Basic Information

Faculty

• 医学部

Academic Degree

• 博士（医学）(京都大学)

Language of Instruction

• English
• Japanese

ID,URL

• J-Global ID

  200901010037208489

researchmap URL

• https://researchmap.jp/read0138462

Research

Research Topics, Overview of the research

• Research Topics

  呼吸生理学、画像解析、形態学

Research Areas

• Life sciences, Respiratory medicine

Papers

• 新たな肺腺癌脳転移モデルを用いた抗PD-1/CTLA-4抗体併用療法の有効性と作用機序の検討(Novel Model of Lung Adenocarcinoma Brain Metastasis Reveals Efficacy of Anti-PD-1/CTLA-4 Combination Therapy)

  細谷 和貴; 小笹 裕晃; 辻 貴宏; 島 佑介; 住永 圭一郎; 橋本 健太郎; 吉田 寛; 味水 瞳; 船造 智子; 吉田 博徳; 野溝 岳; 和氣 弘明; 平井 豊博; 辻 貴宏

  日本癌学会総会記事, Sep. 2024

  
• Antigravity muscle density on computed tomography and health-related independence in normal weight patients with chronic obstructive pulmonary disease.

  Satoru Terada; Naoya Tanabe; Tomoki Maetani; Yusuke Shiraishi; Kunihiko Terada; Hiroshi Shima; Tsuyoshi Oguma; Ryo Sakamoto; Megumi Kanasaki; Izuru Masuda; Atsuyasu Sato; Susumu Sato; Toyohiro Hirai

  Respiratory research, 13 Apr. 2025

  
• 睡眠呼吸障害、肥満、生活習慣病の関連と性差 ながはまスタディ

  松本 健; 村瀬 公彦; 田原 康玄; 若村 智子; 中山 健夫; 平井 豊博; 松田 文彦; 陳 和夫

  日本睡眠学会定期学術集会プログラム・抄録集, Jul. 2024

  
• 一般人口大規模コホートにおける睡眠呼吸障害と血中ヘモグロビン濃度の関係 ながはまコホート研究

  村瀬 公彦; 松本 健; 田原 康玄; 高橋 順美; 若村 智子; 米浪 直子; 瀬藤 和也; 川口 喬久; 佐藤 晋; 平井 豊博; 松田 文彦; 陳 和夫

  日本睡眠学会定期学術集会プログラム・抄録集, Jul. 2024

  
• Stationary Oxygen Concentrator with Built-in Respiratory Rate Monitor: Clinical Validation of Its Efficacy in Patients with Interstitial Lung Disease and Chronic Obstructive Pulmonary Disease.

  Satoshi Hamada; Tomohiro Handa; Kimihiko Murase; Naoya Tanabe; Yoshinari Nakatsuka; Kohei Ikezoe; Hironobu Sunadome; Susumu Sato; Atsuyasu Sato; Toyohiro Hirai

  Internal medicine (Tokyo, Japan), 08 Mar. 2025

  
• Pneumatosis Intestinalis Induced by Nintedanib.

  Satoshi Hamada; Naoya Tanabe; Toyohiro Hirai

  Internal medicine (Tokyo, Japan), 18 Feb. 2025

  
• Spirometry estimation of central airway dysanapsis on computed tomography in healthy subjects without active lung diseases.

  Takafumi Shimada; Naoya Tanabe; Fumi Mochizuki; Hiroaki Iijima; Kaoruko Shimizu; Shotaro Chubachi; Kazuya Tanimura; Susumu Sato; Toyohiro Hirai; Nobuyuki Hizawa

  Journal of applied physiology (Bethesda, Md. : 1985), 01 Feb. 2025

  
• Prognostic value of a composite physiologic index developed by adding bronchial and hyperlucent volumes quantified via artificial intelligence technology.

  Michihiro Uyama; Tomohiro Handa; Ryuji Uozumi; Seishu Hashimoto; Yoshio Taguchi; Kohei Ikezoe; Kiminobu Tanizawa; Naoya Tanabe; Tsuyoshi Oguma; Atsushi Matsunashi; Takafumi Niwamoto; Hiroshi Shima; Ryobu Mori; Tomoki Maetani; Yusuke Shiraishi; Tomomi W Nobashi; Ryo Sakamoto; Takeshi Kubo; Akihiko Yoshizawa; Kazuhiro Terada; Yuji Nakamoto; Toyohiro Hirai

  Respiratory research, 24 Dec. 2024

  
• Correlation of sleep-disordered breathing with anemia and microcytosis in premenopausal women: the Nagahama study.

  Kimihiko Murase; Takeshi Matsumoto; Yasuharu Tabara; Miho Egawa; Takuma Minami; Osamu Kanai; Naomi Takahashi; Satoshi Hamada; Hironobu Sunadome; Jumpei Togawa; Takuma Ohsuga; Tomoko Wakamura; Naoko Komenami; Kazuya Setoh; Takahisa Kawaguchi; Takeo Nakayama; Susumu Sato; Masaki Mandai; Toyohiro Hirai; Fumihiko Matsuda; Kazuo Chin

  Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 20 Mar. 2025

  
• ALK肺がんにおける分子標的薬に対するTEAD阻害薬の併用効果のバイオマーカー探索(Biomarkers for Efficacy of TEAD Inhibitor Combination with Molecularly targeted drugs in ALK Lung Cancer)

  橋本 健太郎; 小笹 裕晃; 島 佑介; 住永 圭一郎; 吉田 寛; 細谷 和貴; 船造 智子; 味水 瞳; 吉田 博徳; 野溝 岳; Tang Tracy T.; 平井 豊博; 小笹 裕晃

  日本癌学会総会記事, Sep. 2024

  
• 肺癌肝転移成立の機序からの新規治療因子の探索(Exploration of novel therapeutic factors in the mechanism of establishment of liver metastases in lung cancer)

  吉田 寛; 小笹 裕晃; 味水 瞳; 細谷 和貴; 島 佑介; 住永 圭一郎; 橋本 健太郎; 山本 智子; 野溝 岳; 吉田 博徳; 平井 豊博; 小笹 裕晃

  日本癌学会総会記事, Sep. 2024

  
• 新たな肺腺癌脳転移モデルを用いた抗PD-1/CTLA-4抗体併用療法の有効性と作用機序の検討(Novel Model of Lung Adenocarcinoma Brain Metastasis Reveals Efficacy of Anti-PD-1/CTLA-4 Combination Therapy)

  細谷 和貴; 小笹 裕晃; 辻 貴宏; 島 佑介; 住永 圭一郎; 橋本 健太郎; 吉田 寛; 味水 瞳; 船造 智子; 吉田 博徳; 野溝 岳; 和氣 弘明; 平井 豊博; 辻 貴宏

  日本癌学会総会記事, Sep. 2024

  
• ニボルマブ投与中の非小細胞肺癌患者に発症した感染症に関する検討

  藤田 浩平; 金井 修; 平井 豊博; 金 永学; 三尾 直士

  日本化学療法学会雑誌, Apr. 2018

  
• 非結核性抗酸菌症の今日的問題 再発・難治性肺Mycobacterium avium complex(MAC)症患者に対するsitafloxacin(STFX)の有用性の検討

  藤田 浩平; 藤田 昌樹; 伊藤 穣; 平井 豊博; 三尾 直士; 渡辺 憲太朗; 三嶋 理晃

  日本呼吸器学会誌, Mar. 2016

  
• Safety and efficacy of pemetrexed for patients with non-small cell lung cancer in the setting of renal impairment: a retrospective study

  Yusuke Shima; Hironori Yoshida; Keiichiro Suminaga; Hiroshi Yoshida; Kentaro Hashimoto; Tatsuya Ogimoto; Kazutaka Hosoya; Hitomi Ajimizu; Tomoko Funazo; Takashi Nomizo; Hiroaki Ozasa; Toyohiro Hirai

  BMC Cancer, 04 Mar. 2025

  
• Usefulness of pro-gastrin-releasing peptide as a predictor of the incidence of brain metastasis and effect of prophylactic cranial irradiation in patients with limited-stage small-cell lung cancer

  Ueki, Kazuhito; Matsuo, Yukinori; Kishi, Noriko; Yoneyama, Masahiro; Yoshida, Hironori; Sakamori, Yuichi; Ozasa, Hiroaki; Hirai, Toyohiro; Mizowaki, Takashi

  Journal of Radiation Research, Jul. 2022

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• Sputum short-chain fatty acids, microbiome, inflammation, and mucus plugging in obstructive airway disease.

  Naoya Tanabe; Hisako Matsumoto; Chie Morimoto; Toyohiro Hirai

  The Journal of allergy and clinical immunology, 04 Feb. 2025

  
• Descriptive Epidemiology and Prognostic Significance of Diaphragm Thickness in the General Population: The Nagahama Study.

  Yasuharu Tabara; Takeshi Matsumoto; Kimihiko Murase; Takahisa Kawaguchi; Kazuya Setoh; Tomoko Wakamura; Toyohiro Hirai; Kazuo Chin; Fumihiko Matsuda

  Journal of cachexia, sarcopenia and muscle, Feb. 2025

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• Intraindividual correlations between nocturnal urination frequency and sleep blood pressure: the Nagahama Study.

  Yasuharu Tabara; Takeshi Matsumoto; Kimihiko Murase; Takahisa Kawaguchi; Kazuya Setoh; Tomoko Wakamura; Toyohiro Hirai; Kazuo Chin; Fumihiko Matsuda

  Hypertension research : official journal of the Japanese Society of Hypertension, 09 Jan. 2025

  
• Trajectory of the arterial-alveolar oxygen gradient in COPD for a decade.

  Kazuma Nagata; Susumu Sato; Kiyoshi Uemasu; Naoya Tanabe; Atsuyasu Sato; Shigeo Muro; Toyohiro Hirai

  PloS one, 2025

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• Associations Among Sleep Apnea, Objective or Subjective Sleep Duration, and Recurrence of Atrial Fibrillation in Patients Who Undergo Radiofrequency Catheter Ablation for Persistent Atrial Fibrillation ― A Prospective Observational Study ―

  Takuma Minami; Takashi Yoshizawa; Kimihiko Murase; Akihiko Komasa; Takanori Aizawa; Shintaro Yamagami; Munekazu Tanaka; Satoshi Shizuta; Susumu Sato; Koh Ono; Toyohiro Hirai; Takeshi Kimura; Kazuo Chin

  Circulation Journal, 12 Nov. 2024

  
• Sex differences among sleep disordered breathing, obesity, and metabolic comorbidities; the Nagahama study.

  Takeshi Matsumoto; Kimihiko Murase; Yasuharu Tabara; Takuma Minami; Osamu Kanai; Hironobu Sunadome; Naomi Takahashi; Satoshi Hamada; Kiminobu Tanizawa; Tomoko Wakamura; Naoko Komenami; Kazuya Setoh; Takahisa Kawaguchi; Satoshi Morita; Yoshimitsu Takahashi; Takeo Nakayama; Susumu Sato; Toyohiro Hirai; Fumihiko Matsuda; Kazuo Chin

  Respiratory investigation, 03 Dec. 2024

  
• Computed tomography morphological assessments of central airways in interstitial lung abnormalities and idiopathic pulmonary fibrosis.

  Tomoki Maetani; Naoya Tanabe; Kiminobu Tanizawa; Ryo Sakamoto; Yusuke Shiraishi; Yusuke Hayashi; Michihiro Uyama; Atsushi Matsunashi; Susumu Sato; Katsuhiro Suzuki; Izuru Masuda; Motonari Fukui; Shizuo Kaji; Tomohiro Handa; Toyohiro Hirai

  Respiratory research, 10 Nov. 2024

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• A protocol for a Japanese prospective cohort evaluating the features of patients with uncontrolled asthma achieving clinical remission: J-CIRCLE.

  Naoya Tanabe; Yu Hara; Kaoruko Shimizu; Satoshi Marumo; Jun Miyata; Kyohei Morita; Tetsuya Watanabe; Keiji Oishi; Masafumi Yamaguchi; Kazuhisa Asai; Yasutaka Nakano; Tsunahiko Hirano; Kazuto Matsunaga; Toshiyuki Koya; Hisako Matsumoto; Koichi Fukunaga; Satoshi Konno; Takeshi Kaneko; Toyohiro Hirai

  Respiratory investigation, 04 Nov. 2024

  
• Longitudinal assessment of interstitial lung abnormalities on CT in patients with COPD using artificial intelligence-based segmentation: a prospective observational study.

  Yusuke Shiraishi; Naoya Tanabe; Ryo Sakamoto; Tomoki Maetani; Shizuo Kaji; Hiroshi Shima; Satoru Terada; Kunihiko Terada; Kohei Ikezoe; Kiminobu Tanizawa; Tsuyoshi Oguma; Tomohiro Handa; Susumu Sato; Shigeo Muro; Toyohiro Hirai

  BMC pulmonary medicine, 23 Apr. 2024

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• 慢性閉塞性肺疾患(COPD)とフレイル・体組成・栄養摂取量の関連

  前谷 知毅; 田辺 直也; 白石 祐介; 寺田 悟; 張 怡; 大島 洋平; 吉岡 佑二; 濱田 涼太; 佐藤 晋; 池田 香織; 佐藤 篤靖; 平井 豊博

  日本呼吸器学会誌, Mar. 2024

  
• COPD患者におけるLife Space Assessmentで評価した活動水準とフレイル,サルコペニアおよび3軸加速度計を用いた身体活動量の関連

  白石 祐介; 田辺 直也; 前谷 知毅; 張 怡; 大島 洋平; 吉岡 佑二; 濱田 涼太; 佐藤 篤靖; 佐藤 晋; 平井 豊博

  日本呼吸ケア・リハビリテーション学会誌, Nov. 2023

  
• 喘息 疫学・データ解析 生物学的製剤投与下の重症喘息におけるasthma control testと臨床指標の性別差異

  林 優介; 田辺 直也; 丸毛 聡; 森田 恭平; 高橋 祥太; 石川 遼一; 吉村 千恵; 塚本 信哉; 船内 敦司; 福井 基成; 室橋 光太; 原 悠; 砂留 広伸; 佐藤 篤靖; 金子 猛; 平井 豊博

  日本呼吸器学会誌, Mar. 2024

  
• CTを用いた肺移植患者の骨密度の低下とその関連因子の検討

  森 令法; 半田 知宏; 大角 明宏; 池添 浩平; 谷澤 公伸; 魚住 龍史; 田辺 直也; 小熊 毅; 坂本 亮; 濱路 政嗣; 中島 大輔; 豊 洋次郎; 田中 里奈; 山田 義人; 大島 洋平; 佐藤 晋; 福井 基成; 伊達 洋至; 平井 豊博

  移植, Jul. 2024

  
• オンコマインでドライバー遺伝子検出されず,Foundation OneでSCL8A1-ALK融合遺伝子が検出され,アレクチニブが有効であったALK陽性肺腺癌の1例

  名取 大輔; 橋本 健太郎; 吉田 寛; 味水 瞳; 野溝 岳; 吉田 博徳; 小笹 裕晃; 平井 豊博; 吉岡 正博; 金井 雅史; 武藤 学

  肺癌, Oct. 2023

  
• 新規TEAD1阻害薬VT103とDabrafenibの併用はBRAF V600E変異肺癌細胞株のアポトーシスを亢進させる(Novel TEAD1 inhibitor VT103 plus dabrafenib promotes apoptosis in BRAF V600E mutated lung adenocarcinoma cell lines)

  細谷 和貴; 小笹 裕晃; 橋本 健太郎; 吉田 寛; 大木元 達也; 味水 瞳; 船造 智子; 吉田 博徳; 野溝 岳; 辻 貴宏; Tracy Tang T.; 平井 豊博

  日本癌学会総会記事, Sep. 2023

  
• 新規TEAD1阻害薬VT103はALK陽性肺癌細胞株に対するTKIの効果を増幅する(Novel TEAD1 inhibitor VT103 may enhance efficacy of ALK-TKI in lung cancer cell line in vitro and in vivo)

  橋本 健太郎; 小笹 裕晃; 山添 正敏; 吉田 寛; 大木元 達也; 細谷 和貴; 船造 智子; 味水 瞳; 吉田 博徳; 野溝 岳; Tang Tracy T.; 平井 豊博

  日本癌学会総会記事, Sep. 2023

  
• 肺癌転移性脳腫瘍の生体内観察モデルを用いた,新規治療薬の検討

  小笹 裕晃; 細谷 和貴; 辻 貴宏; 味水 瞳; 和氣 弘明; 平井 豊博

  日本呼吸器学会誌, Mar. 2023

  
• 転移性脳腫瘍モデルを用いた転移制御因子の探索

  辻 貴宏; 和氣 弘明; 進藤 麻理子; 加藤 大輔; 大木元 達也; 細谷 和貴; 味水 瞳; 小笹 裕晃; 平井 豊博

  肺癌, Oct. 2021

  
• 二光子顕微鏡による肺癌肝転移モデルの観察

  味水 瞳; 小笹 裕晃; 辻 貴宏; 橋本 健太郎; 吉田 寛; 大木元 達也; 細谷 和貴; 山添 正敏; 船造 智子; 糸谷 涼; 吉田 博徳; 和氣 弘明; 平井 豊博

  日本癌学会総会記事, Sep. 2021

  
• Performance status improvement and advances in systemic treatment after brain metastases resection: a retrospective single-center cohort study of non-small cell lung cancer patients

  Kazutaka Hosoya; Hiroaki Ozasa; Masahiro Tanji; Hiroshi Yoshida; Hitomi Ajimizu; Takahiro Tsuji; Hironori Yoshida; Yukinori Terada; Noritaka Sano; Yohei Mineharu; Susumu Miyamoto; Toyohiro Hirai; Yoshiki Arakawa

  BMC Cancer, 21 Aug. 2024

  
• Lung imaging in COPD and asthma.

  Naoya Tanabe; Hiroaki Nakagawa; Seiichiro Sakao; Yoshiharu Ohno; Kaoruko Shimizu; Hidetoshi Nakamura; Masayuki Hanaoka; Yasutaka Nakano; Toyohiro Hirai

  Respiratory investigation, 29 Aug. 2024

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• Lower skeletal muscle density and airway structure on computed tomography in asthma.

  Yusuke Hayashi; Naoya Tanabe; Kaoruko Shimizu; Tomoki Maetani; Yusuke Shiraishi; Tsuyoshi Oguma; Hironobu Sunadome; Ryo Sakamoto; Atsuyasu Sato; Susumu Sato; Hiroshi Date; Hisako Matsumoto; Toyohiro Hirai

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 22 Aug. 2024

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• Phase angle measured by bioelectrical impedance analysis in patients with chronic obstructive pulmonary disease: Associations with physical inactivity and frailty.

  Ryota Hamada; Naoya Tanabe; Yohei Oshima; Yuji Yoshioka; Tomoki Maetani; Yusuke Shiraishi; Atsuyasu Sato; Susumu Sato; Ryosuke Ikeguchi; Shuichi Matsuda; Toyohiro Hirai

  Respiratory medicine, 21 Aug. 2024

  
• Sleep Restfulness in Patients with Obstructive Sleep Apnea Undergoing Continuous Positive Airway Pressure Therapy.

  Satoshi Hamada; Jumpei Togawa; Hironobu Sunadome; Tadao Nagasaki; Naomi Takahashi; Toyohiro Hirai; Susumu Sato

  Sleep science (Sao Paulo, Brazil), Mar. 2024

  
• Effect of biologic therapy on the humoral immune response to the BNT162b2 vaccine in patients with asthma.

  Masahiro Shirata; Isao Ito; Tsuyoshi Oguma; Tadao Nagasaki; Issei Oi; Nobuyoshi Hamao; Kensuke Nishioka; Toyohiro Hirai

  Respiratory investigation, Nov. 2023

  
• Mucus plugging on computed tomography and the sputum microbiome in patients with asthma, chronic obstructive pulmonary disease, and asthma-COPD overlap.

  Naoya Tanabe; Hisako Matsumoto; Chie Morimoto; Yusuke Hayashi; Ryo Sakamoto; Tsuyoshi Oguma; Tadao Nagasaki; Hironobu Sunadome; Atsuyasu Sato; Susumu Sato; Kai Ohashi; Takamitsu Tsukahara; Toyohiro Hirai

  Allergology international : official journal of the Japanese Society of Allergology, 15 Jul. 2024

  
• Assessment of Anti-Influenza Drug Prescriptions for Postexposure Prophylaxis Against Household Transmission of Influenza Virus

  Masahiro Shirata; Isao Ito; Toyohiro Hirai

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 05 Oct. 2021

  
• Protein C活性は介護施設関連肺炎に特有の予後予測マーカーとなりうるか

  大井 一成; 伊藤 功朗; 濱尾 信叔; 白田 全弘; 西岡 憲亮; 林 康之; 今井 誠一郎; 安友 佳朗; 松本 久子; 平井 豊博; 田辺 直也; 小西 聡史; 門脇 誠三

  日本感染症学会西日本地方会学術集会・日本感染症学会中日本地方会学術集会・日本化学療法学会西日本支部総会プログラム・抄録集, Oct. 2021

  
• Hyperfructosemia in sleep disordered breathing: metabolome analysis of Nagahama study.

  Yoshinari Nakatsuka; Kimihiko Murase; Kazuhiro Sonomura; Yasuharu Tabara; Tadao Nagasaki; Satoshi Hamada; Takeshi Matsumoto; Takuma Minami; Osamu Kanai; Hirofumi Takeyama; Hironobu Sunadome; Naomi Takahashi; Isuzu Nakamoto; Kiminobu Tanizawa; Tomohiro Handa; Taka-Aki Sato; Naoko Komenami; Tomoko Wakamura; Satoshi Morita; Osamu Takeuchi; Takeo Nakayama; Toyohiro Hirai; Yoichiro Kamatani; Fumihiko Matsuda; Kazuo Chin

  Scientific reports, 05 Aug. 2023, Peer-reviewed

  
• Sleep blood pressure measured using a home blood pressure monitor was independently associated with cardiovascular disease incidence: the Nagahama study.

  Yasuharu Tabara; Takeshi Matsumoto; Kimihiko Murase; Kazuya Setoh; Takahisa Kawaguchi; Tomoko Wakamura; Toyohiro Hirai; Kazuo Chin; Fumihiko Matsuda

  Journal of hypertension, 28 May 2024

  
• Quantitative analysis of interstitial lung abnormalities on computed tomography to predict symptomatic radiation pneumonitis after lung stereotactic body radiotherapy.

  Masahiro Yoneyama; Yukinori Matsuo; Noriko Kishi; Ryo Itotani; Tsuyoshi Oguma; Hiroaki Ozasa; Kiminobu Tanizawa; Tomohiro Handa; Toyohiro Hirai; Takashi Mizowaki

  Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 23 Jun. 2024

  
• Computed tomography mucus plugs and airway tree structure in patients with chronic obstructive pulmonary disease: Associations with airflow limitation, health-related independence and mortality.

  Naoya Tanabe; Kaoruko Shimizu; Hiroshi Shima; Nobuyasu Wakazono; Yusuke Shiraishi; Kunihiko Terada; Satoru Terada; Tsuyoshi Oguma; Ryo Sakamoto; Masaru Suzuki; Hironi Makita; Atsuyasu Sato; Susumu Sato; Masaharu Nishimura; Satoshi Konno; Toyohiro Hirai

  Respirology (Carlton, Vic.), 24 Jun. 2024

  
• 当院における胸部悪性腫瘍に対するComprehensive Genomic Profilingの有用性の検証

  住永 圭一郎; 吉田 博徳; 名取 大輔; 島 佑介; 味水 瞳; 野溝 岳; 小笹 裕晃; 阪森 優一; 吉岡 正博; 金井 雅史; 武藤 学; 平井 豊博

  肺癌, Oct. 2023

  
• PD-L1高発現のSTK11/TP53/KRAS変異陽性肺腺癌に対して免疫チェックポイント阻害剤を投与した症例

  吉田 博徳; 橋本 健太郎; 吉田 寛; 味水 瞳; 糸谷 涼; 阪森 優一; 小笹 裕晃; 平井 豊博

  気管支学, Jun. 2023

  
• YAP1やその他の因子はEGFR遺伝子変異陽性肺癌の初期耐性機序と関連する(YAP1 and other factors are associated with initial resistance mechanisms in EGFR mutation-positive lung cancer)

  大木元 達也; 小笹 裕晃; 橋本 健太郎; 吉田 寛; 細谷 和貴; 山添 正敏; 味水 瞳; 船造 智子; 辻 貴宏; 吉田 博徳; 阪森 優一; 平井 豊博

  日本癌学会総会記事, Sep. 2022

  
• 患者由来BRAF V600E変異陽性肺癌細胞株に対し、新規TEAD1阻害薬VT103がアポトーシスを促進する(Novel TEAD1 inhibitor VT103 promotes apoptosis in patient-derived BRAF V600E mutated lung adenocarcinoma cell lines)

  細谷 和貴; 小笹 裕晃; 橋本 健太郎; 吉田 寛; 大木元 達也; 山添 正敏; 味水 瞳; 船造 智子; 辻 貴宏; 吉田 博徳; 阪森 優一; Tracy Tang T.; 平井 豊博

  日本癌学会総会記事, Sep. 2022

  
• YAP1はAKTシグナルを介してROS1肺癌におけるROS1阻害薬からの初期生存に関与する(YAP1 mediates initial cell survival during lorlatinib treatment via AKT signaling in ROS1-rearranged lung cancer)

  山添 正敏; 小笹 裕晃; 辻 貴宏; 船造 智子; 吉田 寛; 橋本 健太郎; 細谷 和貴; 大木元 達也; 味水 瞳; 吉田 博徳; 糸谷 涼; 阪森 優一; 國永 清光; 平井 豊博

  日本癌学会総会記事, Sep. 2022

  
• 多発性の中心型早期肺癌に対し複数回の光線力学的治療を施行した1例

  時任 寛行; 吉田 博徳; 阪森 優一; 小笹 裕晃; 平井 豊博

  気管支学, Sep. 2022

  
• TEAD遺伝子の一塩基多型はEGFR肺癌患者においてEGFRチロシンキナーゼ阻害薬による無増悪生存期間に影響する

  山添 正敏; 小笹 裕晃; 大木元 達也; 細谷 和貴; 味水 瞳; 山本 智子; 辻 貴宏; 糸谷 涼; 吉田 博徳; 阪森 優一; 野溝 岳; 吉田 寛; 橋本 健太郎; 平井 豊博

  日本癌学会総会記事, Sep. 2021

  
• BRAF V600E変異陽性肺癌の分子標的薬耐性に上皮間葉転換(EMT)が関与する

  細谷 和貴; 小笹 裕晃; 橋本 健太郎; 吉田 寛; 大木元 達也; 山添 正敏; 味水 瞳; 船造 智子; 辻 貴宏; 吉田 博徳; 阪森 優一; 平井 豊博

  日本癌学会総会記事, Sep. 2021

  
• CD47のSNPsが肺癌のニボルマブの治療効果に影響を与える

  大木元 達也; 小笹 裕晃; 橋本 健太郎; 吉田 寛; 細谷 和貴; 山添 正敏; 味水 瞳; 船造 智子; 辻 貴宏; 吉田 博徳; 阪森 優一; 平井 豊博

  日本癌学会総会記事, Sep. 2021

  
• 非小細胞肺癌に対する免疫チェックポイント阻害治療中にoligoprogressionを示した病変に対し、外科切除を行った3例

  細谷 和貴; 吉田 博徳; 小笹 裕晃; 糸谷 涼; 阪森 優一; 金 永学; 平井 豊博; 濱路 政嗣; 吉澤 明彦

  肺癌, Jun. 2021

  
• 当院におけるEGFR遺伝子変異陽性肺癌に対するシングルプレックス法とマルチプレックス法の比較検討

  大木元 達也; 金 永学; 小笹 裕晃; 阪森 優一; 吉田 博徳; 糸谷 涼; 山本 智子; 味水 瞳; 山添 正敏; 細谷 和貴; 白波瀬 浩幸; 吉澤 明彦; 伊達 洋至; 平井 豊博

  日本呼吸器学会誌, Apr. 2021

  
• METex14 skipping変異陽性NSCLCの臨床的特徴ならびにオンコマインDxTTとArcherMETの一致率に関する検討

  細谷 和貴; 金 永学; 大木元 達也; 山添 正敏; 味水 瞳; 糸谷 涼; 吉田 博徳; 阪森 優一; 小笹 裕晃; 伊達 洋至; 白波瀬 浩幸; 吉澤 明彦; 平井 豊博

  日本呼吸器学会誌, Apr. 2021

  
• COPD合併進行非小細胞肺癌患者へのCOPD薬物治療の意義(2nd Report)

  國永 清光; 小笹 裕晃; 味水 瞳; 阪森 優一; 吉田 博徳; 糸谷 涼; 野溝 岳; 金 永学; 佐藤 晋; 平井 豊博

  日本呼吸器学会誌, Apr. 2021

  
• ニボルマブで治療された進行非小細胞肺癌の生存転帰に対するPD-L1 SNPsの臨床的意義

  野溝 岳; 吉田 博徳; 小笹 裕晃; 山本 智子; 安田 有斗; 辻 貴宏; 味水 瞳; 山添 正敏; 阪森 優一; 金 永学; 平井 豊博

  日本呼吸器学会誌, Apr. 2021

  
• ROS1陽性肺癌においてYAP1はROS1阻害薬からの初期生存に関与する

  山添 正敏; 小笹 裕晃; 辻 貴宏; 船造 智子; 大木元 達也; 細谷 和貴; 味水 瞳; 安田 有斗; 吉田 博徳; 阪森 優一; 金 永学; 平井 豊博

  日本呼吸器学会誌, Apr. 2021

  
• Current advances in pulmonary functional imaging.

  Hidetoshi Nakamura; Toyohiro Hirai; Hajime Kurosawa; Kazuki Hamada; Kazuto Matsunaga; Kaoruko Shimizu; Satoshi Konno; Shigeo Muro; Koichi Fukunaga; Yasutaka Nakano; Ichiro Kuwahira; Masayuki Hanaoka

  Respiratory investigation, Jan. 2024

  
• 睡眠・呼吸障害 本邦における中等症以上COVID-19の後遺障害の実態調査 睡眠障害について

  佐藤 晋; 高橋 順美; 伊藤 功朗; 田辺 直也; 高松 和史; 福永 興壱; 近藤 康博; 新海 正晴; 小倉 高志; 北 俊之; 高橋 和久; 平井 豊博; 横山 彰仁; 陳 和夫

  日本呼吸器学会誌, Mar. 2023

  
• Associations between Sleep-Disordered Breathing and Serum Uric Acid and Their Sex Differences: The Nagahama Study.

  Hironobu Sunadome; Kimihiko Murase; Yasuharu Tabara; Takeshi Matsumoto; Takuma Minami; Osamu Kanai; Tadao Nagasaki; Naomi Takahashi; Satoshi Hamada; Kiminobu Tanizawa; Jumpei Togawa; Sayaka Uiji; Tomoko Wakamura; Naoko Komenami; Kazuya Setoh; Takahisa Kawaguchi; Satoshi Morita; Yoshimitsu Takahashi; Takeo Nakayama; Toyohiro Hirai; Susumu Sato; Fumihiko Matsuda; Kazuo Chin

  Nutrients, 30 Sep. 2023

  
• Clinical phenotypes of nontuberculous mycobacterial disease by cluster analysis based on pulmonary function

  Nobuyoshi Hamao; Isao Ito; Issei Oi; Masahiro Shirata; Kensuke Nishioka; Yasuyuki Hayashi; Seiichiro Imai; Toyohiro Hirai

  Respiratory Medicine, 01 Apr. 2024

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• Protein C活性は介護施設関連肺炎に特有の予後予測マーカーとなりうるか

  大井 一成; 伊藤 功朗; 濱尾 信叔; 白田 全弘; 西岡 憲亮; 林 康之; 今井 誠一郎; 安友 佳朗; 松本 久子; 平井 豊博; 田辺 直也; 小西 聡史; 門脇 誠三

  日本感染症学会西日本地方会学術集会・日本感染症学会中日本地方会学術集会・日本化学療法学会西日本支部総会プログラム・抄録集, Oct. 2021

  
• Screening of factors inducing alveolar type 1 epithelial cells using human pluripotent stem cells.

  Yuko Ohnishi; Atsushi Masui; Takahiro Suezawa; Ryuta Mikawa; Toyohiro Hirai; Masatoshi Hagiwara; Shimpei Gotoh

  Stem cell reports, 09 Apr. 2024

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• Associations of fractional exhaled nitric oxide with airway dimension and mucus plugs on ultra-high-resolution computed tomography in former smokers and nonsmokers with asthma.

  Yusuke Hayashi; Naoya Tanabe; Hisako Matsumoto; Kaoruko Shimizu; Ryo Sakamoto; Tsuyoshi Oguma; Hironobu Sunadome; Atsuyasu Sato; Susumu Sato; Toyohiro Hirai

  Allergology international : official journal of the Japanese Society of Allergology, 24 Feb. 2024

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• 関節リウマチ患者における新型コロナウイルスワクチン接種後の液性免疫応答に関する検討

  白田 全弘; 伊藤 功朗; 大井 一成; 濱尾 信叔; 西岡 憲亮; 林 康之; 平井 豊博; 田中 真生; 村上 孝作; 村田 浩一; 伊藤 宣; 橋本 求

  感染症学雑誌, Mar. 2022

  
• Investigation of predictors for in-hospital death or long-term hospitalization in community-acquired pneumonia with risk factors for aspiration

  Issei Oi; Isao Ito; Naoya Tanabe; Satoshi Konishi; Yumiko Ibi; Yu Hidaka; Nobuyoshi Hamao; Masahiro Shirata; Kensuke Nishioka; Seiichiro Imai; Yoshiro Yasutomo; Seizo Kadowaki; Toyohiro Hirai

  European Clinical Respiratory Journal, 04 Apr. 2024

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• Associations between Nocturnal Hypoxemia and Retinal Nerve Fiber Layer Thinning: The Nagahama Study.

  Tadao Nagasaki; Masahiro Miyake; Susumu Sato; Kimihiko Murase; Takahisa Kawaguchi; Takeshi Matsumoto; Yoshinari Nakatsuka; Yuki Mori; Hanako Ohashi Ikeda; Hironobu Sunadome; Satoshi Hamada; Naomi Takahashi; Jumpei Togawa; Osamu Kanai; Sayaka Uiji; Tomoko Wakamura; Yasuharu Tabara; Akitaka Tsujikawa; Fumihiko Matsuda; Toyohiro Hirai; Kazuo Chin

  Annals of the American Thoracic Society, 19 Jan. 2024

  
• Quantification of airway structures by persistent homology

  Shizuo Kaji; Naoya Tanabe; Tomoki Maetani; Yusuke Shiraishi; Ryo Sakamoto; Tsuyoshi Oguma; Katsuhiro Suzuki; Kunihiko Terada; Motonari Fukui; Shigeo Muro; Susumu Sato; Toyohiro Hirai

  IEEE Transactions on Medical Imaging, 2024

  
• Successful treatment of lung cancer coexisting with B‑cell lymphoma with pembrolizumab following rituximab‑included chemotherapy: A case report

  Daisuke Natori; Hiroaki Ozasa; Yusuke Shima; Chisaki Mizumoto; Keiichiro Suminaga; Takashi Nomizo; Hitomi Ajimizu; Hironori Yoshida; Toyohiro Hirai

  Molecular and Clinical Oncology, 23 Feb. 2024

  
• Variation in information needs of patients with interstitial lung disease and their family caregivers according to long-term oxygen therapy: A descriptive study

  Ryuhei Sato; Tomohiro Handa; Kiminobu Tanizawa; Toyohiro Hirai

  BMC Pulmonary Medicine, Dec. 2023, Peer-reviewed

  
• Longitudinal changes in respiratory reactance in patients with COPD: associations with longitudinal change in air-trapping, exacerbations, and mortality.

