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Ninomiya, Komaki
Graduate School of Pharmaceutical Sciences, Division of Bioinformatics and Chemical Genomics Assistant Professor
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Last Updated :2026/10/19
Basic Information
Email Address
Email Address
ninomiya.komaki.6m
kyoto-u.ac.jp
Professional Memberships
Academic Degree
Academic Resume (Undergraduate School/Majors)
Research History
- From Apr. 2025, To Present京都大学 薬学研究科 組織形成動力学分野, 助教
- From Apr. 2023, To Mar. 2025東北大学 大学院生命科学研究科 組織形成分野, 助教
- From Apr. 2022, To Mar. 2023東北大学 大学院生命科学研究科 組織形成分野, 助教 (研究特任)
- From Apr. 2021, To Mar. 2022Tohoku University, Graduate School of Life Sciences, JSPS research fellow
- From Apr. 2020, To Mar. 2021東北大学 大学院生命科学研究科, 日本学術振興会特別研究員 (DC)
ID,URL
ORCID ID
J-Global ID
Researcher number
30922950
researchmap URL
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Last Updated :2026/10/19
Research
Research Topics, Overview of the research
Research Topics
Cell Biology, Molecular Biology, Developmental Biology
Research Interests
Research Areas
- Life sciences, Cell biology
- Life sciences, Molecular biology
- Life sciences, Developmental biology
- Life sciences, Morphology, anatomy
Papers
- Calcium influx promotes PLEKHG4B localization to cell-cell junctions and regulates the integrity of junctional actin filaments.Komaki Ninomiya; Kai Ohta; Ukyo Kawasaki; Shuhei Chiba; Takanari Inoue; Erina Kuranaga; Kazumasa Ohashi; Kensaku MizunoMolecular biology of the cell, 13 Dec. 2023, Peer-reviewed, Lead author
- PLEKHG4B enables actin cytoskeletal remodeling during epithelial cell–cell junction formationKomaki Ninomiya; Kai Ohta; Kazunari Yamashita; Kensaku Mizuno; Kazumasa OhashiJournal of Cell Science, 15 Jan. 2021, Peer-reviewed, Lead author
Misc.
- (再録) Ca2+シグナルによる細胞接着の動態制御メカニズム二宮小牧; 大橋一正; 水野健作月刊「細胞」, May 2025, Invited, Lead author
- Dynamic regulation of cell adhesion by Ca2+ signalingKomaki Ninomiya; Kazumasa Ohashi; Kensaku Mizuno月刊「細胞」, Mar. 2025, Invited, Lead author
- First person – Komaki NinomiyaJournal of Cell Science, 15 Jan. 2021, Invited
Presentations
- Molecular mechanisms underlying focal deformation of the epithelial monolayer during tubulogenesisMinami Aoyama; Koshi Tasaki; Komaki Ninomiya; Erina KuranagaJoint Meeting of JSCB 77th and JSDB 58th, Jul. 2025
- Spatiotemporally coordinated ECM remodeling regulates collective cell migration during epithelial morphogenesisAyae Oshima; Komaki Ninomiya; Erina KuranagaJoint Meeting of JSCB 77th and JSDB 58th, Jul. 2025, Invited
- Coordinated cell cycle regulation drives collective cell migration during Drosophila genitalia morphogenesisKomaki Ninomiya; Ryota Shirasawa; Takayuki Iwatsuki; Ayae Oshima; Erina KuranagaJoint Meeting of JSCB 77th and JSDB 58th, Jul. 2025, Invited
- 上皮細胞層の局所における形態創出原理の解析青山美波; 二宮小牧; 倉永英里奈第47回日本分子生物学会年会, Nov. 2024
- Coordination between cell cycle regulation and collective cell migration during morphogenesisKomaki Ninomiya; Ayae Oshima; Ryota Shirasawa; Takayuki Iwatsuki; Erina Kuranaga16th Japan Drosophila Research Conference, Sep. 2024
- 上皮形態形成時の集団細胞移動を制御するECMシグナル動態の解析大島 綾笑; 二宮 小牧; 倉永 英里奈第76回日本細胞生物学会大会, Jul. 2024
