Basic Information

Faculty

• 医学部

Professional Memberships

• THE JAPAN NEUROSCIENCE SOCIETY
• THE JAPANESE SOCIETY OF NEUROPSYCHOPHARMACOLOGY
• THE PHARMACEUTICAL SOCIETY OF JAPAN
• THE JAPANESE PHARMACOLOGICAL SOCIETY

Academic Degree

• 博士（薬学）(京都大学)

Research History

• From Apr. 2021, To Jul. 2021

  Graduate School of Medicine, Kyoto University, Pharmacology, 特定助教
• From Apr. 2018, To Mar. 2021

  Kyoto Prefectural University of Medicine, Pharmacology, Assistant Professor
• From Aug. 2021, To Present

  Graduate School of Medicine, Kyoto University, Pharmacology, 助教

ID,URL

• J-Global ID

  201801013893000855

researchmap URL

• https://researchmap.jp/nozomiasaoka

Research

Research Interests

• 意思決定
• 強迫性障害
• 行動薬理学
• 電気生理学
• 神経薬理学

Research Areas

• Life sciences, Neuropathology
• Life sciences, Neuroscience - general
• Life sciences, Pharmacology

Papers

• Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment.

  Hideo Hagihara; Hirotaka Shoji; Satoko Hattori; Giovanni Sala; Yoshihiro Takamiya; Mika Tanaka; Masafumi Ihara; Mihiro Shibutani; Izuho Hatada; Kei Hori; Mikio Hoshino; Akito Nakao; Yasuo Mori; Shigeo Okabe; Masayuki Matsushita; Anja Urbach; Yuta Katayama; Akinobu Matsumoto; Keiichi I Nakayama; Shota Katori; Takuya Sato; Takuji Iwasato; Haruko Nakamura; Yoshio Goshima; Matthieu Raveau; Tetsuya Tatsukawa; Kazuhiro Yamakawa; Noriko Takahashi; Haruo Kasai; Johji Inazawa; Ikuo Nobuhisa; Tetsushi Kagawa; Tetsuya Taga; Mohamed Darwish; Hirofumi Nishizono; Keizo Takao; Kiran Sapkota; Kazutoshi Nakazawa; Tsuyoshi Takagi; Haruki Fujisawa; Yoshihisa Sugimura; Kyosuke Yamanishi; Lakshmi Rajagopal; Nanette Deneen Hannah; Herbert Y Meltzer; Tohru Yamamoto; Shuji Wakatsuki; Toshiyuki Araki; Katsuhiko Tabuchi; Tadahiro Numakawa; Hiroshi Kunugi; Freesia L Huang; Atsuko Hayata-Takano; Hitoshi Hashimoto; Kota Tamada; Toru Takumi; Takaoki Kasahara; Tadafumi Kato; Isabella A Graef; Gerald R Crabtree; Nozomi Asaoka; Hikari Hatakama; Shuji Kaneko; Takao Kohno; Mitsuharu Hattori; Yoshio Hoshiba; Ryuhei Miyake; Kisho Obi-Nagata; Akiko Hayashi-Takagi; Léa J Becker; Ipek Yalcin; Yoko Hagino; Hiroko Kotajima-Murakami; Yuki Moriya; Kazutaka Ikeda; Hyopil Kim; Bong-Kiun Kaang; Hikari Otabi; Yuta Yoshida; Atsushi Toyoda; Noboru H Komiyama; Seth G N Grant; Michiru Ida-Eto; Masaaki Narita; Ken-Ichi Matsumoto; Emiko Okuda-Ashitaka; Iori Ohmori; Tadayuki Shimada; Kanato Yamagata; Hiroshi Ageta; Kunihiro Tsuchida; Kaoru Inokuchi; Takayuki Sassa; Akio Kihara; Motoaki Fukasawa; Nobuteru Usuda; Tayo Katano; Teruyuki Tanaka; Yoshihiro Yoshihara; Michihiro Igarashi; Takashi Hayashi; Kaori Ishikawa; Satoshi Yamamoto; Naoya Nishimura; Kazuto Nakada; Shinji Hirotsune; Kiyoshi Egawa; Kazuma Higashisaka; Yasuo Tsutsumi; Shoko Nishihara; Noriyuki Sugo; Takeshi Yagi; Naoto Ueno; Tomomi Yamamoto; Yoshihiro Kubo; Rie Ohashi; Nobuyuki Shiina; Kimiko Shimizu; Sayaka Higo-Yamamoto; Katsutaka Oishi; Hisashi Mori; Tamio Furuse; Masaru Tamura; Hisashi Shirakawa; Daiki X Sato; Yukiko U Inoue; Takayoshi Inoue; Yuriko Komine; Tetsuo Yamamori; Kenji Sakimura; Tsuyoshi Miyakawa

