Basic Information

Email Address

• Email Address

  kawakami.akinori.5nkyoto-u.ac.jp

Professional Memberships

• From 2023, To Present

  加齢皮膚医学研究会
• From 2022, To Present

  日本白斑学会
• From 2005, To Present

  Japanese Skin Cancer Society
• From 2004, To Present

  THE JAPANESE SOCIETY FOR INVESTIGATIVE DERMATOLOGY
• From 2003, To Present

  The Japanese Society for Plgment Cell Research
• From 2001, To Present

  JAPANESE DERMATOLOGICAL ASSOCIATION

Academic Degree

• 31 Mar. 2006

  札幌医科大学博士（医学）

Academic Resume (Graduate Schools)

• 札幌医科大学, 大学院医学研究科博士課程分子・器官制御医学専攻, 修了

Academic Resume (Undergraduate School/Majors)

• 札幌医科大学, 医学部, 卒業

Research History

• From Feb. 2022, To Present

  Kyoto University Graduate School of Medicine, Department of Dermatology, Assistant Professor
• From Sep. 2014, To Jan. 2022

  Massachusetts General Hospital/Harvard Medical School, Cutaneous Biology Research Center, Instructor
• From Sep. 2008, To Aug. 2014

  Massachusetts General Hospital/Harvard Medical School, Cutaneous Biology Research Center, Research Fellow
• From Sep. 2006, To Aug. 2008

  Dana-Farber Cancer Institute/Harvard Medical School, Research Fellow
• From Jun. 2006, To Sep. 2006

  札幌医科大学附属病院, 皮膚科学講座, 助教
• From Apr. 2006, To May 2006

  札幌医科大学附属病院, 皮膚科学講座, 診療医
• From Apr. 2003, To Mar. 2006

  札幌医科大学附属病院, 皮膚科学講座, 医員
• From Apr. 2002, To Mar. 2003

  NTT東日本札幌病院, 皮膚科, 臨床研修医
• From Apr. 2001, To Mar. 2002

  Sapporo Medical University, 皮膚科学講座, 臨床研修医

ID,URL

• ORCID ID

  0000-0001-7239-7236

• J-Global ID

  200901043806918058

researchmap URL

• https://researchmap.jp/toriisogi

Research

Research Topics, Overview of the research

• Research Topics

  「皮膚がん予防」と「人がしたいこと×健康」

• Overview of the research

  「抗老化、日内変動、がん免疫監視機構を調整することで、皮膚がんを予防する可能性」と「美容×健康」について研究しています。

Research Interests

• 皮膚がん予防
• 皮膚老化
• 欲求×健康
• 色素性疾患
• Dermatology
• Transcription factor
• Melanoma
• Melanocyte

Research Areas

• Life sciences, Dermatology
• Life sciences, Molecular biology
• Life sciences, Cell biology
• Life sciences, Immunology

Papers

• Acquired Idiopathic Generalized Anhidrosis and Frontal Fibrosing Alopecia: Possible Evidence for a Shared Autoimmune Pathogenesis

  Shota Nakayama; Akinori Kawakami; Kenji Kabashima

  International Journal of Dermatology, 19 May 2025, Peer-reviewed, Corresponding author

  Access this paper :

  
• MITF regulates IDH1, NNT, and a transcriptional program protecting melanoma from reactive oxygen species

  Elisabeth Roider; Alexandra I. T. Lakatos; Alicia M. McConnell; Poguang Wang; Alina Mueller; Akinori Kawakami; Jennifer Tsoi; Botond L. Szabolcs; Anna A. Ascsillán; Yusuke Suita; Vivien Igras; Jennifer A. Lo; Jennifer J. Hsiao; Rebecca Lapides; Dorottya M. P. Pál; Anna S. Lengyel; Alexander Navarini; Arimichi Okazaki; Othon Iliopoulos; István Németh; Thomas G. Graeber; Leonard Zon; Roger W. Giese; Lajos V. Kemeny; David E. Fisher

  Scientific Reports, 14 Sep. 2024, Peer-reviewed

  
• Salvage of ribose from uridine or RNA supports glycolysis in nutrient-limited conditions

