Basic Information

Faculty

• Faculty of Medicine

Email Address

• Email Address

  ohara.hiroaki.3jkyoto-u.ac.jp

Academic Degree

• 23 Jan. 2024

  京都大学博士（医学）

Academic Resume (Graduate Schools)

• 京都大学, 大学院医学研究科博士課程医学専攻, 修了
• 京都大学, 大学院医学研究科博士課程医学専攻, 研究指導認定退学

Academic Resume (Undergraduate School/Majors)

• 奈良県立医科大学, 医学部医学科, 卒業
• 奈良県立医科大学, 医学部医学科, 卒業

ID,URL

• J-Global ID

  202201011099158924

• Researcher number

  20964018

researchmap URL

• https://researchmap.jp/hiroakiohara

Research

Papers

• イントロン変異を原因とする筋ジストロフィーの治療

  大原 寛明; 細川 元靖; 粟屋 智就; 高橋 良輔; 小笠原 真志; 野口 悟; 後藤 雄一; 西野 一三; 萩原 正敏

  日本筋学会学術集会プログラム・抄録集, Dec. 2020

  
• Utilization of Induced Pluripotent Stem Cell-Derived Neurons to Investigate the Splice-Modification Efficacy of Splice-Switching Drug Candidates

  Yukiko Ueta; Hiroaki Ohara; Tomonari Awaya; Masatoshi Hagiwara

  Methods in Molecular Biology, 01 Oct. 2025

  
• Substitutions of nucleotides at the 3' ends of COL6A1/2/3 exons induce exon skipping associated with collagen VI-related muscular dystrophies and therapeutic strategies

  Seung-Ah Lee; Megumu Ogawa; Yoshihiko Saito; Rui Shimazaki; Tomonari Awaya; Motoyasu Hosokawa; Ryo Kurosawa; Hiroaki Ohara; Akihide Takeuchi; Shinichiro Hayashi; Yu-ichi Goto; Masatoshi Hagiwara; Ichizo Nishino; Satoru Noguchi

  Genetics in Medicine, Apr. 2025

  
• Profiling of pathogenic variants in Japanese patients with sarcoglycanopathy

  Rui Shimazaki; Yoshihiko Saito; Tomonari Awaya; Narihiro Minami; Ryo Kurosawa; Motoyasu Hosokawa; Hiroaki Ohara; Shinichiro Hayashi; Akihide Takeuchi; Masatoshi Hagiwara; Yukiko K. Hayashi; Satoru Noguchi; Ichizo Nishino

  Orphanet Journal of Rare Diseases, 04 Jan. 2025

  
• Branchpoints as potential targets of exon-skipping therapies for genetic disorders.

  Hiroaki Ohara; Motoyasu Hosokawa; Tomonari Awaya; Atsuko Hagiwara; Ryo Kurosawa; Yukiya Sako; Megumu Ogawa; Masashi Ogasawara; Satoru Noguchi; Yuichi Goto; Ryosuke Takahashi; Ichizo Nishino; Masatoshi Hagiwara

  Molecular therapy. Nucleic acids, 12 Sep. 2023

  Access this paper :

  
• Antagonist of sphingosine 1-phosphate receptor 3 reduces cold injury of rat donor hearts for transplantation

  Eisho Kanemitsu; Xiangdong Zhao; Keiko Iwaisako; Asuka Inoue; Akihide Takeuchi; Shintaro Yagi; Hidetoshi Masumoto; Hiroaki Ohara; Motoyasu Hosokawa; Tomonari Awaya; Junken Aoki; Etsuro Hatano; Shinji Uemoto; Masatoshi Hagiwara

  Translational Research, Nov. 2022

  
• Intracardiac Thrombus Following Rivaroxaban Treatment in a Patient with Atrial Fibrillation Associated with Rheumatic Heart Disease

  Hiroaki Ohara; Shiro Yamamoto; Keiko Nagano; Kazuo Hashikawa

  Journal of Stroke and Cerebrovascular Diseases, Nov. 2019

  

Books and Other Publications

• 指定難病ペディア

  水澤, 英洋; 五十嵐, 隆; 北川, 泰久; 高橋, 和久(内科学); 弓倉, 整, Contributor, 13 ハンチントン病 ［指定難病8］

  日本医師会,診断と治療社 (発売), Jul. 2019

  Find Kyoto University's collection of books :

  

Awards

• 12 Dec. 2021

  第7回日本筋学会学術集会 Student Award 最優秀賞
• 19 May 2021

  第62回日本神経学会学術大会 優秀演題賞
• 12 Dec. 2021

  第7回日本筋学会学術集会 Student Award 最優秀賞
• 19 May 2021

  第62回日本神経学会学術大会 優秀演題賞

External funds: Kakenhi

• Establishment of a new exon skipping method targeting branchpoints

  Grant-in-Aid for Research Activity Start-up

  0801:Pharmaceutical sciences and related fields

  Kyoto University;Japanese Red Cross Wakayama Medical Center

  Hiroaki Ohara

  From 31 Aug. 2022, To 31 Mar. 2025, Project Closed

  アンチセンス核酸;ブランチポイント;RNAスプライシング;スプライシング

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K20710/
• Establishment of novel gene therapy with antisense oligonucleotide targeting branchpoints

  Grant-in-Aid for Early-Career Scientists

  Basic Section 48030:Pharmacology-related

  Kyoto University

  大原 寛明

  From 01 Apr. 2025, To 31 Mar. 2028, Granted

  アンチセンス核酸;RNAスプライシング;ブランチポイント

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25K18711/