依田 成玄; 昆 彩奈; 黒田 隆; 鶴見 寿; 牧島 秀樹; 小川 誠司
        日本血液学会学術集会, Sep. 2021
      • Germline DDX41 mutations define a unique subtype of myeloid neoplasms.
        Hideki Makishima; Ryunosuke Saiki; Yasuhito Nannya; Sophia Claire Korotev; Carmelo Gurnari; June Takeda; Yukihide Momozawa; Steven Best; Pramila Krishnamurthy; Tetsuichi Yoshizato; Yoshiko Atsuta; Yusuke Shiozawa; Yuka Iijima-Yamashita; Kenichi Yoshida; Yuichi Shiraishi; Yasunobu Nagata; Nobuyuki Kakiuchi; Makoto Onizuka; Kenichi Chiba; Hiroko Tanaka; Ayana Kon; Yotaro Ochi; Masahiro Marshall Nakagawa; Rurika Okuda; Takuto Mori; Akinori Yoda; Hidehiro Itonaga; Yasushi Miyazaki; Masashi Sanada; Takayuki Ishikawa; Shigeru Chiba; Hisashi Tsurumi; Senji Kasahara; Carsten Müller-Tidow; Akifumi Takaori-Kondo; Kazuma Ohyashiki; Toru Kiguchi; Fumihiko Matsuda; Joop H Jansen; Chantana Polprasert; Piers Blombery; Yoichiro Kamatani; Satoru Miyano; Luca Malcovati; Torsten Haferlach; Michiaki Kubo; Mario Cazzola; Austin G Kulasekararaj; Lucy A Godley; Jaroslaw P Maciejewski; Seishi Ogawa
        Blood, 02 Nov. 2022
      • Mouse models for developmental biology: Functional analysis of ror and Wnt signaling
        Isao Oishi; Akinori Yoda; Shuichi Kani; Yasuhiro Minami
        Genetically Engineered Mice Handbook, 19 Apr. 2016
      • 単一細胞マルチオミクス解析によるクローン造血の病態解明
        中川 正宏; 稲垣 良作; 黒田 隆; 南谷 泰仁; 趙 蘭英; 越智 陽太郎; 本村 公則; 竹田 淳恵; 戚 星星; 岡崎 幸治; 依田 成玄; 昆 彩奈; 垣内 伸之; 牧島 秀樹; 松田 秀一; 小川 誠司
        日本血液学会学術集会, Oct. 2023
      • クロマチンアクセシビリティ解析による急性骨髄性白血病のエピジェネティクス不均一性の解明
        越智 陽太郎; 南谷 泰仁; Liew-Littorin Markus; 笠原 千嗣; 平本 展大; 兼村 信宏; 瀬崎 伸夫; 櫻田 麻希; 岩崎 惇; 諫田 淳也; 上田 恭典; 吉原 哲; Osterroos Albin; 本村 公則; 中川 正宏; 佐伯 龍之介; 依田 成玄; 奥田 瑠璃花; 白石 友一; 石川 隆之; 宮野 悟; 高折 晃史; Lehmann Soren; 小川 誠司
        日本血液学会学術集会, Oct. 2023
      • がんのRNA異常の核心に迫る/The Nexus of RNA Dysregulation in Cancer 骨髄性腫瘍を標的とした新規スプライシング阻害剤CTX-712の開発(CTX-712, a novel splicing inhibitor targeting myeloid neoplasms)
        依田 成玄; 森下 大輔; 越智 陽太郎; 水谷 明生; 森 拓人; 竹田 淳恵; 戸崎 浩和; 佐藤 義彦; 牧島 秀樹; 中川 正宏; 南谷 泰仁; 小川 誠司
        日本癌学会総会記事, Sep. 2023
      • 骨髄系腫瘍におけるU2AF2体細胞突然変異によるミスプライシング(Mis-splicing due to somatic U2AF2 mutations in myeloid neoplasms)
        戚 星星; Yoshizato Tetsuichi; 南谷 泰仁; Nakagawa Masahiro M.; 昆 彩奈; 森 拓人; 依田 成玄; 越智 陽太郎; 竹田 淳恵; 佐伯 龍之介; 超 蘭英; Haferlach Torsten; Kanemura Nobuhiro; Kasahara Senji; 牧島 秀樹; 小川 誠司
        日本癌学会総会記事, Sep. 2023
      • 単一細胞マルチオミクス解析によるクローン性造血の病態解明(Distinct pathogenesis of clonal hematopoiesis revealed by single-cell multi-omics sequencing)
        中川 正宏; 南谷 泰仁; 超 蘭英; 越智 陽太郎; 竹田 淳恵; 戚 星星; 依田 成玄; 昆 彩奈; 垣内 伸之; 牧島 秀樹; 松田 秀一; 小川 誠司
        日本癌学会総会記事, Sep. 2023
      • 骨髄系腫瘍におけるU2AF2体細胞突然変異によるミススプライシング(Mis-splicing due to somatic U2AF2 mutations in myeloid neoplasms)
        戚 星星; Yoshizatoi Testuichi; 南谷 泰仁; Nakagawa Masahiro M.; 森 拓人; 昆 彩奈; 依田 成玄; 越智 陽太郎; 竹田 淳恵; 佐伯 龍之介; Lanying Zhao; Haferlach Torsten; Kanemura Nobuhiro; Kasahara Senji; 牧島 秀樹; 小川 誠司
        日本癌学会総会記事, Sep. 2022
      • 骨髄系腫瘍におけるU2AF2体細胞突然変異によるミススプライシング(Mis-splicing due to somatic U2AF2 mutations in myeloid neoplasms)
        Qi Xingxing; Yoshizatoi Tetuichi; 南谷 泰仁; Nakagawa Masahiro M.; 森 拓人; 昆 彩奈; 依田 成玄; 越智 陽太郎; 竹田 淳恵; 佐伯 龍之介; Lanying Zhao; Haferlach Torsten; Kanemura Nobuhiro; Kasahara Senji; 牧島 秀樹; 小川 誠司
        日本癌学会総会記事, Sep. 2022
      • 骨髄性腫瘍を標的とした新規スプライシングモジュレーターCTX-712の開発(CTX-712, a novel splicing modulator targeting myeloid neoplasms)
        依田 成玄; 森下 大輔; 越智 陽太郎; 水谷 明生; 森 拓人; 竹田 淳恵; 戸崎 浩和; 佐藤 義彦; 南谷 泰仁; 牧島 秀樹; 三宅 洋; 小川 誠司
        日本癌学会総会記事, Sep. 2022
      • 単一細胞マルチオミクス解析によるクローン性造血の病態解明(Distinct pathogenesis of clonal hematopoiesis revealed by single-cell multi-omics sequencing)
        中川 正宏; 稲垣 良作; 南谷 泰仁; 佐伯 龍之介; 越智 陽太郎; 竹田 淳恵; 趙 蘭英; 威 星星; 依田 成玄; 昆 彩奈; 垣内 伸之; 牧島 秀樹; 松田 秀一; 小川 誠司
        日本癌学会総会記事, Sep. 2022
      • 骨髄異形成症候群におけるSRSF2変異とSTAG2変異と協調的関係(Cooperative effects of SRSF2 and STAG2 mutations on development of myelodysplastic syndrome and its related disorders)
        森 拓人; 越智 陽太郎; 昆 彩奈; 吉里 哲一; 古関 明彦; 依田 成玄; 中川 正宏; 竹田 淳恵; 永田 安伸; 吉田 健一; 眞田 昌; 牧島 秀樹; 高折 晃史; 熱田 由子; 南谷 泰仁; 小川 誠司
        日本癌学会総会記事, Sep. 2022
      • CARD11 mutation and HBZ expression induce lymphoproliferative disease and adult T-cell leukemia/lymphoma
        Takuro Kameda; Kotaro Shide; Ayako Kamiunten; Yasunori Kogure; Daisuke Morishita; Junji Koya; Yuki Tahira; Keiichi Akizuki; Takako Yokomizo-Nakano; Sho Kubota; Kosuke Marutsuka; Masaaki Sekine; Tomonori Hidaka; Yoko Kubuki; Yuichi Kitai; Tadashi Matsuda; Akinori Yoda; Takayuki Ohshima; Midori Sugiyama; Goro Sashida; Keisuke Kataoka; Seishi Ogawa; Kazuya Shimoda
        Communications Biology, Dec. 2022
