Basic Information

Faculty

• 医学部

Concurrent Affiliation

• Center for iPS Cell Research and Application (CiRA), 連携主任研究者
• Center for Educational Program Promotion in Graduate School, メディカルイノベーション卓越大学院, 教授

Academic Degree

• 博士（医学）(京都大学)

ID,URL

• J-Global ID

  201401017906071892

researchmap URL

• https://researchmap.jp/7000008794

Research

Research Topics, Overview of the research

• Research Topics

  生殖細胞の発生・増殖・分化・成熟機構とその再構成、エピゲノム再編成の分子機構、微量エピゲノム解析法の開発、幹細胞の増殖制御機構とその応用

Research Areas

• Life sciences, Developmental biology

Papers

• In Vitro Spermatogenesis

  Yukiko Ishikura; Mitinori Saitou

  Encyclopedia of Reproduction, 2018, Peer-reviewed

  
• Blimp1 and the emergence of the germ line during development in the mouse

  M Saitou; B Payer; D O'Carroll; Y Ohinata; MA Surani

  CELL CYCLE, Dec. 2005, Peer-reviewed

  
• Blimp1 is a critical determinant of the germ cell lineage in mice

  Y Ohinata; B Payer; D O'Carroll; K Ancelin; Y Ono; M Sano; SC Barton; T Obukhanych; M Nussenzweig; A Tarakhovsky; M Saitou; MA Surani

  NATURE, Jul. 2005, Peer-reviewed

  
• 始原生殖細胞におけるDNAの脱メチル化と2価ヒストン修飾を介した選択的なエピジェネティック遺伝子調節(Selective epigenetic gene regulation via DNA demethylation and bivalent histone modification in primordial germ cells)

  Mochizuki Kentaro; Tachibana Makoto; Saitou Mitinori; Tokitake Yuko; Matsui Yasuhisa

  日本発生生物学会・日本細胞生物学会合同大会要旨集, Apr. 2012

  
• Key mechanisms and in vitro reconstitution of fetal oocyte development in mammals

  Ken Mizuta; Mitinori Saitou

  Current Opinion in Genetics & Development, Oct. 2023, Peer-reviewed

  
• Non-viral generation of transgenic non-human primates via the piggyBac transposon system.

  Masataka Nakaya; Chizuru Iwatani; Setsuko Tsukiyama-Fujii; Ai Mieda; Shoko Tarumoto; Taro Tsujimura; Takuya Yamamoto; Takafumi Ichikawa; Tomonori Nakamura; Ichiro Terakado; Ikuo Kawamoto; Takahiro Nakagawa; Iori Itagaki; Mitinori Saitou; Hideaki Tsuchiya; Tomoyuki Tsukiyama

  Nature communications, 24 Mar. 2025

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• Resolution of the curse of dimensionality in single-cell RNA sequencing data analysis

  Yusuke Imoto; Tomonori Nakamura; Emerson G Escolar; Michio Yoshiwaki; Yoji Kojima; Yukihiro Yabuta; Yoshitaka Katou; Takuya Yamamoto; Yasuaki Hiraoka; Mitinori Saitou

  Life Science Alliance, Dec. 2022, Peer-reviewed

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• The balance between IFN-γ and ERK/MAPK signaling activities ensures lifelong maintenance of intestinal stem cells

  May Nakajima-Koyama; Mio Kabata; Joonseong Lee; Yuko Sogabe; Satoko Sakurai; Akira Hirota; Mizuki Kimura; Tomonori Nakamura; Yusuke Imoto; Kohei Kometani; Yoko Hamazaki; Yasuaki Hiraoka; Mitinori Saitou; Eisuke Nishida; Takuya Yamamoto

  Cell Reports, Feb. 2025

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• Hypoblast from human pluripotent stem cells regulates epiblast development.

  Takumi Okubo; Nicolas Rivron; Mio Kabata; Hideki Masaki; Keiko Kishimoto; Katsunori Semi; May Nakajima-Koyama; Haruko Kunitomi; Belinda Kaswandy; Hideyuki Sato; Hiromitsu Nakauchi; Knut Woltjen; Mitinori Saitou; Erika Sasaki; Takuya Yamamoto; Yasuhiro Takashima

  Nature, 05 Dec. 2023

  
• Ex vivo reconstitution of fetal oocyte development in humans and cynomolgus monkeys.

  Ken Mizuta; Yoshitaka Katou; Baku Nakakita; Aoi Kishine; Yoshiaki Nosaka; Saki Saito; Chizuru Iwatani; Hideaki Tsuchiya; Ikuo Kawamoto; Masataka Nakaya; Tomoyuki Tsukiyama; Masahiro Nagano; Yoji Kojima; Tomonori Nakamura; Yukihiro Yabuta; Akihito Horie; Masaki Mandai; Hiroshi Ohta; Mitinori Saitou

  The EMBO journal, 15 Sep. 2022, Peer-reviewed

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• Generation of transgenic cynomolgus monkeys that express green fluorescent protein throughout the whole body

  Yasunari Seita; Tomoyuki Tsukiyama; Chizuru Iwatani; Hideaki Tsuchiya; Jun Matsushita; Takuya Azami; Junko Okahara; Shinichiro Nakamura; Yoshitaka Hayashi; Seiji Hitoshi; Yasushi Itoh; Takeshi Imamura; Masaki Nishimura; Ikuo Tooyama; Hiroyuki Miyoshi; Mitinori Saitou; Kazumasa Ogasawara; Erika Sasaki; Masatsugu Ema

  Scientific Reports, Apr. 2016, Peer-reviewed

  
• Generation of functional oocytes from male mice in vitro.

  Kenta Murakami; Nobuhiko Hamazaki; Norio Hamada; Go Nagamatsu; Ikuhiro Okamoto; Hiroshi Ohta; Yoshiaki Nosaka; Yukiko Ishikura; Tomoya S Kitajima; Yuichiro Semba; Yuya Kunisaki; Fumio Arai; Koichi Akashi; Mitinori Saitou; Kiyoko Kato; Katsuhiko Hayashi

  Nature, 15 Mar. 2023, Peer-reviewed

  
• Establishment of macaque trophoblast stem cell lines derived from cynomolgus monkey blastocysts.

  Shoma Matsumoto; Christopher J Porter; Naomi Ogasawara; Chizuru Iwatani; Hideaki Tsuchiya; Yasunari Seita; Yu-Wei Chang; Ikuhiro Okamoto; Mitinori Saitou; Masatsugu Ema; Theodore J Perkins; William L Stanford; Satoshi Tanaka

  Scientific reports, 22 Apr. 2020, Peer-reviewed

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• DMRT1-mediated reprogramming drives development of cancer resembling human germ cell tumors with features of totipotency.