  Yi Zhang; Naoya Tanabe; Susumu Sato; Yusuke Shiraishi; Tomoki Maetani; Ryo Sakamoto; Atsuyasu Sato; Shigeo Muro; Toyohiro Hirai

  Respiratory physiology & neurobiology, 16 Jan. 2024

  
• Artificial intelligence-based analysis of the spatial distribution of abnormal computed tomography patterns in SARS-CoV-2 pneumonia: association with disease severity.

  Yusuke Kataoka; Naoya Tanabe; Masahiro Shirata; Nobuyoshi Hamao; Issei Oi; Tomoki Maetani; Yusuke Shiraishi; Kentaro Hashimoto; Masatoshi Yamazoe; Hiroshi Shima; Hitomi Ajimizu; Tsuyoshi Oguma; Masahito Emura; Kazuo Endo; Yoshinori Hasegawa; Tadashi Mio; Tetsuhiro Shiota; Hiroaki Yasui; Hitoshi Nakaji; Michiko Tsuchiya; Keisuke Tomii; Toyohiro Hirai; Isao Ito

  Respiratory research, 10 Jan. 2024

  
• Pharmacokinetics of GS-441524, the active metabolite of remdesivir, in patients receiving continuous renal replacement therapy: A case series.

  Asami Nishikawa; Isao Ito; Atsushi Yonezawa; Kotaro Itohara; Takeshi Matsubara; Yuki Sato; Katsuyuki Matsumura; Satoshi Hamada; Naoya Tanabe; Shinichi Kai; Eishi Imoto; Kohei Yoshikawa; Shigeru Ohtsuru; Motoko Yanagita; Toyohiro Hirai; Tomohiro Terada

  Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 21 Oct. 2023

  
• Sputum microbiota and inflammatory subtypes in asthma, COPD, and its overlap.

  Chie Morimoto; Hisako Matsumoto; Natsuko Nomura; Hironobu Sunadome; Tadao Nagasaki; Susumu Sato; Atsuyasu Sato; Tsuyoshi Oguma; Isao Ito; Mariko Kogo; Keisuke Tomii; Tomoko Tajiri; Kai Ohashi; Takamitsu Tsukahara; Toyohiro Hirai

  The journal of allergy and clinical immunology. Global, Feb. 2024

  
• A reference equation for lung volume on computed tomography in Japanese middle-aged and elderly adults.

  Naoya Tanabe; Susumu Sato; Takafumi Shimada; Shizuo Kaji; Yusuke Shiraishi; Satoru Terada; Tomoki Maetani; Fumi Mochizuki; Kaoruko Shimizu; Masaru Suzuki; Shotaro Chubachi; Kunihiko Terada; Kazuya Tanimura; Ryo Sakamoto; Tsuyoshi Oguma; Atsuyasu Sato; Megumi Kanasaki; Shigeo Muro; Izuru Masuda; Hiroaki Iijima; Toyohiro Hirai

  Respiratory investigation, 14 Dec. 2023

  
• Increased blood eosinophils and airflow obstruction as new-onset asthma predictors in the elderly: The Nagahama study.

  Kenta Nishi; Tadao Nagasaki; Hisako Matsumoto; Tsuyoshi Oguma; Satoru Terada; Natsuko Nomura; Mariko Kogo; Noriyuki Tashima; Hironobu Sunadome; Kimihiko Murase; Takeshi Matsumoto; Takahisa Kawaguchi; Yasuharu Tabara; Fumihiko Matsuda; Susumu Sato; Kazuo Chin; Toyohiro Hirai

  Allergology international : official journal of the Japanese Society of Allergology, 23 Nov. 2023

  
• A Unique Side Effect Associated With Continuous Positive Airway Pressure Therapy: Right-Sided Edematous Change and Pleural Effusion.

  Satoshi Hamada; Toyohiro Hirai; Susumu Sato

  Archivos de bronconeumologia, 10 Nov. 2023

  
• Association between blood eosinophil count and small airway eosinophils in smokers with and without COPD.

  Tomoki Maetani; Naoya Tanabe; Atsuyasu Sato; Yusuke Shiraishi; Ryo Sakamoto; Emiko Ogawa; Hiroaki Sakai; Hisako Matsumoto; Susumu Sato; Hiroshi Date; Toyohiro Hirai; Shigeo Muro

  ERJ open research, Sep. 2023

  
• Mode Selection for Titrating Continuous Positive Airway Pressure.

  Satoshi Hamada; Toyohiro Hirai; Susumu Sato

  Internal medicine (Tokyo, Japan), 23 Aug. 2023

  
• Combination therapy with EGFR tyrosine kinase inhibitors and TEAD inhibitor increases tumor suppression effects in EGFR mutation-positive lung cancer

  Tatsuya Ogimoto; Hiroaki Ozasa; Takahiro Tsuji; Tomoko Funazo; Masatoshi Yamazoe; Kentaro Hashimoto; Hiroshi Yoshida; Kazutaka Hosoya; Hitomi Ajimizu; Takashi Nomizo; Hironori Yoshida; Masatsugu Hamaji; Toshi Menju; Akihiko Yoshizawa; Hiroshi Date; Toyohiro Hirai

  Molecular Cancer Therapeutics, 06 Dec. 2023

  
• Evaluation of Bone Mineral Density in Lung Transplant Recipients by Chest Computed Tomography

  Ryobu Mori; Tomohiro Handa; Akihiro Ohsumi; Kohei Ikezoe; Kiminobu Tanizawa; Ryuji Uozumi; Naoya Tanabe; Tsuyoshi Oguma; Ryo Sakamoto; Masatsugu Hamaji; Daisuke Nakajima; Yojiro Yutaka; Satona Tanaka; Yoshito Yamada; Yohei Oshima; Susumu Sato; Motonari Fukui; Hiroshi Date; Toyohiro Hirai

  Respiration, 05 Dec. 2023

  
• Impact of wearing a surgical facemask during exercise on dyspnea in patients with chronic pulmonary infections: A randomized crossover study

  Masahiro Shirata; Kensuke Nishioka; Nobuyoshi Hamao; Issei Oi; Yu Hidaka; Yumiko Ibi; Seiichiro Imai; Susumu Sato; Toyohiro Hirai; Isao Ito

  Respiratory Medicine, Dec. 2023

  
• A phase II study of low starting dose of afatinib as first-line treatment in patients with EGFR mutation-positive non-small-cell lung cancer (KTORG1402).

  Toshihide Yokoyama; Hiroshige Yoshioka; Daichi Fujimoto; Yoshiki Demura; Katsuya Hirano; Takahiro Kawai; Ryogo Kagami; Yasuyoshi Washio; Tadashi Ishida; Mariko Kogo; Keisuke Tomii; Takehiro Okuno; Masaya Akai; Masataka Hirabayashi; Takashi Nishimura; Yasuharu Nakahara; Young Hak Kim; Chisato Miyakoshi; Kenichi Yoshimura; Toyohiro Hirai

  Lung cancer (Amsterdam, Netherlands), Sep. 2019

  
• Quantitative Evaluation of Changes in Three-Dimensional CT Density Distributions in Pulmonary Alveolar Proteinosis after GM-CSF Inhalation.

  Miku Oda; Kentaro Yamaura; Haruyuki Ishii; Nobutaka Kitamura; Ryushi Tazawa; Mitsuhiro Abe; Koichiro Tatsumi; Ryosuke Eda; Shotaro Kondoh; Konosuke Morimoto; Takeshi Tanaka; Etsuro Yamaguchi; Ayumu Takahashi; Shinyu Izumi; Haruhito Sugiyama; Atsushi Nakagawa; Keisuke Tomii; Masaru Suzuki; Satoshi Konno; Shinya Ohkouchi; Naoki Tode; Tomohiro Handa; Toyohiro Hirai; Yoshikazu Inoue; Toru Arai; Katsuaki Asakawa; Takahiro Tanaka; Toshinori Takada; Hirofumi Nonaka; Koh Nakata

  Respiration; international review of thoracic diseases, 09 Dec. 2022

  
• 睡眠・呼吸障害 持続性心房細動に対して高周波カテーテルアブレーションが施行された患者群における睡眠時無呼吸,術後の心房細動の再発および客観的睡眠時間の関連

  南 卓馬; 吉澤 尚志; 村瀬 公彦; 田中 宗和; 相澤 卓範; 山上 新太郎; 小正 晃裕; 静田 聡; 佐藤 晋; 平井 豊博; 木村 剛; 陳 和夫

  日本呼吸器学会誌, Mar. 2023

  
• Cryptotanshinone is a candidate therapeutic agent for interstitial lung disease associated with a BRICHOS-domain mutation of SFTPC

  Motoyasu Hosokawa; Ryuta Mikawa; Atsuko Hagiwara; Yukiko Okuno; Tomonari Awaya; Yuki Yamamoto; Senye Takahashi; Haruka Yamaki; Mitsujiro Osawa; Yasuhiro Setoguchi; Megumu K. Saito; Shinji Abe; Toyohiro Hirai; Shimpei Gotoh; Masatoshi Hagiwara

  iScience, Aug. 2023

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• Impact of methotrexate on humoral and cellular immune responses to SARS-CoV-2 mRNA vaccine in patients with rheumatoid arthritis.

  Masahiro Shirata; Isao Ito; Masao Tanaka; Koichi Murata; Kosaku Murakami; Hiroyuki Ikeda; Issei Oi; Nobuyoshi Hamao; Kensuke Nishioka; Yasuyuki Hayashi; Miki Nagao; Motomu Hashimoto; Hiromu Ito; Hideki Ueno; Akio Morinobu; Toyohiro Hirai

  Clinical and experimental medicine, 16 Aug. 2023

  
• Association of lower plasma citric acid with prolonged cough: the Nagahama study.

  Satoru Terada; Hisako Matsumoto; Kenta Nishi; Mariko Kogo; Natsuko Nomura; Noriyuki Tashima; Chie Morimoto; Hironobu Sunadome; Tadao Nagasaki; Tsuyoshi Oguma; Yoshinari Nakatsuka; Kimihiko Murase; Takahisa Kawaguchi; Yasuharu Tabara; Kazuhiro Sonomura; Fumihiko Matsuda; Kazuo Chin; Toyohiro Hirai

  Scientific reports, 25 Aug. 2023

  
• Longitudinal Changes and Association of Respiratory Symptoms with Preserved Ratio Impaired Spirometry (PRISm): The Nagahama Study.

  Mariko Kogo; Susumu Sato; Shigeo Muro; Hisako Matsumoto; Natsuko Nomura; Tsuyoshi Oguma; Hironobu Sunadome; Tadao Nagasaki; Kimihiko Murase; Takahisa Kawaguchi; Yasuharu Tabara; Fumihiko Matsuda; Kazuo Chin; Toyohiro Hirai

  Annals of the American Thoracic Society, 10 Aug. 2023

  
• CD47 polymorphism for predicting nivolumab benefit in patients with advanced non‑small‑cell lung cancer

  Tatsuya Ogimoto; Hiroaki Ozasa; Hironori Yoshida; Takashi Nomizo; Tomoko Funazo; Hiroshi Yoshida; Kentaro Hashimoto; Kazutaka Hosoya; Masatoshi Yamazoe; Hitomi Ajimizu; Takahiro Tsuji; Yuichi Sakamori; Kiyomitsu Kuninaga; Satoshi Morita; Toyohiro Hirai

  Oncology Letters, 10 Jul. 2023

  
• Residual excessive daytime sleepiness in patients with sleep apnea syndrome receiving continuous positive airway pressure in Japan: A single-center study.

  Satoshi Hamada; Jumpei Togawa; Hironobu Sunadome; Tadao Nagasaki; Naomi Takahashi; Toyohiro Hirai; Susumu Sato

  Respiratory investigation, 16 Jun. 2023

  
• Good clinical response achieved by changing servo-ventilation devices in a patient with central sleep apnea: a case report.

  Satoshi Hamada; Jumpei Togawa; Hironobu Sunadome; Tadao Nagasaki; Toyohiro Hirai; Susumu Sato

  Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 21 Apr. 2023

  
• 当院で脳死肺移植登録を行った同種造血幹細胞移植後晩期非感染性呼吸器合併症症例の待機予後

  池上 直弥; 半田 知宏; 大角 明宏; 近藤 忠一; 木下 秀之; 吉澤 明彦; 坂本 亮; 濱路 政嗣; 中島 大輔; 山田 義人; 豊 洋次郎; 田中 里奈; 伊藤 功朗; 佐藤 晋; 田辺 直也; 谷澤 公伸; 池添 浩平; 芳川 豊史; 伊達 洋至; 平井 豊博

  移植, Apr. 2023

  
• Effects of using in-line bacterial filters with continuous positive airway pressure devices in patients with sleep disordered breathing.

  Satoshi Hamada; Jumpei Togawa; Hironobu Sunadome; Tadao Nagasaki; Naomi Takahashi; Toyohiro Hirai; Susumu Sato

  Respiratory investigation, Jan. 2023

  
• 呼吸器関連資格に関するアンケート調査の結果報告

  高橋 順美; 佐藤 晋; 平井 豊博; 陳 和夫

  日本呼吸ケア・リハビリテーション学会誌, Dec. 2022

  
• COPD患者における肺過膨張,呼吸筋力と胸部CTで定量評価した肺気腫,気道病変との関連

  白石 祐介; 田辺 直也; 金崎 雅史; 前谷 知毅; 島 寛; 濱川 瑶子; 寺田 邦彦; 佐藤 晋; 平井 豊博

  日本呼吸ケア・リハビリテーション学会誌, Oct. 2022

  
• 持続陽圧呼吸療法装置に装着されたバクテリアフィルターの影響の検討

  濱田 哲; 十川 純平; 砂留 広伸; 長崎 忠雄; 高橋 順美; 平井 豊博; 佐藤 晋

  日本呼吸ケア・リハビリテーション学会誌, Oct. 2022

  
• 睡眠時無呼吸症候群患者における持続陽圧呼吸装置使用状況と日中の眠気や睡眠休養感との関係の検討

  濱田 哲; 高橋 順美; 十川 純平; 砂留 広伸; 長崎 忠雄; 平井 豊博; 佐藤 晋

  日本呼吸ケア・リハビリテーション学会誌, Oct. 2022

  
• 気管支喘息(成人):長期追跡調査、増悪因子 高齢者・非高齢者における喘息発症因子の差異 ながはま疫学研究

  西 健太; 長崎 忠雄; 松本 久子; 小熊 毅; 寺田 悟; 野村 奈都子; 古郷 摩利子; 砂留 広伸; 村瀬 公彦; 川口 喬久; 田原 康玄; 松田 文彦; 佐藤 晋; 陳 和夫; 平井 豊博

  アレルギー, Aug. 2022

  
• 日本におけるCOPDと睡眠呼吸障害の関連 ながはまコホート研究より

  長崎 忠雄; 佐藤 晋; 村瀬 公彦; 松本 健; 濱田 哲; 砂留 弘伸; 十川 純平; 高橋 順美; 田原 康玄; 松田 文彦; 平井 豊博; 陳 和夫

  日本睡眠学会定期学術集会プログラム・抄録集, Jun. 2022

  
• 持続陽圧呼吸療法装置の機種変更による治療効果の違いに関する検討

  吉野 杏菜; 濱田 哲; 横溝 綾香; 増田 優里; 今井 理恵; 石川 裕子; 上田 和幸; 十川 純平; 砂留 広伸; 長崎 忠雄; 平井 豊博; 佐藤 晋

  日本睡眠学会定期学術集会プログラム・抄録集, Jun. 2022

  
• 加速度センサー内臓パルスオキシメーターPULSOX-Me500とアクチグラフで測定された活動量の違いに関する検討

  増田 優里; 濱田 哲; 横溝 綾香; 吉野 杏菜; 今井 理恵; 石川 裕子; 上田 和幸; 十川 純平; 砂留 広伸; 長崎 忠雄; 平井 豊博; 佐藤 晋

  日本睡眠学会定期学術集会プログラム・抄録集, Jun. 2022

  
• 持続陽圧呼吸療法開始直後に心室性不整脈の増悪を来した特発性拡張型心筋症の一例

  横溝 綾香; 濱田 哲; 吉野 杏菜; 増田 優里; 今井 理恵; 石川 裕子; 上田 和幸; 十川 純平; 砂留 広伸; 長崎 忠雄; 平井 豊博; 佐藤 晋

  日本睡眠学会定期学術集会プログラム・抄録集, Jun. 2022

  
• Other iatrogenic immunodeficiency-associated lymphoproliferative disorders in a patient with anti-melanoma differentiation-associated gene 5-positive dermatomyositis: A case report and systematic literature review.

  Nozomi Nishimura; Takafumi Niwamoto; Yasuyuki Arai; Ran Nakashima; Kazuhiro Terada; Akihiko Yoshizawa; Ryo Sakamoto; Kiminobu Tanizawa; Tomohiro Handa; Akio Morinobu; Toyohiro Hirai

  International journal of rheumatic diseases, Jun. 2023

  
• 肺Mycobacterium shimoidei感染症 1例報告と日本文献による考察(PULMONARY MYCOBACTERIUM SHIMOIDEI INFECTION: A CASE REPORT AND REVIEW OF JAPANESE LITERATURE)

  今井 誠一郎; 伊藤 功朗; 平井 豊博

  結核, Sep. 2022

  
• 高齢で緩徐に発病したMycobacterium shimoideiの一例

  今井 誠一郎; 伊藤 功朗; 平井 豊博

  結核, Jun. 2022

  
• 肺非結核抗酸菌症における低体重に関わる因子の検討

  濱尾 信叔; 伊藤 功朗; 大井 一成; 白田 全弘; 西岡 憲亮; 林 康之; 今井 誠一郎; 平井 豊博

  感染症学雑誌, Mar. 2022

  
• 肺非結核抗酸菌症患者のるい痩に関わる因子の検討

  濱尾 信叔; 伊藤 功朗; 大井 一成; 白田 全弘; 西岡 憲亮; 林 康之; 今井 誠一郎; 平井 豊博

  日本内科学会雑誌, Feb. 2022

  
• 肺NTM症における呼吸機能検査を用いたクラスター解析

  濱尾 信叔; 伊藤 功朗; 西岡 憲亮; 白田 全弘; 大井 一成; 今井 誠一郎; 平井 豊博

  日本呼吸器学会誌, Apr. 2021

  
• Association of age with computed tomography airway tree morphology in male and female never smokers without lung disease history.

  Satoru Terada; Naoya Tanabe; Tomoki Maetani; Yusuke Shiraishi; Ryo Sakamoto; Hiroshi Shima; Tsuyoshi Oguma; Atsuyasu Sato; Megumi Kanasaki; Izuru Masuda; Susumu Sato; Toyohiro Hirai

  Respiratory medicine, Aug. 2023

  
• Changes in mortality among patients with chronic obstructive pulmonary disease from the 1990s to the 2000s: a pooled analysis of two prospective cohort studies.

  Susumu Sato; Toru Oga; Shigeo Muro; Kazuya Tanimura; Naoya Tanabe; Koichi Nishimura; Toyohiro Hirai

  BMJ open, 07 Mar. 2023

  
• An observational cohort study of interstitial lung abnormalities (ILAs) in a large Japanese health screening population (Kumamoto ILA study in Japan: KILA-J)

  Kazuya Ichikado; Hidenori Ichiyasu; Kazuhiro Iyonaga; Kodai Kawamura; Noritaka Higashi; Takeshi Johkoh; Kiminori Fujimoto; Jun Morinaga; Minoru Yoshida; Katsuhiko Mitsuzaki; Moritaka Suga; Naoya Tanabe; Tomohiro Handa; Toyohiro Hirai; Takuro Sakagami

  BMC Pulmonary Medicine, 08 Jun. 2023

  
• Sleep-related factors associated with masked hypertension: the Nagahama study.

  Yasuharu Tabara; Takeshi Matsumoto; Kimihiko Murase; Kazuya Setoh; Takahisa Kawaguchi; Takeo Nakayama; Tomoko Wakamura; Toyohiro Hirai; Kazuo Chin; Fumihiko Matsuda

  Journal of hypertension, 16 May 2023

  
• iPSC-derived mesenchymal cells that support alveolar organoid development

  Koji Tamai; Kouji Sakai; Haruka Yamaki; Keita Moriguchi; Koichi Igura; Shotaro Maehana; Takahiro Suezawa; Kazuaki Takehara; Masatoshi Hagiwara; Toyohiro Hirai; Shimpei Gotoh

  Cell Reports Methods, Oct. 2022

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• Evaluation of elevated plasma fatty acids as relevant factors for adult-onset asthma: The Nagahama Study.

  Noriyuki Tashima; Hisako Matsumoto; Kenta Nishi; Satoru Terada; Mariko Kogo; Natsuko Nomura; Chie Morimoto; Hironobu Sunadome; Tadao Nagasaki; Tsuyoshi Oguma; Yoshinari Nakatsuka; Kimihiko Murase; Takahisa Kawaguchi; Yasuharu Tabara; Kazuo Chin; Kazuhiro Sonomura; Fumihiko Matsuda; Toyohiro Hirai

  Allergology international : official journal of the Japanese Society of Allergology, 15 May 2023

  
• Importance of mucus burden and mucociliary impairment in asthma.

  Natsuko Nomura; Hisako Matsumoto; Hironobu Sunadome; Tsuyoshi Oguma; Toyohiro Hirai

  The Journal of allergy and clinical immunology, May 2023

  
• Roles of Staphylococcus aureus and sensitization to staphylococcal enterotoxin in bronchiectasis.

  Chie Morimoto; Hisako Matsumoto; Isao Ito; Tadao Nagaski; Tsuyoshi Oguma; Toyohiro Hirai

  Respiratory investigation, Jan. 2023

  
• Stronger Associations of Centrilobular Than Paraseptal Emphysema With Longitudinal Changes in Diffusing Capacity and Mortality in COPD.

  Yusuke Shiraishi; Naoya Tanabe; Kaoruko Shimizu; Akira Oguma; Hiroshi Shima; Ryo Sakamoto; Hajime Yamazaki; Tsuyoshi Oguma; Atsuyasu Sato; Masaru Suzuki; Hironi Makita; Shigeo Muro; Masaharu Nishimura; Susumu Sato; Satoshi Konno; Toyohiro Hirai

  Chest, 31 Jan. 2023

  
• Protocol for cell-type-specific tissue reconstruction in the murine lung fibrogenic microenvironment.

  Koichi Hasegawa; Ryo Miyata; Toshi Menju; Toyohiro Hirai; Hiroshi Date; Atsuyasu Sato

  STAR protocols, 25 Jan. 2023

  
• Factors associated with the development of bacterial pneumonia related to seasonal influenza virus infection: a study using a large-scale health insurance claim database

  Masahiro Shirata; Isao Ito; Taisuke Jo; Tomohide Iwao; Issei Oi; Nobuyoshi Hamao; Kensuke Nishioka; Hayato Yamana; Takahide Nagase; Hideo Yasunaga; Toyohiro Hirai

  Open Forum Infectious Diseases, 21 Apr. 2023

  
• Outcomes of immune checkpoint inhibitors for postoperative recurrence of non-small cell lung cancer

  Itsuki Yuasa; Masatsugu Hamaji; Hiroaki Ozasa; Yuichi Sakamori; Hironori Yoshida; Yojiro Yutaka; Toshi Menju; Toyohiro Hirai; Hiroshi Date

  General Thoracic and Cardiovascular Surgery, 2023

  
• Combination bezafibrate and nivolumab treatment of patients with advanced non-small cell lung cancer.

  Kentaro Tanaka; Kenji Chamoto; Sho Saeki; Ryusuke Hatae; Yuki Ikematsu; Kazuko Sakai; Nobuhisa Ando; Kazuhiro Sonomura; Shinsuke Kojima; Masanori Taketsuna; Young Hak Kim; Hironori Yoshida; Hiroaki Ozasa; Yuichi Sakamori; Tomoko Hirano; Fumihiko Matsuda; Toyohiro Hirai; Kazuto Nishio; Takuro Sakagami; Masanori Fukushima; Yoichi Nakanishi; Tasuku Honjo; Isamu Okamoto

  Science translational medicine, 14 Dec. 2022

  
• クラスター解析による新型コロナウイルス患者の分類

  林 康之; 伊藤 功朗; 小嶋 徹; 富井 啓介; 中川 淳; 大塚 浩二郎; 杉田 孝和; 福井 基成; 井上 大生; 長谷川 吉則; 安井 浩明; 藤田 浩平; 石田 直; 伊藤 明広; 北 英夫; 加持 雄介; 土谷 美知子; 冨岡 洋海; 西村 尚志; 平林 正孝; 遠藤 和夫; 江村 正仁; 山本 舜悟; 塚尾 仁一; 平井 豊博; 関西COVID-19研究チーム

  日本呼吸器学会誌, Apr. 2022

  
• COVID-19肺炎における中枢側有意の浸潤影と予後に関する検討

  濱尾 信叔; 伊藤 功朗; 江村 正仁; 山本 舜悟; 長谷川 吉則; 山添 正敏; 遠藤 和夫; 平林 正孝; 田辺 直也; 半田 知宏; 大井 一成; 白田 全弘; 西岡 憲亮; 平井 豊博

  日本呼吸器学会誌, Apr. 2022

  
• COVID-19肺炎の臨床像 多施設共同研究から見えてきたもの

  伊藤 功朗; 石田 直; 伊藤 明広; 遠藤 和夫; 平林 正孝; 江村 正仁; 山本 舜悟; 小嶋 徹; 塚尾 仁一; 富井 啓介; 中川 淳; 大塚 浩二郎; 赤井 雅也; 大井 昌寛; 杉田 孝和; 福井 基成; 井上 大生; 長谷川 吉則; 高橋 憲一; 安井 浩明; 藤田 浩平; 北 英夫; 加持 雄介; 土谷 美知子; 冨岡 洋海; 山田 孝; 寺田 悟; 中治 仁志; 西村 尚志; 大井 一成; 濱尾 信叔; 白田 全弘; 西岡 憲亮; 林 康之; 山添 正敏; 白石 祐介; 大木元 達也; 細谷 和貴; 味水 瞳; 島 寛; 長谷川 浩一; 田辺 直也; 平井 豊博

  日本化学療法学会雑誌, Mar. 2022

  
• 市中肺炎全体における新型コロナウイルス肺炎の位置付け 細菌性肺炎との比較による検討

  西岡 憲亮; 伊藤 功朗; 石田 直; 伊藤 明広; 小嶋 徹; 富井 啓介; 中川 淳; 大塚 浩二郎; 杉田 孝和; 福井 基成; 井上 大生; 長谷川 吉則; 安井 浩明; 藤田 浩平; 北 英夫; 加持 雄介; 土谷 美知子; 冨岡 洋海; 平井 豊博; 平林 正孝; 遠藤 和夫; 江村 正仁; 山本 舜悟; 塚尾 仁一; 赤井 雅也; 大井 昌寛; 高橋 憲一; 山田 孝; 中治 仁志; 白石 祐介; 山添 正敏; 大木元 達也; 細谷 和貴; 味水 瞳; 寺田 悟; 島 寛; 大井 一成; 濱尾 信叔; 白田 全弘; 林 康之; 田辺 直也

  感染症学雑誌, Mar. 2022

  
• Recurrence patterns and progression-free survival after chemoradiotherapy with or without consolidation durvalumab for stage III non-small cell lung cancer.

  Noriko Kishi; Yukinori Matsuo; Takashi Shintani; Masakazu Ogura; Takamasa Mitsuyoshi; Norio Araki; Kota Fujii; Setsuko Okumura; Kiyoshi Nakamatsu; Takahiro Kishi; Tomoko Atsuta; Takashi Sakamoto; Shuji Ohtsu; Tomohiro Katagiri; Masaru Narabayashi; Satsuki Fujishiro; Yusuke Iizuka; Hiroaki Ozasa; Toyohiro Hirai; Takashi Mizowaki

  Journal of radiation research, 22 Sep. 2022

  
• Centrilobular Emphysema Is Associated with Pectoralis Muscle Reduction in Current Smokers without Airflow Limitation.

  Tomoki Maetani; Naoya Tanabe; Yusuke Shiraishi; Takafumi Shimada; Satoru Terada; Hiroshi Shima; Fumi Mochizuki; Ryo Sakamoto; Shizuo Kaji; Tsuyoshi Oguma; Susumu Sato; Hiroaki Iijima; Izuru Masuda; Toyohiro Hirai

  Respiration; international review of thoracic diseases, 23 Jan. 2023

  
• Chronic obstructive pulmonary disease features in patients visiting primary respiratory clinic and tertiary hospital in Japan.

  Kunihiko Terada; Naoya Tanabe; Yusuke Shiraishi; Yoko Hamakawa; Hiroshi Shima; Tomoki Maetani; Satoru Terada; Susumu Sato; Masashi Kanezaki; Toyohiro Hirai

  Respiratory investigation, Jan. 2023

  
• The Effects of Changing Continuous Positive Airway Pressure Devices in Japanese Patients with Obstructive Sleep Apnea: A Case Series.

  Satoshi Hamada; Jumpei Togawa; Hironobu Sunadome; Tadao Nagasaki; Toyohiro Hirai; Susumu Sato

  Internal medicine (Tokyo, Japan), 07 Dec. 2022

  
• Differential role of mucus plugs in asthma: Effects of smoking and association with airway inflammation.

  Akira Oguma; Kaoruko Shimizu; Hirokazu Kimura; Naoya Tanabe; Susumu Sato; Isao Yokota; Michiko Takimoto-Sato; Machiko Matsumoto-Sasaki; Yuki Abe; Nozomu Takei; Houman Goudarzi; Masaru Suzuki; Hironi Makita; Toyohiro Hirai; Masaharu Nishimura; Satoshi Konno

  Allergology international : official journal of the Japanese Society of Allergology, 16 Nov. 2022

  
• Early chronic obstructive pulmonary disease: Associations of two spirometry criteria with clinical features.

  Fumi Mochizuki; Naoya Tanabe; Hiroaki Iijima; Takafumi Shimada; Yusuke Shiraishi; Tomoki Maetani; Hajime Yamazaki; Kaoruko Shimizu; Masaru Suzuki; Shotaro Chubachi; Hiroichi Ishikawa; Takashi Naito; Hironori Masuko; Tohru Sakamoto; Izuru Masuda; Susumu Sato; Nobuyuki Hizawa; Toyohiro Hirai

  Respiratory medicine, 2022

  
• Development of airflow limitation, dyspnoea, and both in the general population: the Nagahama study.

  Mariko Kogo; Susumu Sato; Shigeo Muro; Hisako Matsumoto; Natsuko Nomura; Noriyuki Tashima; Tsuyoshi Oguma; Hironobu Sunadome; Tadao Nagasaki; Kimihiko Murase; Takahisa Kawaguchi; Yasuharu Tabara; Fumihiko Matsuda; Kazuo Chin; Toyohiro Hirai

  Scientific reports, 21 Nov. 2022

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• LIFE SPACE ACTIVITY IN THE PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

  Hamakawa Yoko; Sato Susumu; Watanabe Aya; Mizutani Tatsushi; Uemasu Kiyoshi; Tanabe Naoya; Sato Atsuyasu; Hirai Toyohiro

  RESPIROLOGY, Nov. 2018, Peer-reviewed

  
• LOWER SERUM IMMUNOGLOBULIN FREE LIGHT CHAIN PREDICTS EXACERBATION RISK IN PATIENTS WITH COPD

  Tanimura Kazuya; Sato Susumu; Sato Atsuyasu; Hasegawa Koichi; Uemasu Kiyoshi; Hamakawa Yoko; Kato Motokazu; Hirai Toyohiro; Muro Shigeo

  RESPIROLOGY, Nov. 2018, Peer-reviewed

  
• QUANTITATIVE ASSESSMENT OF AIRWAY STRUCTURE USING ULTRA-HIGH RESOLUTION COMPUTED TOMOGRAPHY

  Shima Hiroshi; Tanabe Naoya; Oguma Tsuyoshi; Sato Susumu; Kozawa Satoshi; Kubo Takeshi; Koizumi Koji; Sato Atsuyasu; Togashi Kaori; Hirai Toyohiro

  RESPIROLOGY, Nov. 2018, Peer-reviewed

  
• Association of airways visibility on computed tomography with symptoms and lung function in COPD

  Tanabe Naoya; Sato Susumu; Muro Shigeo; Oguma Tsuyoshi; Sato Atsuyasu; Hirai Toyohiro

  EUROPEAN RESPIRATORY JOURNAL, 15 Sep. 2018, Peer-reviewed

  
• Protease anti-protease imbalance and small airways disease in COPD

  Tanabe Naoya; Sato Atsuyasu; Mizutani Tatsushi; Hamakawa Yoko; Uemasu Kiyoshi; Sato Susumu; Muro Shigeo; Hirai Toyohiro

  EUROPEAN RESPIRATORY JOURNAL, 15 Sep. 2018, Peer-reviewed

  
• Lung function decline in sarcoidosis

  Kiminobu Tanizawa; Tomohiro Handa; Sonoko Nagai; Kohei Ikezoe; Takeshi Kubo; Takafumi Yokomatsu; Seigen Ueda; Yasutaka Fushimi; Shumpei Ogino; Kizuku Watanabe; Yoshinari Nakatsuka; Toyohiro Hirai; Takateru Izumi

  Respiratory Investigation, Apr. 2022

  
• Sleep disordered breathing and haemoglobin A1c levels within or over normal range and ageing or sex differences: the Nagahama study.