      • The effect of CARD11 mutation and HBZ expression accelerated lymphoproliferative diseases and formed the pathological basis for adult T-cell leukemia/lymphoma
        Kazuya Shimoda; Takuro Kameda; Kotaro Shide; Ayako Kamiunten; Yasunori Kogure; Daisuke Morishita; Junji Koya; Yuki Tahira; Keiichi Akizuki; Takako Yokomizo-Nakano; Sho Kubota; Kosuke Marutsuka; Masaaki Sekine; Tomonori Hidaka; Yoko Kubuki; Akinori Yoda; Takayuki Ohshima; Midori Sugiyama; Goro Sashida; Keisuke Kataoka; Seishi Ogawa
        01 Feb. 2022
      • Mis-splicing due to somatic U2AF2 mutations in myeloid neoplasms(和訳中)
        戚 星星; Yoshizatoi Testuichi; 南谷 泰仁; Nakagawa Masahiro M.; 森 拓人; 昆 彩奈; 依田 成玄; 越智 陽太郎; 竹田 淳恵; 佐伯 龍之介; Lanying Zhao; Haferlach Torsten; Kanemura Nobuhiro; Kasahara Senji; 牧島 秀樹; 小川 誠司
        日本癌学会総会記事, Sep. 2022
      • Mis-splicing due to somatic U2AF2 mutations in myeloid neoplasms(和訳中)
        Qi Xingxing; Yoshizatoi Tetuichi; 南谷 泰仁; Nakagawa Masahiro M.; 森 拓人; 昆 彩奈; 依田 成玄; 越智 陽太郎; 竹田 淳恵; 佐伯 龍之介; Lanying Zhao; Haferlach Torsten; Kanemura Nobuhiro; Kasahara Senji; 牧島 秀樹; 小川 誠司
        日本癌学会総会記事, Sep. 2022
      • 骨髄性腫瘍を標的とした新規スプライシングモジュレーターCTX-712の開発(CTX-712, a novel splicing modulator targeting myeloid neoplasms)
        依田 成玄; 森下 大輔; 越智 陽太郎; 水谷 明生; 森 拓人; 竹田 淳恵; 戸崎 浩和; 佐藤 義彦; 南谷 泰仁; 牧島 秀樹; 三宅 洋; 小川 誠司
        日本癌学会総会記事, Sep. 2022
      • 単一細胞マルチオミクス解析によるクローン性造血の病態解明(Distinct pathogenesis of clonal hematopoiesis revealed by single-cell multi-omics sequencing)
        中川 正宏; 稲垣 良作; 南谷 泰仁; 佐伯 龍之介; 越智 陽太郎; 竹田 淳恵; 趙 蘭英; 威 星星; 依田 成玄; 昆 彩奈; 垣内 伸之; 牧島 秀樹; 松田 秀一; 小川 誠司
        日本癌学会総会記事, Sep. 2022
      • 骨髄異形成症候群におけるSRSF2変異とSTAG2変異と協調的関係(Cooperative effects of SRSF2 and STAG2 mutations on development of myelodysplastic syndrome and its related disorders)
        森 拓人; 越智 陽太郎; 昆 彩奈; 吉里 哲一; 古関 明彦; 依田 成玄; 中川 正宏; 竹田 淳恵; 永田 安伸; 吉田 健一; 眞田 昌; 牧島 秀樹; 高折 晃史; 熱田 由子; 南谷 泰仁; 小川 誠司
        日本癌学会総会記事, Sep. 2022
      • Amplified EPOR/JAK2 genes define a unique subtype of acute erythroid leukemia.
        June Takeda; Kenichi Yoshida; Masahiro M Nakagawa; Yasuhito Nannya; Akinori Yoda; Ryunosuke Saiki; Yotaro Ochi; Lanying Zhao; Rurika Okuda; Xingxing Qi; Takuto Mori; Ayana Kon; Kenichi Chiba; Hiroko Tanaka; Yuichi Shiraishi; Ming-Chung Kuo; Cassandra M Kerr; Yasunobu Nagata; Daisuke Morishita; Nobuhiro Hiramoto; Akira Hangaishi; Hideyuki Nakazawa; Ken Ishiyama; Satoru Miyano; Shigeru Chiba; Yasushi Miyazaki; Toshiyuki Kitano; Kensuke Usuki; Nobuo Sezaki; Hisashi Tsurumi; Shuichi Miyawaki; Jaroslaw P Maciejewski; Takayuki Ishikawa; Kazuma Ohyashiki; Arnold Ganser; Michael Heuser; Felicitas Thol; Lee-Yung Shih; Akifumi Takaori-Kondo; Hideki Makishima; Seishi Ogawa
        Blood cancer discovery, 15 Jul. 2022
        Access this paper :
      • 一細胞解像度のがん生物学 変異と発現のマルチオミクス単一細胞解析によって明らかにされたクローン造血における初期変異細胞の有する非細胞自律性作用
        中川 正宏; 稲垣 良作; 南谷 泰仁; 趙 蘭英; 越智 陽太郎; 竹田 淳恵; 戚 星星; 依田 成玄; 昆 彩奈; 吉里 哲一; 垣内 伸之; 牧島 秀樹; 松田 秀一; 小川 誠司
        日本癌学会総会記事, Sep. 2021
      • 新薬開発に向けた産学連携の問題点と将来展望 SRSF2変異を有する骨髄性腫瘍を標的とした新規CLK阻害剤CTX-712の開発
        依田 成玄; 森下 大輔; 越智 陽太郎; 水谷 明生; 竹田 淳恵; 戸崎 浩和; 佐藤 義彦; 南谷 泰仁; 牧島 秀樹; 三宅 洋; 小川 誠司
        日本癌学会総会記事, Sep. 2021
      • 赤白血病におけるゲノム解析と治療標的の検討
        竹田 淳恵; 吉田 健一; 依田 成玄; 南谷 泰仁; 越智 陽太郎; 中川 正宏; 佐伯 龍之介; 白石 友一; 永田 安伸; 高折 晃史; 千葉 滋; 片岡 圭亮; 宮野 悟; 牧島 秀樹; 小川 誠司
        日本癌学会総会記事, Sep. 2021
      • Distinct pathogenesis of clonal hematopoiesis revealed by single-cell sequencing(和訳中)
        中川 正宏; 稲垣 良作; 黒田 隆; 南谷 泰仁; 趙 蘭英; 越智 陽太郎; 竹田 淳恵; 戚 星星; 依田 成玄; 昆 彩奈; 吉里 哲一; 垣内 伸之; 牧島 秀樹; 松田 秀一; 小川 誠司
        日本血液学会学術集会, Sep. 2021
      • SRSF2変異を有する骨髄性腫瘍を標的とした新規CLK阻害剤CTX-712の開発
        依田 成玄; 森下 大輔; 水谷 明生; 越智 陽太郎; 戸崎 浩和; 佐藤 義彦; 竹田 淳恵; 南谷 泰仁; 牧島 秀樹; 三宅 洋; 小川 誠司
        日本癌学会総会記事, Oct. 2020
      • 急性赤白血病におけるJAK阻害剤の検討
        竹田 淳恵; 吉田 健一; 依田 成玄; 南谷 泰仁; 中川 正宏; 越智 陽太郎; 昆 彩奈; 吉里 哲一; 塩澤 裕介; 白石 友一; 千葉 健一; 田中 洋子; 真田 昌; 宮野 悟; 牧島 秀樹; 小川 誠司
        日本癌学会総会記事, Oct. 2020
      • がんの一細胞生物学 骨髄系腫瘍の早期クローン進展の解析
        中川 正宏; 稲垣 良作; 南谷 泰仁; 趙 蘭英; 越智 陽太郎; 竹田 淳恵; 戚 星星; 依田 成玄; 昆 彩奈; 垣内 伸之; 牧島 秀樹; 松田 秀一; 小川 誠司
        日本癌学会総会記事, Oct. 2020
      • SRSF2変異を有する骨髄性腫瘍を標的とした新規CLK阻害剤CTX-712の開発
        依田 成玄; 森下 大輔; 水谷 明生; 越智 陽太郎; 戸崎 浩和; 佐藤 義彦; 竹田 淳恵; 南谷 泰仁; 牧島 秀樹; 三宅 洋; 小川 誠司
        日本癌学会総会記事, Oct. 2020
      • 急性赤白血病におけるJAK阻害剤の検討
        竹田 淳恵; 吉田 健一; 依田 成玄; 南谷 泰仁; 中川 正宏; 越智 陽太郎; 昆 彩奈; 吉里 哲一; 塩澤 裕介; 白石 友一; 千葉 健一; 田中 洋子; 真田 昌; 宮野 悟; 牧島 秀樹; 小川 誠司
        日本癌学会総会記事, Oct. 2020
      • がんの一細胞生物学 骨髄系腫瘍の早期クローン進展の解析
        中川 正宏; 稲垣 良作; 南谷 泰仁; 趙 蘭英; 越智 陽太郎; 竹田 淳恵; 戚 星星; 依田 成玄; 昆 彩奈; 垣内 伸之; 牧島 秀樹; 松田 秀一; 小川 誠司
        日本癌学会総会記事, Oct. 2020
      • Combined Cohesin-RUNX1 Deficiency Synergistically Perturbs Chromatin Looping and Causes Myelodysplastic Syndromes.