  Jumpei Taguchi; Hirofumi Shibata; Mio Kabata; Masaki Kato; Kei Fukuda; Akito Tanaka; Sho Ohta; Tomoyo Ukai; Kanae Mitsunaga; Yosuke Yamada; So I Nagaoka; Sho Yamazawa; Kotaro Ohnishi; Knut Woltjen; Tetsuo Ushiku; Manabu Ozawa; Mitinori Saitou; Yoichi Shinkai; Takuya Yamamoto; Yasuhiro Yamada

  Nature communications, 19 Aug. 2021

  
• In vitro reconstitution of epigenetic reprogramming in the human germ line

  Yusuke Murase; Ryuta Yokogawa; Yukihiro Yabuta; Masahiro Nagano; Yoshitaka Katou; Manami Mizuyama; Ayaka Kitamura; Pimpitcha Puangsricharoen; Chika Yamashiro; Bo Hu; Ken Mizuta; Taro Tsujimura; Takuya Yamamoto; Kosuke Ogata; Yasushi Ishihama; Mitinori Saitou

  Nature, 20 May 2024

  
• DPPA3 facilitates genome-wide DNA demethylation in mouse primordial germ cells

  Keisuke Toriyama; Wan Kin Au Yeung; Azusa Inoue; Kazuki Kurimoto; Yukihiro Yabuta; Mitinori Saitou; Toshinobu Nakamura; Toru Nakano; Hiroyuki Sasaki

  BMC Genomics, 05 Apr. 2024, Peer-reviewed

  
• Induction of fetal meiotic oocytes from embryonic stem cells in cynomolgus monkeys

  Sayuri Gyobu‐Motani; Yukihiro Yabuta; Ken Mizuta; Yoshitaka Katou; Ikuhiro Okamoto; Masanori Kawasaki; Ayaka Kitamura; Tomoyuki Tsukiyama; Chizuru Iwatani; Hideaki Tsuchiya; Taro Tsujimura; Takuya Yamamoto; Tomonori Nakamura; Mitinori Saitou

  The EMBO Journal, 16 Mar. 2023, Peer-reviewed

  
• Cohesin controls X chromosome structure remodeling and X-reactivation during mouse iPSC-reprogramming.

  Serena F Generoso; Maria Victoria Neguembor; Elliot A Hershberg; Ruslan I Sadreyev; Kazuki Kurimoto; Yukihiro Yabuta; Raffaele Ricci; Pauline Audergon; Moritz Bauer; Mitinori Saitou; Konrad Hochedlinger; Brian J Beliveau; Maria Pia Cosma; Jeannie T Lee; Bernhard Payer

  Proceedings of the National Academy of Sciences of the United States of America, 24 Jan. 2023

  
• Mesothelial fusion mediates chorioallantoic membrane formation.

  Hiroki Nagai; Yuki Tanoue; Tomonori Nakamura; Christopher J J Chan; Shigehito Yamada; Mitinori Saitou; Takaichi Fukuda; Guojun Sheng

  Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 05 Dec. 2022

  
• Optimized protocol to derive germline stem-cell-like cells from mouse pluripotent stem cells.

  Yukiko Ishikura; Hiroshi Ohta; Masahiro Nagano; Mitinori Saitou

  STAR protocols, 16 Sep. 2022

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• Nucleome programming is required for the foundation of totipotency in mammalian germline development

  Masahiro Nagano; Bo Hu; Shihori Yokobayashi; Akitoshi Yamamura; Fumiya Umemura; Mariel Coradin; Hiroshi Ohta; Yukihiro Yabuta; Yukiko Ishikura; Ikuhiro Okamoto; Hiroki Ikeda; Naofumi Kawahira; Yoshiaki Nosaka; Sakura Shimizu; Yoji Kojima; Ken Mizuta; Tomoko Kasahara; Yusuke Imoto; Killian Meehan; Roman Stocsits; Gordana Wutz; Yasuaki Hiraoka; Yasuhiro Murakawa; Takuya Yamamoto; Kikue Tachibana; Jan‐Michel Peters; Leonid A Mirny; Benjamin A Garcia; Jacek Majewski; Mitinori Saitou

  The EMBO Journal, 04 Jul. 2022

  
• The X chromosome dosage compensation program during the development of cynomolgus monkeys.

  Ikuhiro Okamoto; Tomonori Nakamura; Kotaro Sasaki; Yukihiro Yabuta; Chizuru Iwatani; Hideaki Tsuchiya; Shin-Ichiro Nakamura; Masatsugu Ema; Takuya Yamamoto; Mitinori Saitou

  Science (New York, N.Y.), 19 Nov. 2021

  
• Inherent genomic properties underlie the epigenomic heterogeneity of human induced pluripotent stem cells

  Shihori Yokobayashi; Yukihiro Yabuta; Masato Nakagawa; Keisuke Okita; Bo Hu; Yusuke Murase; Tomonori Nakamura; Guillaume Bourque; Jacek Majewski; Takuya Yamamoto; Mitinori Saitou

  Cell Reports, Nov. 2021

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• In vitro reconstitution of the whole male germ-cell development from mouse pluripotent stem cells.

  Yukiko Ishikura; Hiroshi Ohta; Takuya Sato; Yusuke Murase; Yukihiro Yabuta; Yoji Kojima; Chika Yamashiro; Tomonori Nakamura; Takuya Yamamoto; Takehiko Ogawa; Mitinori Saitou

  Cell stem cell, 01 Sep. 2021, Peer-reviewed

  
• The embryonic ontogeny of the gonadal somatic cells in mice and monkeys.

  Kotaro Sasaki; Akiko Oguchi; Keren Cheng; Yasuhiro Murakawa; Ikuhiro Okamoto; Hiroshi Ohta; Yukihiro Yabuta; Chizuru Iwatani; Hideaki Tsuchiya; Takuya Yamamoto; Yasunari Seita; Mitinori Saitou

  Cell reports, 04 May 2021

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• GATA transcription factors, SOX17 and TFAP2C, drive the human germ-cell specification program.

  Yoji Kojima; Chika Yamashiro; Yusuke Murase; Yukihiro Yabuta; Ikuhiro Okamoto; Chizuru Iwatani; Hideaki Tsuchiya; Masataka Nakaya; Tomoyuki Tsukiyama; Tomonori Nakamura; Takuya Yamamoto; Mitinori Saitou

  Life science alliance, May 2021

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• Cyclosporin A and FGF signaling support the proliferation/survival of mouse primordial germ cell-like cells in vitro†.

  Hiroshi Ohta; Yukihiro Yabuta; Kazuki Kurimoto; Tomonori Nakamura; Yusuke Murase; Takuya Yamamoto; Mitinori Saitou

  Biology of reproduction, 11 Feb. 2021

  
• Capturing Human Trophoblast Development with Naive Pluripotent Stem Cells In Vitro

  Shingo Io; Mio Kabata; Yoshiki Iemura; Katsunori Semi; Nobuhiro Morone; Ikuhiro Okamoto; Tomonori Nakamura; Yoji Kojima; Chizuru Iwatani; Hideaki Tsuchiya; Belinda Kaswandy; Eiji Kondoh; Mitinori Saitou; Takuya Yamamoto; Masaki Mandai; Yasuhiro Takashima

  18 Dec. 2020

  
• Long-term expansion with germline potential of human primordial germ cell-like cells in vitro.

