Basic Information

Academic Degree

• 博士（医学）(京都大学)

Research History

• From Apr. 2024, To Present

  Clinical Fellow, Department of Psychiatry, Kyoto University Hospital
• From Apr. 2022, To Mar. 2024

  Researcher, Department of Psychiatry, Kyoto University Hospital
• From Apr. 2020, To Mar. 2022

  Resident doctor, Kyoto University Hospital
• From Apr. 2019, To Mar. 2020

  Graduate School of Informatics, Kyoto University
• From Apr. 2017, To Mar. 2019

  Graduate School of Informatics, Kyoto University
• From Apr. 2010, To Mar. 2015

  Graduate School of Medicine, Kyoto University

ID,URL

• J-Global ID

  201901005314928498

researchmap URL

• https://researchmap.jp/yoshihisa_fujita

Research

Research Topics, Overview of the research

• Research Topics

  生命現象の数理モデリング

• Overview of the research

  複雑な生命現象の背後にあるメカニズムを理論的手法を用いて理解することを目指す。数理モデル構築、シミュレーションおよび大規模実験データの解析を駆使して研究を行う。

Research Areas

• Life sciences, Cell biology, システム生物学
• Life sciences, Neuroscience - general, 計算論的神経科学

Papers

• Fine-tuning of dopamine receptor signaling with aripiprazole counteracts ketamine’s dissociative action, but not its antidepressant effect

  Daiki Nakatsuka; Taro Suwa; Yuichi Deguchi; Yoshihisa Fujita; Ryoichi Tashima; Soichiro Ohnami; Hirotsugu Kawashima; Naoya Oishi; Koichi Ogawa; Hidekuni Yamakawa; Toshiya Murai

  Translational Psychiatry, 08 Mar. 2025, Peer-reviewed

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• Electroconvulsive therapy-specific volume changes in nuclei of the amygdala and their relationship to long-term anxiety improvement in depression

  Yuzuki Ishikawa; Naoya Oishi; Yusuke Kyuragi; Momoko Hatakoshi; Jinichi Hirano; Takamasa Noda; Yujiro Yoshihara; Yuri Ito; Jun Miyata; Kiyotaka Nemoto; Yoshihisa Fujita; Hiroyuki Igarashi; Kento Takahashi; Shingo Murakami; Hiroyuki Kanno; Yudai Izumi; Akihiro Takamiya; Junya Matsumoto; Fumitoshi Kodaka; Kazuyuki Nakagome; Masaru Mimura; Toshiya Murai; Taro Suwa

  Molecular Psychiatry, 16 Dec. 2024, Peer-reviewed

  
• Computational Characteristics of the Striatal Dopamine System Described by Reinforcement Learning With Fast Generalization

  Yoshihisa Fujita; Sho Yagishita; Haruo Kasai; Shin Ishii

  Frontiers in Computational Neuroscience, Jul. 2020, Peer-reviewed

  
• Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine

  Yu Muta; Yoshihisa Fujita; Kenta Sumiyama; Atsuro Sakurai; M. Mark Taketo; Tsutomu Chiba; Hiroshi Seno; Kazuhiro Aoki; Michiyuki Matsuda; Masamichi Imajo

  Nature Communications, 01 Dec. 2018, Peer-reviewed

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• mTORC1 upregulation via ERK-dependent gene expression change confers intrinsic resistance to MEK inhibitors in oncogenic KRas-mutant cancer cells

  N. Komatsu; Y. Fujita; M. Matsuda; K. Aoki

  ONCOGENE, Nov. 2015, Peer-reviewed

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• Intercellular propagation of extracellular signal-regulated kinase activation revealed by in vivo imaging of mouse skin

  Toru Hiratsuka; Yoshihisa Fujita; Honda Naoki; Kazuhiro Aoki; Yuji Kamioka; Michiyuki Matsuda

  ELIFE, Feb. 2015, Peer-reviewed

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• Fluorescence resonance energy transfer based quantitative analysis of feedforward and feedback loops in epidermal growth factor receptor signaling and the sensitivity to molecular targeting drugs

  Yoshihisa Fujita; Naoki Komatsu; Michiyuki Matsuda; Kazuhiro Aoki

  FEBS JOURNAL, Jul. 2014, Peer-reviewed

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• Stochastic ERK activation induced by noise and cell-to-cell propagation regulates cell density-dependent proliferation

  Kazuhiro Aoki; Yuka Kumagai; Atsuro Sakurai; Naoki Komatsu; Yoshihisa Fujita; Clara Shionyu; Michiyuki Matsuda

  Molecular Cell, 21 Nov. 2013, Peer-reviewed

  
• Development of an optimized backbone of FRET biosensors for kinases and GTPases

  Naoki Komatsu; Kazuhiro Aoki; Masashi Yamada; Hiroko Yukinaga; Yoshihisa Fujita; Yuji Kamioka; Michiyuki Matsuda

  MOLECULAR BIOLOGY OF THE CELL, Dec. 2011, Peer-reviewed

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• Multiple Decisive Phosphorylation Sites for the Negative Feedback Regulation of SOS1 via ERK

  Yuji Kamioka; Shuhei Yasuda; Yoshihisa Fujita; Kazuhiro Aoki; Michiyuki Matsuda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Oct. 2010, Peer-reviewed

  
• The Scaffold Protein Shoc2/SUR-8 Accelerates the Interaction of Ras and Raf

  Rie Matsunaga-Udagawa; Yoshihisa Fujita; Sayaka Yoshiki; Kenta Terai; Yuji Kamioka; Etsuko Kiyokawa; Katsuyuki Yugi; Kazuhiro Aoki; Michiyuki Matsuda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 2010, Peer-reviewed