  Takeshi Matsumoto; Kimihiko Murase; Yasuharu Tabara; Takuma Minami; Osamu Kanai; Hirofumi Takeyama; Hironobu Sunadome; Tadao Nagasaki; Naomi Takahashi; Yoshinari Nakatsuka; Satoshi Hamada; Tomohiro Handa; Kiminobu Tanizawa; Isuzu Nakamoto; Tomoko Wakamura; Naoko Komenami; Kazuya Setoh; Takahisa Kawaguchi; Takanobu Tsutsumi; Satoshi Morita; Yoshimitsu Takahashi; Takeo Nakayama; Susumu Sato; Toyohiro Hirai; Fumihiko Matsuda; Kazuo Chin

  Journal of sleep research, 27 Nov. 2022

  
• 両側肺門部リンパ節腫大が先行し、経過中に石灰化と肺多発結節影が出現した肺癌と悪性リンパ腫の合併症例

  曽根 尚之; 糸谷 涼; 池尾 聡; 嶋村 亜紀; 橋本 健太郎; 吉田 寛; 吉田 博徳; 阪森 優一; 平井 豊博

  気管支学, May 2022

  
• 難治性疾患克服を目指した次世代の治療ターゲット研究 ヒトiPS細胞を用いた呼吸器上皮細胞への分化誘導技術と細胞ファイバ技術を融合した新たな培養メソッドで切り開く肺再生研究の未来

  池尾 聡; 山本 佑樹; 池田 和弘; 曽根 尚之; 興梠 陽平; 平井 豊博; 後藤 慎平

  日本呼吸器学会誌, Apr. 2022

  
• 間質性肺疾患患者に対する胸部固定帯の鎮咳効果を評価した前後比較試験 胃食道逆流との関連

  佐藤 隆平; 半田 知宏; 松本 久子; 大倉 徳幸; 平井 豊博

  日本呼吸ケア・リハビリテーション学会誌, Oct. 2021

  
• Physiological impacts of computed tomography airway dysanapsis, fractal dimension and branch count in asymptomatic never smokers.

  Tomoki Maetani; Naoya Tanabe; Satoru Terada; Yusuke Shiraishi; Hiroshi Shima; Shizuo Kaji; Ryo Sakamoto; Tsuyoshi Oguma; Susumu Sato; Izuru Masuda; Toyohiro Hirai

  Journal of applied physiology (Bethesda, Md. : 1985), 21 Oct. 2022

  
• YAP1 mediates initial cell survival during lorlatinib treatment via AKT signaling in ROS1 ‐rearranged lung cancer

  Masatoshi Yamazoe; Hiroaki Ozasa; Takahiro Tsuji; Tomoko Funazo; Hiroshi Yoshida; Kentaro Hashimoto; Kazutaka Hosoya; Tatsuya Ogimoto; Hitomi Ajimizu; Hironori Yoshida; Ryo Itotani; Yuichi Sakamori; Kiyomitsu Kuninaga; Wataru Aoki; Toyohiro Hirai

  Cancer Science, 26 Oct. 2022

  
• Sarcomatoid malignant pleural mesothelioma treated with nivolumab: A case series

  Kentaro Hashimoto; Hiroaki Ozasa; Akihiko Yoshizawa; Hiroshi Yoshida; Tatsuya Ogimoto; Kazutaka Hosoya; Masatoshi Yamazoe; Hitomi Ajimizu; Tomoko Funazo; Hironori Yoshida; Yuichi Sakamori; Toyohiro Hirai

  Oncology Letters, 22 Sep. 2022

  
• Protein C activity as a potential prognostic factor for nursing home-acquired pneumonia

  Issei Oi; Isao Ito; Naoya Tanabe; Satoshi Konishi; Nobuyoshi Hamao; Masahiro Shirata; Seiichiro Imai; Yoshiro Yasutomo; Seizo Kadowaki; Hisako Matsumoto; Yu Hidaka; Satoshi Morita; Toyohiro Hirai

  PLOS ONE, 12 Oct. 2022

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• Clinical relevance of multiple confirmed preserved ratio impaired spirometry cases in adults.

  Naoya Tanabe; Izuru Masuda; Yusuke Shiraishi; Tomoki Maetani; Satoshi Hamada; Atsuyasu Sato; Susumu Sato; Toyohiro Hirai

  Respiratory investigation, 19 Sep. 2022

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• Lung fibrogenic microenvironment in mouse reconstitutes human alveolar structure and lung tumor.

  Ryo Miyata; Koichi Hasegawa; Toshi Menju; Akihiko Yoshizawa; Akira Watanabe; Toyohiro Hirai; Hiroshi Date; Atsuyasu Sato

  iScience, 16 Sep. 2022

  
• Multimodal telemonitoring for weight reduction in sleep apnea patients: A randomized controlled trial.

  Kimihiko Murase; Takuma Minami; Satoshi Hamada; David Gozal; Naomi Takahashi; Yoshinari Nakatsuka; Hirofumi Takeyama; Kiminobu Tanizawa; Daisuke Endo; Toshiki Akahoshi; Yasutaka Moritsuchi; Toru Tsuda; Yoshiro Toyama; Motoharu Ohi; Yasuhiro Tomita; Koji Narui; Naho Matsuyama; Tetsuro Ohdaira; Takatoshi Kasai; Tomomasa Tsuboi; Yasuhiro Gon; Yoshihiro Yamashiro; Shinichi Ando; Hiroyuki Yoshimine; Yoshifumi Takata; Akiomi Yoshihisa; Koichiro Tatsumi; Shin-Ichi Momomura; Tomohiro Kuroda; Satoshi Morita; Takeo Nakayama; Toyohiro Hirai; Kazuo Chin

  Chest, 20 Aug. 2022

  
• COVID19による呼吸不全によりECMO管理下に抗HIV療法を継続した症例

  和田 典也; 松村 勝之; 津田 真弘; 尾崎 淳子; 助石 有沙美; 白川 康太郎; 米澤 淳; 甲斐 慎一; 田辺 直也; 伊藤 功朗; 平井 豊博; 高折 晃史

  日本エイズ学会誌, Nov. 2021

  
• 新たな画像解析による呼吸機能の評価 健常人における気道・肺の形態の男女差の解析

  寺田 悟; 田辺 直也; 前谷 知毅; 白石 祐介; 張 怡; 島 寛; 小熊 毅; 佐藤 晋; 佐藤 篤靖; 桝田 出; 平井 豊博

  日本呼吸器学会誌, Apr. 2022

  
• 非COPD現喫煙者における肺気腫サブタイプと胸部CTで評価した肺外併存症の関連

  前谷 知毅; 田辺 直也; 寺田 悟; 白石 祐介; 張 怡; 島 寛; 小熊 毅; 佐藤 晋; 佐藤 篤靖; 桝田 出; 平井 豊博

  日本呼吸器学会誌, Apr. 2022

  
• COPD患者の機械学習を用いた胸部CTにおける傍壁在性肺気腫の定量化と臨床指標の関連

  張 怡; 田辺 直也; 鍛冶 静雄; 島 寛; 白石 祐介; 小熊 毅; 佐藤 篤靖; 佐藤 晋; 平井 豊博

  日本呼吸器学会誌, Apr. 2021

  
• COPD・ACO・喘息例における喀痰細菌叢の検討

  森本 千絵; 松本 久子; 小熊 毅; 佐藤 晋; 田辺 直也; 佐藤 篤靖; 古郷 摩利子; 野村 奈都子; 田嶋 範之; 砂留 広伸; 平井 豊博; 富井 啓介; 田尻 智子; 西村 尚志; 北 英夫; 月野 光博; 上田 哲也

  日本呼吸器学会誌, Apr. 2021

  
• COPD患者における,気腫・非気腫領域別の呼吸による体積変化率の分布一致度と呼吸機能との関連

  島 寛; 田辺 直也; 張 怡; 白石 祐介; 小澤 聡; 小熊 毅; 佐藤 篤靖; 鍛冶 静雄; 清水 薫子; 牧田 比呂仁; 西村 正治; 佐藤 晋; 今野 哲; 平井 豊博

  日本呼吸器学会誌, Apr. 2021

  
• Differences between subjective and objective sleep duration according to actual sleep duration and sleep-disordered breathing: the Nagahama Study.

  Naomi Takahashi; Takeshi Matsumoto; Yoshinari Nakatsuka; Kimihiko Murase; Yasuharu Tabara; Hirofumi Takeyama; Takuma Minami; Satoshi Hamada; Osamu Kanai; Kiminobu Tanizawa; Isuzu Nakamoto; Takahisa Kawaguchi; Kazuya Setoh; Takanobu Tsutsumi; Yoshimitsu Takahashi; Tomohiro Handa; Tomoko Wakamura; Naoko Komenami; Satoshi Morita; Toyohiro Hirai; Fumihiko Matsuda; Takeo Nakayama; Kazuo Chin

  Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 01 Mar. 2022

  
• Non-invasive ventilation using a novel ventilator and non-vented full-face mask for patients with respiratory failure during the COVID-19 pandemic: Report of three cases.

  Takuma Minami; Shinichi Kai; Tomoharu Tanaka; Isao Ito; Genta Kato; Miki Nagao; Hiroshi Date; Toyohiro Hirai; Shigeru Ohtsuru; Kazuo Chin

  Respiratory investigation, Jul. 2022

  
• Exacerbation of ventricular arrhythmias by continuous positive airway pressure treatment in idiopathic dilated cardiomyopathy.

  Satoshi Hamada; Anna Yoshino; Jumpei Togawa; Hironobu Sunadome; Tadao Nagasaki; Kazuyuki Ueda; Takeru Makiyama; Tomohiro Handa; Toyohiro Hirai; Susumu Sato

  Respiratory investigation, 12 Jul. 2022

  
• Quantitative computed tomography-based evaluation of skeletal muscle and presence of sarcopenia in patients with chronic obstructive pulmonary disease.

  Susumu Sato; Shigeo Muro; Tomoki Aoyama; Toyohiro Hirai

  Respiratory investigation, 26 May 2022

  
• 難治性疾患克服を目指した次世代の治療ターゲット研究 ヒトiPS細胞を用いた呼吸器上皮細胞への分化誘導技術と細胞ファイバ技術を融合した新たな培養メソッドで切り開く肺再生研究の未来

  池尾 聡; 山本 佑樹; 池田 和弘; 曽根 尚之; 興梠 陽平; 平井 豊博; 後藤 慎平

  日本呼吸器学会誌, Apr. 2022

  
• Perspectives of future lung toxicology studies using human pluripotent stem cells

  Atsushi Masui; Toyohiro Hirai; Shimpei Gotoh

  Archives of Toxicology, Feb. 2022

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• Usefulness of pro-gastrin-releasing peptide as a predictor of the incidence of brain metastasis and effect of prophylactic cranial irradiation in patients with limited-stage small-cell lung cancer.

  Kazuihto Ueki; Yukinori Matsuo; Noriko Kishi; Masahiro Yoneyama; Hironori Yoshida; Yuichi Sakamori; Hiroaki Ozasa; Toyohiro Hirai; Takashi Mizowaki

  Journal of radiation research, 02 Jul. 2022

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• Subtyping emphysematous COPD by respiratory volume change distributions on CT.

  Hiroshi Shima; Naoya Tanabe; Akira Oguma; Kaoruko Shimizu; Shizuo Kaji; Kunihiko Terada; Tsuyoshi Oguma; Takeshi Kubo; Masaru Suzuki; Hironi Makita; Atsuyasu Sato; Masaharu Nishimura; Susumu Sato; Satoshi Konno; Toyohiro Hirai

  Thorax, 29 Jun. 2022

  
• Non-respiratory symptom dominance is associated with depression in patients with chronic obstructive pulmonary disease.

  Yoko Hamakawa; Susumu Sato; Naoya Tanabe; Chin Kook Rhee; Ki-Suck Jung; Kwang Ha Yoo; Kazuya Tanimura; Shigeo Muro; Toyohiro Hirai

  Respiratory medicine, 31 May 2022

  
• The prevalence and physiological impacts of centrilobular and paraseptal emphysema on computed tomography in smokers with preserved ratio impaired spirometry.

  Yusuke Shiraishi; Takafumi Shimada; Naoya Tanabe; Kunihiko Terada; Ryo Sakamoto; Tomoki Maetani; Hiroshi Shima; Fumi Mochizuki; Tsuyoshi Oguma; Kaoruko Shimizu; Susumu Sato; Shigeo Muro; Nobuyuki Hizawa; Motonari Fukui; Hiroaki Iijima; Izuru Masuda; Toyohiro Hirai

  ERJ open research, Apr. 2022

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• Evaluation of respiratory rate monitoring performance using a home oxygen monitoring device among patients with interstitial lung disease and chronic obstructive pulmonary disease.

  Satoshi Hamada; Tomohiro Handa; Naoya Tanabe; Susumu Sato; Kiminobu Tanizawa; Atsuyasu Sato; Satoshi Morita; Kazuo Chin; Toyohiro Hirai

  Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG, 2022

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• Is High-Flow Nasal Cannula Oxygen Therapy an Aerosol-Generating Medical Procedure?

  Satoshi Hamada; Naoya Tanabe; Hideki Inoue; Toyohiro Hirai

  Archivos de bronconeumologia, Sep. 2021

  
• COVID-19肺炎の臨床像 多施設共同研究から見えてきたもの

  伊藤 功朗; 石田 直; 伊藤 明広; 遠藤 和夫; 平林 正孝; 江村 正仁; 山本 舜悟; 小嶋 徹; 塚尾 仁一; 富井 啓介; 中川 淳; 大塚 浩二郎; 赤井 雅也; 大井 昌寛; 杉田 孝和; 福井 基成; 井上 大生; 長谷川 吉則; 高橋 憲一; 安井 浩明; 藤田 浩平; 北 英夫; 加持 雄介; 土谷 美知子; 冨岡 洋海; 山田 孝; 寺田 悟; 中治 仁志; 西村 尚志; 大井 一成; 濱尾 信叔; 白田 全弘; 西岡 憲亮; 林 康之; 山添 正敏; 白石 祐介; 大木元 達也; 細谷 和貴; 味水 瞳; 島 寛; 長谷川 浩一; 田辺 直也; 平井 豊博

  日本化学療法学会雑誌, Mar. 2022

  
• 呼吸不全を伴わない新型コロナウイルス肺炎とマイコプラズマ肺炎の臨床像の比較

  白田 全弘; 伊藤 功朗; 石田 直; 伊藤 明広; 山本 舜悟; 富井 啓介; 中川 淳; 小嶋 徹; 大塚 浩二郎; 杉田 孝和; 安井 浩明; 長谷川 吉則; 藤田 浩平; 北 英夫; 土谷 美知子; 冨岡 洋海; 福井 基成; 井上 大生; 加持 雄介; 平井 豊博; 関西COVID-19研究チーム

  感染症学雑誌, Apr. 2021

  
• 65歳以上のCOVID-19肺炎患者における肺野自動解析を用いた画像所見の定量的検討

  濱尾 信叔; 伊藤 功朗; 山本 舜悟; 長谷川 吉則; 山添 正敏; 大井 一成; 白田 全弘; 西岡 憲亮; 平井 豊博

  感染症学雑誌, Apr. 2021

  
• 新型コロナウイルス肺炎とインフルエンザ肺炎の臨床像の比較 ROC解析を用いて

  大井 一成; 伊藤 功朗; 山本 舜悟; 小嶋 徹; 富井 啓介; 中川 淳; 大塚 浩二郎; 杉田 孝和; 福井 基成; 井上 大生; 長谷川 吉則; 安井 浩明; 藤田 浩平; 石田 直; 伊藤 明広; 北 英夫; 加持 雄介; 土谷 美知子; 冨岡 洋海; 平井 豊博; 関西COVID-19研究チーム

  感染症学雑誌, Apr. 2021

  
• 新型コロナウイルス肺炎とインフルエンザウイルス肺炎の予後因子についての検討 ROC解析を用いて

  伊藤 功朗; 大井 一成; 山本 舜悟; 小嶋 徹; 富井 啓介; 中川 淳; 大塚 浩二郎; 杉田 孝和; 福井 基成; 井上 大生; 長谷川 吉則; 安井 浩明; 藤田 浩平; 石田 直; 伊藤 明広; 北 英夫; 加持 雄介; 土谷 美知子; 冨岡 洋海; 平井 豊博; 関西COVID-19研究チーム

  感染症学雑誌, Apr. 2021

  
• Associations of pulmonary and extrapulmonary computed tomographic manifestations with impaired physical activity in symptomatic patients with chronic obstructive pulmonary disease.

  Yoko Hamakawa; Naoya Tanabe; Hiroshi Shima; Kunihiko Terada; Yusuke Shiraishi; Tomoki Maetani; Takeshi Kubo; Satoshi Kozawa; Koji Koizumi; Masashi Kanezaki; Kaoruko Shimizu; Tsuyoshi Oguma; Atsuyasu Sato; Susumu Sato; Toyohiro Hirai

  Scientific reports, 04 Apr. 2022

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• Air Collection in the Intrathoracic Extrapleural Space-like Pneumothorax.

  Satoshi Hamada; Naoya Tanabe; Toyohiro Hirai

  Internal medicine (Tokyo, Japan), 02 Apr. 2022

  
• Further evidence for association of YKL-40 with severe asthma airway remodeling

  Hirokazu Kimura; Kaoruko Shimizu; Naoya Tanabe; Hironi Makita; Natsuko Taniguchi; Hiroki Kimura; Masaru Suzuki; Yuki Abe; Machiko Matsumoto-Sasaki; Akira Oguma; Michiko Takimoto-Sato; Nozomu Takei; Munehiro Matsumoto; Houman Goudarzi; Susumu Sato; Junya Ono; Kenji Izuhara; Toyohiro Hirai; Masaharu Nishimura; Satoshi Konno

  Annals of Allergy, Asthma & Immunology, Mar. 2022

  
• Clinical, radiological and pathological features of idiopathic and secondary interstitial pneumonia with pleuroparenchymal fibroelastosis in patients undergoing lung transplantation.

  Naoya Ikegami; Naoki Nakajima; Akihiko Yoshizawa; Tomohiro Handa; Toyofumi Chen-Yoshikawa; Takeshi Kubo; Kiminobu Tanizawa; Akihiro Ohsumi; Yoshito Yamada; Masatsugu Hamaji; Daisuke Nakajima; Yojiro Yutaka; Satona Tanaka; Kizuku Watanabe; Yoshinari Nakatsuka; Yuko Murase; Tomoko Nakanishi; Takafumi Niwamoto; Kazuo Chin; Hiroshi Date; Toyohiro Hirai

  Histopathology, Mar. 2022

  
• Physiological Impairments on Respiratory Oscillometry and Future Exacerbations in Chronic Obstructive Pulmonary Disease Patients without a History of Frequent Exacerbations.

  Yi Zhang; Naoya Tanabe; Hiroshi Shima; Yusuke Shiraisi; Tsuyoshi Oguma; Atsuyasu Sato; Shigeo Muro; Susumu Sato; Toyohiro Hirai

  COPD, 2022

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• 慢性副鼻腔炎/好酸球性副鼻腔炎の粘液CT値および物性に関する検討

  宮部 結; 田辺 直也; 進藤 允; 島 寛; 谷村 和哉; 松脇 由典; 福地 峰世; 嵯峨 知生; 山田 武千代; 平井 豊博; 植木 重治

  アレルギー, Aug. 2021

  
• 気管支喘息(成人) 管理:合併症,COVID-19 中高年発症喘息と睡眠呼吸障害の関係 ながはまスタディ

  砂留 広伸; 松本 久子; 村瀬 公彦; 田原 康玄; 西 健太; 寺田 悟; 野村 奈都子; 古郷 摩利子; 田嶋 範之; 森本 千絵; 高橋 順美; 松本 健; 濱田 哲; 長崎 忠雄; 小熊 毅; 谷澤 公伸; 半田 知宏; 佐藤 晋; 森田 智視; 平井 豊博; 松田 文彦; 陳 和夫

  アレルギー, Aug. 2021

  
• COPD患者の予後改善は成ったか? 2つのCOPDコホート研究より

  佐藤 晋; 小賀 徹; 室 繁郎; 谷村 和哉; 田辺 直也; 西村 浩一; 平井 豊博

  日本呼吸器学会誌, Apr. 2021

  
• 睡眠呼吸障害のバイオマーカーとしての血清尿酸値の有用性の検討 ながはまスタディ

  砂留 広伸; 村瀬 公彦; 田原 康玄; 南 卓馬; 武山 博文; 高橋 順美; 松本 健; 濱田 哲; 長崎 忠雄; 谷澤 公伸; 半田 知宏; 松本 久子; 若村 智子; 森田 智視; 平井 豊博; 松田 文彦; 陳 和夫

  日本呼吸器学会誌, Apr. 2021

  
• 喫煙者における末梢血好酸球数と末梢気道好酸球炎症の関連

  進藤 允; 田辺 直也; 佐藤 篤靖; 小川 惠美子; 室 繁郎; 伊達 洋至; 佐藤 晋; 松本 久子; 平井 豊博

  日本呼吸器学会誌, Apr. 2021

  
• 病診薬連携で行う吸入支援のアウトカムの評価

  鋒山 香苗; 杉本 充弘; 米澤 淳; 寺尾 真琴; 山本 浩貴; 吉田 優子; 朝倉 佳代子; 深津 祥央; 谷村 和哉; 佐藤 晋; 松本 久子; 中川 俊作; 北田 徳昭; 平井 豊博; 松原 和夫

  医療薬学, Aug. 2020

  
• 慢性喫煙による末梢気道線毛上皮細胞傷害からの再生に及ぼすプロテアーゼ活性についての検討

  上桝 潔; 佐藤 篤靖; 田辺 直也; 長谷川 浩一; 谷村 和哉; 濱川 瑶子; 水谷 達志; 佐藤 晋; 平井 豊博

  日本呼吸器学会誌, Mar. 2019

  
• 小動物用CT画像を用いた微小肺気腫病変のクラスター解析

  伏屋 芳紀; 佐藤 篤靖; 佐藤 晋; 谷村 和哉; 長谷川 浩一; 上桝 潔; 濱川 瑶子; 酒井 直樹; 室 繁郎; 平井 豊博

  日本呼吸器学会誌, Mar. 2017

  
• エラスターゼ傷害肺気腫マウスにおける呼吸インピーダンスと胸部CT画像解析による機能的・構造的不均一性の評価

  佐藤 晋; 佐藤 篤靖; 伏屋 芳紀; 谷村 和哉; 長谷川 浩一; 上桝 潔; 濱川 瑶子; 室 繁郎; 平井 豊博

  日本呼吸器学会誌, Mar. 2017

  
• Deep learning-based reconstruction of chest ultra-high-resolution computed tomography and quantitative evaluations of smaller airways.

  Naoya Tanabe; Ryo Sakamoto; Satoshi Kozawa; Tsuyoshi Oguma; Hiroshi Shima; Yusuke Shiraishi; Koji Koizumi; Susumu Sato; Yuji Nakamoto; Toyohiro Hirai

  Respiratory investigation, Jan. 2022

  
• Population pharmacokinetic modeling of GS-441524, the active metabolite of remdesivir, in Japanese COVID-19 patients with renal dysfunction.

  Asami Sukeishi; Kotaro Itohara; Atsushi Yonezawa; Yuki Sato; Katsuyuki Matsumura; Yoshiki Katada; Takayuki Nakagawa; Satoshi Hamada; Naoya Tanabe; Eishi Imoto; Shinichi Kai; Toyohiro Hirai; Motoko Yanagita; Shigeru Ohtsuru; Tomohiro Terada; Isao Ito

  CPT: pharmacometrics & systems pharmacology, Jan. 2022

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• Development and validation of a new scoring system for prognostic prediction of community-acquired pneumonia in older adults.

  Masahiro Shirata; Isao Ito; Tadashi Ishida; Hiromasa Tachibana; Naoya Tanabe; Satoshi Konishi; Issei Oi; Nobuyoshi Hamao; Kensuke Nishioka; Hisako Matsumoto; Yoshiro Yasutomo; Seizo Kadowaki; Hisashi Ohnishi; Hiromi Tomioka; Takashi Nishimura; Yoshinori Hasegawa; Atsushi Nakagawa; Toyohiro Hirai

  Scientific reports, 13 Dec. 2021

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• Survival impact of treatment for chronic obstructive pulmonary disease in patients with advanced non-small-cell lung cancer

  Hitomi Ajimizu; Hiroaki Ozasa; Susumu Sato; Tomoko Funazo; Yuichi Sakamori; Takashi Nomizo; Kiyomitsu Kuninaga; Tatsuya Ogimoto; Kazutaka Hosoya; Masatoshi Yamazoe; Takahiro Tsuji; Hironori Yoshida; Ryo Itotani; Kentaro Ueno; Young Hak Kim; Shigeo Muro; Toyohiro Hirai

  Scientific Reports, Dec. 2021

  
• Recent advances in airway imaging using micro-computed tomography and computed tomography for chronic obstructive pulmonary disease.

  Naoya Tanabe; Toyohiro Hirai

  The Korean journal of internal medicine, Nov. 2021

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• 睡眠時呼吸障害のバイオマーカーとしての血清尿酸値の有用性の検討 ながはまスタディ

  砂留 広伸; 村瀬 公彦; 田原 康玄; 高橋 順美; 松本 健; 濱田 哲; 長崎 忠雄; 谷澤 公伸; 半田 知宏; 松本 久子; 若村 智子; 森田 智視; 平井 豊博; 松田 文彦; 陳 和夫

  日本睡眠学会定期学術集会プログラム・抄録集, Sep. 2021

  
• 主観的、客観的睡眠時間の差と睡眠呼吸障害、非回復性睡眠の関連 ながはまスタディ

  高橋 順美; 松本 健; 中塚 賀也; 村瀬 公彦; 田原 康玄; 武山 博文; 川口 喬久; 瀬藤 和也; 堤 孝信; 高橋 由光; 若村 智子; 松田 文彦; 平井 豊博; 中山 健夫; 陳 和夫

  日本睡眠学会定期学術集会プログラム・抄録集, Sep. 2021

  
• 検査法 ながはまコホート研究における気流閉塞,呼吸困難の発症リスク因子

  古郷 摩利子; 佐藤 晋; 室 繁郎; 松本 久子; 野村 奈都子; 田嶋 範之; 砂留 広伸; 長崎 忠雄; 村瀬 公彦; 川口 喬久; 田原 康玄; 松田 文彦; 陳 和夫; 平井 豊博

  アレルギー, Aug. 2021

  
• 喘息関連疾患・病態 閉塞性気道疾患における黄色ブドウ球菌エンテロトキシン(SE)感作と喀痰細菌叢の検討

  森本 千絵; 松本 久子; 小熊 毅; 佐藤 晋; 田辺 直也; 佐藤 篤靖; 古郷 摩利子; 野村 奈都子; 田嶋 範之; 砂留 広伸; 富井 啓介; 田尻 智子; 西村 尚志; 北 英夫; 月野 光博; 上田 哲也; 塚原 隆充; 平井 豊博

  アレルギー, Aug. 2021

  
• Cutaneous T-cell-attracting chemokine as a novel biomarker for predicting prognosis of idiopathic pulmonary fibrosis: a prospective observational study.

  Takafumi Niwamoto; Tomohiro Handa; Yuko Murase; Yoshinari Nakatsuka; Kiminobu Tanizawa; Yoshio Taguchi; Hiromi Tomioka; Keisuke Tomii; Hideo Kita; Michihiro Uyama; Michiko Tsuchiya; Masahito Emura; Tetsuji Kawamura; Naoki Arai; Machiko Arita; Kazuko Uno; Akihiko Yoshizawa; Ryuji Uozumi; Izumi Yamaguchi; Fumihiko Matsuda; Kazuo Chin; Toyohiro Hirai

  Respiratory research, 17 Jun. 2021

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• 睡眠呼吸障害とHbA1c値及び糖尿病治療の有無との関連 ながはまスタディ

  松本 健; 村瀬 公彦; 田原 康玄; 南 卓馬; 谷澤 公伸; 若村 智子; 平井 豊博; 松田 文彦; 陳 和夫

  日本呼吸器学会誌, Apr. 2021

  
• 睡眠時無呼吸患者に対する遠隔モニタリングシステムを利用した体重減量指導の効果 多施設共同無作為化比較試験

  村瀬 公彦; 陳 和夫; 赤星 俊樹; 津田 徹; 大井 元晴; 外山 善朗; 成井 浩司; 富田 康弘; 大平 徹郎; 葛西 隆敏; 坪井 知正; 權 寧博; 山城 義広; 安藤 眞一; 吉嶺 裕之; 高田 佳史; 義久 精臣; 巽 浩一郎; 百村 伸一; 森田 智視; 黒田 知宏; 平井 豊博; 厚生労働科学研究遠隔モニタリング研究班

  日本呼吸器学会誌, Apr. 2021

  
• Kernel Conversion for Robust Quantitative Measurements of Archived Chest Computed Tomography Using Deep Learning-Based Image-to-Image Translation.

  Naoya Tanabe; Shizuo Kaji; Hiroshi Shima; Yusuke Shiraishi; Tomoki Maetani; Tsuyoshi Oguma; Susumu Sato; Toyohiro Hirai

  Frontiers in artificial intelligence, 2021

  
• Annual Body Weight Change and Prognosis in Chronic Obstructive Pulmonary Disease.

  Yuki Abe; Masaru Suzuki; Hiroshi Shima; Yusuke Shiraishi; Naoya Tanabe; Susumu Sato; Kaoruko Shimizu; Hirokazu Kimura; Hironi Makita; Toyohiro Hirai; Satoshi Konno; Masaharu Nishimura

  International journal of chronic obstructive pulmonary disease, 2021

  
• Antitussive Effect of a Chest Band in Patients with Interstitial Lung Disease: The Preliminary Results from a Pre-post Intervention Study

  Ryuhei Sato; Tomohiro Handa; Hisako Matsumoto; Kota Hirai; Noriyuki Ohkura; Takeshi Kubo; Toyohiro Hirai

  Internal Medicine, 01 Dec. 2021

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• Modeling of lung phenotype of Hermansky–Pudlak syndrome type I using patient-specific iPSCs

  Takahiro Suezawa; Shuhei Kanagaki; Yohei Korogi; Kazuhisa Nakao; Toyohiro Hirai; Koji Murakami; Masatoshi Hagiwara; Shimpei Gotoh

  Respiratory Research, Dec. 2021

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• The importance of central airway dilatation in patients with bronchiolitis obliterans.

  Mariko Kogo; Hisako Matsumoto; Naoya Tanabe; Toyofumi F Chen-Yoshikawa; Naoki Nakajima; Akihiko Yoshizawa; Tsuyoshi Oguma; Susumu Sato; Natsuko Nomura; Chie Morimoto; Hironobu Sunadome; Shimpei Gotoh; Akihiro Ohsumi; Hiroshi Date; Toyohiro Hirai

  ERJ open research, Oct. 2021

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• 睡眠障害診断の新しい進歩 呼吸音解析とミリ波レーダ測定を用いた人体のバイタルモニタリング

  瀧 宏文; 奥村 成皓; 沖中 宏彰; 阪本 卓也; 砂留 広伸; 長崎 忠雄; 佐藤 晋; 平井 豊博; 陳 和夫

  日本睡眠学会定期学術集会プログラム・抄録集, Sep. 2021

  
• 保険医療下の睡眠医学の新しい流れ 経皮PCO2の保険医療の拡大の必要性について

  上田 和幸; 長崎 忠雄; 砂留 広伸; 十川 純平; 濱田 哲; 石川 裕子; 増田 優里; 今井 理恵; 吉野 杏菜; 横溝 綾香; 佐藤 晋; 平井 豊博; 陳 和夫

  日本睡眠学会定期学術集会プログラム・抄録集, Sep. 2021

  
• ミリ波レーダを用いた呼吸・心拍非接触測定による継続的モニタリング技術

  瀧 宏文; 奥村 成皓; 沖中 宏彰; 森本 和志; 三谷 壮平; 香田 隆斗; 阪本 卓也; 砂留 広伸; 長崎 忠雄; 佐藤 晋; 平井 豊博; 陳 和夫

  日本睡眠学会定期学術集会プログラム・抄録集, Sep. 2021

  
• 慢性副鼻腔炎/好酸球性副鼻腔炎の粘液CT値および物性に関する検討

  宮部 結; 田辺 直也; 進藤 允; 島 寛; 谷村 和哉; 松脇 由典; 福地 峰世; 嵯峨 知生; 山田 武千代; 平井 豊博; 植木 重治

  アレルギー, Aug. 2021

  
• 検査法 ながはまコホート研究における気流閉塞,呼吸困難の発症リスク因子

  古郷 摩利子; 佐藤 晋; 室 繁郎; 松本 久子; 野村 奈都子; 田嶋 範之; 砂留 広伸; 長崎 忠雄; 村瀬 公彦; 川口 喬久; 田原 康玄; 松田 文彦; 陳 和夫; 平井 豊博

  アレルギー, Aug. 2021

  
• 気管支喘息(成人) 管理:合併症,COVID-19 中高年発症喘息と睡眠呼吸障害の関係 ながはまスタディ

  砂留 広伸; 松本 久子; 村瀬 公彦; 田原 康玄; 西 健太; 寺田 悟; 野村 奈都子; 古郷 摩利子; 田嶋 範之; 森本 千絵; 高橋 順美; 松本 健; 濱田 哲; 長崎 忠雄; 小熊 毅; 谷澤 公伸; 半田 知宏; 佐藤 晋; 森田 智視; 平井 豊博; 松田 文彦; 陳 和夫

  アレルギー, Aug. 2021

  
• 喘息関連疾患・病態 閉塞性気道疾患における黄色ブドウ球菌エンテロトキシン(SE)感作と喀痰細菌叢の検討

  森本 千絵; 松本 久子; 小熊 毅; 佐藤 晋; 田辺 直也; 佐藤 篤靖; 古郷 摩利子; 野村 奈都子; 田嶋 範之; 砂留 広伸; 富井 啓介; 田尻 智子; 西村 尚志; 北 英夫; 月野 光博; 上田 哲也; 塚原 隆充; 平井 豊博

  アレルギー, Aug. 2021

  
• 喫煙者における末梢血好酸球数と末梢気道好酸球炎症の関連

  進藤 允; 田辺 直也; 佐藤 篤靖; 小川 惠美子; 室 繁郎; 伊達 洋至; 佐藤 晋; 松本 久子; 平井 豊博

  日本呼吸器学会誌, Apr. 2021

  
• COPD合併進行非小細胞肺癌患者へのCOPD薬物治療の意義(2nd Report)

  國永 清光; 小笹 裕晃; 味水 瞳; 阪森 優一; 吉田 博徳; 糸谷 涼; 野溝 岳; 金 永学; 佐藤 晋; 平井 豊博

  日本呼吸器学会誌, Apr. 2021

  
• 日本人の肺気腫サブタイプ別の頻度と臨床的意義に関する検討 多施設共同研究

  白石 祐介; 小熊 昂; 嶋田 貴文; 田辺 直也; 寺田 邦彦; 清水 薫子; 望月 芙美; 飯島 弘晃; 室 繁郎; 牧田 比呂仁; 西村 正治; 佐藤 晋; 今野 哲; 平井 豊博

  日本呼吸器学会誌, Apr. 2021

  
• COPD患者の予後改善は成ったか? 2つのCOPDコホート研究より

  佐藤 晋; 小賀 徹; 室 繁郎; 谷村 和哉; 田辺 直也; 西村 浩一; 平井 豊博

  日本呼吸器学会誌, Apr. 2021

  
• 閉塞性細気管支炎における気管支拡張の意義について

  古郷 摩利子; 松本 久子; 田辺 直也; 芳川 豊史; 中島 直樹; 吉澤 明彦; 小熊 毅; 佐藤 晋; 野村 奈都子; 森本 千絵; 砂留 広伸; 後藤 慎平; 大角 明宏; 伊達 洋至; 平井 豊博

  日本呼吸器学会誌, Apr. 2021

  
• COPD患者の機械学習を用いた胸部CTにおける傍壁在性肺気腫の定量化と臨床指標の関連

  張 怡; 田辺 直也; 鍛冶 静雄; 島 寛; 白石 祐介; 小熊 毅; 佐藤 篤靖; 佐藤 晋; 平井 豊博

  日本呼吸器学会誌, Apr. 2021

  
• COPD・ACO・喘息例における喀痰細菌叢の検討

  森本 千絵; 松本 久子; 小熊 毅; 佐藤 晋; 田辺 直也; 佐藤 篤靖; 古郷 摩利子; 野村 奈都子; 田嶋 範之; 砂留 広伸; 平井 豊博; 富井 啓介; 田尻 智子; 西村 尚志; 北 英夫; 月野 光博; 上田 哲也

  日本呼吸器学会誌, Apr. 2021

  
• COPD患者における,気腫・非気腫領域別の呼吸による体積変化率の分布一致度と呼吸機能との関連

  島 寛; 田辺 直也; 張 怡; 白石 祐介; 小澤 聡; 小熊 毅; 佐藤 篤靖; 鍛冶 静雄; 清水 薫子; 牧田 比呂仁; 西村 正治; 佐藤 晋; 今野 哲; 平井 豊博

  日本呼吸器学会誌, Apr. 2021

  
• 慢性呼吸器疾患における呼吸検知センサーTeleOxの有用性の検討

  濱田 哲; 半田 知宏; 田辺 直也; 中塚 賀也; 谷澤 公伸; 佐藤 篤靖; 佐藤 晋; 陳 和夫; 平井 豊博

  日本呼吸ケア・リハビリテーション学会誌, Feb. 2021

  
• うつ病性障害併存COPD患者におけるCOPDアセスメントテスト

  濱川 瑤子; 佐藤 晋; 室 繁郎; 田辺 直也; 渡邊 アヤ; 島 寛; 谷村 和哉; 佐藤 篤靖; 福井 基成; 平井 豊博

  日本呼吸ケア・リハビリテーション学会誌, Feb. 2021

  
• 胸部CTで評価した脊柱起立筋横断面積、肺気腫病変、気道病変がCOPD患者の長期予後に与える影響

  田辺 直也; 佐藤 晋; 谷村 和哉; 佐藤 篤靖; 室 繁郎; 平井 豊博

  日本呼吸ケア・リハビリテーション学会誌, Feb. 2021

  
• Image diagnosis

  HIRAI Toyohiro

  Nihon Naika Gakkai Kaishi, 10 Jun. 2012

  
• Core-shell hydrogel microfiber-expanded pluripotent stem cell-derived lung progenitors applicable to lung reconstruction in vivo

  Satoshi Ikeo; Yuki Yamamoto; Kazuhiro Ikeda; Naoyuki Sone; Yohei Korogi; Lucia Tomiyama; Hisako Matsumoto; Toyohiro Hirai; Masatoshi Hagiwara; Shimpei Gotoh

  Biomaterials, Sep. 2021

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• Parenchymal destruction in asthma: Fixed airflow obstruction and lung function trajectory.

