Basic Information

Professional Memberships

• The Molecular Biology Society of Japan
• The Japanese Biochemical Society
• The Japanese Cancer Association

Academic Degree

• 京都大学修士（農学）
• 京都大学博士（農学）

Research History

• From Jun. 2025, To Sep. 2025

  MRC Laboratory of Medical Sciences, Imperial College London, United Kingdom, Visiting Researcher
• From Feb. 2025, To Mar. 2025

  Brighton and Sussex Medical School, United Kingdom, Visiting Researcher
• From Jul. 2026, To Present

  Kyoto University, Graduate School of Agriculture Division of Applied Life Sciences, Assistant Professor
• From Jul. 2026, To Present

  The University of Osaka, Institute for Protein Research, Visiting Researcher
• From Apr. 2020, To Jun. 2026

  The University of Osaka, Institute for Protein Research, Assistant Professor
• From Oct. 2019, To Mar. 2020

  The University of Osaka, Institute for Protein Research, Research Fellow
• From 2018

  Molecular Health GmbH (Heidelberg, Germany)

Language of Instruction

• Japanese
• English

ID,URL

• ORCID ID

  0000-0003-0791-8933

• J-Global ID

  202001003663280070

researchmap URL

• https://researchmap.jp/a-ichikawa-nagasato

Research

Research Areas

• Life sciences, Molecular biology, 生化学/ 細胞生物学/ 腫瘍生物学/ システム生物学

Papers

• Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

  Ririn Rahmala Febri; Ayaka Nagasato‐Ichikawa; Keita Iida; Shuhei Kimura; Akira Imamoto; Mariko Okada

  FEBS Letters, 21 Aug. 2026, Peer-reviewed

  
• Dual RAF inhibition outperforms RAF-MEK combinations for suppressing ERK signaling in KRAS mutant cells

  *Hiroaki Imoto; *Nora Rauch; *Ayaka Ichikawa Nagasato; Mariko Okada; Walter Kolch; Oleksii S. Rukhlenko; Boris N. Kholodenko

  npj Systems Biology and Applications, 15 Apr. 2026, Peer-reviewed, Lead author

  
• Network structures and parameters in multiscale modeling in ErbB signaling networks

  Ai Shinobu; Ayaka Nagasato-Ichikawa; Mariko Okada

  Current Opinion in Cell Biology, Feb. 2026, Peer-reviewed, Invited

  
• The receptor tyrosine kinase ErbB2/HER2 governs CDK4 inhibitor sensitivity, timing, and irreversibility of the G1/S transition

  Ayaka Nagasato-Ichikawa; Ken Murakami; Kazuhiro Aoki; Mariko Okada

  Journal of Biological Chemistry, Dec. 2025, Peer-reviewed, Lead author

  
• Stiff extracellular matrix activates the transcription factor ATF5 to promote the proliferation of cancer cells

  Seiichiro Ishihara; Atsushi Enomoto; Akihiro Sakai; Tadashi Iida; Shoichiro Tange; Noriyuki Kioka; Akihiro Nukuda; Ayaka Ichikawa Nagasato; Motoaki Yasuda; Takashi Tokino; Hisashi Haga

  iScience, Mar. 2025, Peer-reviewed

  
• ErbB2/HER2 governs CDK4 inhibitor sensitivity and timing and irreversibility of G1/S transition by altering c-Myc and cyclin D function

  Ayaka Nagasato-Ichikawa; Ken Murakami; Kazuhiro Aoki; Mariko Okada

  07 Feb. 2025, Lead author

  
• NFκB dynamics‐dependent epigenetic changes modulate inflammatory gene expression and induce cellular senescence

  Sho Tabata; Keita Matsuda; Shou Soeda; Kenshiro Nagai; Yoshihiro Izumi; Masatomo Takahashi; Yasutaka Motomura; Ayaka Ichikawa Nagasato; Kazuyo Moro; Takeshi Bamba; Mariko Okada

  The FEBS Journal, 16 Jul. 2024, Peer-reviewed

  
• NFκB nuclear dynamics orchestrate inflammatory aging

  Sho Tabata; Keita Matsuda; Kenshiro Nagai; Yoshihiro Izumi; Masatomo Takahashi; Yasutaka Motomura; Ayaka Ichikawa Nagasato; Shuichi Shimma; Kazuyo Moro; Takeshi Bamba; Mariko Okada

  bioRxiv, 18 Apr. 2023

  
• Nuclear NFκB Activity Balances Purine Metabolism in Cellular Senescence

  Sho Tabata; Keita Matsuda; Kenshiro Nagai; Yoshihiro Izumi; Masatomo Takahashi; Yasutaka Motomura; Ayaka Ichikawa Nagasato; Shuichi Shimma; Kazuyo Moro; Takeshi Bamba; Mariko Okada

  18 Apr. 2023

  
• Vinexin family (SORBS) proteins play different roles in stiffness-sensing and contractile force generation.

