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Nishinaka-Arai Yoko
Graduate School of Medicine, Department of Human Health Sciences Assistant Professor
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Last Updated :2025/05/02
Basic Information
Faculty
Email Address
Email Address
nishinaka.yoko.6x
kyoto-u.ac.jp
Professional Memberships
- From Jan. 2024, To PresentAmerican Society of Hematology
- From 2017, To Present日本酸化ストレス学会
- From 2013, To Present日本血液学会
Academic Degree
Academic Resume (Graduate Schools)
Academic Resume (Undergraduate School/Majors)
High School
High School
大阪教育大学附属高等学校天王寺校舎
Research History
- From Aug. 2019, To Present京都大学大学院 医学研究科人間健康科学系専攻, 助教
- From Nov. 2017, To Jul. 2019京都大学iPS細胞研究所, 特定研究員
- From Jul. 2017, To Dec. 2017National Institutes of Health, Guest Researcher
- From Apr. 2015, To Oct. 2017Japan Society for the Promotion of Science, 特別研究員(PD)
- From Apr. 2013, To Mar. 2015京都大学iPS細胞研究所, 特定研究員
- From Apr. 2011, To Mar. 2013Japan Society for the Promotion of Science, 特別研究員(DC2)
Language of Instruction
ID,URL
J-Global ID
researchmap URL
list
Last Updated :2025/05/02
Research
Research Interests
Research Areas
- Life sciences, Pathobiochemistry, 活性酸素種
- Life sciences, Cell biology
- Life sciences, Fetal medicine/Pediatrics
- Life sciences, Hematology and oncology
- Life sciences, Infectious disease
Papers
- Dysregulation of DNA Methylation Involves in Progression of Myeloid Leukemia in Down SyndromeSaida Satoshi; Nakamura Masahiro; Toki Tsutomu; Nishinaka-Arai Yoko; Terui Kiminori; Yoshida Kenichi; Ogawa Seishi; Nakahata Tatsutoshi; Heike Toshio; Watanabe Ken-ichiro; Watanabe Akira; Ito EtsuroBLOOD, 03 Dec. 2015, Peer-reviewed
- VEGFA- a New Therapeutic Target in CNS LeukemiaKato Itaru; Nishinaka-Arai Yoko; Nakamura Masahiro; Akarca Ayse U; Niwa Akira; Ozawa Hiroki; Yoshida Kenichi; Mori Makiko; Wang Dapeng; Ueno Hiroo; Shiozawa Yusuke; Shiraishi Yuichi; Miyano Satoru; Gupta Rajeev; Umeda Katsutsugu; Watanabe Kenichiro; Koh Katsuyoshi; Adachi Souichi; Heike Toshio; Saito Megumu K; Sanada Masashi; Ogawa Seishi; Marafioti Teresa; Watanabe Akira; Nakahata Tatsutoshi; Enver TariqBLOOD, 02 Dec. 2016, Peer-reviewed
- Identification of Candidate Progenitor Populations Which Causes Transient Abnormal MyelopoiesisNishinaka-Arai Yoko; Niwa Akira; Matsuo Shiori; Kazuki Yasuhiro; Yakura Yuwna; Oshimura Mitsuo; Nakahata Tatsutoshi; Saito Megumu KBLOOD, 07 Dec. 2017, Peer-reviewed
- Exploring the Pathogenesis of Down Syndrome-Related Myeloproliferative Disorders Using iPSCsNishinaka Yoko; Akira Niwa; Mitsujiro Osawa; Akira Watanabe; Tatsutoshi Nakahata; Megumu K. SaitoBLOOD, Dec. 2014, Peer-reviewed
- Albendazole induces the terminal differentiation of acute myeloid leukaemia cells to monocytes by stimulating the Krüppel-like factor 4-dihydropyrimidinase-like 2A (KLF4-DPYSL2A) axis.Mina Noura; Ken Morita; Hiroki Kiyose; Yukiko Okuno; Hidemasa Matsuo; Asami Koyama; Yoko Nishinaka-Arai; Yasuhiko Kamikubo; Souichi AdachiBritish journal of haematology, Aug. 2021
- Pluripotent stem cell model of early hematopoiesis in Down syndrome reveals quantitative effects of short-form GATA1 protein on lineage specification.Shiori Matsuo; Yoko Nishinaka-Arai; Yasuhiro Kazuki; Mitsuo Oshimura; Tatsutoshi Nakahata; Akira Niwa; Megumu K SaitoPloS one, Mar. 2021, Peer-reviewed, Corresponding author
