Basic Information

Professional Memberships

• Japanese Society for Immunology

Academic Degree

• (China Agriculture University)
• (Kyoto University)

Language of Instruction

• Japanese
• English

ID,URL

• J-Global ID

  202101000810607070

• Researcher number

  00896631

researchmap URL

• https://researchmap.jp/cynthiaxy

Research

Research Areas

• Life sciences, Cell biology
• Life sciences, Immunology

Papers

• Thymic Development of a Unique Bone Marrow-Resident Innate-like T Cell Subset with a Potent Innate Immune Function.

  Ryusuke Yamamoto; Yan Xu; Satoshi Ikeda; Kentaro Sumida; Hiroki Tanaka; Katsuto Hozumi; Akifumi Takaori-Kondo; Nagahiro Minato

  Journal of immunology (Baltimore, Md. : 1950), 01 Jul. 2019

  
• Sipa1 deficiency unleashes a host-immune mechanism eradicating chronic myelogenous leukemia-initiating cells.

  Yan Xu; Satoshi Ikeda; Kentaro Sumida; Ryusuke Yamamoto; Hiroki Tanaka; Nagahiro Minato

  Nature communications, 02 Mar. 2018

  Access this paper :

  

Presentations

• A latent role of Sipa1 deficient mesenchymal stroma cells revealed in tumor resistant.

  Yan Xu; Kentaro Sumida; Ryuhei Kawakami; Masakazu Hattori; Nagahiro Minato

  Keystone Symposia Conference | Cancer Metastasis and The Resistant Tumor Microenvironment conference, 10 May 2023

  
• Sipa1 which controls stromal activation and T-cell recruitment in cancer tissue may be a new checkpoint component for cancer immunity

  17th International Congress of Immunology, 20 Oct. 2019

  
• Sipa1 deficiency unleashes a potent anti-tumor immune mechanism in chronic myelogenous leukemia

  Keystone Symposia Conference | Cancer Metastasis: The Role of Metabolism, Immunity and the Microenvironment

  
• Sipa1 deficiency unleashes a host-immune mechanism eradicating chronic myelogenous leukemia-initiating cells

  The 47th Annual Meeting of the Japanease Society for Immunology, 12 Dec. 2018

  

External funds: Kakenhi

• The mechanism of resistance to cancer uncovered by Sipa1 deficiency

  Grant-in-Aid for Early-Career Scientists

  Basic Section 49070:Immunology-related

  Kyoto University

  YAN XU

  From 01 Apr. 2021, To 31 Mar. 2024, Project Closed

  Sipa1;tumor;MSCs;IFNγ;STAT１;mesenchymal stroma cells;T cell infiltration;Tumor microenvironment;Cancer immunotherapy

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K15466/