Basic Information

Faculty

• Faculty of Agriculture

Email Address

• Email Address

  takaoka.yousuke.2ckyoto-u.ac.jp

Professional Memberships

• 日本農芸化学会
• 日本ケミカルバイオロジー学会
• 植物調節学会
• 日本化学会

Academic Degree

• 26 Mar. 2007

  九州大学修士（工学）
• 23 Mar. 2010

  京都大学博士（工学）

Academic Resume (Graduate Schools)

• 京都大学, 大学院工学研究科博士後期課程合成･生物化学専攻, 修了
• 九州大学, 大学院工学府物質創造工学専攻修士課程, 修了

Academic Resume (Undergraduate School/Majors)

• 九州大学, 工学部物質科学工学科, 卒業

Research History

• From Apr. 2025, To Present

  Kyoto University, Graduate School of Agriculture, Professor
• From Apr. 2020, To Mar. 2025

  Tohoku University, Graduate School of Science Department of Chemistry, Associate Professor
• From Oct. 2016, To Mar. 2020

  Japan Science and Technology Agency, さきがけ研究員
• From Jul. 2014, To Mar. 2020

  Tohoku University, Graduate School of Science Department of Chemistry, Junior Associate Professor
• From Feb. 2010, To Jun. 2014

  Kyoto University, Graduate School of Engineering Department of Synthetic Chemistry and Biological Chemistry, Assistant Professor
• From Apr. 2010, To Oct. 2010

  日本学術振興会特別研究員(PD), 東京大学大学院医学系研究科, PD

ID,URL

• ORCID ID

  0000-0003-1559-4924

• J-Global ID

  201501026441527572

• Researcher number

  80599762

• External link

  https://sites.google.com/view/ku-biofunction

researchmap URL

• https://researchmap.jp/7000010899

Research

Research Interests

• Chemical Biology

Research Areas

• Nanotechnology/Materials, Chemical biology
• Life sciences, Bioorganic chemistry

Papers

• A structure-redesigned intrinsically disordered peptide that selectively inhibits a plant transcription factor in jasmonate signaling

  Yousuke Takaoka; Ruiqi Liu; Minoru Ueda

  PNAS Nexus, 26 Jul. 2024

  
• Downstream metabolites of (+)-cis-12-oxo-phytodienoic acid function as noncanonical bioactive jasmonates inArabidopsis thaliana

  Rina Saito; Yuho Nishizato; Tsumugi Kitajima; Misuzu Nakayama; Yousuke Takaoka; Nobuki Kato; Minoru Ueda

  03 May 2024

  
• Two distinct modes of action of molecular glues in the plant hormone co-receptor COI1-JAZ system

  Takuya Kaji; Kotaro Matsumoto; Taichi Okumura; Misuzu Nakayama; Shunji Hoshino; Yousuke Takaoka; Jianxin Wang; Minoru Ueda

  iScience, Dec. 2023

  
• Subtype-selective agonists of plant hormone co-receptor COI1-JAZs identified from the stereoisomers of coronatine

  Takaoka Yousuke

  Communications Biology, 2023

  
• Genome Editing Reveals both the Crucial Role of OsCOI2 in Jasmonate Signaling, and the Functional Diversity of COI1 Homologs in Rice Functional Diversity of COI1 Homologs in Rice.

  Hideo Inagaki; Kengo Hayashi; Yousuke Takaoka; Hibiki Ito; Yuki Fukumoto; Ayaka Yajima-Nakagawa; Xi Chen; Miyuki Shimosato-Nonaka; Emmi Hassett; Kodai Hatakeyama; Yuko Hirakuri; Masanobu Ishitsuka; Emi Yumoto; Tomoko Sakazawa; Masashi Asahina; Kenichi Uchida; Kazunori Okada; Hisakazu Yamane; Minoru Ueda; Koji Miyamoto

  Plant & cell physiology, 06 Dec. 2022

  
• Coordinately regulated transcription factors EIN3/EIL1 and MYCs in ethylene and jasmonate signaling interact with the same domain of MED25.

  Ruiqi Liu; Hikaru Niimi; Minoru Ueda; Yousuke Takaoka

  Bioscience, biotechnology, and biochemistry, 25 Jul. 2022

  
• Protein-protein interactions between jasmonate-related master regulator MYC and transcriptional mediator MED25 depend on a short binding domain.