        Yotaro Ochi; Ayana Kon; Toyonori Sakata; Masahiro M Nakagawa; Naotaka Nakazawa; Masanori Kakuta; Keisuke Kataoka; Haruhiko Koseki; Manabu Nakayama; Daisuke Morishita; Tatsuaki Tsuruyama; Ryunosuke Saiki; Akinori Yoda; Rurika Okuda; Tetsuichi Yoshizato; Kenichi Yoshida; Yusuke Shiozawa; Yasuhito Nannya; Shinichi Kotani; Yasunori Kogure; Nobuyuki Kakiuchi; Tomomi Nishimura; Hideki Makishima; Luca Malcovati; Akihiko Yokoyama; Kengo Takeuchi; Eiji Sugihara; Taka-Aki Sato; Masashi Sanada; Akifumi Takaori-Kondo; Mario Cazzola; Mineko Kengaku; Satoru Miyano; Katsuhiko Shirahige; Hiroshi I Suzuki; Seishi Ogawa
        Cancer discovery, Jun. 2020, Peer-reviewed
      • Genomic landscape of young ATLL patients identifies frequent targetable CD28 fusions.
        Noriaki Yoshida; Kay Shigemori; Nicholas Donaldson; Christopher Trevisani; Nicolas A Cordero; Kristen E Stevenson; Xia Bu; Fumiko Arakawa; Mai Takeuchi; Koichi Ohshima; Akinori Yoda; Samuel Y Ng; David M Weinstock
        Blood, 23 Apr. 2020, Peer-reviewed
      • Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis.
        Nobuyuki Kakiuchi; Kenichi Yoshida; Motoi Uchino; Takako Kihara; Kotaro Akaki; Yoshikage Inoue; Kenji Kawada; Satoshi Nagayama; Akira Yokoyama; Shuji Yamamoto; Minoru Matsuura; Takahiro Horimatsu; Tomonori Hirano; Norihiro Goto; Yasuhide Takeuchi; Yotaro Ochi; Yusuke Shiozawa; Yasunori Kogure; Yosaku Watatani; Yoichi Fujii; Soo Ki Kim; Ayana Kon; Keisuke Kataoka; Tetsuichi Yoshizato; Masahiro M Nakagawa; Akinori Yoda; Yasuhito Nanya; Hideki Makishima; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Masashi Sanada; Eiji Sugihara; Taka-Aki Sato; Takashi Maruyama; Hiroyuki Miyoshi; Makoto Mark Taketo; Jun Oishi; Ryosaku Inagaki; Yutaka Ueda; Shinya Okamoto; Hideaki Okajima; Yoshiharu Sakai; Takaki Sakurai; Hironori Haga; Seiichi Hirota; Hiroki Ikeuchi; Hiroshi Nakase; Hiroyuki Marusawa; Tsutomu Chiba; Osamu Takeuchi; Satoru Miyano; Hiroshi Seno; Seishi Ogawa
        Nature, Jan. 2020
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      • Molecular pathogenesis of disease progression in MLL-rearranged AML.
        Shinichi Kotani; Akinori Yoda; Ayana Kon; Keisuke Kataoka; Yotaro Ochi; Yusuke Shiozawa; Cassandra Hirsch; June Takeda; Hiroo Ueno; Tetsuichi Yoshizato; Kenichi Yoshida; Masahiro M Nakagawa; Yasuhito Nannya; Nobuyuki Kakiuchi; Takuji Yamauchi; Kosuke Aoki; Yuichi Shiraishi; Satoru Miyano; Takahiro Maeda; Jaroslaw P Maciejewski; Akifumi Takaori-Kondo; Seishi Ogawa; Hideki Makishima
        Leukemia, Mar. 2019, Peer-reviewed
      • Genome-Wide Analysis of Non-Coding Alterations in Pan-Myeloid Cancers Using Whole Genome Sequencing
        Nannya, Yasuhito; Yoshida, Kenichi; Zhao, Lanying; Takeda, June; Ueno, Hiroo; Yoshizato, Tetsuichi; Yoda, Akinori; Nakagawa, Masahiro; Makishima, Hideki; Tanaka, Hiroko; Hiramoto, Nobuhiro; Muto, Hideharu; Fuji, Shigeo; Polprasert, Chantana; Damm, Frederik; Usuki, Kensuke; Taguchi, Masataka; Chiba, Shigeru; Miyawaki, Shuichi; Shih, Lee-Yung; Tsurumi, Hisashi; Kasahara, Senji; Malcovati, Luca; Ishikawa, Takayuki; Jansen, Joop H; Miyazaki, Yasushi; Miyano, Satoru; Cazzola, Mario; Ogawa, Seishi
        BLOOD, Nov. 2018
      • Differential Regulation of the Melanoma Proteome by eIF4A1 and eIF4E.
        Cailin E Joyce; Adrienne G Yanez; Akihiro Mori; Akinori Yoda; Johanna S Carroll; Carl D Novina
        Cancer research, 01 Feb. 2017, Peer-reviewed
      • Tumor-suppressor genes that escape from X-inactivation contribute to cancer sex bias.
        Andrew Dunford; David M Weinstock; Virginia Savova; Steven E Schumacher; John P Cleary; Akinori Yoda; Timothy J Sullivan; Julian M Hess; Alexander A Gimelbrant; Rameen Beroukhim; Michael S Lawrence; Gad Getz; Andrew A Lane
        Nature genetics, Jan. 2017, Peer-reviewed
      • The Mediator Kinase Module Restrains Epidermal Growth Factor Receptor Signaling and Represses Vulval Cell Fate Specification in Caenorhabditis elegans.
        Jennifer M Grants; Lisa T L Ying; Akinori Yoda; Charlotte C You; Hideyuki Okano; Hitoshi Sawa; Stefan Taubert
        Genetics, Feb. 2016, Peer-reviewed
      • Activity of the Type II JAK2 Inhibitor CHZ868 in B Cell Acute Lymphoblastic Leukemia.
        Shuo-Chieh Wu; Loretta S Li; Nadja Kopp; Joan Montero; Bjoern Chapuy; Akinori Yoda; Amanda L Christie; Huiyun Liu; Alexandra Christodoulou; Diederik van Bodegom; Jordy van der Zwet; Jacob V Layer; Trevor Tivey; Andrew A Lane; Jeremy A Ryan; Samuel Y Ng; Daniel J DeAngelo; Richard M Stone; David Steensma; Martha Wadleigh; Marian Harris; Emeline Mandon; Nicolas Ebel; Rita Andraos; Vincent Romanet; Arno Dölemeyer; Dario Sterker; Michael Zender; Scott J Rodig; Masato Murakami; Francesco Hofmann; Frank Kuo; Michael J Eck; Lewis B Silverman; Stephen E Sallan; Anthony Letai; Fabienne Baffert; Eric Vangrevelinghe; Thomas Radimerski; Christoph Gaul; David M Weinstock
        Cancer cell, 13 Jul. 2015, Peer-reviewed
      • Targeting oncogenic interleukin-7 receptor signalling with N-acetylcysteine in T cell acute lymphoblastic leukaemia.
        Marc R Mansour; Casie Reed; Amy R Eisenberg; Jen-Chieh Tseng; Jean-Claude Twizere; Sarah Daakour; Akinori Yoda; Scott J Rodig; Noa Tal; Chen Shochat; Alla Berezovskaya; Daniel J DeAngelo; Stephen E Sallan; David M Weinstock; Shai Izraeli; Andrew L Kung; Alex Kentsis; A Thomas Look
        British journal of haematology, Jan. 2015, Peer-reviewed
      • Mutations in G protein β subunits promote transformation and kinase inhibitor resistance.
