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Miyazaki, Masaki
Institute for Life and Medical Sciences (LiMe) Associate Professor
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Last Updated :2025/06/20
Basic Information
Affiliated programs (koza)
Professional Memberships
Academic Degree
Research History
- From Apr. 2022, To Present京都大学 医生物学研究所 再生免疫学 准教授
- From Oct. 2017, To Mar. 2022京都大学 ウイルス・再生医科学研究所 再生免疫学 准教授
- From Jan. 2015, To Sep. 2017京都大学 再生医科学研究所 再生免疫学, 助教
- From May 2010, To Dec. 2014University of California San Diego, associate project scientist
- From Feb. 2005, To Jun. 2010広島大学医歯薬学総合研究科, 助教
- From Apr. 1997, To Mar. 2000国家公務員共済組合 虎の門病院, 内科レジデント
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Last Updated :2025/06/20
Research
Research Areas
Papers
- The Function of E2A in B-Cell DevelopmentMasaki Miyazaki; Kazuko MiyazakiAdvances in Experimental Medicine and Biology, 2024
- The transcription factor RORα is required for the development of type 1 innate lymphoid cells in adult bone marrowShinya Abe; Moe Kagao; Takuma Asahi; Ryoma Kato; Shizue Tani-ichi; Akihiro Shimba; Riki Ishibashi; Hitoshi Miyachi; Satsuki Kitano; Masaki Miyazaki; Hans-Reimer Rodewald; Fumiko Toyoshima; Koichi IkutaThe Journal of Immunology, 01 Apr. 2025
- A feedback amplifier circuit with Notch and E2A orchestrates T-cell fate and suppresses the innate lymphoid cell lineages during thymic ontogeny.Kazuko Miyazaki; Kenta Horie; Hitomi Watanabe; Reiko Hidaka; Rinako Hayashi; Norihito Hayatsu; Kentaro Fujiwara; Rei Kuwata; Takuya Uehata; Yotaro Ochi; Makoto Takenaka; Risa Karakida Kawaguchi; Koichi Ikuta; Osamu Takeuchi; Seishi Ogawa; Katsuto Hozumi; Georg A Holländer; Gen Kondoh; Taishin Akiyama; Masaki MiyazakiGenes & development, 04 Feb. 2025
- The E-Id Protein Axis Specifies the Innate and AdaptLymphoid Branches of the Immune SystemMasaki MiyazakiImmunity, 16 May 2017
- Regulation of lymphoid-myeloid lineage bias through Regnase-1/3-mediated control of Nfkbiz.Takuya Uehata; Shinnosuke Yamada; Daisuke Ori; Alexis Vandenbon; Amir Giladi; Adam Jelinski; Yasuhiro Murakawa; Hitomi Watanabe; Kazuhiro Takeuchi; Kazunori Toratani; Takashi Mino; Hisanori Kiryu; Daron M Standley; Tohru Tsujimura; Tomokatsu Ikawa; Gen Kondoh; Markus Landthaler; Hiroshi Kawamoto; Hans-Reimer Rodewald; Ido Amit; Ryo Yamamoto; Masaki Miyazaki; Osamu TakeuchiBlood, 03 Nov. 2023
- Hematopoietic cell-derived IL-15 supports NK cell development in scattered and clustered localization within the bone marrow.Shinya Abe; Takuma Asahi; Takahiro Hara; Guangwei Cui; Akihiro Shimba; Shizue Tani-Ichi; Kohei Yamada; Kazuko Miyazaki; Hitoshi Miyachi; Satsuki Kitano; Naotoshi Nakamura; Junichi Kikuta; Alexis Vandenbon; Masaki Miyazaki; Ryo Yamada; Toshiaki Ohteki; Masaru Ishii; Veronika Sexl; Takashi Nagasawa; Koichi IkutaCell reports, 26 Sep. 2023