  Yousuke Takaoka; Kaho Suzuki; Akira Nozawa; Hirotaka Takahashi; Tatsuya Sawasaki; Minoru Ueda

  The Journal of biological chemistry, Jan. 2022

  
• Extended JAZ degron sequence for plant hormone binding in jasmonate co-receptor of tomato SlCOI1-SlJAZ.

  Rina Saito; Kengo Hayashi; Haruna Nomoto; Misuzu Nakayama; Yousuke Takaoka; Hiroaki Saito; Souhei Yamagami; Toshiya Muto; Minoru Ueda

  Scientific reports, 30 Jun. 2021

  
• Rational design of a stapled JAZ9 peptide inhibiting protein-protein interaction of a plant transcription factor

  Kaho Suzuki; Yousuke Takaoka; Minoru Ueda

  RSC CHEMICAL BIOLOGY, Apr. 2021, Peer-reviewed, Corresponding author

  
• Rational design of a stapled JAZ9 peptide inhibiting protein-protein interaction of a plant transcription factor (vol 2, pg 499, 2021)

  Takaoka Yousuke

  RSC Chemical Biology, 2021

  
• Erratum: Rational design of a stapled JAZ9 peptide inhibiting protein-protein interaction of a plant transcription factor (RSC Chemical Biology (2021) DOI: 10.1039/d0cb00204f)

  Suzuki, K.; Takaoka, Y.; Ueda, M.

  RSC Chemical Biology, 2021

  
• Deciphering OPDA Signaling Components in the Momilactone-Producing Moss Calohypnum plumiforme.

  Hideo Inagaki; Koji Miyamoto; Noriko Ando; Kohei Murakami; Koki Sugisawa; Shion Morita; Emi Yumoto; Miyu Teruya; Kenichi Uchida; Nobuki Kato; Takuya Kaji; Yousuke Takaoka; Yuko Hojo; Tomonori Shinya; Ivan Galis; Akira Nozawa; Tatsuya Sawasaki; Hideaki Nojiri; Minoru Ueda; Kazunori Okada

  Frontiers in plant science, 2021

  
• Ligand-receptor interactions in plant hormone signaling

  Jun Takeuchi; Kosuke Fukui; Yoshiya Seto; Yousuke Takaoka; Masanori Okamoto

  PLANT JOURNAL, Jan. 2021

  
• Hoechst-tagged Fluorescein Diacetate for the Fluorescence Imaging-based Assessment of Stomatal Dynamics in Arabidopsis thaliana

  Yousuke Takaoka; Saki Miyagawa; Akinobu Nakamura; Syusuke Egoshi; Shinya Tsukiji; Minoru Ueda

  SCIENTIFIC REPORTS, Mar. 2020

  
• A Fluorescence Anisotropy-Based Comprehensive Method for the In Vitro Screening of COI1–JAZs Agonists and Antagonists

  Yousuke Takaoka; Kengo Hayashi; Kaho Suzuki; Ika Nurul Azizah; Minoru Ueda

  Methods in Molecular Biology, 2020

  
• A comprehensive in vitro fluorescence anisotropy assay system for screening ligands of the jasmonate COI1-JAZ co-receptor in plants

  Yousuke Takaoka; Keina Nagumo; Ika Nurul Azizah; Saki Oura; Mana Iwahashi; Nobuki Kato; Minoru Ueda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 2019, Peer-reviewed

  
• A rationally designed JAZ subtype-selective agonist of jasmonate perception

  Yousuke Takaoka; Mana Iwahashi; Andrea Chini; Hiroaki Saito; Yasuhiro Ishimaru; Syusuke Egoshi; Nobuki Kato; Maho Tanaka; Khurram Bashir; Motoaki Seki; Roberto Solano; Minoru Ueda

  NATURE COMMUNICATIONS, Sep. 2018, Peer-reviewed

  
• Endogenous Membrane Receptor Labeling by Reactive Cytokines and Growth Factors to Chase Their Dynamics in Live Cells

  Yousuke Takaoka; Shohei Uchinomiya; Daichi Kobayashi; Masataka Endo; Takahiro Hayashi; Yoshiaki Fukuyama; Haruko Hayasaka; Masayuki Miyasaka; Takumi Ueda; Ichio Shimada; Itaru Hamachi

  CHEM, Jun. 2018, Peer-reviewed

  
• The alkyne-tag Raman imaging of coronatine, a plant pathogen virulence factor, in Commelina communis and its possible mode of action

  Minoru Ueda; Engo Hayashi; Syusuke Egoshi; Yasuhiro Ishimaru; Yousuke Takaoka; Hiroyuki Yamakoshi; Kosuke Dodo; Mikiko Sodeoka

