Basic Information

Faculty

• Faculty of Medicine

Email Address

• Email Address

  sugiyama.nami.8mkyoto-u.ac.jp

Professional Memberships

• From Aug. 2021, To Present

  The Epithelial Mesenchymal Transition International Association
• From Apr. 2022, To Present

  The European Association for Cancer Research
• From Sep. 2021, To Present

  Metastatic Research Society
• From Sep. 2020, To Present

  The Molecular Biology Society of Japan
• From Nov. 2016, To Oct. 2023

  Basel Breast Consortium

Academic Degree

• 31 Mar. 2003

  東京水産大学修士（水産学）
• 24 Sep. 2013

  ヘルシンキ大学博士（医科学）

Academic Resume (Graduate Schools)

• ヘルシンキ大学, Doctor of Philosophy，Department of Medicine，Genome-scale Biology Program, 修了
• 東京水産大学, 大学院水産学研究科修士課程食品生産学専攻, 修了

Academic Resume (Undergraduate School/Majors)

• 東京水産大学, 水産学部食品生産学科, 卒業

Research History

• From Aug. 2026, To Present

  JST創発的支援事業 創発研究者
• From Jan. 2025, To Present

  Kyoto University, Graduate School of Medicine, assistant professor
• From Nov. 2023, To Dec. 2024

  University o Kyoto, Department of molecular oncology, programmed assistant professor
• From May 2022, To Jul. 2023

  ETH Zurich, Institute of Molecular Health Sciences, Postdoc researcher, Overseas Research Fellow (RRA)
• From Apr. 2016, To Oct. 2021

  University of Basel, Department of Biomedicine, Postdoc researcher
• From Aug. 2013, To Mar. 2016

  ETH Zurich, Department of Biosystems Science and Engineering (DBSSE), Postdoc researcher
• From Jan. 2004, To Mar. 2006

  Tokyo Metropolitan University, 理学研究科 化学専攻, Technician
• From Apr. 2003, To Dec. 2003

  日本天然物研究所, 研究開発

ID,URL

• ORCID ID

  0000-0003-0788-2934

• J-Global ID

  202401018993428150

• Researcher number

  30914163

researchmap URL

• https://researchmap.jp/NamiToivo

Research

Research Interests

• Breast cancer, EMT, invasion/metastasis, cell competition, initiation stage of cancer

Research Areas

• Life sciences, Tumor biology, cancer initiation, metastasis, cancer cell plasticity, EMT, cell competition

Papers

• Tracking and characterization of partial and full epithelial-mesenchymal transition cells in a mouse model of metastatic breast cancer

  Fabiana Lüönd; Natascha Santacroce; Christian Beisel; Laurent Guérard; Thomas R. Bürglin; Gerhard Christofori; Nami Sugiyama

  STAR Protocols, Jun. 2022, Last author, Corresponding author

  
• Distinct contributions of partial and full EMT to breast cancer malignancy

  Fabiana Lüönd; Nami Sugiyama; Ruben Bill; Laura Bornes; Carolina Hager; Fengyuan Tang; Natascha Santacroce; Christian Beisel; Robert Ivanek; Thomas Bürglin; Stefanie Tiede; Jacco van Rheenen; Gerhard Christofori

  Developmental Cell, Dec. 2021, Lead author, Corresponding author

  
• Parsing β-catenin’s cell adhesion and Wnt signaling functions in malignant mammary tumor progression

  David Buechel; Nami Sugiyama; Natalia Rubinstein; Meera Saxena; Ravi K. R. Kalathur; Fabiana Lüönd; Vida Vafaizadeh; Tomas Valenta; George Hausmann; Claudio Cantù; Konrad Basler; Gerhard Christofori

  Proceedings of the National Academy of Sciences, 18 Aug. 2021

  
• A Pygopus 2-Histone Interaction Is Critical for Cancer Cell Dedifferentiation and Progression in Malignant Breast Cancer

