Basic Information

Academic Degree

• 修士（生命科学）(東洋大学)
• 博士（生命科学）(東洋大学)

Research History

• Toyo University, 研究助手

ID,URL

• J-Global ID

  201301007351458211

• Researcher number

  60625391

researchmap URL

• https://researchmap.jp/g0000211163

Research

Research Areas

• Life sciences, Laboratory animal science, Chicken Chorioallantoic Membrane Model
• Other, Other, Auger therapy
• Other, Other, Boron neutron capture therapy
• Nanotechnology/Materials, Nanobioscience

Papers

• Exploratory rat toxicology and efficacy of the boron neutron capture therapy drug boronotyrosine in a mouse model of head and neck cancer

  A. Raitano; W. Kilby; Ka. Morrison; L. Capo; M. Ikeura; M. Torgov; T. J. Martin; M. C. Malinao; C. Lee; K. Matsumoto; A. Komatsu; Y. Higashi; M. Suzuki; F. Tamanoi; Ke. Morrison

  International Journal of Radiation Oncology Biology Physics, Jul. 2025, Peer-reviewed

  
• Accumulation of small-size, highly dispersive mesoporous silica nanoparticles in a tumor in both chorioallantoic membrane and mouse models

  A. Komatsu; Y. Higashi; C. K Lin; Y. P. Chen; S. H. Wu; M. Suzuki; K. Matsumoto; F. Tamanoi

  Cells, May 2025, Peer-reviewed, Corresponding author

  
• Development and characterization of magnetic-based biodegradable periodic mesoporous organosilica nanoparticles for enhanced biomedical applications

  H. K. T. Ta; D. N.; X. Nai; Hanh-Vy. T. Nguyen; K. Matsumoto; T. B. Phan; F. Tamanoi; T. L.; H. Doan

  Journal of Industrial and Engineering Chemistry, Feb. 2025, Peer-reviewed

  
• Auger electrons and DNA double-strand breaks studied by using iodine-containing chemicals

  Y. Higashi; Y. Ma; K. Matsumoto; A. Shiro; H. Saito; T. Kawachi; F. Tamanoi

  The Enzymes, Sep. 2022, Peer-reviewed

  
• Various CAM tumor models

  A. Komatsu; Y. Higashi; K. Matsumoto

  The Enzymes, Oct. 2019, Peer-reviewed, Last author

  
• Tumor targeting and tumor inhibition capability of biodegradable PMO as examined by using chicken egg tumor model

  K. Matsumoto, T. L.H. Doan, D. N.X. Mai, F. Tamanoi

  The Enzymes, 2018, Peer-reviewed, Lead author

  
• Use of mesoporous silica nanoparticles to deliver anticancer agents in animal models

  T. L.; H. Doan; D. N. X. Mai; K. Matsumoto; F. Tamanoi

  he Enzymes, 2018, Peer-reviewed

  
• Strategist PLGA nano-capsules to deliver siRNA for inhibition of carcinoma and neuroblastoma cell lines by knockdown of MYC proto-oncogene using CPPs and PNA

  A. Raichur; T. Nakajima; Y. Nagaoka; K. Matsumoto; T. Mizuki; K. Kato; T. Maekawa; D. S. Kumar

  NanoWorld Journal, Apr. 2015, Peer-reviewed

  
• Activation of the phospholipase C signaling pathway in nerve growth factor-treated neurons by carbon nanotubes

  K. Matsumoto; N. Shimizu

  Biomaterials, Aug. 2013, Peer-reviewed, Lead author

  
• Stimulation of neuronal neurite outgrowth using functionalized carbon nanotubes

  K. Matsumoto; C. Sato; Y. Naka; R. L.; D. Whitby; N. Shimizu

  Nanotechnology, Mar. 2010, Peer-reviewed, Lead author

  
• Neurite outgrowths of neurons with neurotrophin-coated carbon nanotubes

  K. Matsumoto; C. Sato; Y. Naka; A. Kitazawa; R. L.; D. Whitby; N. Shimizu

  Journal of Bioscience and Bioengineering, Mar. 2007, Peer-reviewed, Lead author

  
• Tumor Targeting and Tumor Growth Inhibition Capability of Mesoporous Silica Nanoparticles in Mouse Models

