Basic Information

Professional Memberships

• International Chemical Biology Society
• The Japanese Society for Virology
• The Japan Society of Hepatology
• Japanese Society for Chemical Biology
• The Japanese Pharmacological Society
• The Molecular Biology Society of Japan

Academic Degree

• 修士（理学）(名古屋大学)
• 博士（理学）(名古屋大学)

Academic Resume (Graduate Schools)

• 名古屋大学, 大学院理学研究科分子生物学専攻(５年一貫課程), 修了

Academic Resume (Undergraduate School/Majors)

• 名古屋大学, 理学部分子生物学科, 卒業

Research History

• From 01 Apr. 2018

  -, -
• From 01 Apr. 2011

  Graduate School of Medicine, Kyoto University, Research Assistant Professor
• From 16 May 2007

  Graduate School of Biomedical Science, Tokyo Medical and Dental University, Research Assistant Professor
• From 01 Apr. 2006

  Department of Biological Science, Graduate School of Sciences, Nagoya University, Research Fellow
• From 01 Jul. 2005

  Graduate School of Frontier Biosciences, Osaka University, Assistant Professor
• From 01 Apr. 2005

  Graduate School of Frontier Biosciences, Osaka University, Research Fellow
• From Feb. 2003, To Mar. 2005

  Nagoya University, Division of Biological Science, Graduate School of Sciences,, Assistant Professor
• From Jun. 2002, To Feb. 2003

  ニューヨーク州立大学 Upstate Medical University
• From May 1998, To May 2002

  SUNY Upstate Medical University, artment of Biochemistry and Molecular Biology, Post-doctoral Associate

Language of Instruction

• Japanese
• English

ID,URL

• ORCID ID

  0000-0002-3788-1513

• J-Global ID

  201401022040833392

researchmap URL

• https://researchmap.jp/7000009130

Research

Research Areas

• Life sciences, Pharmaceuticals - chemistry and drug development, Chemical Biology
• Life sciences, Molecular biology

Papers

• Structural analysis shows the mode of inhibition for Staphylococcus aureus lipase by antipsychotic penfluridol

  Julia Kitadokoro; Takatsugu Hirokawa; Masayuki Kamo; Naoki Furubayashi; Yukiko Okuno; Takaaki Hikima; Masaki Yamamoto; Koji Inaka; Katsumi Maenaka; Shigeki Kamitani; Kengo Kitadokoro

  Scientific Reports, 14 Apr. 2025

  
• Crystal structure of Staphylococcus aureus lipase complex with unsaturated petroselinic acid

  Julia Kitadokoro; Shigeki Kamitani; Yukiko Okuno; Takaaki Hikima; Masaki Yamamoto; Takatsugu Hirokawa; Kengo Kitadokoro

  FEBS Open Bio, 16 May 2024

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• Newly developed preclinical models reveal broad-spectrum CDK inhibitors as potent drugs for CRPC exhibiting primary resistance to enzalutamide.

  Takashi Matsuoka; Aiko Sugiyama; Yoshifumi Miyawaki; Yusuke Hidaka; Yukiko Okuno; Hiroaki Sakai; Hiroki Tanaka; Kiyotsugu Yoshikawa; Tomohiro Fukui; Kei Mizuno; Takayuki Sumiyoshi; Takayuki Goto; Takahiro Inoue; Shusuke Akamatsu; Takashi Kobayashi; Eijiro Nakamura

  Cancer science, 03 Nov. 2023

  
• 最先端医療の今 抗肥満薬が黄色ブドウ球菌の病原因子を阻害するメカニズムを解明

  北所 健悟; 奥野 友紀子; 引間 孝明; 山本 雅貴; 神谷 重樹

  Medical Science Digest, Oct. 2023

  
• Cryptotanshinone is a candidate therapeutic agent for interstitial lung disease associated with a BRICHOS-domain mutation of SFTPC

  Motoyasu Hosokawa; Ryuta Mikawa; Atsuko Hagiwara; Yukiko Okuno; Tomonari Awaya; Yuki Yamamoto; Senye Takahashi; Haruka Yamaki; Mitsujiro Osawa; Yasuhiro Setoguchi; Megumu K. Saito; Shinji Abe; Toyohiro Hirai; Shimpei Gotoh; Masatoshi Hagiwara

  iScience, Aug. 2023

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• High-throughput Screening in Combination With a Cohort Study for Iodothyronine Deiodinases