- Inhibition of CDK4/6 and autophagy synergistically induces apoptosis in t(8;21) acute myeloid leukemia cells.Kana Nakatani; Hidemasa Matsuo; Yutarou Harata; Moe Higashitani; Asami Koyama; Mina Noura; Yoko Nishinaka-Arai; Yasuhiko Kamikubo; Souichi AdachiInternational journal of hematology, Feb. 2021, Peer-reviewed
- Down syndrome-related transient abnormal myelopoiesis is attributed to a specific erythro-megakaryocytic subpopulation with GATA1 mutation.Yoko Nishinaka-Arai; Akira Niwa; Shiori Matsuo; Yasuhiro Kazuki; Yuwna Yakura; Takehiko Hiroma; Tsutomu Toki; Tetsushi Sakuma; Takashi Yamamoto; Etsuro Ito; Mitsuo Oshimura; Tatsutoshi Nakahata; Megumu K SaitoHaematologica, 01 Feb. 2021, Peer-reviewed, Lead author
- Pivotal role of DPYSL2A in KLF4-mediated monocytic differentiation of acute myeloid leukemia cells.Mina Noura; Ken Morita; Hiroki Kiyose; Hidemasa Matsuo; Yoko Nishinaka-Arai; Mineo Kurokawa; Yasuhiko Kamikubo; Souichi AdachiScientific reports, 20 Nov. 2020, Peer-reviewed
- Genome-wide microhomologies enable precise template-free editing of biologically relevant deletion mutations.Janin Grajcarek; Jean Monlong; Yoko Nishinaka-Arai; Michiko Nakamura; Miki Nagai; Shiori Matsuo; David Lougheed; Hidetoshi Sakurai; Megumu K Saito; Guillaume Bourque; Knut WoltjenNature communications, 24 Oct. 2019, Peer-reviewed
- Postnatal development of lymphatic vasculature in the brain meninges.Rebecca M Izen; Tomoko Yamazaki; Yoko Nishinaka-Arai; Young-Kwon Hong; Yoh-Suke MukouyamaDevelopmental dynamics : an official publication of the American Association of Anatomists, May 2018, Peer-reviewed
- Hypoxic adaptation of leukemic cells infiltrating the CNS affords a therapeutic strategy targeting VEGFA.Itaru Kato; Yoko Nishinaka; Masahiro Nakamura; Ayse U Akarca; Akira Niwa; Hiroki Ozawa; Kenichi Yoshida; Makiko Mori; Dapeng Wang; Makiko Morita; Hiroo Ueno; Yusuke Shiozawa; Yuichi Shiraishi; Satoru Miyano; Rajeev Gupta; Katsutsugu Umeda; Kenichiro Watanabe; Katsuyoshi Koh; Souichi Adachi; Toshio Heike; Megumu K Saito; Masashi Sanada; Seishi Ogawa; Teresa Marafioti; Akira Watanabe; Tatsutoshi Nakahata; Tariq EnverBlood, 08 Jun. 2017, Peer-reviewed
- Dasatinib induces autophagy in mice with Bcr-Abl-positive leukemia.Makiko Morita; Yoko Nishinaka; Itaru Kato; Satoshi Saida; Hidefumi Hiramatsu; Yasuhiko Kamikubo; Toshio Heike; Tatsutoshi Nakahata; Souichi AdachiInternational journal of hematology, Mar. 2017, Peer-reviewed
- Laminin-guided highly efficient endothelial commitment from human pluripotent stem cells.Ryo Ohta; Akira Niwa; Yukimasa Taniguchi; Naoya M Suzuki; Junko Toga; Emiko Yagi; Norikazu Saiki; Yoko Nishinaka-Arai; Chihiro Okada; Akira Watanabe; Tatsutoshi Nakahata; Kiyotoshi Sekiguchi; Megumu K SaitoScientific reports, 02 Nov. 2016, Peer-reviewed
- CXCR4 Overexpression is a Poor Prognostic Factor in Pediatric Acute Myeloid Leukemia With Low Risk: A Report From the Japanese Pediatric Leukemia/Lymphoma Study Group.Hidemasa Matsuo; Naomi Nakamura; Daisuke Tomizawa; Akiko Moriya Saito; Nobutaka Kiyokawa; Keizo Horibe; Yoko Nishinaka-Arai; Mayu Tokumasu; Hiroshi Itoh; Yasuhiko Kamikubo; Hideki Nakayama; Akitoshi Kinoshita; Takashi Taga; Akio Tawa; Tomohiko Taki; Shiro Tanaka; Souichi AdachiPediatric blood & cancer, Aug. 2016, Peer-reviewed