  Tan Le Hoang Doan; Ngoc Xuan Dat Mai; Kotaro Matsumoto; Fuyuhiko Tamanoi

  Enzymes, 01 Jan. 2018

  
• Anticancer Drug Delivery Capability of Biodegradable PMO in the Chicken Egg Tumor Model

  Kotaro Matsumoto; Tan Le Hoang Doan; Ngoc Xuan Dat Mai; Keigo Nakai; Aoi Komatsu; Fuyuhiko Tamanoi

  Enzymes, 01 Jan. 2018, Lead author

  
• Organosilica nanoparticles containing sodium borocaptate (BSH) provide new prospects for boron neutron capture therapy (BNCT): efficient cellular uptake and enhanced BNCT efficacy.

  Mathilde Laird; Kotaro Matsumoto; Yuya Higashi; Aoi Komatsu; Art Raitano; Kendall Morrison; Minoru Suzuki; Fuyuhiko Tamanoi

  Nanoscale advances, 02 May 2023

  Access this paper :

  
• Tumor Accumulation of PIP-Based KRAS Inhibitor KR12 Evaluated by the Use of a Simple, Versatile Chicken Egg Tumor Model

  Yuya Higashi; Shuji Ikeda; Kotaro Matsumoto; Shinsuke Satoh; Aoi Komatsu; Hiroshi Sugiyama; Fuyuhiko Tamanoi

  Cancers, 14 Feb. 2022, Peer-reviewed

  
• The CAM Model for CIC-DUX4 Sarcoma and Its Potential Use for Precision Medicine

  Aoi Komatsu; Kotaro Matsumoto; Yuki Yoshimatsu; Yooksil Sin; Arisa Kubota; Tomoki Saito; Ayaka Mizumoto; Shinya Ohashi; Manabu Muto; Rei Noguchi; Tadashi Kondo; Fuyuhiko Tamanoi

  Cells, 01 Oct. 2021, Peer-reviewed

  
• Iodine containing porous organosilica nanoparticles trigger tumor spheroids destruction upon monochromatic X-ray irradiation: DNA breaks and K-edge energy X-ray

  Yuya Higashi; Kotaro Matsumoto; Hiroyuki Saitoh; Ayumi Shiro; Yue Ma; Mathilde Laird; Shanmugavel Chinnathambi; Albane Birault; Tan Le Hoang Doan; Ryo Yasuda; Toshiki Tajima; Tetsuya Kawachi; Fuyuhiko Tamanoi

  Scientific Reports, Dec. 2021, Peer-reviewed

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• Construction of boronphenylalanine-loaded biodegradable periodic mesoporous organosilica nanoparticles for BNCT cancer therapy

  Fuyuhiko Tamanoi; Shanmugavel Chinnathambi; Mathilde Laird; Aoi Komatsu; Albane Birault; Takushi Takata; Tan Le Hoang Doan; Ngoc Xuan Dat Mai; Arthur Raitano; Kendall Morrison; Minoru Suzuki; Kotaro Matsumoto

  International Journal of Molecular Sciences, Feb. 2021, Peer-reviewed, Last author

  
• Designing mesoporous silica nanoparticles to overcome biological barriers by incorporating targeting and endosomal escape

  Miguel Gisbert-Gazaran; Daniel Lozano; Kotaro Matsumoto; Aoi Komatsu; Miguel Manzano; Fuyuhiko Tamanoi; Maria Vallet-Regi

  ACS Applied Materials & Interfaces, Feb. 2021, Peer-reviewed

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• Studies on the exposure of Gadolinium containing nanoparticles with Monochromatic X-rays drive advances in radiation therapy

  Fuyuhiko Tamanoi; Kotaro Matsumoto; Tan Le Hoang Doan; Ayumi Shiro; Hiroyuki Saito