  ORGANIC & BIOMOLECULAR CHEMISTRY, May 2018, Peer-reviewed

  
• Reactive group-embedded affinity labeling reagent for efficient intracellular protein labeling

  Yousuke Takaoka; Yuuki Nukadzuka; Minoru Ueda

  BIOORGANIC & MEDICINAL CHEMISTRY, Jun. 2017, Peer-reviewed

  
• Design and synthesis of a second-generation ligand-tethered calcium indicator for plant cell biology based on the fundamental analyses of the structure and physical property

  Yousuke Takaoka; Masaki Imai; Miyuki Shigenaga; Minoru Ueda

  TETRAHEDRON, May 2017, Peer-reviewed

  
• Noncanonical Function of a Small-Molecular Virulence Factor Coronatine against Plant Immunity: An In Vivo Raman Imaging Approach

  Minoru Ueda; Syusuke Egoshi; Kosuke Dodo; Yasuhiro Ishimaru; Hiroyuki Yamakoshi; Takeshi Nakano; Yousuke Takaoka; Shinya Tsukiji; Mikiko Sodeoka

  ACS CENTRAL SCIENCE, May 2017, Peer-reviewed

  
• A Novel Nuclear Receptor Ligand, Digoxigenin, is a Selective Antagonist of Liver-X-receptors

  Haruka Oishi; Yousuke Takaoka; Tomoko Nishimaki-Mogami; Hiroaki Saito; Minoru Ueda

  CHEMISTRY LETTERS, Mar. 2017, Peer-reviewed

  
• Protein ligand-tethered synthetic calcium indicator for localization control and spatiotemporal calcium imaging in plant cells (vol 26, pg 9, 2016)

  Yousuke Takaoka; Miyuki Shigenaga; Masaki Imai; Yuuki Nukadzuka; Yasuhiro Ishimaru; Kei Saito; Ryusuke Yokoyama; Kazuhiko Nishitani; Minoru Ueda

  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Jun. 2016

  
• Dual function of coronatine as a bacterial virulence factor against plants: possible COI1-JAZ-independent role

  Syusuke Egoshi; Yousuke Takaoka; Hiroaki Saito; Yuuki Nukadzuka; Kengo Hayashi; Yasuhiro Ishimaru; Hiroyuki Yamakoshi; Kosuke Dodo; Mikiko Sodeoka; Minoru Ueda

  RSC ADVANCES, 2016, Peer-reviewed

  
• Protein ligand-tethered synthetic calcium indicator for localization control and spatiotemporal calcium imaging in plant cells

  Takaoka Y; Shigenaga M; Imai M; Nukadzuka Y; Ishimaru Y; Saito K; Yokoyama R; Nishitani K; Ueda M

  Bioorganic and Medicinal Chemistry Letters, 2016, Peer-reviewed

  
• Biomembrane-embedded Catalysts for Membrane-associated Protein Labeling on Red Blood Cells

  Yuki Yasueda; Tomonori Tamura; Keiko Kuwara; Yousuke Takaoka; Itaru Hamachi

  CHEMISTRY LETTERS, Dec. 2015, Peer-reviewed

  
• Analysis of Cell-Surface Receptor Dynamics through Covalent Labeling by Catalyst-Tethered Antibody

  Takahiro Hayashi; Yuki Yasueda; Tomonori Tamura; Yousuke Takaoka; Itaru Hamachi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Apr. 2015

  
• Extended Affinity-guided DMAP Chemistry with a Finely Tuned Acyl Donor for Intracellular FKBP12 Labeling

  Zhining Song; Yousuke Takaoka; Yoshiyuki Kioi; Kazuhiro Komatsu; Tomonori Tamura; Takayuki Miki; Itaru Hamachi

  CHEMISTRY LETTERS, Mar. 2015, Peer-reviewed

  
• Ligand-directed dibromophenyl benzoate chemistry for rapid and selective acylation of intracellular natural proteins

  Yousuke Takaoka; Yuki Nishikawa; Yuki Hashimoto; Kenta Sasaki; Itaru Hamachi

  CHEMICAL SCIENCE, 2015, Peer-reviewed

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• Intracellular Protein-Responsive Supramolecules: Protein Sensing and In-Cell Construction of Inhibitor Assay System

  Tatsuyuki Yoshii; Keigo Mizusawa; Yousuke Takaoka; Itaru Hamachi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Nov. 2014, Peer-reviewed

