Basic Information

Affiliated programs (koza)

• Graduate School of Medicine, 医学専攻 粒子線腫瘍学医学, 助教

Professional Memberships

• From Apr. 2006, To Present

  Japan Neurosurgical Society
• International Society for Neutron Capture Therapy
• 日本中性子捕捉療法学会
• 日本癌学会
• 日本放射線腫瘍学会
• 日本脳腫瘍学会
• 日本放射線影響学会

Academic Degree

• MD, PhD(Nara Medical University)

Research History

• From Apr. 2019, To Present

  Institute for Integrated Radiation and Nuclear Science, Kyoto university, Particle Radiation Oncology Research Center, Assistant Professor
• From Apr. 2010, To Apr. 2019

  Research Reactor Institutes, Kyoto University, Particle Radiation Oncology Center, Assistant Professor
• From Sep. 2014, To Aug. 2015

  The Ohio State University, James Comprehensive Cancer Center, Visiting researcher
• From Apr. 2006, To Mar. 2008

  奈良県立医科大学, 脳神経外科
• From Apr. 2004, To Mar. 2006

  Nara Medical University, Nara Medical University Hospital, clinical trainee

Language of Instruction

• Japanese
• English

ID,URL

• J-Global ID

  201401022432557407

researchmap URL

• https://researchmap.jp/7000008912

Research

Research Topics, Overview of the research

• Research Topics

  Boron Neutron Capture Therapy for Malignant Brain Tumor, BiologicalResponse ofBrain to Particle radiation

Research Areas

• Life sciences, Tumor diagnostics and therapeutics, Boron Neutron Capture Therapy, Malignant Glioma, Radaiation Brain Necrosis

Papers

• The Early Response After Radiation Therapy on Three-Dimensional Oral Cancer Model Using Patient-Derived Cancer-Associated Fibroblasts

  Izumi Yamamoto; Kazuyo Igawa; Natsuko Kondo; Yoshinori Sakurai; Atsushi Fujimura; Kiyofumi Takabatake; Peng Huang; Hiroyuki Michiue; Soichiro Ibaragi; Kenji Izumi

  International Journal of Translational Medicine, 20 Mar. 2025

  
• 2方向の中性子照射と患者体位変換で実現した高悪性度髄膜腫へのホウ素中性子捕捉療法

  柏木 秀基; 川端 信司; 辻野 晃平; 竹内 孝治; 平松 亮; 野々口 直助; 古瀬 元雅; 呼 尚徳; 櫻井 良憲; 田中 浩基; 近藤 夏子; 鈴木 実; 小野 公二; 宮武 伸一; 鰐渕 昌彦

  日本癌治療学会学術集会抄録集, Oct. 2024

  
• The Effect of p53 Status of Tumor Cells on Radiosensitivity of Irradiated Tumors With Carbon-Ion Beams Compared With γ-Rays or Reactor Neutron Beams

  Masunaga S; Tatebe H; Nishimura Y; Tano K; Sanada Y; Moriwaki T; Sakurai Y; Tanaka H; Suzuki M; Kondo N; Maruhashi A; Ono K

  World J Oncol, Aug. 2015, Peer-reviewed

  Access this paper :

  
• Overcoming immunotherapy resistance and inducing abscopal effects with boron neutron immunotherapy (B-NIT).

  Takuya Fujimoto; Osamu Yamasaki; Noriyuki Kanehira; Hirokazu Matsushita; Yoshinori Sakurai; Naoya Kenmotsu; Ryo Mizuta; Natsuko Kondo; Takushi Takata; Mizuki Kitamatsu; Kazuyo Igawa; Atsushi Fujimura; Yoshihiro Otani; Makoto Shirakawa; Kunitoshi Shigeyasu; Fuminori Teraishi; Yosuke Togashi; Minoru Suzuki; Toshiyoshi Fujiwara; Hiroyuki Michiue

  Cancer science, 09 Aug. 2024

  
• BNCT pancreatic cancer treatment strategy with glucose-conjugated boron drug.

  Takuya Fujimoto; Fuminori Teraishi; Noriyuki Kanehira; Tomoyuki Tajima; Yoshinori Sakurai; Natsuko Kondo; Masahiro Yamagami; Atsushi Kuwada; Akira Morihara; Mizuki Kitamatsu; Atsushi Fujimura; Minoru Suzuki; Yutaka Takaguchi; Kunitoshi Shigeyasu; Toshiyoshi Fujiwara; Hiroyuki Michiue

  Biomaterials, 09 May 2024

  
• DNA damage and biological responses induced by Boron Neutron Capture Therapy (BNCT).

  Natsuko Kondo

  The Enzymes, 2022, Invited, Lead author, Corresponding author

  Access this paper :

  
• Profile of miRNAs in small extracellular vesicles released from glioblastoma cells treated by boron neutron capture therapy.

  Natsuko Kondo; Tadatoshi Kinouchi; Manabu Natsumeda; Juntaro Matsuzaki; Eishu Hirata; Yoshinori Sakurai; Masayasu Okada; Minoru Suzuki

  Journal of neuro-oncology, 10 Apr. 2024, Peer-reviewed, Lead author, Corresponding author

  Access this paper :

  
• Carborane-Containing Hydroxamate MMP Ligands for the Treatment of Tumors Using Boron Neutron Capture Therapy (BNCT): Efficacy without Tumor Cell Entry.

  Sebastian Flieger; Mao Takagaki; Natsuko Kondo; Marlon R Lutz Jr; Yash Gupta; Hiroki Ueda; Yoshinori Sakurai; Graham Moran; Prakasha Kempaiah; Narayan Hosmane; Minoru Suzuki; Daniel P Becker

  International journal of molecular sciences, 09 Apr. 2023

  
• Strategies for Preclinical Studies Evaluating the Biological Effects of an Accelerator-based BNCT System

  Natsuko Kondo; Mitsuko Masutani; Shoji Imamichi; Yoshitaka Matsumoto; Kei Nakai

  Cancer Biotherapy & Radiopharmaceuticals, Oct. 2022, Peer-reviewed, Invited, Lead author, Corresponding author

  
• Progress of Boron Neutron Capture Therapy and Biological Problems

  近藤 夏子; 櫻井 良憲; 高田 卓志; 田中 浩基; 鈴木 実

  Radiation Biology Research Communications, 18 Feb. 2022, Peer-reviewed, Lead author, Corresponding author

  
• Persistent elevation of lysophosphatidylcholine promotes radiation brain necrosis with microglial recruitment by P2RX4 activation

  Natsuko Kondo; Yoshinori Sakurai; Takushi Takata; Kuniyuki Kano; Kyo Kume; Munetoshi Maeda; Nobuhiko Takai; Shugo Suzuki; Fumihiro Eto; Kenji Kikushima; Hideki Wanibuchi; Shin-Ichi Miyatake; Takayuki Kajihara; Shoji Oda; Mitsutoshi Setou; Junken Aoki; Minoru Suzuki

  Scientific Reports, 24 May 2022, Peer-reviewed, Lead author, Corresponding author

  Access this paper :

  
• Boron neutron capture therapy and add-on bevacizumab in patients with recurrent malignant glioma.

  Motomasa Furuse; Shinji Kawabata; Masahiko Wanibuchi; Hiroyuki Shiba; Koji Takeuchi; Natsuko Kondo; Hiroki Tanaka; Yoshinori Sakurai; Minoru Suzuki; Koji Ono; Shin-Ichi Miyatake

  Japanese journal of clinical oncology, 26 Jan. 2022

  
• BNCT for primary synovial sarcoma.

  Takuya Fujimoto; Minoru Suzuki; Shigeyuki Kuratsu; Ikuo Fujita; Masayuki Morishita; Tamotsu Sudo; Toshiko Sakuma; Yuta Nakamatsu; Yoshinori Sakurai; Takushi Takata; Yuki Tamari; Hiroki Tanaka; Shin-Ichiro Masunaga; Yuko Kinashi; Natsuko Kondo; Shunsuke Sakakibara; Hiroshi Igaki; Tooru Andoh; Setsu Sakamoto; Teruya Kawamoto; Tadashi Watabe; Hitomi Hara; Naomasa Fukase; Yohei Kawakami; Tomoyuki Matsumoto; Toshihiro Akisue; Koji Ono; Hideki Ichikawa; Ryosuke Kuroda; Takanori Hirose

  Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, Mar. 2021, Peer-reviewed

  
• Self-assembling A6K peptide nanotubes as a mercaptoundecahydrododecaborate (BSH) delivery system for boron neutron capture therapy (BNCT).

  Hiroyuki Michiue; Mizuki Kitamatsu; Asami Fukunaga; Nobushige Tsuboi; Atsushi Fujimura; Hiroaki Matsushita; Kazuyo Igawa; Tomonari Kasai; Natsuko Kondo; Hideki Matsui; Shuichi Furuya

  Journal of controlled release : official journal of the Controlled Release Society, 10 Feb. 2021, Peer-reviewed

  
• Glioma Stem-Like Cells Can Be Targeted in Boron Neutron Capture Therapy with Boronophenylalanine.

  Natsuko Kondo; Masaki Hikida; Mitsutoshi Nakada; Yoshinori Sakurai; Eishu Hirata; Satoshi Takeno; Minoru Suzuki

  Cancers, 19 Oct. 2020, Peer-reviewed, Lead author, Corresponding author

  
• Boron Neutron Capture Therapy Combined with Early Successive Bevacizumab Treatments for Recurrent Malignant Gliomas - A Pilot Study.

  Hiroyuki Shiba; Koji Takeuchi; Ryo Hiramatsu; Motomasa Furuse; Naosuke Nonoguchi; Shinji Kawabata; Toshihiko Kuroiwa; Natsuko Kondo; Yoshinori Sakurai; Minoru Suzuki; Koji Ono; Shiro Oue; Eiichi Ishikawa; Hiroyuki Michiue; Shin-Ichi Miyatake

  Neurologia medico-chirurgica, 15 Dec. 2018, Peer-reviewed

  
• Boron neutron capture therapy (BNCT) for the patients with recurrent malignant glioma using nuclear reactor

  Kawabata Shinji; Hiramatsu Ryo; Matsushita Yoko; Fujishiro Takahiro; Furuse Motomasa; Kuroiwa Toshihiko; Kondo Natsuko; Miyatake Shin-ichi; Ono Koji

  CANCER SCIENCE, Dec. 2018, Peer-reviewed

  
• RTHP-38. BNCT COMBINED WITH EARLY SUCCESSIVE BEVACIZUMAB TREATMENTS FOR RECURRENT MALIGNANT GLIOMAS

  Shin-Ichi Miyatake; Hiroyuki Shiba; Shinji Kawabata; Toshihiko Kuroiwa; Natsuko Kondo; Yoshinori Sakurai; Minoru Suzuki; Koji Ono

  Neuro-Oncology, Nov. 2018, Peer-reviewed

  
• ELUCIDATION OF PHOSPHOLIPID ALTERATION IN BRAIN AFTER IRRADIATION USING BRAIN RADIATION NECROSIS MOUSE MODEL

  Natsuko Kondo; Kenji Nakayama; Yoshinori Sakurai; Takushi Takata; Kyo Kume; Shin-Ichi Miyatake; Osamu Ogawa; Minoru Suzuki

  NEURO-ONCOLOGY, Nov. 2017, Peer-reviewed

  
• ACTR-09. BORON NEUTRON CAPTURE THERAPY WITH THE COMBINATION OF SUCCESSIVE BEVACIZUMAB TREATMENTS FOR RECURRENT MALIGNANT GLIOMAS

  Shin-Ichi Miyatake; Shinji Kawabata; Motomasa Furuse; Naosuke Nonoguchi; Toshihiko Kuroiwa; Natsuko Kondo; Yoshinori Sakurai; Minoru Suzuki; Koji Ono

  Neuro-Oncology, Nov. 2017, Peer-reviewed

  
• Effect of Tirapazamine, Metformin or Mild Hyperthermia on Recovery From Radiation-Induced Damage in Pimonidazole-Unlabeled Quiescent Tumor Cells.

  Masunaga SI; Tano K; Sanada Y; Sakurai Y; Tanaka H; Suzuki M; Kondo N; Watanabe T; Takata T; Maruhashi A; Ono K

  World journal of oncology, Oct. 2017, Peer-reviewed

  
• Cerebrospinal fluid dissemination of high-grade gliomas following boron neutron capture therapy occurs more frequently in the small cell subtype of IDH1R132H mutation-negative glioblastoma.

  Natsuko Kondo; Rolf F Barth; Shin-Ichi Miyatake; Shinji Kawabata; Minoru Suzuki; Koji Ono; Norman L Lehman

  Journal of neuro-oncology, May 2017, Peer-reviewed

  
• Boron Neutron Capture Therapy for Malignant Brain Tumors

  S.-I. Miyatake; S. Kawabata; R. Hiramatsu; T. Kuroiwa; M. Suzuki; N. Kondo; H. Tanaka; K. Ono

  WFNOS Magazine, 2017, Peer-reviewed

  
• Effects on the microvessel density and astrocytic activation after local brain irradiation with carbon ions.

  Matsumoto, Yoshitaka; 高井伸彦; 鵜澤玲子; 近藤夏子; 櫻井良憲; 古澤佳也; 平山亮一; 中村沙織; 大庭義史

  2015 Annual Report of the Research Project with Heavy Ions at NIRS-HIMAC, Sep. 2016

  
• Boron Neutron Capture Therapy for Malignant Brain Tumors.