  Owen S. Skinner; Joan Blanco-Fernández; Russell P. Goodman; Akinori Kawakami; Hongying Shen; Lajos V. Kemény; Lena Joesch-Cohen; Matthew G. Rees; Jennifer A. Roth; David E. Fisher; Vamsi K. Mootha; Alexis A. Jourdain

  Nature Metabolism, 17 May 2023, Peer-reviewed

  
• A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy

  Zaizhou Liu; Kaige Chen; Jun Dai; Peng Xu; Wei Sun; Wanlin Liu; Zhixin Zhao; Steven P. Bennett; Peifeng Li; Tiancheng Ma; Yuqi Lin; Akinori Kawakami; Jing Yu; Fei Wang; Chunxi Wang; Miao Li; Peter Chase; Peter Hodder; Timothy P. Spicer; Louis Scampavia; Chunyang Cao; Lifeng Pan; Jiajia Dong; Yong Chen; Biao Yu; Min Guo; Pengfei Fang; David E. Fisher; Jing Wang

  Cell Research, 02 Jan. 2023, Peer-reviewed

  
• CYP27A1-dependent anti-melanoma activity of limonoid natural products targets mitochondrial metabolism

  Hyelim Cho; Qiong Shen; Lydia H. Zhang; Mikiko Okumura; Akinori Kawakami; Jessi Ambrose; Frederic Sigoillot; Howard R. Miller; Scott Gleim; Amanda Cobos-Correa; Ying Wang; Philippe Piechon; Guglielmo Roma; Fabian Eggimann; Charles Moore; Peter Aspesi; Felipa A. Mapa; Heather Burks; Nathan T. Ross; Philipp Krastel; Marc Hild; Thomas J. Maimone; David E. Fisher; Daniel K. Nomura; John A. Tallarico; Stephen M. Canham; Jeremy L. Jenkins; William C. Forrester

  Cell Chemical Biology, Oct. 2021, Peer-reviewed

  
• NNT mediates redox-dependent pigmentation via a UVB- and MITF-independent mechanism

  Jennifer Allouche; Inbal Rachmin; Kaustubh Adhikari; Luba M. Pardo; Ju Hee Lee; Alicia M. McConnell; Shinichiro Kato; Shaohua Fan; Akinori Kawakami; Yusuke Suita; Kazumasa Wakamatsu; Vivien Igras; Jianming Zhang; Paula P. Navarro; Camila Makhlouta Lugo; Haley R. Noonan; Kathleen A. Christie; Kaspar Itin; Nisma Mujahid; Jennifer A. Lo; Chong Hyun Won; Conor L. Evans; Qing Yu Weng; Hequn Wang; Sam Osseiran; Alyssa Lovas; István Németh; Antonio Cozzio; Alexander A. Navarini; Jennifer J. Hsiao; Nhu Nguyen; Lajos V. Kemény; Othon Iliopoulos; Carola Berking; Thomas Ruzicka; Rolando Gonzalez-José; Maria-Cátira Bortolini; Samuel Canizales-Quinteros; Victor Acuna-Alonso; Carla Gallo; Giovanni Poletti; Gabriel Bedoya; Francisco Rothhammer; Shosuke Ito; Maria Vittoria Schiaffino; Luke H. Chao; Benjamin P. Kleinstiver; Sarah Tishkoff; Leonard I. Zon; Tamar Nijsten; Andrés Ruiz-Linares; David E. Fisher; Elisabeth Roider

  Cell, Aug. 2021, Peer-reviewed

  
• Elucidation of Melanogenesis Cascade for Identifying Pathophysiology and Therapeutic Approach of Pigmentary Disorders and Melanoma.