- In vitro expansion of CD34(+)CD38(-) cells under stimulation with hematopoietic growth factors on AGM-S3 cells in juvenile myelomonocytic leukemiaK. Sakashita; I. Kato; T. Daifu; S. Saida; H. Hiramatsu; Y. Nishinaka; Y. Ebihara; F. Ma; K. Matsuda; S. Saito; K. Hirabayashi; T. Kurata; L. T. N. Uyeni; Y. Nakazawa; K. Tsuji; T. Heike; T. Nakahata; K. KoikeLEUKEMIA, Mar. 2015, Peer-reviewed
- Uric acid induces NADPH oxidase-independent neutrophil extracellular trap formation.Yasuyuki Arai; Yoko Nishinaka; Toshiyuki Arai; Makiko Morita; Kiyomi Mizugishi; Souichi Adachi; Akifumi Takaori-Kondo; Tomohiro Watanabe; Kouhei YamashitaBiochemical and biophysical research communications, 10 Jan. 2014, Peer-reviewed, Lead author
- Singlet oxygen is essential for neutrophil extracellular trap formation.Yoko Nishinaka; Toshiyuki Arai; Souichi Adachi; Akifumi Takaori-Kondo; Kouhei YamashitaBiochemical and biophysical research communications, 16 Sep. 2011, Peer-reviewed, Lead author
- Identification of hepatic niche harboring human acute lymphoblastic leukemic cells via the SDF-1/CXCR4 axis.Itaru Kato; Akira Niwa; Toshio Heike; Hisanori Fujino; Megumu K Saito; Katsutsugu Umeda; Hidefumi Hiramatsu; Mamoru Ito; Makiko Morita; Yoko Nishinaka; Souichi Adachi; Fumihiko Ishikawa; Tatsutoshi NakahataPloS one, 2011, Peer-reviewed
- Edaravone directly reacts with singlet oxygen and protects cells from attack.Yoko Nishinaka; Hiroko Mori; Nobuyuki Endo; Takashi Miyoshi; Kouhei Yamashita; Souichi Adachi; Toshiyuki AraiLife sciences, 22 May 2010, Peer-reviewed, Lead author
- Substituent effects of pterin derivatives on singlet oxygen scavenging activity.Hiroko Mori; Yoko Nishinaka; Mitsuru Nonogawa; Piyanart Sommani; Keisuke Makino; Kouhei Yamashita; Toshiyuki AraiBiological & pharmaceutical bulletin, 2010, Peer-reviewed
- Alpha-phenyl-N-tert-butyl nitrone has scavenging activity against singlet oxygen ((1)O(2)) and attenuates (1)O(2)-induced neuronal cell death.Anna Kawai; Yoko Nishinaka; Toshiyuki Arai; Kiichi Hirota; Hiroko Mori; Nobuyuki Endo; Takashi Miyoshi; Kouhei Yamashita; Masataka SasadaJournal of pharmacological sciences, Dec. 2008, Peer-reviewed
- Effects of injectable propofol emulsion on singlet oxygen released from activated human neutrophils and that chemically generated.Chika Senda; Yoko Nishinaka; Toshiyuki Arai; Hajime Segawa; Hiroko Mori; Mitsuru Nonogawa; Nobuyuki Endo; Takashi Miyoshi; Kouhei Yamashita; Masataka SasadaJournal of pharmacological sciences, Aug. 2008, Peer-reviewed
- Effects of injectable propofol emulsion on singlet oxygen released from activated human neutrophils and that chemically generatedChika Senda; Yoko Nishinaka; Toshiyuki Arai; Hajime Segawa; Hiroko Mori; Mitsuru Nonogawa; Nobuyuki Endo; Takashi Miyoshi; Kouhei Yamashita; Masataka SasadaJOURNAL OF PHARMACOLOGICAL SCIENCES, Aug. 2008, Peer-reviewed
- N-Acetylcysteine prevents amyloid-β secretion in neurons derived from human pluripotent stem cells with trisomy 21.Hiromitsu Toshikawa; Akihiro Ikenaka; Li Li; Yoko Nishinaka-Arai; Akira Niwa; Akira Ashida; Yasuhiro Kazuki; Tatsutoshi Nakahata; Hiroshi Tamai; David W Russell; Megumu K SaitoScientific reports, 30 Aug. 2021
Misc.
