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Hiiragi, Takashi

Graduate School of Medicine, Medicine Professor

Hiiragi, Takashi
list
    Last Updated :2025/07/19

    Basic Information

    Faculty

    • Faculty of Medicine

    Academic Degree

    • 博士(医学)(京都大学)

    Academic Resume (Graduate Schools)

    • 京都大学, 大学院医学研究科博士課程医学専攻, 研究指導認定退学
    • 京都大学, 大学院医学研究科博士課程医学専攻, 修了

    Research History

    • From Jan. 2023, To Present
      Kyoto University, Graduate School of Medicine Department of Developmental Biology, Professor
    • From 2021, To Present
      Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), Senior Group Leader
    • From 2019, To Present
      Kyoto University Institute for Advanced Study, Institute for the Advanced Study of Human Biology (ASHBi), Distinguished Visiting Professor
    • From 2011, To 2021
      European Molecular Biology Laboratory (EMBL), Developmental Biology Unit, Group Leader
    • From 2018, To 2019
      University of Cambridge, Charles Darwin Professor of Animal Embryology
    • From 2008, To 2013
      Kyoto University, Institute for Integrated Cell-Material Sciences (iCeMS), Program-specific center professor
    • From Apr. 2007, To 2011
      Max-Planck Institute for Molecular Biomedicine, Mammalian Development Laboratory, Independent group leader
    • From Feb. 2002, To Mar. 2007
      Max-Planck Institute of Immunobiology, Department of Developmental Biology, Junior group leader
    • From Jul. 2000, To Feb. 2002
      Max-Planck Institute of Immunobiology, Department of Developmental Biology, Postdoctoral fellow
    • From Apr. 2000, To Jun. 2000
      Kyoto University, Graduate School of Medicine Congenital Anomaly Research Center, Lecturer
    • From Apr. 1999, To Mar. 2000
      Kyoto University, Faculty of Medicine, medical intern
    • From May 1993, To Mar. 1995
      Kobe City Medical Center General Hospital, medical intern

    ID,URL

    researchmap URL

    list
      Last Updated :2025/07/19

      Research

      Research Topics, Overview of the research

      • Research Topics

        - Principles and molecular mechanism of early mammalian embryo patterning

        - A systems-level understanding of early mouse development
      • Overview of the research

        The ultimate goal of the research in our laboratory is the understanding of totipotency: what defines totipotency and what makes cell totipotent. Germ-line cells, oocyte and sperm, are highly differentiated but nevertheless able to regain totipotency by forming a zygote, thereby initiating embryonic development in the next generation. A prerequisite for understanding totipotency is the knowledge of developmental mechanisms during transition from oocyte to embryo and early embryogenesis. Our current research thus focuses on understanding the principles underlying early mammalian development.