  Tokimasa Hida; Takafumi Kamiya; Akinori Kawakami; Jiro Ogino; Hitoshi Sohma; Hisashi Uhara; Kowichi Jimbow

  International Journal of Molecular Sciences, 25 Aug. 2020, Peer-reviewed, Invited

  
• Local genomic features predict the distinct and overlapping binding patterns of the bHLH‐Zip family oncoproteins MITF and MYC‐MAX

  Miroslav Hejna; Wooyoung M. Moon; Jeffrey Cheng; Akinori Kawakami; David E. Fisher; Jun S. Song

  Pigment Cell & Melanoma Research, Jul. 2019, Peer-reviewed

  
• The lncRNA RMEL3 protects immortalized cells from serum withdrawal‐induced growth arrest and promotes melanoma cell proliferation and tumor growth

  Cibele Cardoso; Rodolfo B. Serafim; Akinori Kawakami; Cristiano Gonçalves Pereira; Jason Roszik; Valeria Valente; Vinicius L. Vazquez; David E. Fisher; Enilza M. Espreafico

  Pigment Cell & Melanoma Research, Mar. 2019, Peer-reviewed

  
• Tfe3 and Tfeb Transcriptionally Regulate Peroxisome Proliferator-Activated Receptor gamma 2 Expression in Adipocytes and Mediate Adiponectin and Glucose Levels in Mice

  Nunciada Salma; Jun S. Song; Akinori Kawakami; Suprabha P. Devi; Mehdi Khaled; Jose M. Cacicedo; David E. Fisher

  Molecular and Cellular Biology, Aug. 2017, Peer-reviewed

  
• The master role of microphthalmia-associated transcription factor in melanocyte and melanoma biology

  Akinori Kawakami; David E. Fisher

  Laboratory Investigation, Jun. 2017, Peer-reviewed, Invited

  
• A Novel Role for Microphthalmia-Associated Transcription Factor-Regulated Pigment Epithelium-Derived Factor during Melanoma Progression

  Soheil S. Dadras; Richard J. Lin; Gita Razavi; Akinori Kawakami; Jinyan Du; Erez Feige; Daniel A. Milner; Massimo F. Loda; Scott R. Granter; Michael Detmar; Hans R. Widlund; Martin A. Horstmann; David E. Fisher

  American Journal of Pathology, Jan. 2015, Peer-reviewed

  
• Regulation of MITF stability by the USP13 deubiquitinase

  Xiansi Zhao; Brian Fiske; Akinori Kawakami; Juying Li; David E. Fisher

  Nature Communications, Aug. 2011, Peer-reviewed

  
• Rab7 is a critical mediator in vesicular transport of tyrosinase-related protein 1 in melanocytes

  Tokimasa Hida; Hitoshi Sohma; Yasuo Kokai; Akinori Kawakami; Kuninori Hirosaki; Masae Okura; Noriko Tosa; Toshiharu Yamashita; Kowichi Jimbow

  Journal of Dermatology, May 2011, Peer-reviewed

  
• Key discoveries in melanocyte development

  Kawakami A; Fisher DE

  Journal of Invetigative Dermatology, 2011, Peer-reviewed, Invited

  
• Spontaneous regression of bowenoid papulosis in a patient with acquired immunodeficiency syndrome after an increase in peripheral CD4+T lymphocytes

  Akinori Kawakami; Kenji Saga; Ichiro Ono; Tokimasa Hida; Kowichi Jimbow; Toshiharu Yamashita

  International Journal of Dermatology, Feb. 2009, Peer-reviewed, Lead author

  
• Rab7 regulates maturation of melanosomal matrix protein gp100/Pmel17/Silv

  Akinori Kawakami; Fumio Sakane; Shin-Ichi Imai; Satoshi Yasuda; Masahiro Kai; Hideo Kanoh; Hai-Ying Jin; Kuninori Hirosaki; Toshiharu Yamashita; David E. Fisher; Kowichi Jimbow

  Journal of Investigative Dermatology, Jan. 2008, Peer-reviewed, Lead author

  
• Fulminant bowel-associated dermatosis-arthritis syndrome that clinically showed necrotizing fasciitis-like severe skin and systemic manifestations

  A Kawakami; K Saga; T Hida; K Jimbow; H Takahashi

  Journal of the European Acacdemy of Dermatology and Venereology, Jul. 2006, Peer-reviewed, Lead author