- Liver type 1 innate lymphoid cells lacking IL-7 receptor are a native killer cell subset fostered by parenchymal niches.Takuma Asahi; Shinya Abe; Guangwei Cui; Akihiro Shimba; Tsukasa Nabekura; Hitoshi Miyachi; Satsuki Kitano; Keizo Ohira; Johannes M Dijkstra; Masaki Miyazaki; Akira Shibuya; Hiroshi Ohno; Koichi IkutaeLife, 22 Jun. 2023
- The E-Id axis specifies adaptive and innate lymphoid lineage cell fatesMasaki Miyazaki; Kazuko MiyazakiThe Journal of Biochemistry, 24 Aug. 2022
- The E-Id Axis Instructs Adaptive Versus Innate Lineage Cell Fate Choice and Instructs Regulatory T Cell DifferentiationReiko Hidaka; Kazuko Miyazaki; Masaki MiyazakiFrontiers in Immunology, 06 May 2022
- The Interplay Between Chromatin Architecture and Lineage-Specific Transcription Factors and the Regulation of Rag Gene ExpressionKazuko Miyazaki; Masaki MiyazakiFrontiers in Immunology, 16 Mar. 2021
- Identification of Zfp521/ZNF521 as a cooperative gene for E2A-HLF to develop acute B-lineage leukemiaN. Yamasaki; K. Miyazaki; A. Nagamachi; R. Koller; H. Oda; M. Miyazaki; T. Sasaki; Z-i Honda; L. Wolff; T. Inaba; H. HondaONCOGENE, Apr. 2010, Peer-reviewed
- The Evolution of Rag Gene Enhancers and Transcription Factor E and Id Proteins in the Adaptive Immune SystemGenki Yoshikawa; Kazuko Miyazaki; Hiroyuki Ogata; Masaki MiyazakiInternational Journal of Molecular Sciences, 31 May 2021
- The transcription factor E2A activates multiple enhancers that drive Rag expression in developing T and B cells.Kazuko Miyazaki; Hitomi Watanabe; Genki Yoshikawa; Kenian Chen; Reiko Hidaka; Yuki Aitani; Kai Osawa; Rie Takeda; Yotaro Ochi; Shizue Tani-Ichi; Takuya Uehata; Osamu Takeuchi; Koichi Ikuta; Seishi Ogawa; Gen Kondoh; Yin C Lin; Hiroyuki Ogata; Masaki MiyazakiScience immunology, 04 Sep. 2020
- Long non-coding RNA MANCR is a target of BET bromodomain protein BRD4 and plays a critical role in cellular migration and invasion abilities of prostate cancer.Masayuki Nagasawa; Kosuke Tomimatsu; Koji Terada; Kenta Kondo; Kazuko Miyazaki; Masaki Miyazaki; Daisuke Motooka; Daisuke Okuzaki; Tetsuya Yoshida; Susumu Kageyama; Hiroshi Kawamoto; Akihiro Kawauchi; Yasutoshi AgataBiochemical and biophysical research communications, 21 May 2020
- NK Cell Alloreactivity against KIR-Ligand-Mismatched HLA-Haploidentical Tissue Derived from HLA Haplotype-Homozygous iPSCs.Hiroshi Ichise; Seiji Nagano; Takuya Maeda; Masaki Miyazaki; Yuki Miyazaki; Hiroto Kojima; Nobuyo Yawata; Makoto Yawata; Hidenori Tanaka; Hiroh Saji; Kyoko Masuda; Hiroshi KawamotoStem cell reports, 12 Sep. 2017
- The E-Id Protein Axis Specifies Adaptive Lymphoid Cell Identity and Suppresses Thymic Innate Lymphoid Cell Development.Masaki Miyazaki; Kazuko Miyazaki; Kenian Chen; Yi Jin; Jacob Turner; Amanda J Moore; Rintaro Saito; Kenichi Yoshida; Seishi Ogawa; Hans-Reimer Rodewald; Yin C Lin; Hiroshi Kawamoto; Cornelis MurreImmunity, 16 May 2017