  
• Acidic-pH-Activatable Fluorescence Probes for Visualizing Exocytosis Dynamics

  Daisuke Asanuma; Yousuke Takaoka; Shigeyuki Namiki; Kenji Takikawa; Mako Kamiya; Tetsuo Nagano; Yasuteru Urano; Kenzo Hirose

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Jun. 2014, Peer-reviewed

  
• Live cell off-target identification of lapatinib using ligand-directed tosyl chemistry

  Kei Yamaura; Keiko Kuwata; Tomonori Tamura; Yoshiyuki Kioi; Yousuke Takaoka; Shigeki Kiyonaka; Itaru Hamachi

  CHEMICAL COMMUNICATIONS, 2014, Peer-reviewed

  
• Heme-Transfer Mechanism of Structurally Similar Isd NEAT Domains of Staphylococcus Aureus Exhibiting Different Affinities for Heme

  Yoshitaka Moriwaki; Tohru Terada; Jose M. M. Caaveiro; Yousuke Takaoka; Itaru Hamachi; Kouhei Tsumoto; Kentaro Shimizu

  BIOPHYSICAL JOURNAL, Jan. 2014, Peer-reviewed

  
• Heme Binding Mechanism of Structurally Similar Iron-Regulated Surface Determinant Near Transporter Domains of Staphylococcus aureus Exhibiting Different Affinities for Heme

  Yoshitaka Moriwaki; Tohru Terada; Jose M. M. Caaveiro; Yousuke Takaoka; Itaru Hamachi; Kouhei Tsumoto; Kentaro Shimizu

  BIOCHEMISTRY, Dec. 2013, Peer-reviewed

  
• Disassembly-driven Turn-on Sensing of Enzyme Activity by Substrate-based Fluorescent Nanoprobe

  Yousuke Takaoka; Yoshiaki Fukuyama; Kazuya Matsuo; Itaru Hamachi

  CHEMISTRY LETTERS, Nov. 2013, Peer-reviewed

  
• Specific Detection and Imaging of Enzyme Activity by Signal-Amplifiable Self-Assembling F-19 MRI Probes

  Kazuya Matsuo; Rui Kamada; Keigo Mizusawa; Hirohiko Imai; Yuki Takayama; Michiko Narazaki; Tetsuya Matsuda; Yousuke Takaoka; Itaru Hamachi

  CHEMISTRY-A EUROPEAN JOURNAL, Sep. 2013

  
• Semisynthetic Lectin-4-Dimethylaminopyridine Conjugates for Labeling and Profiling Glycoproteins on Live Cell Surfaces

  Takahiro Hayashi; Yedi Sun; Tomonori Tamura; Keiko Kuwata; Zhining Song; Yousuke Takaoka; Itaru Hamachi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2013, Peer-reviewed

  
• One-step construction of caged carbonic anhydrase I using a ligand-directed acyl imidazole-based protein labeling method

  Kazuya Matsuo; Yoshiyuki Kioi; Ryosuke Yasui; Yousuke Takaoka; Takayuki Miki; Sho-hei Fujishima; Itaru Hamachi

  CHEMICAL SCIENCE, 2013, Peer-reviewed

  
• Protein Organic Chemistry and Applications for Labeling and Engineering in Live-Cell Systems

  Yousuke Takaoka; Akio Ojida; Itaru Hamachi

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2013, Peer-reviewed

  
• Quantitative comparison of protein dynamics in live cells and in vitro by in-cell F-19-NMR

  Yousuke Takaoka; Yoshiyuki Kioi; Akira Morito; Junji Otani; Kyohei Arita; Eishi Ashihara; Mariko Ariyoshi; Hidehito Tochio; Masahiro Shirakawa; Itaru Hamachi

  CHEMICAL COMMUNICATIONS, 2013, Peer-reviewed

  
• Specific Cell Surface Protein Imaging by Extended Self-Assembling Fluorescent Turn-on Nanoprobes

  Keigo Mizusawa; Yousuke Takaoka; Itaru Hamachi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2012, Peer-reviewed

  
• Systematic Study of Protein Detection Mechanism of Self-Assembling F-19 NMR/MRI Nanoprobes toward Rational Design and Improved Sensitivity

  Yousuke Takaoka; Keishi Kiminami; Keigo Mizusawa; Kazuya Matsuo; Michiko Narazaki; Tetsuya Matsuda; Itaru Hamachi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2011, Peer-reviewed

  
• Construction of a F-19-lectin biosensor for glycoprotein imaging by using affinity-guided DMAP chemistry