  Ichiro Yamauchi; Yoriko Sakane; Yukiko Okuno; Taku Sugawa; Takuro Hakata; Haruka Fujita; Kentaro Okamoto; Daisuke Taura; Takafumi Yamashita; Keisho Hirota; Yohei Ueda; Toshihito Fujii; Akihiro Yasoda; Nobuya Inagaki

  Endocrinology, 01 Aug. 2022, Peer-reviewed

  
• Albendazole induces the terminal differentiation of acute myeloid leukaemia cells to monocytes by stimulating the Krüppel‐like factor 4‐dihydropyrimidinase‐like 2A (KLF4‐DPYSL2A) axis

  Mina Noura; Ken Morita; Hiroki Kiyose; Yukiko Okuno; Hidemasa Matsuo; Asami Koyama; Yoko Nishinaka‐Arai; Yasuhiko Kamikubo; Souichi Adachi

  British Journal of Haematology, Aug. 2021, Peer-reviewed

  
• Crystal structure of pathogenic Staphylococcus aureus lipase complex with the anti-obesity drug orlistat.

  Kengo Kitadokoro; Mutsumi Tanaka; Takaaki Hikima; Yukiko Okuno; Masaki Yamamoto; Shigeki Kamitani

  Scientific reports, 25 Mar. 2020, Peer-reviewed

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• RBM24 promotes U1 snRNP recognition of the mutated 5 ' splice site in the IKBKAP gene of familial dysautonomia

  Kenji Ohe; Mayumi Yoshida; Akiko Nakano-Kobayashi; Motoyasu Hosokawa; Yukiya Sako; Maki Sakuma; Yukiko Okuno; Tomomi Usui; Kensuke Ninomiya; Takayuki Nojima; Naoyuki Kataoka; Masatoshi Hagiwara

  RNA, Sep. 2017, Peer-reviewed

  
• Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice

  Akiko Nakano-Kobayashi; Tomonari Awaya; Isao Kii; Yuto Sumida; Yukiko Okuno; Suguru Yoshida; Tomoe Sumida; Haruhisa Inoue; Takamitsu Hosoya; Masatoshi Hagiwara

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Sep. 2017, Peer-reviewed

  
• Retinoid derivative Tp80 exhibits anti-hepatitis C virus activity through restoration of GI-GPx expression

  Bao Ngoc Nguyen; Yukiko Okuno; Masahiko Ajiro; Kei Iida; Masatsugu Denawa; Makoto Yamamoto; Naoya Sakamoto; Hiroyuki Kagechika; Masatoshi Hagiwara

  JOURNAL OF MEDICAL VIROLOGY, Jul. 2017, Peer-reviewed

  
• In vitro expansion of mouse primordial germ cell-like cells recapitulates an epigenetic blank slate.

  Ohta H; Kurimoto K; Okamoto I; Nakamura T; Yabuta Y; Miyauchi H; Yamamoto T; Okuno Y; Hagiwara M; Shirane K; Sasaki H; Saitou M

  The EMBO journal, May 2017, Peer-reviewed

  
• Development of an orally available inhibitor of CLK1 for skipping a mutated dystrophin exon in Duchenne muscular dystrophy

  Yukiya Sako; Kensuke Ninomiya; Yukiko Okuno; Masayasu Toyomoto; Atsushi Nishida; Yuka Koike; Kenji Ohe; Isao Kii; Suguru Yoshida; Naohiro Hashimoto; Takamitsu Hosoya; Masafumi Matsuo; Masatoshi Hagiwara

  SCIENTIFIC REPORTS, May 2017, Peer-reviewed

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• Establishment of Nephrin Reporter Mice and Use for Chemical Screening

  Junichi Tsuchida; Taiji Matsusaka; Masato Ohtsuka; Hiromi Miura; Yukiko Okuno; Katsuhiko Asanuma; Takahiko Nakagawa; Motoko Yanagita; Kiyoshi Mori

  PLOS ONE, Jun. 2016, Peer-reviewed

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• Selective inhibition of the kinase DYRK1A by targeting its folding process

  Isao Kii; Yuto Sumida; Toshiyasu Goto; Rie Sonamoto; Yukiko Okuno; Suguru Yoshida; Tomoe Kato-Sumida; Yuka Koike; Minako Abe; Yosuke Nonaka; Teikichi Ikura; Nobutoshi Ito; Hiroshi Shibuya; Takamitsu Hosoya; Masatoshi Hagiwara