  Shin-Ichi Miyatake; Shinji Kawabata; Ryo Hiramatsu; Toshihiko Kuroiwa; Minoru Suzuki; Natsuko Kondo; Koji Ono

  Neurologia medico-chirurgica, 15 Jul. 2016, Peer-reviewed

  
• DNA damage induced by boron neutron capture therapy is partially repaired by DNA ligase IV.

  Natsuko Kondo; Yoshinori Sakurai; Yuki Hirota; Hiroki Tanaka; Tsubasa Watanabe; Yosuke Nakagawa; Masaru Narabayashi; Yuko Kinashi; Shin-ichi Miyatake; Masatoshi Hasegawa; Minoru Suzuki; Shin-ichiro Masunaga; Takeo Ohnishi; Koji Ono

  Radiation and environmental biophysics, Mar. 2016, Peer-reviewed, Lead author, Corresponding author

  
• Detection of γH2AX foci in mouse normal brain and brain tumor after boron neutron capture therapy

  Natsuko Kondo; Hiroyuki Michiue; Yoshinori Sakurai; Hiroki Tanaka; Yosuke Nakagawa; Tsubasa Watanabe; Masaru Narabayashi; Yuko Kinashi; Minoru Suzuki; Shin-Ichiro Masunaga; Koji Ono

  Reports of Practical Oncology and Radiotherapy, 01 Mar. 2016, Peer-reviewed, Lead author, Corresponding author

  
• Effect of oxygen pressure during incubation with a (10)B-carrier on (10)B uptake capacity of cultured p53 wild-type and mutated tumor cells: dependency on p53 status of tumor cells and types of (10)B-carriers.

  Shin-ichiro Masunaga; Hitoshi Tatebe; Yasumasa Nishimura; Keizo Tano; Yu Sanada; Takahiro Moriwaki; Yoshinori Sakurai; Hiroki Tanaka; Minoru Suzuki; Natsuko Kondo; Akira Maruhashi; Koji Ono

  International journal of radiation biology, 2016, Peer-reviewed

  
• Localized radiation necrosis model in mouse brain using proton ion beams

  Natsuko Kondo; Yoshinori Sakurai; Takushi Takata; Nobuhiko Takai; Yosuke Nakagawa; Hiroki Tanaka; Tsubasa Watanabe; Kyo Kume; Taichiro Toho; Shin-ichi Miyatake; Minoru Suzuki; Shin-ichiro Masunaga; Koji Ono

  APPLIED RADIATION AND ISOTOPES, Dec. 2015, Peer-reviewed, Lead author, Corresponding author

  
• Localized dose delivering by ion beam irradiation for experimental trial of establishing brain necrosis model (Reprinted)

  Takushi Takata; Natsuko Kondo; Yoshinori Sakurai; Hiroki Tanaka; Takashi Hasegawa; Kyo Kume; Minoru Suzuki

  APPLIED RADIATION AND ISOTOPES, Dec. 2015, Peer-reviewed

  
• Localized dose delivering by ion beam irradiation for experimental trial of establishing brain necrosis model.

  Takushi Takata; Natsuko Kondo; Yoshinori Sakurai; Hiroki Tanaka; Takashi Hasegawa; Kyo Kume; Minoru Suzuki

  Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, Nov. 2015, Peer-reviewed

  
• Development of a dual phantom technique for measuring the fast neutron component of dose in boron neutron capture therapy.

  Yoshinori Sakurai; Hiroki Tanaka; Natsuko Kondo; Yuko Kinashi; Minoru Suzuki; Shinichiro Masunaga; Koji Ono; Akira Maruhashi

  Medical physics, Nov. 2015, Peer-reviewed

  
• 陽子線・ヘリウム線による脳壊死モデル作成技術の確立―放射線脳壊死のメカニズム解明と治療法開発を目指して―

  近藤夏子; 櫻井良憲; 高田卓志; 田中浩基; 渡邉翼; 鈴木実; 前田宗利; 伊東富由美; 久米恭

  若狭湾エネルギー研究センター研究年報, Oct. 2015, Lead author

  
• Improvement of depth dose distribution using multiple-field irradiation in boron neutron capture therapy

  Nozomi Fujimoto; Hiroki Tanaka; Yoshinori Sakurai; Takushi Takata; Natsuko Kondo; Masaru Narabayashi; Yosuke Nakagawa; Tsubasa Watanabe; Yoko Kinashi; Shin-ichiro Masunaga; Akira Maruhashi; Koji Ono; Minoru Suzuki

  Applied Radiation and Isotopes, 2015, Peer-reviewed

  
• Advances in Boron Neutron Capture Therapy (BNCT) at Kyoto University From Reactor-based BNCT to Accelerator-based BNCT

  Yoshinori Sakurai; Hiroki Tanaka; Takushi Takata; Nozomi Fujimoto; Minoru Suzuki; Shin-ichiro Masunaga; Yuko Kinashi; Natsuko Kondo; Masaru Narabayashi; Yosuke Nakagawa; Tsubasa Watanabe; Koji Ono; Akira Maruhashi

  Journal of the Korean Physical Society, 2015, Peer-reviewed

  Access this paper :

  
• A case of radiation-induced osteosarcoma treated effectively by boron neutron capture therapy.

  Gen Futamura; Shinji Kawabata; Hiroyuki Siba; Toshihiko Kuroiwa; Minoru Suzuki; Natsuko Kondo; Koji Ono; Yoshinori Sakurai; Minoru Tanaka; Tomoki Todo; Shin-Ichi Miyatake

  Radiation oncology (London, England), 04 Nov. 2014, Peer-reviewed

  
• Significance of Fractionated Administration of Thalidomide Combined With γ-Ray Irradiation in Terms of Local Tumor Response and Lung Metastasis.

  Masunaga SI; Sanada Y; Moriwaki T; Tano K; Sakurai Y; Tanaka H; Suzuki M; Kondo N; Narabayashi M; Watanabe T; Nakagawa Y; Maruhashi A; Ono K

  World journal of oncology, Aug. 2014, Peer-reviewed

  
• Effect of bevacizumab combined with boron neutron capture therapy on local tumor response and lung metastasis.

  Shin-Ichiro Masunaga; Yoshinori Sakurai; Keizo Tano; Hiroki Tanaka; Minoru Suzuki; Natsuko Kondo; Masaru Narabayashi; Tsubasa Watanabe; Yosuke Nakagawa; Akira Maruhashi; Koji Ono

  Experimental and therapeutic medicine, Jul. 2014, Peer-reviewed

  Access this paper :

  
• Dose estimation for internal organs during boron neutron capture therapy for body-trunk tumors

  Y. Sakurai; H. Tanaka; M. Suzuki; S. Masunaga; Y. Kinashi; N. Kondo; K. Ono; A. Maruhashi

  APPLIED RADIATION AND ISOTOPES, Jun. 2014, Peer-reviewed

  
• Evaluation of thermal neutron irradiation field using a cyclotron-based neutron source for alpha autoradiography

  H. Tanaka; Y. Sakurai; M. Suzuki; S. Masunaga; T. Mitsumoto; Y. Kinashi; N. Kondo; M. Narabayashi; Y. Nakagawa; T. Watanabe; N. Fujimoto; A. Maruhashi; K. Ono

  APPLIED RADIATION AND ISOTOPES, Jun. 2014, Peer-reviewed

  
• Pilot clinical study of boron neutron capture therapy for recurrent hepatic cancer involving the intra-arterial injection of a (10)BSH-containing WOW emulsion.

  Hironobu Yanagie; Syushi Higashi; Koji Seguchi; Ichiro Ikushima; Mituteru Fujihara; Yasumasa Nonaka; Kazuyuki Oyama; Syoji Maruyama; Ryo Hatae; Minoru Suzuki; Shin-ichiro Masunaga; Tomoko Kinashi; Yoshinori Sakurai; Hiroki Tanaka; Natsuko Kondo; Masaru Narabayashi; Tetsuya Kajiyama; Akira Maruhashi; Koji Ono; Jun Nakajima; Minoru Ono; Hiroyuki Takahashi; Masazumi Eriguchi

  Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, Jun. 2014, Peer-reviewed

  
• The BRCA2 gene is a potential molecular target during 5-fluorouracil therapy in human oral cancer cells

  Yosuke Nakagawa; Atsuhisa Kajihara; Akihisa Takahashi; Natsuko Kondo; Eiichiro Mori; Tadaaki Kirita; Takeo Ohnishi

  ONCOLOGY REPORTS, May 2014, Peer-reviewed

  
• The acceleration of boron neutron capture therapy using multi-linked mercaptoundecahydrododecaborate (BSH) fused cell-penetrating peptide.

  Hiroyuki Michiue; Yoshinori Sakurai; Natsuko Kondo; Mizuki Kitamatsu; Feng Bin; Kiichiro Nakajima; Yuki Hirota; Shinji Kawabata; Tei-ichi Nishiki; Iori Ohmori; Kazuhito Tomizawa; Shin-ichi Miyatake; Koji Ono; Hideki Matsui

  Biomaterials, Mar. 2014, Peer-reviewed

  
• 悪性神経膠腫の放射線治療後再発例に対するホウ素中性子捕捉療法の成績

  川端信司; 平松亮; 古瀬元雅; 松下葉子; 二村元; 大西宏之; 黒岩敏彦; 近藤夏子; 鈴木実; 櫻井良憲; 田中浩基; 小野公二; 宮武伸一

  定位的放射線治療, 08 Jan. 2014

  
• Clinical experiences of boron neutron capture therapy to recurrenced rectal cancers

  H.Yanagie; K.Oyama; R.Hatae; S.Maruyama; Y.Ohno; S.Kurokawa; Y.Nonaka; H.Sugiyama; Y.Furuya; K.Taniike; M.Suzuki; S.Masunaga; T.Kinashi; Y.Sakurai; N.Kondo; M.Narabayashi; H.Tanaka; A.Maruhashi; K.Ono; J.Nakajima; M.Ono; H.Takahashi; M.Eriguchi

  Book of Abstracts for 16th International Congress on Neutron Capture Therapy, Cancer Society of Finland, 2014

  
• Novel multi-linked mercaptoundecahydrododecaborate (BSH) fused cellpenetrating peptide accelerated boron neutron capture therapy (BNCT)

  H.Michiue; Y.Sakurai; N.Kondo; M.Kitamatsu; F.Bin; K.Nakajima; Y.Hirota; S.Kawabata; T.Nishiki; I.Ohmori; K.Tomizawa; S.Miyatake; K.Ono; H.Matsui

  Book of Abstracts for 16th International Congress on Neutron Capture Therapy, Cancer Society of Finland, 2014

  
• Experimental trial of establishing brain necrosis mouse model using proton beam

  N.Kondo; Y.Sakurai; T.Takata; H.Tanaka; N.Takai; K.Kume; T.Watanabe; T.Toho; S.Miyatake; M.Suzuki; S.Masunaga; K.Ono

  Book of Abstracts for 16th International Congress on Neutron Capture Therapy, Cancer Society of Finland, 2014, Lead author, Corresponding author

  
• Study on the accelerator-based neutron source using Be(p,n) reaction with proton energy of lower than 30 MeV

  H.Tanaka; Y.Sakurai; M.Suzuki; S.Masunaga; N.Fujimoto; Y.Kinashi; N.Kondo; T.Takata; T.Watanabe; M.Narabayashi; A.Maruhashi; K.Ono

  Book of Abstracts for 16th International Congress on Neutron Capture Therapy, Cancer Society of Finland, 2014

  
• A study of effective dose for tumor in BNCT

  Y.Sakurai; H.Tanaka; N.Fujimoto; N.Kondo; M.Narabayashi; Y.Nakagawa; T.Watanabe; Y.Kinashi; M.Suzuki; S.Masunaga; A.Maruhashi; K.Ono

  Book of Abstracts for 16th International Congress on Neutron Capture Therapy, Cancer Society of Finland, 2014

  
• Study on the improvement of depth dose distribution using multiple-field irradiation in boron neutron capture therapy

  N.Fujimoto; H.Tanaka; Y.Sakurai; N.Kondo; M.Narabayashi; Y.Nakagawa; T.Watanabe; Y.Kinashi; S.Masunaga; A.Maruhashi; K.Ono; M.Suzuki

  Book of Abstracts for 16th International Congress on Neutron Capture Therapy, Cancer Society of Finland, 2014

  
• Significance of Administering Bevacizumab Combined with Boron Neutron Capture Therapy in Terms of Local Tumor Control and Lung Metastatic Potential

  Shin-ichiro Masunaga; Yoshinori Sakurai; Keizo Tano; Hiroki Tanaka; Minoru Suzuki; Natsuko Kondo; Masaru Narabayashi; Tsubasa Watanabe; Yosuke Nakagawa; Akira Maruhashi; Koji Ono

  International Journal of Radiation Oncology, Biology, Physics, 2014, Peer-reviewed

  
• The dependency of compound biological effectiveness factors on the type and the concentration of administered neutron capture agents in boron neutron capture therapy.

