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Bizen, Norihisa
Graduate School of Medicine Associate Professor
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Last Updated :2026/08/21
Basic Information
Faculty
Email Address
Email Address
bizen.norihisa.5r
kyoto-u.ac.jp
Professional Memberships
Academic Degree
Academic Resume (Undergraduate School/Majors)
High School
High School
広島大学附属高等学校
Research History
- From Apr. 2026, To Present京都大学 大学院医学研究科 附属総合解剖センター 准教授
- From Oct. 2025, To Mar. 2026京都大学 大学院医学研究科 附属総合解剖センター, 助教
- From Oct. 2022, To Sep. 2025新潟大学 大学院医歯学総合研究科, 脳機能形態学分野, 医学部准教授
- From Apr. 2021, To Sep. 2025新潟大学 大学院医歯学総合研究科 脳機能形態学分野 助教 (分野名変更)
- From Feb. 2023, To Mar. 2023Department of Neuroscience, University of Connecticut Health Center, Visiting Scientist
- From Jun. 2015, To Mar. 2021Niigata University, Graduate School of Medical and Dental Sciences, 助教
- From Apr. 2014, To May 2015Niigata University, Graduate School of Medical and Dental Sciences, 博士研究員
- From Jan. 2014, To Mar. 2014Tokyo Medical and Dental University, Medical Research Institute, 特任助教
- From Apr. 2013, To Dec. 2013Tokyo Medical and Dental University, Medical Research Institute, 技術補佐員
ID,URL
J-Global ID
Researcher number
40751053
researchmap URL
list
Last Updated :2026/08/21
Research
Research Interests
Research Areas
- Life sciences, Developmental biology
- Life sciences, Neuroscience - general
- Life sciences, Neuroanatomy and physiology
- Life sciences, Anatomy
Papers
- Ddx20, DEAD-box helicase 20 is essential for maintaining microglial homeostasisYosuke Kawai; Norihisa Bizen; Kei Nishiyama; Hirohide TakebayashiExperimental Neurology, Mar. 2026, Peer-reviewed
- An inducible oligodendrocyte dysfunction triggered a pathological cascade of massive microglial activation and neurodegenerationMasataka Ise; Norihisa Bizen; Anna Simankova; Kentaro Okuyama; Shinsuke Shibata; Mari Tada; Hirohide TakebayashiNeurobiology of Disease, Nov. 2025, Peer-reviewed
- NF-κB RelA regulates temporal oligodendrocyte differentiation in the postnatal brainsKamonrapat Sompub; Norihisa Bizen; Albert S. Baldwin; Hirohide TakebayashiFrontiers in Cellular Neuroscience, 22 Jul. 2025, Peer-reviewed, Corresponding author
- Diverse functions of DEAD‐box proteins in oligodendrocyte development, differentiation, and homeostasisNorihisa Bizen; Hirohide TakebayashiJournal of Neurochemistry, 07 Oct. 2024, Peer-reviewed, Lead author, Corresponding author
- Attenuated cerebellar phenotypes in Inpp4a truncation mutants with preserved phosphatase activity.Dang Minh Tran; Nozomu Yoshioka; Norihisa Bizen; Yukiko Mori-Ochiai; Masato Yano; Shogo Yanai; Junya Hasegawa; Satoshi Miyashita; Mikio Hoshino; Junko Sasaki; Takehiko Sasaki; Hirohide TakebayashiDisease models & mechanisms, 07 Jul. 2023, Peer-reviewed