- 神経細胞内で発生させた一重項酸素により誘導される細胞死の検討西中瑶子; 山本美月; 足立壯一; 荒井俊之日本酸化ストレス学会学術集会プログラム・抄録集, 2014
- 神経細胞内で発生させた一重項酸素によるオートファジーの誘導西中瑶子; 荒井俊之; 足立壯一日本Cell Death学会学術集会プログラム抄録集, 2013
- 高濃度尿酸によるNADPH oxidase非依存性NETosisの誘導西中瑶子; 森田真紀子; 荒井俊之; 山下浩平; 足立壯一日本Cell Death学会学術集会プログラム抄録集, 2012
- 新規一重項酸素消去剤による細胞傷害の緩和西中瑶子; 遠藤伸之; 荒井俊之日本化学会講演予稿集, 2011
- NETosisにおける一重項酸素の役割西中瑶子; 森田真紀子; 山下浩平; 荒井俊之; 足立壯一日本Cell Death学会学術集会プログラム抄録集, 2011
- 細胞内で発生させた一重項酸素による細胞死に対するエダラボンの効果西中瑶子; 荒井俊之; 山下浩平; 足立壯一日本Cell Death学会学術集会プログラム抄録集, 2010
- N-アセチルシステインの一重項酸素消去能と細胞死について西中瑶子; 荒井俊之; 三好隆史; 山下浩平; 足立壯一日本アポトーシス研究会学術集会プログラム要旨集, 2009
- Autophagy Inhibition Enhances CDK4/6 Inhibitor-Induced Apoptosis in t(8;21) Acute Myeloid Leukemia CellsKana Nakatani; Hidemasa Matsuo; Yutarou Harata; Moe Higashitani; Asami Koyama; Mina Noura; Yoko Nishinaka-Arai; Yasuhiko Kamikubo; Souichi AdachiBLOOD, Nov. 2020
- Prognostic Significance of CXCR4 Overexpression in Pediatric Acute Myeloid Leukemia with Low-Risk: A Report from the Japanese Pediatric Leukemia/Lymphoma Study GroupHidemasa Matsuo; Naomi Nakamura; Daisuke Tomizawa; Akiko M. Saito; Nobutaka Kiyokawa; Keizo Horibe; Yoko Nishinaka-Arai; Mayu Tokumasu; Hiroshi Itoh; Yasuhiko Kamikubo; Hideki Nakayama; Akitoshi Kinoshita; Takashi Taga; Akio Tawa; Tomohiko Taki; Shiro Tanaka; Souichi AdachiBLOOD, Dec. 2015
- Prognostic significance of CXCR4 overexpression in pediatric AML: the JPLSG AML-05 studyMATSUO Hidemasa; MATSUO Hidemasa; NAKAMURA Naomi; TOMIZAWA Daisuke; WATANABE Tomoyuki; MORIYA SAITO Akiko; FUJIMOTO Jun‐ichiro; HORIBE Keizo; NISHINAKA Yoko; TOKUMASU Mayu; ITOH Hiroshi; KAMIKUBO Yasuhiko; NAKAYAMA Hideki; KINOSHITA Akitoshi; TAGA Takashi; TAWA Akio; TAKI Tomohiko; ADACHI Souichi臨床血液, 30 Sep. 2015
- ヒト多能牲幹細胞を用いた,完全無血清条件下での成体型ヘモグロビン産生赤芽球への効率的分化誘導法の開発丹羽明; 伊藤潤; 西中瑶子; 鈴木直也; 斎藤潤; 中畑龍俊再生医療, 01 Feb. 2015
- Uric Acid Induces NADPH Oxidase-Independent Neutrophil Extracellular Trap FormationYasuyuki Arai; Yoko Nishinaka; Toshiyuki Arai; Kiyomi Mizugishi; Souichi Adachi; Akifumi Takaori-Kondo; Kouhei YamashitaBLOOD, Nov. 2013
- A novel role of uric acid in neutrophil extracellular trap formationNISHINAKA Yoko; ARAI Toshiyuki; MORITA Makiko; ARAI Yasuyuki; MIZUGISHI Kiyomi; ADACHI Souichi; TAKAORI‐KONDO Akifumi; YAMASHITA Kouhei臨床血液, 30 Sep. 2012
- Singlet Oxygen Is Essential for Neutrophil Extracellular Trap FormationYoko Nishinaka; Makiko Morita; Toshiyuki Arai; Souichi Adachi; Akifumi Takaori-Kondo; Kouhei YamashitaBLOOD, Nov. 2011