  Shin-Ichiro Masunaga; Yoshinori Sakurai; Hiroki Tanaka; Keizo Tano; Minoru Suzuki; Natsuko Kondo; Masaru Narabayashi; Yosuke Nakagawa; Tsubasa Watanabe; Akira Maruhashi; Koji Ono

  SpringerPlus, 2014, Peer-reviewed

  Access this paper :

  
• High linear-energy-transfer radiation can overcome radioresistance of glioma stem-like cells to low linear-energy-transfer radiation

  Yuki Hirota; Shin-Ichiro Masunaga; Natsuko Kondo; Shinji Kawabata; Hirokazu Hirakawa; Hirohiko Yajima; Akira Fujimori; Koji Ono; Toshihiko Kuroiwa; Shin-Ichi Miyatake

  JOURNAL OF RADIATION RESEARCH, Jan. 2014, Peer-reviewed

  
• Effect of tirapazamine and mild temperature hyperthermia on the recovery from radiation-induced damage in pimonidazole-unlabeled quiescent tumor cell population

  Masunaga S; Sakurai Y; Tanaka H; Suzuki M; Kondo N; Narabayashi M; Tano K; Maruhashi A; Ono K

  J. Canc. Ther., Apr. 2013, Peer-reviewed

  
• Wortmannin efficiently suppresses the recovery from radiation-induced damage in pimonidazole-unlabeled quiescent tumor cell population

  Shin-ichiro Masunaga; Yoshinori Sakurai; Hiroki Tanaka; Minoru Suzuki; Natsuko Kondo; Masaru Narabayashi; Akira Maruhashi; Koji Ono

  JOURNAL OF RADIATION RESEARCH, Mar. 2013, Peer-reviewed

  Access this paper :

  
• Usefulness of Daily Fractionated Administration of Wortmannin Combined With γ-Ray Irradiation in Terms of Local Tumor Response and Lung Metastasis.

  Masunaga SI; Sakurai Y; Tanaka H; Suzuki M; Kondo N; Narabayashi M; Tano K; Maruhashi A; Ono K

  World journal of oncology, Feb. 2013, Peer-reviewed

  
• 硼素中性子捕捉療法がゲル線量計に望むこと

  櫻井良憲; 楢林正流; 林 慎一郎; 藤本 望; 田中浩基; 近藤夏子; 木梨友子; 増永慎一郎; 鈴木 実; 小野公二

  第2回3Ｄゲル線量計研究会予稿集, 2013

  
• The dependency of compound biological effectiveness factors on the type and concentration of administered neutron capture agents in BNCT

  S.Masunaga; K.Tano; Y.Sakurai; H.Tanaka; M.Suzuki; N.Kondo; M.Narabayashi; T.Watanabe; A.Maruhashi; K.Ono

  Book of Abstracts for 7th Young Researchers’ Boron Neutron Capture Therapy Meeting, 2013

  
• Detection of gamma H2AX foci in mouse brain tissue after neutron capture therapy

  N.Kondo; M.Narabayashi; T.Watanabe; H.Tanaka; Y.Sakurai; Y.Kinashi; M.Suzuki; S.Masunaga; K.Ono

  Book of Abstracts for 7th Young Researchers’ Boron Neutron Capture Therapy Meeting, 2013, Lead author, Corresponding author

  
• Study on the evaluation of 10B concentration using proton-induced prompt gamma ray analysis for BNCT

  H.Tanaka; Y.Sakurai; R.Uchida; T.Kawamura; H.Tsuchida; M.Suzuki; S.Masunaga; N.Kondo; M.Narabayashi; K.Ono; A.Marunashi

  Book of Abstracts for 7th Young Researchers’ Boron Neutron Capture Therapy Meeting, 2013

  
• A study of boron-dose estimation using boron concentration in plasma

  Y.Sakurai; H.Tanaka; M.Suzuki; S.Masunaga; Y.Kinashi; N.Kondo; M.Narabayashi; N.Fujimoto; A.Maruhashi; K.Ono

  Book of Abstracts for 7th Young Researchers’ Boron Neutron Capture Therapy Meeting, 2013

  
• Study on epithermal neutron source using Be(p,n) reaction with proton energy of 16 MeV

  H.Tanaka; Y.Sakurai; M.Suzuki; S.Masunaga; M.Narabayashi; Y.Kinashi; N.Kondo; A.Maruhashi; K.Ono

  Book of Abstracts for 20th International Conference on Medical Physics (ICMP2013), 2013

  
• The Benefit of High LET-Radiation to Glioma Stem-Like Cells

  Hirota Y; Masunaga S; Kondo N; Fujishiro T; Kawabata S; Fujimori A; Hirakawa H; Yajima H; Ono K; Kuroiwa T; Miyatake S

  Progress Report 2012, The Research Reactor Institute, Kyoto University, 2013

  
• Radiosensitivity of pimonidazole-unlabelled intratumour quiescent cell population to γ-rays, accelerated carbon ion beams and boron neutron capture reaction

  Shin-Ichiro Masunaga; Y. Sakurai; H. Tanaka; R. Hirayama; Y. Matsumoto; A. Uzawa; M. Suzuki; N. Kondo; M. Narabayashi; A. Maruhashi; K. Ono

  British Journal of Radiology, 01 Jan. 2013, Peer-reviewed

  Access this paper :

  
• Reirradiation for locally recurrent lung cancer in the chest wall with boron neutron capture therapy (BNCT): A case report.

  Suzuki M; Suzuki O; Sakurai Y; Tanaka H; Kondo N; Kinashi Y; Masunaga S; Maruhashi A; Ono K

  Int Cancer Conference J, Sep. 2012, Peer-reviewed

  
• Evaluating the Usefulness of a Novel 10B-Carrier Conjugated With Cyclic RGD Peptide in Boron Neutron Capture Therapy.

  Shin-Ichiro Masunaga; Sadaaki Kimura; Tomohiro Harada; Kensuke Okuda; Yoshinori Sakurai; Hiroki Tanaka; Minoru Suzuki; Natsuko Kondo; Akira Maruhashi; Hideko Nagasawa; Koji Ono

  World journal of oncology, Jun. 2012, Peer-reviewed

  
• Effects of employing a B-10-carrier and manipulating intratumour hypoxia on local tumour response and lung metastatic potential in boron neutron capture therapy

  S. Masunaga; Y. Sakurai; H. Tanaka; M. Suzuki; Y. Liu; N. Kondo; A. Maruhashi; Y. Kinashi; K. Ono

  BRITISH JOURNAL OF RADIOLOGY, Mar. 2012, Peer-reviewed

  
• Impact of employing 10B-carriers and manipulating intratumor hypoxia on local tumor response and lung metastatic potential in boron neutron capture therapy

  Masunaga S; Sakurai Y; Tanaka H; Suzuki M; Kondo N; Maruhashi A; Ono K

  Radiother Oncol, Feb. 2012, Peer-reviewed

  
• Development of thermal neutron flux monitor using small scintillator array coupled with quartz fibers for Boron Neutron Capture Therapy

  Hiroki Tanaka; Yoshinori Sakurai; Minoru Suzuki; Shinichiro Masunaga; Yuko Kinashi; Natsuko Kondo; Yuji Kawabata; Takahiro Yagi; Tsuyoshi Misawa; Koji Ono; Akira Maruhashi

  IEEE Nuclear Science Symposium Conference Record, 2012, Peer-reviewed

  
• Boronをトレーサーとする薬物の動態解析法の開発

  堀 均; 宇都義浩; 中田栄司; 小泉允人; 那住善治郎; 多田 竜; 近藤夏子; 櫻井良憲; 高橋千太郎; 小野公二

  京大原子炉実験所第46回学術講演会報文集，京大原子炉実験所, 2012

  
• Reducing intratumnor acute hypoxia through bevacizumab treatment、 referring to distant metastatic potential.

  Masunaga S; Tanaka H; Sakurai Y; Suzuki M; Kondo N; Narabayashi M; Maruhashi A; Ono K

  KURRI Progress Report, 2012

  
• Boron neutron capture therapy for malignant pleuritis.

  Ono K; Suzuki M; Masunaga S; Kondo N; Narabayashi M; Sakurai Y; Tanaka H; Kinashi Y; Maruhashi A

  KURRI Progress Report, 2012

  
• Boron neutron capture therapy for malignant brain tumors using epithermal neutron.

  Miyatake S; Kawabata S; Hiramatsu R; Hirota Y; Kuroiwa T; Sakurai Y; Tanaka H; Maruhashi A; Suzuki M; Kondo N; Masunaga S; Kinashi Y; Ono K

  KURRI Progress Report, 2012

  
• BNCT case report of malignant brain tumor 2011.

  Tchizawa T; Takagaki M; Tanaka H; Sakurai Y; Suzuki M; Maruhashi A; Kondo N; Masunaga; Ono K

  KURRI Progress Report, 2012

  
• Usefulness of combined treatment with continuous administration of tirapazamine and mild temperature hyperthermia in gamma-ray irradiation in terms of local tumour response and lung metastatic potential

  Shin-Ichiro Masunaga; Yong Liu; Yoshinori Sakurai; Hiroki Tanaka; Minoru Suzuki; Natsuko Kondo; Akira Maruhashi; Koji Ono

  INTERNATIONAL JOURNAL OF HYPERTHERMIA, 2012, Peer-reviewed

  Access this paper :

  
• Current Status of Cyclotron-Based Epithermal Neutron Source for BNCT

  Tanaka H; Sakurai Y; Suzuki M; Masunaga S; Kinashi Y; Kondo N; Mitsumoto T; Maruhashi A; Ono K

  6th Young Researchers Boron Neutron Capture Therapy Meeting, Dec. 2011, Peer-reviewed

  
• Reducing intratumour acute hypoxia through bevacizumab treatment, referring to the response of quiescent tumour cells and metastatic potential

  S. Masunaga; Y. Liu; H. Tanaka; Y. Sakurai; M. Suzuki; N. Kondo; A. Maruhashi; K. Ono

  BRITISH JOURNAL OF RADIOLOGY, Dec. 2011, Peer-reviewed

  Access this paper :

  
• Nitric Oxide Radical-induced Radioadaptation and Radiosensitization Are G(2)/M Phase-dependent

  Xiaoming Su; Akihisa Takahashi; Natsuko Kondo; Yosuke Nakagawa; Toshiyasu Iwasaki; Guozhen Guo; Takeo Ohnishi

  JOURNAL OF RADIATION RESEARCH, Sep. 2011, Peer-reviewed

  
• Nitric Oxide Radical-induced Radioadaptation and Radiosensitization Are G(2)/M Phase-dependent

  Xiaoming Su; Akihisa Takahashi; Natsuko Kondo; Yosuke Nakagawa; Toshiyasu Iwasaki; Guozhen Guo; Takeo Ohnishi

  JOURNAL OF RADIATION RESEARCH, Sep. 2011, Peer-reviewed

  
• Design, synthesis and destructive dynamic effects of BODIPY-containing and curcuminoid boron tracedrugs for neutron dynamic therapy.

  Eiji Nakata; Masato Koizumi; Yohei Yamashita; Kenta Onaka; Yoshinori Sakurai; Natsuko Kondo; Koji Ono; Yoshihiro Uto; Hitoshi Hori

  Anticancer research, Jul. 2011, Peer-reviewed

  
• FANCD1/BRCA2 Plays Predominant Role in the Repair of DNA Damage Induced by ACNU or TMZ

  Natsuko Kondo; Akihisa Takahashi; Eiichiro Mori; Taichi Noda; Malgorzata Z. Zdzienicka; Larry H. Thompson; Thomas Helleday; Minoru Suzuki; Yuko Kinashi; Shinichiro Masunaga; Koji Ono; Masatoshi Hasegawa; Takeo Ohnishi

  PLOS ONE, May 2011, Peer-reviewed, Lead author

  
• 【基礎と臨床の対話】寡分割照射の基礎と臨床 休止期腫瘍細胞の挙動から見た分割照射

  増永 慎一郎; 櫻井 良憲; 菓子野 元郎; 鈴木 実; 田中 浩基; 劉 勇; 近藤 夏子; 木梨 友子; 平山 亮一; 松本 孔貴; 鵜澤 玲子; 小池 幸子; 安藤 興一; 丸橋 晃; 小野 公二

  癌の臨床, Apr. 2011, Peer-reviewed

  
• Radiosensitivity and Capacity to Recover from Radiation-Induced Damage in Pimonidazole-Unlabeled Intratumor Quiescent Cells Depend on p53 Status.