- Brain-specific glycosylation of protein tyrosine phosphatase receptor type Z (PTPRZ) marks a demyelination-associated astrocyte subtype.Kazuto Takahashi; Kenji Kanekiyo; Kanoko Sakuda; Yui Muto; Masahiro Iguchi; Nozomu Matsuda; Yuko Hashimoto; Kazuaki Kanai; Haruko Ogawa; Hajime Hirase; Akiyoshi Kakita; Norihisa Bizen; Hirohide Takebayashi; Yasushi Kawaguchi; Miwa Uzuki; Shinobu KitazumeJournal of neurochemistry, 02 Apr. 2023, Peer-reviewed
- Ddx20, an Olig2 binding factor, governs the survival of neural and oligodendrocyte progenitor cells via proper Mdm2 splicing and p53 suppression.Norihisa Bizen; Asim K Bepari; Li Zhou; Manabu Abe; Kenji Sakimura; Katsuhiko Ono; Hirohide TakebayashiCell death and differentiation, May 2022, Peer-reviewed, Lead author
- Ddx20, DEAD box helicase 20, is essential for the differentiation of oligodendrocyte and maintenance of myelin gene expression.*Anna Simankova; *Norihisa Bizen; Sei Saitoh; Shinsuke Shibata; Nobuhiko Ohno; Manabu Abe; Kenji Sakimura; Hirohide Takebayashi; (*contributed equally)Glia, 07 Jul. 2021, Peer-reviewed, Lead author
- Olig2 regulates terminal differentiation and maturation of peripheral olfactory sensory neurons.Ya-Zhou Wang; Hong Fan; Yu Ji; Kurt Reynolds; Ran Gu; Qini Gan; Takashi Yamagami; Tianyu Zhao; Salaheddin Hamad; Norihisa Bizen; Hirohide Takebayashi; YiPing Chen; Shengxi Wu; David Pleasure; Kit Lam; Chengji J ZhouCellular and molecular life sciences : CMLS, Sep. 2020, Peer-reviewed
- Glial pathology in a novel spontaneous mutant mouse of the Eif2b5 gene: a vanishing white matter disease model.Mika Terumitsu-Tsujita; Hiroki Kitaura; Ikuo Miura; Yuji Kiyama; Fumiko Goto; Yoshiko Muraki; Shiho Ominato; Norikazu Hara; Anna Simankova; Norihisa Bizen; Kazuhiro Kashiwagi; Takuhiro Ito; Yasuko Toyoshima; Akiyoshi Kakita; Toshiya Manabe; Shigeharu Wakana; Hirohide Takebayashi; Hironaka IgarashiJournal of neurochemistry, Jul. 2020, Peer-reviewed
- Diverse dystonin gene mutations cause distinct patterns of Dst isoform deficiency and phenotypic heterogeneity in Dystonia musculorum mice.Nozomu Yoshioka; Yudai Kabata; Momona Kuriyama; Norihisa Bizen; Li Zhou; Dang M Tran; Masato Yano; Atsushi Yoshiki; Tatsuo Ushiki; Thomas J Sproule; Riichiro Abe; Hirohide TakebayashiDisease models & mechanisms, 21 May 2020, Peer-reviewed
- Biallelic Variants in UBA5 Link Dysfunctional UFM1 Ubiquitin-like Modifier Pathway to Severe Infantile-Onset Encephalopathy.Mikko Muona; Ryosuke Ishimura; Anni Laari; Yoshinobu Ichimura; Tarja Linnankivi; Riikka Keski-Filppula; Riitta Herva; Heikki Rantala; Anders Paetau; Minna Pöyhönen; Miki Obata; Takefumi Uemura; Thomas Karhu; Norihisa Bizen; Hirohide Takebayashi; Shane McKee; Michael J Parker; Nadia Akawi; Jeremy McRae; Matthew E Hurles; Outi Kuismin; Mitja I Kurki; Anna-Kaisa Anttonen; Keiji Tanaka; Aarno Palotie; Satoshi Waguri; Anna-Elina Lehesjoki; Masaaki KomatsuAmerican journal of human genetics, 01 Sep. 2016, Peer-reviewed