      Research Areas

      • Life sciences, Developmental biology

      Papers

      • Boundary-guided cell alignment drives mouse epiblast maturation
        Takafumi Ichikawa; Pamela C. Guruciaga; Shuchang Hu; Steffen Plunder; Mei Makino; Marina Hamaji; Anniek Stokkermans; Shinjiro Yoshida; Anna Erzberger; Takashi Hiiragi
        01 May 2025
      • Coupling of cell shape, matrix and tissue dynamics ensures embryonic patterning robustness
        Prachiti Moghe; Roman Belousov; Takafumi Ichikawa; Chizuru Iwatani; Tomoyuki Tsukiyama; Anna Erzberger; Takashi Hiiragi
        Nature Cell Biology, 18 Feb. 2025
      • Boundary geometry controls topological defect transitions that determine lumen nucleation in embryonic development
        Pamela C. Guruciaga; Takafumi Ichikawa; Takashi Hiiragi; Anna Erzberger
        arXiv, 13 Mar. 2024
      • Poissonian Cellular Potts Models Reveal Nonequilibrium Kinetics of Cell Sorting
        R. Belousov; S. Savino; P. Moghe; T. Hiiragi; L. Rondoni; A. Erzberger
        Physical Review Letters, 10 Jun. 2024
      • Epigenetic mechanisms in early mammalian development
        Solter, D.; Hiiragi, T.; Evsikov, A.V.; Moyer, J.; De Vries, W.N.; Peaston, A.E.; Knowles, B.
        Cold Spring Harbor Symposia on Quantitative Biology, 2004
      • Pseudoxanthoma elasticum associated with unstable angina and Leriche syndrome: A case report
        Hiiragi, T.; Yoshikawa, J.; Okura, H.; Honda, Y.; Akasaka, T.
        Journal of Cardiology, 1995
      • Competence for neural crest induction is controlled by hydrostatic pressure through Yap
        Delan N. Alasaadi; Lucas Alvizi; Jonas Hartmann; Namid Stillman; Prachiti Moghe; Takashi Hiiragi; Roberto Mayor
        Nature Cell Biology, Apr. 2024
      • Embryo-uterine interaction coordinates mouse embryogenesis during implantation
        Bondarenko, V; Nikolaev, M; Kromm, D; Belousov, R; Wolny, A; Blotenburg, M; Zeller, P; Rezakhani, S; Hugger, J; Uhlmann, V; Hufnagel, L; Kreshuk, A; Ellenberg, J; van Oudenaarden, A; Erzberger; A. Lutolf; M; Hiiragi, T
        EMBO J, 31 Jul. 2023
      • Muscular hydraulics drive larva-polyp morphogenesis
        Anniek Stokkermans; Aditi Chakrabarti; Kaushikaram Subramanian; Ling Wang; Sifan Yin; Prachiti Moghe; Petrus Steenbergen; Gregor Mönke; Takashi Hiiragi; Robert Prevedel; L. Mahadevan; Aissam Ikmi
        Current Biology, 07 Nov. 2022
      • Apical-driven cell sorting optimised for tissue geometry ensures robust patterning
        Prachiti Moghe; Roman Belousov; Takafumi Ichikawa; Chizuru Iwatani; Tomoyuki Tsukiyama; François Graner; Anna Erzberger; Takashi Hiiragi
        17 May 2023
      • Temporal variability and cell mechanics control robustness in mammalian embryogenesis
        Dimitri Fabrèges; Bernat Corominas Murtra; Prachiti Moghe; Alison Kickuth; Takafumi Ichikawa; Chizuru Iwatani; Tomoyuki Tsukiyama; Nathalie Daniel; Julie Gering; Anniek Stokkermans; Adrian Wolny; Anna Kreshuk; Véronique Duranthon; Virginie Uhlmann; Edouard Hannezo; Takashi Hiiragi
        24 Jan. 2023
      • Major construction entails major demolition.
        Ekaterina Korotkevich; Takashi Hiiragi
        Developmental cell, 06 Jun. 2022
      • An ex vivo system to study cellular dynamics underlying mouse peri-implantation development.
        Takafumi Ichikawa; Hui Ting Zhang; Laura Panavaite; Anna Erzberger; Dimitri Fabrèges; Rene Snajder; Adrian Wolny; Ekaterina Korotkevich; Nobuko Tsuchida-Straeten; Lars Hufnagel; Anna Kreshuk; Takashi Hiiragi
        Developmental cell, 07 Feb. 2022
      • ECM-integrin signalling instructs cellular position sensing to pattern the early mouse embryo.
        Esther Jeong Yoon Kim; Lydia Sorokin; Takashi Hiiragi
        Development (Cambridge, England), 01 Jan. 2022
      • 20 years of Developmental Cell: Looking forward.
        Takashi Hiiragi; Amy S Gladfelter; Irene Miguel-Aliaga; Hilary A Coller; On Sun Lau; Heidi M McBride; Kazuhiro Aoki; Andreas Linkermann; Stefano Santaguida; Geoffrey Wasteneys; Nicolas C Rivron; Marta N Shahbazi; Miki Ebisuya; Madeline A Lancaster
        Developmental cell, 06 Dec. 2021
      • Cell fate coordinates mechano-osmotic forces in intestinal crypt formation.
        Qiutan Yang; Shi-Lei Xue; Chii Jou Chan; Markus Rempfler; Dario Vischi; Francisca Maurer-Gutierrez; Takashi Hiiragi; Edouard Hannezo; Prisca Liberali
        Nature cell biology, Jul. 2021
      • Inferring cell junction tension and pressure from cell geometry.
        Chloé Roffay; Chii J Chan; Boris Guirao; Takashi Hiiragi; François Graner
        Development (Cambridge, England), 12 Mar. 2021
      • Integration of luminal pressure and signalling in tissue self-organization.