- Relationship between cell cycle and collective cell movement during Drosophila epithelial morphogenesisKomaki Ninomiya; Ryota shirasawa; Takayuki Iwatsuki; Ayae Oshima; Erina Kuranaga第76回日本細胞生物学会大会, Jul. 2024, Invited
- Collective epithelial cell movement is associated with G1 arrest synchronizationKomaki Ninomiya; Ryota Shirasawa; Takayuki Iwatsuki; Ayae Oshima; Erina Kuranaga日本分子生物学会年会, Dec. 2023
- 上皮形態形成時の集団細胞移動における細胞外基質ダイナミクスとそのシグナル経路の解析大島綾笑; 二宮小牧; 倉永英里奈第34回高遠シンポジウム, Aug. 2023
- 上皮形態形成において細胞集団移動を支える細胞周期のシンクロ機構二宮小牧、白澤諒太、岩月貴之、大島綾笑、倉永英里奈第34回高遠シンポジウム, Aug. 2023
- Contribution of ECM dynamics and its signaling pathways in collective cell migration during epithelial morphogenesisAyae Oshima; Komaki Ninomiya; Erina KuranagaThe 56th Annual Meeting of the Japanese Society of Developmental Biologists, Jul. 2023
- The role of G1 cell cycle phase in collective cell migration during Drosophila epithelial morphogenesisKomaki Ninomiya; Ryota Shirasawa; Takayuki Iwatsuki; Ayae Oshima; Erina KuranagaThe 56th Annual Meeting of the Japanese Society of Developmental Biologists, Jul. 2023
- 上皮組織の集団細胞移動における細胞周期依存的な制御メカニズムの解明二宮 小牧; 白澤 諒太; 岩月 貴之; 大島 綾笑; 倉永 英里奈第75回細胞生物学会大会, Jun. 2023
- 上皮細胞集団が局所的な管腔構造を決定する制御メカニズムの解析青山 美波; 二宮 小牧; 倉永 英里奈第75回細胞生物学会大会, Jun. 2023
- 間葉系幹細胞の脂肪細胞分化に関与するRhoGEFの網羅的探索田村 祥太郎; 鈴木 充喜; 二宮 小牧; 水野 健作; 大橋 一正日本分子生物学会年会, Dec. 2022
- Ca2+ influx promotes junctional localization of Cdc42-targetin GEF, PLEKHG4B, to organize junctional actin structure in epithelial cellsKomaki Ninomiya, Kai Ohta, Kazumasa Ohashi, Kensaku Mizuno日本分子生物学会年会, Dec. 2022
- Synchronous G1 phase arrest governs collective migration activity of epithelial cellsKomaki Ninomiya; Ryota Shirasawa; Takayuki Iwatsuki; Erina Kuranaga15th Japan Drosophila Research Conference, Sep. 2022
- PLEKHG4Bによる細胞間接着形成過程のアクチン骨格再構築メカニズム二宮小牧; 太田海; 水野健作; 大橋一正第73回日本細胞生物学会大会, Jun. 2021
- 上皮細胞のアクチン骨格制御と細胞間接着形成におけるRho-GEF, PLEKHG4Bの機能二宮小牧; 太田海; 山下和成; 水野健作; 大橋一正第43回日本分子生物学会年会 MBSJ2020 online, Dec. 2020
- PLEKHG4BはRac1とCdc42を介して細胞間接着の形成を促進する二宮小牧、太田海、山下和成、水野健作、大橋一正第72回日本細胞生物学会大会, Jun. 2020
- 上皮細胞のアクチン骨格制御と細胞間接着形成におけるRho-GEF, PLEKHG4Bの機能二宮小牧; 水野健作; 大橋一正第42回日本分子生物学会年会, Dec. 2019
- Functions of Rho-GEF, PLEKHG4B in cell-cell junction formationNinomiya, K; Mizuno, K; Ohashi, KUCL-TU kick-off partnership event, Oct. 2018
- 細胞間接着形成に関与するRho-GEF, PLEKHG4Bの機能解析二宮小牧; 水野健作; 大橋一正第91回日本生化学会大会, Sep. 2018
- Functional roles of Rho-GEF PLEKHG4B in the formation of adherens junctionsNinomiya, K; Mizuno, K; Ohashi, KJoint Annual Meeting of 51st JSDB and 70th JSCB, Jun. 2018
- Functions of Rho-GEF, PLEKHG4B in actin cytoskeletal remodeling and cell-cell junction formationNinomiya, K; Mizuno, K; Ohashi, KKick-off Symposium of International Graduate Program for Data Science, Feb. 2018
- Rho-GEF, PLEKHG4Bによるアクチン骨格再構築と細胞間接着形成における機能二宮小牧; 水野健作; 大橋一正第40回日本分子生物学会年会, Dec. 2017
- Functional analysis of Rho-GEF, PLEKHG4B in actin cytoskeletal reorganization and cell-cell adhesionsNinomiya, K; Mizuno, K; Ohashi, KThird International Symposium on Cell Competition, Aug. 2017
- Functional roles of PLEKHG4B in actin cytoskeletal reorganization and cell-cell adhesions.Ninomiya, K; Mizuno, K; Ohashi, KThird Annual Data and Life Science Collaboration and Symposium, Aug. 2017
- PLEKHG4Bのアクチン骨格再構築、細胞間接着における機能二宮小牧; 大橋一正; 水野健作第69回日本細胞生物学会大会, Jun. 2017