  Kaoruko Shimizu; Naoya Tanabe; Akira Oguma; Hirokazu Kimura; Masaru Suzuki; Isao Yokota; Hironi Makita; Susumu Sato; Toyohiro Hirai; Masaharu Nishimura; Satoshi Konno

  The Journal of allergy and clinical immunology, 24 Aug. 2021

  
• Novel Artificial Intelligence-based Technology for Chest Computed Tomography Analysis of Idiopathic Pulmonary Fibrosis.

  Tomohiro Handa; Kiminobu Tanizawa; Tsuyoshi Oguma; Ryuji Uozumi; Kizuku Watanabe; Naoya Tanabe; Takafumi Niwamoto; Hiroshi Shima; Ryobu Mori; Tomomi W Nobashi; Ryo Sakamoto; Takeshi Kubo; Atsuko Kurosaki; Kazuma Kishi; Yuji Nakamoto; Toyohiro Hirai

  Annals of the American Thoracic Society, 19 Aug. 2021

  
• Association of Sleep Disordered Breathing and Blood Pressure with Albuminuria: The Nagahama Study.

  Kimihiko Murase; Takeshi Matsumoto; Yasuharu Tabara; Adrienne Ohler; David Gozal; Takuma Minami; Osamu Kanai; Hirofumi Takeyama; Naomi Takahashi; Satoshi Hamada; Kiminobu Tanizawa; Tomoko Wakamura; Naoko Komenami; Kazuya Setoh; Takahisa Kawaguchi; Takanobu Tsutsumi; Satoshi Morita; Yoshimitsu Takahashi; Takeo Nakayama; Motoko Yanagita; Toyohiro Hirai; Fumihiko Matsuda; Kazuo Chin

  Annals of the American Thoracic Society, 04 Aug. 2021

  
• A homological approach to a mathematical definition of pulmonary fibrosis and emphysema on computed tomography.

  Naoya Tanabe; Shizuo Kaji; Susumu Sato; Tomoo Yokoyama; Tsuyoshi Oguma; Kiminobu Tanizawa; Tomohiro Handa; Takashi Sakajo; Toyohiro Hirai

  Journal of applied physiology (Bethesda, Md. : 1985), 01 Aug. 2021

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• Impacts of lipid-related metabolites, adiposity, and genetic background on blood eosinophil counts: the Nagahama study.

  Kenta Nishi; Hisako Matsumoto; Noriyuki Tashima; Satoru Terada; Natsuko Nomura; Mariko Kogo; Chie Morimoto; Hironobu Sunadome; Tadao Nagasaki; Tsuyoshi Oguma; Yoshinari Nakatsuka; Kimihiko Murase; Takahisa Kawaguchi; Yasuharu Tabara; Kazuhiro Sonomura; Fumihiko Matsuda; Kazuo Chin; Toyohiro Hirai

  Scientific reports, 28 Jul. 2021

  
• Multicellular modeling of ciliopathy by combining iPS cells and microfluidic airway-on-a-chip technology.

  Naoyuki Sone; Satoshi Konishi; Koichi Igura; Koji Tamai; Satoshi Ikeo; Yohei Korogi; Shuhei Kanagaki; Toshinori Namba; Yuki Yamamoto; Yifei Xu; Kazuhiko Takeuchi; Yuichi Adachi; Toyofumi F Chen-Yoshikawa; Hiroshi Date; Masatoshi Hagiwara; Sachiko Tsukita; Toyohiro Hirai; Yu-Suke Torisawa; Shimpei Gotoh

  Science translational medicine, 07 Jul. 2021

  
• Pneumonia Caused by Severe Acute Respiratory Syndrome Coronavirus 2 and Influenza Virus: A Multicenter Comparative Study.

  Issei Oi; Isao Ito; Masataka Hirabayashi; Kazuo Endo; Masahito Emura; Toru Kojima; Hitokazu Tsukao; Keisuke Tomii; Atsushi Nakagawa; Kojiro Otsuka; Masaya Akai; Masahiro Oi; Takakazu Sugita; Motonari Fukui; Daiki Inoue; Yoshinori Hasegawa; Kenichi Takahashi; Hiroaki Yasui; Kohei Fujita; Tadashi Ishida; Akihiro Ito; Hideo Kita; Yusuke Kaji; Michiko Tsuchiya; Hiromi Tomioka; Takashi Yamada; Satoru Terada; Hitoshi Nakaji; Nobuyoshi Hamao; Masahiro Shirata; Kensuke Nishioka; Masatoshi Yamazoe; Yusuke Shiraishi; Tatsuya Ogimoto; Kazutaka Hosoya; Hitomi Ajimizu; Hiroshi Shima; Hisako Matsumoto; Naoya Tanabe; Toyohiro Hirai

  Open forum infectious diseases, Jul. 2021

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• Reply to: What is "functional small airway disease" in inspiratory and expiratory CT images?

  Naoya Tanabe; Hiroshi Shima; Susumu Sato; Toyohiro Hirai

  Respiratory investigation, Jul. 2021

  
• Influence of Asthma Onset on Airway Dimensions on Ultra-high-resolution Computed Tomography in Chronic Obstructive Pulmonary Disease.

  Naoya Tanabe; Susumu Sato; Tsuyoshi Oguma; Hiroshi Shima; Takeshi Kubo; Satoshi Kozawa; Koji Koizumi; Atsuyasu Sato; Kaori Togashi; Hisako Matsumoto; Toyohiro Hirai

  Journal of thoracic imaging, 01 Jul. 2021

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• Expiratory central airway collapse and symptoms in smokers.

  Naoya Tanabe; Kunihiko Terada; Hiroshi Shima; Yoko Hamakawa; Yusuke Shiraishi; Kaoruko Shimizu; Atsuyasu Sato; Tsuyoshi Oguma; Susumu Sato; Toyohiro Hirai

  Respiratory investigation, Jul. 2021

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• Humidification via high-flow nasal cannula oxygen therapy does not generate aerosols.

  Satoshi Hamada; Naoya Tanabe; Toyohiro Hirai

  British journal of anaesthesia, 30 Jun. 2021

  
• Combined assessment of pulmonary arterial enlargement and coronary calcification predicts the prognosis of patients with chronic obstructive pulmonary disease.

  Nozomu Takei; Masaru Suzuki; Naoya Tanabe; Akira Oguma; Kaoruko Shimizu; Hirokazu Kimura; Hironi Makita; Susumu Sato; Toyohiro Hirai; Isao Yokota; Satoshi Konno; Masaharu Nishimura

  Respiratory medicine, 23 Jun. 2021

  
• Markers of cardiovascular disease risk in sleep-disordered breathing with or without comorbidities: the Nagahama Study

  Yoshinari Nakatsuka; Kimihiko Murase; Takeshi Matsumoto; Yasuharu Tabara; Isuzu Nakamoto; Takuma Minami; Naomi Takahashi; Hirofumi Takeyama; Osamu Kanai; Satoshi Hamada; Kiminobu Tanizawa; Tomohiro Handa; Tomoko Wakamura; Naoko Komenami; Satoshi Morita; Takeo Nakayama; Toyohiro Hirai; Fumihiko Matsuda; Kazuo Chin

  Journal of Clinical Sleep Medicine, 17 Jun. 2021

  
• Prospective associations of sleep apnea, periodic limb movements, and plasma fibrinogen level.

  Kimihiko Murase; Masanori Azuma; Ryo Tachikawa; Takuma Minami; Takeshi Matsumoto; Satoshi Hamada; Yoshinari Nakatsuka; Naomi Takahashi; Hirofumi Takeyama; Kiminobu Tanizawa; Toru Oga; Tomohiro Handa; Toyohiro Hirai; Kazuo Chin

  Sleep & breathing = Schlaf & Atmung, Jun. 2021

  
• Effects of combined oxygen and surgical masks on inspired fraction of oxygen: relevance to COVID-19-induced respiratory failure.

  Satoshi Hamada; Naoya Tanabe; Toyohiro Hirai

  British journal of anaesthesia, Jun. 2021

  
• Risk factors associated with methicillin-resistant Staphylococcus aureus isolation from serially collected sputum samples of patients hospitalized with pneumonia.

  Masahiro Shirata; Isao Ito; Naoya Tanabe; Satoshi Konishi; Issei Oi; Nobuyoshi Hamao; Hisako Matsumoto; Yoshiro Yasutomo; Seizo Kadowaki; Toyohiro Hirai

  Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 17 May 2021

  
• Speech Sounds and the Production of Droplets and Aerosols.

  Satoshi Hamada; Naoya Tanabe; Toyohiro Hirai

  Internal medicine (Tokyo, Japan), 15 May 2021

  
• 遷延性咳嗽における代謝物質の解析 ながはま0次予防コホート事業

  寺田 悟; 松本 久子; 田嶋 範之; 西 健太; 野村 奈都子; 古郷 摩利子; 森本 千絵; 砂留 広伸; 長崎 忠雄; 小熊 毅; 中塚 賀也; 村瀬 公彦; 川口 喬久; 田原 康玄; 園村 和弘; 松田 文彦; 陳 和夫; 平井 豊博

  日本呼吸器学会誌, Apr. 2021

  
• 末梢血好酸球数とβ-ヒドロキシ酪酸の関係 ながはま疫学研究

  西 健太; 松本 久子; 田嶋 範之; 寺田 悟; 野村 奈都子; 古郷 摩利子; 森本 千絵; 砂留 広伸; 長崎 忠雄; 小熊 毅; 中塚 賀也; 村瀬 公彦; 川口 喬久; 田原 康玄; 園村 和弘; 松田 文彦; 陳 和夫; 平井 豊博

  日本呼吸器学会誌, Apr. 2021

  
• 睡眠呼吸障害とHbA1c値及び糖尿病治療の有無との関連 ながはまスタディ

  松本 健; 村瀬 公彦; 田原 康玄; 南 卓馬; 谷澤 公伸; 若村 智子; 平井 豊博; 松田 文彦; 陳 和夫

  日本呼吸器学会誌, Apr. 2021

  
• 睡眠呼吸障害のバイオマーカーとしての血清尿酸値の有用性の検討 ながはまスタディ

  砂留 広伸; 村瀬 公彦; 田原 康玄; 南 卓馬; 武山 博文; 高橋 順美; 松本 健; 濱田 哲; 長崎 忠雄; 谷澤 公伸; 半田 知宏; 松本 久子; 若村 智子; 森田 智視; 平井 豊博; 松田 文彦; 陳 和夫

  日本呼吸器学会誌, Apr. 2021

  
• 成人発症喘息と血清脂肪酸との関係 ながはま疫学研究

  田嶋 範之; 松本 久子; 寺田 悟; 西 健太; 古郷 摩利子; 野村 奈都子; 森本 千絵; 砂留 広伸; 長崎 忠雄; 小熊 毅; 中塚 賀也; 村瀬 公彦; 川口 喬久; 田原 康玄; 陳 和夫; 園村 和弘; 松田 文彦; 平井 豊博

  日本呼吸器学会誌, Apr. 2021

  
• Assessment of serum periostin level as a predictor of requirement for intensive treatment for type-2 inflammation in asthmatics in future: A follow-up study of the KiHAC cohort.

  Hironobu Sunadome; Hisako Matsumoto; Yuji Tohda; Takahiko Horiguchi; Hideo Kita; Kazunobu Kuwabara; Keisuke Tomii; Kojiro Otsuka; Masaki Fujimura; Noriyuki Ohkura; Takashi Iwanaga; Soichiro Hozawa; Akio Niimi; Yoshihiro Kanemitsu; Tadao Nagasaki; Noriyuki Tashima; Yumi Ishiyama; Chie Morimoto; Tsuyoshi Oguma; Tomoko Tajiri; Isao Ito; Junya Ono; Shoichiro Ohta; Kenji Izuhara; Toyohiro Hirai

  Allergology international : official journal of the Japanese Society of Allergology, Apr. 2021

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• Evaluation of Respiratory Mechanics With Dynamic Breathing Magnetic Resonance Imaging in Pleuroparenchymal Fibroelastosis: Limited Lower Chest Wall Motion and Preserved Diaphragm Motion.

  Satoshi Hamada; Tomohiro Handa; Toyohiro Hirai

  Archivos de bronconeumologia, 09 Mar. 2021

  
• Associations of CT evaluations of antigravity muscles, emphysema and airway disease with longitudinal outcomes in patients with COPD.

  Naoya Tanabe; Susumu Sato; Kazuya Tanimura; Tsuyoshi Oguma; Atsuyasu Sato; Shigeo Muro; Toyohiro Hirai

  Thorax, Mar. 2021

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• Is High-Flow Nasal Cannula Oxygen Therapy an Aerosol-Generating Medical Procedure?

  Satoshi Hamada; Naoya Tanabe; Hideki Inoue; Toyohiro Hirai

  Archivos de bronconeumologia, 03 Feb. 2021

  
• Directed induction of alveolar type I cells derived from pluripotent stem cells via Wnt signaling inhibition.

  Shuhei Kanagaki; Satoshi Ikeo; Takahiro Suezawa; Yuki Yamamoto; Masahide Seki; Toyohiro Hirai; Masatoshi Hagiwara; Yutaka Suzuki; Shimpei Gotoh

  Stem cells (Dayton, Ohio), Feb. 2021

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• 慢性呼吸器疾患における呼吸検知センサーTeleOxの有用性の検討

  濱田 哲; 半田 知宏; 田辺 直也; 中塚 賀也; 谷澤 公伸; 佐藤 篤靖; 佐藤 晋; 陳 和夫; 平井 豊博

  日本呼吸ケア・リハビリテーション学会誌, Feb. 2021

  
• うつ病性障害併存COPD患者におけるCOPDアセスメントテスト

  濱川 瑤子; 佐藤 晋; 室 繁郎; 田辺 直也; 渡邊 アヤ; 島 寛; 谷村 和哉; 佐藤 篤靖; 福井 基成; 平井 豊博

  日本呼吸ケア・リハビリテーション学会誌, Feb. 2021

  
• 胸部CTで評価した脊柱起立筋横断面積、肺気腫病変、気道病変がCOPD患者の長期予後に与える影響

  田辺 直也; 佐藤 晋; 谷村 和哉; 佐藤 篤靖; 室 繁郎; 平井 豊博

  日本呼吸ケア・リハビリテーション学会誌, Feb. 2021

  
• Impact of sleep-disordered breathing on glucose metabolism among individuals with a family history of diabetes: the Nagahama study.

  Takuma Minami; Takeshi Matsumoto; Yasuharu Tabara; David Gozal; Dale Smith; Kimihiko Murase; Kiminobu Tanizawa; Naomi Takahashi; Yoshinari Nakatsuka; Satoshi Hamada; Tomohiro Handa; Hirofumi Takeyama; Toru Oga; Isuzu Nakamoto; Tomoko Wakamura; Naoko Komenami; Kazuya Setoh; Takanobu Tsutsumi; Takahisa Kawaguchi; Yoichiro Kamatani; Yoshimitsu Takahashi; Satoshi Morita; Takeo Nakayama; Toyohiro Hirai; Fumihiko Matsuda; Kazuo Chin

  Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 01 Feb. 2021

  
• PD-L1 polymorphisms predict survival outcomes in advanced non-small-cell lung cancer patients treated with PD-1 blockade

  Hironori Yoshida; Takashi Nomizo; Hiroaki Ozasa; Takahiro Tsuji; Tomoko Funazo; Yuto Yasuda; Hitomi Ajimizu; Masatoshi Yamazoe; Kiyomitsu Kuninaga; Tatsuya Ogimoto; Kazutaka Hosoya; Ryo Itotani; Yuichi Sakamori; Young Hak Kim; Toyohiro Hirai

  European Journal of Cancer, Feb. 2021

  
• Gastroesophageal reflux disease is a risk factor for sputum production in the general population: the Nagahama study.

  Chie Morimoto; Hisako Matsumoto; Tadao Nagasaki; Yoshihiro Kanemitsu; Yumi Ishiyama; Hironobu Sunadome; Tsuyoshi Oguma; Isao Ito; Kimihiko Murase; Takahisa Kawaguchi; Yasuharu Tabara; Akio Niimi; Shigeo Muro; Fumihiko Matsuda; Kazuo Chin; Toyohiro Hirai

  Respiratory research, 06 Jan. 2021

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• Similar distribution of peripheral blood eosinophil counts in European and East Asian populations from investigations of large-scale general population studies: the Nagahama Study.

  Hironobu Sunadome; Susumu Sato; Hisako Matsumoto; Kimihiko Murase; Takahisa Kawaguchi; Yasuharu Tabara; Kazuo Chin; Fumihiko Matsuda; Toyohiro Hirai

  The European respiratory journal, Jan. 2021

  
• Central airway and peripheral lung structures in airway disease-dominant COPD.

  Naoya Tanabe; Kaoruko Shimizu; Kunihiko Terada; Susumu Sato; Masaru Suzuki; Hiroshi Shima; Akira Oguma; Tsuyoshi Oguma; Satoshi Konno; Masaharu Nishimura; Toyohiro Hirai

  ERJ open research, Jan. 2021

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• Night-time frequency of urination as a manifestation of sleep-disordered breathing: the Nagahama study.

  Satoshi Hamada; Yasuharu Tabara; Kimihiko Murase; Takeshi Matsumoto; Kazuya Setoh; Tomoko Wakamura; Takahisa Kawaguchi; Shinji Kosugi; Takeo Nakayama; Toyohiro Hirai; Fumihiko Matsuda; Kazuo Chin

  Sleep medicine, Jan. 2021

  
• High-flow nasal cannula oxygen therapy: Alternative respiratory therapy for severe post-transplant hypoxemia in children with hepatopulmonary syndrome.

  Satoshi Hamada; Tatsuya Okamoto; Eri Ogawa; Mari Sonoda; Hideaki Okajima; Toyohiro Hirai; Tomohiro Handa; Shinji Uemoto; Kazuo Chin

  Pediatric transplantation, Dec. 2020

  
• Disproportionally Impaired Diffusion Capacity Relative to Airflow Limitation in COPD.

  Naoya Tanabe; Chin Kook Rhee; Susumu Sato; Shigeo Muro; Hiroshi Shima; Kazuya Tanimura; Ki-Suck Jung; Kwang Ha Yoo; Toyohiro Hirai

  COPD, Dec. 2020

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• 気管支喘息との鑑別を要した特発性声門下狭窄の1例

  西 健太; 松本 久子; 寺田 悟; 小熊 毅; 岸本 曜; 平井 豊博

  日本呼吸器学会誌, Nov. 2020

  
• Dupilumab maintenance therapy in an asthmatic patient with coronavirus disease 2019 pneumonia

  Naoya Tanabe; Hisako Matsumoto; Satoshi Hamada; Isao Ito; Toyohiro Hirai

  Allergology International, Nov. 2020

  
• Delayed Right Main Bronchus Stenosis With Involvement of the Tracheal Carina After Blunt Chest Trauma: Successful Treatment With Tracheobronchial Anastomosis.

  Satoshi Hamada; Akihiro Ohsumi; Tatsuya Goto; Masatsugu Hamaji; Hiroshi Date; Toyohiro Hirai

  Archivos de bronconeumologia, 03 Oct. 2020

  
• 進行非小細胞肺癌におけるCBDCA+PEM+BEV療法後のBEV、PEM、PEM+BEV維持療法を比較したランダム化第II相試験

  金田 俊彦; 吉田 博徳; 金 永学; 阪森 優一; 永井 宏樹; 小笹 裕晃; 吉岡 弘鎮; 仲川 宏昭; 富井 啓介; 岡田 あすか; 吉村 健一; 平林 正孝; 平井 豊博

  肺癌, Oct. 2020

  
• Focal eosinophilic myositis with Charcot-Leyden crystal formation.

  Satoshi Hamada; Shigeharu Ueki; Yui Miyabe; Mitsuhiro Tsukino; Toyohiro Hirai

  Allergology international : official journal of the Japanese Society of Allergology, Oct. 2020

  
• Profibrotic function of pulmonary group 2 innate lymphoid cells is controlled by Regnase-1

  Yoshinari Nakatsuka; Ai Yaku; Tomohiro Handa; Alexis Vandenbon; Yuki Hikichi; Yasutaka Motomura; Ayuko Sato; Masanori Yoshinaga; Kiminobu Tanizawa; Kizuku Watanabe; Toyohiro Hirai; Kazuo Chin; Yutaka Suzuki; Takuya Uehata; Takashi Mino; Tohru Tsujimura; Kazuyo Moro; Osamu Takeuchi

  European Respiratory Journal, 25 Sep. 2020

  
• Morphological and functional reserves of the right middle lobe: Radiological analysis of changes after right lower lobectomy in healthy individuals.

  Hiroya Yamagishi; Toyofumi F Chen-Yoshikawa; Tsuyoshi Oguma; Toyohiro Hirai; Hiroshi Date

  The Journal of thoracic and cardiovascular surgery, 12 Aug. 2020

  
• 呼吸管理 睡眠呼吸障害および血圧が尿中アルブミン量に与える影響 ながはまスタディ

  村瀬 公彦; 松本 健; 田原 康玄; 南 卓馬; 高橋 順美; 武山 博文; 濱田 哲; 金井 修; 若村 智子; 米浪 直子; 平井 豊博; 松田 文彦; 陳 和夫

  日本呼吸器学会誌, Aug. 2020

  
• 動脈硬化リスク因子が睡眠時無呼吸症候群と動脈硬化の関連性に及ぼす影響についての検討 ながはまスタディ

  中塚 賀也; 村瀬 公彦; 濱田 哲; 武山 博文; 松本 健; 高橋 順美; 谷澤 公伸; 半田 知宏; 田原 康玄; 平井 豊博; 森田 智視; 中山 健夫; 松田 文彦; 陳 和夫

  日本呼吸器学会誌, Aug. 2020

  
• 誤嚥性肺炎の予後と入院期間長期化に関する因子の検討

  大井 一成; 伊藤 功朗; 田辺 直也; 小西 聡史; 白田 全弘; 濱尾 信叔; 平井 豊博

  日本呼吸器学会誌, Aug. 2020

  
• 肺炎入院患者の喀痰から入院中にMRSAが分離されるリスク因子の検討

  白田 全弘; 伊藤 功朗; 田辺 直也; 小西 聡史; 大井 一成; 濱尾 信叔; 安友 佳朗; 門脇 誠三; 平井 豊博

  日本呼吸器学会誌, Aug. 2020

  
• アトピー型重症喘息例の下気道での細菌定着と炎症との関係

  田嶋 範之; 松本 久子; 田尻 智子; 森本 千絵; 古郷 摩利子; 野村 奈都子; 砂留 広伸; 小熊 毅; 太田 昭一郎; 小野 純也; 小賀 徹; 新実 彰男; 出原 賢治; 平井 豊博

  日本呼吸器学会誌, Aug. 2020

  
• 生後肺発達不良における肺胞構成細胞間相互連関の異常とその介在因子の検討

  水谷 達志; 佐藤 篤靖; 平田 直; 進藤 允; 渡邉 アヤ; 濱川 瑶子; 上桝 潔; 谷村 和哉; 田辺 直也; 佐藤 晋; 平井 豊博

  日本呼吸器学会誌, Aug. 2020

  
• アレルギー性気道炎症の機序 気道リモデリングにおけるinducible Bronchial Associated Lymphoid Tissue(iBALT)の役割

  渡邉 アヤ; 佐藤 篤靖; 平田 直; 進藤 允; 水谷 達志; 濱川 瑶子; 上桝 潔; 谷村 和哉; 田辺 直也; 佐藤 晋; 平井 豊博

  日本呼吸器学会誌, Aug. 2020

  
• ヒト肺気腫表現型を規定する末梢気道セリンプロテアーゼバランスについての検討

  上桝 潔; 佐藤 篤靖; 田辺 直也; 長谷川 浩一; 谷村 和哉; 濱川 瑶子; 水谷 達志; 佐藤 晋; 小川 惠美子; 室 繁郎; 平井 豊博

  日本呼吸器学会誌, Aug. 2020

  
• COPDの身体活動性低下と吸気呼気CTで評価した葉別air trappingの関連

  濱川 瑶子; 田辺 直也; 佐藤 晋; 寺田 邦彦; 島 寛; 金崎 雅史; 小熊 毅; 谷村 和哉; 佐藤 篤靖; 平井 豊博

  日本呼吸器学会誌, Aug. 2020

  
• COPDにおける気管支肺容積比と末梢気道病変との関係

  島 寛; 田辺 直也; 小熊 毅; 佐藤 晋; 寺田 邦彦; 濱川 瑶子; 久保 武; 小澤 聡; 佐藤 篤靖; 平井 豊博

  日本呼吸器学会誌, Aug. 2020

  
• 喘息既往で層別化した超高精細CTによるCOPDの気道形態解析

  田辺 直也; 小熊 毅; 佐藤 晋; 島 寛; 久保 武; 小澤 聡; 佐藤 篤靖; 松本 久子; 富樫 かおり; 平井 豊博

  日本呼吸器学会誌, Aug. 2020

  
• 気管支拡張症における黄色ブドウ球菌エンテロトキシン感作に関する検討

  森本 千絵; 松本 久子; 小熊 毅; 伊藤 功朗; 佐藤 晋; 佐藤 篤靖; 古郷 摩利子; 野村 奈都子; 田嶋 範之; 砂留 広伸; 平井 豊博

  日本呼吸器学会誌, Aug. 2020

  
• 急速な抗重力筋減少はCOPDの短期予後と関連する

  谷村 和哉; 佐藤 晋; 佐藤 篤靖; 田辺 直也; 長谷川 浩一; 上桝 潔; 濱川 瑶子; 小熊 毅; 室 繁郎; 平井 豊博

  日本呼吸器学会誌, Aug. 2020

  
• 病診薬連携で行う吸入支援のアウトカムの評価

  鋒山 香苗; 杉本 充弘; 米澤 淳; 寺尾 真琴; 山本 浩貴; 吉田 優子; 朝倉 佳代子; 深津 祥央; 谷村 和哉; 佐藤 晋; 松本 久子; 中川 俊作; 北田 徳昭; 平井 豊博; 松原 和夫

  医療薬学, Aug. 2020

  
• 生後肺発達不良における肺胞構成細胞間相互連関の異常とその介在因子の検討

  水谷 達志; 佐藤 篤靖; 平田 直; 進藤 允; 渡邉 アヤ; 濱川 瑶子; 上桝 潔; 谷村 和哉; 田辺 直也; 佐藤 晋; 平井 豊博

  日本呼吸器学会誌, Aug. 2020

  
• アレルギー性気道炎症の機序 気道リモデリングにおけるinducible Bronchial Associated Lymphoid Tissue(iBALT)の役割

  渡邉 アヤ; 佐藤 篤靖; 平田 直; 進藤 允; 水谷 達志; 濱川 瑶子; 上桝 潔; 谷村 和哉; 田辺 直也; 佐藤 晋; 平井 豊博

  日本呼吸器学会誌, Aug. 2020

  
• ヒト肺気腫表現型を規定する末梢気道セリンプロテアーゼバランスについての検討

  上桝 潔; 佐藤 篤靖; 田辺 直也; 長谷川 浩一; 谷村 和哉; 濱川 瑶子; 水谷 達志; 佐藤 晋; 小川 惠美子; 室 繁郎; 平井 豊博

  日本呼吸器学会誌, Aug. 2020

  
• COPDの身体活動性低下と吸気呼気CTで評価した葉別air trappingの関連

  濱川 瑶子; 田辺 直也; 佐藤 晋; 寺田 邦彦; 島 寛; 金崎 雅史; 小熊 毅; 谷村 和哉; 佐藤 篤靖; 平井 豊博

  日本呼吸器学会誌, Aug. 2020

  
• COPDにおける気管支肺容積比と末梢気道病変との関係

  島 寛; 田辺 直也; 小熊 毅; 佐藤 晋; 寺田 邦彦; 濱川 瑶子; 久保 武; 小澤 聡; 佐藤 篤靖; 平井 豊博

  日本呼吸器学会誌, Aug. 2020

  
• 喘息既往で層別化した超高精細CTによるCOPDの気道形態解析

  田辺 直也; 小熊 毅; 佐藤 晋; 島 寛; 久保 武; 小澤 聡; 佐藤 篤靖; 松本 久子; 富樫 かおり; 平井 豊博

  日本呼吸器学会誌, Aug. 2020

  
• 気管支拡張症における黄色ブドウ球菌エンテロトキシン感作に関する検討

  森本 千絵; 松本 久子; 小熊 毅; 伊藤 功朗; 佐藤 晋; 佐藤 篤靖; 古郷 摩利子; 野村 奈都子; 田嶋 範之; 砂留 広伸; 平井 豊博

  日本呼吸器学会誌, Aug. 2020

  
• 急速な抗重力筋減少はCOPDの短期予後と関連する

  谷村 和哉; 佐藤 晋; 佐藤 篤靖; 田辺 直也; 長谷川 浩一; 上桝 潔; 濱川 瑶子; 小熊 毅; 室 繁郎; 平井 豊博

  日本呼吸器学会誌, Aug. 2020

  
• Airway clearance ameliorated the control of diffuse panbronchiolitis accompanied by asthma and leukocytoclastic vasculitis.

  Noriyuki Tashima; Hisako Matsumoto; Natsuko Nomura; Akihiko Yoshizawa; Akihiko Kitoh; Kenji Kabashima; Toyohiro Hirai

  Allergology international : official journal of the Japanese Society of Allergology, 28 Jul. 2020

  
• Home device-monitored sleep blood pressure reflects large artery stiffness: the Nagahama study.

  Yasuharu Tabara; Takeshi Matsumoto; Kimihiko Murase; Kazuya Setoh; Takahisa Kawaguchi; Shinji Kosugi; Takeo Nakayama; Toyohiro Hirai; Tomoko Wakamura; Kazuo Chin; Fumihiko Matsuda

  Journal of hypertension, 15 Jul. 2020, Peer-reviewed

  
• HTLV-1関連気管支肺疾患の長期観察例

  橋本 健太郎; 松本 久子; 黒澤 学; 菱澤 方勝; 高折 晃史; 平井 豊博

  日本呼吸器学会誌, Jul. 2020

  
• Role of serum periostin in severe obstructive sleep apnea with albuminuria: an observational study.

  Hironobu Sunadome; Hisako Matsumoto; Ryo Tachikawa; Takeshi Matsumoto; Kiminobu Tanizawa; Toru Oga; Junya Ono; Shoichiro Ohta; Kenji Izuhara; Toyohiro Hirai; Kazuo Chin

  Respiratory research, 09 Jun. 2020, Peer-reviewed

  
• Comparison of ceftriaxone plus macrolide and ampicillin/sulbactam plus macrolide in treatment for patients with community-acquired pneumonia without risk factors for aspiration: an open-label, quasi-randomized, controlled trial.

  Nobuyoshi Hamao; Isao Ito; Satoshi Konishi; Naoya Tanabe; Masahiro Shirata; Issei Oi; Mitsuhiro Tsukino; Hisako Matsumoto; Yoshiro Yasutomo; Seizo Kadowaki; Toyohiro Hirai

  BMC pulmonary medicine, 05 Jun. 2020, Peer-reviewed

  
• Acquired Resistance to Alectinib in ALK-Rearranged Lung Cancer due to ABCC11/MRP8 Overexpression in a Clinically Paired Resistance Model.

  Tomoko Funazo; Takahiro Tsuji; Hiroaki Ozasa; Koh Furugaki; Yasushi Yoshimura; Tetsuya Oguri; Hitomi Ajimizu; Yuto Yasuda; Takashi Nomizo; Yuichi Sakamori; Hironori Yoshida; Young Hak Kim; Toyohiro Hirai

  Molecular cancer therapeutics, Jun. 2020, Peer-reviewed

  
• High serum free IL-18 is associated with decreased omalizumab efficacy: findings from a 2-year omalizumab treatment study.