  
• Dextromethorphan induces multifocal fixed drug eruption

  A Kawakami; H Nakayama; Y Yamada; K Hirosaki; T Yamashita; S Kondo; K Jimbow

  International Journal of Dermatology, Jun. 2003, Peer-reviewed, Lead author

  

Presentations

• MITF and neural transcription factors compete to decide the fate of Schwann cell precursors

  2024 SID Annual Meeting, 17 May 2024, Society for Investigative Dermatology

  
• A repressive activity of MITF plays a key role in melanocyte development

  31st KSID Annual Meeting, 23 Mar. 2024, Korean Society for Investigative Dermatology

  
• MITF represses neural genes to specify melanocytes

  The 25th International Pigment Cell Conference, 01 Jun. 2023, European Society for Pigment Cell Research, Invited

  
• A mutual repression between MITF and neural transcription factors specifies the fate of Schwann cell precursors

  The 1st International Societies for Investigative Dermatology, 13 May 2023, Japanese Society for Investigative Dermatology

  
• MITF specifies melanocytes through repressing neural genes

  The 47th Annual Meeting of the Japanese Society for Investigative Dermatology, 02 Dec. 2022, Japanese Society for Investigative Dermatology

  
• MITF specifies melanocytes through repressing neural genes

  Akinori Kawakami

  第31回日本色素細胞学会学術大会, 12 Nov. 2022, 日本色素細胞学会

  

Books and Other Publications

• ハーバード医科大学院研究留学の教科書

  西本 祥仁, Contributor

  日本医事新報社, Jan. 2026

  Find Kyoto University's collection of books :

  
• 研究留学のすゝめ! : 渡航前の準備から留学後のキャリアまで

  海外日本人研究者ネットワーク; カガクシャ・ネット, Contributor

  羊土社, Dec. 2016

  Find Kyoto University's collection of books :

  

Academic, Social Contribution

Committee Memberships

• From 2025, To Present

  理事, 日本色素細胞学会
• From 2022, To Present

  評議員, 日本研究皮膚科学会
• From 2024, To 2025

  第33回日本Cell Death学会学術集会 事務局長, 日本Cell Death学会
• From 2021, To 2022

  Board Member, JB Line Inc.
• From 2016, To 2021

  理事, 一般社団法人 海外日本人研究者ネットワーク（UJA）

Academic Contribution

• The 6th Japan-US Science Forum in Bostonの企画・運営

  Planning, management, etc.

  日本学術振興会 ワシントン研究連絡センター, From 2021, To 2021

  
• The 5th Japan-US Science Forum in Bostonの企画・運営

  Planning, management, etc.

  日本学術振興会 ワシントン研究連絡センター, From 2020, To 2020

  
• The 4th Japan-US Science Forum in Bostonの企画・運営

  Planning, management, etc.

  日本学術振興会 ワシントン研究連絡センター, From 2019, To 2019

  
• The 3rd Japan-US Science Forum in Bostonの企画・運営

  Planning, management, etc.

  日本学術振興会 ワシントン研究連絡センター, From 2018, To 2018

  
• The 2nd Japan-US Science Forum in Bostonの企画・運営

  Planning, management, etc.

  日本学術振興会 ワシントン研究連絡センター, From 2017, To 2017

  
• The 1st Japan-US Science Forum in Bostonの企画・運営

  Planning, management, etc.

  日本学術振興会 ワシントン研究連絡センター, From 2016, To 2016

  

Social Contribution

• 北海道・マサチューセッツ州姉妹提携事業「マサチューセッツ通信」の企画・編集

  Chief editor, Edit, Planner

  北海道庁, マサチューセッツ通信, From 2020, To 2025

  
• 一般社団法人 海外日本人研究者ネットワーク（UJA）広報誌「UJA Gazette」の企画・編集

  Chief editor, Edit, Planner

  一般社団法人 海外日本人研究者ネットワーク（UJA）, From 2020, To 2021

  
• ボストン日本祭り 戦略チーム リーダー

  Planner, Logistic support

  ボストン, From 2018, To 2019