- アクチン骨格再構築及び細胞間接着形成におけるRho-GEF, PLEKHG4Bの機能解明二宮小牧; 水野健作; 大橋一正第83回日本生化学会東北支部会例会, May 2017
Awards
Media Coverage
- 細胞内アクチン骨格の制御因子PLEKHG4BのCa2+依存的な細胞内局在と細胞間接着形成の制御機構東北大学大学院理学研究科・理学部, 最新の研究成果 (東北大学 理学部化学科・大学院理学研究科化学専攻HP), Dec. 2023
External funds: Kakenhi
- Multicellular coordination through Ca2+-mediated cytoskeletal dynamicsGrant-in-Aid for Early-Career ScientistsBasic Section 44010:Cell biology-relatedTohoku UniversityKomaki NinomiyaFrom 01 Apr. 2022, To 31 Mar. 2025, Project Closed上皮細胞;細胞骨格;細胞接着;Ca2+;ショウジョウバエ;形態形成;Rho-GEF;機械刺激受容チャネル;細胞集団移動;組織形成;カルシウムイオン;Rho GEF;アクチン細胞骨格
External funds: others
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Last Updated :2026/10/19
Education
Teaching subject(s)
- From 01 Apr. 2026, To 31 Mar. 2027Pharmaceutical Laboratory Coaching Practice B8302, Year-long, Graduate School of Pharmaceutical Sciences, 1
- From 01 Apr. 2026, To 31 Mar. 2027Pharmaceutical Laboratory Coaching Practice A8301, Year-long, Graduate School of Pharmaceutical Sciences, 1
- From 01 Apr. 2026, To 31 Mar. 2027Research Proposal Writing Practice B8403, Year-long, Graduate School of Pharmaceutical Sciences, 1
- From 01 Apr. 2026, To 31 Mar. 2027Research Proposal Writing Practice A8402, Year-long, Graduate School of Pharmaceutical Sciences, 1
- From 01 Apr. 2026, To 31 Mar. 2027Seminar on Critical Reading of Scientific Papers B8405, Year-long, Graduate School of Pharmaceutical Sciences, 2
- From 01 Apr. 2026, To 31 Mar. 2027Seminar on Critical Reading of Scientific Papers A8404, Year-long, Graduate School of Pharmaceutical Sciences, 2
- From 01 Apr. 2026, To 31 Mar. 2027Medicinal Frontier Science Research C8408, Year-long, Graduate School of Pharmaceutical Sciences, 4
- From 01 Apr. 2026, To 31 Mar. 2027Medicinal Frontier Science Research B8407, Year-long, Graduate School of Pharmaceutical Sciences, 4
- From 01 Apr. 2026, To 31 Mar. 2027Medicinal Frontier Science Research A8406, Year-long, Graduate School of Pharmaceutical Sciences, 4
- From 01 Apr. 2025, To 31 Mar. 2026Research Proposal Writing Practice B8403, Year-long, Graduate School of Pharmaceutical Sciences, 1
- From 01 Apr. 2025, To 31 Mar. 2026Research Proposal Writing Practice A8402, Year-long, Graduate School of Pharmaceutical Sciences, 1
- From 01 Apr. 2025, To 31 Mar. 2026Pharmaceutical Laboratory Coaching Practice B8302, Year-long, Graduate School of Pharmaceutical Sciences, 1
- From 01 Apr. 2025, To 31 Mar. 2026Pharmaceutical Laboratory Coaching Practice A8301, Year-long, Graduate School of Pharmaceutical Sciences, 1
- From 01 Apr. 2025, To 31 Mar. 2026Seminar on Critical Reading of Scientific Papers B8405, Year-long, Graduate School of Pharmaceutical Sciences, 2
- From 01 Apr. 2025, To 31 Mar. 2026Seminar on Critical Reading of Scientific Papers A8404, Year-long, Graduate School of Pharmaceutical Sciences, 2
- From 01 Apr. 2025, To 31 Mar. 2026Medicinal Frontier Science Research C8408, Year-long, Graduate School of Pharmaceutical Sciences, 4
- From 01 Apr. 2025, To 31 Mar. 2026Medicinal Frontier Science Research B8407, Year-long, Graduate School of Pharmaceutical Sciences, 4
- From 01 Apr. 2025, To 31 Mar. 2026Medicinal Frontier Science Research A8406, Year-long, Graduate School of Pharmaceutical Sciences, 4