  Chie Morimoto; Hisako Matsumoto; Tomoko Tajiri; Yasuhiro Gon; Reiko Ito; Shu Hashimoto; Maho Suzukawa; Ken Ohta; Kenji Izuhara; Junya Ono; Shoichiro Ohta; Isao Ito; Tsuyoshi Oguma; Yoshihiro Kanemitsu; Tadao Nagasaki; Yumi Izuhara; Akio Niimi; Toyohiro Hirai

  The Journal of asthma : official journal of the Association for the Care of Asthma, 20 May 2020, Peer-reviewed

  
• Sleep disordered breathing and metabolic comorbidities across gender and menopausal status in East Asians; the Nagahama Study.

  Takeshi Matsumoto; Kimihiko Murase; Yasuharu Tabara; Takuma Minami; Osamu Kanai; Hirofumi Takeyama; Naomi Takahashi; Satoshi Hamada; Kiminobu Tanizawa; Tomoko Wakamura; Naoko Komenami; Kazuya Setoh; Takahisa Kawaguchi; Takanobu Tsutsumi; Satoshi Morita; Yoshimitsu Takahashi; Takeo Nakayama; Toyohiro Hirai; Fumihiko Matsuda; Kazuo Chin

  The European respiratory journal, 13 May 2020, Peer-reviewed

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• 肺MAC症治療中に胸部画像所見が一過性に悪化したAIDS患者の1例

  軸屋 紀宏; 伊藤 功朗; 白田 全弘; 大井 一成; 濱尾 信叔; 今井 誠一郎; 白川 康太郎; 平井 豊博

  感染症学雑誌, May 2020

  
• A Randomized Phase II Study of Maintenance Bevacizumab, Pemetrexed or Bevacizumab Plus Pemetrexed for Advanced Non-squamous Non-small Cell Lung Cancer.

  Hironori Yoshida; Young Hak Kim; Yuichi Sakamori; Hiroki Nagai; Hiroaki Ozasa; Toshihiko Kaneda; Hiroshige Yoshioka; Hiroaki Nakagawa; Keisuke Tomii; Asuka Okada; Kenichi Yoshimura; Masataka Hirabayashi; Toyohiro Hirai

  Anticancer research, May 2020, Peer-reviewed

  
• 安定期COPD患者の栄養状態に対する鍼治療の効果(Effects of acupuncture on nutritional state of patients with stable chronic obstructive pulmonary disease(COPD):re-analysis of COPD acupuncture trial,a randomized controlled trial)

  鈴木 雅雄; 室 繁郎; 福井 基成; 石崎 直人; 佐藤 晋; 塩田 哲広; 遠藤 和夫; 鈴木 朋子; 三潴 忠道; 三嶋 理晃; 平井 豊博

  福島医学雑誌, Apr. 2020

  
• Low serum free light chain is associated with risk of COPD exacerbation.

  Kazuya Tanimura; Susumu Sato; Atsuyasu Sato; Naoya Tanabe; Koichi Hasegawa; Kiyoshi Uemasu; Yoko Hamakawa; Toyohiro Hirai; Shigeo Muro

  ERJ open research, Apr. 2020, Peer-reviewed

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• Accelerated Loss of Antigravity Muscles Is Associated with Mortality in Patients with COPD.

  Kazuya Tanimura; Susumu Sato; Atsuyasu Sato; Naoya Tanabe; Koichi Hasegawa; Kiyoshi Uemasu; Yoko Hamakawa; Tsuyoshi Oguma; Shigeo Muro; Toyohiro Hirai

  Respiration; international review of thoracic diseases, 01 Apr. 2020, Peer-reviewed

  
• MCL1 inhibition is effective against a subset of small-cell lung cancer with high MCL1 and low BCL-XL expression.

  Yuto Yasuda; Hiroaki Ozasa; Young Hak Kim; Masatoshi Yamazoe; Hitomi Ajimizu; Tomoko Yamamoto Funazo; Takashi Nomizo; Takahiro Tsuji; Hironori Yoshida; Yuichi Sakamori; Naoki Nakajima; Toshi Menju; Akihiko Yoshizawa; Hiroshi Date; Toyohiro Hirai

  Cell death & disease, 09 Mar. 2020, Peer-reviewed

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• 誤嚥性肺炎患者における再発熱のリスク因子

  濱尾 信叔; 伊藤 功朗; 小西 聡史; 白田 全弘; 大井 一成; 安友 佳朗; 平井 豊博; 門脇 誠三; 田辺 直也; 月野 光博

  感染症学雑誌, Mar. 2020

  
• A Randomized Controlled Trial of Telemedicine for Long-Term Sleep Apnea Continuous Positive Airway Pressure Management

  Kimihiko Murase; Kiminobu Tanizawa; Takuma Minami; Takeshi Matsumoto; Ryo Tachikawa; Naomi Takahashi; Toru Tsuda; Yoshiro Toyama; Motoharu Ohi; Toshiki Akahoshi; Yasuhiro Tomita; Koji Narui; Hiroshi Nakamura; Tetsuro Ohdaira; Hiroyuki Yoshimine; Tomomasa Tsuboi; Yoshihiro Yamashiro; Shinichi Ando; Takatoshi Kasai; Hideo Kita; Koichiro Tatsumi; Naoto Burioka; Keisuke Tomii; Yasuhiro Kondoh; Hirofumi Takeyama; Tomohiro Handa; Satoshi Hamada; Toru Oga; Takeo Nakayama; Tetsuo Sakamaki; Satoshi Morita; Tomohiro Kuroda; Toyohiro Hirai; Kazuo Chin

  ANNALS OF THE AMERICAN THORACIC SOCIETY, Mar. 2020, Peer-reviewed

  
• Phase II Study of Consolidation Amrubicin After Concurrent Chemoradiotherapy in Patients With Limited-stage Small-cell Lung Cancer

  Hironori Yoshida; Hiroki Nagai; Yuichi Sakamori; Hiroaki Ozasa; Takashi Nishimura; Keisuke Tomii; Toyohiro Hirai; Yukinori Matsuo; Yusuke Iizuka; Takashi Mizowaki; Kenichi Yoshimura; Young Hak Kim

  IN VIVO, Mar. 2020, Peer-reviewed

  
• Serine Protease Imbalance in the Small Airways and Development of Centrilobular Emphysema in COPD.

  Kiyoshi Uemasu; Naoya Tanabe; Kazuya Tanimura; Koichi Hasegawa; Tatsushi Mizutani; Yoko Hamakawa; Susumu Sato; Emiko Ogawa; Matthew J Thomas; Machiko Ikegami; Shigeo Muro; Toyohiro Hirai; Atsuyasu Sato

  American journal of respiratory cell and molecular biology, 26 Feb. 2020, Peer-reviewed

  
• Lobar distribution of non-emphysematous gas trapping and lung hyperinflation in chronic obstructive pulmonary disease.

  Hiroshi Shima; Naoya Tanabe; Susumu Sato; Tsuyoshi Oguma; Takeshi Kubo; Satoshi Kozawa; Koji Koizumi; Aya Watanabe; Atsuyasu Sato; Kaori Togashi; Toyohiro Hirai

  Respiratory investigation, 19 Feb. 2020, Peer-reviewed

  
• Cefepime vs. meropenem for moderate-to-severe pneumonia in patients at risk for aspiration: An open-label, randomized study

  Issei Oi; Isao Ito; Naoya Tanabe; Satoshi Konishi; Nobuyoshi Hamao; Yoshiro Yasutomo; Seizo Kadowaki; Toyohiro Hirai

  Journal of Infection and Chemotherapy, Feb. 2020

  
• Quantitative analysis of computed tomography of the lungs in patients with lymphangioleiomyomatosis treated with sirolimus.

  Yuki Ko; Katsuaki Asakawa; Kazunori Tobino; Tsuyoshi Oguma; Toyohiro Hirai; Toshinori Takada; Kazuhisa Takahashi; Kuniaki Seyama

  Heliyon, Feb. 2020

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• Treatment of Mycobacterium avium–intracellulare complex lung disease in the real world: a retrospective big data analysis

  Tomohide Iwao; Genta Kato; Isao Ito; Toyohiro Hirai; Tomohiro Kuroda

  Drugs and Therapy Perspectives, 01 Feb. 2020, Peer-reviewed

  
• Per cent low attenuation volume and fractal dimension of low attenuation clusters on CT predict different long-term outcomes in COPD.

  Kaoruko Shimizu; Naoya Tanabe; Nguyen Van Tho; Masaru Suzuki; Hironi Makita; Susumu Sato; Shigeo Muro; Michiaki Mishima; Toyohiro Hirai; Emiko Ogawa; Yasutaka Nakano; Satoshi Konno; Masaharu Nishimura

  Thorax, Feb. 2020, Peer-reviewed

  
• Combination of host immune metabolic biomarkers for the PD-1 blockade cancer immunotherapy.

  Ryusuke Hatae; Kenji Chamoto; Young Hak Kim; Kazuhiro Sonomura; Kei Taneishi; Shuji Kawaguchi; Hironori Yoshida; Hiroaki Ozasa; Yuichi Sakamori; Maryam Akrami; Sidonia Fagarasan; Izuru Masuda; Yasushi Okuno; Fumihiko Matsuda; Toyohiro Hirai; Tasuku Honjo

  JCI insight, 30 Jan. 2020, Peer-reviewed

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• YAP1 mediates survival of ALK-rearranged lung cancer cells treated with alectinib via pro-apoptotic protein regulation

  Takahiro Tsuji; Hiroaki Ozasa; Wataru Aoki; Shunsuke Aburaya; Tomoko Yamamoto Funazo; Koh Furugaki; Yasushi Yoshimura; Masatoshi Yamazoe; Hitomi Ajimizu; Yuto Yasuda; Takashi Nomizo; Hironori Yoshida; Yuichi Sakamori; Hiroaki Wake; Mitsuyoshi Ueda; Young Hak Kim; Toyohiro Hirai

  Nature Communications, 03 Jan. 2020, Peer-reviewed

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• Fractal Analysis of Lung Structure in Chronic Obstructive Pulmonary Disease.

  Naoya Tanabe; Susumu Sato; Béla Suki; Toyohiro Hirai

  Frontiers in physiology, 2020

  
• A method of generating alveolar organoids using human pluripotent stem cells.

  Yuki Yamamoto; Yohei Korogi; Toyohiro Hirai; Shimpei Gotoh

  Methods in cell biology, 2020

  
• Validation of a new serum granulocyte-macrophage colony-stimulating factor autoantibody testing kit

  Koh Nakata; Tatsuki Sugi; Keiko Kuroda; Kazutaka Yoshizawa; Toshinori Takada; Ryushi Tazawa; Takahiro Ueda; Ami Aoki; Mitsuhiro Abe; Koichiro Tatsumi; Ryosuke Eda; Shotaro Kondoh; Konosuke Morimoto; Takeshi Tanaka; Etsuro Yamaguchi; Ayumu Takahashi; Miku Oda; Haruyuki Ishii; Shinyu Izumi; Haruhito Sugiyama; Atsushi Nakagawa; Keisuke Tomii; Masaru Suzuki; Satoshi Konno; Shinya Ohkouchi; Taizou Hirano; Tomohiro Handa; Toyohiro Hirai; Yoshikazu Inoue; Toru Arai; Katsuaki Asakawa; Takuro Sakagami; Takahiro Tanaka; Ayako Mikami; Nobutaka Kitamura

  ERJ OPEN RESEARCH, Jan. 2020

  
• Correlation between eosinophil count, its genetic background and body mass index: The Nagahama Study.

  Hironobu Sunadome; Hisako Matsumoto; Yumi Izuhara; Tadao Nagasaki; Yoshihiro Kanemitsu; Yumi Ishiyama; Chie Morimoto; Tsuyoshi Oguma; Isao Ito; Kimihiko Murase; Shigeo Muro; Takahisa Kawaguchi; Yasuharu Tabara; Kazuo Chin; Fumihiko Matsuda; Toyohiro Hirai

  Allergology international : official journal of the Japanese Society of Allergology, Jan. 2020, Peer-reviewed

  
• Nocturnal hypercapnia with daytime normocapnia in patients with advanced pulmonary arterial hypertension awaiting lung transplantation.

  Yoshinari Nakatsuka; Toyofumi Chen-Yoshikawa; Hideyuki Kinoshita; Akihiro Aoyama; Hiroyasu Kubo; Kimihiko Murase; Satoshi Hamada; Hirofumi Takeyama; Takuma Minami; Naomi Takahashi; Kiminobu Tanizawa; Tomohiro Handa; Toyohiro Hirai; Hiroshi Date; Kazuo Chin

  PloS one, 2020, Peer-reviewed

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• Soft tissue infection caused by Mycolicibacter kumamotonensis.

  Maho Iemura-Kashiwagi; Isao Ito; Ryosuke Ikeguchi; Masatoshi Kadoya; Tomoki Iemura; Shiomi Yoshida; Katsuhiro Suzuki; Toyohiro Hirai

  Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, Jan. 2020, Peer-reviewed

  
• Management and Outcomes of Newly Diagnosed Non-Small Cell Lung Cancer Patients with Brain Metastases: A Real-World Study in Japan.

  Hironori Yoshida; Young Hak Kim; Shigeaki Iwatsubo; Chikara Sakaguchi; Yuichi Sakamori; Hiroki Nagai; Hiroaki Ozasa; Tadashi Mio; Toyohiro Hirai

  Oncology, 2020, Peer-reviewed

  
• Phenotyping of IgG4-related diseases based on affected organ pattern: A multicenter cohort study using cluster analysis

  Takafumi Niwamoto; Tomohiro Handa; Shoko Matsui; Hiroshi Yamamoto; Hajime Yoshifuji; Hiroyasu Abe; Hisako Matsumoto; Yuzo Kodama; Tsutomu Chiba; Hiroshi Seno; Tsuneyo Mimori; Toyohiro Hirai

  Modern Rheumatology, 2020, Peer-reviewed

  
• Clinical significance of self-reported cough intensity and frequency in patients with interstitial lung disease: a cross-sectional study

  Ryuhei Sato; Tomohiro Handa; Hisako Matsumoto; Takeshi Kubo; Toyohiro Hirai

  BMC Pulmonary Medicine, Dec. 2019, Peer-reviewed

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• Frequent nocturnal urination in older men is associated with arterial stiffness: The Nagahama study.

  Yasuharu Tabara; Takeshi Matsumoto; Kimihiko Murase; Kazuya Setoh; Takahisa Kawaguchi; Shunsuke Nagashima; Shinji Kosugi; Toyohiro Hirai; Takeo Nakayama; Tomoko Wakamura; Kazuo Chin; Fumihiko Matsuda

  Hypertension research : official journal of the Japanese Society of Hypertension, Dec. 2019, Peer-reviewed

  
• Regional lung deflation with increased airway volume underlies the functional response to bronchodilators in chronic obstructive pulmonary disease.

  Naoya Tanabe; Susumu Sato; Shigeo Muro; Hiroshi Shima; Tsuyoshi Oguma; Kazuya Tanimura; Atsuyasu Sato; Toyohiro Hirai

  Physiological reports, Dec. 2019, Peer-reviewed

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• Clinical impact of low serum free T4 in patients with non-small cell lung cancer treated with nivolumab.

  Tomoko Yamamoto Funazo; Takashi Nomizo; Hiroaki Ozasa; Takahiro Tsuji; Yuto Yasuda; Hironori Yoshida; Yuichi Sakamori; Hiroki Nagai; Toyohiro Hirai; Young Hak Kim

  Scientific reports, 19 Nov. 2019, Peer-reviewed

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• A Randomized Controlled Trial of Telemedicine for Long-Term Sleep Apnea CPAP Management.

  Murase K; Tanizawa K; Minami T; Matsumoto T; Tachikawa R; Takahashi N; Tsuda T; Toyama Y; Ohi M; Akahoshi T; Tomita Y; Narui K; Nakamura H; Ohdaira T; Yoshimine H; Tsuboi T; Yamashiro Y; Ando S; Kasai T; Kita H; Tatsumi K; Burioka N; Tomii K; Kondoh Y; Takeyama H; Handa T; Hamada S; Oga T; Nakayama T; Sakamaki T; Morita S; Kuroda T; Hirai T; Chin K

  Annals of the American Thoracic Society, Nov. 2019, Peer-reviewed

  
• Lifestyle habits associated with nocturnal urination frequency: The Nagahama study.

  Yasuharu Tabara; Takeshi Matsumoto; Kimihiko Murase; Kazuya Setoh; Takahisa Kawaguchi; Shunsuke Nagashima; Satoshi Funada; Shinji Kosugi; Toyohiro Hirai; Takeo Nakayama; Tomoko Wakamura; Kazuo Chin; Fumihiko Matsuda

  Neurourology and urodynamics, Nov. 2019, Peer-reviewed

  
• Direct evaluation of peripheral airways using ultra-high-resolution CT in chronic obstructive pulmonary disease.

  Naoya Tanabe; Hiroshi Shima; Susumu Sato; Tsuyoshi Oguma; Takeshi Kubo; Satoshi Kozawa; Koji Koizumi; Atsuyasu Sato; Kaori Togashi; Toyohiro Hirai

  European journal of radiology, Nov. 2019, Peer-reviewed

  
• ヘルマンスキー・パドラック症候群2型患者由来iPS細胞を用いて2型肺胞上皮細胞の機能異常を再現する

  興梠 陽平; 後藤 慎平; 池尾 聡; 山本 佑樹; 曽根 尚之; 玉井 浩二; 浅香 勲; 堀田 秋津; 平井 豊博

  日本肺サーファクタント・界面医学会雑誌, Oct. 2019, Peer-reviewed

  
• Association of weak hip abduction strength with nocturia in older women: The Nagahama study.

  Yasuharu Tabara; Tome Ikezoe; Takeshi Matsumoto; Kimihiko Murase; Kazuya Setoh; Satoshi Funada; Takahisa Kawaguchi; Shunsuke Nagashima; Shinji Kosugi; Toyohiro Hirai; Takeo Nakayama; Tomoko Wakamura; Kazuo Chin; Noriaki Ichihashi; Tadao Tsuboyama; Fumihiko Matsuda

  Geriatrics & gerontology international, Oct. 2019, Peer-reviewed

  
• Inhaled GM-CSF for Pulmonary Alveolar Proteinosis.

  Ryushi Tazawa; Takahiro Ueda; Mitsuhiro Abe; Koichiro Tatsumi; Ryosuke Eda; Shotaro Kondoh; Konosuke Morimoto; Takeshi Tanaka; Etsuro Yamaguchi; Ayumu Takahashi; Miku Oda; Haruyuki Ishii; Shinyu Izumi; Haruhito Sugiyama; Atsushi Nakagawa; Keisuke Tomii; Masaru Suzuki; Satoshi Konno; Shinya Ohkouchi; Naoki Tode; Tomohiro Handa; Toyohiro Hirai; Yoshikazu Inoue; Toru Arai; Katsuaki Asakawa; Takuro Sakagami; Atsushi Hashimoto; Takahiro Tanaka; Toshinori Takada; Ayako Mikami; Nobutaka Kitamura; Koh Nakata

  The New England journal of medicine, 05 Sep. 2019, Peer-reviewed

  
• Association between sleep disturbance and nocturnal blood pressure profiles by a linear mixed model analysis: the Nagahama study.

  Takeshi Matsumoto; Yasuharu Tabara; Kimihiko Murase; Kazuya Setoh; Takahisa Kawaguchi; Shunsuke Nagashima; Shinji Kosugi; Takeo Nakayama; Tomoko Wakamura; Toyohiro Hirai; Fumihiko Matsuda; Kazuo Chin

  Sleep medicine, Sep. 2019, Peer-reviewed

  
• 【コンピュータサイエンスの応用】胸部CT画像の解析手法と人工知能への応用

  小熊 毅; 平井 豊博

  THE LUNG-perspectives, Aug. 2019

  
• Vinculin is critical for the robustness of the epithelial cell sheet paracellular barrier for ions.

  Satoshi Konishi; Tomoki Yano; Hiroo Tanaka; Tomoaki Mizuno; Hatsuho Kanoh; Kazuto Tsukita; Toshinori Namba; Atsushi Tamura; Shigenobu Yonemura; Shimpei Gotoh; Hisako Matsumoto; Toyohiro Hirai; Sachiko Tsukita

  Life science alliance, Aug. 2019, Peer-reviewed

  
• In Vitro Disease Modeling of Hermansky-Pudlak Syndrome Type 2 Using Human Induced Pluripotent Stem Cell-Derived Alveolar Organoids.

  Yohei Korogi; Shimpei Gotoh; Satoshi Ikeo; Yuki Yamamoto; Naoyuki Sone; Koji Tamai; Satoshi Konishi; Tadao Nagasaki; Hisako Matsumoto; Isao Ito; Toyofumi F Chen-Yoshikawa; Hiroshi Date; Masatoshi Hagiwara; Isao Asaka; Akitsu Hotta; Michiaki Mishima; Toyohiro Hirai

  Stem cell reports, 09 Jul. 2019, Peer-reviewed

  
• ヒトiPS細胞由来肺胞オルガノドを用いたHermansky-Pudlak症候群2型の疾患モデリング

  興梠 陽平; 後藤 慎平; 池尾 聡; 山本 佑樹; 曽根 尚之; 玉井 浩二; 小西 聡史; 長崎 忠雄; 松本 久子; 伊藤 功朗; 陳 豊史; 伊達 洋至; 萩原 正敏; 浅香 勲; 堀田 秋津; 三嶋 理晃; 平井 豊博

  組織培養研究, Jun. 2019, Peer-reviewed

  
• 気管支鏡検査が診断に寄与した不全型ベーチェット病に合併した右肺動脈閉塞の1例

  興梠 陽平; 小橋 和世; 吉藤 元; 田中 望美; 笹井 蘭; 田崎 淳一; 半田 知宏; 久保 武; 渡邉 創; 谷澤 公伸; 中塚 賀也; 村瀬 裕子; 池上 直弥; 庭本 崇史; 中西 智子; 陳 和夫; 三森 経世; 平井 豊博

  気管支学, Jun. 2019, Peer-reviewed

  
• Breathing-Swallowing Discoordination Is Associated with Poor Prognosis in Patients with COPD

  S. Sato; S. Nagami; Y. Oku; A. Sato; N. Tanabe; N. Yagi; T. Hirai; S. Muro

  A41. COPD: EPIDEMIOLOGY, May 2019

  
• 気道炎症・バイオマーカー 喘息患者における将来的Omalizumab導入予測因子としてのペリオスチンの有用性の検討

  砂留 広伸; 松本 久子; 東田 有智; 堀口 高彦; 北 英夫; 富井 啓介; 藤村 政樹; 岩永 賢司; 保澤 総一郎; 新実 彰男; 金光 禎寛; 長崎 忠雄; 森本 千絵; 小熊 毅; 田尻 智子; 伊藤 功朗; 小野 純也; 太田 昭一郎; 出原 賢治; 平井 豊博; 近畿北陸気道疾患研究会(KiHAC)

  アレルギー, May 2019

  
• 気管支喘息の合併症 閉塞性気道疾患における黄色ブドウ球菌エンテロトキシンへの感作に関する検討

  森本 千絵; 松本 久子; 小熊 毅; 佐藤 晋; 佐藤 篤靖; 田嶋 範之; 石山 裕美; 砂留 広伸; 長崎 忠雄; 田辺 直也; 伊藤 功朗; 室 繁郎; 平井 豊博

  アレルギー, May 2019

  
• Associations of airway tree to lung volume ratio on computed tomography with lung function and symptoms in chronic obstructive pulmonary disease.

  Tanabe N; Sato S; Oguma T; Shima H; Sato A; Muro S; Hirai T

  Respiratory research, Apr. 2019, Peer-reviewed

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• Serum matrix metalloproteinase levels in polymyositis/dermatomyositis patients with interstitial lung disease.

  Yoshinari Nakatsuka; Tomohiro Handa; Ran Nakashima; Kiminobu Tanizawa; Takeshi Kubo; Yuko Murase; Akihiko Sokai; Kohei Ikezoe; Yuji Hosono; Kizuku Watanabe; Shinsaku Tokuda; Kazuko Uno; Akihiko Yoshizawa; Tatsuaki Tsuruyama; Ryuji Uozumi; Sonoko Nagai; Kazuhiro Hatta; Yoshio Taguchi; Michiaki Mishima; Kazuo Chin; Tsuneyo Mimori; Toyohiro Hirai

  Rheumatology (Oxford, England), 08 Mar. 2019, Peer-reviewed

  
• In Vitro Disease Modeling of Hermansky-Pudlak Syndrome Type 2 Using Human Induced Pluripotent Stem Cell-Derived Alveolar Organoids.

  Yohei Korogi; Shimpei Gotoh; Satoshi Ikeo; Yuki Yamamoto; Naoyuki Sone; Koji Tamai; Satoshi Konishi; Tadao Nagasaki; Hisako Matsumoto; Isao Ito; Toyofumi F Chen-Yoshikawa; Hiroshi Date; Masatoshi Hagiwara; Isao Asaka; Akitsu Hotta; Michiaki Mishima; Toyohiro Hirai

  Stem cell reports, 05 Mar. 2019, Peer-reviewed

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• 中等症〜重症の誤嚥性肺炎でのcefepimeとmeropenemの効果、安全性に関する単施設前向きランダム化比較試験

  大井 一成; 伊藤 功朗; 小西 聡史; 濱尾 信叔; 安友 佳朗; 平井 豊博; 門脇 誠三; 田辺 直也; 月野 光博

  感染症学雑誌, Mar. 2019

  
• 肺炎加療における抗菌薬副作用についての検討

  濱尾 信叔; 伊藤 功朗; 小西 聡史; 大井 一成; 安友 佳朗; 平井 豊博; 門脇 誠三; 田辺 直也; 月野 光博

  感染症学雑誌, Mar. 2019

  
• 喘息患者における将来的Omalizumab導入予測因子としてのペリオスチンの有用性の検討

  砂留 広伸; 松本 久子; 東田 有智; 堀口 高彦; 北 英夫; 桑原 和伸; 富井 啓介; 大塚 浩二郎; 藤村 政樹; 大倉 徳幸; 岩永 賢司; 保澤 総一郎; 新実 彰男; 金光 禎寛; 長崎 忠雄; 田嶋 範之; 石山 祐美; 森本 千絵; 小熊 毅; 田尻 智子; 伊藤 功朗; 小野 純也; 太田 昭一郎; 出原 賢治; 平井 豊博

  日本呼吸器学会誌, Mar. 2019

  
• 閉塞性気道疾患における黄色ブドウ球菌エンテロトキシン感作の役割

  森本 千絵; 松本 久子; 小熊 毅; 佐藤 晋; 佐藤 篤靖; 田嶋 範之; 石山 祐美; 砂留 広伸; 長崎 忠雄; 伊藤 功朗; 室 繁郎; 平井 豊博

  日本呼吸器学会誌, Mar. 2019

  
• 一般人口における経年的肺機能低下と動脈硬化の指標である上腕足首間脈波伝播速度との関連 ながはまスタディ

  濱田 哲; 村瀬 公彦; 田原 康玄; 南 卓馬; 中塚 賀也; 武山 博文; 高橋 順美; 半田 知宏; 平井 豊博; 松田 文彦; 陳 和夫

  日本呼吸器学会誌, Mar. 2019, Peer-reviewed

  
• 環境・喫煙・その他 当院において脳死肺移植登録を行った間質性肺炎の待機予後の検討

  池上 直弥; 半田 知宏; 陳 豊史; 久保 武; 吉澤 明彦; 大角 明宏; 濱路 政嗣; 中島 大輔; 豊 洋次郎; 渡邉 創; 谷澤 公伸; 中塚 賀也; 村瀬 裕子; 中西 智子; 庭本 崇史; 中島 直樹; 陳 和夫; 伊達 洋至; 平井 豊博

  日本呼吸器学会誌, Mar. 2019, Peer-reviewed

  
• 睡眠時無呼吸症候群の病態と治療 住民コホートデータのメタボローム解析でみられた睡眠呼吸障害者の特徴 ながはまスタディ

  中塚 賀也; 村瀬 公彦; 濱田 哲; 武山 博文; 松本 健; 高橋 順美; 谷澤 公伸; 半田 知宏; 田原 康玄; 平井 豊博; 松田 文彦; 陳 和夫

  日本呼吸器学会誌, Mar. 2019, Peer-reviewed

  
• 特発性肺線維症における2型自然リンパ球の意義に関する包括的検討

  中塚 賀也; 半田 知宏; 渡邉 創; 谷澤 公伸; 村瀬 裕子; 池上 直弥; 庭本 崇史; 中西 智子; 陳 和夫; 竹内 理; 平井 豊博

  日本呼吸器学会誌, Mar. 2019, Peer-reviewed

  
• 睡眠時無呼吸症候群の病態と治療 糖尿病家族歴者に睡眠呼吸障害が合併した場合の糖尿病有病率 ながはまスタディ

  南 卓馬; 松本 健; 村瀬 公彦; 谷澤 公伸; 田原 康玄; 武山 博文; 小賀 徹; 長島 俊輔; 若村 智子; 平井 豊博; 松田 文彦; 陳 和夫

  日本呼吸器学会誌, Mar. 2019, Peer-reviewed

  
• Can the Sarcoidosis Health Questionnaire predict the long-term outcomes in Japanese sarcoidosis patients?

  Kiminobu Tanizawa; Tomohiro Handa; Sonoko Nagai; Toru Oga; Takeshi Kubo; Yutaka Ito; Kensaku Aihara; Kohei Ikezoe; Akihiko Sokai; Yoshinari Nakatsuka; Toyohiro Hirai; Kazuo Chin; Michiaki Mishima; Takateru Izumi

  Respiratory medicine, Mar. 2019, Peer-reviewed

  
• Annual decline in arterial blood oxygen predicts development of chronic respiratory failure in COPD with mild hypoxaemia: A 6-year follow-up study.

  Uemasu K; Sato S; Muro S; Sato A; Tanabe N; Hasegawa K; Hamakawa Y; Mizutani T; Fuseya Y; Tanimura K; Takahashi T; Hirai T

  Respirology (Carlton, Vic.), Mar. 2019, Peer-reviewed

  
• Perspectives on End-of-Life Treatment among Patients with COPD: A Multicenter, Cross-sectional Study in Japan.

  Fuseya Y; Muro S; Sato S; Sato A; Tanimura K; Hasegawa K; Uemasu K; Hamakawa Y; Takahashi Y; Nakayama T; Sakai N; Fukui M; Kita H; Mio T; Mishima M; Hirai T

  COPD, Feb. 2019, Peer-reviewed

  
• Adrenal gland size in obstructive sleep apnea: Morphological assessment of hypothalamic pituitary adrenal axis activity.

  Takuma Minami; Ryo Tachikawa; Takeshi Matsumoto; Kimihiko Murase; Kiminobu Tanizawa; Morito Inouchi; Tomohiro Handa; Toru Oga; Toyohiro Hirai; Kazuo Chin

  PloS one, 2019

  
• A Phase II Study of Cisplatin Plus Gemcitabine followed by Maintenance Gemcitabine for Advanced Squamous Non-Small-Cell Lung Cancer: Kyoto Thoracic Oncology Research Group 1302.

  Satoshi Ikeda; Hiroshige Yoshioka; Toshihiko Kaneda; Toshihide Yokoyama; Takashi Niwa; Naoyuki Sone; Tadashi Ishida; Mitsunori Morita; Hiromi Tomioka; Chihito Komaki; Masataka Hirabayashi; Yoshinori Hasegawa; Tetsuo Noguchi; Yasutaka Nakano; Chikara Sakaguchi; Kenichi Yoshimura; Toyohiro Hirai

  Oncology, 2019

  
• Emerging concerns of infectious diseases in lung cancer patients receiving immune checkpoint inhibitor therapy.

  Kohei Fujita; Young Hak Kim; Osamu Kanai; Hironori Yoshida; Tadashi Mio; Toyohiro Hirai

  Respiratory medicine, Jan. 2019, Peer-reviewed

  
• CT Imaging-Based Low-Attenuation Super Clusters in Three Dimensions and the Progression of Emphysema.

  Mondoñedo JR; Sato S; Oguma T; Muro S; Sonnenberg AH; Zeldich D; Parameswaran H; Hirai T; Suki B

  Chest, Jan. 2019, Peer-reviewed

  
• Associations of obstructive sleep apnea with truncal skeletal muscle mass and density

  Takeshi Matsumoto; Kiminobu Tanizawa; Ryo Tachikawa; Kimihiko Murase; Takuma Minami; Morito Inouchi; Tomohiro Handa; Toru Oga; Toyohiro Hirai; Kazuo Chin

  Scientific Reports, 01 Dec. 2018, Peer-reviewed

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• Day-to-Day Home Blood Pressure Variability and Orthostatic Hypotension: The Nagahama Study.

  Yasuharu Tabara; Takeshi Matsumoto; Kimihiko Murase; Kazuya Setoh; Takahisa Kawaguchi; Shunsuke Nagashima; Shinji Kosugi; Takeo Nakayama; Tomoko Wakamura; Toyohiro Hirai; Kazuo Chin; Fumihiko Matsuda

  American journal of hypertension, 13 Nov. 2018, Peer-reviewed

  
• Quantitative measurement of airway dimensions using ultra-high resolution computed tomography.

  Tanabe N; Oguma T; Sato S; Kubo T; Kozawa S; Shima H; Koizumi K; Sato A; Muro S; Togashi K; Hirai T

  Respiratory investigation, Nov. 2018, Peer-reviewed

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• Nocturia and increase in nocturnal blood pressure: the Nagahama study.

  Takeshi Matsumoto; Yasuharu Tabara; Kimihiko Murase; Kazuya Setoh; Takahisa Kawaguchi; Shunsuke Nagashima; Shinji Kosugi; Takeo Nakayama; Tomoko Wakamura; Toyohiro Hirai; Fumihiko Matsuda; Kazuo Chin

  Journal of hypertension, Nov. 2018, Peer-reviewed

  
• Effects of acupuncture on nutritional state of patients with stable chronic obstructive pulmonary disease (COPD): re-analysis of COPD acupuncture trial, a randomized controlled trial.

  Suzuki M; Muro S; Fukui M; Ishizaki N; Sato S; Shiota T; Endo K; Suzuki T; Mitsuma T; Mishima M; Hirai T

  BMC complementary and alternative medicine, Oct. 2018, Peer-reviewed

  
• Serum soluble interleukin-2 receptor as a biomarker in immunoglobulin G4-related disease

  Tomohiro Handa; Shoko Matsui; Hajime Yoshifuji; Yuzo Kodama; Hiroshi Yamamoto; Seijiro Minamoto; Yuko Waseda; Yasuharu Sato; Keishi Kubo; Tsuneyo Mimori; Tsutomu Chiba; Toyohiro Hirai; Michiaki Mishima

  Modern Rheumatology, 03 Sep. 2018, Peer-reviewed

  
• Association between Mycobacterium avium complex lung disease and serum vitamin D status, antimicrobial peptide levels, and bone mineral density.

  Fujita K; Ito Y; Oguma T; Mio T; Niimi A; Hirai T

  Medicine, Sep. 2018, Peer-reviewed

  
• Clinical significance of radiological pleuroparenchymal fibroelastosis pattern in interstitial lung disease patients registered for lung transplantation: a retrospective cohort study.