  Yedi Sun; Yousuke Takaoka; Shinya Tsukiji; Michiko Narazaki; Tetsuya Matsuda; Itaru Hamachi

  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Aug. 2011, Peer-reviewed

  
• Mechanisms of chemical protein F-19-labeling and NMR-based biosensor construction in vitro and in cells using self-assembling ligand-directed tosylate compounds

  Yousuke Takaoka; Yedi Sun; Shinya Tsukiji; Itaru Hamachi

  CHEMICAL SCIENCE, 2011, Peer-reviewed

  
• Disassembly-Driven Turn-On Fluorescent Nanoprobes for Selective Protein Detection

  Keigo Mizusawa; Yoshiyuki Ishida; Yousuke Takaoka; Masayoshi Miyagawa; Shinya Tsukiji; Itaru Hamachi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jun. 2010

  
• Self-assembling nanoprobes that display off/on F-19 nuclear magnetic resonance signals for protein detection and imaging

  Yousuke Takaoka; Takashi Sakamoto; Shinya Tsukiji; Michiko Narazaki; Tetsuya Matsuda; Hidehito Tochio; Masahiro Shirakawa; Itaru Hamachi

  NATURE CHEMISTRY, Oct. 2009, Peer-reviewed

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• Quenched Ligand-Directed Tosylate Reagents for One-Step Construction of Turn-On Fluorescent Biosensors

  Shinya Tsukiji; Hangxiang Wang; Masayoshi Miyagawa; Tomonori Tamura; Yousuke Takaoka; Itaru Hamachi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jul. 2009, Peer-reviewed

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• Ligand-directed tosyl chemistry for protein labeling in vivo

  Shinya Tsukiji; Masayoshi Miyagawa; Yousuke Takaoka; Tomonori Tamura; Itaru Hamachi

  NATURE CHEMICAL BIOLOGY, May 2009, Peer-reviewed

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• Engineering of endogenous protein by ligand-directed tosyl chemistry: Construction of a 19F NMR biosensor in live cells

  Yousuke Takaoka; Shinya Tsukiji; Itaru Hamachi

  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Mar. 2009

  
• Affinity-labeling-based introduction of a reactive handle for natural protein modification

  Haruto Wakabayashi; Masayoshi Miyagawa; Yoichiro Koshi; Yousuke Takaoka; Shinya Tsukiji; Itaru Hamachi

  CHEMISTRY-AN ASIAN JOURNAL, 2008, Peer-reviewed

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• One-pot and sequential organic chemistry on an enzyme surface to tether a fluorescent probe at the proximity of the active site with restoring enzyme activity.

  Yousuke Takaoka; Hiroshi Tsutsumi; Noriyuki Kasagi; Eiji Nakata; Itaru Hamachi

  Journal of the American Chemical Society, 15 Mar. 2006

  

Misc.

• イネのジャスモン酸受容体OsCOI2の下流シグナル伝達の解明

  稲垣秀生; 湯本絵美; 高岡洋輔; 岡田憲典; 上田実; 上田実; 宮本皓司

  日本植物学会大会研究発表記録(CD-ROM), 2023

  
• Elucidation of the downstream signal of OsCOI2 that play a crucial role in rice JA response

  稲垣秀生; 池田百伽; 湯本絵美; 林謙吾; 高岡洋輔; 上田実; 宮本皓司; 宮本皓司

  植物の生長調節, 2022

  
• Development of receptor subtype selective ligands via focused library screening composed of stereoisomers of coronatine

  林謙吾; 加藤信樹; 野本春菜; 中山美涼; 加治拓哉; 渡部楽; 齊藤里菜; 高岡洋輔; 宮本皓司; 稲垣秀生; 岡田憲典; 上田実

  日本化学会春季年会講演予稿集(Web), 2021

  
• Research on functional difference of jasmonate receptors in rice

  稲垣秀生; 湯本絵美; 朝比奈雅志; 内田健一; 朝比奈雅志; 内田健一; 林謙吾; 加治拓哉; 高岡洋輔; 上田実; 岡田憲典; 山根久和; 山根久和; 宮本皓司

  植物の生長調節, 2020

  
• Development of receptor subtype selective ligands via focused library screening composed of stereoisomers of coronatine