  Yusuke Murase; Yukihiro Yabuta; Hiroshi Ohta; Chika Yamashiro; Tomonori Nakamura; Takuya Yamamoto; Mitinori Saitou

  The EMBO journal, 02 Nov. 2020

  
• Generation of human oogonia from induced pluripotent stem cells in culture

  Chika Yamashiro; Kotaro Sasaki; Shihori Yokobayashi; Yoji Kojima; Mitinori Saitou

  Nature Protocols, Apr. 2020

  
• ZGLP1 is a determinant for the oogenic fate in mice.

  So I Nagaoka; Fumio Nakaki; Hidetaka Miyauchi; Yoshiaki Nosaka; Hiroshi Ohta; Yukihiro Yabuta; Kazuki Kurimoto; Katsuhiko Hayashi; Tomonori Nakamura; Takuya Yamamoto; Mitinori Saitou

  Science (New York, N.Y.), 13 Feb. 2020, Peer-reviewed

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• Induction of the Germ-Cell Fate from Pluripotent Stem Cells in Cynomolgus Monkeys

  Sakai, Y.; Nakamura, T.; Okamoto, I.; Gyobu-Motani, S.; Ohta, H.; Yabuta, Y.; Tsukiyama, T.; Iwatani, C.; Tsuchiya, H.; Ema, M.; Morizane, A.; Takahashi, J. Yamamoto, T.; Saitou, M.

  Biology of Reproduction, Oct. 2019, Peer-reviewed

  
• Germ cell reprogramming.

  Kurimoto K; Saitou M

  Current topics in developmental biology, 2019, Peer-reviewed

  
• Generation of human oogonia from induced pluripotent stem cells in vitro.

  Chika Yamashiro; Kotaro Sasaki; Yukihiro Yabuta; Yoji Kojima; Tomonori Nakamura; Ikuhiro Okamoto; Shihori Yokobayashi; Yusuke Murase; Yukiko Ishikura; Kenjiro Shirane; Hiroyuki Sasaki; Takuya Yamamoto; Mitinori Saitou

  Science (New York, N.Y.), 19 Oct. 2018

  
• mDia1/3 generate cortical F-actin meshwork in Sertoli cells that is continuous with contractile F-actin bundles and indispensable for spermatogenesis and male fertility

  Satoko Sakamoto; Dean Thumkeo; Hiroshi Ohta; Zhen Zhang; Shuangru Huang; Pakorn Kanchanawong; Takayoshi Fuu; Sadanori Watanabe; Kentaro Shimada; Yoshitaka Fujihara; Shosei Yoshida; Masahito Ikawa; Naoki Watanabe; Mitinori Saitou; Shuh Narumiya

  PLoS Biology, Sep. 2018, Peer-reviewed

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• Epigenome regulation during germ cell specification and development from pluripotent stem cells.

  Kurimoto K; Saitou M

  Current opinion in genetics & development, Jun. 2018, Peer-reviewed

  
• Induction of fetal primary oocytes and the meiotic prophase from mouse pluripotent stem cells.

  Miyauchi H; Ohta H; Saitou M

  Methods in cell biology, 2018, Peer-reviewed

  
• Principles for the regulation of multiple developmental pathways by a versatile transcriptional factor, BLIMP1.

  Mitani T; Yabuta Y; Ohta H; Nakamura T; Yamashiro C; Yamamoto T; Saitou M; Kurimoto K

  Nucleic acids research, Dec. 2017, Peer-reviewed

  
• Evolutionarily Distinctive Transcriptional and Signaling Programs Drive Human Germ Cell Lineage Specification from Pluripotent Stem Cells.

  Yoji Kojima; Kotaro Sasaki; Shihori Yokobayashi; Yoshitake Sakai; Tomonori Nakamura; Yukihiro Yabuta; Fumio Nakaki; So Nagaoka; Knut Woltjen; Akitsu Hotta; Takuya Yamamoto; Mitinori Saitou

  Cell stem cell, 05 Oct. 2017, Peer-reviewed

  
• Klf5 maintains the balance of primitive endoderm versus epiblast specification during mouse embryonic development by suppression of Fgf4.

  Azami T; Waku T; Matsumoto K; Jeon H; Muratani M; Kawashima A; Yanagisawa J; Manabe I; Nagai R; Kunath T; Nakamura T; Kurimoto K; Saitou M; Takahashi S; Ema M

  Development (Cambridge, England), Oct. 2017, Peer-reviewed

  
• Fertile offspring from sterile sex chromosome trisomic mice

  Takayuki Hirota; Hiroshi Ohta; Benjamin E. Powell; Shantha K. Mahadevaiah; Obah A. Ojarikre; Mitinori Saitou; James M. A. Turner

  SCIENCE, Sep. 2017, Peer-reviewed

  
• Klf5 maintains the balance of primitive endoderm to epiblast specification during mouse embryonic development by suppression of Fgf4

  Azami, Takuya; Waku, Tsuyoshi; Matsumoto, Ken; Jeon, Hyojung; Muratani, Masafumi; Kawashima, Akihiro; Yanagisawa, Jun; Manabe, Ichiro; Nagai, Ryozo; Kunath, Tilo; Nakamura, Tomonori; Kurimoto, Kazuki; Saitou, Mitinori; Takahashi, Satoru; Ema, Masatsugu

  Development (Cambridge, England), Sep. 2017, Peer-reviewed

  
• Bone morphogenetic protein and retinoic acid synergistically specify female germ-cell fate in mice.

  Miyauchi, H; Ohta, H; Nagaoka, S; Nakaki, F; Sasaki, K; Hayashi, K; Yabuta, Y; Nakamura, T; Yamamoto, T; Saitou, M

  The EMBO Journal, Sep. 2017, Peer-reviewed

  
• Reconstitution of the oocyte nucleolus in mice through a single nucleolar protein, NPM2

  Sugako Ogushi; Kazuo Yamagata; Chikashi Obuse; Keiko Furuta; Teruhiko Wakayama; Martin M. Matzuk; Mitinori Saitou

  JOURNAL OF CELL SCIENCE, Jul. 2017, Peer-reviewed

  
• Clonal variation of human induced pluripotent stem cells for induction into the germ cell fate

  Yokobayashi, Shihori; Okita, Keisuke; Nakagawa, Masato; Nakamura, Tomonori; Yabuta, Yukihiro; Yamamoto, Takuya; Saitou, Mitinori

  BIOLOGY OF REPRODUCTION, Jun. 2017, Peer-reviewed

  
• Single-cell transcriptome of early embryos and cultured embryonic stem cells of cynomolgus monkeys

  Tomonori Nakamura; Yukihiro Yabuta; Ikuhiro Okamoto; Kotaro Sasaki; Chizuru Iwatani; Hideaki Tsuchiya; Mitinori Saitou

  Scientific Data, Jun. 2017, Peer-reviewed

  
• In vitro expansion of mouse primordial germ cell-like cells recapitulates an epigenetic blank slate.

  Ohta H; Kurimoto K; Okamoto I; Nakamura T; Yabuta Y; Miyauchi H; Yamamoto T; Okuno Y; Hagiwara M; Shirane K; Sasaki H; Saitou M

  The EMBO journal, May 2017, Peer-reviewed

  
• Flexible adaptation of male germ cells from female iPSCs of endangered Tokudaia osimensis.

