Uesugi, Miwa(KYOTO UNIVERSITY HOSPITAL) | Activity Database on Education and Research, Kyoto University

Uesugi, Miwa

KYOTO UNIVERSITY HOSPITAL

Last Updated :2025/06/20

Last Updated :2025/06/20

Research Topics
Translational research of biomarkers in grafted liver injury
Overview of the research
肝臓移植治療において、移植された肝臓に対する拒絶反応（免疫反応）を抑えるために使用する免疫抑制剤の個人差について、遺伝子レベルで研究してきました。拒絶反応や感染による胆道の炎症などの合併症は、移植後の肝障害を引き起こします。現在は、合併症の正確な診断や予防のために用いることができる、肝障害の要因を反映する新たな指標（バイオマーカー）の探索を行っています。

Successful Telaprevir Treatment in Combination of Cyclosporine against Recurrence of Hepatitis C in the Japanese Liver Transplant Patients
Mio Kikuchi; Yuki Okuda; Yoshihide Ueda; Yuki Nishioka; Miwa Uesugi; Emina Hashimoto; Tamotsu Takahashi; Tomoki Kawai; Sachiyo Hashi; Haruka Shinke; Tomohiro Omura; Atsushi Yonezawa; Takashi Ito; Yasuhiro Fujimoto; Toshimi Kaido; Tsutomu Chiba; Shinji Uemoto; Kazuo Matsubara; Satohiro Masuda
BIOLOGICAL & PHARMACEUTICAL BULLETIN, Mar. 2014, Peer-reviewed

Influence of Cytochrome P450 (CYP) 3A4*1G Polymorphism on the Pharmacokinetics of Tacrolimus, Probability of Acute Cellular Rejection, and mRNA Expression Level of CYP3A5 Rather than CYP3A4 in Living-Donor Liver Transplant Patients
Miwa Uesugi; Mio Hosokawa; Haruka Shinke; Emina Hashimoto; Tamotsu Takahashi; Tomoki Kawai; Kazuo Matsubara; Kohei Ogawa; Yasuhiro Fujimoto; Shinya Okamoto; Toshimi Kaido; Shinji Uemoto; Satohiro Masuda
BIOLOGICAL & PHARMACEUTICAL BULLETIN, Nov. 2013, Peer-reviewed

Impact of MDR1 and CYP3A5 on the oral clearance of tacrolimus and tacrolimus-related renal dysfunction in adult living-donor liver transplant patients
Masahide Fukudo; Ikuko Yano; Atsushi Yoshimura; Satohiro Masuda; Miwa Uesugi; Keiko Hosohata; Toshiya Katsura; Yasuhiro Ogura; Fumitaka Oike; Yasutsugu Takada; Shinji Uemoto; Ken-ichi Inui
PHARMACOGENETICS AND GENOMICS, May 2008, Peer-reviewed

Population pharmacokinetic and pharmacogenomic analysis of tacrolimus in pediatric living-donor liver transplant recipients
Masahide Fukudo; Ikuko Yano; Satohiro Masuda; Maki Goto; Miwa Uesugi; Toshiya Katsura; Yasuhiro Ogura; Fumitaka Oike; Yasutsugu Takada; Hiroto Egawa; Shinji Uemoto; Ken-ichi Inui
CLINICAL PHARMACOLOGY & THERAPEUTICS, Oct. 2006, Peer-reviewed

Effect of intestinal CYP3A5 on postoperative tacrolimus trough levels in living-donor liver transplant recipients
Miwa Uesugi; Satohiro Masuda; Toshiya Katsura; Fumitaka Oike; Yasutsugu Takada; Ken-ichi Inui
PHARMACOGENETICS AND GENOMICS, Feb. 2006, Peer-reviewed

Intestinal MDR1/ABCB1 level at surgery as a risk factor of acute cellular rejection in living-donor liver transplant patients
S Masuda; M Goto; S Fukatsu; M Uesugi; Y Ogura; F Oike; T Kiuchi; Y Takada; K Tanaka; KI Inui
CLINICAL PHARMACOLOGY & THERAPEUTICS, Jan. 2006, Peer-reviewed

Association between biliary concentration of 13-O-demethylated tacrolimus and clinical course in liver transplant patients
Uesugi M
12th International Congress of Therapeutic Drug Monitoring and Clinical Toxicology, 06 Oct. 2011