  Meera Saxena; Ravi K.R. Kalathur; Natalia Rubinstein; Andrea Vettiger; Nami Sugiyama; Melanie Neutzner; Mairene Coto-Llerena; Venkatesh Kancherla; Caner Ercan; Salvatore Piscuoglio; Jonas Fischer; Ernesta Fagiani; Claudio Cantù; Konrad Basler; Gerhard Christofori

  Cancer Research, 01 Sep. 2020

  
• Histone deacetylases, Mbd3/NuRD, and Tet2 hydroxylase are crucial regulators of epithelial–mesenchymal plasticity and tumor metastasis

  Ayse Nihan Kilinc; Nami Sugiyama; Ravi Kiran Reddy Kalathur; Helena Antoniadis; Huseyin Birogul; Dana Ishay-Ronen; Jason T. George; Herbert Levine; Mohit Kumar Jolly; Gerhard Christofori

  Oncogene, 30 Oct. 2019

  
• Gain Fat—Lose Metastasis: Converting Invasive Breast Cancer Cells into Adipocytes Inhibits Cancer Metastasis

  Dana Ishay-Ronen; Maren Diepenbruck; Ravi Kiran Reddy Kalathur; Nami Sugiyama; Stefanie Tiede; Robert Ivanek; Glenn Bantug; Marco Francesco Morini; Junrong Wang; Christoph Hess; Gerhard Christofori

  Cancer Cell, Jan. 2019

  
• Effective Labeling of Primary Somatic Stem Cells with BaTiO₃ Nanocrystals for Second Harmonic Generation Imaging

  Nami Sugiyama; Ali Y. Sonay; Roxanne Tussiwand; Bruce E. Cohen; Periklis Pantazis

  Small, 22 Jan. 2018, Lead author

  
• Actin-associated protein palladin promotes tumor cell invasion by linking extracellular matrix degradation to cell cytoskeleton

  Pernilla von Nandelstadh; Erika Gucciardo; Jouko Lohi; Rui Li; Nami Sugiyama; Olli Carpen; Kaisa Lehti

  Molecular Biology of the Cell, Sep. 2014

  
• EphA2 cleavage by MT1-MMP triggers single cancer cell invasion via homotypic cell repulsion

  Nami Sugiyama; Erika Gucciardo; Olga Tatti; Markku Varjosalo; Marko Hyytiäinen; Matthias Gstaiger; Kaisa Lehti

  Journal of Cell Biology, 29 Apr. 2013, Lead author

  
• KSHV-Initiated Notch Activation Leads to Membrane-Type-1 Matrix Metalloproteinase-Dependent Lymphatic Endothelial-to-Mesenchymal Transition

  Fang Cheng; Pirita Pekkonen; Simonas Laurinavicius; Nami Sugiyama; Stephen Henderson; Thomas Günther; Ville Rantanen; Elisa Kaivanto; Mervi Aavikko; Grzegorz Sarek; Sampsa Hautaniemi; Peter Biberfeld; Lauri Aaltonen; Adam Grundhoff; Chris Boshoff; Kari Alitalo; Kaisa Lehti; Päivi M. Ojala

  Cell Host & Microbe, Dec. 2011

  
• Fibroblast Growth Factor Receptor 4 Regulates Tumor Invasion by Coupling Fibroblast Growth Factor Signaling to Extracellular Matrix Degradation

  Nami Sugiyama; Markku Varjosalo; Pipsa Meller; Jouko Lohi; Marko Hyytiäinen; Sami Kilpinen; Olli Kallioniemi; Signe Ingvarsen; Lars H. Engelholm; Jussi Taipale; Kari Alitalo; Jorma Keski-Oja; Kaisa Lehti

  Cancer Research, 13 Oct. 2010, Lead author

  
• FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane type 1 matrix metalloproteinase–FGFR4 complex

  Nami Sugiyama; Markku Varjosalo; Pipsa Meller; Jouko Lohi; Kui Ming Chan; Zhongjun Zhou; Kari Alitalo; Jussi Taipale; Jorma Keski-Oja; Kaisa Lehti