  Masunaga SI; Liu Y; Tanaka H; Sakurai Y; Suzuki M; Kondo N; Maruhashi A; Ono K

  World journal of oncology, Feb. 2011, Peer-reviewed

  
• Repair pathways independent of the Fanconi anemia nuclear core complex play a predominant role in mitigating formaldehyde-induced DNA damage

  Taichi Noda; Akihisa Takahashi; Natsuko Kondo; Eiichiro Mori; Noritomo Okamoto; Yosuke Nakagawa; Ken Ohnishi; Malgorzata Z. Zdzienicka; Larry H. Thompson; Thomas Helleday; Hideo Asada; Takeo Ohnishi

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jan. 2011, Peer-reviewed

  
• siRNA targeted for NBS1 enhances heat sensitivity in human anaplastic thyroid carcinoma cells

  Noritomo Okamoto; Akihisa Takahashi; Ichiro Ota; Ken Ohnishi; Eiichiro Mori; Natsuko Kondo; Taichi Noda; Yosuke Nakagawa; Hirokazu Uemura; Katunari Yane; Hiroshi Hosoi; Takeo Ohnishi

  INTERNATIONAL JOURNAL OF HYPERTHERMIA, 2011, Peer-reviewed

  
• DNA ligase IV is a potential molecular target in ACNU sensitivity

  Natsuko Kondo; Akihisa Takahashi; Eiichiro Mori; Taichi Noda; Xiaoming Su; Ken Ohnishi; Peter J. McKinnon; Toshisuke Sakaki; Hiroyuki Nakase; Koji Ono; Takeo Ohnishi

  CANCER SCIENCE, Aug. 2010, Peer-reviewed, Lead author

  
• ATM is the Predominant Kinase Involved in the Phosphorylation of Histone H2AX after Heating

  Akihisa Takahashi; Eiichiro Mori; Xiaoming Su; Yosuke Nakagawa; Noritomo Okamoto; Hirokazu Uemura; Natsuko Kondo; Taichi Noda; Atsushi Toki; Yosuke Ejima; David J. Chen; Ken Ohnishi; Takeo Ohnishi

  JOURNAL OF RADIATION RESEARCH, Jul. 2010, Peer-reviewed

  
• The Response of Quiescent Tumor Cells to Fractionated Irradiation

  増永慎一郎; 櫻井良憲; 菓子野元郎; 鈴木実; 田中浩基; LIU Y; 近藤夏子; 木梨友子; 平山亮一; 松本孔貴; 鵜澤玲子; 小池幸子; 安藤興一; 丸橋晃; 小野公二

  癌の臨床, Jun. 2010

  
• 加速器中性子源によるホウ素中性子捕捉療法の展望

  小野公二; 鈴木 実; 増永慎一郎; 劉 勇; 近藤夏子; 木梨友子; 菓子野元郎; 櫻井良憲; 田中浩基; 丸橋 晃

  映像情報メディカル, 2010

  
• Effective new cancer therapies which are independent of P53 gene status

  A. Takahashi; K. Ohnishi; N. Kondo; E. Mori; T. Noda; T. Ohnishi

  Journal of Nara Medical Association, 2010, Peer-reviewed

  
• DNA damage induced by alkylating agents and repair pathways

  Natsuko Kondo; Akihisa Takahashi; Koji Ono; Takeo Ohnishi

  Journal of Nucleic Acids, 2010, Peer-reviewed, Lead author

  
• DNA ligase IV as a new molecular target for temozolomide

  Natsuko Kondo; Akihisa Takahashi; Eiichiro Mori; Ken Ohnishi; Peter J. McKinnon; Toshisuke Sakaki; Hiroyuki Nakase; Takeo Ohnishi

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Oct. 2009, Peer-reviewed, Lead author

  
• Alkylating agents-induced DNA damage- Repair Mechanisms and Application for Cancer Therapy

  N. Kondo; A. Takahashi; T. Ohnishi

  Radiat. Biol. Res. Commun, 2009, Lead author

  
• p53-dependent hyperthermic enhancement of tumour growth inhibition by X-ray or carbon-ion beam irradiation

  A Takahashi; Ota, I; T Tamamoto; Asakawa, I; Y Nagata; H Nakagawa; N Kondo; K Ohnishi; Y Furusawa; H Matsumoto; T Ohnishi

  INTERNATIONAL JOURNAL OF HYPERTHERMIA, 2003, Peer-reviewed

  
• Radiation-induced apoptosis in SCID mice spleen after low dose irradiation

  A Takahashi; N Kondo; H Inaba; K Uotani; Y Kiyohara; K Ohnishi; T Ohnishi

  SPACE LIFE SCIENCES: BIODOSIMETRY, BIOMARKERS AND LATE STOCHASTIC EFFECTS OF SPACE RADIATION, 2003, Peer-reviewed

  
• Radiation-induced apoptosis in the scid mouse spleen after low dose-rate irradiation

  A Takahashi; Asakawa, I; K Yuki; T Matsumoto; M Kumamoto; N Kondo; K Ohnishi; A Tachibana; T Ohnishi

  INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, Aug. 2002, Peer-reviewed

  
• Radiation response of apoptosis in C57BL/6N mouse spleen after whole-body irradiation

  A Takahashi; K Ohnishi; Asakawa, I; N Kondo; H Nakagawa; M Yonezawa; A Tachibana; H Matsumoto; T Ohnishi

  INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, Sep. 2001, Peer-reviewed

  

Misc.

• 3D Imaging of Metabolic Effects of the Brains from Murine Models of Glioma Treated with Boron Neutron Capture Therapy (BNCT)

  小林奈央; 近藤夏子; 櫻井良憲; 鈴木実; 山口真一; 池川雅哉

  質量分析総合討論会講演要旨集, 2023

  
• Biological Effects on Blood Brain Barrier Induced by Particle Irradiation

  近藤夏子; 櫻井良憲; 高田卓志; 前田宗利; 久米恭

  若狭湾エネルギー研究センター研究年報, 2021, Lead author, Corresponding author

  
• Elucidation of iPS-Derived Neuronal Cell Death and Inflammation Induced by Particle Radiation

  近藤夏子; 櫻井良憲; 高田卓志; 久米恭; 前田宗利

  若狭湾エネルギー研究センター研究年報, 2020, Lead author, Corresponding author

  
• Microdosimetry for Formation of Brain Radiation Necrosis in Particle Irradiation Field using LET Counter

  櫻井良憲; 近藤夏子; 高田卓志; 呼尚徳; 久米恭; 前田宗利

  若狭湾エネルギー研究センター研究年報, 2019

  
• 医療分野 1.粒子線がん治療高度化のための生物応答解明研究 1.5 Silicon-on-insulator microdosimeterを用いた粒子線場における脳壊死形成に関するマイクロドジメトリ

  櫻井良憲; 近藤夏子; 高田卓志; 呼尚徳; 久米恭; 前田宗利; 伊東富由美

  若狭湾エネルギー研究センター研究年報, 2018

  
• Reactor-based boron neutron capture therapy with add-on bevacizumab for recurrent malignant glioma: The final report

  古瀬元雅; 川端信司; 鰐渕昌彦; 鰐渕昌彦; 斯波宏行; 竹内孝治; 竹内孝治; 近藤夏子; 田中浩基; 櫻井良憲; 鈴木実; 小野公二; 宮武伸一; 宮武伸一

  日本脳腫瘍学会プログラム・抄録集, 2021

  
• 再発悪性神経膠腫に対する原子炉を用いたホウ素中性子捕捉療法(Boron neutron capture therapy(BNCT) for the patients with recurrent malignant glioma using nuclear reactor)

  川端 信司; 平松 亮; 松下 葉子; 藤城 高広; 古瀬 元雅; 黒岩 敏彦; 近藤 夏子; 宮武 伸一; 小野 公二

  日本癌学会総会記事, Sep. 2018

  
• Phase I study of boron neutron capture therapy (BNCT) using accelerator BNCT system for the recurrent malignant glioma

  Shinji Kawabata; Ryo Hitamatsu; Yoko Matsushita; Takahiro Fujishiro; Motomasa Furuse; Natsuko Kondo; Toshihiko Kuroiwa; Koji Ono

  CANCER SCIENCE, Jan. 2018

  
• 脳腫瘍幹細胞のBNCT(硼素中性子捕捉療法)薬剤の取り込み不均一性の解明

  近藤夏子; 疋田正喜; 中田光俊; 鈴木実

  日本脳腫瘍学会プログラム・抄録集, 2018, Lead author, Corresponding author

  
• Radio-Sensitivity of Pimonidazole -Unlabeled Intratumor Quiescent Cells to γ-Rays, Accelerated Carbon Ion Beams and Boron Neutron Capture Reaction (BNCR)

  Masunaga S; Sakurai Y; Tanaka H; Hirayama R; Matsumoto Y; Uzawa A; Tano K; Sanada Y; Suzuki M; Kondo N; Takata T; Watanabe T; Tamari Y; Maruhashi A; Ono K

  9th Young Researchers' BNCT Meeting, Nov. 2017

  
• 再発悪性神経膠腫に対する加速器中性子源を用いるホウ素中性子捕捉療法(BNCT)の第一相試験

  川端 信司; 平松 亮; 松下 葉子; 藤城 高広; 古瀬 元雅; 近藤 夏子; 黒岩 敏彦; 小野 公二

  日本癌学会総会記事, Sep. 2017

  
• LIPID ALTERATION FOLLOWING PROTON BEAM IRRADIATION IN MOUSE BRAIN OF RADIATION NECROSIS MODEL

  N. Kondo; K. Nakayama; Y. Sakurai; T. Takata; K. Kume; S. Miyatake; T. Inoue; O. Ogawa; M. Suzuki

  NEURO-ONCOLOGY, May 2017, Lead author, Corresponding author

  
• 京都大学原子炉実験所におけるホウ素中性子捕捉療法(BNCT)の臨床研究の現状と計画

  鈴木 実; 近藤 夏子; 楢林 正流; 藤本 望; 仲川 洋介; 渡邉 翼; 櫻井 良憲; 田中 浩基; 高田 卓志; 木梨 友子; 増永 慎一郎

  Japanese Journal of Radiology, Feb. 2017

  
• 骨軟部悪性腫瘍に対するホウ素中性子捕捉療法(BNCT)

  鈴木 実; 近藤 夏子; 楢林 正流; 藤本 望; 仲川 洋介; 櫻井 良憲; 田中 浩基; 高田 卓志; 木梨 友子; 増永 慎一郎; 藤本 卓也; 市川 秀喜; 安藤 徹

  Japanese Journal of Radiology, Feb. 2017

  
• 治療生物学的および放射線腫瘍学的視点から見たホウ素中性子捕捉療法の特性

  増永慎一郎; 櫻井良憲; 鈴木実; 田中浩基; 田野恵三; 近藤夏子; 渡邉翼; 真田悠生; 高田卓志; 玉利勇樹; 丸橋晃; 小野公二

  第19回癌治療増感研究シンポジウム, Feb. 2017

  
• Boron neutron capture therapy for multiple liver metastasis: A case report

  M.Suzuki; T.Watanabe; N.Kondo; M.Narabayashi; Y.Kinashi; S.Masunaga; T.Takata; N.Fujimoto; H.Tanaka; Y.Sakurai; K.Ono

  The 17th International Congress on Neutoron Capture Therapy, Oct. 2016

  
• CBE factors for boron compounds to the tumor varies depending on their 10B levels-radiobiological consideration about its significance-

  Koji Ono; Shin-Ichiro Masunaga; Tsubasa Watanabe; Minoru Suzuki; Natsuko Kondo; Yuko Kinashi

  The 17th International Congress on Neutron Caputure Therapy, Oct. 2016

  
• 多発肝転移腫瘍に対してホウ素中性子捕捉療法を施行した1例

  鈴木 実; 渡邉 翼; 近藤 夏子; 楢林 正流; 木梨 友子; 増永 慎一郎; 高田 卓志; 藤本 望; 田中 浩基; 櫻井 良憲; 丸橋 晃; 小野 公二

  日本癌治療学会学術集会抄録集, Oct. 2016

  
• 抗腫瘍効果から見た中性子捕捉療法の治療生物学的解釈

  増永慎一郎; 櫻井良憲; 鈴木 実; 田中浩基; 丸橋 晃; 田野恵三; 真田悠生; 近藤夏子; 渡邉 翼; 高田卓志; 小野公二

  第45回放射線による制癌シンポジウム, Jul. 2016, Invited

  
• 悪性胸膜中皮腫に対するホウ素中性子捕捉療法

  鈴木 実; 櫻井 良憲; 仲川 洋介; 楢林 正流; 近藤 夏子; 木梨 友子; 増永 慎一郎; 渡邉 翼; 藤本 望; 田中 浩基; 丸橋 晃; 山本 由佳; 吉永 尚生; 岡本 賢一; 栗原 孝太; 小野 公二

  Japanese Journal of Radiology, Feb. 2016

  
• The effect of fractionated administration of thalidomide at γ-ray irradiation on tumor response and lung metastasis

  S. Masunaga; K. Tano; Y. Sanada; Y. Sakurai; H. Tanaka; M. Suzuki; N. Kondo; M. Narabayashi; T. Watanabe; Y. Nakagawa; A. Maruhashi; K. Ono

  the International Conference on Translational Research in Radiation Oncology-Physics for Health in Europe 2016, Feb. 2016, Peer-reviewed

  
• 再発悪性神経膠腫に対するBNCT 原子炉から加速器へ

  宮武伸一; 川端信司; 黒岩敏彦; 鈴木実; 近藤夏子; 小野公二; 成田善孝; 後藤博美; 廣瀬勝己; 高井良尋

  日本脳腫瘍の外科学会プログラム・抄録集, 2016

  
• BNCTによる悪性グリオーマの局所制御の結果顕在化した脳脊髄液播種の病理解析

  近藤夏子; BARTH Rolf F; 宮武伸一; 宮武伸一; 川端信司; 鈴木実; 小野公二; LEHMAN Norman L

  日本脳腫瘍学会プログラム・抄録集, 2016

  
• 脳腫瘍BNCTのための生物学的基礎研究―脳壊死モデル作成と腫瘍幹細胞に関する研究―

  近藤夏子; 櫻井良憲; 高田卓志; 鈴木実; 仲川洋介; 田中浩基; 藤本望; 渡邊翼; 増永慎一郎; 小野公二; 久米恭; 宮武伸一; 川端信司; 高井伸彦; 木村寛之; BARTH Rolf; LEHMAN Norm; 中野伊知郎

  KURRI-EKR (Web), Jan. 2016

  
• ボーラスを用いた髄膜腫BNCTにおける線量分布改善に関する一考察

  櫻井良憲; 田中浩基; 高田卓志; 藤本望; 近藤夏子; 仲川洋介; 楢林正流; 渡邉翼; 木梨友子; 増永慎一郎; 鈴木実; 川端信司; 宮武伸一; 小野公二; 丸橋晃