  林謙吾; 加藤信樹; 渡部楽; 高岡洋輔; 野本春菜; 中山美涼; 宮川咲季; 宮本皓司; 稲垣秀生; 岡田憲典; 加治拓哉; 上田実

  天然有機化合物討論会講演要旨集(Web), 2020

  
• 植物ホルモン・ジャスモン酸の多様な活性を制御するケミカルツールの合理的設計 植物の生長と防御を操作する化合物の創製

  高岡洋輔; 高岡洋輔; 上田実; 上田実

  化学と生物, 2020

  
• 植物細胞への機能性小分子の送達と局在制御

  高岡洋輔; 高岡洋輔

  アグリバイオ, 2019

  
• ジャスモン酸受容体のサブタイプ選択性を制御する化合物の創製研究

  高岡洋輔

  植物の生長調節, 2019

  
• 有機化学者が計算化学者に助けてもらってリガンド-受容体間ドッキングシミュレーションによる分子設計に成功するまで

  上田実; 高岡洋輔; 齋藤大明

  アンサンブル, 2019

  
• Enantiodifferential Approach for the Target Protein Detection of the Jasmonate Glucoside That Controls the Leaf Closure of Samanea saman

  Takaoka Yousuke

  Methods in Molecular Biology, 01 Jan. 2018

  
• 支部発話題欄 2 植物細胞内分子イメージングへの挑戦

  高岡洋輔; 高岡洋輔

  化学と工業, 2017

  
• 内在性サイトカイン受容体のケミカルラベルによる生細胞イメージング

  高岡洋輔; 高岡洋輔; 高岡洋輔; 高岡洋輔; 高岡洋輔; 内之宮祥平; 小林大地; 林隆弘; 福山嘉明; 早坂晴子; 宮坂昌之; 上田卓見; 嶋田一男; 浜地格

  日本生化学会大会(Web), Sep. 2016

  
• ジャスモン酸共受容体サブタイブ選択的アゴニストの合理的設計とin vivo機能評価

  高岡洋輔; 岩橋万奈; 斎藤大明; 江越脩祐; 加藤信樹; 石丸泰寛; 上田実

  植物の生長調節, 2016

  
• 植物ホルモン受容体を標的としたサブタイプ選択的PPI誘起リガンドの開発

  岩橋万奈; 江越脩祐; 齋藤大明; 石丸泰寛; 高岡洋輔; 上田実

  天然有機化合物討論会講演要旨集(Web), 2016

  
• S09 Development of subtype selective agonist of Jasmonate Co-receptor

  Takaoka Yousuke; Iwashita Toshiki; Iwahashi Mana; Hayashi Kengo; Suzuki Takeshi; Ishimaru Yasuhiro; Egoshi Shusuke; Ueda Minoru

  植物化学調節学会研究発表記録集, 01 Oct. 2015

  
• 植物毒素コロナチンの誘導体化による植物ホルモン受容体サブタイプ選択的アゴニスト開発と未知標的探索

  高岡洋輔; 岩下利基; 岩橋万奈; 鈴木健史; 林謙吾; 石丸泰寛; 江越脩祐; 上田実

  天然有機化合物討論会講演要旨集(Web), 2015

  
• 合成ナノプローブによる細胞内タンパク質可逆センシング

  高岡洋輔

  化学と工業, 2015

  
• In cell NMRに向けた化学-生物学的アプローチ

  高岡洋輔; 浜地格

  生体の科学, 2014

  
• Detection and Imaging of Protein Activity with Dynamic Self-Assembling Turn-on Nanoprobes

  TAKAOKA Yousuke; HAMACHI Itaru

  高分子, 01 Jun. 2013

  
• Acidic-pH activatable fluorescence probes for monitoring exocytosis dynamics

  Daisuke Asanuma; Yousuke Takaoka; Shigeyuki Namiki; Kenji Takikawa; Mako Kamiya; Tetsuo Nagano; Yasuteru Urano; Kenzo Hirose

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2013

  
• 分子イメージングの新ステージ 細胞有機化学による斬新な化学プローブ分子の誕生

  高岡洋輔; 築地真也; 浜地格; 築地真也; 浜地格

  化学, 2009

  
• 生命化学とバイオ計測 タンパク質の特異的ラベリングと検出

  高岡洋輔; 浜地格

  未来材料, 2007

  
• Synthesis and guest-binding study of polytopic multi(cyclophane) hosts

  HAYASHIDA Osamu; HAYASHIDA Osamu; TAKAOKA Yousuke; HAMACHI Itaru

  Tetrahedron Letters, 2005

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Presentations

• Self-assembling turn-on nanoprobe for endogenous protein sensing

  China/Japan Young Chemists Forum, 04 Aug. 2014

  