- Id3 Orchestrates Germinal Center B Cell Development.Shuwen Chen; Masaki Miyazaki; Vivek Chandra; Kathleen M Fisch; Aaron N Chang; Cornelis MurreMolecular and cellular biology, 15 Oct. 2016
- The E-Id protein axis modulates the activities of the PI3K-AKT-mTORC1-Hif1a and c-myc/p19Arf pathways to suppress innate variant TFH cell development, thymocyte expansion, and lymphomagenesis.Masaki Miyazaki; Kazuko Miyazaki; Shuwen Chen; Vivek Chandra; Keisuke Wagatsuma; Yasutoshi Agata; Hans-Reimer Rodewald; Rintaro Saito; Aaron N Chang; Nissi Varki; Hiroshi Kawamoto; Cornelis MurreGenes & development, 15 Feb. 2015
- Id2 and Id3 maintain the regulatory T cell pool to suppress inflammatory disease.Masaki Miyazaki; Kazuko Miyazaki; Shuwen Chen; Manami Itoi; Marina Miller; Li-Fan Lu; Nissi Varki; Aaron N Chang; David H Broide; Cornelis MurreNature immunology, Aug. 2014
- The establishment of B versus T cell identity.Kazuko Miyazaki; Masaki Miyazaki; Cornelis MurreTrends in immunology, May 2014
- Global changes in the nuclear positioning of genes and intra- and interdomain genomic interactions that orchestrate B cell fate.Yin C Lin; Christopher Benner; Robert Mansson; Sven Heinz; Kazuko Miyazaki; Masaki Miyazaki; Vivek Chandra; Claudia Bossen; Christopher K Glass; Cornelis MurreNature immunology, Dec. 2012
- β-Selection-induced proliferation is required for αβ T cell differentiation.Taras Kreslavsky; Michael Gleimer; Masaki Miyazaki; Yoon Choi; Etienne Gagnon; Cornelis Murre; Piotr Sicinski; Harald von BoehmerImmunity, 16 Nov. 2012
- E2A and CBP/p300 act in synergy to promote chromatin accessibility of the immunoglobulin κ locus.Shuji Sakamoto; Kousho Wakae; Yuki Anzai; Kiyohito Murai; Nobuyuki Tamaki; Masaki Miyazaki; Kazuko Miyazaki; William J Romanow; Tomokatsu Ikawa; Daisuke Kitamura; Itaru Yanagihara; Nagahiro Minato; Cornelis Murre; Yasutoshi AgataJournal of immunology (Baltimore, Md. : 1950), 01 Jun. 2012
- The opposing roles of the transcription factor E2A and its antagonist Id3 that orchestrate and enforce the naive fate of T cells.Masaki Miyazaki; Richard R Rivera; Kazuko Miyazaki; Yin C Lin; Yasutoshi Agata; Cornelis MurreNature immunology, 21 Aug. 2011
- Polycomb group gene Bmi1 plays a role in the growth of thymic epithelial cells.Yun Guo; Masaki Miyazaki; Manami Itoi; Rumi Satoh; Atsushi Iwama; Takashi Amagai; Hiroshi Kawamoto; Masamoto KannoEuropean journal of immunology, Apr. 2011
- The role of the basic helix-loop-helix transcription factor Dec1 in the regulatory T cells.Kazuko Miyazaki; Masaki Miyazaki; Yun Guo; Norimasa Yamasaki; Masamoto Kanno; Zen-ichiro Honda; Hideaki Oda; Hiroshi Kawamoto; Hiroaki HondaJournal of immunology (Baltimore, Md. : 1950), 15 Dec. 2010
- Haploinsufficiency and acquired loss of Bcl11b and H2AX induces blast crisis of chronic myelogenous leukemia in a transgenic mouse model.Akiko Nagamachi; Norimasa Yamasaki; Kazuko Miyazaki; Hideaki Oda; Masaki Miyazaki; Zen-Ichiro Honda; Ryo Kominami; Toshiya Inaba; Hiroaki HondaCancer science, Jul. 2009