  第12回日本中性子捕捉療法学会学術大会, Sep. 2015

  
• ホウ素中性子捕捉療法における均一な熱中性子場形成に関する研究

  藤本望; 田中浩基; 櫻井良憲; 高田卓志; 近藤夏子; 楢林正流; 仲川洋介; 渡邉翼; 木梨 友子; 増永慎一郎; 丸橋晃; 小野公二; 鈴木実

  第12回日本中性子捕捉療法学会学術大会, Sep. 2015

  
• 悪性胸膜中皮腫に対する第1相ホウ素中性子捕捉療法の新プロトコールに関する考案

  鈴木実; 櫻井良憲; 小野公二; 渡邉翼; 仲川洋介; 近藤夏子; 藤本望; 高田卓志; 田中浩基; 木梨友子; 増永慎一郎; 丸橋晃

  第12回日本中性子捕捉療法学会学術大会, Sep. 2015

  
• Radiation necrosis model in mouse brain following dose escalation

  N. Kondo; Y. Sakurai; T. Takata; Y. Nakagawa; H. Tanaka; T. Watanabe; K. Kume; N. Takai; S. Miyatake; S. Masunaga; M. Suzuki; K. Ono

  8th Young Researchers BNCT Meeting, Sep. 2015, Lead author, Corresponding author

  
• A study on improvement of dose distribution using bolus in BNCT for head and neck tumors

  Y. Sakurai; H. Tanaka; T. Takata; N. Fujimoto; N. Kondo; Y. Nakagawa; T. Watanabe; M. Narabayashi; Y. Kinashi; S. Masunaga; M. Suzuki; K. Ono; A. Maruhashi

  8th Young Researchers BNCT Meeting, Sep. 2015

  
• A study on improvement method of dose distribution using bolus in boron neutron capture therapy for head and neck tumors

  Yoshinori Sakurai; Hiroki Tanaka; Takushi Takata; Nozomi Fujimoto; Natsuko Kondo; Yosuke Nakagawa; Tsubasa Watanabe; Masaru Narabayashi; Yuko Kinashi; Shinichiro Masunaga; Minoru Suzuki; Koji Ono; Akira Maruhashi

  2015 World Congress on Medical Physics and Biomedical Engineering, Jun. 2015

  
• Significance of Fractionated Thalidomide Administration Combined with y-Ray Irradiation from the Viewpoint of Local Tumor Response and Lung Metastasis

  Masunaga S; Sanada Y; Moriwaki T; Tano K; Sakurai Y; Tanaka H; Suzuki M; Kondo N; Narabayashi M; Watanabe T; Nakagawa Y; Maruhashi A; Ono K

  Progress Report 2014, The Research Reactor Institute, Kyoto University, 2015

  
• Boron Neutron Capture Therapy for Radiation-induced Osteosarcoma from the Skull

  Miyatake S; Kawabata S; Hiramatsu R; Futamura G; Kuroiwa T; Sakurai Y; Tanaka H; Maruhashi A; Suzuki M; Kondo N; Masunaga S; Kinashi Y; Ono K

  Progress Report 2014, The Research Reactor Institute, Kyoto University, 2015

  
• 悪性神経膠腫の治療におけるベバシズマブの功罪

  宮武伸一; 野々口直助; 古瀬元雅; 川端信司; 黒岩敏彦; 近藤夏子; 鈴木実; 小野公二

  日本脳腫瘍学会プログラム・抄録集, 2015

  
• The dependency of CBE factors on the concentration of administered neutron capture agents in BNCT

  Masunaga S; Sakurai Y; Tanaka H; Tano K; Suzuki M; Kondo N; Narabayashi M; Watanabe T; Nakagawa Y; Maruhashi A; Ono K

  The 2nd KURRI International Workshop on BNCT, Dec. 2014

  
• Development of real time neutron monitors for BNCT

  Tanaka H; Sakurai Y; Suzuki M; Masunaga S; Kinashi Y; Taki K; Fujii T; Fujimoto N; Takata T; Watanabe T; Nakagawa Y; Narabayashi M; Kondo N; Maruhashi A; Ono K

  The 2nd KURRI International Workshop on BNCT, Dec. 2014

  
• 硼素中性子捕捉療法に組み合わされたベバシズマブ投与併用の意義

  増永慎一郎; 櫻井良憲; 田中浩基; 田野恵三; 鈴木 実; 近藤夏子; 楢林正流; 渡邉 翼; 仲川洋介; 丸橋 晃; 小野公二

  日本放射線腫瘍学会 第27回学術大会 O-318 (2014.12.11-13) 横浜, Dec. 2014

  
• The past, present, and future of the reactor-based neutron source at Kyoto University Reactor

  Y.Sakurai; H.Tanaka; T.Takata; N.Fujimoto; M.Suzuki; S.Masunaga; Y.Kinashi; N.Kondo; M.Narabayashi; Y.Nakagawa; T.Watanabe; K.Ono; A.Maruhashi

  The 2nd International Workshop on BNCT, (2014.12.09-10) Kyoto, Dec. 2014

  
• A remodeling study of the reactor-based irradiation facility for boron neutron capture therapy at Kyoto University Research Reactort Institute

  Sakurai Y; Takata T; Tanaka H; Fujimoto N; Kondo N; Nakagawa Y; Watanabe T; Narabayashi M; Kinashi Y; Suzuki M; Masunaga S; Ono K; Maruhashi A

  14th Asia-Oceania Congress of Medical Physics & 12th South East Asia Congress of Medical Physics (AOCMP/SEACOMP 2014), Oct. 2014, Peer-reviewed

  
• 粒子線治療生物学の進展をめざして 治療生物学的解析から見た硼素中性子捕捉療法(BNCT)の特性

  増永 慎一郎; 田野 恵三; 櫻井 良憲; 田中 浩基; 鈴木 実; 近藤 夏子; 真田 悠生; 森脇 隆仁; 楢林 正流; 渡邉 翼; 仲川 洋介; 丸橋 晃; 小野 公二

  日本放射線影響学会大会講演要旨集, Sep. 2014

  
• 微小シンチレータと石英ファイバーを用いた中性子モニターのBNCT照射場への適応

  田中浩基; 櫻井良憲; 鈴木 実; 増永慎一郎; 高田卓志; 藤本 望; 渡邉 翼; 仲川洋介; 近藤夏子; 滝 和也; 木梨友子; 楢林正流; 丸橋 晃; 小野公二

  日本中性子捕捉療法学会 第11回学術大会 一般演題38 (2014.07.05-06) 吹田, Jul. 2014

  
• 生体高分子をキャリアとしたホウ素デリバリーシステム：マレイミドドデカボレート(MID)の開発と生物活性評価

  中村浩之; 加納大輔; 立川将士; 佐藤伸一; 近藤夏子; 鈴木 実; 櫻井良憲; 小野公二

  日本中性子捕捉療法学会 第11回学術大会 一般演題30 (2014.07.05-06) 吹田, Jul. 2014

  
• ボーラスを用いた頭頸部BNCTにおける線量分布改善手法に関する一検討

  櫻井良憲; 田中浩基; 高田卓志; 藤本 望; 近藤夏子; 仲川洋介; 渡邉 翼; 楢林正流; 木梨友子; 増永慎一郎; 鈴木 実; 小野公二; 丸橋 晃

  日本中性子捕捉療法学会 第11回学術大会 一般演題19 (2014.07.05-06) 吹田, Jul. 2014

  
• 再発悪性神経膠腫に対するホウ素中性子捕捉療法の臨床成績

  川端信司; 二村 元; 平松 亮; 松下葉子; 古瀬元雅; 野々口直助; 黒岩敏彦; 田中浩基; 櫻井良憲; 近藤夏子; 鈴木 実; 小野公二; 宮武伸一

  日本中性子捕捉療法学会 第11回学術大会 一般演題01 (2014.07.05-06) 吹田, Jul. 2014

  
• 一般外科領域における中性子捕捉療法の臨床経験と今後の展望

  柳衛宏宣; 野中泰政; 波多江 亮; 丸山正二; 黒山信一; 大野烈士; 小山和行; 東 秀史; 瀬口浩司; 生嶋一朗; 鈴木 実; 増永慎一郎; 木梨友子; 櫻井良憲; 田中浩基; 近藤夏子; 楢林正流; 丸橋 晃; 小野公二; 高橋浩之; 江里口正純

  日本中性子捕捉療法学会 第11回学術大会 WS3-3 (2014.07.05-06) 吹田, Jul. 2014

  
• Experiences of BNCT and start of world first clinical trial by small cyclotron neutron irradiation system in KURRI

  Hiroki Tanaka; Yoshinori Sakurai; Minoru Suzuki; Shin-ichiro Masunaga; Yuko Kinashi; Natsuko Kondo; Masaru Narabayashi; Takushi Takata; Nozomi Fujimoto; Tsubasa Wawatanabe; Yosuke Nakagawa; Akira Maruhashi; Koji Ono

  Annual National Conference on Prospect of Science and Technology Accelerator for Health, Industry and Environment, Jun. 2014, Invited

  
• Significance of Combined Treatment with Bevacizumab in Boron Neutron Capture Therapy in Terms of Local Tumor Response and Lung Metastasis

  Masunaga S; Sakurai Y; Tano K; Tanaka H; Suzuki M; Kondo N; NarabayashiM; Watanabe T; Nakagawa Y; Maruhashi A; Ono K

  the 16th International Congress of Neutron Capture Theray, Jun. 2014, Peer-reviewed

  Access this misc :

  
• Development of radiation-quality -evaluation phantom for BNCT

  Y.Sakurai; H.Tanaka; N.Fujimoto; N.Kondo; Y.Nakagawa; T.Watanabe; M.Suzuki; K.Ono; A.Maruhashi

  日本医学物理学会 第107回学術大会O-170 (2014.04.10-13) 横浜, Apr. 2014

  
• Clinical Study on Boron Neutron Capture Therapy (BNCT)

  Suzuki M; Masunaga S; Ono K; Kondo N; Narabayashi M; Kinashi Y; Sakurai Y; Tanaka H; Maruhashi A; Ishikawa M

  Progress Report 2013, The Research Reactor Institute, Kyoto University, 2014

  
• A Case Report: Current Status of GBM 33Mo after BNCT

  Takagaki M; Tachizawa T; Tanaka H; Sakurai Y; Suzuki M; Maruhashi A; Kondo N; Masunaga S; Ono K

  Progress Report 2013, The Research Reactor Institute, Kyoto University, 2014

  
• Boron Neutron Capture Therapy with Bevacizumab May Prolong the Survival of Recurrent Malignant Glioma Patients

  Miyatake S; Kawabata S; Hiramatsu R; Futamura G; Kuroiwa T; Sakurai Y; Tanaka H; Maruhashi A; Suzuki M; Kondo N; Masunaga S; Kinashi Y; Ono K

  Progress Report 2013, The Research Reactor Institute, Kyoto University, 2014

  
• Dependency of Compound Biological Effectiveness (CBE) Factors on the Type and Concentration of Administered Neutron Capture Agents in BNCT

  MASUNAGA Shin-ichiroMasunaga S; Tano K; Sanada Y; Moriwaki T; Sakurai Y; Tanaka H; Suzuki M; Kondo N; Narabayashi M; Nakagawa Y; Watanabe T; Maruhashi A; Ono K

  Progress Report 2013, The Research Reactor Institute, Kyoto University, 2014

  
• 新規含ホウ素化合物の設計・合成とBNCTおよびホウ素NMRの試み

  青木伸; 田中智博; 荒木力太; 西浦由紀子; 津本泰宏; 久松洋介; 鈴木利宙; 堀江和峰; 西道隆巨; 小野公二; 樫井良憲; 増永慎一郎; 近藤夏子; 福井真澄; 安部良

  京都大学原子炉実験所第48回学術講演会報文集, Jan. 2014

  
• BNCTの免疫系への影響に関する基礎検討

  堀江和峰; 鈴木利宙; 月本光俊; 森夏樹; 西野圭祐; 樫井良憲; 増永慎一郎; 近藤夏子; 福井真澄; 小野公二; 青木伸; 安部良

  京都大学原子炉実験所第48回学術講演会報文集, Jan. 2014

  
• ホウ素中性子捕捉療法のための加速器中性子源

  田中浩基; 樫井良憲; 藤本望; 鈴木実; 増永慎一郎; 木梨友子; 渡遺翼; 近藤夏子; 楢林正流; 仲川洋介; 丸橋晃; 小野公二

  京都大学原子炉実験所第48回学術講演会報文集, Jan. 2014

  
• 再発悪性神経膠腫に対するBNCTとbevacizumabの同時併用療法は新規治療法になるか?