  Proceedings of the National Academy of Sciences, 23 Aug. 2010, Lead author

  
• Secretion of active membrane type 1 matrix metalloproteinase (MMP‐14) into extracellular space in microvesicular exosomes

  Juha Hakulinen; Lotta Sankkila; Nami Sugiyama; Kaisa Lehti; Jorma Keski‐Oja

  Journal of Cellular Biochemistry, 18 Sep. 2008

  
• Molecular cloning of grammistins, peptide toxins from the soapfish Pogonoperca punctata, by hemolytic screening of a cDNA library

  Tatsuyuki Kaji; Nami Sugiyama; Shoichiro Ishizaki; Yuji Nagashima; Kazuo Shiomi

  Peptides, Dec. 2006

  
• Biological activities of synthetic grammistins and analogous peptides

  Nami SUGIYAMA; Mika ARAKI; Yuji NAGASHIMA; Kazuo SHIOMI

  Fisheries Science, Oct. 2006, Lead author

  
• Further isolation and characterization of grammistins from the skin secretion of the soapfish Grammistes sexlineatus

  Nami Sugiyama; Mika Araki; Masami Ishida; Yuji Nagashima; Kazuo Shiomi

  Toxicon, Apr. 2005, Lead author

  

Misc.

• Eph- and ephrin-dependent mechanisms in tumor and stem cell dynamics.

  Nami Sugiyama

  Cellular and Molecular Life Sciences, 04 May 2014

  
• EphA2 bears plasticity to tumor invasion

  nami sugiyama; Erika Gucciardo; Kaisa Lehti

  Cell Cycle, 15 Sep. 2013

  
• Regulation of the interaction of Disabled‐1 with CIN85 by phosphorylation with Cyclin‐dependent kinase 5

  Yutaka Sato; Masato Taoka; Nami Sugiyama; Ken‐ichiro Kubo; Takahiro Fuchigami; Akiko Asada; Taro Saito; Kazunori Nakajima; Toshiaki Isobe; Shin‐ichi Hisanaga

  Genes to Cells, 07 Dec. 2007

  

Presentations

• Distinct contributions of partial and full of EMT to breast cancer malignancy

  Sugiyama N; Lüönd F; Beisel C; Ivanek R; Bürglin T; Christofori G

  Transregio Regensburg-Erlangen, Symposium TRR 305, 22 May 2023, Invited

  
• Distinct contributions of partial and full of EMT to breast cancer malignancy

  Sugiyama N; Lüönd F; Bill R; Bornes L; Hager C; Tang F; Santacroce N; Beisel C; Ivanek R; Bürglin T; Tiede S; van Rheenen J; Christofori G

  the 10th International Epithelial-Mesenchymal Transition (TEMTIA), 06 Nov. 2022

  
• Distinct roles of partial and full of epithelial-to-mesenchymal transition states in metastasis and chemoresistance of breast cancer

  Sugiyama N; Lüönd F; Bill R; Bornes L; Hager C; Tang F; Santacroce N; Beisel C; Ivanek R; Bürglin T; Tiede S; van Rheenen J; Christofori G

  EMBL Symposium: Defining and defeating metastasis, 21 Jun. 2022

  
• Distinct contributions of partial and full of EMT to breast cancer malignancy

  Sugiyama N; Lüönd F; Beisel C; Ivanek R; Bürglin T; Christofori G

  MRS 19th Biennial Congress, 14 Nov. 2022, Invited

  
• Delineating the different states of the epithelial/mesenchymal spectrum in breast cancer

  Sugiyama N; Lüönd F; Bill R; Bornes L; Hager C; Tang F; Beisel C; Ivanek R; Bürglin T; Tiede S; van Rheenen J; Christofori G

  The International Epithelial-Mesenchymal Transition (TEMTIA) 9.5 Virtual Meeting, 07 Dec. 2021

  
• Distinct roles of partial and full of epithelial-to-mesenchymal transition states in metastasis and chemoresistance of breast cancer