Awards

• 26 Mar. 2015

  日本化学会第95回春季年会若い世代の特別講演会顕彰
• 19 May 2009

  第4回日本ケミカルバイオロジー学会　優秀ポスター賞
• 09 Oct. 2021

  日本農芸化学会東北支部奨励賞
• 16 Nov. 2019

  植物化学調節学会奨励賞
• 26 Mar. 2014

  日本化学会第94回春季年会優秀講演賞（学術)
• 12 Sep. 2009

  第20回生体関連化学若手の会サマースクール優秀ポスター賞（日本化学会）
• 05 Sep. 2019

  第13回バイオ関連化学シンポジウム部会講演賞（日本化学会生体機能関連化学部会）
• 21 Mar. 2012

  日本化学会第92回春季年会優秀講演賞（学術)
• 13 Dec. 2012

  第29回井上研究奨励賞（（公財）井上科学振興財団）

External funds: Kakenhi

• 天然変性タンパク質の植物個体中での立体構造固定法の開発

  Grant-in-Aid for Challenging Research (Pioneering)

  Medium-sized Section 37:Biomolecular chemistry and related fields

  Tohoku University

  高岡 洋輔

  From 30 Jun. 2023, To 31 Mar. 2026, Granted

  天然変性;生体直交性反応;植物ホルモン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K17371/
• Development of random loop-stapling peptide for ubiquitin code analyses

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Complex systems

  Tohoku University

  高岡 洋輔

  From 01 Apr. 2019, To 31 Mar. 2021, Project Closed

  ユビキチンリガーゼ;ペプチド;ケミカルバイオロジー;植物ホルモン

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-19H05283/
• Regulation of plant hormone receptor using stereochemical isomers of a natural product

  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

  Medium-sized Section 37:Biomolecular chemistry and related fields

  Tohoku University

  Minoru UEDA

  From 07 Feb. 2019, To 31 Mar. 2022, Project Closed

  植物ホルモン;ジャスモン酸;受容体;遺伝的冗長性;コロナチン;立体異性体;化学プローブ;標的選択性;活性チューニング;二次代謝

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18KK0162/
• Studies on chemical communication on host-selective toxins

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Science and Engineering

  Tohoku University

  Minoru Ueda

  From 30 Jun. 2017, To 31 Mar. 2022, Project Closed

  植物ホルモン;ジャスモン酸;受容体;遺伝的冗長性;立体異性体;アゴニスト;宿主選択的毒素;AK-トキシン;コロナチン;COI1-JAZ共受容体;宿主特異的毒素;化学プローブ;標的選択性;天然物化学;植物毒素;ケミカルバイオロジー;生物活性天然物

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-17H06407/
• Chemical biology of natural products involved in plant-microbe interaction

  Grant-in-Aid for Scientific Research (A)

  Tohoku University

  Minoru Ueda

  From 01 Apr. 2017, To 31 Mar. 2020, Project Closed

  植物ホルモン;ジャスモン酸;受容体;遺伝的冗長性;宿主選択的毒素;AK-トキシン;コロナチン;立体異性体;標的選択性;生物間相互作用;天然物;宿主非選択的毒素;天然物化学;ケミカルバイオロジー;化学生態学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H00885/
• Development of novel methods for efficient derivery system of functional molecular probes in plant cells

  Grant-in-Aid for Challenging Exploratory Research

  Tohoku University

  Yousuke Takaoka

  From 01 Apr. 2016, To 31 Mar. 2018, Project Closed

  ケミカルバイオロジー;ライブセルイメージング;細胞内分子送達;蛍光イメージング;植物生理学;タンパク質;植物;細胞・組織;バイオイメージング

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K13093/
• 改良型リガンド指向性触媒反応による細胞内標的タンパク質の効率的ラベル化技術の構築

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Science and Engineering

  Tohoku University

  高岡 洋輔

  From 01 Apr. 2014, To 31 Mar. 2016, Project Closed

  蛋白質;細胞・組織;生体分子;生理活性;プロテオーム

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-26102729/
• Real time and reversible imaging of cytokine receptors on living cells based on supramolecular approaches

  Grant-in-Aid for Young Scientists (A)

  Tohoku University;Kyoto University

  Yousuke Takaoka

  From 01 Apr. 2013, To 31 Mar. 2017, Project Closed

  蛋白質間相互作用;ケミカルバイオロジー;超分子;蛋白質化学修飾;蛋白質;受容体;イメージング;サイトカイン;バイオテクノロジー;細胞・組織

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25708026/
• 多点反応性ラベル化剤による天然物リガンド標的タンパク質化学修飾法の開発