  Kiminobu Tanizawa; Tomohiro Handa; Takeshi Kubo; Toyofumi F Chen-Yoshikawa; Akihiro Aoyama; Hideki Motoyama; Kyoko Hijiya; Akihiko Yoshizawa; Yohei Oshima; Kohei Ikezoe; Shinsaku Tokuda; Yoshinari Nakatsuka; Yuko Murase; Sonoko Nagai; Shigeo Muro; Toru Oga; Kazuo Chin; Toyohiro Hirai; Hiroshi Date

  Respiratory research, 30 Aug. 2018, Peer-reviewed

  
• Alectinib Resistance in ALK-rearranged Lung Cancer by Dual Salvage Signaling in a Clinically Paired Resistance Model

  Takahiro Tsuji; Hiroaki Ozasa; Wataru Aoki; Shunsuke Aburaya; Tomoko Funazo; Koh Furugaki; Yasushi Yoshimura; Hitomi Ajimizu; Ryoko Okutani; Yuto Yasuda; Takashi Nomizo; Kiyoshi Uemasu; Koichi Hasegawa; Hironori Yoshida; Yoshitaka Yagi; Hiroki Nagai; Yuichi Sakamori; Mitsuyoshi Ueda; Toyohiro Hirai; Young Hak Kim

  Molecular Cancer Research, Aug. 2018, Peer-reviewed

  
• Fractal analysis of low attenuation clusters on computed tomography in chronic obstructive pulmonary disease.

  Tanabe N; Muro S; Sato S; Oguma T; Sato A; Hirai T

  BMC pulmonary medicine, Aug. 2018, Peer-reviewed

  
• Pulmonary Regnase-1 orchestrates the interplay of epithelium and adaptive immune systems to protect against pneumonia.

  Yoshinari Nakatsuka; Alexis Vandenbon; Takashi Mino; Masanori Yoshinaga; Takuya Uehata; Xiaotong Cui; Ayuko Sato; Tohru Tsujimura; Yutaka Suzuki; Atsuyasu Sato; Tomohiro Handa; Kazuo Chin; Teiji Sawa; Toyohiro Hirai; Osamu Takeuchi

  Mucosal immunology, Jul. 2018, Peer-reviewed

  
• Impact of sleep characteristics and obesity on diabetes and hypertension across genders and menopausal status: the Nagahama study.

  Takeshi Matsumoto; Kimihiko Murase; Yasuharu Tabara; David Gozal; Dale Smith; Takuma Minami; Ryo Tachikawa; Kiminobu Tanizawa; Toru Oga; Shunsuke Nagashima; Tomoko Wakamura; Naoko Komenami; Kazuya Setoh; Takahisa Kawaguchi; Takanobu Tsutsumi; Yoshimitsu Takahashi; Takeo Nakayama; Toyohiro Hirai; Fumihiko Matsuda; Kazuo Chin

  Sleep, 01 Jul. 2018, Peer-reviewed

  
• Efficacy and safety of nivolumab in non-small cell lung cancer with preexisting interstitial lung disease.

  Osamu Kanai; Young Hak Kim; Yoshiki Demura; Makiko Kanai; Tsuyoshi Ito; Kohei Fujita; Hironori Yoshida; Masaya Akai; Tadashi Mio; Toyohiro Hirai

  Thoracic cancer, Jul. 2018, Peer-reviewed

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• Xolair導入後の血清総IgEなどの推移

  森本 千絵; 松本 久子; 田尻 智子; 鈴川 真穂; 出原 裕美; 権 寧博; 伊藤 玲子; 橋本 修; 出原 賢治; 太田 昭一郎; 小野 純也; 大田 健; 金光 禎寛; 長崎 忠雄; 小熊 毅; 伊藤 功朗; 新実 彰男; 平井 豊博

  アレルギー, May 2018

  
• 喘息・咳喘息におけるチオトロピウムの有効性に関与する因子の検討

  森本 千絵; 小熊 毅; 石山 裕美; 砂留 広伸; 長崎 忠雄; 伊藤 功朗; 松本 久子; 平井 豊博

  アレルギー, May 2018

  
• 一般人口における喫煙とIgEが好酸球数に及ぼす影響 ながはま疫学研究

  砂留 広伸; 松本 久子; 出原 裕美; 長崎 忠雄; 金光 禎寛; 石山 祐美; 森本 千絵; 小熊 毅; 伊藤 功朗; 室 繁郎; 陳 和夫; 平井 豊博

  アレルギー, May 2018

  
• Efficacy and safety of nivolumab in previously treated patients with non-small cell lung cancer: A multicenter retrospective cohort study

  Daichi Fujimoto; Hiroshige Yoshioka; Yuki Kataoka; Takeshi Morimoto; Young Hak Kim; Keisuke Tomii; Tadashi Ishida; Masataka Hirabayashi; Satoshi Hara; Manabu Ishitoko; Yasushi Fukuda; Moon Hee Hwang; Naoki Sakai; Motonari Fukui; Hitoshi Nakaji; Mitsunori Morita; Tadashi Mio; Takehiro Yasuda; Takakazu Sugita; Toyohiro Hirai

  Lung Cancer, 01 May 2018, Peer-reviewed

  
• Health-related quality of life measurement in patients with chronic respiratory failure

  Toru Oga; Wolfram Windisch; Tomohiro Handa; Toyohiro Hirai; Kazuo Chin

  Respiratory Investigation, 01 May 2018, Peer-reviewed

  
• Gastroesophageal reflux symptoms and nasal symptoms affect the severity of bronchitis symptoms in patients with chronic obstructive pulmonary disease.

  Koichi Hasegawa; Susumu Sato; Kazuya Tanimura; Yoshinori Fuseya; Kiyoshi Uemasu; Yoko Hamakawa; Atsuyasu Sato; Michiaki Mishima; Shigeo Muro; Toyohiro Hirai

  Respiratory investigation, May 2018, Peer-reviewed

  
• 喘息におけるチオトロピウムの有効性に関与する因子の検討

  森本 千絵; 小熊 毅; 石山 祐美; 砂留 広伸; 長崎 忠雄; 松本 久子; 平井 豊博

  日本呼吸器学会誌, Mar. 2018

  
• iPS細胞由来の増殖可能な肺胞上皮II型細胞を含むヒトの発生中肺胞モデル(A Model of Human Developing Alveoli Involving Expandable Alveolar Epithelial Type II cells Derived from iPS Cells)

  Yamamoto Yuki; Gotoh Shimpei; Korogi Yohei; Seki Masahide; Konishi Satoshi; Ikeo Satoshi; Sone Naoyuki; Nagasaki Tadao; Matsumoto Hisako; Muro Shigeo; Ito Isao; Hirai Toyohiro; Kohno Takashi; Suzuki Yutaka; Mishima Michiaki

  日本呼吸器学会誌, Mar. 2018

  
• 遠隔モニタリングシステム導入によるCPAPアドヒアランスの変化 多施設共同無作為化比較試験

  村瀬 公彦; 谷澤 公伸; 津田 徹; 大井 元晴; 赤星 俊樹; 成井 浩司; 名嘉村 博; 大平 徹郎; 吉嶺 裕之; 坪井 知正; 山城 義広; 安藤 眞一; 葛西 隆敏; 北 英夫; 巽 浩一郎; 鰤岡 直人; 富井 啓介; 近藤 康博; 小賀 徹; 酒巻 哲夫; 森田 智視; 平井 豊博; 黒田 知宏; 陳 和夫; 厚生労働科学研究遠隔モニタリング研究班

  日本呼吸器学会誌, Mar. 2018, Peer-reviewed

  
• Nivolumab in non-small-cell lung cancer with EGFR mutation

  H. Yoshida; Y.H. Kim; H. Ozasa; H. Nagai; Y. Sakamori; T. Tsuji; T. Nomizo; Y. Yasuda; T. Funazo; T. Hirai

  Annals of Oncology, Mar. 2018, Peer-reviewed

  
• 一般人口における喫煙とIgEが好酸球数に及ぼす影響 ながはま疫学研究

  砂留 広伸; 松本 久子; 出原 裕美; 長崎 忠雄; 金光 禎寛; 石山 祐美; 森本 千絵; 小熊 毅; 伊藤 功朗; 田原 康玄; 室 繁郎; 陳 和夫; 平井 豊博

  日本呼吸器学会誌, Mar. 2018

  
• Seasonal variation in nocturnal home blood pressure fall: the Nagahama study.

  Yasuharu Tabara; Takeshi Matsumoto; Kimihiko Murase; Shunsuke Nagashima; Toyohiro Hirai; Shinji Kosugi; Takeo Nakayama; Tomoko Wakamura; Kazuo Chin; Fumihiko Matsuda

  Hypertension research : official journal of the Japanese Society of Hypertension, Mar. 2018, Peer-reviewed

  
• Impact of long-term continuous positive airway pressure on liver fat in male obstructive sleep apnea patients with fatty liver

  Yoshiro Toyama; Kimihiko Murase; Masanori Azuma; Satoshi Hamada; Ryo Tachikawa; Kiminobu Tanizawa; Tomohiro Handa; Takeshi Kubo; Takefumi Hitomi; Toru Oga; Toyohiro Hirai; Kazuo Chin

  Sleep and Biological Rhythms, 01 Jan. 2018, Peer-reviewed

  
• Efficacy of Ceritinib After Alectinib for ALK-positive Non-small Cell Lung Cancer

  HIRONORI YOSHIDA; YOUNG HAK KIM; HIROAKI OZASA; YUICHI SAKAMORI; TAKAHIRO TSUJI; TAKASHI NOMIZO; YUTO YASUDA; TOMOKO YAMAMOTO; HITOMI AJIMIZU; TOYOHIRO HIRAI

  In Vivo, 2018, Peer-reviewed

  
• The Clinical Significance of Body Weight Loss in Idiopathic Pulmonary Fibrosis Patients.

  Nakatsuka Y; Handa T; Kokosi M; Tanizawa K; Puglisi S; Jacob J; Sokai A; Ikezoe K; Kanatani KT; Kubo T; Tomioka H; Taguchi Y; Nagai S; Chin K; Mishima M; Wells AU; Hirai T

  Respiration; international review of thoracic diseases, 2018, Peer-reviewed

  
• CT-Based Low-Attenuation Super Clusters in 3D and the Progression of Emphysema.

  Mondoñedo JR; Sato S; Oguma T; Muro S; Sonnenberg AH; Zeldich D; Parameswaran H; Hirai T; Suki B

  Chest., 2018, Peer-reviewed

  
• Pseudoprogression in previously treated patients with non-small cell lung cancer who received nivolumab monotherapy: A multicenter retrospective cohort study.

  Fujimoto D; Yoshioka H; Kataoka Y; Morimoto T; Hata T; Kim YH; Tomii K; Ishida T; Hirabayashi M; Hara S; Ishitoko M; Fukuda Y; Hwang MH; Sakai N; Fukui M; Nakaji H; Morita M; Mio T; Yasuda T; Sugita T; Hirai T

  J Thorac Oncol, 2018, Peer-reviewed

  
• Complementary regional heterogeneity information from COPD patients obtained using oxygen-enhanced MRI and chest CT.

  Yoshinori Fuseya; Shigeo Muro; Susumu Sato; Naoya Tanabe; Atsuyasu Sato; Kazuya Tanimura; Koichi Hasegawa; Kiyoshi Uemasu; Takeshi Kubo; Aki Kido; Koji Fujimoto; Yasutaka Fushimi; Hiroshi Kusahara; Naotaka Sakashita; Yoshiharu Ohno; Kaori Togashi; Michiaki Mishima; Toyohiro Hirai

  PloS one, 2018, Peer-reviewed

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• Progressive restrictive ventilatory impairment in idiopathic diffuse pulmonary ossification

  Hidemasa Matsuo; Tomohiro Handa; Michiko Tsuchiya; Takeshi Kubo; Akihiko Yoshizawa; Yuko Nakayama; Shuichi Shiga; Takefumi Hitomi; Souichi Adachi; Hiroshi Date; Toyohiro Hirai; Satoshi Ichiyama

  Internal Medicine, 2018, Peer-reviewed

  
• オルガノイド形成下におけるヒトiPS細胞由来肺胞幹細胞の長期培養とその細胞不均一性

  山本 佑樹; 後藤 慎平; 興梠 陽平; 関 真秀; 小西 聡史; 池尾 聡; 曽根 尚之; 長崎 忠雄; 松本 久子; 室 繁郎; 伊藤 功朗; 平井 豊博; 河野 隆志; 鈴木 穣; 三嶋 理晃

  生命科学系学会合同年次大会, Dec. 2017

  
• Difference of the progression of pulmonary cysts assessed by computed tomography among COPD, lymphangioleiomyomatosis, and Birt-Hogg-Dube A syndrome

  Kazunori Tobino; Toyohiro Hirai; Takeshi Johkoh; Kiminori Fujimoto; Atsushi Kawaguchi; Noriyuki Tomiyama; Kazuhisa Takahashi; Kuniaki Seyama

  PLOS ONE, Dec. 2017, Peer-reviewed

  
• Long-term expansion of alveolar stem cells derived from human iPS cells in organoids

  Yuki Yamamoto; Shimpei Gotoh; Yohei Korogi; Masahide Seki; Satoshi Konishi; Satoshi Ikeo; Naoyuki Sone; Tadao Nagasaki; Hisako Matsumoto; Shigeo Muro; Isao Ito; Toyohiro Hirai; Takashi Kohno; Yutaka Suzuki; Michiaki Mishima

  NATURE METHODS, Nov. 2017, Peer-reviewed

  
• Sensitization to &ITStaphylococcus aureus&IT enterotoxins in smokers with asthma

  Tadao Nagasaki; Hisako Matsumoto; Tsuyoshi Oguma; Isao Ito; Hideki Inoue; Toshiyuki Iwata; Tomoko Tajiri; Yoshihiro Kanemitsu; Yumi Izuhara; Chie Morimoto; Yumi Ishiyama; Hironobu Sunadome; Akio Niimi; Toyohiro Hirai

  ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, Nov. 2017, Peer-reviewed

  
• Risk factors for stomatitis in patients with lymphangioleiomyomatosis during treatment with sirolimus: A multicenter investigator-initiated prospective study

  Nobutaka Kitamura; Kuniaki Seyama; Yoshikazu Inoue; Katsura Nagai; Masaru Suzuki; Hiroshi Moriyama; Toshinori Takada; Ryushi Tazawa; Toyohiro Hirai; Michiaki Mishima; Mie Hayashida; Masaki Hirose; Toru Arai; Chikatoshi Sugimoto; Noboru Hattori; Kentaro Watanabe; Tsutomu Tamada; Kohei Akazawa; Takahiro Tanaka; Koh Nakata

  PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, Oct. 2017, Peer-reviewed

  
• Clinical impact of high serum hepatocyte growth factor in advanced non-small cell lung cancer

  Takahiro Tsuji; Yuichi Sakamori; Hiroaki Ozasa; Yoshitaka Yagi; Hitomi Ajimizu; Yuto Yasuda; Tomoko Funazo; Takashi Nomizo; Hironori Yoshida; Hiroki Nagai; Ken Maeno; Tetsuya Oguri; Toyohiro Hirai; Young Hak Kim

  ONCOTARGET, Sep. 2017, Peer-reviewed

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• Fraction of MHCII and EpCAM expression characterizes distal lung epithelial cells for alveolar type 2 cell isolation.

  Koichi Hasegawa; Atsuyasu Sato; Kazuya Tanimura; Kiyoshi Uemasu; Yoko Hamakawa; Yoshinori Fuseya; Susumu Sato; Shigeo Muro; Toyohiro Hirai

  Respiratory research, 07 Aug. 2017, Peer-reviewed

  
• Fraction of MHCII and EpCAM expression characterizes distal lung epithelial cells for alveolar type 2 cell isolation

  Koichi Hasegawa; Atsuyasu Sato; Kazuya Tanimura; Kiyoshi Uemasu; Yoko Hamakawa; Yoshinori Fuseya; Susumu Sato; Shigeo Muro; Toyohiro Hirai

  RESPIRATORY RESEARCH, Aug. 2017, Peer-reviewed

  
• Claudin-4 knockout by TALEN-mediated gene targeting in MDCK cells: Claudin-4 is dispensable for the permeability properties of tight junctions in wild-type MDCK cells

  Shinsaku Tokuda; Toyohiro Hirai; Mikio Furuse

  PLOS ONE, Aug. 2017, Peer-reviewed

  
• Successful oral desensitization with crizotinib after crizotinib-induced hepatitis in an anaplastic lymphoma kinase-rearranged non-small-cell lung cancer patient: A case report.

  Yuto Yasuda; Yasuyo Nishikawa; Yuichi Sakamori; Makoto Terao; Kentaro Hashimoto; Tomoko Funazo; Takashi Nomizo; Takahiro Tsuji; Hironori Yoshida; Hiroki Nagai; Hiroaki Ozasa; Toyohiro Hirai; Young Hak Kim

  Molecular and clinical oncology, Aug. 2017, Peer-reviewed

  
• Prognostic factors and outcomes in Japanese lung transplant candidates with interstitial lung disease

  Kohei Ikezoe; Tomohiro Handa; Kiminobu Tanizawa; Toyofumi F. Chen-Yoshikawa; Takeshi Kubo; Akihiro Aoyama; Hideki Motoyama; Kyoko Hijiya; Shinsaku Tokuda; Yoshinari Nakatsuka; Yuko Yamamoto; Ayako Oshima; Shin-ichi Harashima; Sonoko Nagai; Toyohiro Hirai; Hiroshi Date; Kazuo Chin

  PLOS ONE, Aug. 2017, Peer-reviewed

  
• Importance of serial changes in biomarkers in idiopathic pulmonary fibrosis.

  Akihiko Sokai; Kiminobu Tanizawa; Tomohiro Handa; Kumiko Kanatani; Takeshi Kubo; Kohei Ikezoe; Yoshinari Nakatsuka; Shinsaku Tokuda; Toru Oga; Toyohiro Hirai; Sonoko Nagai; Kazuo Chin; Michiaki Mishima

  ERJ open research, Jul. 2017, Peer-reviewed

  
• 一般人口における末梢血好酸球数とBMI、遺伝子多型との関係 ながはま疫学研究

  砂留 広伸; 松本 久子; 長崎 忠雄; 金光 禎寛; 小熊 毅; 伊藤 功朗; 田原 康玄; 室 繁郎; 陳 和夫; 平井 豊博

  日本職業・環境アレルギー学会雑誌, Jun. 2017

  
• The long-term outcome of interstitial lung disease with antiaminoacyl-tRNA synthetase antibodies

  Kiminobu Tanizawa; Tomohiro Handa; Ran Nakashima; Takeshi Kubo; Yuji Hosono; Kizuku Watanabe; Kensaku Aihara; Kohei Ikezoe; Akihiko Sokai; Yoshinari Nakatsuka; Yoshio Taguchi; Kazuhiro Hatta; Satoshi Noma; Yoichiro Kobashi; Akihiko Yoshizawa; Toru Oga; Toyohiro Hirai; Kazuo Chin; Sonoko Nagai; Takateru Izumi; Tsuneyo Mimori; Michiaki Mishima

  RESPIRATORY MEDICINE, Jun. 2017, Peer-reviewed

  
• EGFR T790M Detection in Circulating Tumor DNA from Non-small Cell Lung Cancer Patients Using the PNA-LNA Clamp Method

  Hironori Yoshida; Young Hak Kim; Hiroaki Ozasa; Hiroki Nagai; Yuichi Sakamori; Takahiro Tsuji; Takashi Nomizo; Tomoko Funazo; Yuto Yasuda; Toyohiro Hirai

  ANTICANCER RESEARCH, May 2017, Peer-reviewed

  
• Asymmetry in acute exacerbation of idiopathic pulmonary fibrosis.

  Akihiko Sokai; Kiminobu Tanizawa; Tomohiro Handa; Takeshi Kubo; Seishu Hashimoto; Kohei Ikezoe; Yoshinari Nakatsuka; Kensaku Aihara; Yoshio Taguchi; Shigeo Muro; Toru Oga; Sonoko Nagai; Takateru Izumi; Toyohiro Hirai; Kazuo Chin; Michiaki Mishima

  ERJ open research, Apr. 2017, Peer-reviewed

  
• Clinical Impact of Single Nucleotide Polymorphism in PD-L1 on Response to Nivolumab for Advanced Non-Small-Cell Lung Cancer Patients.

  Takashi Nomizo; Hiroaki Ozasa; Takahiro Tsuji; Tomoko Funazo; Yuto Yasuda; Hironori Yoshida; Yoshitaka Yagi; Yuichi Sakamori; Hiroki Nagai; Toyohiro Hirai; Young Hak Kim

  Scientific reports, 23 Mar. 2017, Peer-reviewed

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• COPD 併存症 頻回増悪と全身炎症は抗重力筋萎縮に寄与する 胸部CTを用いた定量的縦断解析

  谷村 和哉; 佐藤 晋; 佐藤 篤靖; 長谷川 浩一; 上桝 潔; 濱川 瑶子; 小熊 毅; 平井 豊博; 加藤 元一; 室 繁郎

  日本呼吸器学会誌, Mar. 2017

  
• 胸部CT画像から得られるCOPDの予後因子の比較 気腫病変と併存病態

  佐藤 晋; 谷村 和哉; 佐藤 篤靖; 長谷川 浩一; 上桝 潔; 濱川 瑶子; 小熊 毅; 平井 豊博; 室 繁郎

  日本呼吸器学会誌, Mar. 2017

  
• Comprehensive evaluation of airway involvement in pulmonary sarcoidosis

  Kiminobu Tanizawa; Tomohiro Handa; Sonoko Nagai; Akio Niimi; Tsuyoshi Oguma; Takeshi Kubo; Yutaka Ito; Kensaku Aihara; Kohei Ikezoe; Hisako Matsumoto; Toyohiro Hirai; Kazuo Chin; Michiaki Mishima

  ERJ Open Research, 01 Jan. 2017, Peer-reviewed

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• Chronic Kidney Disease Predicts Survival in Patients with Idiopathic Pulmonary Fibrosis

  Kohei Ikezoe; Tomohiro Handa; Kiminobu Tanizawa; Hideki Yokoi; Takeshi Kubo; Kensaku Aihara; Akihiko Sokai; Yoshinari Nakatsuka; Seishu Hashimoto; Kiyoshi Uemasu; Susumu Sato; Shigeo Muro; Sonoko Nagai; Motoko Yanagita; Kazuo Chin; Toyohiro Hirai; Yoshio Taguchi; Michiaki Mishima

  RESPIRATION, 2017, Peer-reviewed

  
• Efficacy and safety of long-term sirolimus therapy for asian patients with lymphangioleiomyomatosis

  Toshinori Takada; Ayako Mikami; Nobutaka Kitamura; Kuniaki Seyama; Yoshikazu Inoue; Katsura Nagai; Masaru Suzuki; Hiroshi Moriyama; Keiichi Akasaka; Ryushi Tazawa; Toyohiro Hirai; Michiaki Mishima; Mie Hayashida; Masaki Hirose; Chikatoshi Sugimoto; Toru Arai; Noboru Hattori; Kentaro Watanabe; Tsutomu Tamada; Hirohisa Yoshizawa; Kohei Akazawa; Takahiro Tanaka; Keita Yagi; Lisa R. Young; Francis X. McCormack; Koh Nakata

  Annals of the American Thoracic Society, 01 Nov. 2016, Peer-reviewed

  
• Efficacy and Safety of Long-Term Sirolimus Therapy for Asian Patients with Lymphangioleiomyomatosis

  Takada, Toshinori; Mikami, Ayako; Kitamura, Nobutaka; Seyama, Kuniaki; Inoue, Yoshikazu; Nagai, Katsura; Suzuki, Masaru; Moriyama, Hiroshi; Akasaka, Keiichi; Tazawa, Ryushi; Hirai, Toyohiro; Mishima, Michiaki; Hayashida, Mie; Hirose, Masaki; Sugimoto, Chikatoshi; Arai, Toru; Hattori, Noboru; Watanabe, Kentaro; Tamada, Tsutomu; Yoshizawa, Hirohisa; Akazawa, Kohei; Tanaka, Takahiro; Yagi, Keita; Young, Lisa R; McCormack; Francis X; Nakata, Koh

  ANNALS OF THE AMERICAN THORACIC SOCIETY, Nov. 2016, Peer-reviewed

  
• Efficacy and Safety of Long-Term Sirolimus Therapy for Asian Patients with Lymphangioleiomyomatosis.

  Takada T; Mikami A; Kitamura N; Seyama K; Inoue Y; Nagai K; Suzuki M; Moriyama H; Akasaka K; Tazawa R; Hirai T; Mishima M; Hayashida M; Hirose M; Sugimoto C; Arai T; Hattori N; Watanabe K; Tamada T; Yoshizawa H; Akazawa K; Tanaka T; Yagi K; Young LR; McCormack FX; Nakata K

  Annals of the American Thoracic Society, Nov. 2016, Peer-reviewed

  
• Effects of Osmolality on Paracellular Transport in MDCK II Cells

  Shinsaku Tokuda; Toyohiro Hirai; Mikio Furuse

  PLOS ONE, Nov. 2016, Peer-reviewed

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• Impact of industrial structure and soil exposure on the regional variations in pulmonary nontuberculous mycobacterial disease prevalence.

  Hamada S; Ito Y; Hirai T; Murase K; Tsuji T; Fujita K; Mio T; Maekawa K; Fujii T; Ono S; Nishimura T; Hayashi A; Komori T; Fujita N; Niimi A; Ichiyama S; Chin K; Mishima M

  International journal of mycobacteriology, Jun. 2016, Peer-reviewed

  
• Risk factors for nosocomial tuberculosis transmission among health care workers

  Yutaka Ito; Miki Nagao; Yoshitsugu Iinuma; Yasufumi Matsumura; Masaki Yamamoto; Shunji Takakura; Junko Igawa; Hiroe Yamanaka; Akiko Hashimoto; Toyohiro Hirai; Akio Niimi; Satoshi Ichiyama; Michiaki Mishima

  AMERICAN JOURNAL OF INFECTION CONTROL, May 2016, Peer-reviewed

  
• A nationwide epidemiological survey of alpha1-antitrypsin deficiency in Japan

  Kuniaki Seyama; The Respiratory Failure Research Group of the Japanese Ministry of Health, Labour, and Welfare; Toyohiro Hirai; Michiaki Mishima; Koichiro Tatsumi; Masaharu Nishimura

  Respiratory Investigation, 01 May 2016, Peer-reviewed

  
• [α1-Antitrypsin deficiency].

  Hirai T

  Nihon rinsho. Japanese journal of clinical medicine, May 2016, Peer-reviewed

  
• Serial perfusion in native lungs in patients with idiopathic pulmonary fibrosis and other interstitial lung diseases after single lung transplantation

  Akihiko Sokai; Tomohiro Handa; Fengshi Chen; Kiminobu Tanizawa; Akihiro Aoyama; Takeshi Kubo; Kohei Ikezoe; Yoshinari Nakatsuka; Tsuyoshi Oguma; Toyohiro Hirai; Sonoko Nagai; Kazuo Chin; Hiroshi Date; Michiaki Mishima

  CLINICAL TRANSPLANTATION, Apr. 2016, Peer-reviewed

  
• Quantitative assessment of erector spinae muscles in patients with chronic obstructive pulmonary disease novel chest computed tomography-derived index for prognosis

  Kazuya Tanimura; Susumu Sato; Yoshinori Fuseya; Koichi Hasegawa; Kiyoshi Uemasu; Atsuyasu Sato; Tsuyoshi Oguma; Toyohiro Hirai; Michiaki Mishima; Shigeo Muro

  Annals of the American Thoracic Society, 01 Mar. 2016, Peer-reviewed

  
• COPD患者における呼吸器関連イベント発生の予測に関する検討

  上桝 潔; 佐藤 晋; 佐藤篤靖; 谷村和哉; 長谷川浩一; 濱川瑶子; 平井豊博; 三嶋理晃; 室 繁郎

  日本呼吸器学会誌, Mar. 2016

  
• COPD患者のうつ病性障害と関連する因子についての検討

  Youko Hamakawa; Susumu Sato; Atsuyasu Sato; Koichi Hasegawa; Kazuya Tanimura; Kiyoshi Uemasu; Toyohiro Hirai; Michiaki Mishima; Shigeo Muro

  日本呼吸器学会誌, Mar. 2016

  
• 胸部CTから読み取るCOPD患者の新たな予後予測因子—抗重力筋評価の意義

  Kazuya Tanimura; Susumu Sato; Atsuyasu Sato; Yohei Oshima; Koichi Hasegawa; Kiyoshi Uemasu; Youko Hamakawa; Tsuyoshi Oguma; Toyohiro Hirai; Shigeo Muro; Michiaki Mishima

  日本呼吸器学会誌, Mar. 2016

  
• ヒトiPS細胞から機能的な気道線毛上皮細胞への分化誘導

  Satoshi Konishi; Shimpei Goto; Kazuhiro Tateishi; Yuki Yamamoto; Yohei Korogi; Tadao Nagasaki; Hisako Matsumoto; Shigeo Muro; Toyohiro Hirai; Isao Ito; Sachiko Tsukita; Michiaki Mishima

  日本呼吸器学会誌, Mar. 2016

  
• Quantitative Assessment of Erector Spinae Muscles in Patients with Chronic Obstructive Pulmonary Disease. Novel Chest Computed Tomography-derived Index for Prognosis.

  Tanimura K; Sato S; Fuseya Y; Hasegawa K; Uemasu K; Sato A; Oguma T; Hirai T; Mishima M; Muro S

  Annals of the American Thoracic Society, Mar. 2016, Peer-reviewed

  
• Preliminary evaluation of a sitafloxacin-containing regimen for relapsed or refractory pulmonary Mycobacterium Avium complex disease

  Kohei Fujita; Masaki Fujita; Yutaka Ito; Toyohiro Hirai; Tadashi Mio; Kentaro Watanabe; Michiaki Mishima

  Open Forum Infectious Diseases, 2016, Peer-reviewed

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• Evaluation of bone mineral density by computed tomography in patients with obstructive sleep apnea

  Satoshi Hamada; Kohei Ikezoe; Toyohiro Hirai; Tsuyoshi Oguma; Kiminobu Tanizawa; Morito Inouchi; Tomohiro Handa; Toru Oga; Michiaki Mishima; Kazuo Chin

  Journal of Clinical Sleep Medicine, 2016, Peer-reviewed

  
• 特発性肺線維症におけるKL-6の変化の臨床的意義

  祖開 暁彦; 谷澤 公伸; 半田 知宏; 池添 浩平; 中塚 賀也; 久保 武; 小賀 徹; 平井 豊博; 長井 苑子; 陳 和夫; 三嶋 理晃

  日本呼吸器学会誌, 2016

  
• 特発性肺線維症に特異的な健康状態質問票(SGRQ-I)の有用性の検討

  祖開 暁彦; 半田 知宏; 小賀 徹; 谷澤 公伸; 池添 浩平; 中塚 賀也; 久保 武; 平井 豊博; 長井 苑子; 陳 和夫; 三嶋 理晃

  日本呼吸器学会誌, 2016

  
• 間質性肺炎・肺線維症の疫学 特発性肺線維症患者における慢性腎臓病と予後の関連

  池添 浩平; 半田 知宏; 谷澤 公伸; 祖開 暁彦; 中塚 賀也; 久保 武; 平井 豊博; 田口 善夫; 長井 苑子; 陳 和夫; 三嶋 理晃

  日本呼吸器学会誌, 2016

  
• Three-Dimensional Lobar Evaluation of Pharmacological Volume Reduction Induced by Tiotropium in COPD Patients.

  S.Sato; S. Muro; K. Tanimura; T. Oguma; A. Sato; K. Hasegawa; K. Uemasu; Y. Hamakawa; T. Hirai; M. Mishima

  American Thoracic Society International Conference, 2016

  
• Association of COPD exacerbation frequency with gene expression of pattern recognition receptors in inflammatory cells in induced sputum

  Daisuke Kinose; Emiko Ogawa; Megumi Kudo; Satoshi Marumo; Hirofumi Kiyokawa; Yuma Hoshino; Toyohiro Hirai; Kazuo Chin; Shigeo Muro; Michiaki Mishima

  CLINICAL RESPIRATORY JOURNAL, Jan. 2016, Peer-reviewed

  
• Directed Induction of Functional Multi-ciliated Cells in Proximal Airway Epithelial Spheroids from Human Pluripotent Stem Cells

  Satoshi Konishi; Shimpei Gotoh; Kazuhiro Tateishi; Yuki Yamamoto; Yohei Korogi; Tadao Nagasaki; Hisako Matsumoto; Shigeo Muro; Toyohiro Hirai; Isao Ito; Sachiko Tsukita; Michiaki Mishima

  STEM CELL REPORTS, Jan. 2016, Peer-reviewed

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• Lung Transplantation for Lymphangioleiomyomatosis in Japan

  Katsutoshi Ando; Yoshinori Okada; Miki Akiba; Takashi Kondo; Tomohiro Kawamura; Meinoshin Okumura; Fengshi Chen; Hiroshi Date; Takeshi Shiraishi; Akinori Iwasaki; Naoya Yamasaki; Takeshi Nagayasu; Masayuki Chida; Yoshikazu Inoue; Toyohiro Hirai; Kuniaki Seyama; Michiaki Mishima

  PLOS ONE, Jan. 2016, Peer-reviewed

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• PLATELET AGGREGABILITY IN PATIENTS WITH INTERSTITIAL PNEUMONIAS

  Tomohiro Handa; Kizuku Watanabe; Kiminobu Tanizawa; Toru Oga; Kensaku Aihara; Kohei Ikezoe; Akihiko Sokai; Yoshinari Nakatsuka; Toyohiro Hirai; Sonoko Nagai; Kazuo Chin; Hisanori Horiuchi; Michiaki Mishima

  SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES, 2016, Peer-reviewed

  
• [Osteoporosis in chronic obstructive pulmonary disease.]

  Hirai T

  Clinical calcium, 2016, Peer-reviewed

  
• Preliminary Evaluation Of A Sitafloxacin - Containing Regimen For Relapsed Or Refractory Pulmonary Mycobacterium Avium Complex Disease

  K. Fujita; M. Fujita; Y. Ito; T. Hirai; T. Mio; K. Watanabe; M. Mishima

  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2016, Peer-reviewed

  
• ヒトiPS細胞から気道線毛上皮細胞への分化誘導

  小西 聡史; 後藤 慎平; 立石 和博; 山本 佑樹; 興梠 陽平; 長崎 忠雄; 松本 久子; 室 繁郎; 平井 豊博; 伊藤 功朗; 月田 早智子; 三嶋 理晃

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015

  
• Effects of Hydrostatic Pressure on Carcinogenic Properties of Epithelia

  Shinsaku Tokuda; Young Hak Kim; Hisako Matsumoto; Shigeo Muro; Toyohiro Hirai; Michiaki Mishima; Mikio Furuse

  PLOS ONE, Dec. 2015, Peer-reviewed

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• Matrix metalloproteinase-10: a novel biomarker for idiopathic pulmonary fibrosis.