  eLife, 26 Mar. 2024, Peer-reviewed

  
• Infection-induced extracellular vesicles evoke neuronal transcriptional and epigenetic changes.

  Ellen Tedford; Norhidayah Binti Badya; Conor Laing; Nozomi Asaoka; Shuji Kaneko; Beatrice Maria Filippi; Glenn Alan McConkey

  Scientific reports, 27 Apr. 2023, Peer-reviewed

  
• Amelioration of obsessive-compulsive disorder by intracellular acidification of cortical neurons with a proton pump inhibitor.

  Hikari Hatakama; Nozomi Asaoka; Kazuki Nagayasu; Hisashi Shirakawa; Shuji Kaneko

  Translational psychiatry, 16 Jan. 2024, Peer-reviewed, Corresponding author

  
• Enhancement of adenosine A2A signaling improves dopamine D2 receptor antagonist-induced dyskinesia via β-arrestin signaling.

  Koki Nagaoka; Nozomi Asaoka; Kazuki Nagayasu; Hisashi Shirakawa; Shuji Kaneko

  Frontiers in neuroscience, 2022, Peer-reviewed

  
• Bortezomib is an effective enhancer for chemical probe-dependent superoxide detection.

  Misaki Matsumoto; Hikari Sawada; Kazumi Iwata; Masakazu Ibi; Nozomi Asaoka; Masato Katsuyama; Kaori Shintani-Ishida; Hiroshi Ikegaya; Shigehiko Takegami; Atsushi Umemura; Chihiro Yabe-Nishimura

  Frontiers in medicine, 2022, Peer-reviewed

  
• A selective serotonin reuptake inhibitor ameliorates obsessive–compulsive disorder-like perseverative behavior by attenuating 5-HT2C receptor signaling in the orbitofrontal cortex

  Hikari Hatakama; Nozomi Asaoka; Kazuki Nagayasu; Hisashi Shirakawa; Shuji Kaneko

  Neuropharmacology, Mar. 2022, Peer-reviewed, Lead author, Corresponding author

  
• NOX1/NADPH oxidase is involved in the LPS-induced exacerbation of collagen-induced arthritis

  Misaki Matsumoto; Junjie Liu; Kazumi Iwata; Masakazu Ibi; Nozomi Asaoka; Xueqing Zhang; Masato Katsuyama; Masaya Matsuda; Takeshi Nabe; Katrin Schröder; Chihiro Yabe-Nishimura

  Journal of Pharmacological Sciences, Jun. 2021, Peer-reviewed

  
• Striatal TRPV1 activation by acetaminophen ameliorates dopamine D2 receptor antagonists-induced orofacial dyskinesia

  Koki Nagaoka; Takuya Nagashima; Nozomi Asaoka; Hiroki Yamamoto; Chihiro Toda; Gen Kayanuma; Soni Siswanto; Yasuhiro Funahashi; Keisuke Kuroda; Kozo Kaibuchi; Yasuo Mori; Kazuki Nagayasu; Hisashi Shirakawa; Shuji Kaneko

  JCI Insight, 15 Apr. 2021, Peer-reviewed

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• NOX1/NADPH Oxidase Promotes Synaptic Facilitation Induced by Repeated D2 Receptor Stimulation: Involvement in Behavioral Repetition

  Nozomi Asaoka; Masakazu Ibi; Hikari Hatakama; Koki Nagaoka; Kazumi Iwata; Misaki Matsumoto; Masato Katsuyama; Shuji Kaneko; Chihiro Yabe-Nishimura

  The Journal of Neuroscience, 24 Mar. 2021, Peer-reviewed, Lead author, Corresponding author

  
• Clioquinol inhibits dopamine-β-hydroxylase secretion and noradrenaline synthesis by affecting the redox status of ATOX1 and copper transport in human neuroblastoma SH-SY5Y cells.