- Singlet oxygen is essential for neutrophil extracellular trap formationYAMASHITA Kouhei; NISHINAKA Yoko; ARAI Toshiyuki; ADACHI Souichi; TAKAORI‐KONDO Akifumi臨床血液, 30 Sep. 2011
- Autophagy of Bcr-Abl+ Ieukemias in vivo induced by TKIsMORITA Makiko; NISHINAKA Yoko; BANDO Mika; SAIDA Satoshi; KATO Itaru; ITOH Hiroshi; HEIKE Toshio; NAKAHATA Tatsutoshi; ADACHI Souichi臨床血液, 30 Sep. 2011
Industrial Property Rights
- 特許第7297321号, JP2019049670, 抗酸化剤およびその用途牧野 圭祐; 荒井 俊之; 新井 瑶子; 李 昌一
- WO2020-158225, JP2019049670, 抗酸化剤およびその用途牧野 圭祐; 荒井 俊之; 新井 瑶子; 李 昌一
External funds: Kakenhi
- Exploring the mechanism of mutation acquisition to induce tumorigenesis using Down syndrome associated leukemia modelGrant-in-Aid for Early-Career ScientistsBasic Section 52050:Embryonic medicine and pediatrics-relatedKyoto UniversityYoko Nishinaka-AraiFrom 01 Apr. 2019, To 31 Mar. 2022, Project Closed一過性骨髄異常増殖症;発がん;多段階発がん;ダウン症候群;白血病
- 一過性骨髄異常増殖症の発症過程における短型GATA1タンパクの機能解析Grant-in-Aid for Early-Career ScientistsBasic Section 52050:Embryonic medicine and pediatrics-relatedKyoto University西中 瑶子From 01 Apr. 2022, To 31 Mar. 2024, Granted発がん;ダウン症候群;白血病;転写因子;一過性骨髄異常増殖症;GATA1sタンパク
- 一過性骨髄異常増殖症モデルを用いたがんのクローン進化のメカニズム解明Grant-in-Aid for Scientific Research (C)Basic Section 52050:Embryonic medicine and pediatrics-relatedKyoto University西中 瑶子From 01 Apr. 2024, To 31 Mar. 2027, Granted多段階発がん;ダウン症候群;白血病
list
Last Updated :2025/05/02
Education
Teaching subject(s)
- From 01 Apr. 2024, To 31 Mar. 2025Practice of Clinical Physiology and Diagnosis by Ultrasonogr8034, Fall, Faculty of Medicine, 1
- From 01 Apr. 2024, To 31 Mar. 2025Practice of Hematology8013, Spring, Faculty of Medicine, 1
- From 01 Apr. 2024, To 31 Mar. 2025Physiology Practice3241, Fall, Faculty of Medicine, 1
- From 01 Apr. 2024, To 31 Mar. 2025Clinical research and development studies seminarM439, Fall, Graduate School of Medicine, 2
- From 01 Apr. 2024, To 31 Mar. 2025Laboratory medicine practice8051, Fall, Faculty of Medicine, 2
- From 01 Apr. 2024, To 31 Mar. 2025Practice of General Clinical Laboratory8038, Spring, Faculty of Medicine, 2
- From 01 Apr. 2024, To 31 Mar. 2025Learning Clinical Laboratory Medicine in Hospital8043, Fall, Faculty of Medicine, 8
- From 01 Apr. 2023, To 31 Mar. 2024Practice of Clinical Physiology and Diagnosis by Ultrasonogr8034, Fall, Faculty of Medicine, 1
- From 01 Apr. 2023, To 31 Mar. 2024Practice of Hematology8013, Spring, Faculty of Medicine, 1
- From 01 Apr. 2023, To 31 Mar. 2024Physiology Practice3241, Fall, Faculty of Medicine, 1