  宮武伸一; 川端信司; 野々口直助; 古瀬元雅; 二村元; 黒岩敏彦; 近藤夏子; 鈴木実; 道上宏之; 小野公二

  日本脳腫瘍学会プログラム・抄録集, 2014

  
• 新規ホウ素投薬プロトコールによる再発悪性神経膠腫に対するBNCTの臨床試験

  川端信司; 宮武伸一; 平松亮; 二村元; 松下葉子; 野々口直助; 古瀬元雅; 黒岩敏彦; 田中浩基; 櫻井良憲; 近藤夏子; 鈴木実; 小野公二

  日本脳腫瘍学会プログラム・抄録集, 2014

  
• 中皮腫BNCTにおける照射門数に関する一考察

  櫻井良憲; 田中浩基; 鈴木 実増永慎一郎; 木梨友子; 近藤夏子; 楢林正流; 丸橋 晃; 小野公二

  日本放射線腫瘍学会 第26回学術大会 O-268 (2013.10.18-20) 青森, Oct. 2013

  
• 局所腫瘍効果と肺転移能抑制能から見た分割ウォルトマニン投与併用γ線照射の有用性

  増永慎一郎; 田野恵三; 櫻井良憲; 田中浩基; 鈴木実; 近藤夏子; 楢林正流; 渡邉翼; 丸橋晃; 小野公二

  日本放射線腫瘍学会第26回学術大会, Oct. 2013, Peer-reviewed

  
• ピモニダゾール非標識酸素化休止期腫瘍細胞分画における放射線損傷からの回復をウォルトマニンは効率よく抑制する

  増永慎一郎; 田野恵三; 櫻井良憲; 田中浩基; 鈴木実; 近藤夏子; 楢林正流; 渡邉翼; 木梨友子; 丸橋晃; 小野公二

  日本放射線影響学会第56回大会, Oct. 2013, Peer-reviewed

  
• 悪性脳腫瘍克服へ向けたホウ素中性子捕捉療法の試み(Boron neutron capture therapy as a treatment modality for malignant brain tumors)

  川端 信司; 平松 亮; 古瀬 元雅; 松下 葉子; 宮武 伸一; 黒岩 敏彦; 鈴木 実; 増永 慎一郎; 近藤 夏子; 小野 公二

  日本癌学会総会記事, Oct. 2013

  
• 直腸癌骨盤内再発腫瘍に対する中性子捕捉療法の臨床経験

  柳衛宏宣; 野中泰政; 波多江 亮; 丸山正二; 大野烈士; 鈴木 実; 増永慎一郎; 木梨友子; 櫻井良憲; 田中浩基; 近藤夏子; 楢林正流; 丸橋 晃; 小野公二; 江里口正純

  日本中性子捕捉療法学会 第10回学術大会 一般演題45 (2013.09.07-08) 岡山, Sep. 2013

  
• 安全かつ効果的なBNCTへの取り組み看護師による治療前オリエンテーションの導入と成果

  山本由佳; 鈴木 実; 小野公二; 増永慎一郎; 木梨友子; 近藤夏子; 楢林正流; 丸橋 晃; 櫻井良憲; 田中浩基; 吉永尚生; 岡本賢一; 栗原孝太; 藤本 望; 渡邉 翼

  日本中性子捕捉療法学会 第10回学術大会 一般演題40 (2013.09.07-08) 岡山, Sep. 2013

  
• 新規診断悪性神経膠腫に対するBNCTの治療成績と多施設共同研究の近況報告

  川端信司; 平松 亮; 二村 元; 弘田祐己; 古瀬元雅; 松下葉子; 黒岩敏彦; 近藤夏子; 鈴木 実; 小野公二; 田中浩基; 櫻井良憲; 切畑光統; 宮武伸一

  日本中性子捕捉療法学会 第10回学術大会 一般演題24 (2013.09.07-08) 岡山, Sep. 2013

  
• 硼素線量評価に関する一考察

  櫻井良憲; 田中浩基; 鈴木 実; 増永慎一郎; 木梨友子; 近藤夏子; 楢林正流; 藤本 望; 渡邉 翼; 丸橋 晃; 小野公二

  日本中性子捕捉療法学会 第10回学術大会 一般演題08 (2013.09.07-08) 岡山, Sep. 2013

  
• ホウ素中性子捕捉療法における多門照射による線量分布改善に関する研究

  藤本 望; 田中浩基; 櫻井良憲; 近藤夏子; 楢林正流; 渡邉 翼; 木梨友子; 増永慎一郎; 丸橋 晃; 小野公二; 鈴木 実

  日本中性子捕捉療法学会 第10回学術大会 一般演題07 (2013.09.07-08) 岡山, Sep. 2013

  
• BNCTのための陽子線による即発ガンマ線分析法を用いたホウ素濃度測定に関する研究

  田中浩基; 櫻井良憲; 内田良平; 川村徳寛; 鈴木 実; 増永慎一郎; 土田秀次; 木梨友子; 近藤夏子; 楢林正流; 藤本 望; 渡邉 翼; 丸橋 晃; 小野公二

  日本中性子捕捉療法学会 第10回学術大会 一般演題06 (2013.09.07-08) 岡山, Sep. 2013

  
• BNCT橋渡し研究の加速的推進―BNCT Translational Research加速ネットワークの構築―

  鈴木 実; 渡邉 翼; 楢林正流; 近藤夏子; 藤本 望; 田中浩基; 木梨友子; 増永慎一郎; 櫻井良憲; 丸橋 晃; 小野公二

  日本中性子捕捉療法学会 第10回学術大会 一般演題S2-2 (2013.09.07-08) 岡山, Sep. 2013

  
• Significance of daily fractionated administration of wortmannin combined with gamma-ray irradiation in terms of local tumor response and lung metastatic potential

  Masunaga S; Sakurai Y; Tanaka H; Suzuki M; Kondo N; Narabayashi M; Maruhashi A; Ono K

  International Journal of Radiation Oncology Biology Physics, Sep. 2013, Peer-reviewed

  
• 中性子捕捉療法における加速器中性子源の現状・展望回放射線による制癌シンポジウム

  田中浩基; 櫻井良憲; 鈴木 実; 増永慎一郎; 木梨友子; 近藤夏子; 楢林正流; 密本俊典; 丸橋 晃; 小野公二

  第42回放射線による制癌シンポジウム, Jul. 2013, Invited

  
• 中性子捕捉療法における加速器中性子源の現状・展望

  田中浩基; 櫻井良憲; 鈴木 実; 増永慎一郎; 木梨友子; 近藤夏子; 楢林正流; 密本俊典; 丸橋 晃; 小野公二

  第42回放射線による制癌シンポジウム，(2013.07.05) 仙台, Jul. 2013

  
• ホウ素中性子捕捉療法 (Boron Neutron Capture Therapy, BNCT) の過去・現在と近未来

  小野公二; 鈴木 実; 近藤夏子; 楢林正流; 増永慎一郎; 木梨友子; 藤本 望; 田中浩基; 櫻井良憲; 丸橋 晃; 渡邉 翼; 宮武伸一; 平塚純一; 切畑光統

  第42回放射線による制癌シンポジウム，(2013.07.05) 仙台, Jul. 2013

  
• 中性子捕捉療法(BNCT)における腫瘍内低酸素の意義

  増永慎一郎; 田野恵三; 櫻井良憲; 田中浩基; 鈴木 実; 近藤夏子; 楢林正流; 渡邉 翼; 丸橋 晃; 小野公二

  第42回放射線による制癌シンポジウム，(2013.07.05) 仙台, Jul. 2013

  
• Development of a neutron dosimeter using LiCaAlF6 scintillator coupled with quartz optical fiber

  Hiroki Tanaka; Yoshinori Sakurai; Minoru Suzuki; Shinichiro Masunaga; Kentaro Fukuda; Yuko Kinashi; Natsuko Kondo; Masaru Narabayashi; Akira Maruhashi; Koji Ono

  The 3rd Asian Congress of Radiation Research, May 2013

  
• 再発進行頭頸部癌に対するホウ素中性子捕捉療法の経験

  太田 一郎; 鈴木 実; 近藤 夏子; 伊藤 妙子; 三上 慎司; 岡本 英之; 山中 敏彰; 櫻井 良憲; 楢林 正流; 田中 浩基; 丸橋 晃; 増永 慎一郎; 長谷川 正俊; 小野 公二; 細井 裕司

  頭頸部癌, May 2013

  
• 局所腫瘍制御と肺転移抑制能から見た低酸素細胞毒連続投与と低温度温熱処置併用放射線照射の意義

  増永慎一郎; 櫻井良憲; 田中浩基; 鈴木 実; 近藤夏子; 楢林正流; 丸橋 晃; 小野公二

  日本医学放射線学会 第72回総会C206 (2013.04.11-14) 横浜, Apr. 2013

  
• 胸膜播種および胸膜多発腫瘍に対するホウ素中性子捕捉療法

  鈴木 実; 増永 慎一郎; 楢林 正流; 近藤 夏子; 木梨 友子; 櫻井 良憲; 田中 浩基; 丸橋 晃; 小野 公二

  日本医学放射線学会学術集会抄録集, Feb. 2013

  
• Effect of Tirapazamine and Mild Temperature Hyperthermia on the Recovery from Radiation-Induced Damage in Pimonidazole-Unlabeled Quiesent Tumor Cells

  Masunaga S; Tanaka H; Sakurai Y; Suzuki M; Tano K; Kondo N; Narabayashi M; Maruhashi A; Ono K

  Progress Report 2012, The Research Reactor Institute, Kyoto University, 2013

  
• A Brain Radiation Necrosis Model in Laboratory Animals

  Miyata T; Thoho T; Yoritsune E; Furuse M; Kuroiwa T; Masunaga S; Tanaka H; Kondo N; Maruhashi A; Ono K; Miyatake S

  Progress Report 2012, The Research Reactor Institute, Kyoto University, 2013

  
• Study on the Semiconductor Device error Irradiated with Thermal Neutrons

  Tanaka H; Sakurai Y; Hori J; Suzuki M; Masunaga S; Kondo N; Narabayashi M; Kinashi Y; Ono K; Maruhashi A

  Progress Report 2012, The Research Reactor Institute, Kyoto University, 2013

  
• Combined Tretament with Continuous Administration of Tirapazamine and Mild Temperature Hyperthermia in γ-Ray Irradiation in Terms of Local Tumor Response and Lung Metastatic Potential

  Masunaga S; Sakurai Y; Tanaka H; Tano K; Suzuki M; Kondo N; Narabayashi M; Maruhashi A; Ono K

  Progress Report 2012, The Research Reactor Institute, Kyoto University, 2013

  
• ホウ素中性子捕捉療法による悪性神経膠腫の予後不良因子打開の可能性

  川端信司; 平松亮; 古瀬元雅; 黒岩敏彦; 近藤夏子; 櫻井良憲; 田中浩基; 鈴木実; 小野公二; 宮武伸一

  日本脳腫瘍学会プログラム・抄録集, 2013

  
• 放射線治療後の再発悪性神経膠腫に対する原子炉中性子源ホウ素中性子捕捉療法(BNCT)の治療成績~そして加速器BNCT治療へ

  平松亮; 川端信司; 古瀬元雅; 黒岩敏彦; 近藤夏子; 鈴木実; 小野公二; 宮武伸一

  日本脳腫瘍の外科学会プログラム・抄録集, 2013

  
• 局所腫瘍制御と肺転移抑制能から見た低酸素細胞毒(Tirapazamine)の連続投与と低温度温熱処置を併用する放射線照射の有用性について

  増永慎一郎; 櫻井良憲; 田中浩基; 鈴木実; 近藤夏子; 楢林正流; 丸橋晃; 小野公二

  第15回癌治療増感研究シンポジウム, 2013

  
• Significance of manipulating intratumor hypoxia in terms of local tumor control and pulmonary metastatic potential in boron neutron capture therapy.

  Masunaga S; Sakurai Y; Tanaka H; Suzuki M; Kondo N; Kinashi Y; Maruhashi A; Ono K

  Presented at the 2013 Annual Meeting of the American Roentgen Ray Society, 2013

  
• ピモニダゾール非標識酸素化休止期腫瘍細胞分画における放射線損傷からの回復に対するティラパザミン処置，低温度温熱処置の影響

  増永慎一郎; 田野恵三; 鈴木実; 近藤夏子; 楢林正流; 渡邉翼; 小野公二

  日本ハイパーサーミア学会第30回大会, 2013

  
• ホウ素中性子捕捉療法

  小野公二; 鈴木実; 増永慎一郎; 近藤夏子; 櫻井良憲; 田中浩基; 木梨友子; 丸橋晃

  Radioisotopes, Dec. 2012

  
• γ線、加速炭素イオン線、中性子捕捉反応に対する酸素化休止期腫瘍細胞の感受性解析

  増永慎一郎; 櫻井良憲; 田中浩基; 平山亮一; 松本孔貴; 鵜澤玲子; 鈴木 実; 近藤夏子; 丸橋 晃; 小野公二

  日本放射線腫瘍学会 第25回学術大会 O-157 (2012.11.23-25) 東京, Nov. 2012

  
• Radio-sensitivity Of Pimonidazole-unlabeled Intratumor Quiescent Cells To Gamma-rays, Accelerated Carbon Ion Beams And Boron Neutron Capture Reaction.