  Masato Katsuyama; En Kimura; Masakazu Ibi; Kazumi Iwata; Misaki Matsumoto; Nozomi Asaoka; Chihiro Yabe-Nishimura

  Archives of toxicology, Jan. 2021, Peer-reviewed

  
• NOX1/NADPH oxidase affects the development of autism-like behaviors in a maternal immune activation model

  Xueqing Zhang; Masakazu Ibi; Ryu Haga; Kazumi Iwata; Misaki Matsumoto; Nozomi Asaoka; Junjie Liu; Masato Katsuyama; Chihiro Yabe-Nishimura

  Biochemical and Biophysical Research Communications, Jan. 2021, Peer-reviewed

  
• NOX1/NADPH oxidase in bone marrow-derived cells modulates intestinal barrier function

  Junjie Liu; Kazumi Iwata; Kai Zhu; Misaki Matsumoto; Kenjiro Matsumoto; Nozomi Asaoka; Xueqing Zhang; Masakazu Ibi; Masato Katsuyama; Masato Tsutsui; Shinichi Kato; Chihiro Yabe-Nishimura

  Free Radical Biology and Medicine, 01 Feb. 2020, Peer-reviewed

  
• Manipulation of dorsal raphe serotonergic neurons modulates active coping to inescapable stress and anxiety-related behaviors in mice and rats.

  Naoya Nishitani; Kazuki Nagayasu; Nozomi Asaoka; Mayumi Yamashiro; Chihiro Andoh; Yuma Nagai; Haruko Kinoshita; Hiroyuki Kawai; Norihiro Shibui; Beihui Liu; James Hewinson; Hisashi Shirakawa; Takayuki Nakagawa; Hitoshi Hashimoto; Sergey Kasparov; Shuji Kaneko

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, Mar. 2019, Peer-reviewed, Lead author

  
• NOX1/NADPH oxidase regulates the expression of multidrug resistance-associated protein 1 and maintains intracellular glutathione levels

  Xiaopeng Wen; Kazumi Iwata; Keiko Ikuta; Xueqing Zhang; Kai Zhu; Masakazu Ibi; Misaki Matsumoto; Nozomi Asaoka; Junjie Liu; Masato Katsuyama; Chihiro Yabe-Nishimura

  FEBS Journal, Feb. 2019, Peer-reviewed

  
• An Adenosine A_2A Receptor Antagonist Improves Multiple Symptoms of Repeated Quinpirole-Induced Psychosis.

  Asaoka N; Nishitani N; Kinoshita H; Nagai Y; Hatakama H; Nagayasu K; Shirakawa H; Nakagawa T; Kaneko S

  eNeuro, Jan. 2019, Peer-reviewed, Lead author

  
• Neurotropin inhibits neuronal activity through potentiation of sustained Kv currents in primary cultured DRG neurons.

  Hiroyuki Kawai; Nozomi Asaoka; Takahito Miyake; Kazuki Nagayasu; Takayuki Nakagawa; Hisashi Shirakawa; Shuji Kaneko

  Journal of pharmacological sciences, Jul. 2018, Peer-reviewed

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• Ketamine-Induced Prefrontal Serotonin Release Is Mediated by Cholinergic Neurons in the Pedunculopontine Tegmental Nucleus.