- A Synthetic Polymer Scaffold Reveals the Self-Maintenance Strategies of Rat Glioma Stem Cells by Organization of the Advantageous Niche.Kouichi Tabu; Nozomi Muramatsu; Christian Mangani; Mei Wu; Rong Zhang; Taichi Kimura; Kazuo Terashima; Norihisa Bizen; Ryosuke Kimura; Wenqian Wang; Yoshitaka Murota; Yasuhiro Kokubu; Ikuo Nobuhisa; Tetsushi Kagawa; Issay Kitabayashi; Mark Bradley; Tetsuya TagaStem cells (Dayton, Ohio), May 2016, Peer-reviewed
- Endoplasmic Reticulum-Localized Transmembrane Protein Dpy19L1 Is Required for Neurite Outgrowth.Keisuke Watanabe; Norihisa Bizen; Noboru Sato; Hirohide TakebayashiPloS one, 2016, Peer-reviewed
- A growth-promoting signaling component cyclin D1 in neural stem cells has antiastrogliogenic function to execute self-renewal.Norihisa Bizen; Toshihiro Inoue; Takeshi Shimizu; Kouichi Tabu; Tetsushi Kagawa; Tetsuya TagaStem cells (Dayton, Ohio), Jun. 2014, Peer-reviewed, Lead author
- [Roles of GSK3beta signaling in the self-renewal of neural progenitor cells].Tetsushi Kagawa; Norihisa Bizen; Norihisa Bizen; Tetsuya TagaSeikagaku. The Journal of Japanese Biochemical Society, Feb. 2014
- Gene Regulation of Prominin-1 (CD133) in Normal and Cancerous Tissues.Kouichi Tabu; Norihisa Bizen; Tetsuya Taga; Shinya TanakaAdvances in experimental medicine and biology, 2013, Peer-reviewed
- Analysis of an alternative human CD133 promoter reveals the implication of Ras/ERK pathway in tumor stem-like hallmarks.Kouichi Tabu; Taichi Kimura; Ken Sasai; Lei Wang; Norihisa Bizen; Hiroshi Nishihara; Tetsuya Taga; Shinya TanakaMolecular cancer, 19 Feb. 2010, Peer-reviewed
Misc.
Presentations
- オリゴデンドロサイトの発達・恒常性維持機構の解明と、その破綻に起因する中枢神経系病態モデルの構築備前 典久日本薬学会第146年会 環境・衛生部会若手研究者シンポジウム, 27 Mar. 2026, Invited
- 神経幹細胞ニッチを模倣する⼈⼯ポリマーの開発備前 典久「難治疾患共同研究拠点学術集会」-幹細胞の発⽣、恒常性応答、運命遷移の分⼦基盤の新展開-, 08 Mar. 2025, Invited
- DEAD-box RNA ヘリカーゼ Ddx20 による中枢神経系の発生およびオリゴデンドロサイトの分化・恒常性維持機構.備前 典久第68回日本薬学会関東支部会 第17回日本薬学会関東支部 若手シンポジウム -難病ならびに加齢性疾患の理解と治療をめざして-, 14 Sep. 2024, Invited
- DEAD box protein Ddx20-mediated regulation of oligodendrocyte development, differentiation, and homeostasis.Norihisa Bizen17th Canadian Neuroscience Meeting CAN 2024 Japan-Canada joint parallel symposium - Myelin in neurodevelopment and neurodegeneration -, 22 May 2024, Invited
- Elucidation of the mechanisms underlying Ddx20-mediated regulation of oligodendrocyte development and homeostasis.備前 典久第66回日本神経化学会大会/第64回日本神経病理学会総会学術研 究会 合同大会 若手育成セミナー出身者によるシンポジウム -若手研究者とシニア研究者で語る日本のオリゴデンドロサイト研究-, 08 Jul. 2023, Invited
- RNAヘリカーゼDdx20によるオリゴデンドロサイトの発生・分化制御およびオリゴデンドロサイト-ニューロン間相互作用機構の解明.備前 典久第45回日本分子生物学会年会 日本生物物理学会 共催 ワークショップ グリア細胞学 / Glial Biology, グリア細胞学 -グリアから紐解く脳機能- Glial functions in brain science, 30 Nov. 2022, Invited
Books and Other Publications