  NATURE COMMUNICATIONS, Apr. 2016, Peer-reviewed

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• Identification of a Dual Inhibitor of SRPK1 and CK2 That Attenuates Pathological Angiogenesis of Macular Degeneration in Mice

  Satoshi Morooka; Mitsuteru Hoshina; Isao Kii; Takayoshi Okabe; Hirotatsu Kojima; Naoko Inoue; Yukiko Okuno; Masatsugu Denawa; Suguru Yoshida; Junichi Fukuhara; Kensuke Ninomiya; Teikichi Ikura; Toshio Furuya; Tetsuo Nagano; Kousuke Noda; Susumu Ishida; Takamitsu Hosoya; Nobutoshi Ito; Nagahisa Yoshimura; Masatoshi Hagiwara

  MOLECULAR PHARMACOLOGY, Aug. 2015, Peer-reviewed

  
• Identification of a DYRK1A Inhibitor that Induces Degradation of the Target Kinase using Co-chaperone CDC37 fused with Luciferase nanoKAZ

  Rie Sonamoto; Isao Kii; Yuka Koike; Yuto Sumida; Tomoe Kato-Sumida; Yukiko Okuno; Takamitsu Hosoya; Masatoshi Hagiwara

  SCIENTIFIC REPORTS, Aug. 2015, Peer-reviewed

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• Rectifier of aberrant mRNA splicing recovers tRNA modification in familial dysautonomia

  Mayumi Yoshida; Naoyuki Kataoka; Kenjyo Miyauchi; Kenji Ohe; Kei Iida; Suguru Yoshida; Takayuki Nojima; Yukiko Okuno; Hiroshi Onogi; Tomomi Usui; Akihide Takeuchi; Takamitsu Hosoya; Tsutomu Suzuki; Masatoshi Hagiwaraa

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Mar. 2015, Peer-reviewed

  
• SRPK1をターゲットとした化合物スクリーニングによる新規血管新生阻害薬の開発

  諸岡諭; 保科光輝; 喜井勲; 奥野友紀子; 吉田優; 伊藤暢聡; 細谷孝允; 吉村長久; 萩原正敏

  血管, 2015, Peer-reviewed

  
• Discovery of Protein Disulfide Isomerase P5 Inhibitors that Reduce the Secretion of MICA from Cancer Cells

  Tomohisa Horibe; Aya Torisawa; Yukiko Okuno; Koji Kawakami

  CHEMBIOCHEM, Jul. 2014, Peer-reviewed

  
• Identification of Novel N-(Morpholine-4-Carbonyloxy) Amidine Compounds as Potent Inhibitors against Hepatitis C Virus Replication

  Akiko Kusano-Kitazume; Naoya Sakamoto; Yukiko Okuno; Yuko Sekine-Osajima; Mina Nakagawa; Sei Kakinuma; Kei Kiyohashi; Sayuri Nitta; Miyako Murakawa; Seishin Azuma; Yuki Nishimura-Sakurai; Masatoshi Hagiwara; Mamoru Watanabe

  ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Mar. 2012, Peer-reviewed

  
• Cell-based chemical screen identifies a novel type of kinase inhibitor that targets autophosphorylation of the kinase DYRK1A

  Kii Isao; Okuno Yukiko; Sumida Yuto; Hosoya Takamitsu; Hagiwara Masatoshi

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012, Peer-reviewed

  
• The Kinase Inhibitor SFV785 Dislocates Dengue Virus Envelope Protein from the Replication Complex and Blocks Virus Assembly

  Azlinda Anwar; Takamitsu Hosoya; Kok Mun Leong; Hiroshi Onogi; Yukiko Okuno; Toshiyuki Hiramatsu; Hiroko Koyama; Masaaki Suzuki; Masatoshi Hagiwara; Mariano A. Garcia-Blanco

  PLOS ONE, Aug. 2011, Peer-reviewed

  
• A cell-based assay to screen stimulators of the Hippo pathway reveals the inhibitory effect of dobutamine on the YAP-dependent gene transcription

  Yijun Bao; Kentaro Nakagawa; Zeyu Yang; Mitsunobu Ikeda; Kanchanamala Withanage; Mari Ishigami-Yuasa; Yukiko Okuno; Shoji Hata; Hiroshi Nishina; Yutaka Hata