  Takafumi Ichikawa; Masahiro Kita; Tsubasa S Matsui; Ayaka Ichikawa Nagasato; Tomohiko Araki; Shian-Huey Chiang; Takuhito Sezaki; Yasuhisa Kimura; Kazumitsu Ueda; Shinji Deguchi; Alan R Saltiel; Noriyuki Kioka

  Journal of cell science, 15 Oct. 2017, Peer-reviewed

  
• The distribution of vinculin to lipid rafts plays an important role in sensing stiffness of extracellular matrix.

  Ayaka Ichikawa Nagasato; Hiroshi Yamashita; Michinori Matsuo; Kazumitsu Ueda; Noriyuki Kioka

  Bioscience, biotechnology, and biochemistry, Jun. 2017, Peer-reviewed, Lead author

  

Misc.

• Understanding the ligand-specific of the HER2 signaling network in cell cycle G1/S transition

  Ririn Rahmala Febri, Ayaka Ichikawa, Mariko Okada

  NTU-OsakaU Bilateral Symposium on Systems Biology in Human Disease, NTU, Taiwan, Apr. 2024, Peer-reviewed

  
• Understanding the ligand-specific of the HER2 signaling network in cell cycle G1/S transition

  Ririn Rahmala Febri, 市川 彩花, 岡田 眞里子

  第46回 日本分子生物学会年会, 神戸, Dec. 2023, Peer-reviewed

  
• Unraveling the mechanisms of drug resistance in the MAPK pathway using structure-based modeling

  Hiroaki Imoto, Nora Rauch, Ayaka Ichikawa, Mariko Okada, Oleksii S. Rukhlenko, Boris N. Kholodenko

  The 61st Annual Meeting of the Biophysical Society of Japan, Aichi, Japan, Nov. 2023, Peer-reviewed

  
• 細胞外基質の硬さに応じた乳腺上皮細胞の嚢胞・管腔形成に与えるビンキュリンの効果

  今井まり子; 市川(長里)彩花; 植田和光; 木岡紀幸

  日本農芸化学会2016年度(平成28年度)大会, 札幌, Mar. 2016, Peer-reviewed

  
• コラーゲンが上皮細胞の嚢胞と管腔形成に及ぼす影響

  今井まり子; 市川(長里)彩花; 植田和光; 木岡紀幸

  2015年度 日本農芸化学会中部・関西支部合同大会, 富山, Sep. 2015, Peer-reviewed

  
• Lipid rafts is involved in vinculin-vinexin-mediated mechanosensing of ECM stiffness

  Ayaka Nagasato, Takafumi Ichikawa, Hiroshi Yamashita, Mito Kuroda, Kazumitsu Ueda and Noriyuki Kioka

  2014 Gordon Conference "Signaling by Adhesion Receptors, Lewiston, USA, Jun. 2014, Peer-reviewed

  
• Vinexin-dependent distribution of vinculin to lipid rafts stabilizes vinculin at focal adhesions

  Hiroshi Yamashita; Ayaka Nagasato; Takafumi Ichikawa; Michinori Matsuo; Kazumitsu Ueda; Noriyuki Kioka

  2012 Annual Meeting of The American Society for Cell Biology, San Francisco, USA, Dec. 2012, Peer-reviewed

  

Presentations

• がん細胞の増殖と休眠を分ける分子機構の定量的解明と数理予測

  第20回 応生トピックスセミナー, 05 Oct. 2026, Invited

  
• 乳がん細胞におけるErbB2受容体の発現変化によるE2F活性制御と細胞運命分岐の数理解析

  市川彩花; 岡田眞里子

  第26回日本蛋白質科学会年会ワークショップ, Jun. 2026, Invited

  
• なぜ細胞まるごとシミュレーションが必要なのか？

  第48回日本分子生物学会年会フォーラム, Dec. 2025, Invited

  
• The receptor tyrosine kinase ErbB2/HER2 governs CDK4 inhibitor sensitivity, timing and irreversibility of the G1/S transition