        Chii J Chan; Takashi Hiiragi
        Development (Cambridge, England), 02 Mar. 2020
      • Lumen Expansion Facilitates Epiblast-Primitive Endoderm Fate Specification during Mouse Blastocyst Formation.
        Allyson Quinn Ryan; Chii Jou Chan; François Graner; Takashi Hiiragi
        Developmental cell, 16 Dec. 2019
      • A Tug-of-War between Cell Shape and Polarity Controls Division Orientation to Ensure Robust Patterning in the Mouse Blastocyst.
        Ritsuya Niwayama; Prachiti Moghe; Yan-Jun Liu; Dimitri Fabrèges; Frank Buchholz; Matthieu Piel; Takashi Hiiragi
        Developmental cell, 02 Dec. 2019
      • Hydraulic control of mammalian embryo size and cell fate.
        Chii Jou Chan; Maria Costanzo; Teresa Ruiz-Herrero; Gregor Mönke; Ryan J Petrie; Martin Bergert; Alba Diz-Muñoz; L Mahadevan; Takashi Hiiragi
        Nature, Jul. 2019
      • Symmetry Breaking in the Mammalian Embryo.
        Hui Ting Zhang; Takashi Hiiragi
        Annual review of cell and developmental biology, 06 Oct. 2018
      • Dual-spindle formation in zygotes keeps parental genomes apart in early mammalian embryos.
        Judith Reichmann; Bianca Nijmeijer; M Julius Hossain; Manuel Eguren; Isabell Schneider; Antonio Z Politi; M Julia Roberti; Lars Hufnagel; Takashi Hiiragi; Jan Ellenberg
        Science (New York, N.Y.), 13 Jul. 2018
      • Coordination of Cell Polarity, Mechanics and Fate in Tissue Self-organization.
        Esther Jeong Yoon Kim; Ekaterina Korotkevich; Takashi Hiiragi
        Trends in cell biology, Jul. 2018
      • Keeping in Touch to Differentiate.
        Chii J Chan; Takashi Hiiragi
        Developmental cell, 23 Oct. 2017
      • Coordination of Morphogenesis and Cell-Fate Specification in Development.
        Chii J Chan; Carl-Philipp Heisenberg; Takashi Hiiragi
        Current biology : CB, 25 Sep. 2017
      • Corrigendum: Pulsatile cell-autonomous contractility drives compaction in the mouse embryo.
        Jean-Léon Maître; Ritsuya Niwayama; Hervé Turlier; François Nédélec; Takashi Hiiragi
        Nature cell biology, 28 Jul. 2017
      • Inferring cellular forces from image stacks.
        Jim H Veldhuis; Ahmad Ehsandar; Jean-Léon Maître; Takashi Hiiragi; Simon Cox; G Wayne Brodland
        Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 19 May 2017
      • The Apical Domain Is Required and Sufficient for the First Lineage Segregation in the Mouse Embryo.
        Ekaterina Korotkevich; Ritsuya Niwayama; Aurélien Courtois; Stefanie Friese; Nicolas Berger; Frank Buchholz; Takashi Hiiragi
        Developmental cell, 06 Feb. 2017
      • Asymmetric division of contractile domains couples cell positioning and fate specification.
        Jean-Léon Maître; Hervé Turlier; Rukshala Illukkumbura; Björn Eismann; Ritsuya Niwayama; François Nédélec; Takashi Hiiragi
        Nature, 18 Aug. 2016
      • Inverted light-sheet microscope for imaging mouse pre-implantation development.
        Petr Strnad; Stefan Gunther; Judith Reichmann; Uros Krzic; Balint Balazs; Gustavo de Medeiros; Nils Norlin; Takashi Hiiragi; Lars Hufnagel; Jan Ellenberg
        Nature methods, Feb. 2016
      • Confocal multiview light-sheet microscopy.
        Gustavo de Medeiros; Nils Norlin; Stefan Gunther; Marvin Albert; Laura Panavaite; Ulla-Maj Fiuza; Francesca Peri; Takashi Hiiragi; Uros Krzic; Lars Hufnagel
        Nature communications, 25 Nov. 2015
      • Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages.
        Jens-Erik Dietrich; Laura Panavaite; Stefan Gunther; Sebastian Wennekamp; Anna C Groner; Anton Pigge; Stefanie Salvenmoser; Didier Trono; Lars Hufnagel; Takashi Hiiragi
        EMBO reports, Aug. 2015
      • Pulsatile cell-autonomous contractility drives compaction in the mouse embryo.
        Jean-Léon Maître; Ritsuya Niwayama; Hervé Turlier; François Nédélec; Takashi Hiiragi
        Nature cell biology, Jul. 2015
      • Cell-to-cell expression variability followed by signal reinforcement progressively segregates early mouse lineages.
        Yusuke Ohnishi; Wolfgang Huber; Akiko Tsumura; Minjung Kang; Panagiotis Xenopoulos; Kazuki Kurimoto; Andrzej K Oleś; Marcos J Araúzo-Bravo; Mitinori Saitou; Anna-Katerina Hadjantonakis; Takashi Hiiragi
        Nature cell biology, Jan. 2014
      • A self-organization framework for symmetry breaking in the mammalian embryo.
        Sebastian Wennekamp; Sven Mesecke; François Nédélec; Takashi Hiiragi
        Nature reviews. Molecular cell biology, Jul. 2013
      • The transition from meiotic to mitotic spindle assembly is gradual during early mammalian development.
        Aurélien Courtois; Melina Schuh; Jan Ellenberg; Takashi Hiiragi