  Haruko Kinoshita; Naoya Nishitani; Yuma Nagai; Chihiro Andoh; Nozomi Asaoka; Hiroyuki Kawai; Norihiro Shibui; Kazuki Nagayasu; Hisashi Shirakawa; Takayuki Nakagawa; Shuji Kaneko

  The international journal of neuropsychopharmacology, 01 Mar. 2018, Peer-reviewed

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• Chronic antidepressant potentiates spontaneous activity of dorsal raphe serotonergic neurons by decreasing GABA(B) receptor-mediated inhibition of L-type calcium channels

  Nozomi Asaoka; Naoya Nishitani; Haruko Kinoshita; Hiroyuki Kawai; Norihiro Shibui; Kazuki Nagayasu; Hisashi Shirakawa; Takayuki Nakagawa; Shuji Kaneko

  SCIENTIFIC REPORTS, Oct. 2017, Peer-reviewed, Lead author

  
• A new designer drug 5F-ADB activates midbrain dopaminergic neurons but not serotonergic neurons

  Nozomi Asaoka; Hiroyuki Kawai; Naoya Nishitani; Haruko Kinoshita; Norihiro Shibui; Kazuki Nagayasu; Hisashi Shirakawa; Shuji Kaneko

  JOURNAL OF TOXICOLOGICAL SCIENCES, Dec. 2016, Peer-reviewed, Lead author

  
• Olanzapine augments the effect of selective serotonin reuptake inhibitors by suppressing GABAergic inhibition via antagonism of 5-HT6 receptors in the dorsal raphe nucleus

  Nozomi Asaoka; Kazuki Nagayasu; Naoya Nishitani; Mayumi Yamashiro; Hisashi Shirakawa; Takayuki Nakagawa; Shuji Kaneko

  NEUROPHARMACOLOGY, Aug. 2015, Peer-reviewed, Lead author

  
• Inhibition of histone deacetylases enhances the function of serotoninergic neurons in organotypic raphe slice cultures

  Nozomi Asaoka; Kazuki Nagayasu; Naoya Nishitani; Mayumi Yamashiro; Hisashi Shirakawa; Takayuki Nakagawa; Shuji Kaneko

  NEUROSCIENCE LETTERS, Apr. 2015, Peer-reviewed, Lead author

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• Raphe AMPA receptors and nicotinic acetylcholine receptors mediate ketamine-induced serotonin release in the rat prefrontal cortex

  Naoya Nishitani; Kazuki Nagayasu; Nozomi Asaoka; Mayumi Yamashiro; Hisashi Shirakawa; Takayuki Nakagawa; Shuji Kaneko

  INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, Aug. 2014, Peer-reviewed

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• Chronic effects of antidepressants on serotonin release in rat raphe slice cultures: high potency of milnacipran in the augmentation of serotonin release

  Kazuki Nagayasu; Maiko Kitaichi; Naoya Nishitani; Nozomi Asaoka; Hisashi Shirakawa; Takayuki Nakagawa; Shuji Kaneko

  INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, Nov. 2013, Peer-reviewed

  

Presentations

• Big data-driven insights into mechanisms and potential treatment for obsessive-compulsive disorder

  Nozomi Asaoka

  6th Japan-UK Neuroscience Symposium, 26 Jan. 2025, Invited

  
• Distinct roles of synaptic plasticity in the prefrontal cortex in habit formation and execution

  Nozomi Asaoka; Yasunori Hayashi

  NEURO2024, Jul. 2024, Invited

  
• Region-specific plastic changes in the prefrontal cortex drive compulsive task performance

  Nozomi Asaoka; Yasunori Hayashi

  35th World Congress Collegium Internationale Neuro-Psychopharmacologicum, May 2024

  
• Region- and circuit-specific synaptic plasticity in the prefrontal cortex determine the individuality in habit execution

  Nozomi Asaoka, Yasunori Hayashi

  第97回日本薬理学会年会・第44回日本臨床薬理学会学術総会, Dec. 2023

  
• Region-specific cortical plasticity during habit formation determines individuality

  Nozomi Asaoka, Yasunori Hayashi

  生理研研究会記憶研究会2023, Sep. 2023

  
• Region-specific cortical plasticity during habit formation determines individuality in habit strength

  Nozomi Asaoka, Yasunori Hayashi

  第46回日本神経科学大会, Aug. 2023

  
• Region-specific plastic changes in the prefrontal cortex drive compulsive task performance