  JOURNAL OF BIOCHEMISTRY, Aug. 2011, Peer-reviewed

  
• The DNA polymerase activity of Pol ε holoenzyme is required for rapid and efficient chromosomal DNA replication in Xenopus egg extracts

  Koh Shikata; Taro Sasa-Masuda; Yukiko Okuno; Shou Waga; Akio Sugino

  BMC Biochemistry, 22 Aug. 2006, Peer-reviewed

  
• The Chinese hamster dihydrofolate reductase replication origin decision point follows activation of transcription and suppresses initiation of replication within transcription units

  T Sasaki; S Ramanathan; Y Okuno; C Kumagai; SS Shaikh; DA Gilbert

  MOLECULAR AND CELLULAR BIOLOGY, Feb. 2006, Peer-reviewed

  
• Chinese hamster ORC subunits dynamically associate with chromatin throughout the cell-cycle

  AJ McNairn; Y Okuno; T Misteli; DM Gilbert

  EXPERIMENTAL CELL RESEARCH, Aug. 2005, Peer-reviewed

  
• RB reversibly inhibits DNA replication via two temporally distinct mechanisms

  SP Angus; CN Mayhew; DA Solomon; WA Braden; MP Markey; Y Okuno; MC Cardoso; DM Gilbert; ES Knudsen

  MOLECULAR AND CELLULAR BIOLOGY, Jun. 2004, Peer-reviewed

  
• Structure of a palindromic amplicon junction implicates microhomology-mediated end joining as a mechanism of sister chromatid fusion during gene amplification

  Y Okuno; PJ Hahn; DM Gilbert

  NUCLEIC ACIDS RESEARCH, Jan. 2004, Peer-reviewed

  
• Stability, chromatin association and functional activity of mammalian pre-replication complex proteins during the cell cycle

  Y Okuno; AJ McNairn; N den Elzen; J Pines; DM Gilbert

  EMBO JOURNAL, Aug. 2001, Peer-reviewed

  
• Clustered adenine/thymine stretches are essential for function of a fission yeast replication origin

  Y Okuno; H Satoh; M Sekiguchi; H Masukata

  MOLECULAR AND CELLULAR BIOLOGY, Oct. 1999, Peer-reviewed

  
• Identification of a predominant replication origin in fission yeast

  Y Okuno; T Okazaki; H Masukata

  NUCLEIC ACIDS RESEARCH, Feb. 1997, Peer-reviewed

  
• A replication-enhancing element with transcriptional silencer activity in autonomously replicating human chromosomal fragments

  C Obuse; Y Okuno; T Okazaki; H Masukata

  MOLECULAR BIOLOGY OF THE CELL, Jan. 1996, Peer-reviewed

  

Misc.

• Mechanism of inhibition of Staphylococcus aureus virulence factor by anti-obesity drugs

  北所健悟; 奥野友紀子; 引間孝明; 山本雅貴; 神谷重樹

  月刊メディカル・サイエンス・ダイジェスト, 2023

  
• 神経新生促進によるダウン症モデルにおける脳発達障害の是正

  小林 亜希子; 粟屋 智就; 喜井 勲; 隅田 有人; 奥野 友紀子; 和根崎 圭子; 吉田 優; 隅田 ともえ; 井上 治久; 細谷 孝充; 萩原 正敏

  生命科学系学会合同年次大会, Dec. 2017

  
• 小胞体でのミスフォールドタンパク質蓄積に伴うレドックス異常回復剤の同定とその機序について

  奥勇紀; 奥野友紀子; 萩原正敏; 寳関淳; 寳関淳; 阪井康能; 阪井康能

  日本農芸化学会大会講演要旨集(Web), 2017

  
• 神経新生促進によるダウン症モデルにおける脳発達障害の是正

  小林亜希子; 粟屋智就; 喜井勲; 隅田有人; 奥野友紀子; 和根崎圭子; 吉田優; 隅田ともえ; 井上治久; 細谷孝充; 萩原正敏

  日本生化学会大会(Web), 2017

  
• 小胞体における異常タンパク質蓄積に伴うレドックス変化とこれを回復させる薬剤探索系の開発

  寳関淳; 寳関淳; 奥勇紀; 藤村多嘉朗; 大石麻水; 奥野友紀子; 萩原正敏; 阪井康能; 阪井康能

  日本細胞生物学会大会(Web), 2016

  
• Identification of a dual inhibitor of SRPK1 and CK2 that attenuates pathological angiogenesis of macular degeneration in mice