  Honda A; Choijookhuu N; Izu H; Kawano Y; Inokuchi M; Honsho K; Lee AR; Nabekura H; Ohta H; Tsukiyama T; Ohinata Y; Kuroiwa A; Hishikawa Y; Saitou M; Jogahara T; Koshimoto C

  Science advances, May 2017, Peer-reviewed

  
• Discrimination of Stem Cell Status after Subjecting Cynomolgus Monkey Pluripotent Stem Cells to Naive Conversion

  Honda, Arata; Kawano, Yoshihiro; Izu, Haruna; Choijookhuu, Narantsog; Honsho, Kimiko; Nakamura, Tomonori; Yabuta, Yukihiro; Yamamoto, Takuya; Takashima, Yasuhiro; Hirose, Michiko; Sankai, Tadashi; Hishikawa, Yoshitaka; Ogura, Atsuo; Saitou, Mitinori

  SCIENTIFIC REPORTS, Mar. 2017, Peer-reviewed

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• Reconstitution of Female Germ Cell Fate Determination and Meiotic Initiation in Mammals.

  So I Nagaoka; Mitinori Saitou

  Cold Spring Harbor symposia on quantitative biology, 2017, Invited

  
• In Vitro Derivation and Propagation of Spermatogonial Stem Cell Activity from Mouse Pluripotent Stem Cells.

  Ishikura Y; Yabuta Y; Ohta H; Hayashi K; Nakamura T; Okamoto I; Yamamoto T; Kurimoto K; Shirane K; Sasaki H; Saitou M

  Cell reports, Dec. 2016, Peer-reviewed

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• Reconstitution in vitro of the entire cycle of the mouse female germ line

  Orie Hikabe; Nobuhiko Hamazaki; Go Nagamatsu; Yayoi Obata; Yuji Hirao; Norio Hamada; So Shimamoto; Takuya Imamura; Kinichi Nakashima; Mitinori Saitou; Katsuhiko Hayashi

  NATURE, Nov. 2016, Peer-reviewed

  
• The Germ Cell Fate of Cynomolgus Monkeys Is Specified in the Nascent Amnion.

  Kotaro Sasaki; Tomonori Nakamura; Ikuhiro Okamoto; Yukihiro Yabuta; Chizuru Iwatani; Hideaki Tsuchiya; Yasunari Seita; Shinichiro Nakamura; Naoto Shiraki; Tetsuya Takakuwa; Takuya Yamamoto; Mitinori Saitou

  Developmental cell, 24 Oct. 2016

  
• Global Landscape and Regulatory Principles of DNA Methylation Reprogramming for Germ Cell Specification by Mouse Pluripotent Stem Cells.

  Shirane K; Kurimoto K; Yabuta Y; Yamaji M; Satoh J; Ito S; Watanabe A; Hayashi K; Saitou M; Sasaki H

  Developmental cell, Oct. 2016, Peer-reviewed

  
• A developmental coordinate of pluripotency among mice, monkeys and humans

  Nakamura, Tomonori; Okamoto, Ikuhiro; Sasaki, Kotaro; Yabuta, Yukihiro; Iwatani, Chizuru; Tsuchiya, Hideaki; Seita, Yasunari; Nakamura, Shinichiro; Yamamoto, Takuya; Saitou, Mitinori

  NATURE, Sep. 2016, Peer-reviewed

  
• Persistent Requirement and Alteration of the Key Targets of PRDM1 During Primordial Germ Cell Development in Mice.

  Chika Yamashiro; Takayuki Hirota; Kazuki Kurimoto; Tomonori Nakamura; Yukihiro Yabuta; So I Nagaoka; Hiroshi Ohta; Takuya Yamamoto; Mitinori Saitou

  Biology of reproduction, Jan. 2016, Peer-reviewed

  
• Mechanism and Reconstitution In Vitro of Germ Cell Development in Mammals.

  Kurimoto K; Saitou M

  Cold Spring Harbor symposia on quantitative biology, Dec. 2015

  
• Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells.

  Sasaki K; Yokobayashi S; Nakamura T; Okamoto I; Yabuta Y; Kurimoto K; Ohta H; Moritoki Y; Iwatani C; Tsuchiya H; Nakamura S; Sekiguchi K; Sakuma T; Yamamoto T; Mori T; Woltjen K; Nakagawa M; Yamamoto T; Takahashi K; Yamanaka S

  Cell stem cell, Aug. 2015, Peer-reviewed

  
• Quantitative Dynamics of Chromatin Remodeling during Germ Cell Specification from Mouse Embryonic Stem Cells.

  Kazuki Kurimoto; Yukihiro Yabuta; Katsuhiko Hayashi; Hiroshi Ohta; Hiroshi Kiyonari; Tadahiro Mitani; Yoshinobu Moritoki; Kenjiro Kohri; Hiroshi Kimura; Takuya Yamamoto; Yuki Katou; Katsuhiko Shirahige; Mitinori Saitou

  Cell stem cell, 07 May 2015, Peer-reviewed

  
• SC3-seq: a method for highly parallel and quantitative measurement of single-cell gene expression.

  Nakamura T; Yabuta Y; Okamoto I; Aramaki S; Yokobayashi S; Kurimoto K; Sekiguchi K; Nakagawa M; Yamamoto T; Saitou M

  Nucleic acids research, May 2015, Peer-reviewed

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• Quantitative Dynamics of Chromatin Remodeling during Germ Cell Specification from Mouse Embryonic Stem Cells.

  Kurimoto K; Yabuta Y; Hayashi K; Ohta H; Kiyonari H; Mitani T; Moritoki Y; Kohri K; Kimura H; Yamamoto T; Katou Y; Shirahige K; Saitou M

  Cell stem cell, May 2015, Peer-reviewed

  
• CCR1-mediated accumulation of myeloid cells in the liver microenvironment promoting mouse colon cancer metastasis.

  Hirai H; Fujishita T; Kurimoto K; Miyachi H; Kitano S; Inamoto S; Itatani Y; Saitou M; Maekawa T; Taketo MM

  Clinical & experimental metastasis, Dec. 2014, Peer-reviewed

  
• Induction of Primordial Germ Cell-Like Cells From Mouse Embryonic Stem Cells by ERK Signal Inhibition

  Tohru Kimura; Yoshiaki Kaga; Hiroshi Ohta; Mika Odamoto; Yoichi Sekita; Kunpeng Li; Noriko Yamano; Keita Fujikawa; Ayako Isotani; Norihiko Sasaki; Masashi Toyoda; Katsuhiko Hayashi; Masaru Okabe; Takashi Shinohara; Mitinori Saitou; Toru Nakano

  STEM CELLS, Oct. 2014, Peer-reviewed

  
• Paternal nucleosomes: are they retained in developmental promoters or gene deserts?

  Saitou M; Kurimoto K

  Developmental cell, Jul. 2014

  
• The two active X chromosomes in female ESCs block exit from the pluripotent state by modulating the ESC signaling network.