  Akihiko Sokai; Tomohiro Handa; Kiminobu Tanizawa; Toru Oga; Kazuko Uno; Tatsuaki Tsuruyama; Takeshi Kubo; Kohei Ikezoe; Yoshinari Nakatsuka; Kazuya Tanimura; Shigeo Muro; Toyohiro Hirai; Sonoko Nagai; Kazuo Chin; Michiaki Mishima

  Respiratory research, 29 Sep. 2015, Peer-reviewed

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• 胸部CTから読み取るCOPD患者の新たな臨床指標 抗重力筋評価の重要性

  谷村 和哉; 佐藤 晋; 佐藤 篤靖; 大島 洋平; 長谷川 浩一; 小熊 毅; 長谷川 聡; 平井 豊博; 三嶋 理晃; 室 繁郎

  日本呼吸ケア・リハビリテーション学会誌, Sep. 2015

  
• Bone mineral density in patients with idiopathic pulmonary fibrosis.

  Kohei Ikezoe; Tomohiro Handa; Kiminobu Tanizawa; Takeshi Kubo; Tsuyoshi Oguma; Satoshi Hamada; Kizuku Watanabe; Kensaku Aihara; Akihiko Sokai; Yoshinari Nakatsuka; Shigeo Muro; Sonoko Nagai; Kazuko Uno; Kazuo Chin; Motonari Fukui; Toyohiro Hirai; Michiaki Mishima

  Respiratory medicine, Sep. 2015, Peer-reviewed

  
• Longitudinal shape irregularity of airway lumen assessed by CT in patients with bronchial asthma and COPD

  Tsuyoshi Oguma; Toyohiro Hirai; Motonari Fukui; Naoya Tanabe; Satoshi Marumo; Hajime Nakamura; Hisao Ito; Susumu Sato; Akio Niimi; Isao Ito; Hisako Matsumoto; Shigeo Muro; Michiaki Mishima

  Thorax, 01 Aug. 2015, Peer-reviewed

  
• Clinical impact of high-attenuation and cystic areas on computed tomography in fibrotic idiopathic interstitial pneumonias

  Kiminobu Tanizawa; Tomohiro Handa; Sonoko Nagai; Toyohiro Hirai; Takeshi Kubo; Tsuyoshi Oguma; Isao Ito; Yutaka Ito; Kizuku Watanabe; Kensaku Aihara; Kohei Ikezoe; Toru Oga; Kazuo Chin; Takateru Izumi; Michiaki Mishima

  BMC Pulmonary Medicine, 24 Jul. 2015, Peer-reviewed

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• Assessment of Small Airways with Computed Tomography: Mosaic Attenuation or Lung Density?

  Tsuyoshi Oguma; Akio Niimi; Toyohiro Hirai; Makiko Jinnai; Hisako Matsumoto; Isao Ito; Masafumi Yamaguchi; Hirofumi Matsuoka; Kojiro Otsuka; Tomoshi Takeda; Hitoshi Nakaji; Kazuo Chin; Michiaki Mishima

  Respiration, 22 Jul. 2015, Peer-reviewed

  
• Emphysema and airway disease affect within-breath changes in respiratory resistance in COPD patients

  Koichi Hasegawa; Susumu Sato; Kazuya Tanimura; Yoshinori Fuseya; Kiyoshi Uemasu; Atsuyasu Sato; Toyohiro Hirai; Michiaki Mishima; Shigeo Muro

  Respirology, 01 Jul. 2015, Peer-reviewed

  
• Total lesion glycolysis as an IgG4-related disease activity marker

  Yoshinari Nakatsuka; Tomohiro Handa; Yuji Nakamoto; Tomomi Nobashi; Hajime Yoshihuji; Kiminobu Tanizawa; Kohei Ikezoe; Akihiko Sokai; Takeshi Kubo; Toyohiro Hirai; Kazuo Chin; Kaori Togashi; Tsuneyo Mimori; Michiaki Mishima

  MODERN RHEUMATOLOGY, Jul. 2015, Peer-reviewed

  
• ヒト多能性幹細胞から呼吸器上皮細胞への分化誘導

  後藤 慎平; 小西 聡史; 山本 佑樹; 興梠 陽平; 長崎 忠雄; 松本 久子; 室 繁郎; 平井 豊博; 伊藤 功朗; 三嶋 理晃

  日本細胞生物学会大会講演要旨集, Jun. 2015

  
• 遺伝性呼吸器疾患の疾患特異的iPS細胞樹立

  GOTO SHIMPEI; ITO ISAO; ITO ISAO; KOROGI YOHEI; YAMAMOTO YUKI; KONISHI SATOSHI; NAGASAKI TADAO; MATSUMOTO HISAKO; SATO ATSUYASU; MURO SHIGEO; HIRAI TOYOHIRO; OSAFUNE KENJI; ASAKA ISAO; SEYAMA KUNIAKI; MISHIMA MICHIAKI

  日本呼吸器学会誌, 10 Mar. 2015

  
• ヒトiPS細胞から気道繊毛上皮前駆細胞への効率の良い分化誘導法の確立

  KONISHI SATOSHI; GOTO SHIMPEI; YAMAMOTO YUKI; KOROGI YOHEI; NAGASAKI TADAO; MATSUMOTO HISAKO; MURO SHIGEO; HIRAI TOYOHIRO; ITO ISAO; ITO ISAO; MISHIMA MICHIAKI

  日本呼吸器学会誌, 10 Mar. 2015

  
• 呼吸器疾患における遺伝子発現及び変異 ヒトiPS細胞から2型肺胞上皮細胞への分化誘導効率の改善

  山本 佑樹; 後藤 慎平; 興梠 陽平; 小西 聡史; 長崎 忠雄; 松本 久子; 室 繁郎; 平井 豊博; 伊藤 功朗; 三嶋 理晃

  日本呼吸器学会誌, Mar. 2015

  
• 間質性肺炎に対する脳死片肺移植後残存肺の換気/血流の経時変化

  祖開 暁彦; 半田 知宏; 陳 豊史; 谷澤 公伸; 志熊 啓; 大畑 惠資; 久保 武; 池添 浩平; 中塚 賀也; 小熊 毅; 平井 豊博; 長井 苑子; 陳 和夫; 伊達 洋至; 三嶋 理晃

  日本呼吸器学会誌, 2015

  
• 特発性肺線維症における体重減少の意義についての検討

  中塚 賀也; 半田 知宏; 谷澤 公伸; 祖開 暁彦; 池添 浩平; 渡邉 創; 相原 顕作; 久保 武; 田口 善夫; 平井 豊博; 長井 苑子; 陳 和夫; 三嶋 理晃

  日本呼吸器学会誌, 2015

  
• Quantitative Assessment of Skeletal Muscles Mass in COPD Patients Using Chest CT Images

  Tanimura K; Sato S; Sato A; Fuseya Y; Hasegawa K; Uemasu K; Hirai T; Mishima M; Muro S

  American Thoracic Society, 2015

  
• Increasing patients with pulmonary Mycobacterium avium complex disease and associated underlying diseases in Japan

  Yutaka Ito; Toyohiro Hirai; Kohei Fujita; Koichi Maekawa; Akio Niimi; Satoshi Ichiyama; Michiaki Mishima

  Journal of Infection and Chemotherapy, 2015, Peer-reviewed

  
• Comparison of two devices for respiratory impedance measurement using a forced oscillation technique: basic study using phantom models

  Kazuya Tanimura; Toyohiro Hirai; Susumu Sato; Koichi Hasegawa; Shigeo Muro; Hajime Kurosawa; Michiaki Mishima

  JOURNAL OF PHYSIOLOGICAL SCIENCES, Sep. 2014, Peer-reviewed

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• Generation of Alveolar Epithelial Spheroids via Isolated Progenitor Cells from Human Pluripotent Stem Cells

  Shimpei Gotoh; Isao Ito; Tadao Nagasaki; Yuki Yamamoto; Satoshi Konishi; Yohei Korogi; Hisako Matsumoto; Shigeo Muro; Toyohiro Hirai; Michinori Funato; Shin-Ichi Mae; Taro Toyoda; Aiko Sato-Otsubo; Seishi Ogawa; Kenji Osafune; Michiaki Mishima

  STEM CELL REPORTS, Sep. 2014, Peer-reviewed

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• The influence of environmental exposure on the response to antimicrobial treatment in pulmonary Mycobacterial avium complex disease

  Yutaka Ito; Toyohiro Hirai; Kohei Fujita; Takeshi Kubo; Koichi Maekawa; Satoshi Ichiyama; Kaori Togashi; Michiaki Mishima

  BMC INFECTIOUS DISEASES, Sep. 2014, Peer-reviewed

  
• Prevalence and risk factors for chronic co-infection in pulmonary mycobacterium avium complex disease

  Kohei Fujita; Yutaka Ito; Toyohiro Hirai; Takeshi Kubo; Kaori Togashi; Satoshi Ichiyama; Michiaki Mishima

  BMJ Open Respiratory Research, 28 Aug. 2014, Peer-reviewed

  
• Neutrophil gelatinase-associated lipocalin in idiopathic pulmonary fibrosis

  Kohei Ikezoe; Tomohiro Handa; Kiyoshi Mori; Kizuku Watanabe; Kiminobu Tanizawa; Kensaku Aihara; Tatsuaki Tsuruyama; Aya Miyagawa-Hayashino; Akihiko Sokai; Takeshi Kubo; Shigeo Muro; Sonoko Nagai; Toyohiro Hirai; Kazuo Chin; Michiaki Mishima

  EUROPEAN RESPIRATORY JOURNAL, Jun. 2014, Peer-reviewed

  
• p38 mitogen-activated protein kinase determines the susceptibility to cigarette smoke-induced emphysema in mice

  Satoshi Marumo; Yuma Hoshino; Hirofumi Kiyokawa; Naoya Tanabe; Atsuyasu Sato; Emiko Ogawa; Shigeo Muro; Toyohiro Hirai; Michiaki Mishima

  BMC PULMONARY MEDICINE, May 2014, Peer-reviewed

  
• CTを用いた閉塞性肺疾患における気管支内腔の不整度に関する検討

  OGUMA TAKESHI; HIRAI TOYOHIRO; MATSUMOTO HISAKO; ITO ISAO; TAJIRI TOMOKO; NAGASAKI TADAO; KANEMITSU SADAHIRO; IDEHARA YUMI; MURO SHIGEO; MISHIMA MICHIAKI

  日本呼吸器学会誌, 10 Mar. 2014

  
• COPD悪化マウスモデルにおける好中球性炎症と肺気腫進行に対するチオレドキシン-1の効果(Effect of thioredoxin-1 on neutrophilic inflammation and emphysema progression in a mouse model of COPD exacerbation)

  田辺 直也; 星野 勇馬; 丸毛 聡; 清川 寛文; 黄瀬 大輔; 佐藤 晋; 宇野 賀津子; 室 繁郎; 平井 豊博; 淀井 淳司; 三嶋 理晃

  日本呼吸器学会誌, Mar. 2014

  
• Vitamin C Prevents Cigarette Smoke-Induced Pulmonary Emphysema in Mice and Provides Pulmonary Restoration

  Kengo Koike; Akihito Ishigami; Yasunori Sato; Toyohiro Hirai; Yiming Yuan; Etsuko Kobayashi; Kazunori Tobino; Tadashi Sato; Mitsuaki Sekiya; Kazuhisa Takahashi; Yoshinosuke Fukuchi; Naoki Maruyama; Kuniaki Seyama

  AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, Feb. 2014, Peer-reviewed

  
• Association between polyclonal and mixed mycobacterial mycobacterium avium complex infection and environmental exposure

  K. Fujita; Y. Ito; T. Hirai; T. Kubo; K. Maekawa; K. Togashi; S. Ichiyama; M. Mishima

  Annals of the American Thoracic Society, Jan. 2014, Peer-reviewed

  
• 呼吸不全に関する調査研究 若年発症重症COPDの全国疫学調査

  HIRAI TOYOHIRO; MURO SHIGEO; MISHIMA MICHIAKI

  呼吸不全に関する調査研究 平成25年度 総括・分担研究報告書(1/2冊), 2014

  
• Association between polyclonal and mixed mycobacterial Mycobacterium avium complex infection and environmental exposure

  Fujita,K; Ito,Y; Hirai,T; Kubo,T; Maekawa,K; Togashi,K; Ichiyama,S; Mishima,M

  Annals of the American Thoracic Society, 2014, Peer-reviewed

  
• 肺Mycobacterium avium complex症患者における病原微生物の重複感染とそのリスク要因

  藤田 浩平; 伊藤 穣; 平井 豊博; 前川 晃一; 久保 武; 富樫 かおり; 三嶋 理晃

  感染症学雑誌, 2014, Peer-reviewed

  
• 間質性肺疾患を合併した多発性筋炎/皮膚筋炎患者における血清プロスタグランジンF2α代謝産物濃度

  中塚 賀也; 半田 知宏; 祖開 暁彦; 池添 浩平; 平井 豊博; 三嶋 理晃; 谷澤 公伸; 小賀 徹; 陳 和夫; 細野 裕司; 中嶋 蘭; 三森 経世; 久保 武; 田口 善夫; 八田 和弘

  日本呼吸器学会誌, 2014

  
• Thioredoxin-1 Protects against Neutrophilic Inflammation and Emphysema Progression in a Mouse Model of Chronic Obstructive Pulmonary Disease Exacerbation

  Naoya Tanabe; Yuma Hoshino; Satoshi Marumo; Hirofumi Kiyokawa; Susumu Sato; Daisuke Kinose; Kazuko Uno; Shigeo Muro; Toyohiro Hirai; Junji Yodoi; Michiaki Mishima

  PLOS ONE, Nov. 2013, Peer-reviewed

  
• Limitations of Airway Dimension Measurement on Images Obtained Using Multi-Detector Row Computed Tomography

  Tsuyoshi Oguma; Toyohiro Hirai; Akio Niimi; Hisako Matsumoto; Shigeo Muro; Michio Shigematsu; Takashi Nishimura; Yoshiro Kubo; Michiaki Mishima

  PLOS ONE, Oct. 2013, Peer-reviewed

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• [Secondary osteoporosis or secondary contributors to bone loss in fracture. Abnormal bone metabolism in pulmonary diseases].

  Hirai T

  Clinical calcium, Sep. 2013, Peer-reviewed

  
• High-resolution computed tomography and health-related quality of life in Mycobacterium avium complex disease

  K. Maekawa; Yutaka Ito; T. Oga; T. Hirai; T. Kubo; K. Fujita; S. Imai; A. Niimi; K. Chin; S. Ichiyama; K. Togashi; M. Mishima

  International Journal of Tuberculosis and Lung Disease, 01 Jun. 2013, Peer-reviewed

  
• Genetic relatedness of Mycobacterium avium-intracellulare complex isolates from patients with pulmonary MAC disease and their residential soils

  K. Fujita; Y. Ito; T. Hirai; K. Maekawa; S. Imai; S. Tatsumi; A. Niimi; Y. Iinuma; S. Ichiyama; M. Mishima

  CLINICAL MICROBIOLOGY AND INFECTION, Jun. 2013, Peer-reviewed

  
• 成人肺炎球菌性市中肺炎の多施設共同前向き調査 2011年分報告

  伊藤 穣; 古田 健二郎; 加持 雄介; 郷間 巌; 伊藤 功朗; 冨岡 洋海; 橘 洋正; 今井 誠一郎; 藤田 浩平; 平井 豊博; 関西市中感染肺炎球菌性肺炎研究グループ

  感染症学雑誌, May 2013

  
• 特発性肺線維症患者におけるNeutrophil gelatinase‐associated lipocalin(NGAL)の検討

  IKEZOE KOHEI; HANDA TOMOHIRO; MORI KIYOSHI; WATANABE KIZUKU; AIHARA KENSAKU; TANIZAWA KIMINOBU; SOKAI AKIHIKO; KUBO TAKESHI; MURO SHIGEO; NAGAI SONOKO; HIRAI TOYOHIRO; CHIN KAZUO; MISHIMA MICHIAKI

  日本呼吸器学会誌, 10 Mar. 2013

  
• 当院で臓器移植ネットワークに登録した特発性間質性肺炎患者の臨床,画像的検討

  IKEZOE KOHEI; HANDA TOMOHIRO; KUBO TAKESHI; TANIZAWA KIMINOBU; AIHARA KENSAKU; SOKAI AKIHIKO; MURO SHIGEO; CHIN TOYOFUMI; AOYAMA AKIHIRO; SATO MASAAKI; BANDO TOORU; NAGAI SONOKO; HIRAI TOYOHIRO; CHIN KAZUO; DATE HIROSHI; MISHIMA MICHIAKI

  日本呼吸器学会誌, 10 Mar. 2013

  
• 成人肺炎球菌性市中肺炎の多施設共同前向き調査 2010年分報告

  伊藤 穣; 古田 健二郎; 加持 雄介; 伊藤 功朗; 冨岡 洋海; 郷間 巌; 橘 洋正; 今井 誠一郎; 藤田 浩平; 平井 豊博; 大成 功一; 平林 正孝; 三嶋 理晃

  感染症学雑誌, Mar. 2013

  
• [Pulmonary diseases and bone].

  Hirai T

  Clinical calcium, Feb. 2013, Peer-reviewed

  
• サルコイドーシス患者の気道過敏性評価におけるimpulse oscillometry(IOS)の有用性

  谷澤 公伸; 半田 知宏; 長井 苑子; 新実 彰男; 相原 顕作; 池添 浩平; 渡辺 創; 久保 武; 平井 豊博; 陳 和夫; 三嶋 理晃

  日本サルコイドーシス/肉芽腫性疾患学会雑誌, 2013, Peer-reviewed

  
• The Expression of Vascular Endothelial Growth Factor Receptor 2 in Peripheral Airway Epithelial Cells and Vessels in Early Chronic Obstructive Pulmonary Disease.

  Takahashi T; Ogawa E; Haruna A; Kiyokawa H; Sato S; Hoshino Y; Muro S; Hirai T; Sakai H; Nakano Y; Mishima M

  American Thoracic Society Annual Meeting, 2013

  
• 喘息/COPDの基礎研究最前線 喫煙による肺気腫進展の空間的不均一性について COPD患者の胸部CTを用いた縦断的検討

  Shigeo Muro

  International Review of Asthma & COPD, 2013

  
• 肺MAC症における気道病変の定量的評価に関する検討

  平井 豊博; 伊藤 穣; 小熊 毅; 藤田 浩平; 今井 誠一郎; 三嶋 理晃

  結核, Nov. 2012

  
• Peri-diaphragmatic lung volume assessed by computed tomography correlates with quality of life in patients with chronic obstructive pulmonary disease

  Naoya Tanabe; Shigeo Muro; Yoshinori Fuseya; Susumu Sato; Tsuyoshi Oguma; Hirofumi Kiyokawa; Tamaki Takahashi; Daisuke Kinose; Yuma Hoshino; Takeshi Kubo; Toyohiro Hirai; Michiaki Mishima

  RESPIROLOGY, Oct. 2012, Peer-reviewed

  
• Longitudinal Study of Spatially Heterogeneous Emphysema Progression in Current Smokers with Chronic Obstructive Pulmonary Disease

  Naoya Tanabe; Shigeo Muro; Susumu Sato; Shiro Tanaka; Tsuyoshi Oguma; Hirofumi Kiyokawa; Tamaki Takahashi; Daisuke Kinose; Yuma Hoshino; Takeshi Kubo; Toyohiro Hirai; Michiaki Mishima

  PLOS ONE, Sep. 2012, Peer-reviewed

  
• Computed tomography assessment of pharmacological lung volume reduction induced by bronchodilators in COPD

  Naoya Tanabe; Shigeo Muro; Tsuyoshi Oguma; Susumu Sato; Hirofumi Kiyokawa; Tamaki Takahashi; Megumi Kudo; Daisuke Kinose; Takeshi Kubo; Yuma Hoshino; Emiko Ogawa; Toyohiro Hirai; Michiaki Mishima

  COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, Aug. 2012, Peer-reviewed

  
• Impact of COPD Exacerbations on Osteoporosis Assessed by Chest CT Scan

  Hirofumi Kiyokawa; Shigeo Muro; Tsuyoshi Oguma; Susumu Sato; Naoya Tanabe; Tamaki Takahashi; Megumi Kudo; Daisuke Kinose; Hiroshi Kondoh; Takeshi Kubo; Yuma Hoshino; Emiko Ogawa; Toyohiro Hirai; Michiaki Mishima

  COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, Jun. 2012, Peer-reviewed

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• Differentiation between Birt-Hogg-Dube syndrome and lymphangioleiomyomatosis: Quantitative analysis of pulmonary cysts on computed tomography of the chest in 66 females

  Kazunori Tobino; Toyohiro Hirai; Takeshi Johkoh; Masatoshi Kurihara; Kiminori Fujimoto; Noriyuki Tomiyama; Michiaki Mishima; Kazuhisa Takahashi; Kuniaki Seyama

  EUROPEAN JOURNAL OF RADIOLOGY, Jun. 2012, Peer-reviewed

  
• Pulmonary hemorrhage induced by epileptic seizure

  Masanori Azuma; Isao Ito; Riki Matsumoto; Toyohiro Hirai; Michiaki Mishima

  HEART & LUNG, May 2012, Peer-reviewed

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• Emphysema distribution and annual changes in pulmonary function in male patients with chronic obstructive pulmonary disease

  Naoya Tanabe; Shigeo Muro; Shiro Tanaka; Susumu Sato; Tsuyoshi Oguma; Hirofumi Kiyokawa; Tamaki Takahashi; Daisuke Kinose; Yuma Hoshino; Takeshi Kubo; Emiko Ogawa; Toyohiro Hirai; Michiaki Mishima

  Respiratory Research, 18 Apr. 2012, Peer-reviewed

  
• Emphysema distribution and annual changes in pulmonary function in male patients with chronic obstructive pulmonary disease

  Naoya Tanabe; Shigeo Muro; Shiro Tanaka; Susumu Sato; Tsuyoshi Oguma; Hirofumi Kiyokawa; Tamaki Takahashi; Daisuke Kinose; Yuma Hoshino; Takeshi Kubo; Emiko Ogawa; Toyohiro Hirai; Michiaki Mishima

  RESPIRATORY RESEARCH, Apr. 2012, Peer-reviewed

  
• Oxidative stress induced Interleukin-32 mRNA expression in human bronchial epithelial cells

  Megumi Kudo; Emiko Ogawa; Daisuke Kinose; Akane Haruna; Tamaki Takahashi; Naoya Tanabe; Satoshi Marumo; Yuma Hoshino; Toyohiro Hirai; Hiroaki Sakai; Shigeo Muro; Hiroshi Date; Michiaki Mishima

  Respiratory Research, 14 Mar. 2012, Peer-reviewed

  
• 肺MAC症診断5年後の予後因子について

  ITO YUTAKA; HIRAI TOYOHIRO; MAEKAWA KOICHI; FUJITA KOHEI; IMAI SEIICHIRO; TATSUMI SHUJI; HANDA TOMOHIRO; MATSUMOTO HISAKO; MURO SHIGEO; NIIMI AKIO; MISHIMA MICHIAKI

  日本呼吸器学会誌, 10 Mar. 2012

  
• Predictors of 5-year mortality in pulmonary Mycobacterium avium-intracellulare complex disease

  Y. Ito; T. Hirai; K. Maekawa; K. Fujita; S. Imai; S. Tatsumi; T. Handa; H. Matsumoto; S. Muro; A. Niimi; M. Mishima

  INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, Mar. 2012, Peer-reviewed

  
• 肺MAC症患者と非肺MAC症患者の居住土壌からのMACの分離頻度について

  藤田 浩平; 伊藤 穣; 平井 豊博; 前川 晃一; 今井 誠一郎; 辰巳 秀爾; 新実 彰男; 一山 智; 三嶋 理晃

  日本呼吸器学会誌, Mar. 2012

  
• Oxidative stress induced Interleukin-32 mRNA expression in human bronchial epithelial cells

  Megumi Kudo; Emiko Ogawa; Daisuke Kinose; Akane Haruna; Tamaki Takahashi; Naoya Tanabe; Satoshi Marumo; Yuma Hoshino; Toyohiro Hirai; Hiroaki Sakai; Shigeo Muro; Hiroshi Date; Michiaki Mishima

  RESPIRATORY RESEARCH, Mar. 2012, Peer-reviewed

  
• Clinical features and risk factors of tuberculosis in living-donor liver transplant recipients

  S. Imai; Y. Ito; T. Hirai; H. Imai; I. Ito; K. Maekawa; K. Chin; S. Ichiyama; S. Uemoto; M. Mishima

  TRANSPLANT INFECTIOUS DISEASE, Feb. 2012, Peer-reviewed

  
• A NOD2 gene polymorphism is associated with the prevalence and severity of chronic obstructive pulmonary disease in a Japanese population

  Daisuke Kinose; Emiko Ogawa; Tomomitsu Hirota; Isao Ito; Megumi Kudo; Akane Haruna; Satoshi Marumo; Yuma Hoshino; Shigeo Muro; Toyohiro Hirai; Hiroaki Sakai; Hiroshi Date; Mayumi Tamari; Michiaki Mishima

  RESPIROLOGY, Jan. 2012, Peer-reviewed

  
• Correlation Of Vascular Endothelial Growth Factor Receptor2 With Pulmonary Function And Emphysematous Change In Early Chronic Obstructive Pulmonary Disease.

  Takahashi T; Ogawa E; Haruna A; Kubo M; Kiyokawa H; Tanabe N; Kinose D; Sato S; Hoshino Y; Hirai T; Sakai H; Nakano Y; Muro S; Mishima M

  American Thoracic Society Annual Meeting, 2012

  
• Environmental Risk Factors for Pulmonary Mycobacterium avium-intracellulare Complex Disease

  Koichi Maekawa; Yutaka Ito; Toyohiro Hirai; Takeshi Kubo; Seiichiro Imai; Shuji Tatsumi; Kohei Fujita; Shunji Takakura; Akio Niimi; Yoshitsugu Iinuma; Satoshi Ichiyama; Kaori Togashi; Michiaki Mishima

  CHEST, Sep. 2011, Peer-reviewed

  
• Keratinocyte Growth Factor Gene Transduction Ameliorates Pulmonary Fibrosis Induced by Bleomycin in Mice

  Seiko Sakamoto; Takuya Yazawa; Yasuko Baba; Hanako Sato; Yumi Kanegae; Toyohiro Hirai; Izumu Saito; Takahisa Goto; Kiyoyasu Kurahashi

  AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, Sep. 2011, Peer-reviewed

  
• Distribution and clonal relationship of cell surface virulence genes among Streptococcus pneumoniae isolates in Japan

  S. Imai; Y. Ito; T. Ishida; T. Hirai; I. Ito; K. Yoshimura; K. Maekawa; S. Takakura; A. Niimi; Y. Iinuma; S. Ichiyama; M. Mishima

  CLINICAL MICROBIOLOGY AND INFECTION, Sep. 2011, Peer-reviewed

  
• Impact of Exacerbations on Emphysema Progression in Chronic Obstructive Pulmonary Disease

  Naoya Tanabe; Shigeo Muro; Toyohiro Hirai; Tsuyoshi Oguma; Kunihiko Terada; Satoshi Marumo; Daisuke Kinose; Emiko Ogawa; Yuma Hoshino; Michiaki Mishima

  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Jun. 2011, Peer-reviewed

  
• COPDの予後についての検討

  HARUNA AKANE; MURO SHIGEO; NISHIMURA NAOSHI; HOSHINO YUUMA; OGAWA EMIKO; HIRAI TOYOHIRO; NAKANO YASUTAKA; NISHIMURA KOICHI; MISHIMA MICHIAKI

  日本呼吸器学会雑誌, 10 Mar. 2011

  
• 成人市中肺炎患者由来の肺炎球菌血清型の検討 2003-2004年調査と2008-2009年調査の比較

  伊藤 穣; 今井 誠一郎; 前川 晃一; 辰巳 秀爾; 藤田 浩平; 伊藤 功朗; 平井 豊博; 高倉 俊二; 一山 智

  感染症学雑誌, Mar. 2011

  
• 肺MAC症における環境危険因子の検討

  前川 晃一; 伊藤 穣; 平井 豊博; 今井 誠一郎; 辰巳 秀爾; 高倉 俊二; 新実 彰男; 飯沼 由嗣; 一山 智; 三嶋 理晃

  結核, Mar. 2011

  
• COPD COPD患者における血中SP-Dの検討

  田辺 直也; 室 繁郎; 高橋 珠紀; 清川 寛文; 工藤 恵; 丸毛 聡; 黄瀬 大輔; 星野 勇馬; 平井 豊博; 三嶋 理晃

  日本呼吸器学会雑誌, Mar. 2011

  
• Underweight and pulmonary diseases

  T. Hirai

  Respiration and Circulation, 2011, Peer-reviewed

  
• [Criteria for designation of lymphangioleiomyomatosis in the Specified Disease Treatment Research Program].

  M. Hayashida; K. Seyama; Y. Inoue; T. Hirai; M. Mishima; Respiratory Failure; Research Group; Japanese Ministry of Health; Labor; and Welfare

  Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society, 2011, Peer-reviewed

  
• Association of Alveolar Nitric Oxide Levels with Pulmonary Function and Its Reversibility in Stable Asthma

  Hisako Matsumoto; Akio Niimi; Makiko Jinnai; Hitoshi Nakaji; Tomoshi Takeda; Tsuyoshi Oguma; Kojiro Otsuka; Hideki Inoue; Masafumi Yamaguchi; Hirofumi Matsuoka; Isao Ito; Toyohiro Hirai; Kazuo Chin; Michiaki Mishima

  RESPIRATION, 2011, Peer-reviewed

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• 呼吸不全に関する調査研究 胸部CTでの気腫化病変とCOPD患者の予後との関連

  MURO SHIGEO; HARUNA AKANE; KUDO MEGUMI; TANABE NAOYA; KIYOKAWA HIROFUMI; KISE DAISUKE; HOSHINO YUUMA; HIRAI TOYOHIRO; MISHIMA MICHIAKI

  呼吸不全に関する調査研究 平成22年度 研究報告書, 2011

  
• 呼吸不全に関する調査研究 血清歯周病抗体価と慢性閉塞性肺疾患(COPD)増悪との関連性

  MURO SHIGEO; TAKAHASHI TAMAKI; KUDO MEGUMI; TANABE NAOYA; KIYOKAWA HIROFUMI; KISE DAISUKE; HOSHINO YUUMA; HIRAI TOYOHIRO; MISHIMA MICHIAKI

  呼吸不全に関する調査研究 平成22年度 研究報告書, 2011

  
• Oxidative stress augmented IL-32 gene upregulation in airway epithelial cells.

  Kudo M; Ogawa E; Haruna A; Kinose D; Hoshino Y; Muro S; Hirai T; Mishima M

  American Thoracic Society Annual Meeting, 2011

  
• Distinct responses against polyinosine-polycytidylic acid in smoke-exposed mouse strains with different susceptibility to emphysema

  Tanabe N; Hoshino Y; Kiyokawa H; Marumo S; Ogawa E; Muro S; Hirai T; Mishima M

  American Thoracic Society Annual Meeting, 2011

  
• The effect of telling smokers their "lung age" on smoking quit rate at annual health checkup

  Marumo S; Muro S; Haruna A; Sato A; Ogawa E; Hoshino Y; Hirai T; Mishima M; A. Sato

  American Thoracic Society Annual Meeting, 2011

  
• NOD2 SNPs associated with Crohn's disease were not found in Japanese COPD patients, [Publication Page: A2886]

  Kinose D; Ogawa E; Nishioka M; Hoshino Y; Hirai T; Muro S; Mishima M

  American Thoracic Society Annual Meeting, 2011

  
• 呼吸不全に関する調査研究 酸化ストレスがヒト気道上皮細胞におけるIL‐32発現に与える影響

  KUDO MEGUMI; OGAWA EMIKO; KISE DAISUKE; HARUNA AKANE; TAKAHASHI TAMAKI; KIYOKAWA HIROFUMI; TANABE NAOYA; MARUMO SATOSHI; HOSHINO YUUMA; MURO SHIGEO; HIRAI TOYOHIRO; MISHIMA MICHIAKI

  呼吸不全に関する調査研究 平成22年度 研究報告書, 2011

  
• 呼吸不全に関する調査研究 喫煙暴露にウイルス疑似刺激を加えるモデルによるCOPD増悪の病態解明(続報)

  TANABE NAOYA; HOSHINO YUUMA; KIYOKAWA HIROFUMI; MARUMO SATOSHI; OGAWA EMIKO; MURO SHIGEO; HIRAI TOYOHIRO; MISHIMA MICHIAKI

  呼吸不全に関する調査研究 平成22年度 研究報告書, 2011

  
• Long-term changes in airway-wall thickness on computed tomography in asthmatic patients

  H. Matsumoto; A. Niimi; M. Takemura; T. Ueda; M. Yamaguchi; H. Matsuoka; M. Jinnai; T. Takeda; K. Otsuka; T. Oguma; T. Handa; T. Hirai; K. Chin; M. Mishima

  Journal of Investigational Allergology and Clinical Immunology, 2011, Peer-reviewed

  
• 市中肺炎患者から分離された肺炎球菌について細胞表面発現分子の検討

  今井 誠一郎; 伊藤 穣; 石田 直; 平井 豊博; 伊藤 功朗; 前川 晃一; 高倉 俊二; 飯沼 由嗣; 一山 智

  感染症学雑誌, Nov. 2010

  
• CT Scan Findings of Emphysema Predict Mortality in COPD

  Akane Haruna; Shigeo Muro; Yasutaka Nakano; Tadashi Ohara; Yuma Hoshino; Emiko Ogawa; Toyohiro Hirai; Akio Niimi; Koichi Nishimura; Kazuo Chin; Michiaki Mishima

  CHEST, Sep. 2010, Peer-reviewed

  
• Lipopolysaccharide induced connective tissue growth factor gene expression in human bronchial epithelial cells

  Michiyoshi Nishioka; Emiko Ogawa; Daisuke Kinose; Akane Haruna; Tadashi Ohara; Isao Ito; Yuma Hoshino; Yutaka Ito; Hisako Matsumoto; Akio Niimi; Tadashi Mio; Kazuo Chin; Toyohiro Hirai; Shigeo Muro; Michiaki Mishima

  RESPIROLOGY, May 2010, Peer-reviewed

  
• 肺MAC症の胸部CT評価におけるCTスコアリング法の信頼性、有用性の検討

  前川 晃一; 伊藤 穣; 今井 誠一郎; 平井 豊博; 三嶋 理晃

  結核, Apr. 2010

  
• 結核患者におけるToll like receptor(TLR)ligand刺激後のTNFα産生能の比較

  今井 誠一郎; 伊藤 穣; 平井 豊博; 前川 晃一; 飯沼 由嗣; 一山 智; 三嶋 理晃

  結核, Apr. 2010

  
• 健診における肺年齢伝達による禁煙促進効果

  MARUMO SATOSHI; MURO SHIGEO; HARUNA AKANE; SATO ATSUYASU; OGAWA EMIKO; HOSHINO YUUMA; HIRAI TOYOHIRO; MISHIMA MICHIAKI; SATO ATSUHIKO

  日本呼吸器学会雑誌, 20 Mar. 2010

  
• 市中肺炎患者から分離された肺炎球菌について細胞表面発現分子の検討

  今井 誠一郎; 伊藤 穣; 石田 直; 平井 豊博; 伊藤 功朗; 前川 晃一; 高倉 俊二; 飯沼 由嗣; 一山 智

  感染症学雑誌, Mar. 2010

  
• 感染症・結核 生体肝移植後に発症した結核症例の発症危険因子の検討

  今井 誠一郎; 伊藤 穣; 伊藤 功朗; 平井 豊博; 前川 晃一; 今井 寿; 陳 和夫; 上本 伸二; 三嶋 理晃

  日本呼吸器学会雑誌, Mar. 2010

  
• 肺MAC症患者のQOL評価におけるSGRQの妥当性の検討

  前川 晃一; 伊藤 穣; 今井 誠一郎; 平井 豊博; 三嶋 理晃; 小賀 徹; 陳 和夫

  日本呼吸器学会雑誌, Mar. 2010

  
• 胸部CT画像の定量解析を用いた嚢胞性肺疾患と肺気腫の病態の比較検討

  飛野 和則; 瀬山 邦明; 平井 豊博; 栗原 正利; 上甲 剛; 三嶋 理晃; 高橋 和久

  日本呼吸器学会雑誌, Mar. 2010

  
• Abnormal Swallowing Reflex and COPD Exacerbations

  Kunihiko Terada; Shigeo Muro; Tadashi Ohara; Megumi Kudo; Emiko Ogawa; Yuma Hoshino; Toyohiro Hirai; Akio Niimi; Kazuo Chin; Michiaki Mishima

  CHEST, Feb. 2010, Peer-reviewed

  
• [Pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension].