  Masunaga S; Sakurai Y; Tanaka H; Hirayama R; Matsumoto Y; Uzawa A; Suzuki M; Kondo N; Maruhashi A; Ono K

  Presented at the 54th Annual Meeting of the American Society for Therapeutic Radiology and Oncology (ASTRO), 28 Oct. 2012

  
• Significance of employing boron-10 carriers and manipulating intratumor oxygenation status in terms of local tumor response and lung metastatic potential in boron neutron capture therapy

  S.Masunaga; Y.Sakurai; H.Tanaka; M.Suzuki; N.Kondo; M.Narabayashi; A.Maruhashi; K.Ono

  15th International Congress on Neutron Capture Therapy, Oral Session 4B Biology 05 (2012.09.10-14) Tsukuba, Sep. 2012

  
• Multi-linked BSH fused cell-penetrating peptide (multi-BSH-peptide) accelerated boron neutron capture therapy

  H.Michiue; A.Mori; N.Kondo; F.Bin; Y.Sakurai; S.Kawabata; S.Miyatake; K.Tomizawa; K.Ono; H.Matsui

  15th International Congress on Neutron Capture Therapy, Plenary Biology 01 (2012.09.10-14) Tsukuba, Sep. 2012

  
• γ線、加速炭素イオン線、中性子捕捉反応に対する酸素化休止期腫瘍細胞の放射線感受性

  増永 慎一郎; 櫻井 良憲; 田中 浩基; 平山 亮一; 松本 孔貴; 鵜澤 玲子; 鈴木 実; 近藤 夏子; 楢林 正流; 小野 公二

  日本放射線影響学会大会講演要旨集, Sep. 2012

  
• Present status of medical physics and engineering for reactor-based BNCT in KURRI 2012

  Y.Sakurai; H.Tanaka; M.Suzuki; S.Masunaga; Y.Kinashi; N.Kondo; H.Yoshinaga; K.Okamoto; Y.Yamamoto; K.Ono; A.Maruhashi

  3rd BNCT Trilateral Meeting (2012.6.1-2) Kumatori, Jun. 2012

  
• Present status and future plans of boron neutron capture therapy at Kyoto University Research Reactor Institute

  Y.Sakurai; H.Tanaka; M.Suzuki; S.Masunaga; Y.Kinashi; N.Kondo; K.Ono; A.Maruhashi

  World Congress on Medical Physics and Biomedical Engineering (WC2012), TH.01/08.1-1 (2012.05.26-31) Beijing, May 2012

  
• 燃料低濃縮化後のKUR重水中性子照射設備の照射特性

  櫻井良憲; 田中浩基; 鈴木 実; 増永慎一郎; 木梨友子; 近藤夏子; 小野公二; 丸橋 晃

  京都大学原子炉実験所第46回学術講演会報文集, Jan. 2012

  
• High LET-radiation can overcome radioresistance of glioma stem-like cells which are radioresistant to low LET-radiation

  Hirota Y; Masunaga S; Kondo N; Kawabata S; Fujimori A; Ono K; Kuroiwa T; Miyatake S

  Progress Report 2011, The Research Reactor Institute, Kyoto University, 2012

  
• Radiosensistivity and capacity to recover from radiation-induced damage in oxygenated intratumor quiescent cell population depend on p53 status

  Masunaga S; Sakurai Y; Tanaka H; Suzuki M; Kondo N; Narabayashi M; Maruhashi A; Ono K

  Progress Report 2011, The Research Reactor Institute, Kyoto University, 2012

  
• 放射線治療後再発肺癌症例に対する硼素中性子捕捉療法

  鈴木実; 近藤夏子; 木梨友子; 増永慎一郎; 田中浩基; 櫻井良憲; 丸橋晃; 鈴木修; 西山謹司; 小野公二

  第71回日本医学放射線学会総会, 2012

  
• 局所腫瘍制御と肺転移能抑制の点からみた中性子捕捉療法における腫瘍内酸素化状況修飾の意義

  増永慎一郎; 櫻井良憲; 田中浩基; 鈴木実; 近藤夏子; 丸橋晃; 小野公二

  第71回日本医学放射線学会総会, 2012

  
• Reirradiation for locally recurrent lung cancer in the chest wall with boron neutron capture therapy (BNCT): A case report.

  Suzuki M; Suzuki O; Sakurai Y; Tanaka H; Kondo N; Kinashi Y; Masunaga S; Maruhashi A; Ono K

  Presented at the 15th International Congress on Neutron Capture Therapy, 2012

  
• High LET-irradiation can overcome radioresistance of glioma stem-like cells which are radioresistanct with low LET-irradiation.

  Hirota Y; Masunaga S; Kondo N; Kawabata S; Kuroiwa T; Fujimori A; Ono K; Miyatake S

  Presented at the 15th International Congress on Neutron Capture Therapy, 2012

  
• Dose estimation for internal organs in body-trunk BNCT.

  Sakurai Y; Tanaka H; Suzuki M; Masunaga S; Kinasi Y; Kondo N; Ono K; Maruhashi A

  Presented at the 15th International Congress on Neutron Capture Therapy, 2012

  
• Usefulness of combined treatment with continuous tirapazamine administration and mild temperature hyperthermia in gamma-ray irradiation, referring to lung metastatic potential.

  Masunaga S; Sakurai Y; Tanaka H; Suzuki M; Kondo N; Narabayashi M; Maruhashi A; Ono K

  Presented at The 11th International Congress of Hyperthermic Oncology (ICHO)\n& The 29th Japanese Congress of Thermal Medicine (JCTM), 2012

  
• 肺癌胸膜播種病変に対する硼素中性子捕捉療法

  鈴木実; 櫻井良憲; 田中浩基; 楢林正流; 近藤夏子; 木梨友子; 増永慎一郎; 井上俊彦; 丸橋晃; 小野公二

  日本放射線腫瘍学会第25回学術大会, 2012

  
• 加速器ＢＮＣＴ照射システムにおけるファントムを用いた中性子量の検証

  楢林正流; 鈴木 実; 櫻井良憲; 田中浩基; 岡本賢一; 近藤夏子; 増永慎一郎; 木梨友子; 丸橋 晃; 小野公二

  日本放射線腫瘍学会 第25回学術大会, 2012

  
• 中性子捕獲反応後組織に生じるＤＮＡ二本鎖切断のγＨ２ＡＸによる検出

  近藤夏子; 楢林正流; 鈴木 実; 木梨友子; 増永慎一郎; 櫻井良憲; 田中浩基; 大西武雄; 小野公二

  日本放射線影響学会 第55回大会, 2012

  
• 通常放射線照射および中性子捕捉療法後の局所腫瘍効果と肺転移抑制効果における腫瘍内酸素状況修飾処置併用の意義

  増永慎一郎; 松本孔貴; 平山亮一; 櫻井良憲; 田中浩基; 鵜澤玲子; 鈴木実; 近藤夏子; 丸橋晃; 小野公二

  第41 回 放射線による制癌シンポジウム?基礎と臨床の対話-, 2012

  
• 硼素中性子捕捉療法のための即発γ線測定法による硼素濃度評価下限の改善

  櫻井良憲; 田中浩基; 鈴木 実; 増永慎一郎; 木梨友子; 近藤夏子; 小野公二; 丸橋 晃

  日本医学物理学会 第103回学術大会, 2012

  
• 低酸素バイオロジー研究に基づく放射線生物学・放射線腫瘍学の新展開 局所腫瘍内低酸素領域の修飾が及ぼす遠隔肺転移能への影響 局所腫瘍制御と遠隔転移能抑制の同時達成に向けて

  増永 慎一郎; 松本 孔貴; 平山 亮一; 櫻井 良憲; 田中 浩基; 鈴木 実; 近藤 夏子; 丸橋 晃; 小野 公二

  日本放射線影響学会大会講演要旨集, Nov. 2011

  
• Significance of Using a 10B-Carrier and Manipulating Intratumor Hypoxia on Local Tumor Response and Lung Metastatic Potential in Boron Neutron Capture Therapy

  Masunaga S; Sakurai Y; Tanaka H; Suzuki M; Kondo N; Maruhashi A; Ono K

  Int J Radiat Oncol Biol Phys, Oct. 2011, Peer-reviewed

  
• Overview of cyclotron-based epithermal neutron source for boron neutron capture therapy

  H.Tanaka; Y.Sakurai; M.Suzuki; S.Masunaga; Y.Kinashi; N.Kondo; Maruhashi, K.Ono; T.Mitsumoto

  14th International Congress of Radiation Research (ICRR-14), POS09-15 (2011.08.28-09.01) Warsaw, Aug. 2011

  
• Characteristic estimation for BNCT irradiation fields ? from the viewpoint of energy transfer to biological tissues

  Y.Sakurai; H.Tanaka; M.Suzuki; S.Masunaga; Y.Kinashi; N.Kondo; K.Ono; A.Maruhashi

  14th International Congress of Radiation Research (ICRR-14), POS09-12 (2011.08.28-09.01) Warsaw, Aug. 2011

  
• 固形腫瘍へのアバスチン(Bevacizumab) 処理による急性低酸素細胞分画の低下と肺転移抑制効果

  増永慎一郎; 劉 勇; 田中浩基; 櫻井良憲; 鈴木 実; 菓子野元郎; 木梨友子; 近藤夏子; 丸橋 晃; 小野公二

  日本医学放射線学会 第70回総会C198 (2011.05.09-20) Web, May 2011

  
• Study on Thermal Neutron Detection Method Using Imaging Plate and Activation Materials for Boron Neutron Capture Therapy

  H. Tanaka; Y. Sakurai; M. Suzuki; S. Masunaga; Y. Kinashi; N. Kondo; K. Takamiya; A. Maruhashi; K. Ono

  2011International Conference on Medical Physics, Apr. 2011

  
• 二本鎖切断(DSB)修復経路を分子標的とする中性子捕捉反応効果の増感

  近藤夏子; 増永慎一郎; 鈴木実; 木梨友子; 劉 勇; ChenYi-Wei; 小野公二; 田中浩基; 櫻井良憲; 丸橋晃; 高橋昭久; 森英一郎; 長谷川正俊; 大西武雄

  京都大学原子炉実験所第45回学術講演会報文集, Jan. 2011

  
• TMZ may not be Imcompatible with BPA-based BNCT

  TachizawaT; Takagaki M; Ohyama K; Tomaru T; Masunaga S; Kondo N; Ono K

  Progress Report 2010, The Research Reactor Institute, Kyoto University, 2011

  
• Serious Radiation Necrosis after BNCT on Grade III Glioma of von Recklinghausen’s Disease – Case Report

  Ohyama K; Moritake K; Shimizu Y; Takagaki M; Tachizawa T; Tanaka H; Sakurai Y; Kinashi Y; Suzuki M; Maruhashi A; Kondo N; Masunaga S; Ono K

  Progress Report 2010, The Research Reactor Institute, Kyoto University, 2011

  
• Boron Neutron Capture Therapy for Malibnant Brain Tumors Using Epithermal Neutrons

  Miyatake S; Kawabata S; Hiramatsu R; Hirota Y; Kuroiwa T; Sakurai Y; Tanaka H; Maruhashi A; Suzuki M; Kondo N; Masunaga S; Kinashi Y; Ono K

  Progress Report 2010, The Research Reactor Institute, Kyoto University, 2011

  
• Boron Neutron Capture Therapy for Malignant Pleural Mesothelioma

  Suzuki M; Kondo N; Masunaga S; Sakurai Y; Tanaka H; Kinashi Y; Maruhashi A; Ono K

  Progress Report 2010, The Research Reactor Institute, Kyoto University, 2011

  
• Development of Thermal Neutron Flux Monitor U sing Small Scintillator Array Coupled with Quartz Fibers for Boron Neutron Capture Therapy

  Hiroki Tanaka; Yoshinori Sakurai; Minoru Suzuki; Shinichiro Masunaga; Yuko Kinashi; Natsuko Kondo; Yuji Kawabata; Takahiro Yagi; Tsuyoshi Misawa; Koji Ono; Akira Maruhashi

  2011 IEEE NUCLEAR SCIENCE SYMPOSIUM AND MEDICAL IMAGING CONFERENCE (NSS/MIC), 2011, Peer-reviewed

  
• 中性子捕捉療法によって誘導されるDNAリガーゼIV修復不能なDNA損傷

  近藤夏子; 増永慎一郎; 高橋昭久; 鈴木実; 森英一朗; 仲川洋介; 小野公二; 長谷川正俊; 大西武雄

  第70回日本癌学会学術総会, 2011

  
• 硼素中性子捕捉療法を施行した放射線治療後パンコースト腫瘍の１例

  鈴木実; 櫻井良憲; 田中浩基; 近藤夏子; 劉 勇; 木梨友子; 増永慎一郎; 丸橋晃; 小野公二

  第70回日本医学放射線学会総会, 2011

  
• アバスチン処理による固形腫瘍内急性低酸素細胞分画の低下と肺転移抑制効果について

  増永慎一郎; 劉 勇; 田中浩基; 櫻井良憲; 鈴木 実; 近藤夏子; 丸橋 晃; 小野公二

  第13回癌治療増感研究シンポジウム, 2011

  
• 二本鎖切断(DSB)修復経路を分子標的とする中性子捕捉療法の増感の検討

  近藤夏子; 増永慎一郎; 高橋昭久; 森英一朗; 鈴木実; 木梨友子; 劉勇; 長谷川正俊; 大西武雄; 小野公二

  第13回癌治療増感研究シンポジウム, 2011

  
• Updated irradiation characteristics of the BNCT facility in Kyoto University Reactor after the fuel low-enrichment

  Y.Sakurai; H.Tanaka; M.Suzuki; S.Masunaga; Y.Kinashi; N.Kondo; K.Ono; A.Maruhashi

  6th Young Researchers Boron Neutron Capture Therapy Meeting,, 2011

  
• The characteristics of 10B distribution in solid tumors in vivo following BSH or BPA administration, referring to the responses of intratumor total and quiescent cell populations and the impact on pulmonary metastatic potential

  S.Masunaga; Y.Sakurai; H.Tanaka; M.Suzuki; N.Kondo; A.Maruhashi; K.Ono

  6th Young Researchers Boron Neutron Capture Therapy Meeting,, 2011

  
• Irreparable damage for DNA ligase IV induced by BNCT

  N.Kondo; S.Masunaga; A.Takahashi; Y.Sakurai; M.Suzuki; Y.Kinashi; E.Mori; K.Ono; M.Hasegawa; T.Ohnishi

  6th Young Researchers Boron Neutron Capture Therapy Meeting,, 2011

  
• Development of cyclotron-based epithermal neutron source for boron neutron capture therapyPhysics, 2011, P-7.