        The Journal of cell biology, 06 Aug. 2012
      • The Krüppel-associated box repressor domain can induce reversible heterochromatization of a mouse locus in vivo.
        Anna C Groner; Patrick Tschopp; Ludivine Challet; Jens-Erik Dietrich; Sonia Verp; Sandra Offner; Isabelle Barde; Ivan Rodriguez; Takashi Hiiragi; Didier Trono
        The Journal of biological chemistry, 20 Jul. 2012
      • Bmi1 facilitates primitive endoderm formation by stabilizing Gata6 during early mouse development.
        Fabrice Lavial; Sylvain Bessonnard; Yusuke Ohnishi; Akiko Tsumura; Anil Chandrashekran; Mark A Fenwick; Rute A Tomaz; Hiroyuki Hosokawa; Toshinori Nakayama; Ian Chambers; Takashi Hiiragi; Claire Chazaud; Véronique Azuara
        Genes & development, 01 Jul. 2012
      • Stochastic processes in the development of pluripotency in vivo.
        Sebastian Wennekamp; Takashi Hiiragi
        Biotechnology journal, Jun. 2012
      • Gradual meiosis-to-mitosis transition in the early mouse embryo.
        Aurélien Courtois; Takashi Hiiragi
        Results and problems in cell differentiation, 2012
      • [Unique principles in early mammalian development].
        Takashi Hiiragi
        Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, May 2008
      • Computer simulation of emerging asymmetry in the mouse blastocyst.
        Hisao Honda; Nami Motosugi; Tatsuzo Nagai; Masaharu Tanemura; Takashi Hiiragi
        Development (Cambridge, England), Apr. 2008
      • Dynamic rearrangement of surface proteins is essential for cytokinesis.
        Tobias Bauer; Nami Motosugi; Koichi Miura; Hisataka Sabe; Takashi Hiiragi
        Genesis (New York, N.Y. : 2000), Mar. 2008
      • Stochastic processes during mouse blastocyst patterning.
        Jens Erik Dietrich; Takashi Hiiragi
        Cells, tissues, organs, 2008
      • Hypomethylation of paternal DNA in the late mouse zygote is not essential for development.
        Zbigniew Polanski; Nami Motosugi; Chizuko Tsurumi; Takashi Hiiragi; Steffen Hoffmann
        The International journal of developmental biology, 2008
      • Stochastic patterning in the mouse pre-implantation embryo.
        Jens-Erik Dietrich; Takashi Hiiragi
        Development (Cambridge, England), Dec. 2007
      • Embryology: does prepatterning occur in the mouse egg?
        Takashi Hiiragi; Sophie Louvet-Vallée; Davor Solter; Bernard Maro
        Nature, 13 Jul. 2006
      • Space asymmetry directs preferential sperm entry in the absence of polarity in the mouse oocyte.
        Nami Motosugi; Jens-Erik Dietrich; Zbigniew Polanski; Davor Solter; Takashi Hiiragi
        PLoS biology, May 2006
      • Fatal flaws in the case for prepatterning in the mouse egg.
        Takashi Hiiragi; Davor Solter
        Reproductive biomedicine online, Feb. 2006
      • Where do we stand now? Mouse early embryo patterning meeting in Freiburg, Germany (2005).
        Takashi Hiiragi; Vernadeth B Alarcon; Toshihiko Fujimori; Sophie Louvet-Vallee; Marek Maleszewski; Yusuke Marikawa; Bernard Maro; Davor Solter
        The International journal of developmental biology, 2006
      • Mechanism of first cleavage specification in the mouse egg: is our body plan set at day 0?
        Takashi Hiiragi; Davor Solter
        Cell cycle (Georgetown, Tex.), May 2005
      • Polarity of the mouse embryo is established at blastocyst and is not prepatterned.
        Nami Motosugi; Tobias Bauer; Zbigniew Polanski; Davor Solter; Takashi Hiiragi
        Genes & development, 01 May 2005
      • Reprogramming is essential in nuclear transfer.
        Takashi Hiiragi; Davor Solter
        Molecular reproduction and development, Apr. 2005
      • First cleavage plane of the mouse egg is not predetermined but defined by the topology of the two apposing pronuclei.
        Takashi Hiiragi; Davor Solter
        Nature, 15 Jul. 2004
      • Role of transglutaminase 1 in stabilisation of intercellular junctions of the vascular endothelium.
        Werner Baumgartner; Nikola Golenhofen; Agnes Weth; Takashi Hiiragi; Rob Saint; Martin Griffin; Detlev Drenckhahn
        Histochemistry and cell biology, Jul. 2004
      • Transglutaminase type 1 and its cross-linking activity are concentrated at adherens junctions in simple epithelial cells
        Hiiragi, T.; Sasaki, H.; Nagafuchi, A.; Sabe, H.; Shen, S.C.; Matsuki, M.; Yamanishi, K.; Tsukita, S.
        Journal of Biological Chemistry, 26 Nov. 1999
      • Claudin-1 and -2: Novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin
        Furuse, M.; Fujita, K.; Hiiragi, T.; Fujimoto, K.; Tsukita, S.
        Journal of Cell Biology, 29 Jun. 1998

