Basic Information

Faculty

• Faculty of Engineering

Email Address

• Email Address

  mu.huiying.3hkyoto-u.ac.jp

Academic Degree

• 23 Mar. 2021

  京都大学博士（工学）

Academic Resume (Graduate Schools)

• 京都大学, 工学研究科, 物質エネルギー化学専攻, 修了

ID,URL

• ORCID ID

  0009-0006-1532-910X

• J-Global ID

  202301000969001762

• Researcher number

  80967399

researchmap URL

• https://researchmap.jp/1641251111

Research

Papers

• Structure-Dependent Modulation of Light-Induced Membrane Permeabilization by Photoresponsive Tetraphenylethene Derivatives Revealed through Multiscale Simulations and Cellular Experiments.

  Reo Kadowaki; Yuichiro Mori; Daniel Tianhou Zhang; Wenting Huo; Huiying Mu; Koji Miki; Kouichi Ohe; Wataru Shinoda

  ACS applied bio materials, 20 Jul. 2026, Peer-reviewed

  
• Synthesis and Reductive Aromatization of Perfluoro Nickel Phthalocyanine Precursor Having Two Methoxy Groups on Adjacent Pyrrole Rings

  K Nogita; K Miki; H Mu; K Ohe

  ASIAN JOURNAL OF ORGANIC CHEMISTRY, Jul. 2025, Peer-reviewed

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• A Reductively Activatable Phototheranostic Agent Based on a Water-Soluble Nickel Naphthalocyanine Precursor

  K Nogita; Y Kataoka; T Sugahara; K Miki; HY Mu; K Ohe

  CHEMISTRY-A EUROPEAN JOURNAL, Jun. 2025, Peer-reviewed

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• Fast tumor imaging using pH-responsive aggregation of cyanine dyes with rapid clearance

  Huiying Mu; Shuai Shao; Bingquan Wu; Koji Miki; Minoru Kobayashi; Hiroshi Harada; Kouichi Ohe

  Sensors and Actuators B: Chemical, Aug. 2024, Peer-reviewed, Lead author

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• AIE‐ESIPT Photoluminescent Probe Based on 3‐(3‐Hydroxypyridin‐2‐yl)isoquinolin‐4‐ol for the Detection of Intracellular Hydrogen Peroxide

  Wenting Huo; Kohei Takayama; Koji Miki; Kohei Nogita; Shuai Shao; Ayako Suzuki; Takashi Morimoto; Huiying Mu; Kouichi Ohe

  Chemistry – A European Journal, 27 May 2024, Peer-reviewed

  
• Dual-responsive near-infrared turn-on fluorescent probe for cancer stem cell-specific visualization

  Koji Miki; Masahiro Oe; Kanae Suzuki; Koki Miki; Huiying Mu; Yoshimi Kato; Mayumi Iwatake; Hiroshi Yukawa; Yoshinobu Baba; Yoshifumi Ueda; Yasuo Mori; Kouichi Ohe

  Journal of Materials Chemistry B, 2024, Peer-reviewed

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• Light-controllable cell-membrane disturbance for intracellular delivery

  W Huo; K Miki; H Mu; T Osawa; H Yamaguma; Y Kasahara; S Obika; Y Kawaguchi; H Hirose; S Futaki; Y Miyazaki; W Shinoda; S Akai; K Ohe

  JOURNAL OF MATERIALS CHEMISTRY B, May 2024, Peer-reviewed

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• A reductively convertible nickel phthalocyanine precursor as a biological thiol-responsive turn-on photoacoustic contrast agent

  K Nogita; T Sugahara; K Miki; HY Mu; M Kobayashi; H Harada; K Ohe

  CHEMICAL COMMUNICATIONS, Feb. 2024, Peer-reviewed

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• Photoacoustic signal enhancement of Al- and Si-Phthalocyanines caused by photoinduced cleavage of water-soluble axial ligand

  Kohei Nogita; KOJI MIKI; Naoto Imaizumi; Masahiro Oe; Huiying Mu; Kouichi Ohe

  Journal of Photochemistry and Photobiology A: Chemistry, Apr. 2023

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• Steric Control in Activator-Induced Nucleophilic Quencher Detachment-Based Probes: High-Contrast Imaging of Aldehyde Dehydrogenase 1A1 in Cancer Stem Cells

  M Oe; K Suzuki; K Miki; HY Mu; K Ohe

  CHEMPLUSCHEM, Nov. 2022, Peer-reviewed

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• MMP-2-Activatable Photoacoustic Tumor Imaging Probes Based on Al- and Si-Naphthalocyanines

  KOJI MIKI; Naoto Imaizumi; Kohei Nogita; Masahiro Oe; Huiying Mu; Wenting Huo; Hiroshi Harada; Kouichi Ohe

  Bioconjugate Chemistry, 18 Aug. 2021

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• Dual-Stimuli-Responsive Probes for Detection of Ovarian Cancer Cells and Quantification of Both pH and Enzyme Activity

  Wenting Huo; Koji Miki; Daisuke Tokunaga; Huiying Mu; Masahiro Oe; Hiroshi Harada; Kouichi Ohe

  Bulletin of the Chemical Society of Japan, 15 Aug. 2021

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• pH-Activatable Cyanine Dyes for Selective Tumor Imaging Using Near-Infrared Fluorescence and Photoacoustic Modalities