        Akinori Yoda; Guillaume Adelmant; Jerome Tamburini; Bjoern Chapuy; Nobuaki Shindoh; Yuka Yoda; Oliver Weigert; Nadja Kopp; Shuo-Chieh Wu; Sunhee S Kim; Huiyun Liu; Trevor Tivey; Amanda L Christie; Kutlu G Elpek; Joseph Card; Kira Gritsman; Jason Gotlib; Michael W Deininger; Hideki Makishima; Shannon J Turley; Nathalie Javidi-Sharifi; Jaroslaw P Maciejewski; Siddhartha Jaiswal; Benjamin L Ebert; Scott J Rodig; Jeffrey W Tyner; Jarrod A Marto; David M Weinstock; Andrew A Lane
        Nature medicine, Jan. 2015, Peer-reviewed
      • Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation.
        Andrew A Lane; Bjoern Chapuy; Charles Y Lin; Trevor Tivey; Hubo Li; Elizabeth C Townsend; Diederik van Bodegom; Tovah A Day; Shuo-Chieh Wu; Huiyun Liu; Akinori Yoda; Gabriela Alexe; Anna C Schinzel; Timothy J Sullivan; Sébastien Malinge; Jordan E Taylor; Kimberly Stegmaier; Jacob D Jaffe; Michael Bustin; Geertruy te Kronnie; Shai Izraeli; Marian H Harris; Kristen E Stevenson; Donna Neuberg; Lewis B Silverman; Stephen E Sallan; James E Bradner; William C Hahn; John D Crispino; David Pellman; David M Weinstock
        Nature genetics, Jun. 2014, Peer-reviewed
      • TSLP signaling pathway map: a platform for analysis of TSLP-mediated signaling.
        Jun Zhong; Jyoti Sharma; Rajesh Raju; Shyam Mohan Palapetta; T S Keshava Prasad; Tai-Chung Huang; Akinori Yoda; Jeffrey W Tyner; Diederik van Bodegom; David M Weinstock; Steven F Ziegler; Akhilesh Pandey
        Database : the journal of biological databases and curation, 2014, Peer-reviewed
      • Differences in signaling through the B-cell leukemia oncoprotein CRLF2 in response to TSLP and through mutant JAK2.
        Diederik van Bodegom; Jun Zhong; Nadja Kopp; Chaitali Dutta; Min-Sik Kim; Liat Bird; Oliver Weigert; Jeffrey Tyner; Akhilesh Pandey; Akinori Yoda; David M Weinstock
        Blood, 04 Oct. 2012, Peer-reviewed
      • BCL2 suppresses PARP1 function and nonapoptotic cell death.
        Chaitali Dutta; Tovah Day; Nadja Kopp; Diederik van Bodegom; Matthew S Davids; Jeremy Ryan; Liat Bird; Naveen Kommajosyula; Oliver Weigert; Akinori Yoda; Hua Fung; Jennifer R Brown; Geoffrey I Shapiro; Anthony Letai; David M Weinstock
        Cancer research, 15 Aug. 2012, Peer-reviewed
      • TSLP signaling network revealed by SILAC-based phosphoproteomics.
        Jun Zhong; Min-Sik Kim; Raghothama Chaerkady; Xinyan Wu; Tai-Chung Huang; Derese Getnet; Christopher J Mitchell; Shyam M Palapetta; Jyoti Sharma; Robert N O'Meally; Robert N Cole; Akinori Yoda; Albrecht Moritz; Marc M Loriaux; John Rush; David M Weinstock; Jeffrey W Tyner; Akhilesh Pandey
        Molecular & cellular proteomics : MCP, Jun. 2012, Peer-reviewed
      • Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibition.
        Oliver Weigert; Andrew A Lane; Liat Bird; Nadja Kopp; Bjoern Chapuy; Diederik van Bodegom; Angela V Toms; Sachie Marubayashi; Amanda L Christie; Michael McKeown; Ronald M Paranal; James E Bradner; Akinori Yoda; Christoph Gaul; Eric Vangrevelinghe; Vincent Romanet; Masato Murakami; Ralph Tiedt; Nicolas Ebel; Emeline Evrot; Alain De Pover; Catherine H Régnier; Dirk Erdmann; Francesco Hofmann; Michael J Eck; Stephen E Sallan; Ross L Levine; Andrew L Kung; Fabienne Baffert; Thomas Radimerski; David M Weinstock
        The Journal of experimental medicine, 13 Feb. 2012, Peer-reviewed
      • Molecular ontogeny of donor-derived follicular lymphomas occurring after hematopoietic cell transplantation.
        Oliver Weigert; Nadja Kopp; Andrew A Lane; Akinori Yoda; Suzanne E Dahlberg; Donna Neuberg; Anita Y Bahar; Bjoern Chapuy; Jeffery L Kutok; Janina A Longtine; Frank C Kuo; Terry Haley; Maura Salois; Timothy J Sullivan; David C Fisher; Edward A Fox; Scott J Rodig; Joseph H Antin; David M Weinstock
        Cancer discovery, Jan. 2012, Peer-reviewed
      • Next-generation cDNA screening for oncogene and resistance phenotypes.
        Nobuaki Shindoh; Akinori Yoda; Yuka Yoda; Timothy J Sullivan; Oliver Weigert; Andrew A Lane; Nadja Kopp; Liat Bird; Scott J Rodig; Edward A Fox; David M Weinstock
        PloS one, 2012, Peer-reviewed
      • t(X;14)(p22;q32)/t(Y;14)(p11;q32) CRLF2-IGH translocations from human B-lineage ALLs involve CpG-type breaks at CRLF2, but CRLF2/P2RY8 intrachromosomal deletions do not.
        Albert G Tsai; Akinori Yoda; David M Weinstock; Michael R Lieber
        Blood, 16 Sep. 2010, Peer-reviewed
      • Down syndrome acute lymphoblastic leukemia, a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: a report from the International BFM Study Group.
        Libi Hertzberg; Elena Vendramini; Ithamar Ganmore; Gianni Cazzaniga; Maike Schmitz; Jane Chalker; Ruth Shiloh; Ilaria Iacobucci; Chen Shochat; Sharon Zeligson; Gunnar Cario; Martin Stanulla; Sabine Strehl; Lisa J Russell; Christine J Harrison; Beat Bornhauser; Akinori Yoda; Gideon Rechavi; Dani Bercovich; Arndt Borkhardt; Helena Kempski; Geertruy te Kronnie; Jean-Pierre Bourquin; Eytan Domany; Shai Izraeli
        Blood, 04 Feb. 2010, Peer-reviewed
      • Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia.
        Akinori Yoda; Yuka Yoda; Sabina Chiaretti; Michal Bar-Natan; Kartik Mani; Scott J Rodig; Nathan West; Yun Xiao; Jennifer R Brown; Constantine Mitsiades; Martin Sattler; Jeffrey L Kutok; Daniel J DeAngelo; Martha Wadleigh; Alfonso Piciocchi; Paola Dal Cin; James E Bradner; James D Griffin; Kenneth C Anderson; Richard M Stone; Jerome Ritz; Robin Foà; Jon C Aster; David A Frank; David M Weinstock
        Proceedings of the National Academy of Sciences of the United States of America, 05 Jan. 2010, Peer-reviewed
      • Arsenic trioxide augments Chk2/p53-mediated apoptosis by inhibiting oncogenic Wip1 phosphatase.
        Akinori Yoda; Kyoko Toyoshima; Yasuhide Watanabe; Nobuyuki Onishi; Yuki Hazaka; Yusuke Tsukuda; Junichi Tsukada; Takeshi Kondo; Yoshiya Tanaka; Yasuhiro Minami
        The Journal of biological chemistry, 04 Jul. 2008, Peer-reviewed
      • [Relationship between abnormalities of genes involved in DNA damage responses and malignant tumors/autoimmune diseases].
        Sa Kan Yoo; Nobuyuki Onishi; Naoko Kato; Akinori Yoda; Yasuhiro Minami
        Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology, Jun. 2006, Peer-reviewed
      • Oda5p, a novel axonemal protein required for assembly of the outer dynein arm and an associated adenylate kinase.