      Misc.

      • 細胞間の遺伝子発現のばらつきが及ぼすマウス胚の細胞分化
        大西悠亮; HUBER Wolfgang; 津村明子; KANG Minjung; XENOPOULOS Panagiotis; 栗本一基; OLES Andrzej; ARAUZO-BRAVO Marcos J.; 斎藤通紀; HADJANTONAKIS Anna-Katerina; 柊卓志
        日本分子生物学会年会プログラム・要旨集(Web), 2013
      • マウス初期胚軸形成のダイナミクス
        柊卓志; 柊卓志; 柊卓志
        生化学, 2009
      • マウス初期発生プログラムの基本原理
        柊卓志
        Journal of Mammalian Ova Research, 2009
      • 哺乳類パターン形成の基本原理
        柊卓志; 柊卓志
        蛋白質 核酸 酵素, 2008
      • マウス卵における成熟分裂過程が個体発生能に及ぼす影響
        本杉奈美; POLANSKI Zbigniew; 柊卓志; 木村穣
        生化学, 2007
      • マウス卵における成熟分裂過程が個体発生能に及ぼす影響
        本杉奈美; POLANSKI Zbigniew; 柊卓志; 木村穣
        Journal of Mammalian Ova Research, 2007
      • 3D細胞多面体モデルをほ乳類初期はい(はい盤胞)形成に適用する
        本多久夫; 柊卓志; 長井達三; 種村正美
        形の科学会誌, 2005
      • 3D多面体細胞モデルによるはい盤胞形成シミュレーション
        本多久夫; 柊卓志; 長井達三; 種村正美
        日本発生生物学会大会発表要旨集, 2005
      • マウス未受精卵に極性はあるのか?
        本杉奈美; DIETRICH Jens-Erik; POLANSKI Zbigniew; SOLTER Davor; 柊卓志
        日本畜産学会大会講演要旨, 2005
      • 細胞間接着部位(AJ)におけるTransglutaminaseの解析
        柊卓志; 山西清文; 月田承一郎
        日本分子生物学会年会プログラム・講演要旨集, 1999
      • 細胞間接着部位に局在するTransglutaminaseの解析
        柊卓志; 月田承一郎
        日本分子生物学会年会プログラム・講演要旨集, 1998
      • 細胞間接着部位に局在するtransglutaminaseの解析
        柊卓志; 永淵昭良; 米田耕造; 月田承一郎
        日本細胞生物学会大会講演要旨集, 1997