  K. Tatsumi; N. Nakanishi; N. Tanabe; Y. Kasahara; K. Kubo; T. Hirai; M. Mishima

  Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society, 2010, Peer-reviewed

  
• Diagnostic criteria and case card for LAM

  T. Hirai

  Respiration and Circulation, 2010, Peer-reviewed

  
• the Kansai Community Acquired Pneumococcal Pneumonia Study Group. Clin Microbiol Infect. 2010

  Imai S; Ito Y; Ishida T; Hirai T; Ito I; Yoshimura K; Maekawa K; Takakura S; Niimi A; Iinuma Y; Ichiyama S; Mishima M

  2010, Peer-reviewed

  
• Age-Related Changes in the Trachea in Healthy Adults

  Hiroaki Sakai; Yasutaka Nakano; Shigeo Muro; Toyohiro Hirai; Yasutaka Takubo; Yoshitaka Oku; Hiroshi Hamakawa; Ayuko Takahashi; Toshihiko Sato; Fengshi Chen; Hisashi Sahara; Takuji Fujinaga; Kiyoshi Sato; Makoto Sonobe; Tsuyoshi Shoji; Ryo Miyahara; Kenichi Okubo; Toru Bando; Toshiki Hirata; Hiroshi Date; Michiaki Mishima

  OXYGEN TRANSPORT TO TISSUE XXXI, 2010, Peer-reviewed

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• Relationship between peripheral airway function and patient-reported outcomes in COPD: a cross-sectional study

  Akane Haruna; Toru Oga; Shigeo Muro; Tadashi Ohara; Susumu Sato; Satoshi Marumo; Daisuke Kinose; Kunihiko Terada; Michiyoshi Nishioka; Emiko Ogawa; Yuma Hoshino; Toyohiro Hirai; Kazuo Chin; Michiaki Mishima

  BMC PULMONARY MEDICINE, 2010, Peer-reviewed

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• 呼吸不全に関する調査研究 喫煙暴露にウイルス疑似刺激を加えるモデルによるCOPD増悪の病態解明

  TANABE NAOYA; HOSHINO YUUMA; KIYOKAWA HIROFUMI; MARUMO SATOSHI; OGAWA EMIKO; MURO SHIGEO; HIRAI TOYOHIRO; MISHIMA MICHIAKI

  呼吸不全に関する調査研究班 平成21年度 研究報告書, 2010

  
• 呼吸不全に関する調査研究 喫煙曝露による肺気腫モデルマウスにおける禁煙後の病態生理に関する研究

  MARUMO SATOSHI; HOSHINO YUUMA; TANABE NAOYA; SATO ATSUYASU; OGAWA EMIKO; MURO SHIGEO; HIRAI TOYOHIRO; MISHIMA MICHIAKI

  呼吸不全に関する調査研究班 平成21年度 研究報告書, 2010

  
• Abnormal swallowing reflex and COPD exacerbations

  K. Terada; S. Muro; T. Ohara; M. Kudo; E. Ogawa; Y. Hoshino; T. Hirai; A. Niimi; K. Chin; M. Mishima

  Dysphagia, 2010, Peer-reviewed

  
• High prevalence of multidrug-resistant Pneumococcal molecular epidemiology network clones among Streptococcus pneumoniae isolates from adult patients with community-acquired pneumonia in Japan

  S. Imai; Y. Ito; T. Ishida; T. Hirai; I. Ito; K. Maekawa; S. Takakura; Y. Iinuma; S. Ichiyama; M. Mishima

  CLINICAL MICROBIOLOGY AND INFECTION, Nov. 2009, Peer-reviewed

  
• Cough-reflex sensitivity to inhaled capsaicin in COPD associated with increased exacerbation frequency

  Kunihiko Terada; Shigeo Muro; Tadashi Ohara; Akane Haruna; Satoshi Marumo; Megumi Kudo; Emiko Ogawa; Yuma Hoshino; Toyohiro Hirai; Akio Niimi; Michiaki Mishima

  RESPIROLOGY, Nov. 2009, Peer-reviewed

  
• Effect of inhaled corticosteroids on small airways in asthma: Investigation using impulse oscillometry

  Masafumi Yamaguchi; Akio Niimi; Tetsuya Ueda; Masaya Takemura; Hirofumi Matsuoka; Makiko Jinnai; Kojiro Otsuka; Tsuyoshi Oguma; Tomoshi Takeda; Isao Ito; Hisako Matsumoto; Toyohiro Hirai; Kazuo Chin; Michiaki Mishima

  PULMONARY PHARMACOLOGY & THERAPEUTICS, Aug. 2009, Peer-reviewed

  
• 気胸・嚢胞性肺疾患の診断および治療への遺伝子解析的アプローチ Birt-Hogg-Dube症候群における嚢胞性変化と呼吸機能の検討

  飛野 和則; 瀬山 邦明; 栗原 正利; 平井 豊博; 久能木 真喜子; 星加 義人; 高橋 和久

  日本気胸・嚢胞性肺疾患学会雑誌, Aug. 2009

  
• MMP‐9プロモータ遺伝子多型は上肺野優位の肺気腫病変と関連する

  ITO YOSHIRO; NAGAI SONOKO; HANDA TOMOHIRO; MURO SHIGEO; HIRAI TOYOHIRO; TSUKINO MITSUHIRO; MISHIMA MICHIAKI

  日本呼吸器学会雑誌, 10 May 2009

  
• 肺MAC症の胸部CT評価におけるCTスコアリング法の有用性の検討

  前川 晃一; 伊藤 穣; 今井 誠一郎; 平井 豊博; 三嶋 理晃

  日本呼吸器学会雑誌, May 2009

  
• 胸部CT画像の定量的解析を用いたBirt-Hogg-Dube症候群とリンパ脈管筋腫症の比較

  飛野 和則; 瀬山 邦明; 栗原 正利; 平井 豊博; 郡司 陽子; 森 貴紀; 富山 憲幸; 上甲 剛; 高橋 和久

  日本呼吸器学会雑誌, May 2009

  
• 肺炎球菌 肺炎球菌クローン株におけるマクロライド耐性遺伝子含有トランスポゾンの解析

  伊藤 穣; 飯沼 由嗣; 今井 誠一郎; 石田 直; 平井 豊博; 伊藤 功朗; 前川 晃一; 高倉 俊二; 一山 智; 三嶋 理晃

  日本細菌学雑誌, Feb. 2009

  
• Morphological model simulations in the development of pulmonary emphysema

  T. Hirai

  Respiration and Circulation, 2009, Peer-reviewed

  
• Body mass index in male patients with COPD: correlation with low attenuation areas on CT

  E. Ogawa; Y. Nakano; T. Ohara; S. Muro; T. Hirai; S. Sato; H. Sakai; M. Tsukino; D. Kinose; M. Nishioka; A. Niimi; K. Chin; P. D. Pare; M. Mishima

  THORAX, Jan. 2009, Peer-reviewed

  
• Computed Tomography Analysis of Airway Dimensions and Lung Density in Patients with Sarcoidosis

  Tomohiro Handa; Sonoko Nagai; Toyohiro Hirai; Kazuo Chin; Takeshi Kubo; Toru Oga; Akio Niimi; Hisako Matsumoto; Yutaka Ito; Kenichi Takahashi; Kizuku Watanabe; Takateru Izumi; Michiaki Mishima

  RESPIRATION, 2009, Peer-reviewed

  
• 呼吸不全に関する調査研究班 COPD患者におけるImpulse oscillometry(IOS)による呼吸抵抗と患者報告型アウトカムとの関連

  HARUNA AKANE; OGA TOORU; MURO SHIGEO; TERADA KUNIHIKO; KUDO MEGUMI; KISE DAISUKE; MARUMO SATOSHI; HOSHINO YUUMA; OGAWA EMIKO; HIRAI TOYOHIRO; CHIN KAZUO; MISHIMA MICHIAKI

  呼吸不全に関する調査研究班 平成20年度 研究報告書, 2009

  
• 呼吸不全に関する調査研究班 嚥下反射の低下がCOPD患者のQOLに与える影響の横断的研究,および増悪に与える影響についての前向き研究

  TERADA KUNIHIKO; MURO SHIGEO; KUDO MEGUMI; HARUNA AKANE; KISE DAISUKE; MARUMO SATOSHI; HIRAI TOYOHIRO; HOSHINO YUUMA; OGAWA EMIKO; MISHIMA MICHIAKI

  呼吸不全に関する調査研究班 平成20年度 研究報告書, 2009

  
• 呼吸不全に関する調査研究班 p38MAPKを介した喫煙による肺炎症・障害の病態解析

  MARUMO SATOSHI; HOSHINO YUUMA; MURO SHIGEO; TANABE NAOYA; HARUNA AKANE; TERADA KUNIHIKO; KUDO MEGUMI; KISE DAISUKE; OGAWA EMIKO; HIRAI TOYOHIRO; MISHIMA MICHIAKI

  呼吸不全に関する調査研究班 平成20年度 研究報告書, 2009

  
• 呼吸不全に関する調査研究班 胸壁の脂肪量と胸部CTにおける低吸収領域との関連

  OGAWA EMIKO; NAKANO YASUTAKA; MURO SHIGEO; OHARA NAO; SAKAI HIROAKI; TSUKINO MITSUHIRO; HIRAI TOYOHIRO; MISHIMA MICHIAKI

  呼吸不全に関する調査研究班 平成20年度 研究報告書, 2009

  
• Relationship Between Pulmonary Emphysema and Osteoporosis Assessed by CT in Patients With COPD

  Tadashi Ohara; Toyohiro Hirai; Shigeo Muro; Akane Haruna; Kunihiko Terada; Daisuke Kinose; Satoshi Marumo; Emiko Ogawa; Yuma Hoshino; Akio Niimi; Kazuo Chin; Michiaki Mishima

  CHEST, Dec. 2008, Peer-reviewed

  
• サルコイドーシス症例における気道と肺野のCT画像解析

  HANDA TOMOHIRO; NAGAI SONOKO; HIRAI TOYOHIRO; CHIN KAZUO; KUBO TAKESHI; OGA TOORU; NIIMI AKIO; MATSUMOTO HISAKO; ITO YUTAKA; TAKAHASHI KEN'ICHI; WATANABE KIZUKU; IZUMI TAKATERU; MISHIMA MICHIAKI

  サルコイドーシス/肉芽腫性疾患, 01 Oct. 2008

  
• 胸部CT画像の定量的解析を用いたBirt-Hogg-Dube症候群とリンパ脈管筋腫症の比較とその鑑別診断

  飛野 和則; 瀬山 邦明; 栗原 正利; 平井 豊博; 秋吉 妙子; 郡司 陽子; 児玉 裕三; 高橋 和久

  日本気胸・嚢胞性肺疾患学会雑誌, Aug. 2008

  
• Longitudinal study of airway dimensions in chronic obstructive pulmonary disease using computed tomography

  Tadashi Ohara; Toyohiro Hirai; Susumu Sato; Kunihiko Terada; Daisuke Kinose; Akane Haruna; Satoshi Marumo; Michiyoshi Nishioka; Emiko Ogawa; Yasutaka Nakano; Yuma Hoshino; Yutaka Ito; Hisako Matsumoto; Akio Niimi; Tadashi Mio; Kazuo Chin; Shigeo Muro; Michiaki Mishima

  RESPIROLOGY, May 2008, Peer-reviewed

  
• Longitudinal study of airway dimensions in chronic obstructive pulmonary disease using computed tomography

  Tadashi Ohara; Toyohiro Hirai; Susumu Sato; Kunihiko Terada; Daisuke Kinose; Akane Haruna; Satoshi Marumo; Michiyoshi Nishioka; Emiko Ogawa; Yasutaka Nakano; Yuma Hoshino; Yutaka Ito; Hisako Matsumoto; Akio Niimi; Tadashi Mio; Kazuo Chin; Shigeo Muro; Michiaki Mishima

  RESPIROLOGY, May 2008, Peer-reviewed

  
• 肺MAC症患者の画像所見悪化を予測する因子についての解析

  前川 晃一; 伊藤 穣; 今井 誠一郎; 平井 豊博; 三嶋 理晃

  日本呼吸器学会雑誌, May 2008

  
• Birt-Hogg-Dube症候群の胸部HRCTの特徴の検討

  飛野 和則; 瀬山 邦明; 川村 亮英; 栗原 正利; 平井 豊博; 高橋 和久

  日本呼吸器学会雑誌, May 2008

  
• LipopolysaccharideによるConnective Tissue Growth Factor遺伝子発現と調節機序

  NISHIOKA NOBUYOSHI; OGAWA EMIKO; HARUNA AKANE; KISE DAISUKE; HOSHINO YUUMA; HIRAI TOYOHIRO; MURO SHIGEO; MISHIMA MICHIAKI

  日本呼吸器学会雑誌, May 2008

  
• Antimicrobial susceptibilities of Streptococcus pneumoniae isolated from adult patients with community-acquired pneumonia in Japan

  Tadashi Ishida; Ko Maniwa; Hitoshi Kagioka; Masataka Hirabayashi; Koichi Onaru; Hiromi Tomioka; Michio Hayashi; Keisuke Tomii; Iwao Gohma; Yutaka Ito; Toyohiro Hirai; Isao Ito; Michiaki Mishima

  RESPIROLOGY, Mar. 2008, Peer-reviewed

  
• Animal models of COPD

  T. Hirai

  Respiration and Circulation, 2008, Peer-reviewed

  
• Birt-hogg-dubé syndrome: Topics of the new hereditary cystic lung disease

  K. Tobino; Y. Gunji; T. Akiyoshi; K. Koike; M. Kurihara; T. Hirai; K. Seyama

  Japanese Journal of Chest Diseases, 2008, Peer-reviewed

  
• Distribution and clonal relationship of cell surface virulence genes among Streptococcus pneumoniae isolates in Japan.

  Imai S; Ito Y; Ishida T; Hirai T; Ito I; Yoshimura K; Maekawa K; Takakura S; Niimi A; Iinuma Y; Ichiyama S; Mishima M; the Kansai Community Acquired Pneumococcal Pneumonia Study Group. Clin Microbiol Infect; Handa T; Nagai S; Hirai T; Chin K; Kubo T; Oga T; Niimi A; Matsumoto H; Ito Y; Takahashi K; Watanabe K; Izumi T; Mishima M; Compute; tomography analysis of airway dimensions; lung density in; patients with; sarcoidosis. Respiratio; Ohara T; Hirai T; Muro S; Haruna A; Terada K; Kinose D; Marumo S; Ogawa E; Hoshino Y; Niimi A; Chin K; Mishima M. Relationship; between pulmonary emphysema; osteoporosis assessed; by CT in; patients with; COPD. Ches

  2008, Peer-reviewed

  
• Molecular characteristics of serotype 3 Streptococcus pneumoniae isolates among community-acquired pneumonia patients in Japan

  Rie Isozumi; Yutaka Ito; Tadashi Ishida; Toyohiro Hirai; Isao Ito; Ko Maniwa; Michio Hayashi; Hitoshi Kagioka; Masataka Hirabayashi; Koichi Onaru; Hiromi Tomioka; Keisuke Tomii; Iwao Gohma; Makoto Osawa; Seiichiro Imai; Shunji Takakura; Yoshitsugu Iinuma; Kazuo Chin; Satoshi Ichiyama; Michiaki Mishima

  Journal of Infection and Chemotherapy, 2008, Peer-reviewed

  
• 呼吸不全に関する調査研究 COPDにおける気腫病変と椎体骨密度との関係―胸部CT画像による検討―

  OHARA TADASHI; HIRAI TOYOHIRO; MURO SHIGEO; TERADA KUNIHIKO; KISE DAISUKE; HARUNA AKANE; MARUMO SATOSHI; KUDO MEGUMI; NISHIOKA TSUMORU; HOSHINO YUUMA; OGAWA EMIKO; CHIN KAZUO; MISHIMA MASAAKI

  呼吸不全に関する調査研究 平成19年度 研究報告書, 2008

  
• Pneumococcal surface protein A family types of Streptococcus pneumoniae from community-acquired pneumonia patients in Japan

  Y. Ito; M. Osawa; R. Isozumi; S. Imai; I. Ito; T. Hirai; T. Ishida; S. Ichiyama; M. Mishima

  EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, Oct. 2007, Peer-reviewed

  
• 嚢胞性肺疾患の診断と治療 リンパ脈管筋腫症(LAM)における胸部HRCT像と肺機能検査値の比較検討

  飛野 和則; 平井 豊博; 瀬山 邦明; 郡司 陽子; 栗原 正利; 佐藤 輝彦; 三嶋 理晃; 高橋 和久

  日本気胸・嚢胞性肺疾患学会雑誌, Aug. 2007

  
• Birt-Hogg-Dube(BHD)症候群の胸部HRCTおける肺嚢胞の特徴の検討

  飛野 和則; 平井 豊博; 瀬山 邦明; 栗原 正利; 秋吉 妙子; 児玉 裕三; 三嶋 理晃; 高橋 和久

  日本気胸・嚢胞性肺疾患学会雑誌, Aug. 2007

  
• Genotypes and related factors reflecting macrolide resistance in pneumococcal pneumonia infections in Japan

  Rie Isozumi; Yutaka Ito; Tadashi Ishida; Makoto Osawa; Toyohiro Hirai; Isao Ito; Ko Maniwa; Michio Hayashi; Hitoshi Kagioka; Masataka Hirabayashi; Koichi Onari; Hiromi Tomioka; Keisuke Tomii; Iwao Gohma; Seiichiro Imai; Shunji Takakura; Yoshitsugu Iinuma; Satoshi Ichiyama; Michiaki Mishima

  JOURNAL OF CLINICAL MICROBIOLOGY, May 2007, Peer-reviewed

  
• Risk factors for invasive aspergillosis in living donor liver transplant recipients

  Makoto Osawa; Yutaka Ito; Toyohiro Hirai; Rie Isozurni; Shunji Takakura; Yasuhiro Fujimoto; Yoshitsugu Iinuma; Satoshi Ichiyama; Koichi Tanaka; Michiaki Mishima

  LIVER TRANSPLANTATION, Apr. 2007, Peer-reviewed

  
• 生体肝移植後に発症した結核症例の臨床的検討

  今井 誠一郎; 伊藤 穣; 平井 豊博; 大澤 真; 五十棲 理恵; 前川 晃一; 陳 和夫; 三嶋 理晃

  結核, Apr. 2007

  
• 成人市中肺炎における血清型3型エリスロマイシン耐性肺炎球菌クローン株の検討

  五十棲 理恵; 伊藤 穣; 大沢 真; 平井 豊博; 今井 誠一郎; 前川 晃一; 高倉 俊二; 飯沼 由嗣; 一山 智; 三嶋 理晃

  日本呼吸器学会雑誌, Apr. 2007

  
• リンパ脈管筋腫症(LAM)における胸部HRCT像と肺機能検査値の比較検討

  飛野 和則; 瀬山 邦明; 平井 豊博; 郡司 陽子; 佐藤 輝彦; 三嶋 理晃; 高橋 和久

  日本呼吸器学会雑誌, Apr. 2007

  
• Morphological mechanism of the development of pulmonary emphysema in klotho mice

  Atsuyasu Sato; Toyohiro Hirai; Akihiro Imura; Naoko Kita; Akiko Iwano; Shigeo Muro; Yo-ichi Nabeshima; Bela Suki; Michiaki Mishima

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Feb. 2007, Peer-reviewed

  
• 呼吸不全に関する調査研究 klotho遺伝子欠損肺気腫モデルマウスの肺機能に関する検討

  SATO ATSUYASU; HIRAI TOYOHIRO; MURO SHIGEO; CHIN KAZUO; MISHIMA MASAAKI; IMURA AKIHIRO; NABESHIMA YOICHI

  呼吸不全に関する調査研究 平成18年度 研究報告書, 2007

  
• Role of small airways in asthma: Investigation using high-resolution computed tomography

  Tetsuya Ueda; Akio Niimi; Hisako Matsumoto; Masaya Takemura; Toyohiro Hirai; Masafumi Yamaguchi; Hirofumi Matsuoka; Makiko Jinnai; Shigeo Muro; Kazuo Chin; Michiaki Mishima

  JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Nov. 2006, Peer-reviewed

  
• 市中肺炎患者から分離された肺炎球菌由来のPneumococcal surface protein A(PspA)のtypingについての検討

  伊藤 穣; 大澤 真; 五十棲 理恵; 今井 誠一郎; 石田 直; 高倉 俊二; 飯沼 由嗣; 一山 智; 平井 豊博; 三嶋 理晃

  感染症学雑誌, Nov. 2006

  
• Comparison of airway dimensions in different anatomic locations on chest CT in patients with COPD

  Tadashi Ohara; Toyohiro Hirai; Susumu Sato; Atsuyasu Sato; Michiyoshi Nishioka; Shigeo Muro; Michiaki Mishima

  RESPIROLOGY, Sep. 2006, Peer-reviewed

  
• High sensitivity C-reactive protein in asthma

  M Takemura; H Matsumoto; A Niimi; T Ueda; H Matsuoka; M Yamaguchi; M Jinnai; S Muro; T Hirai; Y Ito; T Nakamura; T Mio; K Chin; M Mishima

  EUROPEAN RESPIRATORY JOURNAL, May 2006, Peer-reviewed

  
• 市中肺炎患者から分離された肺炎球菌由来のPneumococcal surface protein A(PspA)のtypingについての検討

  伊藤 穣; 大澤 真; 五十棲 理恵; 今井 誠一郎; 石田 直; 高倉 俊二; 飯沼 由嗣; 一山 智; 平井 豊博; 三嶋 理晃

  感染症学雑誌, Mar. 2006

  
• Prognosis of cough variant asthma: A retrospective analysis

  H Matsumoto; A Niimi; M Takemura; T Ueda; R Tabuena; M Yamaguchi; H Matsuoka; T Hirai; S Muro; Y Ito; T Mio; K Chin; H Nishiyama; M Mishima

  JOURNAL OF ASTHMA, 2006, Peer-reviewed

  
• Pulmonary infection of Mycobacterium avium-intracellulare complex with simultaneous organizing pneumonia

  Kunio Hamada; Sonoko Nagai; Yoshikazu Hara; Toyohiro Hirai; Michiaki Mishima

  INTERNAL MEDICINE, 2006, Peer-reviewed

  
• COPDの病態解析と治療法開発・治療評価への挑戦 CT画像解析・チオレドキシン創薬・アウトカムスタディを通して

  Shigeo Muro

  最新医学, 2006

  
• Matrix metalloproteinase-9 promoter polymorphism associated with upper lung dominant emphysema

  Ito, I; S Nagai; T Handa; S Muro; T Hirai; M Tsukino; M Mishima

  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Dec. 2005, Peer-reviewed

  
• An outbreak of Legionella pneumonia originating from a cooling tower

  R Isozumi; Y Ito; Ito, I; M Osawa; T Hirai; S Takakura; Y Iinuma; S Ichiyama; K Tateda; K Yamaguchi; M Mishima

  SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, Oct. 2005, Peer-reviewed

  
• Relationship of airway wall thickening to an imbalance between matrix metalloproteinase-9 and its inhibitor in asthma

  H Matsumoto; A Niimi; M Takemura; T Ueda; M Minakuchi; R Tabuena; K Chin; T Mio; Y Ito; S Muro; T Hirai; S Morita; S Fukuhara; M Mishima

  THORAX, Apr. 2005, Peer-reviewed

  
• Risk and severity of COPD is associated with the group-specific component of serum globulin 1F allele

  Ito, I; S Nagai; Y Hoshino; S Muro; T Hirai; M Tsukino; M Mishima

  CHEST, Jan. 2004, Peer-reviewed

  
• 炎症細胞,気道構成細胞と気道疾患 CT画像による喘息とCOPDの気道壁の比較

  新実 彰男; 中野 恭幸; 松本 久子; 室 繁郎; 平井 豊博; 三嶋 理晃

  日本呼吸器学会雑誌, Mar. 2003

  
• Evaluation of Airway Resistance using Impulse Oscillation System (IOS)

  T. Hirai; S. Sato; M. Mishima

  Respiration and Circulation, 2003, Peer-reviewed

  
• Study of COPD not showing emphysema image ( Ministry of Health and Welfare ).

  MISHIMA MASAAKI; MURO SHIGERO; NAKAMURA TAKAYA; HIRAI TOYOHIRO; CHIN KAZUO

  呼吸不全研究班 平成13年度研究報告書, 2002

  
• Effects of deep inspiration on bronchoconstriction in the rat

  T Hirai; JHT Bates

  RESPIRATION PHYSIOLOGY, Sep. 2001, Peer-reviewed

  
• COPDにおけるLAA clusterの構造に関するフラクタル解析

  MISHIMA MASAAKI; HIRAI TOYOHIRO; NAKANO YASUYUKI; NISHIMURA KOICHI; KAWAKAMI KENZO; SAKAI HIROAKI; MURO SHIGEO; SHIMIZU KOICHI; NAKAMURA TAKASHI

  日本呼吸器学会雑誌, 10 Mar. 2001

  
• Distorted trachea in patients with chronic obstructive pulmonary disease

  S Muro; Y Nakano; H Sakai; Y Takubo; Y Oku; K Chin; K Nishimura; T Hirai; K Kawakami; T Nakamura; M Mishima

  RESPIRATION, Nov. 2000, Peer-reviewed

  
• Computed tomographic measurements of airway dimensions and emphysema in smokers - Correlation with lung function

  Y Nakano; S Muro; H Sakai; T Hirai; K Chin; M Tsukino; K Nishimura; H Itoh; PD Pare; JC Hogg; M Mishima

  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Sep. 2000, Peer-reviewed

  
• COPDの胸部CTにおけるLAAの加齢変化 3年間のlongitudinal study

  三嶋 理晃; 平井 豊博; 西村 浩一; 伊藤 春海; 中野 恭幸; 阪井 宏彰; 室 繁郎; 清水 孝一; 中村 敬哉; 宮岡 史代

  日本呼吸器学会雑誌, Mar. 2000

  
• CTによるCOPDの肺気腫と気道病変の計測 (厚生省S)

  MISHIMA MASAAKI; NAKANO YASUYUKI; MURO SHIGEO; SAKAI HIROAKI; HIRAI TOYOHIRO; TSUKINO MITSUHIRO; NISHIMURA KOICHI; ITO HARUMI; NAKAMURA TAKASHI

  呼吸不全調査研究班 平成11年度研究報告書, 2000

  
• Complexity of terminal airspace geometry assessed by lung computed tomography in normal subjects and patients with chronic obstructive pulmonary disease

  M Mishima; T Hirai; H Itoh; Y Nakano; H Sakai; S Muro; K Nishimura; Y Oku; K Chin; M Ohi; T Nakamura; JHT Bates; AM Alencar; B Suki

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Aug. 1999, Peer-reviewed

  
• Age-associated changes in elastin and collagen content and the proportion of types I and III collagen in the lungs of mice

  Y Takubo; T Hirai; S Muro; K Kogishi; M Hosokawa; M Mishima

  EXPERIMENTAL GERONTOLOGY, Jun. 1999, Peer-reviewed

  
• Optimized scanning conditions of high resolution CT in the follow-up of pulmonary emphysema

  M Mishima; H Itoh; H Sakai; Y Nakano; S Muro; T Hirai; Y Takubo; K Chin; M Ohi; K Nishimura; K Yamaguchi; T Nakamura

  JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, May 1999, Peer-reviewed

  
• Comparison of low attenuation areas on computed tomographic scans between inner and outer segments of the lung in patients with chronic obstructive pulmonary disease: incidence and contribution to lung function

  Y Nakano; H Sakai; S Muro; T Hirai; Y Oku; K Nishimura; M Mishima

  THORAX, May 1999, Peer-reviewed

  
• 慢性肺気腫におけるHRCT撮像の最適条件 被曝量軽減の立場から

  三嶋 理晃; 伊藤 春海; 阪井 宏彰; 中野 恭幸; 室 繁郎; 平井 豊博; 陳 和夫; 西村 浩一; 大井 元晴

  日本呼吸器学会雑誌, Mar. 1999

  
• Acute response of the lung mechanics of the rabbit to hypoxia

  H Sakai; M Fukui; Y Nakano; K Endo; T Hirai; Y Oku; M Mishima

  JOURNAL OF APPLIED PHYSIOLOGY, Jan. 1999, Peer-reviewed

  
• Effects of lung volume on lung and chest wall mechanics in rats

  T Hirai; KA McKeown; RFM Gomes; JHT Bates

  JOURNAL OF APPLIED PHYSIOLOGY, Jan. 1999, Peer-reviewed

  
• Respiratory impedance during positive expiratory airway pressure in patients with chronic obstructive pulmonary disease.

  M Mishima; K Kawakami; T Hirai; Y Takubo; H Sakai; Y Nakano; S Muro; Y Oku; K Chin; M Ohi

  Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering, 1999, Peer-reviewed

  
• Examination of the usefulness of fractal analysis of low absorption regions in chest computerized tomography for the early diagnosis of pulmonary emphysema. ( Ministry of Health and Welfare.S ).

  MISHIMA MASAAKI; HIRAI TOYOHIRO; NAKANO YASUYUKI; SAKAI HIROAKI; MURO SHIGEO; NISHIMURA KOICHI; CHIN KAZUO; OI MOTOHARU

  呼吸器系疾患調査研究班・呼吸不全調査研究班 平成9年度研究報告書, 1998

  
• Quantitative assessment of the spatial distribution of low attenuation areas on X-ray CT using texture analysis in patients with chronic pulmonary emphysema.

  M Mishima; Y Oku; K Kawakami; N Sakai; M Fukui; T Hirai; K Chin; M Ohi; K Nishimura; H Itoh; M Tanemura; K Kuno

  Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering, 1997, Peer-reviewed

  
• Consideration on early diagnosis of juvenile pulmonary emphysema in breast computed tomograph. ( The Ministry of Health and Welfare S ).

  NAKANO YASUYUKI; SAKAI HIROAKI; MURO SHIGEO; HIRAI TOYOHIRO; CHIN KAZUO; NISHIMURA KOICHI; ITO HARUMI; HISANO KENJI; OI MOTOHARU

  呼吸器系疾患調査研究班・呼吸不全調査研究班 平成8年度研究報告書, 1997

  
• Effects of resistive load on the phase difference between chest and mouth flow in patients with chronic obstructive pulmonary disease.

  M Mishima; K Higashiya; K Kawakami; N Sugiura; N Sakai; T Hirai; Y Oku; K Chin; M Ohi; K Kuno

  Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering, 1997, Peer-reviewed

  
• Standardization of low attenuation area versus total lung area in chest X-ray CT as an indicator of chronic pulmonary emphysema.

  M Mishima; T Hirai; Z Jin; Y Oku; N Sakai; Y Nakano; H Sakai; K Chin; M Ohi; K Kawakami; K Shimada; H Itoh; K Yamaguchi; T Sawa; K Kuno

  Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering, 1997, Peer-reviewed

  
• Relationship between dyspnea in daily life and psycho-physiologic state in patients with chronic obstructive pulmonary disease during long-term domiciliary oxygen therapy

  M Mishima; Y Oku; S Muro; T Hirai; K Chin; M Ohi; M Nakagawa; M Fujita; K Sato; K Shimada; S Yamaoka; Y Oda; N Asai; Y Sagawa; K Kuno

  INTERNAL MEDICINE, Jun. 1996, Peer-reviewed

  
• Validity of a random noise oscillation and body box system for the measurement of the respiratory impedance of small animals.

  M Mishima; K Kawakami; T Fukunaga; N Sugiura; T Hirai; Y Oku; M Fukui; K Chin; M Ohi; K Kuno

  Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering, 1996, Peer-reviewed

  
• Chest flow during the initial inspiratory phase (V0.1) in pulmonary diseased patients.

  M Mishima; K Kawakami; N Sakai; T Hirai; M Fukui; Y Oku; K Chin; M Ohi; K Kuno

  Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering, 1996, Peer-reviewed

  
• Age-related changes in the static and dynamic mechanical properties of mouse lungs

  T Hirai; M Hosokawa; K Kawakami; Y Takubo; N Sakai; Y Oku; K Chin; M Ohi; K Higuchi; K Kuno; M Mishima

  RESPIRATION PHYSIOLOGY, Dec. 1995, Peer-reviewed

  
• Respiratory insufficiency research. Proposal of universal index for pulmonary emphysema lesion evaluation using breast CT. Using area ratio (LAA%) of low respiration area to whole embryonate. ( Ministry of Health and Welfare S )

  MISHIMA MASAAKI; SAKAI NAOKI; KAWAKAMI KENZO; SHIMADA KAZUE; KOSHIHISA MASATAKA; MURO SHIGEO; HIRAI TOYOHIRO; ITO HARUMI; HISANO KENJI

  呼吸不全調査研究班 平成6年度研究報告書, 1995

  
• Potential errors in measuring the phase difference between chest flow and mouth flow.

  M. Mishima; K. Kawakami; N. Sugiura; T. Fukunaga; N. Sakai; T. Hirai; K. Kuno

  Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering, 1993, Peer-reviewed

  
• Daily fluctuations of sodium valproate levels in polypharmacy - Drug-interaction between anticonvulsants

  M. Hirabayashi; T. Hirai

  Kitakanto Medical Journal, 1988, Peer-reviewed