        Maureen Wirschell; Gregory Pazour; Akinori Yoda; Masafumi Hirono; Ritsu Kamiya; George B Witman
        Molecular biology of the cell, Jun. 2004, Peer-reviewed
      • Loss of mRor1 enhances the heart and skeletal abnormalities in mRor2-deficient mice: Redundant and pleiotropic functions of mRor1 and mRor2 receptor tyrosine kinases
        M Nomi; Oishi, I; S Kani; H Suzuki; T Matsuda; A Yoda; M Kitamura; K Itoh; S Takeuchi; K Takeda; S Akira; M Ikeya; S Takada; Y Minami
        MOLECULAR AND CELLULAR BIOLOGY, Dec. 2001, Peer-reviewed
      • MSI-1, a neural RNA-binding protein, is involved in male mating behaviour in Caenorhabditis elegans.
        Yoda A; Sawa H; Okano H
        Genes to cells : devoted to molecular & cellular mechanisms, Nov. 2000, Peer-reviewed
      • The human Musashi homolog 1 (MSI1) gene encoding the homologue of Musashi/Nrp-1, a neural RNA-binding protein putatively expressed in CNS stem cells and neural progenitor cells
        Good Peter; Yoda Akinori; Sakakibara Shin Ichi; Yamamoto Atsuyo; Imai Takao; Sawa Hitoshi; Ikeuchi Takeshi; Tsuji Shoji; Satoh Hitoshi; Okano Hideyuki
        Genomics, 15 Sep. 1998

      Misc.

      • DNA損傷応答におけるChk2キナーゼの機能及びChk2の異常と悪性腫瘍との関連
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        放射線生物研究, Sep. 2002
      • Amplified EPOR/JAK2 genes definea unique subtype of acute erythroid leukemia.
        June Takeda; Kenichi Yoshida; Masahiro M. Nakagawa; Yasuhito Nannya; Akinori Yoda; Ryunosuke Saiki; Yotaro Ochi; Lanying Zhao; Rurika Okuda; Xingxing Qi; Takuto Mori; Ayana Kon; Kenichi Chiba; Hiroko Tanaka; Yuichi Shiraishi; Ming-Chung Kuo; Cassandra Kerr; Yasunobu Nagata; Daisuke Morishita; Nobuhiro Hiramoto; Akira Hangaishi; Hideyuki Nakazawa; Ken Ishiyama; Satoru Miyano; Shigeru Chiba; Yasushi Miyazaki; Toshiyuki Kitano; Kensuke Usuki; Nobuo Sezaki; Hisashi Tsurumi; Shuichi Miyawaki; Jaroslaw P. Maciejewski; Takayuki Ishikawa; Kazuma Ohyashiki; Arnold Ganser; Michael Heuser; Felicitas Thol; Lee-Yung Shih; Akifumi Takaori-Kondo; Hideki Makishima; Seishi Ogawa
        CANCER RESEARCH, Jun. 2022
      • EPOR/JAK/STAT Signaling Pathway As Therapeutic Target of Acute Erythroid Leukemia
        June Takeda; Kenichi Yoshida; Masahiro Marshall Nakagawa; Yasuhito Nannya; Akinori Yoda; Daisuke Morishita; Ryunosuke Saiki; Kenichi Chiba; Hiroko Tanaka; Yuichi Shiraishi; Ming-Chung Kuo; Cassandra M. Kerr; Yasunobu Nagata; Nobuhiro Hiramoto; Akira Hangaishi; Hideyuki Nakazawa; Ken Ishiyama; Satoru Miyano; Shigeru Chiba; Yasushi Miyazaki; Toshiyuki Kitano; Kensuke Usuki; Nobuo Sezaki; Hisashi Tsurumi; Shuichi Miyawaki; Jaroslaw P. Maciejewski; Takayuki Ishikawa; Kazuma Ohyashiki; Arnold Ganser; Michael Heuser; Felicitas Thol; Lee-Yung Shih; Akifumi Takaori-Kondo; Hideki Makishima; Seishi Ogawa
        BLOOD, Nov. 2021
      • 変異と発現のマルチオミクス単一細胞解析によって明らかにされたクローン造血における初期変異細胞の有する非細胞自律性作用
        中川正宏; 稲垣良作; 南谷泰仁; 趙蘭英; 趙蘭英; 越智陽太郎; 竹田淳恵; 戚星星; 依田成玄; 昆彩奈; 吉里哲一; 垣内伸之; 牧島秀樹; 松田秀一; 小川誠司; 小川誠司; 小川誠司
        日本癌学会学術総会抄録集(Web), 2021
      • 細胞周期チェックポイントのオン・オフ機構
        大西 伸幸; 西田 満; 依田 成玄
        放射線生物研究, Jun. 2005
      • WntとRor2によるPCP経路の制御 (特集 Wntシグナルとその多彩な機能--細胞極性・細胞運動・幹細胞の自己複製・発癌)
        依田 成玄; 可児 修一; 南 康博
        細胞工学, Jun. 2004
      • Analysis of C. elegans RNA-binding protein, MSI-1 and search for new related genes
        YODA Akinori; SAWA Hitoshi; OKANO Hideyuki
        日本分子生物学会年会プログラム・講演要旨集, 01 Dec. 1998
      • 赤白血病におけるゲノム解析と治療標的の検討
        竹田淳恵; 吉田健一; 依田成玄; 南谷泰仁; 越智陽太郎; 中川正宏; 佐伯龍之介; 白石友一; 永田安伸; 高折晃史; 千葉滋; 片岡圭亮; 宮野悟; 牧島秀樹; 小川誠司; 小川誠司; 小川誠司
        日本癌学会学術総会抄録集(Web), 2021
      • MALT1阻害薬はMALT1活性を有するATLの増殖を抑制する
        上運天綾子; 森下大輔; 亀田拓郎; 木暮泰寛; 依田成玄; 越智陽太郎; 水谷明生; 杉山緑; 長谷川寛雄; 今泉芳孝; 安永純一朗; 松岡雅雄; 石塚賢治; 片岡圭亮; 片岡圭亮; 小川誠司; 下田和哉
        日本HTLV-1学会学術集会, 2021
      • Early Clonal evolution of myeloid malignancies
        Masahiro Nakagawa; Ryosaku Inagaki; Yasuhito Nannya; Lanying Zhao; Yotaro Ochi; June Takeda; Xingxing Qi; Akinori Yoda; Ayana Kon; Nobuyuki Kakiuchi; Hideki Makishima; Shinichi Matsuda; Seishi Ogawa
        CANCER SCIENCE, Feb. 2021
      • JAK STAT Pathway is a Promising Therapeutic target in Acute Erythroid Leukemia
        June Takeda; Kenichi Yoshida; Akinori Yoda; Yasuhito Nannya; Masahiro Nakagawa; Yotaro Ochi; Ayana Kon; Tetsuichi Yoshizato; Yusuke Shiozawa; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Masashi Sanada; Satoru Miyano; Hideki Makishima; Seishi Ogawa
        CANCER SCIENCE, Feb. 2021
      • CTX-712, a novel CLK inhibitor targeting myeloid neoplasms with SRSF2 mutation
        Akinori Yoda; Daisuke Morishita; Akio Mizutani; Yotaro Ochi; Hirokazu Tozaki; Yoshihiko Satoh; June Takeda; Yasuhito Nannya; Hideki Makishima; Hiroshi Miyake; Seishi Ogawa
        CANCER SCIENCE, Feb. 2021
      • Preclinical Evaluation of a Novel MALT1 Inhibitor CTX-177 for Relapse/Refractory Lymphomas
        Daisuke Morishita; Akio Mizutani; Hirokazu Tozaki; Yasuyoshi Arikawa; Takuro Kameda; Ayako Kamiunten; Keisuke Kataoka; Akinori Yoda; Yotaro Ochi; Kotaro Shide; Koji Izutsu; Yosuke Minami; Kazuya Shimoda; Hiroshi Miyake; Seishi Ogawa
        BLOOD, Nov. 2020
      • Distinct Pathogenesis of Clonal Hematopoiesis Revealed By Single Cell RNA Sequencing Integrated with Highly Sensitive Genotyping Method
        Masahiro Marshall Nakagawa; Ryosaku Inagaki; Yutaka Kuroda; Yasuhito Nannya; Lanying Zhao; Yotaro Ochi; June Takeda; Qi Xingxing; Akinori Yoda; Ayana Kon; Nobuyuki Kakiuchi; Hideki Makishima; Shuichi Matsuda; Seishi Ogawa
        BLOOD, Nov. 2020
      • Genotype-Phenotype Relationships and Therapeutic Targets in Acute Erythroid Leukemia
        June Takeda; Kenichi Yoshida; Akinori Yoda; Lee-Yung Shih; Yasuhito Nannya; Yotaro Ochi; Ayana Kon; Kenichi Chiba; Yuichi Shiraishi; Yusuke Shiozawa; Tetsuichi Yoshizato; Cassandra M. Kerr; Yasunobu Nagata; Toshiyuki Kitano; Akira Hangaishi; Ken Ishiyama; Hisashi Tsurumi; Yasushi Miyazaki; Nobuhiro Hiramoto; Takayuki Ishikawa; Masahiro Marshall Nakagawa; Akifumi Takaori-Kondo; Shigeru Chiba; Hideyuki Nakazawa; Ming-Chung Kuo; Keisuke Kataoka; Ryunosuke Saiki; Hiroko Tanaka; Kensuke Usuki; Shuichi Miyawaki; Satoru Miyano; Jaroslaw P. Maciejewski; Arnold Ganser; Michael Heuser; Felicitas Thol; Hideki Makishima; Seishi Ogawa
        BLOOD, Nov. 2020
      • 急性赤白血病に対するJAK-STATパスウェイ阻害薬の有用性の検討