  Satoshi Morooka; Isao Kii; Yukiko Okuno; Nobutoshi Ito; Masatoshi Hagiwara; Nagahisa Yoshimura

  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Jun. 2015

  
• SRPK1およびCK2阻害活性を有する新規血管新生阻害薬の開発

  諸岡 諭; 喜井 勲; 奥野 友紀子; 吉田 優; 福原 淳一; 野田 航介; 伊藤 暢聡; 石田 晋; 細谷 孝充; 萩原 正敏; 吉村 長久

  日本眼科学会雑誌, 2015

  
• リン酸化酵素DYRK1Aのフォールディング中間体を標的とした新規阻害剤の開発

  喜井勲; 奥野友紀子; 隅田有人; 後藤利保; 吉田優; 澁谷浩司; 安倍美奈子; 伊藤暢聡; 細谷孝充; 萩原正敏

  日本薬理学会近畿部会プログラム・要旨集, 2014

  
• 抗C型肝炎ウイルス能をもつ低分子化合物の同定

  奥野友紀子; NGUYEN Bao Ngoc; NGUYEN Bao Ngoc; 飯田慶; 出縄政嗣; 坂本直哉; 影近弘之; 萩原正敏

  日本ウイルス学会学術集会プログラム・抄録集, 2013

  
• PINK1/parkin pathwayにおける機能調節低分子化合物の網羅的解析

  張長亮; 奥野友紀子; 萩原正敏; 高橋良輔

  日本神経学会学術大会プログラム・抄録集, 2013

  
• Antiviral effetcts and action mechanisms of novel N-(morpholine-4-carbonyloxy) amidine compounds against hepatitis C virus

  Akiko Kusano-Kitazume; Naoya Sakamoto; Yukiko Okuno; Kenichi Mori; Mina Nakagawa; Sei Kakinuma; Sayuri Nitta; Miyako Murakawa; Seishin Azuma; Yuki Nishimura-Sakurai; Akihiro Matsumoto; Masatoshi Hagiwara; Yasuhiro Asahina; Mamoru Watanabe

  HEPATOLOGY, Oct. 2012

  
• 抗HCV活性を有するN-(morpholine-4-carbonyloxy)amidine化合物の同定

  北詰晶子; 坂本直哉; 奥野友紀子; 中川美奈; 中川美奈; 柿沼晴; 柿沼晴; 幾世橋佳; 新田沙由梨; 村川美也子; 東正新; 櫻井幸; 萩原正敏; 渡辺守

  肝臓, 2012

  
• パーキンソン病におけるPINK1/Parkin及びミトコンドリア機能調節低分子化合物の網羅的解析

  張長亮; 奥野友紀子; 萩原正敏; 高橋良輔

  パーキンソン病・運動障害疾患コングレスプログラム・抄録集, 2012

  
• Development of novel SRPK inhibitors based on the Structural Analysis

  Yukiko Okuno; Mitsuteru Hoshina; Hiroshi Onogi; Yosuke Nonaka; Keiko Tsuchihashi; Takamitsu Hosoya; Teikichi Ikura; Nobutoshi Ito; Masatoshi Hagiwara

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012

  
• A HIGH-CONTENT SCREENING ASSAY USING INFECTIOUS FLUORESCENCE-TAGGED HEPATITIS C VIRUS REVEALS CANDIDATES FOR SMALL MOLECULE INHIBITORS OF VIRAL ENTRY

  Akiko Kusano-Kitazume; Naoya Sakamoto; Yukiko Okuno; Machi Yamamoto; Yuko Sekine-Osajima; Mina Nakagawa; Sei Kakinuma; Kei Kiyohashi; Sayuri Nitta; Miyako Murakawa; Masatoshi Hagiwara; Mamoru Watanabe

  HEPATOLOGY, Oct. 2011

  
• 蛍光蛋白発現HCV培養系を用いたHigh-content screening assayの樹立及びHCVエントリー阻害剤探索への応用

  北詰晶子; 坂本直哉; 坂本直哉; 奥野友紀子; 筬島裕子; 中川美奈; 中川美奈; 柿沼晴; 柿沼晴; 植山真由美; 小野塚泉; 船岡祐介; 渡辺貴子; 幾世橋佳; 新田沙由梨; 村川美也子; 萩原正敏; 渡辺守