  Schulz EG; Meisig J; Nakamura T; Okamoto I; Sieber A; Picard C; Borensztein M; Saitou M; Blüthgen N; Heard E

  Feb. 2014, Peer-reviewed

  
• Cell-to-cell expression variability followed by signal reinforcement progressively segregates early mouse lineages

  Y. Ohnishi; W. Huber; A. Tsumura; M. Kang; P. Xenopoulos; K. Kurimoto; A.K. Oleå; M.J. Araúzo-Bravo; M. Saitou; A.-K. Hadjantonakis; T. Hiiragi

  Nature Cell Biology, Jan. 2014, Peer-reviewed

  
• A mesodermal factor, T, specifies mouse germ cell fate by directly activating germline determinants

  S. Aramaki; K. Hayashi; K. Kurimoto; H. Ohta; Y. Yabuta; H. Iwanari; Y. Mochizuki; T. Hamakubo; Y. Kato; K. Shirahige; M. Saitou

  Developmental Cell, Dec. 2013, Peer-reviewed

  
• Induction of mouse germ-cell fate by transcription factors in vitro

  F. Nakaki; K. Hayashi; H. Ohta; K. Kurimoto; Y. Yabuta; M. Saitou

  Nature, Sep. 2013, Peer-reviewed

  
• A replication-dependent passive mechanism modulates DNA demethylation in mouse primordial germ cells.

  Ohno R; Nakayama M; Naruse C; Okashita N; Takano O; Tachibana M; Asano M; Saitou M; Seki Y

  Development (Cambridge, England), Jul. 2013, Peer-reviewed

  
• PRDM14 Ensures Naive Pluripotency through Dual Regulation of Signaling and Epigenetic Pathways in Mouse Embryonic Stem Cells.

  Yamaji M; Ueda J; Hayashi K; Ohta H; Yabuta Y; Kurimoto K; Nakato R; Yamada Y; Shirahige K; Saitou M

  Cell Stem Cell, Mar. 2013, Peer-reviewed

  
• Replication-coupled passive DNA demethylation for the erasure of genome imprints in mice

  S. Kagiwada; K. Kurimoto; T. Hirota; M. Yamaji; M. Saitou

  EMBO Journal, Feb. 2013, Peer-reviewed

  
• Tsix RNA and the germline factor, PRDM14, link X reactivation and stem cell reprogramming

  Payer, B; Rosenberg, M; Yamaji, M; Yabuta, Y; Koyanagi-Aoi, M; Hayashi, K; Yamanaka, S; Saitou, M; Lee, J.T

  Molecular Cell, 2013, Peer-reviewed

  
• Offspring from oocytes derived from in vitro primordial germ cell-like cells in mice

  K. Hayashi; S. Ogushi; K. Kurimoto; S. Shimamoto; H. Ohta; M. Saitou

  Science, Nov. 2012, Peer-reviewed

  
• Implication of DNA Demethylation and Bivalent Histone Modification for Selective Gene Regulation in Mouse Primordial Germ Cells

  Kentaro Mochizuki; Makoto Tachibana; Mitinori Saitou; Yuko Tokitake; Yasuhisa Matsui

  PLOS ONE, Sep. 2012, Peer-reviewed

  
• Locus- and domain-dependent control of DNA methylation at mouse B1 retrotransposons during male germ cell development.

  Kenji Ichiyanagi; Yufeng Li; Toshiaki Watanabe; Tomoko Ichiyanagi; Kei Fukuda; Junko Kitayama; Yasuhiro Yamamoto; Satomi Kuramochi-Miyagawa; Toru Nakano; Yukihiro Yabuta; Yoshiyuki Seki; Mitinori Saitou; Hiroyuki Sasaki

  Genome research, Dec. 2011, Peer-reviewed

  
• Loss of Heterochromatin Protein 1 Gamma Reduces the Number of Primordial Germ Cells via Impaired Cell Cycle Progression in Mice

  Kanae Abe; Chie Naruse; Tomoaki Kato; Takumi Nishiuchi; Mitinori Saitou; Masahide Asano

  BIOLOGY OF REPRODUCTION, Nov. 2011, Peer-reviewed

  
• Condensins I and II are essential for construction of bivalent chromosomes in mouse oocytes

  Jibak Lee; Sugako Ogushi; Mitinori Saitou; Tatsuya Hirano

  MOLECULAR BIOLOGY OF THE CELL, Sep. 2011, Peer-reviewed

  
• Involvement of mouse nucleoplasmin 2 in the decondensation of sperm chromatin after fertilization

  Azusa Inoue; Sugako Ogushi; Mitinori Saitou; Masataka G. Suzuki; Fugaku Aoki

  Biology of Reproduction, 01 Jul. 2011, Peer-reviewed

  
• A global single-cell cDNA amplification method for quantitative microarray analysis.

  K. Kurimoto; M. Saitou

  Methods in molecular biology (Clifton, N.J.), 2011, Peer-reviewed

  
• Survival and death of epiblast cells during embryonic stem cell derivation revealed by long-term live-cell imaging with an Oct4 reporter system

  Kazuo Yamagata; Jun Ueda; Eiji Mizutani; Mitinori Saitou; Teruhiko Wakayama

  DEVELOPMENTAL BIOLOGY, Oct. 2010, Peer-reviewed

  
• Conditional knockdown of Nanog induces apoptotic cell death in mouse migrating primordial germ cells

  S. Yamaguchi; K. Kurimoto; Y. Yabuta; H. Sasaki; N. Nakatsuji; M. Saitou; T. Tada

  Development, Dec. 2009, Peer-reviewed

  
• Male Germline and Embryonic Stem Cell Lines from NOD Mice: Efficient Derivation of GS Cells from a Nonpermissive Strain for ES Cell Derivation

  Ohta H; Ohinata Y; Ikawa M; Morioka Y; Sakaide Y; Saitou M; Kanagawa O; Wakayama T

  Biol Reprod, Oct. 2009, Peer-reviewed

  
• Specification of the germ cell lineage in mice: A process orchestrated by the PR-domain proteins, Blimp1 and Prdm14

  K. Kurimoto; M. Yamaji; Y. Seki; M. Saitou

  Cell Cycle, Nov. 2008

  
• Single-cell gene profiling defines differential progenitor subclasses in mammalian neurogenesis

  A. Kawaguchi; T. Ikawa; T. Kasukawa; H.R. Ueda; K. Kurimoto; M. Saitou; F. Matsuzaki

  Development, Sep. 2008, Peer-reviewed

  
• The maternal nucleolus is essential for early embryonic development in mammals

  Sugako Ogushi; Chiara Palmieri; Helena Fulka; Mitinori Saitou; Takashi Miyano; Josef Fulka

  SCIENCE, Feb. 2008, Peer-reviewed

  
• Single-cell cDNA high-density oligonucleotide microarray analysis: Detection of individual cell types and properties in complex biological processes

  M. Saitou; Y. Yabuta; K. Kurimoto

  Reproductive BioMedicine Online, Jan. 2008, Peer-reviewed

  
• Cellular dynamics associated with the genome-wide epigenetic reprogramming in migrating primordial germ cells in mice.

