Basic Information

Email Address

• Email Address

  toya.mika.4vkyoto-u.ac.jp

Professional Memberships

• JAPAN SOCIETY FOR CELL BIOLOGY
• THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

Academic Degree

• 29 Oct. 2001

  東京大学博士（理学）

Academic Resume (Undergraduate School/Majors)

• 日本女子大学, 家政学部家政理学科生物農芸専攻, 卒業

ID,URL

• ORCID ID

  0000-0003-0999-3021

• J-Global ID

  201701019762600572

• Researcher number

  80455360

researchmap URL

• https://researchmap.jp/mika-toya

Research

Research Interests

• 細胞骨格
• 微小管
• Epithelial cells
• 分裂酵母
• 細胞構造・細胞形態と機能

Research Areas

• Life sciences, Cell biology

Papers

• A germline-specific role for unconventional components of the γ-tubulin complex in Caenorhabditis elegans.

  Nami Haruta; Eisuke Sumiyoshi; Yu Honda; Masahiro Terasawa; Chihiro Uchiyama; Mika Toya; Yukihiko Kubota; Asako Sugimoto

  Journal of cell science, 01 Jul. 2023

  
• Fission yeast Dis1 is an unconventional TOG/XMAP215 that induces microtubule catastrophe to drive chromosome pulling

  Yuichi Murase; Masahiko Yamagishi; Naoyuki Okada; Mika Toya; Junichiro Yajima; Takahiro Hamada; Masamitsu Sato

  12 Aug. 2022

  
• Tracheal motile cilia in mice require CAMSAP3 for the formation of central microtubule pair and coordinated beating

  Hiroko Saito; Fumiko Matsukawa-Usami; Toshihiko Fujimori; Toshiya Kimura; Takahiro Ide; Takaki Yamamoto; Tatsuo Shibata; Kenta Onoue; Satoko Okayama; Shigenobu Yonemura; Kazuyo Misaki; Yurina Soba; Yasutaka Kakui; Masamitsu Sato; Mika Toya; Masatoshi Takeichi

  Molecular Biology of the Cell, 01 Oct. 2021, Peer-reviewed

  
• Simplification of nutritional conditions in transformation procedures for genome editing with the CRISPR/Cas9 system for fission yeast

  Seibun Li; Mika Toya; Masamitsu Sato

  Gene, Jun. 2021, Peer-reviewed

  
• Dual Impact of a Benzimidazole Resistant β-Tubulin on Microtubule Behavior in Fission Yeast

  Mamika Minagawa; Minamo Shirato; Mika Toya; Masamitsu Sato

  Cells, 28 Apr. 2021, Peer-reviewed

  
• Tell the Difference Between Mitosis and Meiosis: Interplay Between Chromosomes, Cytoskeleton, and Cell Cycle Regulation

  Masamitsu Sato; Yasutaka Kakui; Mika Toya

  Frontiers in Cell and Developmental Biology, 08 Apr. 2021, Peer-reviewed

  
• Cyst formation in proximal renal tubules caused by dysfunction of the microtubule minus-end regulator CAMSAP3

  Yuto Mitsuhata; Takaya Abe; Kazuyo Misaki; Yuna Nakajima; Keita Kiriya; Miwa Kawasaki; Hiroshi Kiyonari; Masatoshi Takeichi; Mika Toya; Masamitsu Sato

  Scientific Reports, 12 Mar. 2021, Peer-reviewed, Corresponding author

  
• Patronin Takes a Shot at Polarity

  Masatoshi Takeichi; Mika Toya

  DEVELOPMENTAL CELL, Jul. 2016, Invited

  
• CAMSAP3 orients the apical-to-basal polarity of microtubule arrays in epithelial cells

  Mika Toya; Saeko Kobayashi; Miwa Kawasaki; Go Shioi; Mari Kaneko; Takashi Ishiuchi; Kazuyo Misaki; Wenxiang Meng; Masatoshi Takeichi

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jan. 2016, Peer-reviewed

  
• Organization of Non-centrosomal Microtubules in Epithelial Cells

  Mika Toya; Masatoshi Takeichi

  CELL STRUCTURE AND FUNCTION, 2016, Peer-reviewed, Invited

  
• The UBXN-2/p37/p47 adaptors of CDC-48/p97 regulate mitosis by limiting the centrosomal recruitment of Aurora A

  Elsa Kress; Francoise Schwager; Rene Holtackers; Jonas Seiler; Francois Prodon; Esther Zanin; Annika Eiteneuer; Mika Toya; Asako Sugimoto; Hemmo Meyer; Patrick Meraldi; Monica Gotta

  JOURNAL OF CELL BIOLOGY, May 2013, Peer-reviewed

  
• The nucleoporin Nup205/NPP-3 is lost near centrosomes at mitotic onset and can modulate the timing of this process in Caenorhabditis elegans embryos

  Virginie Hachet; Coralie Busso; Mika Toya; Asako Sugimoto; Peter Askjaer; Pierre Goenczy

  MOLECULAR BIOLOGY OF THE CELL, Aug. 2012, Peer-reviewed

  
• Pob1 Ensures Cylindrical Cell Shape by Coupling Two Distinct Rho Signaling Events During Secretory Vesicle Targeting

  Kentaro Nakano; Mika Toya; Aki Yoneda; Yukiko Asami; Akira Yamashita; Naomi Kamasawa; Masako Osumi; Masayuki Yamamoto

  TRAFFIC, Jun. 2011, Peer-reviewed

  
• A kinase-independent role for Aurora A in the assembly of mitotic spindle microtubules in Caenorhabditis elegans embryos