      Presentations

      • Optimality for developmental robustness
        Takashi Hiiragi
        Bioimaging/LSI Lightsheet Microscopy Symposium, 22 Apr. 2024, Invited
      • Multicellular coordination in space and time
        Takashi Hiiragi
        UCL Department of Cell and Developmental Biology seminar, 27 Apr. 2023, Invited
      • Multicellular coordination in context
        Takashi Hiiragi
        Institute Seminar, Institut Jacques Monod, 28 Oct. 2022, Invited
      • Multicellular coordination in context
        Takashi Hiiragi
        Seminar, University of California San Francisco, Aug. 2022, Invited
      • Self-organisation in mouse development
        Takashi Hiiragi
        Belgian Society for Cell and Developmental Biology (BSCDB) meeting, “Mechanobiology in cell biology and development”, 29 Oct. 2021, Invited
      • Symmetry breaking and self-organization in mouse development
        Takashi Hiiragi
        Kavli Institute for Theoretical Physics conference “Symmetries in Morphogenesis: from Mechanisms to Principles”, 21 Oct. 2020, Invited
      • Multicellular coordination in context
        Takashi Hiiragi
        From gametogenesis to embryo: basic research and clinical considerations, Nov. 2022, Invited
      • Self-organization in mammalian development
        Takashi Hiiragi
        Imaging Mouse Development, 19 Sep. 2022, Invited

      Awards

      • 22 Jun. 2016
        Elected to Charles Darwin Chair Professorship of Animal Embryology in University
      • 27 Apr. 2021
        EMBO member(European Molecular Biology Organization)