  Nozomi Asaoka, Yasunori Hayashi

  第96回日本薬理学会年会/第43回日本臨床薬理学会学術総会, Dec. 2022

  
• Region- and proficiency-specific synaptic potentiation in the prefrontal cortex during learning of normal and workaholic-like operant behavior

  Nozomi Asaoka, Yasunori Hayashi

  Neuro2022, Jul. 2022

  
• Region- and proficiency-specific synaptic potentiation in the prefrontal cortex during learning of normal and compulsive operant behavior

  Nozomi Asaoka, Yasunori Hayashi

  第2回国際シンポジウム マルチスケール脳/MCCS-Asia, Jun. 2022

  
• NOX1/NADPH oxidase regulates compulsive-like repetitive behaviors through promoting D2 receptor-mediated synaptic facilitation in the striatum

  浅岡 希美

  第94回日本薬理学会年会, 08 Mar. 2021

  
• An adenosine A2A receptor antagonist, istradefylline, improves multiple symptoms reflecting obsessive-compulsive disorder in mice

  Asaoka Nozomi

  The 6th Asian College of Neuropsychopharmacology, 13 Nov. 2019

  
• Developing novel treatment strategies for OCD by utilizing rodent models: a therapeutic potential of adenosine A2A receptor antagonism

  Nozomi Asaoka; Chihiro Yabe-Nishimura; Shuji Kaneko

  The 6th Asian College of Neuropsychopharmacology, 11 Nov. 2019, Invited

  
• Blockade of adenosine A2A receptor improves repeated dopamine D2 receptor stimulation-induced multiple abnormalities reflecting obsessive-compulsive disorder

  Asaoka Nozomi

  Neuro2019, 27 Jul. 2019

  
• An adenosine A2A receptor antagonist improves multiple symptoms reflecting obsessive-compulsive disorder

  Asaoka Nozomi

  第92回日本薬理学会年会, 16 Mar. 2019

  
• An adenosine A2A receptor antagonist, istradefylline, improves multiple symptoms reflecting obsessive-compulsive disorder in a novel murine model

  Asaoka Nozomi

  18th World Congress of Basic and Clinical Pharmacology, 05 Jul. 2018

  
• A novel strategy for developing treatment of obsessive-compulsive disorder

  Asaoka Nozomi

  日本薬学会第138年会, 26 Mar. 2018

  
• 新規強迫性障害モデルの作成：妥当性評価から治療ターゲット探索まで

  浅岡 希美

  第 132 回日本薬理学会近畿部会, 24 Nov. 2017

  
• Chronic treatment with a selective serotonin reuptake inhibitor increases spontaneous activity of dorsal raphe nucleus serotonergic neurons through activating L-type voltage dependent Ca2+ channels

  Asaoka Nozomi

  Neuroscience 2017, 11 Nov. 2017

  
• Chronic antidepressant treatment increases pacemaker activity of dorsal raphe serotonergic neurons

  Asaoka Nozomi

  第90回日本薬理学会年会, 15 Mar. 2017

  
• ドパミン・セロトニン神経活動における危険ドラッグ5F-ADBの影響

  浅岡 希美

  第130回日本薬理学会近畿部会, 19 Nov. 2016

  
• Involvement of 5-HT6 receptor in local feedback inhibition of the dorsal raphe serotonergic neurons