  Seki Y; Yamaji M; Yabuta Y; Sano M; Shigeta M; Matsui Y; Saga Y; Tachibana M; Shinkai Y; Saitou M

  Development, 2007, Peer-reviewed

  
• Global single-cell cDNA amplification to provide a template for representative high-density oligonucleotide microarray analysis

  K. Kurimoto; Y. Yabuta; Y. Ohinata; M. Saitou

  Nature Protocols, 2007, Peer-reviewed

  
• Gene expression dynamics during germline specification in mice identified by quantitative single-cell gene expression profiling

  Y. Yabuta; K. Kurimoto; Y. Ohinata; Y. Seki; M. Saitou

  Biology of Reproduction, Nov. 2006, Peer-reviewed

  
• Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland

  Valerie Horsley; Donal O'Carroll; Reuben Tooze; Yasuhide Ohinata; Mitinori Saitou; Tetyana Obukhanych; Michel Nussenzweig; Alexander Tarakhovsky; Elaine Fuchs

  CELL, Aug. 2006, Peer-reviewed

  
• An improved single-cell cDNA amplification method for efficient high-density oligonucleotide microarray analysis

  K. Kurimoto; Y. Yabuta; Y. Ohinata; Y. Ono; K.D. Uno; R.G. Yamada; H.R. Ueda; M. Saitou

  Nucleic Acids Research, 2006, Peer-reviewed

  
• Epigenetic reprogramming in mouse pre-implantation development and primordial germ cells. Development, 139, 15-31, (2012).

  Saitou, M; Kagiwada, S; Kurimoto, K

  2012, Peer-reviewed

  
• Reconstitution of the Mouse Germ Cell Specification Pathway in Culture by Pluripotent Stem Cells

  Katsuhiko Hayashi; Hiroshi Ohta; Kazuki Kurimoto; Shinya Aramaki; Mitinori Saitou

  CELL, Aug. 2011, Peer-reviewed

  
• Drug-Inducible Gene Recombination by the Dppa3-MER Cre MER Transgene in the Developmental Cycle of the Germ Cell Lineage in Mice

  Takayuki Hirota; Hiroshi Ohta; Mayo Shigeta; Hitoshi Niwa; Mitinori Saitou

  BIOLOGY OF REPRODUCTION, Aug. 2011, Peer-reviewed

  
• TDRD5 is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis in mice

  Yukihiro Yabuta; Hiroshi Ohta; Takaya Abe; Kazuki Kurimoto; Shinichiro Chuma; Mitinori Saitou

  JOURNAL OF CELL BIOLOGY, Mar. 2011, Peer-reviewed

  Access this paper :

  
• Functional reconstruction of NANOS3 expression in the germ cell lineage by a novel transgenic reporter reveals distinct subcellular localizations of NANOS3

  Masashi Yamaji; Takashi Tanaka; Mayo Shigeta; Shinichiro Chuma; Yumiko Saga; Mitinori Saitou

  REPRODUCTION, Feb. 2010, Peer-reviewed

  
• Germ cell specification in mice: signaling, transcription regulation, and epigenetic consequences

  Mitinori Saitou; Masashi Yamaji

  REPRODUCTION, Jun. 2010, Peer-reviewed

  
• The Nucleolus in the Mouse Oocyte is Required for the Early Step of Both Female and Male Pronucleus Organization

  Sugako Ogushi; Mitinori Saitou

  JOURNAL OF REPRODUCTION AND DEVELOPMENT, Oct. 2010, Peer-reviewed

  
• Single-cell cDNA microarray profiling of complex biological processes of differentiation

  Kazuki Kurimoto; Mitinori Saitou

  CURRENT OPINION IN GENETICS & DEVELOPMENT, Oct. 2010, Peer-reviewed

  Access this paper :

  
• A Signaling Principle for the Specification of the Germ Cell Lineage in Mice

  Yasuhide Ohinata; Hiroshi Ohta; Mayo Shigeta; Kaori Yamanaka; Teruhiko Wakayama; Mitinori Saitou

  CELL, May 2009, Peer-reviewed

  
• Germ cell specification in mice. Current Opinion in Genetics and Development, 19, 386-395, (2009).

  Saitou, M

  2009, Peer-reviewed

  
• Complex genome-wide transcription dynamics orchestrated by Blimp1 for the specification of the germ cell lineage in mice

  Kazuki Kurimoto; Yukihiro Yabuta; Yasuhide Ohinata; Mayo Shigeta; Kaori Yamanaka; Mitinori Saitou

  GENES & DEVELOPMENT, Jun. 2008, Peer-reviewed

  
• Critical function of Prdm14 for the establishment of the germ cell lineage in mice

  Masashi Yamaji; Yoshiyuki Seki; Kazuki Kurimoto; Yukihiro Yabuta; Mihoko Yuasa; Mayo Shigeta; Kaori Yamanaka; Yasuhide Ohinata; Mitinori Saitou

  NATURE GENETICS, Aug. 2008, Peer-reviewed

  
• A comprehensive, non-invasive visualization of primordial germ cell development in mice by the Prdm1-mVenus and Dppa3-ECFP double transgenic reporter

  Yasuhide Ohinata; Mitsue Sano; Mayo Shigeta; Kaori Yamanaka; Mitinori Saitou

  REPRODUCTION, Oct. 2008, Peer-reviewed

  

Misc.

• Generation of human oogonia from induced pluripotent stem cells in vitro

  Chika Yamashiro; Kotaro Sasaki; Yukihiro Yabuta; Yoji Kojima; Tomonori Nakamura; Ikuhiro Okamoto; Shihori Yokobayashi; Yusuke Murase; Yukiko Ishikura; Kenjiro Shirane; Hiroyuki Sasaki; Takuya Yamamoto; Mitinori Saitou

  Obstetrical and Gynecological Survey, 01 Mar. 2019

  
• A unique role of maternal nucleolus in early mammalian development

  Sugako Ogushi; Takashi Miyano; Mitinori Saitou; Josef Fulka

  JOURNAL OF REPRODUCTION AND DEVELOPMENT, Feb. 2008

  
• Reconstituting oogenesis in vitro: Recent progress and future prospects

  So I. Nagaoka; Mitinori Saitou; Kazuki Kurimoto

  Current Opinion in Endocrine and Metabolic Research, 01 Jun. 2021

  

Awards

• 20 Nov. 2024

  慶應医学賞
• Jul. 2020

  EMBO Associate Member
• Jun. 2020

  ISSCR Momentum Award
• Apr. 2020

  恩賜賞・日本学士院賞
• Mar. 2020

  上原賞
• Jan. 2020

  朝日賞
• Nov. 2018

  持田記念学術賞
• Nov. 2016

  武田医学賞
• Feb. 2014

  日本学士院学術奨励賞
• Feb. 2014

  日本学術振興会賞
• Dec. 2013

  ナイスステップな研究者2013
• Nov. 2013

  大阪科学賞
• Apr. 2013

  読売テクノフォーラム　ゴールド・メダル賞
• Apr. 2009

  文部科学大臣表彰若手科学者賞

External funds: Kakenhi

• Elucidation of the mechanism for human oocyte development based on its in vitro reconstitution

  Grant-in-Aid for Specially Promoted Research

  Biological Sciences

  Kyoto University

  斎藤 通紀

  From 01 Apr. 2022, To 31 Mar. 2027, Granted

  ヒト発生;生殖細胞;卵母細胞;iPS細胞;発生・分化;ヒト生殖細胞;減数分裂;ゲノム;エピゲノム

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H04920/
• Mechanism and Reconstitution In Vitro of Human Germ Cell Development