  Ayaka Ichikawa

  Seminar at MRC Laboratory of Medical Sciences (LMS), Imperial College London, UK, Jul. 2025, Invited

  
• ErbB2 governs CDK4 inhibitor sensitivity, and timing and irreversibility of G1/S cell cycle transition

  Ayaka Ichikawa

  Seminar at Brighton and Sussex Medical School, University of Sussex, Brighton, United Kingdom, Mar. 2025, Invited

  
• ErbB2/HER2 governs CDK4 inhibitor sensitivity and timing and irreversibility of G1/S transition by altering c-Myc and cyclin D function.

  Ayaka Ichikawa

  IPR International Conference 2025 in Awaji Island, Jan. 2025

  
• ErbB2／HER2 modulates Cyclin D1 and c-Myc dependency at G1/S transition, impacting CDK4 inhibitor sensitivity.

  Ayaka Ichikawa; Ken Murakami; Kazuhiro Aoki; Mariko Okada

  The 83rd Annual Meeting of the Japanese Cancer Association, Sep. 2024

  
• ErbB2/HER2 expression level determines Cyclin D1 and c-Myc dependency at G1/S transition and CDK4 inhibitor sensitivity

  Ayaka Ichikawa, Ken Murakami, Kazuhiro Aoki, Mariko Okada

  FASEB Science Reaserch Conferences (SRC) "Dynamics and Encoding in Cell Signaling", The Niagara Falls Convention Center, USA, Jul. 2024

  
• ErbB2／HER2 modulates Cyclin D1 and c-Myc dependency at G1/S transition, impacting CDK4 inhibitor sensitivity

  Ayaka Ichikawa; Ken Murakami; Kazuhiro Aoki; Mariko Okada

  9th Conference on Systems Biology of Mammalian Cells, Leipzig, Germany, May 2024

  
• Role of ErbB2 receptor expression on cell cycle progression and quiescence via Cyclin D1 and c-Myc

  Ayaka Ichikawa, Ken Murakami, Kazuhiro Aoki, Mariko Okada

  第96回日本生化学大会, 福岡, Nov. 2023

  
• Regulatory mechanism of G1/S cell cycle transition via ErbB signaling network.

  Ayaka Ichikawa

  Japan-Korea Bilateral Symposium between IPR and SNU on Structure and Folding of Disease Related Proteins, Seoul National University, Korea, Jan. 2023

  
• 細胞周期G1/S移行におけるErbBシグナル―CDK4クロストーク制御の解明

  市川彩花; 村上賢; 青木一洋; 岡田眞里子

  第45回日本分子生物学会年会, 千葉, Dec. 2022

  
• ErbBシグナル伝達系を介した細胞周期G1/S移行の制御機構

  市川彩花; 村上賢; 青木一洋; 岡田眞里子

  第95回日本生化学会大会, 愛知, Nov. 2022

  
• The Distribution of Vinculin to Lipid Rafts Plays an Important Role in Sensing Stiffness of Extracellular Matrix

  Ayaka Ichikawa Nagasato; Hiroshi Yamashita; Michinori Matsuo; Kazumitsu Ueda; Noriyuki Kioka

  Mechanical Forces in Biology, EMBL, Heidelberg, Germany, Jul. 2017

  
• ビンキュリンの脂質ラフト局在化は細胞遊走能の細胞外マトリックスの硬さ依存性に必要である

  長里彩花; 山下寛; 松尾道憲; 植田和光; 木岡紀幸

  第38回 日本分子生物学会年会・第88回 日本生化学会大会合同大会, 神戸, Dec. 2015

  
• ビンキュリンの脂質ラフト局在化は細胞遊走能の細胞外マトリックスの硬さ依存性に必要である

  長里彩花; 山下寛; 松尾道憲; 植田和光; 木岡紀幸

  平成27年度 がん若手研究者ワークショップ, 長野, Sep. 2015

  
• 細胞外マトリックスの硬さに応じたビンキュリンの脂質ラフト局在化は細胞の遊走能に影響する

  長里彩花

  第1回細胞生物若手の会, 東京, Jun. 2015

  
• Distribution of vinculin to lipid rafts is involved in sensing ECM stiffness

  Ayaka Nagasato; Hiroshi Yamashita; Michinori Matsuo; Kazumitsu Ueda; Noriyuki Kioka