  Sugiyama N; Lüönd F; Bill R; Bornes L; Hager C; Tang F; Santacroce N; Beisel C; Ivanek R; Bürglin T; Tiede S; van Rheenen J; Christofori G

  The 8th Tri-Regio DevStemCell meeting, 30 Sep. 2021

  
• Distinct roles of partial and full of epithelial-to-mesenchymal transition states in metastasis and chemoresistance of breast cancer

  Sugiyama N; Lüönd F; Bill R; Bornes L; Hager C; Tang F; Santacroce N; Beisel C; Ivanek R; Bürglin T; Tiede S; van Rheenen J; Christofori G

  ISREC-SCCL Symposium 2021: Hallmarks of Cancer - 21 Years On, 29 Aug. 2021

  
• Distinct roles of partial and full of epithelial-to-mesenchymal transition states in metastasis and chemoresistance of breast cancer

  Sugiyama N; Lüönd F; Bill R; Bornes L; Hager C; Tang F; Santacroce N; Beisel C; Ivanek R; Bürglin T; Tiede S; van Rheenen J; Christofori G

  30th Cytomeet 2021, 19 Jan. 2021

  
• Distinct Contributions of Partial and Full EMT to Breast Cancer Malignancy

  Lüönd F; Sugiyama N; Hager C; Bill R; Bürglin T; Pelczar P; Christofori G

  Basel Breast Consortium Annual Meeting, 2020, Nov. 2020

  
• Distinct roles of partial and full of epithelial-to-mesenchymal transition states in metastasis and chemoresistance of breast cancer

  Sugiyama N; Lüönd F; Hager C; Bill R; Bürglin T; Pelczar P; Christofori G

  EMBO/EMBL Symposium: Organoids: Modelling Organ Development and Disease in 3D Culture 2020, 21 Oct. 2020

  
• Lineage tracing approach reveals the roles of distinct epithelial-to-mesenchymal transition states in breast cancer malignant progression

  Sugiyama N; Lüönd F; Hager C; Bill R; Bürglin T; Pelczar P; Christofori G

  The 9th International Epithelial-Mesenchymal Transition Meeting, 2019 (TEMTIA-IX), 13 Nov. 2019

  
• The roles of distinct epithelial-to-mesenchymal transition states in drug resistance

  Sugiyama N; Lüönd F; Hager C; Bill R; Pelczar P; Christofori G

  Personalized Oncology, Jun. 2019

  
• EphA2 cleavage by MT1-MMP triggers single cancer cell invasion via homotypic cell repulsion.

  Sugiyama N; Gucciardo E; Tatti O; Varjosalo M; Hyytiäinen M; Gstaiger M; Lehti K

  EMBO Conference Series “Morphogenesis and Dynamics of Multicellular Systems, Oct. 2012

  
• Metalloproteinase cleavage of EphA2 regulates cell-cell repulsion and single cell invasion

  Sugiyama N; Gucciardo E; von Nandelstadh P; Tatti O; Varjosalo M; Hyytiäinen M; Gstaiger M; Lehti K

  7th Abercrombie Meeting, Jul. 2012

  
• Identification of unique co-operative interactions of membrane-type-1 matrix metalloproteinase and signalling receptors in tumour cell invasion

  Sugiyama N; Varjosalo M; Meller P; Lohi J; Chan K.M; Zhou Z; Alitalo K; Taipale J; Keski-Oja J; Lehti K

  The 5th International Epithelial-Mesenchymal Transition Meeting, 2011 (TEMTIA-V), Nov. 2011

  
• Identification of unique co-operative interactions of membrane-type-1 matrix metalloproteinase and signalling receptors in tumour cell invasion.