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        日本血液学会学術集会抄録(Web), 2020
      • 単一細胞でのRNA/DNA同時シーケンスによるクローン造血の病態解明
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        日本血液学会学術集会抄録(Web), 2020
      • CTX-712, a Novel Clk Inhibitor Targeting Myeloid Neoplasms with SRSF2 Mutation
        Akinori Yoda; Daisuke Morishita; Akio Mizutani; Yoshihiko Satoh; Yotaro Ochi; Yasuhito Nannya; Hideki Makishima; Hiroshi Miyake; Seishi Ogawa
        BLOOD, Nov. 2019
      • Novel Molecular Pathogenesis and Therapeutic Target in Acute Erythroid Leukemia
        June Takeda; Kenichi Yoshida; Yasuhito Nannya; Lee-Yung Shih; Ayana Kon; Akinori Yoda; Yotaro Ochi; Yusuke Shiozawa; Tetsuichi Yoshizato; Cassandra M. Kerr; Yuichi Shiraishi; Kenichi Chiba; Yasunobu Nagata; Akira Hangaishi; Toshiyuki Kitano; Ken Ishiyama; Hisashi Tsurumi; Yasushi Miyazaki; Nobuhiro Hiramoto; Takayuki Ishikawa; Akifumi Takaori-Kondo; Masahiro Nakagawa; Masashi Sanada; Hideyuki Nakazawa; Keisuke Kataoka; Ryunosuke Saiki; Hiroko Tanaka; Kensuke Usuki; Shuichi Miyawaki; Satoru Miyano; Arnold Ganser; Michael Heuser; Jaroslaw P. Maciejewski; Felicitas Thol; Hideki Makishima; Seishi Ogawa
        BLOOD, Nov. 2019
      • 成人T細胞白血病リンパ腫に対する新規テーラーメイド治療の確立
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        日本HTLV-1学会学術集会, 2019
      • 潰瘍性大腸炎における上皮細胞の陽性選択
        垣内伸之; 垣内伸之; 内野基; 木原多佳子; 赤木宏太朗; 井上善景; 長山聡; 横山顕礼; 平野智紀; 平野智紀; 竹内康英; 竹内康英; 越智陽太郎; 塩澤裕介; 片岡圭亮; 中川正宏; 依田成玄; 南谷泰仁; 牧島秀樹; 白石友一; 千葉健一; 真田昌; 三好弘之; 坂井義治; 桜井孝規; 羽賀博典; 廣田誠一; 池内浩基; 竹内理; 宮野悟; 妹尾浩; 小川誠司
        日本分子生物学会年会プログラム・要旨集(Web), 2019
      • Combined Stag2/Runx1 loss causes myelodysplatic syndrome through perturbed enhancer interactions
        越智陽太郎; 越智陽太郎; 昆彩奈; 中川正宏; 片岡圭亮; 古関明彦; 佐伯龍之介; 吉里哲一; 吉田健一; 依田成玄; 鈴木洋; 鶴山竜昭; 牧島秀樹; 塩澤裕介; 南谷泰仁; 杉原英志; 佐藤孝明; 真田昌; 高折晃史; 宮野悟; 小川誠司
        日本癌学会学術総会抄録集(Web), 2019
      • Type II JAK2 inhibitor NVP-CHZ868 has potent activity in JAK2-dependent B-cell acute lymphoblastic leukemias (B-ALLs) in vivo.
        Loretta S. Li; Nadja Kopp; Shuo-Chieh Wu; Jordy Van Der Zwet; Jacob V. Layer; Oliver Weigert; Amanda L. Christie; Alexandra N. Christodoulou; Huiyun Liu; Akinori Yoda; Thomas Radimerski; David M. Weinstock
        CLINICAL CANCER RESEARCH, Sep. 2015
      • Type II JAK2 Inhibitor NVP-CHZ868 Is Active in Vivo Against JAK2-Dependent B-Cell Acute Lymphoblastic Leukemias (B-ALLs)
        Loretta S. Li; Shuo-Chieh Wu; Nadja Kopp; Joan Montero; Jeremy Ryan; Bjoern Chapuy; Jordy C. Van der Zwet; Jacob Layer; Oliver Weigert; Amanda L. Christie; Alexandra N. Christodoulou; Huiyun Liu; Akinori Yoda; Francesco Hofmann; Fabienne Baffert; Eric Vangrevelinghe; Christoph Gaul; Thomas Radimerski; Anthony G. Letai; David M. Weinstock
        BLOOD, Dec. 2014
      • GNB1 Activating Mutations Promote Myeloid and Lymphoid Neoplasms Targetable By Combined PI3K/mTOR Inhibition
        Akinori Yoda; Guillaume Adelmant; Jerome Tamburini; Bjoern Chapuy; Nobuaki Shindoh; Yuka Yoda; Oliver Weigert; Nadja Kopp; Shuo-Chieh Wu; Sunhee S. Kim; Huiyun Liu; Trevor Tivey; Amanda L. Christie; Kutlu G. Elpek; Joseph Card; Kira Gritsman; Jason Gotlib; Michael W. Deininger; Hideki Makishima; Shannon Turley; Nathalie Javidi-Sharifi; Jaroslaw P. Maciejewski; Scott J. Rodig; Jeffrey W. Tyner; Jarrod A. Marto; David M. Weinstock; Andrew A. Lane
        BLOOD, Dec. 2014
      • Triplication of HMGN1 promotes B cell acute lymphoblastic leukemia (B-ALL) through suppression of H3K27me3
        Andrew A. Lane; Bjoern Chapuy; Charles Y. Lin; Trevor Tivey; Hubo Li; Elizabeth Townsend; Diederik van Bodegom; Tovah A. Day; Shuo-Chieh Wu; Huiyun Liu; Akinori Yoda; Gabriela Alexe; Anna Schinzel; Timothy J. Sullivan; Sebastien Malinge; Jordan Taylor; Kimberly Stegmaier; Jacob Jaffe; Michael Bustin; Geertruy te Kronnie; Shai Izraeli; Marian Harris; Kristen Stevenson; Donna Neuberg; Lewis B. Silverman; Steven E. Sallan; James E. Bradner; William C. Hahn; John D. Crispino; David Pellman; David M. Weinstock
        CANCER RESEARCH, Oct. 2014
      • Loss-Of-Function Mutations In The Splicing Factor ZRSR2 Are Common In Blastic Plasmacytoid Dendritic Cell Neoplasm and Have Male Predominance
        Justin Taylor; Sunhee S. Kim; Kristen E. Stevenson; Akinori Yoda; Nadja Kopp; Abner Louissaint; Nancy Lee Harris; Ephraim P. Hochberg; Yi-Bin Chen; Scott B. Lovitch; Daniel J. DeAngelo; Martha Wadleigh; David P. Steensma; Gabriela Motyckova; Richard M. Stone; Donna S. Neuberg; Fabrice Jardin; Pier Paolo Piccaluga; David M. Weinstock; Andrew A. Lane
        BLOOD, Nov. 2013
      • The Beta-Subunit Of Heterotrimeric G Proteins Harbors Gain-Of-Function Mutations In Multiple Hematologic Malignancies
        Akinori Yoda; Guillaume Adelmant; Nobuaki Shindoh; Bjoern Chapuy; Yuka Yoda; Oliver Weigert; Nadja Kopp; Shuo-Chieh Wu; Sunhee S. Kim; Huiyun Liu; Trevor Tivey; Jeffrey W. Tyner; Jason Gotlib; Michael W. Deininger; Shannon Turley; Jarrod A. Marto; Andrew A. Lane; David M. Weinstock
        BLOOD, Nov. 2013
      • Molecular Ontogeny of Donor-Derived Lymphomas Occurring After Transplantation
        Oliver Weigert; Nadja Kopp; Andrew A. Lane; Akinori Yoda; Suzanne E. Dahlberg; Donna Neuberg; Anita Y. Bahar; Bjoern Chapuy; Frank Kuo; Terry Haley; Timothy J. Sullivan; Edward Fox; Scott J. Rodig; Joseph H. Antin; David M. Weinstock
        BLOOD, Nov. 2011
      • HSP90 Inhibition Targets JAK2 and Is Highly Effective in CRLF2-Rearranged Acute Lymphoblastic Leukemia
        Oliver Weigert; Liat Bird; Nadja Kopp; Andrew A. Lane; Bjoern Chapuy; Diederik van Bodegom; Sachie Marubayashi; Akinori Yoda; Vincent Romanet; Masato Murakami; Stephen E. Sallan; Ross L. Levine; Andrew L. Kung; Thomas Radimerski; David M. Weinstock
        BLOOD, Nov. 2011
      • Functional oncogene identification in hematologic malignancies
        Oliver Weigert; Andrew Lane; Nadja Kopp; Scott Rodig; Akinori Yoda; David M. Weinstock
        CANCER RESEARCH, Apr. 2011
      • Next Generation Sequencing Identifies Novel Oncogene Alterations In CRLF2-rearranged Precursor B-Cell Acute Lymphoblastic Leukemia
        Akinori Yoda; Terry Haley; Oliver B. Weigert; Jeffery Kutok; Adalis Maisonet; Maura Salois; Edward Fox; David M. Weinstock
        BLOOD, Nov. 2010
      • CRLF2/JAK Signaling in Adult and Pediatric Acute Lymphoblastic Leukemia Is Highly Similar to BCR/ABL.