- Enhanced expression of p210BCR/ABL and aberrant expression of Zfp423/ZNF423 induce blast crisis of chronic myelogenous leukemia.Kazuko Miyazaki; Norimasa Yamasaki; Hideaki Oda; Takeshi Kuwata; Yohei Kanno; Masaki Miyazaki; Yukiko Komeno; Jiro Kitaura; Zen-ichiro Honda; Søren Warming; Nancy A Jenkins; Neal G Copeland; Toshio Kitamura; Takuro Nakamura; Hiroaki HondaBlood, 07 May 2009
- Thymocyte proliferation induced by pre-T cell receptor signaling is maintained through polycomb gene product Bmi-1-mediated Cdkn2a repression.Masaki Miyazaki; Kazuko Miyazaki; Manami Itoi; Yuko Katoh; Yun Guo; Rieko Kanno; Yuko Katoh-Fukui; Hiroaki Honda; Takashi Amagai; Maarten van Lohuizen; Hiroshi Kawamoto; Masamoto KannoImmunity, Feb. 2008
- Polycomb group gene mel-18 regulates early T progenitor expansion by maintaining the expression of Hes-1, a target of the Notch pathway.Masaki Miyazaki; Hiroshi Kawamoto; Yuko Kato; Manami Itoi; Kazuko Miyazaki; Kyoko Masuda; Satoshi Tashiro; Hiroto Ishihara; Kazuhiko Igarashi; Takashi Amagai; Rieko Kanno; Masamoto KannoJournal of immunology (Baltimore, Md. : 1950), 01 Mar. 2005
- TCDD treatment eliminates the long-term reconstitution activity of hematopoietic stem cells.Ruriko Sakai; Teruyuki Kajiume; Hiroko Inoue; Rieko Kanno; Masaki Miyazaki; Yuichi Ninomiya; Masamoto KannoToxicological sciences : an official journal of the Society of Toxicology, Mar. 2003
- Dimerization of the Polycomb-group protein Mel-18 is regulated by PKC phosphorylation.Seiji Fujisaki; Yuichi Ninomiya; Hiroto Ishihara; Masaki Miyazaki; Rieko Kanno; Toshimasa Asahara; Masamoto KannoBiochemical and biophysical research communications, 03 Jan. 2003
- Systemic fusariosis after a preparative regimen including thiotepa, VP-16 and busulfan used for blood stem cell transplantation in Hodgkin's disease.M Miyazaki; S Miyakoshi; M Kami; M Mori; Y Kishi; H Inagawa; U Machida; T Matsumura; S Kawagoe; J Ueyama; S Morinaga; H Matsushita; Y MutoLeukemia & lymphoma, Jan. 2001
Misc.
- The opposing roles of the transcription factor E2A and its antagonist Id3 that orchestrate and enforce the naive fate of T cells (vol 12, pg 992, 2011)Masaki Miyazaki; Richard R. Rivera; Kazuko Miyazaki; Yin C. Lin; Yasutoshi Agata; Cornelis MurreNATURE IMMUNOLOGY, Apr. 2013
- Transcriptional regulation by the E-Id protein axis controls T cell development and activation宮崎 正輝臨床免疫・アレルギー科 = Clinical immunology & allergology, Jul. 2016
- Transcriptional regulation during T cell differentiation and activation宮崎 正輝; 河本 宏臨床免疫・アレルギー科 = Clinical immunology & allergology, May 2016
- Haploinsufficiency and Deficiency of a 7q Gene Titan (Samd9L) Predispose Leukemia Development in Cooperation with Deregulated Expression of a Transcription Factor, Evil, or a Histone Demethylase, Fbxl10Akiko Nagamachi; Hiroya Asou; Hirotaka Matsui; Yuko Ozaki; Daisuke Aki; Kazuko Miyazaki; Norimasa Yamasaki; Masaki Miyazaki; Linda Wolff; Richard Koller; Hideaki Oda; Toshiya Inaba; Hiroaki HondaBLOOD, Nov. 2008