  Asaoka Nozomi

  第92 回日本生理学会大会・第120 回日本解剖学会総会・全国学術集会, 21 Mar. 2015

  
• ヒストン脱アセチル化酵素阻害薬の持続処置が縫線核セロトニン神経に与える影響

  浅岡 希美

  第44 回日本神経精神薬理学会・第24 回日本臨床精神神経薬理学会 合同年会, 20 Nov. 2014

  
• オランザピンの縫線核セロ トニン神経に対する作用と SSRI 作用増強機構

  浅岡 希美

  次世代を担う創薬・医療薬理シンポジウム 2014, 30 Aug. 2014

  
• 縫線核5-HT神経におけるオランザピンの作用とSSRI作用増強機構の解析

  浅岡 希美

  第125 回日本薬理学会近畿部会, 20 Jun. 2014

  
• 縫線核含有切片培養系を用いたヒストン脱アセチル化酵素阻害薬によるセロトニン遊離増強機序の解析

  浅岡 希美

  第 63 回日本薬学会近畿支部大会, 12 Oct. 2013

  
• NOX1/NADPH oxidaseはドパミンD2受容体を介した 線条体のシナプス増強を促進することで強迫様行動の誘発に関与する

  浅岡 希美; 金子 周司; 矢部 千尋

  第71回 日本薬学会関西支部総会・大会, 09 Oct. 2021

  
• NOX1/NADPH oxidase regulates compulsive-like repetitive behaviors through promoting D2 receptor-mediated synaptic facilitation in the striatum

  Nozomi Asaoka; Shuji Kaneko; Chihiro Yabe-Nishimura

  第44回日本神経科学大会 CJK第1回国際会議, 28 Jul. 2021

  
• NOX1/NADPH oxidase regulates compulsive-like repetitive behaviors through promoting D2 receptor-mediated synaptic facilitation in the striatum

  Nozomi Asaoka; Shuji Kaneko; Chihiro Yabe-Nishimura

  第43回 日本生物学的精神医学会 第51回 日本神経精神薬理学会, 14 Jul. 2021

  

External funds: Kakenhi

• Pathophysiological mechanisms and therapeutic targets for abnormal habit formation-related obsessive-compulsive symptoms

  Grant-in-Aid for Early-Career Scientists

  Basic Section 47040:Pharmacology-related

  Kyoto University;Kyoto Prefectural University of Medicine

  Nozomi Asaoka

  From 01 Apr. 2020, To 31 Mar. 2022, Project Closed

  強迫性障害;線条体;ドパミンD2受容体;活性酸素産生酵素;習慣;D2受容体

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K16009/
• Elucidation of role of NOX1/NADPH oxidase in the development of neurodevelopment disorders.

  Grant-in-Aid for Scientific Research (C)

  Basic Section 47040:Pharmacology-related

  Kinjo Gakuin University;Kyoto Prefectural University of Medicine

  Masakazu Ibi

  From 01 Apr. 2020, To 31 Mar. 2024, Project Closed

  発達障害;活性酸素種;ASD;NADPHオキシダーゼ;精神疾患;NOX1;自閉症様行動;母体免疫活性化;小脳;プルキンエ細胞;神経発達障害

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K07087/
• Drug target finding based on the analysis of real world data

  Grant-in-Aid for Scientific Research (A)

  Medium-sized Section 47:Pharmaceutical sciences and related fields

  Kyoto University

  Shuji Kaneko

  From 01 Apr. 2020, To 31 Mar. 2023, Project Closed

  リアルワールドデータ;レセプト;ビッグデータ;電子カルテ;薬理学;創薬;臨床検査値;臨床予測性;有害事象;ドラッグリポジショニング;AI創薬

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H00491/
• Pathophysiological roles of ventral striatal ROS signaling in obsessive compulsive disorder

  Grant-in-Aid for Research Activity Start-up

  0802:Biomedical structure and function and related fields

  Kyoto Prefectural University of Medicine

  Nozomi Asaoka

  From 24 Aug. 2018, To 31 Mar. 2020, Project Closed

  強迫性障害;線条体;眼窩前頭皮質;活性酸素

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K21244/
• タスク経験の記憶固定化に着目した仕事中毒の神経基盤の解析

  Grant-in-Aid for Early-Career Scientists

  Basic Section 47040:Pharmacology-related

  Kyoto University

  浅岡 希美

  From 01 Apr. 2022, To 31 Mar. 2025, Granted

  習慣;強迫;前頭皮質;強迫性;仕事中毒;強迫的意思決定;記憶固定化

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K15291/
• Neural and Therapeutic Mechanisms Underlying the Execution of Abnormal Habits

  Grant-in-Aid for Scientific Research (B)

  Basic Section 51030:Pathophysiologic neuroscience-related

  Kyoto University

  浅岡 希美

  From 01 Apr. 2025, To 31 Mar. 2029, Granted

  習慣;強迫;前頭皮質;線条体

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25K02556/