- From 01 Apr. 2023, To 31 Mar. 2024Clinical research and development studies seminarM439, Fall, Graduate School of Medicine, 2
- From 01 Apr. 2023, To 31 Mar. 2024Practice of General Clinical Laboratory8038, Spring, Faculty of Medicine, 2
- From 01 Apr. 2023, To 31 Mar. 2024Learning Clinical Laboratory Medicine in Hospital8043, Fall, Faculty of Medicine, 8
- From 01 Apr. 2022, To 31 Mar. 2023Clinical research and development studies advanced seminarD438, Year-long, Graduate School of Medicine, 4
- From 01 Apr. 2022, To 31 Mar. 2023Clinical research and development studies seminarM439, Fall, Graduate School of Medicine, 2
- From 01 Apr. 2022, To 31 Mar. 2023Clinical research and development studies advanced lectureD437, Year-long, Graduate School of Medicine, 4
- From 01 Apr. 2022, To 31 Mar. 2023Learning Clinical Laboratory Medicine in Hospital8043, Fall, Faculty of Medicine, 8
- From 01 Apr. 2022, To 31 Mar. 2023Physiology Practice3241, Fall, Faculty of Medicine, 1
- From 01 Apr. 2022, To 31 Mar. 2023Practice of Clinical Physiology and Diagnosis by Ultrasonogr8034, Fall, Faculty of Medicine, 1
- From 01 Apr. 2022, To 31 Mar. 2023Practice of Hematology8013, Spring, Faculty of Medicine, 1
- From 01 Apr. 2022, To 31 Mar. 2023Clinical research and development studies advanced researchD439, Year-long, Graduate School of Medicine, 4
- From 01 Apr. 2022, To 31 Mar. 2023Practice of General Clinical Laboratory8038, Spring, Faculty of Medicine, 2
- From Apr. 2020, To Mar. 2021Learning Clinical Laboratory Medicine in HospitalFall, 医学部（人間健康科学科）
- From Apr. 2020, To Mar. 2021Practice of Clinical Physiology and Diagnosis by UltrasonogrFall, 医学部（人間健康科学科）
- From Apr. 2021, To Mar. 2022Learning Clinical Laboratory Medicine in HospitalFall, 医学部（人間健康科学科）
- From Apr. 2021, To Mar. 2022Practice of General Clinical LaboratorySpring, 医学部（人間健康科学科）
- From Apr. 2021, To Mar. 2022Practice of Clinical Physiology and Diagnosis by UltrasonogrFall, 医学部（人間健康科学科）
- From Apr. 2021, To Mar. 2022Practice of HematologySpring, 医学部（人間健康科学科）
- From Apr. 2021, To Mar. 2022Clinical research and development studies advanced researchYear-long, 医学研究科（人間健康科学系専攻）
- From Apr. 2021, To Mar. 2022Clinical research and development studies advanced lectureYear-long, 医学研究科（人間健康科学系専攻）
- From Apr. 2021, To Mar. 2022Clinical research and development studies advanced seminarYear-long, 医学研究科（人間健康科学系専攻）
- From Apr. 2021, To Mar. 2022Clinical research and development studies seminarFall, 医学研究科（人間健康科学系専攻）