  Nanomaterials, Jul. 2020, Peer-reviewed

  
• Biodegradable periodic mesoporous organosilica (BPMO) loaded with Daunorubicin: A promising nanoparticle-based anticancer drug

  Ngoc Xuan; Dat Mai; Albane Birault; Kotaro Matsumoto; Hanh Kieu Thi Ta; Soontaree Grace Intasa-ard; Kendall Morrison; Phan Bach Thang; Tan Le Hoang Doan; Fuyuhiko Tamanoi

  ChemMedChem, Feb. 2020, Peer-reviewed

  
• Destruction of tumor mass by gadolinium-loaded nanoparticles irradiated with monochromatic X-rays: Implications for the Auger therapy

  Kotaro Matsumoto; Hiroyuki Saito; Tan Le-Hoang Doan; Ayumi Shiro; Keigo Nakai; Aoi Komatsu; Masahiko; Tsujimoto; Ryo Yasuda; Tetsuya Kawachi; Toshiki Tajima; Fuyuhiko Tamanoi

  Scientific reports, Sep. 2019, Peer-reviewed, Lead author

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• Patient Derived Chicken Egg Tumor Model (PDcE Model): Current Status and Critical Issues.

  Aoi Komatsu; Kotaro Matsumoto; Tomoki Saito; Manabu Muto; Fuyuhiko Tamanoi

  Cells, 10 May 2019, Peer-reviewed

  
• Chick chorioallantoic membrane assay as an in vivo model to study the effect of nanoparticle-based anticancer drugs in ovarian cancer.

  Binh Thanh Vu; Sophia Allaf Shahin; Jonas Croissant; Yevhen Fatieiev; Kotaro Matsumoto; Tan Le-Hoang Doan; Tammy Yik; Shirleen Simargi; Altagracia Conteras; Laura Ratliff; Chiara Mauriello Jimenez; Laurence Raehm; Niveen Khashab; Jean-Olivier Durand; Carlotta Glackin; Fuyuhiko Tamanoi

  Scientific reports, 04 Jun. 2018, Peer-reviewed

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Misc.

• がんの個別化医療を切り拓く鶏卵モデル

  玉野井 冬彦; 遠藤 良夫; 宇都 義浩; 楠橋 由貴; 二若 真菜; 松本 光太郎

  実験医学, Jan. 2019

  

Presentations

• Establishment of chicken chorioallantoic membrane (CAM) model and application to BNCT experiment using BPA-loaded silica nanoparticles

  Kotaro Matsumoto; Mathilde Laird; Aoi Komatsu; Shanmugavel Chinnathambi; Takushi Takata; Minoru Suzuki; Fuyuhiko Tamanoi

  The 17th Congress on Neutron Capture Therapy, 10 Jul. 2021

  
• Evaluation of novel nanoparticle-based anticancer drugs for cancer therapy by using ovarian cancer-transplanted chicken chorioallantoic membrane (CAM).

  Kotaro Matsumoto

  Proceedings of the 6th Japan-Chaina symposium on nanomedicine, 25 May 2018

  

Books and Other Publications

• がんの個別化医療を切り拓く鶏卵モデル

  玉野井冬彦; 遠藤良夫; 宇都義浩; 楠橋由貴; 二若真菜; 松本光太郎, Joint work

  実験医学, Jan. 2019

  

Media Coverage

• Tiny silica particles show surprising promise in stopping tumor growth

  ScienceFeatured.com, ScienceFeatured, Oct. 2025, Internet

  

External funds: Kakenhi

• がんAuger治療で放射線治療の低酸素問題解決を目指す

  Grant-in-Aid for Scientific Research (C)

  Basic Section 52040:Radiological sciences-related

  Kyoto University

  松本 光太郎

  From 01 Apr. 2024, To 31 Mar. 2027, Granted

  オージェ電子;I-Hoechst;放射線増感効果;低酸素状態の腫瘍;Auger電子;単色X線;ヨウ素含有Hoechst;がんスフェロイド

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K10758/