Basic Information

Email Address

• Email Address

  yamaguchi.tomoko.5kkyoto-u.ac.jp

Academic Degree

• 25 Mar. 2019

  大阪大学修士（生命機能学）
• 24 Mar. 2022

  大阪大学博士（理学）

Academic Resume (Undergraduate School/Majors)

• 大阪大学, 理学部物理学科, 卒業

Research History

• From Apr. 2023, To Present

  Graduate school and faculty of pharmaceutical science, Kyoto University, 構造生物薬学分野, Assistant Professor, Ph.D.
• From Apr. 2022, To Mar. 2023

  Charles University, Faculty of Science, post doctoral researcher, Ph.D.
• From Apr. 2022, To Mar. 2023

  Tokyo Institute of Technology, Earth-Life Science Institute, JSPS research fellow, Ph.D.
• From Apr. 2021, To Mar. 2022

  Osaka University, Graduate School of Frontier Biosciences, Research Fellowship for Young Scientists (DC2)
• From Apr. 2019, To Mar. 2021

  RIKEN, RIKEN center for Biosystems Dynamics Research, Junior Research Associate
• From Apr. 2020, To Sep. 2020

  Osaka Institute of Technology, ロボティクス&デザイン工学部, 非常勤講師

ID,URL

• ORCID ID

  0000-0001-9482-8738

• J-Global ID

  202301002994907949

• Researcher number

  60978964

researchmap URL

• https://researchmap.jp/supercalifragilistic

Research

Research Interests

• biophysics
• origins of life
• bacterial flagellum
• membrane protein
• structural biology
• Cryo-EM

Research Areas

• Life sciences, Structural biochemistry, Cryo-EM structural analysis for protein, bacterial flagellar motor, membrane protein, ABC transporter

Papers

• The interplay between peptides and RNA is critical for protoribosome compartmentalization and stability

  Simone Codispoti; Tomoko Yamaguchi; Mikhail Makarov; Valerio G Giacobelli; Martin Mašek; Michal H Kolář; Alma Carolina Sanchez Rocha; Kosuke Fujishima; Giuliano Zanchetta; Klára Hlouchová

  Nucleic Acids Research, 28 Sep. 2024, Peer-reviewed, Lead author

  
• Purification and CryoEM Image Analysis of the Bacterial Flagellar Filament.

  Tomoko Yamaguchi; Tomoko Miyata; Fumiaki Makino; Keiichi Namba

  Methods in molecular biology (Clifton, N.J.), 2023

  
• Structures of multisubunit membrane complexes with the CRYO ARM 200.

  Christoph Gerle; Jun-Ichi Kishikawa; Tomoko Yamaguchi; Atsuko Nakanishi; Orkun Çoruh; Fumiaki Makino; Tomoko Miyata; Akihiro Kawamoto; Ken Yokoyama; Keiichi Namba; Genji Kurisu; Takayuki Kato

  Microscopy (Oxford, England), 06 Oct. 2022

  
• Structure of the molecular bushing of the bacterial flagellar motor.

  Tomoko Yamaguchi; Fumiaki Makino; Tomoko Miyata; Tohru Minamino; Takayuki Kato; Keiichi Namba

  Nature communications, 22 Jul. 2021

  
• Structural and Functional Comparison of Salmonella Flagellar Filaments Composed of FljB and FliC.

  Tomoko Yamaguchi; Shoko Toma; Naoya Terahara; Tomoko Miyata; Masamichi Ashihara; Tohru Minamino; Keiichi Namba; Takayuki Kato

  Biomolecules, 06 Feb. 2020

  

Awards

• 08 Oct. 2019

  RIKEN summer school 2019
• 28 Feb. 2021

  Biomolecules 10th Anniversary Best Cover Awards
• 29 May 2021

  優秀発表賞
• 27 Nov. 2021

  第6回日本生物物理学会学生発表賞
• 24 May 2019

  FBS Retreat 2019 2nd prize winner of questioner Award

External funds: Kakenhi

• Cryo-EMによるABCB1トランスポーターの非特異的な多剤排出のメカニズムの解明

  Grant-in-Aid for Research Activity Start-up

  0801:Pharmaceutical sciences and related fields

  Kyoto University

  山口 智子

  From 31 Aug. 2023, To 31 Mar. 2025, Granted

  ABCB1トランスポーター;多剤排出;立体構造解析;クライオ電子顕微鏡

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K19426/

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  Laboratory Practice in Basic Analytical Chemistry and Structural Biology

  4202, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar in Basic Biophysical Chemistry

  2302, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Physical Chemistry for Drug Discovery

  1217, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Physical Chemistry for Drug Discovery

  8101, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Pharmaceutical Sciences

  6002, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Pharmaceutical Laboratory I : Analytical and Physical Chemistry

  C901, Spring, Faculty of Pharmaceutical Sciences, 3
• From 01 Apr. 2024, To 31 Mar. 2025

  Research in Basic Biophysical Chemistry

  3202, Year-long, Graduate School of Pharmaceutical Sciences, 4