- 神経幹細胞の分化制御機構：細胞外来生シグナルと細胞内在性プログラムによる分化制御備前典久; 鹿川哲史; 田賀哲也, Contributor, 再生医療シリーズ 脳神経系の発生・再生の融合的新展開 28-33ページ診断と治療社, Jan. 2015, Not refereed
- GSK3bシグナル経路による神経前駆細胞の自己複製制御鹿川哲史; 備前典久; 清水健史; 田賀哲也, Contributor, 生化学 第86巻第1号 68-71ページ日本生化学会, 2014, Not refereed
- LIF (Leukemia Inhibitory Factor)備前典久; 田賀哲也, Contributor, 臨床免疫・アレルギー科 増刊 「サイトカインのすべて」Vol.57 545-552ページ科学評論社, 2012, Not refereed
- 第2章 細胞 (その他の幹細胞など)-ものづくりから考察する幹細胞の居心地-田賀哲也; 椨康一; 備前典久, Contributor, ものづくり技術からみる再生医療-細胞研究・創薬・治療- Page 18-24シーエムシー出版, 2011, Not refereed
- アストロサイトの発生・分化鹿川哲史; 備前典久; 田賀哲也, Contributor, Clinical Neuroscience 別冊, Vol 29, No.11, Page 1239-1242中外医学社, 2011, Not refereed
Awards
- 07 Mar. 2014東京医科歯科大学難治疾患研究所優秀論文賞
- 27 Sep. 2021第１０９回日本解剖学会関東支部学術集会大会長賞
- 30 Sep. 2022第９回新潟大学学長賞 (若手教員研究奨励)
- 21 Dec. 2017次世代脳プロジェクト・冬のシンポジウム若手優秀発表賞
External funds: Kakenhi
- 合成ポリマーを用いた神経幹細胞ニッチシグナルによるミトコンドリア制御機構の解明Grant-in-Aid for Scientific Research (C)Basic Section 48010:Anatomy-relatedKyoto University備前 典久From 01 Apr. 2026, To 31 Mar. 2029, Granted神経幹細胞;自己複製;ポリマー;ミトコンドリア;ニッチ
- オリゴデンドロサイトRNA代謝調節因子による神経細胞恒常性維持機構の解明Grant-in-Aid for Scientific Research (C)Basic Section 48010:Anatomy-relatedNiigata University備前 典久From 01 Apr. 2023, To 31 Mar. 2026, Grantedオリゴデンドロサイト;神経変性;p53;Ddx20;ミエリン;ニューロン;グリア-ニューロン相互作用;相互作用;RNA;恒常性
- Mouse model of involuntary movement related to basal ganglia abnormalities and development of gene therapyGrant-in-Aid for Scientific Research (B)Basic Section 48010:Anatomy-relatedNiigata UniversityHirohide TakebayashiFrom 01 Apr. 2021, To 31 Mar. 2024, Project Closed不随意運動;ジストニア;Inpp4a;Vps13a;Dystonin (Dst);ジストニン;Dystonin;大脳基底核
- Elucidation of the molecular basis underlying p53-mediated neurodegeneration induced by oligodendrocyte dysfunctionGrant-in-Aid for Scientific Research (C)Basic Section 48010:Anatomy-relatedNiigata UniversityNorihisa BizenFrom 01 Apr. 2020, To 31 Mar. 2023, Project Closedオリゴデンドロサイト;p53;グリア;神経変性;グリア-ニューロン相互作用;グリア-ニューロン間相互作用;グリア・ニューロン相互作用
- Elucidation of the molecular mechanisms underlying the coupling between transcription and RNA metabolism during myelinationGrant-in-Aid for Young Scientists (B)Niigata UniversityNorihisa BizenFrom 01 Apr. 2017, To 31 Mar. 2020, Project Closedオリゴデンドロサイト;ミエリン;転写;RNA代謝;Olig2;RNA;スプライシング;脱髄;軸索変性;ノックアウトマウス;脱髄疾患;分化
- Elucidation of molecular mechanisms underlying a novel Olig2 binding factor-mediated oligodendrocyte differentiationGrant-in-Aid for Young Scientists (B)Niigata UniversityNorihisa BizenFrom 01 Apr. 2015, To 31 Mar. 2018, Project Closedオリゴデンドロサイト;Olig2;転写因子;p53;神経幹細胞;ノックアウトマウス;DNA損傷;細胞増殖;細胞死;ミエリン;分化促進;脱髄疾患
- Analysis on neuronal circuits responsible for involuntary movementsGrant-in-Aid for Scientific Research (B)Niigata UniversityHirohide TakebayashiFrom 01 Apr. 2015, To 31 Mar. 2018, Project Closedジストニン;三叉神経運動核;運動神経;咬筋;マクロファージ;運動ニューロン;オリゴデンドロサイト前駆細胞;増殖;ジストニア;モデルマウス;dystonin;神経科学;dystonin (Dst)