  肝臓, 2011

  
• Cell based high-throughput screeningによる新規抗ウイルス小分子の同定及びその作用機構の解析

  北詰晶子; 坂本直哉; 坂本直哉; 奥野友紀子; 筬島裕子; 中川美奈; 中川美奈; 柿沼晴; 柿沼晴; 植山真由美; 小野塚泉; 船岡祐介; 渡辺貴子; 幾世橋佳; 新田沙由梨; 村川美也子; 萩原正敏; 渡辺守

  肝臓, 2011

  
• EYFP発現HCV培養系を用いたHigh-content screening assayによるウイルス侵入阻害剤の同定

  北詰晶子; 坂本直哉; 坂本直哉; 奥野友紀子; 中川美奈; 中川美奈; 柿沼晴; 柿沼晴; 山本満千; 幾世橋佳; 新田沙由梨; 村川美也子; 萩原正敏; 渡辺守

  肝臓, 2011

  
• ケミカルスクリーニング推進に向けた基盤構築

  湯浅(石上)磨里; 奥野友紀子; 渡辺由紀子; 萩原正敏

  日本薬理学会関東部会プログラム・要旨集, 2009

  
• 分裂酵母染色体複製開始点の機能構造解析

  山田慶昭; 奥野友紀子; 升方久夫

  日本分子生物学会年会プログラム・講演要旨集, 2000

  
• 分裂酵母ORCはARS活性に必須のアデニン連続配列に結合する

  高橋達郎; 浅原貴之; 奥野友紀子; 升方久夫

  日本分子生物学会年会プログラム・講演要旨集, 1999

  
• 分裂酵母染色体複製開始点の機能構造解析

  山田慶昭; 奥野友紀子; 升方久夫

  日本分子生物学会年会プログラム・講演要旨集, 1999

  
• 試験管内における分裂酵母ORCと複製開始点の相互作用の解析

  高橋達郎; 奥野友紀子; 浅原貴之; 升方久夫

  日本分子生物学会年会プログラム・講演要旨集, 1998

  
• In vivo footprinting of DNA-protein complex on a replication origin in fission yeast.

  奥野友紀子; 高橋達郎; 島弘季; 升方久夫

  日本分子生物学会年会プログラム・講演要旨集, 1997

  
• Interaction of ORC complex with a replication origin in fission yeast.

  高橋達郎; 島弘季; 奥野友紀子; 升方久夫

  日本分子生物学会年会プログラム・講演要旨集, 1997

  
• Duplicate indispensable sequence of fission yeast.

  奥野友紀子; 佐藤広泰; 小川裕也; 升方久夫

  日本分子生物学会年会プログラム・講演要旨集, 1996

  
• Structual analysis of replication initiating point of fission yeast S.pombe.

  奥野友紀子; 佐藤広泰; 小川裕也; 升方久夫

  日本分子生物学会年会プログラム・講演要旨集, 1996

  
• Replication Origin in Fission Yeast.

  奥野友紀子; 佐藤広泰; 升方久夫

  日本分子生物学会年会プログラム・講演要旨集, 1995

  
• Replication origin in fission yeast.

  升方久夫; 奥野友紀子; 佐藤広泰; 小川裕也

  日本分子生物学会年会プログラム・講演要旨集, 1995

  
• Nucleotide Sequences that Enhance Autonomous Replication in Human Cells Have Transcriptional Activity in Human Cells.

  小布施力史; 奥野友紀子; 升方久夫

  日本分子生物学会年会プログラム・講演要旨集, 1994

  
• Replication Origin in Human Cells and Fission Yeast.

  升方久夫; 小布施力史; 佐藤広泰; 小川裕也; 奥野友紀子

  日本分子生物学会年会プログラム・講演要旨集, 1994

  
• Structure of Replication Origin in Fission Yeast.

  佐藤広泰; 奥野友紀子; 小川裕也; 升方久夫

  日本分子生物学会年会プログラム・講演要旨集, 1994

  
• Replication Origin in Fission Yeast.