  Sugiyama N; Varjosalo M; Meller P; Lohi J; Chan K.M; Zhou Z; Alitalo K; Taipale J; Keski-Oja J; Lehti K

  ISREC MEETING "Hallmarks & Horizons of Cancer", Oct. 2011

  
• FGF receptor-4 polymorphism acts as an activity switch of a membrane-type-1 matrix metalloproteinase-FGFR4 complex

  Sugiyama N; Varjosalo M; Meller P; Lohi J; Chan K.M; Zhou Z; Alitalo K; Taipale J; Keski-Oja J; Lehti K

  Nature - CNIO Cancer Symposium on "Frontiers in Tumour Progression", Oct. 2010

  
• MT1-MMP/FGFR4 axis regulates tumor invasion by coupling FGF-signaling to pericellular proteolysis

  Sugiyama N; Varjosalo M; Meller P; Hyytiäinen M; Ingvarsen S; Engelholm LH; Lohi J; Alitalo K; Taipale J; Keski-Oja J; Lehti K

  AACR special conference on EMT and Cancer Progression and Treatment, 28 Feb. 2010

  
• MT1-MMP/FGFR4 axis regulates tumor invasion by coupling FGF-signaling to pericellular proteolysis.

  Sugiyama N; Varjosalo M; Meller P; Lohi J; Hyytiäinen M; Kilpinen S; Kallioniemi O; Ingvarsen S; Engelholm LH; Taipale J; Alitalo K; Keski-Oja J; Lehti K

  Matrix Metalloproteinase Meeting of Gordon Research Conferences, 01 Sep. 2009

  
• FGFR4 regulates tumor invasion by coupling FGF-signaling to pericellular proteolysis

  Sugiyama N; Varjosalo M; Meller P; Lohi J; Hyytiäinen M; Ingvarsen S; Engelholm LH; Taipale J; Alitalo K; Keski-Oja J; Lehti K

  The 19th Annual BioCity Symposium and the 9th Symposium of Finnish Cancer Institute on Tumor Microenvironment in Cancer Progression, Sep. 2009

  
• Use of gain-of-function kinome screen to identify the regulatory mechanisms of MT1-MMP driven cancer cell invasion

  Sugiyama N; Varjosalo M; Taipale J; Keski-Oja J; Lehti K

  XXIst Meeting of the Federation of the European Connective Tissue Society (FECTS), Jul. 2008

  
• Identification of novel signaling mediators in membrane-type 1 matrix metalloproteinase (MT1-MMP) regulation in cancer cells

  Sugiyama N; Varjosalo M; Taipale J; Keski-Oja J; Lehti K

  5th General Meeting of the International Proteolysis Society, Nov. 2007

  

Awards

• 04 Sep. 2009

  ポスター賞（Matrix Metalloproteinase Meeting of Gordon Research Conferences）
• 13 Nov. 2020

  ポスター賞（Basel Breast Consortium Annual Meeting）
• 21 Aug. 2009

  ポスター賞（19th Annual Bio City Symposium）
• 14 Nov. 2019

  ポスター賞（9th International Epithelial-Mesenchymal Transition Meeting）

External funds: Kakenhi

• 細胞競合と代謝リプログラミングの連携によるHER2陽性乳がん発症機構の解明

  Grant-in-Aid for Early-Career Scientists

  Basic Section 50010:Tumor biology-related

  Kyoto University

  杉山 奈美

  From 01 Apr. 2026, To 31 Mar. 2029, Granted

  乳がん超初期;Her2;細胞競合モデルマウス;代謝リプログラミング

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26K18677/
• 細胞競合モデルマウスを用いたHer2による乳がん初期過程のメカニズムの解明

  Grant-in-Aid for Research Activity Start-up

  0901:Oncology and related fields

  Kyoto University

  杉山 奈美

  From 31 Jul. 2024, To 31 Mar. 2026, Granted

  乳がん超初期;Her2;細胞競合モデルマウス;がん微小環境;がん超初期;細胞競合;乳がん

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K23350/

Education

Teaching subject(s)

• From 01 Apr. 2026, To 31 Mar. 2027

  Global Frontier in Life Science A

  1018, Spring, Graduate School of Biostudies, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Global Frontier in Life Science A

  1018, Spring, Graduate School of Biostudies, 2