  2014 Annual Meeting of The American Society for Cell Biology, Philadelphia, USA, Dec. 2014

  
• 接着斑タンパク質ビンキュリンによる細胞外基質の硬さ感知には脂質ラフト局在化が必要である

  長里彩花; 山下寛; 松尾道憲; 植田和光; 木岡紀幸

  第87回 日本生化学会大会, 京都, Oct. 2014

  
• ECMの硬さ感知に応答したビンキュリンの脂質ラフトへの移行

  長里彩花; 山下寛; 市川尚文; 松尾道憲; 植田和光; 木岡紀幸

  第9回メカノセンシング研究会, 神戸, Mar. 2014

  
• 接着斑タンパク質ビンキュリンによる細胞外基質の硬さ感知には、ビンキュリンの脂質ラフト局在化が必要である

  長里彩花; 山下寛; 市川尚文; 松尾道憲; 植田和光; 木岡紀幸

  日本農芸化学会2014年度(平成26年度)大会, 東京, Mar. 2014

  
• PIP2- and vinexin-dependent distribution of vinculin to lipid rafts stabilizes vinculin at focal adhesions

  長里彩花, 山下寛, 松尾道憲, 植田和光, 木岡紀幸

  第65回 日本細胞生物学会大会, 愛知, Jun. 2013

  
• PIP2-dependent distribution of vinculin to lipid rafts stabilizes vinculin at focal adhesions

  Ayaka Nagasato; Hiroshi Yamashita; Michinori Matsuo; Kazumitsu Ueda; Noriyuki Kioka

  The Fourteenth International Membrane Research Forum, Kyoto University, Japan, Mar. 2013

  
• PIP2-and vinexin-dependent distribution of vinculin to lipid rafts stabilizes vinculin at focal adhesions

  Ayaka Nagasato; Hiroshi Yamashita; Michinori Matsuo; Kazumitsu Ueda; Noriyuki Kioka

  Cell-Material Integration & Biomaterials Science, Kyoto University, Mar. 2013

  
• 接着斑タンパク質ビンキュリンの脂質ラフト局在化にはPIP2との結合が必要である

  長里彩花; 山下寛; 市川尚文; 松尾道憲; 植田和光; 木岡紀幸

  日本農芸化学会2013年度(平成25年度)大会, 仙台, Mar. 2013

  
• ビンキュリンはビネキシン依存的に脂質ラフトに局在化する

  長里彩花, 山下寛, 市川尚文, 植田和光, 木岡紀幸

  日本農芸化学会2012年度(平成24年度)大会, 京都, Mar. 2012

  

Awards

• 16 Oct. 2014

  若手優秀発表賞（第８７回日本生化学会大会）
• 15 Mar. 2018

  B.B.B.論文賞（公益社団法人日本農芸化学会）

External funds: Kakenhi

• Quantitative analysis of the G1/S transition mechanism underlying ErbB2 signaling in the process of breast cancer proliferation

  Grant-in-Aid for Early-Career Scientists

  Basic Section 50010:Tumor biology-related

  The University of Osaka

  市川 彩花

  From 01 Apr. 2025, To 31 Mar. 2028, Granted

  乳がん;細胞周期;ErbB2

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25K18877/
• Elucidation of extracellular matrix stiffness-dependent cell proliferation signaling pathways in breast cancer subtypes.

  Grant-in-Aid for Early-Career Scientists

  Basic Section 50010:Tumor biology-related

  Osaka University

  Ayaka Ichikawa

  From 01 Apr. 2021, To 31 Mar. 2024, Project Closed

  乳がん;がん微小環境;転写制御;細胞増殖;ErbBシグナル伝達系

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K15503/

Academic, Social Contribution

Academic Contribution

• IPR Seminar | オミクス解析における実験と数理の協働

  Planning, management, etc., Panel moderator

  飯田 渓太, 市川 彩花, From 15 Jan. 2021

  
• 2020年度若手技術セミナー

  Planning, management, etc.

  市川 彩花, 岡橋 伸幸, 和泉 自泰, 梅山 大地, 大野 聡, 堀之内 貴明, 飯田 渓太, From 2020

  

Social Contribution

• APRU Asia Pacific Woman in Leadership (APWiL) program

  Logistic support