External funds: Kakenhi
- The Regulome controls adaptive lymphocyte development and DNA recombinase Rag1/Rag2 expressionGrant-in-Aid for Scientific Research (B)Basic Section 49070:Immunology-relatedKyoto UniversityMasaki MiyazakiFrom 01 Apr. 2019, To 31 Mar. 2022, Project Closed獲得免疫;Rag1 Rag2;T, B細胞;遺伝子再構成;エンハンサー;ゲノム構造;転写因子;E2A;adaptive lymphocyte;T cell and B cell;Rag1 and Rag2 expression;enhancer regulation;super-enhancer formation;V(D)J DNA recombination;獲得免疫リンパ球;Rag遺伝子;３次元ゲノム構造変換;転写因子E2A;３次元ゲノム構造;獲得免疫リンパ球分化;Rag1/Rag2遺伝子発現制御;3Dゲノム構造制御;T細胞分化;B細胞分化;Rag1/Rag2遺伝子;Regulame;リンパ球分化;エンハンサー調節;3Dゲノム
- The transcriptional regulation by E-Id protein axis upon T cell activation and its cellular metabolismGrant-in-Aid for Scientific Research (B)Kyoto UniversityMasaki MiyazakiFrom 01 Apr. 2016, To 31 Mar. 2019, Project ClosedT細胞;分化・活性化;転写因子;E2A, Id2, Id3;転写制御;E2A;Id2, Id3;T細胞分化と活性化;T細胞分化;自然リンパ球;E2A, Id2;リンパ腫;T細胞の分化・活性化;分化と活性化
- ポリコーム遺伝子bmi-1による幼若リンパ球の増殖と細胞死のバランス調節機構Grant-in-Aid for Young Scientists (B)Hiroshima University宮崎 正輝From 01 Apr. 2008, To 31 Mar. 2010, Project ClosedT細胞分化;エピジェネティック制御;ポリコーム遺伝子
- Elucidation of molecular mechanisms of maternal immune toleranceGrant-in-Aid for Challenging Research (Exploratory)Medium-sized Section 49:Pathology, infection/immunology, and related fieldsKyoto UniversityMasaki MiyazakiFrom 30 Jun. 2022, To 31 Mar. 2024, Project Closedリンパ球分化;免疫寛容;B細胞分化;授乳期;遺伝子発現制御;妊娠・授乳期における免疫細胞分化;T, B細胞分化;免疫反応;T細胞分化;妊娠;授乳;胸腺;骨髄;免疫応答
- Single cell multiome analyis unveils the regulatory mechanisms of T versus ILC lineage commitmentsGrant-in-Aid for Scientific Research (B)Basic Section 49070:Immunology-relatedKyoto University宮崎 正輝From 01 Apr. 2023, To 31 Mar. 2026, GrantedT細胞分化;転写制御;シングルセルmultiome解析;T細胞系列決定;自然リンパ球分化
- Functional analysis of Gene Desert as an enhancer reservoir in the establishment of cell lineage commitment and its diversityFund for the Promotion of Joint International Research (International Collaborative Research)Medium-sized Section 49:Pathology, infection/immunology, and related fieldsKyoto University宮崎 正輝From 08 Sep. 2023, To 31 Mar. 2028, Grantedエンハンサー制御;gene desert;細胞種特異的な遺伝子発現;クロマチン構造制御;転写因子;エンハンサー;Gene Desert;細胞種特異的;遺伝子発現;ゲノム構造制御
- Single cell multiome analyis unveils the regulatory mechanisms of T versus ILC lineage commitmentsGrant-in-Aid for Scientific Research (B)Basic Section 49070:Immunology-relatedKyoto University宮崎 正輝From 01 Apr. 2023, To 31 Mar. 2026, GrantedT細胞分化;自然リンパ球;転写制御;シングルセル解析;エンハンサー調節;転写因子;Notchシグナル;シングルセルmultiome解析;T細胞系列決定;自然リンパ球分化
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Last Updated :2025/06/20
Education
Teaching subject(s)
- From 01 Apr. 2025, To 31 Mar. 2026Immunology I8014, Fall, Faculty of Medicine, 2
- From 01 Apr. 2024, To 31 Mar. 2025Immunology I8014, Fall, Faculty of Medicine, 2
- From Apr. 2019, To Mar. 2020ILAS SeminarSpring, 全学共通科目