  Grant-in-Aid for Specially Promoted Research

  Biological Sciences

  Kyoto University

  Mitinori Saitou

  From 25 Apr. 2017, To 31 Mar. 2022, Project Closed

  生殖細胞;iPS細胞;エピゲノムリプログラミング;卵母細胞;試験管内誘導;ヒト発生生物学;発生・分化;再生医学;ゲノム;発現制御;進化;ヒト;発生;試験管内再構成;減数分裂;霊長類;マウス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H06098/
• 癌転移を制御する骨髄由来細胞の細胞系譜決定

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  前川 平

  From 01 Apr. 2010, To 31 Mar. 2011, Project Closed

  癌転移;骨髄由来細胞;細胞系譜

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22650227/
• Unveiling the mechanism of action of Blimp1, a transcriptional regulator that governs fates and homeostasis of diverse cell lineage

  Grant-in-Aid for Young Scientists (S)

  Kyoto University

  Mitinori SAITOU

  From 01 Apr. 2009, To 31 Mar. 2014, Project Closed

  発生・分化;遺伝子;ゲノム;シグナル伝達;再生医学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21677003/
• The mechanism of the acquisition of germ cell-specific epigenome and its reconstruction in vitro.

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University;The Institute of Physical and Chemical Research

  Mitinori SAITOU

  From 01 Apr. 2008, To 31 Mar. 2013, Project Closed

  発生・分化;遺伝子;ゲノム;シグナル伝達;再生医学;生殖細胞;Blimpl;Prdm14;エピゲノム;Bmp4;エピブラスト;細胞培養;ES細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-20062011/
• 単一細胞マイクロアレイ法による生命現象解明の基盤創出

  Grant-in-Aid for Scientific Research (B)

  The Institute of Physical and Chemical Research

  斎藤 通紀

  From 01 Apr. 2007, To 31 Mar. 2010, Project Closed

  単一細胞;遺伝子発現;マイクロアレイ;初期発生;胚盤胞;生殖細胞;ジーンタゲティング;細胞分化

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19370098/
• マウス生殖細胞形成を規定する遺伝子発現ダイナミクスとその破綻機構の解明

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  The Institute of Physical and Chemical Research

  斎藤 通紀

  From 01 Apr. 2006, To 31 Mar. 2008, Project Closed

  単一細胞;生殖細胞;遺伝子発現;マイクロアレイ;Blimp1;Prdm14;エピゲノム;多能性;全能性;ゲノムリプログラミング;ES細胞;体細胞;システム生物学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18051018/
• 決定直後マウス生殖細胞に発現する遺伝子の網羅的解析

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  The Institute of Physical and Chemical Research

  斎藤 通紀

  From 01 Apr. 2004, To 31 Mar. 2006, Project Closed

  生殖細胞;単一細胞;全能性;ゲノムリプログラミング;マイクロアレイ;ES細胞;体細胞;システム生物学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16045217/

External funds: others

• ヒト生物学高等研究拠点 (2022年度分)

  文部科学省, 国際研究拠点形成促進事業費補助金

  From 01 Apr. 2022, To 31 Mar. 2023

  代表
• ヒト生物学高等研究拠点 (2021年度分)

  文部科学省, 国際研究拠点形成促進事業費補助金

  From 01 Apr. 2021, To 31 Mar. 2022

  代表
• ヒト生物学高等研究拠点 （2020年度分）

  国際研究拠点形成促進事業費補助金

  From 01 Apr. 2020, To 31 Mar. 2021

  斎藤 通紀
• ヒト生物学高等研究拠点 （2019年度分）

  国際研究拠点形成促進事業費補助金

  From 01 Apr. 2019, To 31 Mar. 2020

  斎藤　通紀
• ヒト生物学高等研究拠点 （平成30年度分）

  国際研究拠点形成促進事業費補助金

  From 01 Apr. 2018, To 31 Mar. 2019

  斎藤 通紀

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  Practical Course on Histology

  B006, Fall, Faculty of Medicine, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Histology

  E003, Fall, Graduate School of Medicine, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Histology

  B005, Fall, Faculty of Medicine, 1.5
• From 01 Apr. 2023, To 31 Mar. 2024

  Practical Course on Histology

  B006, Fall, Faculty of Medicine, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Histology

  E003, Fall, Graduate School of Medicine, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Histology

  B005, Fall, Faculty of Medicine, 1.5
• From 01 Apr. 2022, To 31 Mar. 2023

  Histology

  B005, Fall, Faculty of Medicine, 1.5
• From 01 Apr. 2022, To 31 Mar. 2023

  Practical Course on Histology

  B006, Fall, Faculty of Medicine, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Laboratory Course in Histology