  Mika Toya; Masahiro Terasawa; Kayo Nagata; Yumi Tida; Asako Sugimoto

  NATURE CELL BIOLOGY, Jun. 2011, Peer-reviewed

  
• Caenorhabditis elegans ortholog of the p24/p22 subunit, DNC-3, is essential for the formation of the dynactin complex by bridging DNC-1/p150Glued and DNC-2/dynamitin

  Masahiro Terasawa; Mika Toya; Fumio Motegi; Miyeko Mana; Kuniaki Nakamura; Asako Sugimoto

  GENES TO CELLS, Nov. 2010, Peer-reviewed

  
• Imaging of Mitotic Spindle Dynamics in Caenorhabditis elegans Embryos

  Mika Toya; Yumi Iida; Asako Sugimoto

  MICROTUBULES: IN VIVO, 2010, Peer-reviewed

  
• Visualization of fluorescence-tagged proteins in fission yeast: The analysis of mitotic spindle dynamics using GFP-tubulin under the native promoter

  Masamitsu Sato; Mika Toya; Takashi Toda

  Methods in Molecular Biology, 2009, Peer-reviewed

  
• [Is spindle formation in fission yeast specific to the species?: from the viewpoint of nuclear transport and spindle pole body].

  Sato M; Toya M; Toda T

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, Mar. 2008, Peer-reviewed

  
• gamma-Tubulin complex-mediated anchoring of spindle microtubules to spindle-pole bodies requires Msd1 in fission yeast

  Mika Toya; Masamitsu Sato; Uta Haselmann; Kazuhide Asakawa; Damian Brunner; Claude Antony; Takashi Toda

  NATURE CELL BIOLOGY, Jun. 2007, Peer-reviewed

  
• Mal3, the fission yeast EB1 homologue, cooperates with Bub1 spindle checkpoint to prevent monopolar attachment

  K Asakawa; M Toya; M Sato; M Kanai; K Kume; T Goshima; MA Garcia; D Hirata; T Toda

  EMBO REPORTS, Dec. 2005, Peer-reviewed

  
• Identification and functional analysis of the gene for type I myosin in fission yeast

  M Toya; F Motegi; K Nakano; Mabuchi, I; M Yamamoto

  GENES TO CELLS, Mar. 2001, Peer-reviewed

  
• Fission yeast Pob1p, which is homologous to budding yeast Boi proteins and exhibits subcellular localization close to actin patches, is essential for cell elongation and separation

  M Toya; Y Iino; M Yamamoto

  MOLECULAR BIOLOGY OF THE CELL, Aug. 1999, Peer-reviewed

  
• Fission yeast protein kinase C gene homologues are required for protoplast regeneration: A functional link between cell wall formation and cell shape control

  Hiromi Kobori; Takashi Toda; Hiroko Yaguchi; Mika Toya; Mitsuhiro Yanagida; Masako Osumi

  Journal of Cell Science, May 1994, Peer-reviewed

  

External funds: Kakenhi

• Microtubule-mediated regulation of somatic-germ cell communication that underlies follicle maturation

  Grant-in-Aid for Scientific Research (C)

  Basic Section 44010:Cell biology-related

  Kyoto University

  戸谷 美夏

  From 01 Apr. 2025, To 31 Mar. 2028, Granted

  微小管マイナス端;変異マウス;卵胞成熟;細胞間輸送;Transzonal projection

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25K09635/
• Molecular mechanisms of cystic kidney formation caused by non-centrosomal microtubule dysfunction

  Grant-in-Aid for Scientific Research (C)

  Basic Section 44010:Cell biology-related

  Waseda University

  Mika Toya

  From 01 Apr. 2020, To 31 Mar. 2023, Project Closed

  上皮細胞;微小管編成;腎臓;嚢胞腎;微小管マイナス端;CAMSAP3;変異マウス;遺伝子発現解析;ノックアウトマウス;非中心体微小管

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K06645/
• Non-centrosomal microtubules that control the structure and function of kidney tubules

  Grant-in-Aid for Scientific Research (C)

  Waseda University

  Mika TOYA

  From 01 Apr. 2017, To 31 Mar. 2020, Project Closed

  上皮細胞;微小管編成;腎臓;嚢胞腎;微小管マイナス端;非中心体微小管;CAMSAP3;ノックアウトマウス;CAMSAP3/Nezha;腎嚢胞;細胞・組織;微小管;腎尿細管

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K07397/
• Organization and function of non-centrosomal microtubules array in polarized epithelial cells

  Grant-in-Aid for Scientific Research (C)

  Institute of Physical and Chemical Research

  Mika Toya

  From 01 Apr. 2013, To 31 Mar. 2016, Project Closed

  極性上皮細胞;微小管編成;微小管マイナス端;CAMSAP3/Nezha;変異マウス;小腸;Caco-2細胞;立体培養系;ノックアウトマウス;三次元培養系;Nezha/CAMSAP3

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25440094/
• Analysis for the two distinct pathways to form mitotic spindles in C. elegans embryos

  Grant-in-Aid for Scientific Research (C)

  The Institute of Physical and Chemical Research

  Mika TOYA

  From 01 Apr. 2009, To 31 Mar. 2012, Project Closed

  紡錘体形成;微小管制御;オーロラキナーゼA;γチューブリン;線虫初期胚;ライブイメージング;RNAi;γ-チューブリン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21570209/

Education

Teaching subject(s)

• From 01 Apr. 2026, To 31 Mar. 2027

  Fundamental Chemical Experiments

  N308, Fall, Institute for Liberal Arts and Sciences, 2