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Science and Engineering

  Kyoto University

  高岡 洋輔

  From 01 Apr. 2012, To 31 Mar. 2014, Project Closed

  蛋白質;細胞・組織;生体分子;生理活性;プロテオーム;ケミカルバイオロジー;タンパク質工学;タンパク質ラベリング

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-24102516/
• Development of Chemical Protein Labeling method for Spatiotemporal Modulation of Endogenous Protein Activity in Cells

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  Yousuke TAKAOKA

  From 01 Apr. 2011, To 31 Mar. 2013, Project Closed

  タンパク質;ケミカルバイオロジー;化学修飾;酵素;リガンド;自己集合

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23750188/
• 遺伝子レベルでの天然変性領域リデザインによる植物ホルモン間クロストークの人工制御

  Grant-in-Aid for Scientific Research (B)

  Basic Section 37030:Chemical biology-related

  Tohoku University

  高岡 洋輔

  From 01 Apr. 2025, To 31 Mar. 2028, Adopted

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25K01908/
• Analyses of the relationship between degradation and function of plant hormone receptors by using chemical tools

  Grant-in-Aid for Scientific Research (B)

  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related

  Tohoku University

  高岡 洋輔

  From 01 Apr. 2022, To 31 Mar. 2025, Granted

  ケミカルバイオロジー;タンパク質工学;タンパク質分解;植物ホルモン;タンパク質間相互作用

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K23473/
• Ancestral plant hormone and molecular evolution of plant hormone signaling

  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

  Medium-sized Section 37:Biomolecular chemistry and related fields

  Tohoku University

  上田 実

  From 07 Oct. 2022, To 31 Mar. 2025, Granted

  ジャスモン酸;始原植物ホルモン;ゼニゴケ;受容体;delta4-dn-OPDA

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22KK0076/
• Development of selective chemical tool box useful for analyses of the ubiquitin ligase substrates

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Complex systems

  Tohoku University

  高岡 洋輔

  From 01 Apr. 2021, To 31 Mar. 2023, Project Closed

  ケミカルバイオロジー;ユビキチン;植物ホルモン

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-21H00270/
• Chemical biology of natural products on plant hormones

  Grant-in-Aid for Scientific Research (A)

  Medium-sized Section 37:Biomolecular chemistry and related fields

  Tohoku University

  Minoru Ueda

  From 01 Apr. 2020, To 31 Mar. 2023, Project Closed

  植物ホルモン;ジャスモン酸;受容体;遺伝的冗長性;コロナチン;立体異性体;選択的アゴニスト;標的選択性;ジャスモン酸イソロイシン;COI1-JAZ共受容体;化学プローブ;二次代謝;活性チューニング

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H00402/
• Regulation of protein-protein interaction of phytohormone co-receptor with molecular-targeted reactive drug

  Grant-in-Aid for Scientific Research (B)

  Basic Section 37030:Chemical biology-related

  Tohoku University

  Yousuke Takaoka

  From 01 Apr. 2018, To 31 Mar. 2022, Project Closed

  植物ホルモン;タンパク質間相互作用;ケミカルバイオロジー

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H02101/

Education

Teaching subject(s)

• From 01 Apr. 2025, To 31 Mar. 2026

  Chemistry of Biological Activity

  CA19, Spring, Graduate School of Agriculture, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  Applied Life Sciences I

  CA01, Spring, Graduate School of Agriculture, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  Biofunction Chemistry Seminar

  CF09, Spring, Graduate School of Agriculture, 1.5
• From 01 Apr. 2025, To 31 Mar. 2026

  Biofunction Chemistry Seminar

  CF09, Fall, Graduate School of Agriculture, 1.5
• From 01 Apr. 2025, To 31 Mar. 2026

  Experimental Course of Biofunction Chemistry

  CG09, Spring, Graduate School of Agriculture, 3
• From 01 Apr. 2025, To 31 Mar. 2026

  Experimental Course of Biofunction Chemistry

  CG09, Fall, Graduate School of Agriculture, 3
• From 01 Apr. 2025, To 31 Mar. 2026

  Bioorganic Chemistry II

  5630, Fall, Faculty of Agriculture, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Bioorganic Chemistry I

  5627, Spring, Faculty of Agriculture, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Outline of Applied Life Sciences

  5801, Spring, Faculty of Agriculture, 2

Administration

Faculty management (title, position)

• From 01 Apr. 2025, To 30 Jun. 2027

  比較農業論講座運営協議員会　協議員