  L020, Fall, Faculty of Medicine, 0
• From 01 Apr. 2022, To 31 Mar. 2023

  Histology

  L010, Fall, Faculty of Medicine, 0
• From 01 Apr. 2022, To 31 Mar. 2023

  Histology

  E003, Fall, Graduate School of Medicine, 2
• From Apr. 2011, To Mar. 2012

  組織学

  Fall, 医学研究科
• From Apr. 2012, To Mar. 2013

  Laboratory visit

  Spring, 医学研究科
• From Apr. 2012, To Mar. 2013

  Histology

  Fall, 医学研究科
• From Apr. 2013, To Mar. 2014

  Lecture in Histology

  Fall, 医学部
• From Apr. 2013, To Mar. 2014

  Practice Course in Histology

  Fall, 医学部
• From Apr. 2013, To Mar. 2014

  Histology

  Fall, 医学研究科
• From Apr. 2014, To Mar. 2015

  Histology

  Fall, 医学部
• From Apr. 2014, To Mar. 2015

  Laboratory Course in Histology

  Fall, 医学部
• From Apr. 2014, To Mar. 2015

  Histology

  Fall, 医学研究科
• From Apr. 2014, To Mar. 2015

  Frontier in Life Sciences

  Year-long, 生命科学研究科
• From Apr. 2015, To Mar. 2016

  Histology

  Fall, 医学部
• From Apr. 2015, To Mar. 2016

  Laboratory Course in Histology

  Fall, 医学部
• From Apr. 2015, To Mar. 2016

  Frontiers of Biology

  Spring, 全学共通科目
• From Apr. 2015, To Mar. 2016

  Histology

  Fall, 医学研究科
• From Apr. 2016, To Mar. 2017

  Histology

  Fall, 医学部
• From Apr. 2016, To Mar. 2017

  Laboratory Course in Histology

  Fall, 医学部
• From Apr. 2016, To Mar. 2017

  Frontiers of Biology

  Spring, 全学共通科目
• From Apr. 2016, To Mar. 2017

  Histology

  Fall, 医学研究科
• From Apr. 2017, To Mar. 2018

  Histology

  Fall, 医学部
• From Apr. 2017, To Mar. 2018

  Laboratory Course in Histology

  Fall, 医学部
• From Apr. 2017, To Mar. 2018

  Histology

  Fall, 医学部
• From Apr. 2017, To Mar. 2018

  Practical Course on Histology

  Fall, 医学部
• From Apr. 2017, To Mar. 2018

  Histology

  Fall, 医学研究科
• From Apr. 2018, To Mar. 2019

  Histology

  Fall, 医学部
• From Apr. 2018, To Mar. 2019

  Laboratory Course in Histology

  Fall, 医学部
• From Apr. 2018, To Mar. 2019

  Histology

  Fall, 医学部
• From Apr. 2018, To Mar. 2019

  Practical Course on Histology

  Fall, 医学部
• From Apr. 2018, To Mar. 2019

  Histology

  Fall, 医学研究科
• From Apr. 2019, To Mar. 2020

  Histology

  Fall, 医学部
• From Apr. 2019, To Mar. 2020

  Laboratory Course in Histology

  Fall, 医学部
• From Apr. 2019, To Mar. 2020

  Histology

  Fall, 医学部
• From Apr. 2019, To Mar. 2020

  Practical Course on Histology

  Fall, 医学部
• From Apr. 2019, To Mar. 2020

  Histology

  Fall, 医学研究科
• From Apr. 2020, To Mar. 2021

  Histology

  Fall, 医学部
• From Apr. 2020, To Mar. 2021

  Laboratory Course in Histology

  Fall, 医学部
• From Apr. 2020, To Mar. 2021

  Histology

  Fall, 医学部
• From Apr. 2020, To Mar. 2021

  Practical Course on Histology

  Fall, 医学部
• From Apr. 2020, To Mar. 2021

  Histology

  Fall, 医学研究科
• From Apr. 2021, To Mar. 2022

  Histology

  Fall, 医学部
• From Apr. 2021, To Mar. 2022

  Laboratory Course in Histology

  Fall, 医学部
• From Apr. 2021, To Mar. 2022

  Histology

  Fall, 医学部
• From Apr. 2021, To Mar. 2022

  Practical Course on Histology

  Fall, 医学部
• From Apr. 2021, To Mar. 2022

  Histology

  Fall, 医学研究科

Participation in PhD Defense

• Synergistic involvement of the NZF domains of the LUBAC accessory subunits HOIL-1L and SHARPIN in the regulation of LUBAC function

  TODA YUSUKE, Graduate School of Medicine, Sub-chief Examiner

  24 Mar. 2025
• A highly sensitive screening system　to evaluate the reversibility of neuroendocrine prostate cancer to prostate adenocarcinoma

  FUKUI TOMOHIRO, Graduate School of Medicine, Sub-chief Examiner

  24 Mar. 2025
• An atlas of transcribed enhancers across helper T cell diversity for decoding human diseases

  OGUCHI AKIKO, Graduate School of Medicine, Sub-chief Examiner

  23 Jan. 2025
• EBF1 limits the numbers of cochlear hair and supporting cells and forms the scala tympani and spiral limbus during inner ear development

  KAGOSHIMA HIROKI, Graduate School of Medicine, Chief Examiner

  23 May 2024
• Simultaneous binding of bFGF to both FGFR and integrin maintains properties of primed human induced pluripotent stem cells

  Cheng Yu Shen, Graduate School of Medicine, Sub-chief Examiner

  23 May 2024

Part-time lecturer

• From 01 Apr. 2022, To 31 Mar. 2023

  研究方法論

  岡山大学大学院, 医歯薬学総合研究科
• From 01 Apr. 2024, To 31 Mar. 2025

  東京大学大学院

Administration

School management (title, position)

• From 01 Apr. 2024, To 31 Mar. 2026

  設備整備・共用促進委員会 委員
• 経費削減・有効利用プロジェクトチーム-委員
• 全学共通教育システム委員会-委員
• From 01 Apr. 2018

  大学評価委員会点検・評価実行委員会 委員
• From 01 Oct. 2014, To 30 Sep. 2018

  施設整備委員会 6号委員
• From 01 Apr. 2018, To 31 Mar. 2019

  大学評価委員会点検・評価実行委員会 委員
• From 01 Apr. 2018, To 31 Mar. 2019

  臨床研究審査委員会 委員

Faculty management (title, position)

• 解剖センター運営委員会-委員
• （論文調査委員）選定委員会-委員
• 外国語試問委員会‐委員、委員長
• 遺伝専門小委員会-委員
• 共用試験委員会-委員
• 医学図書館運営委員会-委員
• 国際交流委員会-委員
• カリキュラム企画委員会-委員
• 研究科運営委員会-委員
• 研究科長（学部長）協力委員
• 医学研究科・医学部放射性同位元素等管理委員会
• From 01 Oct. 2016, To 30 Sep. 2018

  医学研究科・医学部動物実験委員会
• From 01 Apr. 2018, To 31 Mar. 2020

  動物実験施設管理委員会（医学研究科）
• 放射性同位元素等管理委員会
• From 01 Oct. 2014, To 30 Sep. 2018

  間接経費使途検討委員会
• From 01 Apr. 2018, To 31 Mar. 2020

  大学評価部局委員会（医学研究科）
• From 01 Apr. 2018, To 31 Mar. 2020

  学務委員会（医学研究科）
• From 01 Apr. 2016, To 31 Mar. 2020

  寄附講座運営委員会（創薬医学）
• From 01 Apr. 2016, To 31 Mar. 2020

  寄附講座運営委員会（免疫ゲノム医学）
• From 01 Apr. 2017, To 31 Mar. 2021

  将来計画検討委員会（医学研究科）
• From 01 Apr. 2017, To 31 Mar. 2019

  京都大学大学院医学研究科・医学部及び医学部附属病院医の倫理委員会　委員
• From 01 Apr. 2017, To 31 Mar. 2019

  京都大学特定認定再生医療等委員会　委員
• From 01 Apr. 2017, To 31 Mar. 2019

  総合博物館運営委員会　委員
• From 01 Jan. 2018, To 31 Dec. 2019

  教育研究支援基金(KMS-FUND)委員会（医学研究科）
• From 01 Apr. 2017, To 31 Mar. 2021

  入学者選抜方法検討委員会（医学研究科）
• From 01 Apr. 2018, To 31 Mar. 2019

  京都大学臨床研究審査委員会
• From 18 Feb. 2019, To 31 Mar. 2019

  京都大学医学部附属病院臨床研究ステージアップ検討会議委員１
• From 18 Mar. 2019, To 31 May 2019

  京都大学医学部附属病院臨床研究ステージアップ検討会議委員２
• From 01 Apr. 2019, To 31 Mar. 2021

  人事連絡委員会（医学研究科）
• From 01 Oct. 2018, To 30 Sep. 2020

  動物実験委員会（医学研究科）
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• From 01 Dec. 2019, To 31 Mar. 2026

  大学院横断教育プログラム推進センターメディカルイノベーション卓越大学院教授会構成員
• From 30 Oct. 2018, To 29 Oct. 2023

  高等研究院ヒト生物学高等研究拠点長
• From 01 Jan. 2022, To 31 Dec. 2023

  京都大学医学部教育研究支援基金委員会委員
• From 30 Oct. 2023, To 31 Mar. 2028

  高等研究院ヒト生物学高等研究拠点長