  奥野友紀子; 佐藤広泰; 小川裕也; 升方久夫

  日本分子生物学会年会プログラム・講演要旨集, 1994

  
• ヒトARS断片の複製に関与する塩基配列

  升方久夫; 小布施力史; 佐藤広泰; 小川裕也; 奥野友紀子; 岡崎恒子

  日本分子生物学会年会プログラム・講演要旨集, 1993

  
• ヒトARSプラスミドpUCW1の複製効率に関与する塩基配列の解析

  小布施力史; 升方久夫; 奥野友紀子; 岡崎恒子

  日本分子生物学会年会プログラム・講演要旨集, 1993

  

External funds: Kakenhi

• Therapeutic Drug Discovery and Elucidation of RNA Disease Pathogenesis by Use of CRISPR-Based Disease iPS Cells and Animal Models

  Grant-in-Aid for Scientific Research (S)

  Kyoto University

  Masatoshi Hagiwara

  From 29 May 2015, To 31 Mar. 2020, Project Closed

  遺伝性疾患;スプライシング制御;ポストゲノム創薬;遺伝子性疾患;スプライシング介入ルール;RNA病;トランスクリプトーム解析;モデルトランスクリプトーム解析;RNA病モデル;トランスクリプトーム;kibans;CRISPR;iPS;スプライシング

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H05721/
• トランスクリプトームの人為的操作による遺伝病の治療

  Grant-in-Aid for Scientific Research (A)

  Kyoto University

  萩原 正敏

  From 01 Apr. 2015, To 31 Mar. 2016, Discontinued

  創薬;CRISPR;iPS;スプライシング

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H02505/
• DNAポリメラーゼεミューテーター変異マウスの構築とその発がん機構の解析

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Osaka University

  杉野 明雄

  From 01 Apr. 2005, To 31 Mar. 2006, Project Closed

  DNAポリメラーゼε;遺伝学;癌;マウスES細胞;ミューテーター

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17013056/
• ほ乳細胞における複製開始点の同定とその制御機構の解析

  Grant-in-Aid for Young Scientists (B)

  Osaka University;Nagoya University

  奥野 友紀子

  From 01 Apr. 2004, To 31 Mar. 2006, Project Closed

  DNA複製;複製タイミング;複製開始点;マウスゲノム;Fluorescence in situ Hybridization;ヒト人工染色体

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16710140/
• 真核生物染色体DNA複製フォークの分子ダイナミズム

  Grant-in-Aid for Scientific Research (S)

  Osaka University

  杉野 明雄

  From 01 Apr. 2003, To 31 Mar. 2007, Project Closed

  染色体複製;DNAポリメラーゼ;アフリカツメガエル;出芽酵母;哺乳動物細胞;チェックポイント;In vitro DNA複製;ほ乳動物細胞;pre RC(複製開始前複合体);Mcm蛋白;Cdc;Db4f protein kinase;GINS;Polε複合体;アフリカツメガエル卵粗抽出液;セントロメア;複製開始;pre RC (複製開始名複合体);Dbf4 protein kinase

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15107003/
• A Comprehensive Amino Acid Transporter-Based Therapeutic Strategy for Lethal Prostate Cancer

  Grant-in-Aid for Scientific Research (B)

  Basic Section 56030:Urology-related

  Chiba University

  坂本 信一

  From 01 Apr. 2024, To 31 Mar. 2027, Granted

  アミノ酸トランスポーター;致死性前立腺癌;エクソソーム;去勢抵抗性前立腺癌;神経内分泌前立腺癌

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K02575/

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  Practicum on Medical Research

  E065, Year-long, Graduate School of Medicine, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Practicum on Medical Research

  E065, Year-long, Graduate School of Medicine, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Practicum on Medical Research

  E065, Year-long, Graduate School of Medicine, 2
• From Apr. 2014, To Mar. 2015

  Practicum on Medical Research

  Year-long, 医学研究科
• From Apr. 2015, To Mar. 2016

  Practicum on Medical Research

  Year-long, 医学研究科
• From Apr. 2016, To Mar. 2017

  Practicum on Medical Research

  Year-long, 医学研究科
• From Apr. 2017, To Mar. 2018

  Practicum on Medical Research

  Year-long, 医学研究科
• From Apr. 2018, To Mar. 2019

  Practicum on Medical Research

  Year-long, 医学研究科
• From Apr. 2019, To Mar. 2020

  Practicum on Medical Research

  Year-long, 医学研究科
• From Apr. 2020, To Mar. 2021

  Practicum on Medical Research

  Year-long, 医学研究科
• From Apr. 2021, To Mar. 2022

  Practicum on Medical Research

  Year-long, 医学研究科

Administration

Faculty management (title, position)

• From 01 Apr. 2023, To 31 Mar. 2025

  医学・生命科学研究支援機構（iSAL）運営委員会委員