  H.Tanaka; Y.Sakurai; M.Suzuki; S.Masunaga; T.Mitsumoto; Y.Kinashi; N.Kondo; A.Maruhashi; K.Ono

  6th Japan-Korean Joint Meeting on Medical Physics, 2011

  
• Present status of boron neutron capture therapy at Kyoto University Research Reactor Institute

  Y.Sakurai; H.Tanaka; M.Suzuki; S.Masunaga; Y.Kinashi; N.Kondo; K.Ono; A.Maruhashi

  18th International Conference on Medical Physics, 2011

  
• 京大原子炉実験所におけるＢＮＣＴ用サイクロトロンを用いた熱外中性子源の概要

  田中浩基; 櫻井良憲; 丸橋 晃; 鈴木 実; 増永慎一郎; 近藤夏子; 木梨友子; 小野公二; 密本俊典

  日本原子力学会2011年秋の大会, 2011

  
• 原子炉熱外中性子線ビーム照射中のＢＮＣＴ施行患者血中硼素-１０濃度に影響し得る因子の予備的解析

  増永慎一郎; 鈴木 実; 櫻井良憲; 田中浩基; 近藤夏子; 木梨友子; 丸橋 晃; 小野公二

  日本中性子捕捉療法学会 第8回学術大会, 2011

  
• ＫＵＲ−ＢＮＣＴ臨床試験の重要性 —「1日でも早い加速器の臨床的実用化に向けて」—

  鈴木 実; 近藤夏子; 木梨友子; 増永慎一郎; 吉永尚生; 山本由香; 岡本賢一; 田中浩基; 櫻井良憲; 丸橋 晃; 小野公二

  日本中性子捕捉療法学会 第8回学術大会, 2011

  
• 京大炉ＢＮＣＴ照射設備の照射特性再評価および改造検討

  櫻井良憲; 田中浩基; 吉永尚生; 鈴木 実; 増永慎一郎; 木梨友子; 近藤夏子; 岡本賢一; 小野公二; 丸橋 晃

  日本中性子捕捉療法学会 第8回学術大会, 2011

  
• 中性子捕捉療法におけるガラス線量計を用いた線量評価の基礎的検討

  田中浩基; 櫻井良憲; 鈴木 実; 増永慎一郎; 近藤夏子; 木梨友子; 丸橋 晃; 小野公二

  日本中性子捕捉療法学会 第8回学術大会, 2011

  
• 中性子捕捉療法によって生じるDNA二本鎖切断(DSB)はDSB修復経路の因子DNA ligase IVによって修復されない

  近藤夏子; 増永慎一郎; 鈴木 実; 木梨友子; 櫻井良憲; 高橋昭久; 森 英一朗; 長谷川正俊; 大西武雄; 小野公二

  日本中性子捕捉療法学会 第8回学術大会, 2011

  
• 中性子捕捉療法における低温度温熱処置など腫瘍内酸素化状況修飾の意義について

  増永慎一郎; 櫻井良憲; 田中浩基; 鈴木実; 近藤夏子; 丸橋晃; 小野公二

  日本ハイパーサーミア学会第２８回大会(シンポジウム6-5), 2011

  
• 燃料低濃縮化後の京大炉ＢＮＣＴ設備の照射特性(II)

  櫻井良憲; 田中浩基; 鈴木 実; 増永慎一郎; 木梨友子; 劉 勇; 近藤夏子; ChenYi-Wei; 小野公二; 丸橋 晃

  日本医学物理学会 第101回学術大会, 2011

  
• Significance of Using a 10B-Carrier and Manipulating Intratumor Hypoxia in terms Of Local Tumor Response and Lung Metastatic Potential in Boron Neutron Capture Therapy

  S. Masunaga; Y. Sakurai; H. Tanaka; M. Suzuki; N. Kondo; A. Maruhashi; K. Ono

  INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2011

  
• マウス悪性腫瘍組織内の血流及び硼素化合物分布における血管新生抑制剤(Avastin)の影響

  劉 勇; 鈴木実; 菓子野元郎; 増永慎一郎; Chen Yi-Wei; 木梨友子; 田中浩基; 櫻井良憲; 丸橋晃; 近藤夏子; 切畑光統; 小野公二

  日本放射線影響学会第53回大会, Oct. 2010

  
• アバスチン処理後の血管正常化腫瘍における急性低酸素細胞分画の解除と肺転移抑制効果

  増永慎一郎; 劉 勇; 櫻井良憲; 田中浩基; 菓子野元郎; 鈴木 実; 木梨友子; 近藤夏子; 丸橋 晃; 小野公二

  日本放射線腫瘍学会第23回学術大会, 2010

  
• 京都大学原子炉実験所における加速器BNCTの治療手順

  鈴木実; 田中浩基; 櫻井良憲; 劉 勇; 菓子野元郎; 木梨友子; 増永慎一郎; 近藤夏子; 岡本賢一; 小野公二; 丸橋晃

  第7回日本中性子捕捉療法学会学術大会, 2010

  
• 中性子捕捉療法を受けた脳腫瘍患者の酸化ストレスレベルと、被爆・治療線量、腫瘍効果および有害事象などとの関連性解析

  近藤夏子; 増永慎一郎; 鈴木実; 劉 勇; 陳 一; 田中浩基; 櫻井良憲; 丸橋晃; 木梨友子; 宮武伸一; 小野公二

  第7回日本中性子捕捉療法学会学術大会, 2010

  
• アルキル化剤によるDNA損傷修復メカニズムとそのがん治療への応用

  近藤夏子; 髙橋昭久; 大西武雄

  放射線生物研究, 2009

  

Presentations

• Profile of miRNAs in small extracellular vesicles released from glioblastoma cells treated by Boron Neutron Capture Therapy’

  Natsuko Kondo

  20th International Congress on Neutron Capture Therapy, 28 Jun. 2024

  
• 放射線脳壊死の発症に関連する慢性的なリゾホスファチジルコリンの上昇とミクログリアのP2X4受容体の活性化

  近藤 夏子; 櫻井 良憲; 高田 卓志; 可野 邦行; 久米 恭; 前田 宗利; 高井 伸彦; 鈴木 周五; 衛藤 史博; 菊島 健児; 鰐淵 英機; 宮武 伸一; 尾田 正二; 瀬藤 光利; 青木 淳賢; 鈴木 実

  日本放射線腫瘍学会 第５９回生物部会学術大会, 24 Jun. 2022

  
• Radiation Biology on BNCT - what we have known and don't know

  Natsuko Kondo; Minoru Suzuki; Koji Ono

  Technical Meeting on Advances in Boron Neutron Capture Therapy, International Atomic Energy Agency (IAEA), 29 Jul. 2020, Invited

  
• Boron Neutron Capture Therapy in Kyoto University - from reactor based to accelerator based-

  Natsuko Kondo

  Kyoto University-UCLA International Symposium, Nov. 2018, Invited

  
• 胸膜播種および胸膜多発腫瘍に対するホウ素中性子捕捉療法

  第72回日本医学放射線学会総会

  
• 局所腫瘍制御と肺転移抑制能から見た低酸素細胞毒連続投与と低温度温熱処置併用放射線照射の意義

  第72回日本医学放射線学会総会

  
• Multi-linked BSH fused cell-penetrating peptide (multi-BSH-peptide) accelerated boron neutron capture therapy

  15th International Congress on Neutron Capture Therapy

  
• 放射線治療後再発肺癌に対する硼素中性子捕捉療法

  日本医学放射線学会 第71回総会

  
• 局所腫瘍制御と肺転移能抑制の点から見た中性子捕捉療法における腫瘍内酸素化状況修飾の意義

  日本医学放射線学会 第71回総会

  
• FANCD1の抑制はアルキル化剤で誘導される相同組換えのRad51活性を低減する

  第29回日本脳腫瘍学会学術集会

  
• 中性子捕捉療法によって誘導されるDNA ligase IV修復不能なDNA損傷

  第70回日本癌学会学術総会

  
• 固形腫瘍へのアバスチン(Bevacizumab) 処理による急性低酸素細胞分画の低下と肺転移抑制効果

  日本医学放射線学会 第70回総会

  

Awards

• 17 Sep. 2011

  日本中性子捕捉療法学会, 第8回日本中性子捕捉療法学会学術大会ベストプレゼンテーション賞（物理分野）
• 24 Jun. 2011

  国際癌治療増感研究協会, 第12回国際癌治療増感研究協会研究奨励賞
• 16 Jun. 2017

  日本放射線腫瘍学会, 2017年 日本放射線腫瘍学会生物部会賞
• 07 Aug. 2016

  日本中性子捕捉療法学会, 第13回日本中性子捕捉療法学会学術大会ベストプレゼンテーション賞（臨床医学）

External funds: Kakenhi

• 悪性グリオーマのBNCT抵抗性の機序解明

  Grant-in-Aid for Scientific Research (C)

  Basic Section 56010:Neurosurgery-related

  Kyoto University

  近藤 夏子

  From 01 Apr. 2021, To 31 Mar. 2024, Granted

  BNCT;悪性グリオーマ;共培養;アストロサイト;ミクログリア;空間的遺伝子解析;再発

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K09151/
• Bioactive lipids involved in radiation brain necrosis

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  Natsuko Kondo

  From 01 Apr. 2017, To 31 Mar. 2020, Project Closed

  放射線脳壊死;脂質メディエーター;リゾリン脂質;ミクログリア;P2X4受容体;慢性炎症;放射線脳壊死モデル;リゾホスファチジルコリン;イメージングMS;生理活性脂質;脳腫瘍学;バイオマーカー

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K16641/
• Clinical trial of boron neutron capture therapy with the combination of successive bevacizumab treatments for recurrent malignant gliomas

  Grant-in-Aid for Scientific Research (C)

  Osaka Medical College

  Shin-Ichi MIYATAKE

  From 01 Apr. 2017, To 31 Mar. 2020, Project Closed

  BNCT;bevacizumab;再発悪性神経膠腫;放射線脳壊死;malignant glioma;RPA

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K10877/
• Accuracy improvement for dose and beam-quality estimation of irradiation field for boron neutron capture therapy using dual phantom technique

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Yoshinori Sakurai

  From 01 Apr. 2016, To 31 Mar. 2019, Project Closed

  硼素中性子捕捉療法(BNCT);高速中性子;生物学的効果比(RBE);粒子線治療;放射線計測;品質保証／品質管理(QA/QC);医学物理;放射線工学;生物学的効果比;BNCT;線量評価;RBE

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H05237/
• Analysis of pathophysiology of brain radiation necrosis and establishment of novel treatment strategy

  Grant-in-Aid for Scientific Research (B)

  Osaka Medical College

  Shin-Ichi Miyatake

  From 01 Apr. 2014, To 31 Mar. 2017, Project Closed

  脳放射線壊死;血管内皮増殖因子;ホウ素中性子捕捉療法;ベバシズマブ;HIF-1 alpha;BNCT;bevacizumab;HIF-1阻害剤;再発悪性神経膠腫;放射線脳壊死;脳神経疾患;ベﾊﾞｼｽﾞﾏﾌﾞ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26293327/
• Detection of gamma H2AX foci in mouse normal brain and brain tumor after boron neutron capture therapy

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  Natsuko Kondo

  From 01 Apr. 2013, To 31 Mar. 2016, Project Closed

  ホウ素中性子捕捉療法;DNA二本鎖切断;γH2AX;悪性グリオーマ;中性子捕捉療法;正常脳;グリオブラストーマ;脳腫瘍

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25870382/
• FANCD1 plays predominant role in the repair of DNA damage induced by ACNU or TMZ.

  Grant-in-Aid for Research Activity Start-up

  Kyoto University

  Natsuko KONDO

  From 01 Apr. 2010, To 31 Mar. 2012, Project Closed

  FANCD1;テモゾロミド(TMZ);塩酸ニムスチン(ACNU);HomologousRecombination修復経路;グリオブラストーマ;Homologous Recombination修復経路;ファンコニ貧血;DNA修復路;悪性グリオーマ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22890095/
• マクロファージ極性制御によるがん微小環境制御とBNCTへの影響に関する研究

  Grant-in-Aid for Scientific Research (B)

  Basic Section 90120:Biomaterials-related

  Osaka Metropolitan University

  長崎 健

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  がん治療;BNCT;マクロファージ;DDS

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23H03745/
• Biological and chemical dose estimation for neutrons using multiple phantom method

  Grant-in-Aid for Scientific Research (B)

  Basic Section 63020:Radiation influence-related

  Kyoto University

  櫻井 良憲

  From 01 Apr. 2024, To 31 Mar. 2027, Granted

  多重ファントム法;ホウ素中性子捕捉療法;中性子線量評価;生物学的線量;化学的線量

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K03082/
• マクロファージ極性制御によるがん微小環境制御とBNCTへの影響に関する研究

  Grant-in-Aid for Scientific Research (B)

  Basic Section 90120:Biomaterials-related

  Osaka Metropolitan University

  長崎 健

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  がん治療;ホウ素中性子捕捉療法;マクロファージ;薬物送達システム;がん微小環境;BNCT;DDS

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K28434/

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  Molecular Biophysics

  5096, Spring, Faculty of Engineering, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Molecular Biophysics

  5096, Spring, Faculty of Engineering, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Molecular Biophysics

  5096, Spring, Faculty of Engineering, 2

Part-time lecturer

• From 01 Apr. 2022, To 31 Mar. 2023

  生物物理学

  前期, 京都大学, 工学部

Academic, Social Contribution

Committee Memberships

• From Oct. 2018, To Present

  Board of Councilor (Biology), International Society for Neutron Capture Therapy