      External funds: Kakenhi

      • Spatio-temporal variabilities and robustness in pre-implantation mammalian development
        Grant-in-Aid for Scientific Research (S)
        Broad Section G
        Kyoto University
        柊 卓志
        From 05 Jul. 2021, To 31 Mar. 2026, Granted
        発生生物学;哺乳類初期発生;自己組織化;ロバストネス;トポロジー;種差
      • 哺乳類初期発生の時空間的ゆらぎと自己組織化機構の解明
        Grant-in-Aid for Scientific Research (A)
        Medium-sized Section 44:Biology at cellular to organismal levels, and related fields
        Kyoto University
        柊 卓志
        From 05 Apr. 2021, To 31 Mar. 2022, Discontinued
        哺乳類初期発生;自己組織化;ゆらぎ;ロバストネス;発生生物学
      • 新規遺伝子トラップによる、マウス初期胚パターン形成メカニズムの解明
        Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
        Biological Sciences
        Kyoto University
        柊 卓志
        From 01 Apr. 2010, To 31 Mar. 2012, Project Closed
        細胞分化;発生生物学;哺乳類生物学;細胞生物学
      • 単一細胞レベルの遺伝子発現プロファイルに基づく多能性獲得機構の解明
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        Kyoto University
        柊 卓志
        From 01 Apr. 2009, To 31 Mar. 2011, Project Closed
        細胞分化;発生生物学;哺乳類生物学;細胞生物学
      • Mechano-chemical crosstalk regulating tissue patterning
        Grant-in-Aid for Transformative Research Areas (A)
        Transformative Research Areas, Section (III)
        Kyoto University
        柊 卓志
        From 16 Jun. 2022, To 31 Mar. 2027, Granted
        発生生物学;哺乳類初期発生;力学ー化学相互作用;組織パターン形成;自律的秩序化
      • Mechanical self-transformation of living systems
        Grant-in-Aid for Transformative Research Areas (A)
        Transformative Research Areas, Section (III)
        Hokkaido University
        茂木 文夫
        From 16 Jun. 2022, To 31 Mar. 2027, Granted
        多細胞生物;形態形成;自律的秩序化;力;発生;力作用;自己組織化;細胞運命;多細胞システム;多細胞;共同研究;共同利用;国際シンポジウム;生体計測;細胞操作;秩序化;力学計測解析;力学化学フィードバック
      list
        Last Updated :2025/07/19

        Education

        Teaching subject(s)

        • From 01 Apr. 2025, To 31 Mar. 2026
          Fundamentals of Cell and Molecular Biology
          N486, Spring, Institute for Liberal Arts and Sciences, 2

        Participation in PhD Defense

        • Expression pattern of Runt-related transcription factor (RUNX) family members and the role of RUNX1 during kidney development
          Keiko Sakamoto, Graduate School of Medicine, Sub-chief Examiner
          24 Mar. 2025
        • The first 3D analysis of the sphenoid morphogenesis during the human embryonic period
          UTSUNOMIYA NATSUKO, Graduate School of Medicine, Sub-chief Examiner
          24 Sep. 2024
        • EBF1 limits the numbers of cochlear hair and supporting cells and forms the scala tympani and spiral limbus during inner ear development
          KAGOSHIMA HIROKI, Graduate School of Medicine, Sub-chief Examiner
          23 May 2024
        • Nucleome programming is required for the foundation of totipotency in mammalian germline development
          NAGANO MASAHIRO, Graduate School of Medicine, Chief Examiner
          24 Jul. 2023
        list
          Last Updated :2025/07/19

          Academic, Social Contribution

          Committee Memberships

          • From 2022, To Present
            Steering committee, Hubrecht Imaging Center
          • From 2021, To 2023
            Scientific Committee “Cell Biology, Developmental Biology and Evolution” (CE13), French Research Agency (ANR)
          • From 2017, To 2021
            Institutional Workshops (central facility) Committee, European Molecular Biology Laboratory (EMBL)
          • From 2016, To 2021
            Faculty member, F1000Prime
          • From 2013, To 2021
            Institutional Animal Care and Use Committee (IACUC), European Molecular Biology Laboratory (EMBL)
          • From 2013, To 2021
            Graduate Committee, European Molecular Biology Laboratory (EMBL)
          • From 2016, To 2019
            Course and Conference Committee, European Molecular Biology Laboratory (EMBL)

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