  Huiying Mu; KOJI MIKI; Hiroshi Harada; Kouki Tanaka; Kohei Nogita; Kouichi Ohe

  ACS Sensors, 22 Jan. 2021

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• Substituted meso-vinyl-BODIPY as thiol-selective fluorogenic probes for sensing unfolded proteins in the endoplasmic reticulum

  Huiying Mu; Koji Miki; Takuya Kubo; Koji Otsuka; Kouichi Ohe

  Chemical Communications, 2021

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• Aluminum naphthalocyanine conjugate as an MMP-2-activatable photoacoustic probe for in vivo tumor imaging

  Koji Miki; Naoto Imaizumi; Kohei Nogita; Masahiro Oe; Huiying Mu; Wenting Huo; Kouichi Ohe

  Methods in Enzymology, 2021

  
• pH Responsiveness of Near-infrared Fluorescent Cyanine Dyes Encapsulated in Self-assemblies Composed of Various Amphiphiles

  Huiying Mu; Koji Miki; Yuki Takahashi; Naoto Teshima; Masahiro Oe; Kentaro Kojima; Kouichi Ohe

  Chemistry Letters, 05 Sep. 2018

  
• pH-Responsive Cy5 dyes having nucleophilic substituents for molecular imaging

  Masahiro Oe; Koji Miki; Huiying Mu; Hiroshi Harada; Akiyo Morinibu; Kouichi Ohe

  Tetrahedron Letters, Aug. 2018

  
• d-PET-controlled “off-on” Polarity-sensitive Probes for Reporting Local Hydrophilicity within Lysosomes

  Hao Zhu; Jiangli Fan; Huiying Mu; Tao Zhu; Zhen Zhang; Jianjun Du; Xiaojun Peng

  Scientific Reports, 21 Oct. 2016

  
• Recognition of HClO in Live Cells with Separate Signals Using a Ratiometric Fluorescent Sensor with Fast Response

  Jiangli Fan; Huiying Mu; Hao Zhu; Jianjun Du; Na Jiang; Jingyun Wang; Xiaojun Peng

  Industrial & Engineering Chemistry Research, 16 Sep. 2015

  
• Ratiometric Fluorescence Imaging of Cellular Polarity: Decrease in Mitochondrial Polarity in Cancer Cells

  Na Jiang; Jiangli Fan; Feng Xu; Xiaojun Peng; Huiying Mu; Jingyun Wang; Xiaoqing Xiong

  Angewandte Chemie International Edition, 16 Feb. 2015

  
• A Nile blue based infrared fluorescent probe: imaging tumors that over-express cyclooxygenase-2

  Benhua Wang; Jiangli Fan; Xianwu Wang; Hao Zhu; Jingyun Wang; Huiying Mu; Xiaojun Peng

  Chemical Communications, 2015

  
• Light up ClO⁻in live cells using an aza-coumarin based fluorescent probe with fast response and high sensitivity

  Jiangli Fan; Huiying Mu; Hao Zhu; Jingyun Wang; Xiaojun Peng

  The Analyst, 2015

  
• An “Enhanced PET”-Based Fluorescent Probe with Ultrasensitivity for Imaging Basal and Elesclomol-Induced HClO in Cancer Cells

  Hao Zhu; Jiangli Fan; Jingyun Wang; Huiying Mu; Xiaojun Peng

  Journal of the American Chemical Society, 17 Sep. 2014

  
• Highly Sensitive Naphthalene-Based Two-Photon Fluorescent Probe for in Situ Real-Time Bioimaging of Ultratrace Cyclooxygenase-2 in Living Biosystems

  Hua Zhang; Jiangli Fan; Kui Wang; Jing Li; Caixia Wang; Yamin Nie; Tao Jiang; Huiying Mu; Xiaojun Peng; Kai Jiang

  Analytical Chemistry, 16 Sep. 2014

  

Awards

• 24 Jun. 2015

  優秀修士学位論文賞(大連理工大学)

External funds: Kakenhi

• ALDH酵素を定量的に検出できる分子プローブの創製とがん幹細胞標的薬物送達法

  Grant-in-Aid for Early-Career Scientists

  Basic Section 37030:Chemical biology-related

  Kyoto University

  MU Huiying

  From 01 Apr. 2025, To 31 Mar. 2027, Granted

  蛍光プローブ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25K18145/
• Precisely activating ferroptosis by Fe(II)-triggered drug release for enhanced cancer therapy

  Grant-in-Aid for Research Activity Start-up

  0501:Physical chemistry, functional solid state chemistry, organic chemistry, polymers, organic materials, biomolecular chemistry, and related fields

  Kyoto University

  Huiying MU

  From 31 Aug. 2022, To 31 Mar. 2024, Project Closed

  fluorescence;cancer therapy;diagnosis;iron;ferroptosis;cleavage;Fe2+;fluorescent dye;pH-responsive;tumor imaging;iron(II);fluorescent probe;activatable;cyanine dye;fluorescent imaging;bond cleavage

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K20530/
• Development of Reactive Molecular Probes for the Elucidation of Metal Biodistribution in Biological Systems

  Grant-in-Aid for Scientific Research (B)

  Basic Section 33020:Synthetic organic chemistry-related

  Kyoto University

  大江 浩一

  From 01 Apr. 2025, To 31 Mar. 2028, Granted

  生体内金属センシング;分子プローブ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25K01765/

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  Energy and Hydrocarbon Chemistry, Adv.2

  D221, Spring, Graduate School of Engineering, 1.5