        Kartik Mani; Akinori Yoda; Sabina Chiaretti; Robin Foa; David M. Weinstock
        BLOOD, Nov. 2009
      • Mechanisms of CRLF2 Rearrangement with IGH and P2RY8 in B-Cell Acute Lymphoblastic Leukemia
        David M. Miller; Akinori Yoda; Yuka Yoda; David M. Weinstock
        BLOOD, Nov. 2009
      • DOWN'S Syndrome Acute Lymphoblastic LEUKEMIA: A HIGHLY Heterogeneous DISEASE DRIVEN by an Aberrant CRLF2/JAK2 Cooperation - A REPORT FROM the Ibfm-STUDY GROUP
        Libi Hertzberg; Elena Vendramini; Ithamar Ganmore; Giovanni Cazzaniga; Maike Schmitz; Ruth Shiloh; Jane Chalker; Ilaria Iacobucci; Chen Shochat; Sharon Zeligson; Gunnar Cario; Martin Stanulla; Sabine Strehl; Lisa J. Russel; Christine Harrison; Beat Bornhauser; Akinori Yoda; Gideon Rechavi; Dani Bercovich; Arndt Borkardt; Helena Kempski; Geertruy te Kronnie; Jean-Pierre Bourquin; Eytan Domany; Shai Izraeli
        BLOOD, Nov. 2009
      • CRLF2/JAK Signaling Confers Susceptibility to JAK Inhibitors and Small Molecule Inhibitors of Protein Kinase C.
        C. Nathan West; Akinori Yoda; Sabina Chiaretti; Kartik Mani; Robin Foa; James Bradner; David M. Weinstock
        BLOOD, Nov. 2009
      • CRLF2 is a proto-oncogene in pre-B acute lymphoblastic leukemia with normal cytogenetics
        Akinori Yoda; Michal Bar-Natan; Martin Sattler; Jerome Ritz; David Frank; David Weinstock
        CANCER RESEARCH, May 2009
      • Chk2 kinase is required for methylglyoxal-induced G(2)/M cell-cycle checkpoint arrest: implication of cell-cycle checkpoint regulation in diabetic oxidative stress signaling
        Shuichi Kani; Emiko Nakayama; Akinori Yoda; Nobuyuki Onishi; Nagako Sougawa; Yuki Hazaka; Tsuyoshi Umeda; Kohsuke Takeda; Hidenori Ichijo; Yasuhiro Hamada; Yasuhiro Minami
        GENES TO CELLS, Aug. 2007
      • Chk2 kinase is required for methylglyoxal-induced G2/M cell-cycle checkpoint arrest: implication of cell-cycle checkpoint regulation in diabetic oxidative stress signaling.
        Shuichi Kani; Emiko Nakayama; Akinori Yoda; Nobuyuki Onishi; Nagako Sougawa; Yuki Hazaka; Tsuyoshi Umeda; Kohsuke Takeda; Hidenori Ichijo; Yasuhiro Hamada; Yasuhiro Minami
        Genes to cells : devoted to molecular & cellular mechanisms, Aug. 2007
      • Intrinsic kinase activity and SQ/TQ domain of Chk2 kinase as well as N-terminal domain of Wip1 phosphatase are required for regulation of Chk2 by Wip1.
        Akinori Yoda; Xiao Zhou Xu; Nobuyuki Onishi; Kyoko Toyoshima; Hiroko Fujimoto; Naoko Kato; Isao Oishi; Takeshi Kondo; Yasuhiro Minami
        The Journal of biological chemistry, 25 Aug. 2006
      • Intrinsic kinase activity and SQ/TQ domain of Chk2 kinase as well as N-terminal domain of Wip1 phosphatase are required for regulation of Chk2 by Wip1
        Akinori Yoda; Xiao Zhou Xu; Nobuyuki Onishi; Kyoko Toyoshima; Hiroko Fujimoto; Naoko Kato; Isao Oishi; Takeshi Kondo; Yasuhiro Minami
        JOURNAL OF BIOLOGICAL CHEMISTRY, Aug. 2006
      • Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase
        H. Fujimoto; N. Onishi; N. Kato; M. Takekawa; X. Z. Xu; A. Kosugi; T. Kondo; M. Imamura; I. Oishi; A. Yoda; Y. Minami
        CELL DEATH AND DIFFERENTIATION, Jul. 2006
      • Relationship between abnormalities of genes involved in DNA damage responses and malignant tumors/autoimmune diseases
        Sa Kan Yoo; Nobuyuki Onishi; Naoko Kato; Akinori Yoda; Yasuhiro Minami
        Japanese Journal of Clinical Immunology, 2006
      • Ror2-mediated cytoskeletal reorganization by differential regulation of Dishevelled proteins
        Akira Nomachi; Michiru Nishita; Shuichi Kani; Akira Kikuchi; Akinori Yoda; Yasuhiro Minami
        CELL STRUCTURE AND FUNCTION, Jun. 2005
      • Components of the transcriptional Mediator complex are required for asymmetric cell division in C. elegans.
        Akinori Yoda; Hiroko Kouike; Hideyuki Okano; Hitoshi Sawa
        Development (Cambridge, England), Apr. 2005
      • Components of the transcriptional Mediator complex are required for asymmetric cell division in C-elegans
        A Yoda; H Kouike; H Okano; H Sawa
        DEVELOPMENT, Apr. 2005
      • Regulation of Chk2 gene expression in lymphoid malignancies: involvement of epigenetic mechanisms in Hodgkin's lymphoma cell lines
        N Kato; H Fujimoto; A Yoda; Oishi, I; N Matsumura; T Kondo; J Tsukada; Y Tanaka; M Imamura; Y Minami
        CELL DEATH AND DIFFERENTIATION, Dec. 2004
      • The receptor tyrosine kinase Ror2 associates with and is activated by casein kinase Iepsilon.
        Shuichi Kani; Isao Oishi; Hiroyuki Yamamoto; Akinori Yoda; Hiroaki Suzuki; Akira Nomachi; Kengo Iozumi; Michiru Nishita; Akira Kikuchi; Toru Takumi; Yasuhiro Minami
        The Journal of biological chemistry, 26 Nov. 2004
      • The receptor tyrosine kinase Ror2 associates with and is activated by casein kinase Iepsilon.
        Shuichi Kani; Isao Oishi; Hiroyuki Yamamoto; Akinori Yoda; Hiroaki Suzuki; Akira Nomachi; Kengo Iozumi; Michiru Nishita; Akira Kikuchi; Toru Takumi; Yasuhiro Minami
        The Journal of biological chemistry, 26 Nov. 2004
      • Oda5p, a novel axonemal protein required for assembly of the outer dynein arm and an associated adenylate kinase
        M Wirschell; G Pazour; A Yoda; M Hirono; R Kamiya; GB Witman
        MOLECULAR BIOLOGY OF THE CELL, Jun. 2004
      • The receptor tyrosine kinase Ror2 associates with and is activated by casein kinase I epsilon
        Shuichi Kani; Isao Oishi; Hiroyuki Yamamoto; Akinori Yoda; Hiroaki Suzuki; Akira Nomachi; Akira Kikuchi; Toru Takumi; Yasuhiro Minami
        CELL STRUCTURE AND FUNCTION, May 2004
      • Structure-function analyses of protein kinase and phosphatase involved in intranuclear signaling in response to DNA damage
        Nobuyuki Onishi; Hiroko Fujimoto; Naoko Kato; Xiao Zhou Xu; Marika Horiuchi; Mutsuhiro Takekawa; Akinori Yoda; Isao Oishi; Yasuhiro Minami
        CELL STRUCTURE AND FUNCTION, May 2004
      • Expression and function of the Ror-family receptor tyrosine kinases during development: lessons from genetic analyses of nematodes, mice, and humans.
        Akinori Yoda; Isao Oishi; Yasuhiro Minami
        Journal of receptor and signal transduction research, Feb. 2003
      • Expression and function of the Ror-family receptor tyrosine kinases during development: Lessons from genetic analyses of nematodes, mice, and humans
        A Yoda; Oishi, I; Y Minami
        JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION, 2003
      • Oda5 is part of a novel axonemal complex required for outer dynein arm assembly in Chlamydomonas
        M Wirschell; G Pazour; A Yoda; M Hirono; R Kamiya; GB Witman
        MOLECULAR BIOLOGY OF THE CELL, Nov. 2002
      • ODA5, a novel gene required for outer dynein arm assembly in Chlamydomonas reinhardtii
        MB Wirschell; A Yoda; M Hirono; R Kamiya; GJ Pazour; GB Witman
        MOLECULAR BIOLOGY OF THE CELL, Nov. 2001
      • Isolation and phenotypic characterization of Chlamydomonas mutants defective in cytokinesis.
        Masafumi Hirono; Akinori Yoda
        Cell structure and Function, 1997

      External funds: Kakenhi

      • comprehensive studies on the molecular basis of early development and clonal evolution in cancer using advanced genomics.
        Grant-in-Aid for Scientific Research (S)
        Broad Section I
        Kyoto University
        Seishi Ogawa
        From 26 Jun. 2019, To 31 Mar. 2024, Project Closed
        ゲノム生物学;腫瘍生物学;全ゲノムシーケンス;単一細胞シーケンス;オルガノイド;クローン進化;腫瘍学
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H05656/
      • Cancer immunotherapy targeting neo-self antigens in splicing factor mutated cells
        Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
        Biological Sciences
        Kyoto University
        依田 成玄
        From 28 Jun. 2019, To 31 Mar. 2021, Project Closed
        AML;スプライシング;がん免疫;スプライシング因子
        https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-19H04806/
      • Development of diagnosis and treatment of novel drug targets using refractory leukemia models
        Grant-in-Aid for Scientific Research (B)
        Basic Section 52010:General internal medicine-related
        Kyoto University
        Akinori Yoda
        From 01 Apr. 2019, To 31 Mar. 2022, Project Closed
        急性骨髄性白血病;白血病;治療抵抗性;マウスモデル;GNB2
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H03560/
      • がん遺伝子産物Wip1ホスファターゼによるDNA損傷応答制御
        Grant-in-Aid for Young Scientists (B)
        Kobe University
        依田 成玄
        From 01 Apr. 2008, To 31 Mar. 2009, Project Closed
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790256/
      • Analysis of regulatory mechanisms for cell migration and cell polarity by Wnt5a and Ror2 receptor tyrosine kinase
        Grant-in-Aid for Scientific Research (B)
        Kobe University
        Yasuhiro MINAMI
        From 01 Apr. 2007, To 31 Mar. 2009, Project Closed
        Ror2受容体キナーゼ;Wnt5a;細胞移動;細胞極性;細胞骨格;Ror2受容体チロシンキナーゼ;細胞骨格再編成;浸潤突起;MMP13;Srcファミリーチロシンキナーゼ;フィラミンA;JNK;シグナル伝達
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19390076/
      • DNA損傷応答における核内構造体の動態制御機構の解析
        Grant-in-Aid for Young Scientists (B)
        Kobe University
        依田 成玄
        From 01 Apr. 2006, To 31 Mar. 2008, Project Closed
        DNA損傷応答;Chk2キナーゼ;Wip1ホスファターゼ;チェックポイント機構;悪性腫瘍
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18790222/
      • Molecular mechanism of DNA damage-induced responses and its failure by carcinogenesis
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        Kobe University
        Yasuhiro MINAMI
        From 01 Apr. 2005, To 31 Mar. 2010, Project Closed
        DNA損傷応答;シグナル伝達;がん化;Chk2キナーゼ;Wip1ホスファターゼ;Wnt5a;Ror2シグナル;がんの浸潤;癌化;14-3-3;癌の浸潤;がん原遺伝子産物;がん抑制遺伝子産物;チェックポイント機構;リン酸化・脱リン酸化;チェツクポイント機構;チェックポイントキナーゼ;がん遺伝子産物;核内シングル伝達;がんの分子標的治療;DNA損傷;Chk1キナーゼ;ATMキナーゼ;WIP1ホスファターゼ;悪性腫瘍
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17014062/
      • 癌遺伝子産物・癌抑制遺伝子産物による悪性リンパ腫の放射線感受性制御機構
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        Kobe University
        大石 勲
        From 01 Apr. 2003, To 31 Mar. 2004, Project Closed
        細胞周期;DNA損傷;シグナル伝達;Chk2 キナーゼ;Wip1 ホスファターゼ;がん遺伝子産物;がん抑制遺伝子産物;悪性リンパ腫
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15025249/
      • 細胞周期制御機構の破綻と悪性腫瘍
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        Kobe University
        南 康博
        From 01 Apr. 2003, To 31 Mar. 2005, Project Closed
        DNA損傷;細胞周期チェックポイント;シグナル伝達;Chk1キナーゼ;Chk2キナーゼ;Wip1ホスファターゼ;がん遺伝子産物;がん抑制遺伝子産物;細胞周期;Chk2 キナーゼ;Wip1 ホスファターゼ;悪性リンパ腫
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15024243/
      • 悪性リンパ腫の放射線感受性制御におけるChk2の機能
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        Kobe University
        大石 勲
        From 01 Apr. 2002, To 31 Mar. 2003, Project Closed
        セリン・スレオニンキナーゼ;蛋白質ホスファターゼ;Chk2;Wip1;DNA損傷応答;悪性リンパ腫;DNAメチル化;ヒストン脱アセチル化
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14030054/
      • 細胞周期制御機構の破綻と悪性腫瘍
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        Kobe University
        南 康博
        From 01 Apr. 2001, To 31 Mar. 2002, Project Closed
        リンパ球;H-Ras;c-Myc;HIF1;DNA損傷応答;癌抑制遺伝子産物;Chk2キナーゼ;Wip1ホスファターゼ
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13216069/
      • PDX models of rare hematopoietic malignancies for novel cancer therapies
        Grant-in-Aid for Scientific Research (B)
        Basic Section 48040:Medical biochemistry-related
        Kyoto University
        依田 成玄
        From 01 Apr. 2022, To 31 Mar. 2025, Granted
        マウスモデル;PDX;分子標的薬;白血病;急性骨髄性白血病;急性赤白血病;急性巨核球性白血病
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H02817/
      • PDX models of rare hematopoietic malignancies for novel cancer therapies
        Grant-in-Aid for Scientific Research (B)
        Basic Section 48040:Medical biochemistry-related
        Kyoto University
        依田 成玄
        From 01 Apr. 2022, To 31 Mar. 2025, Granted
        マウスモデル;PDX;分子標的薬;白血病;急性骨髄性白血病;急性赤白血病;急性巨核球性白血病
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K24079/

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