Basic Information

Faculty

• Faculty of Engineering

Concurrent Affiliation

• Center for the Promotion of Interdisciplinary Education and Research (C-PiER), スーパーグローバルコース 化学系ユニット

Academic Degree

• 修士（工学）(京都大学)
• 博士（工学）(京都大学)

Language of Instruction

• English

ID,URL

• ORCID ID

  0000-0001-7903-4091

• J-Global ID

  201401035268647968

researchmap URL

• https://researchmap.jp/7000009366

Research

Research Topics, Overview of the research

• Research Topics

  Development of organic transformations catalyzed by dual catalysis

• Overview of the research

  Transition-metal catalyzed reaction is a powerful tool in synthetic chemistry. Most of previous reactions were catalyzed by a single catalysis. Therefore, I am trying to develop new reactions which are catalyzed by dual catalysis.

Research Areas

• Nanotechnology/Materials, Synthetic organic chemistry

Papers

• Periphery-Arranged Bulky Phosphite Ligands: Synthesis and Steric Effect in Cu-Catalyzed Hydrosilylation of Ketones

  Ibuki Satoh; Kazuhiko Semba; Jun-ya Hasegawa; Tetsuaki Fujihara

  Organometallics, 23 Jun. 2025, Peer-reviewed

  
• Regioselective α-Allylation of Cyclic Allylborates with Allylic Bromides

  Go Yamagiwa; Hiroki Murata; Kazuhiko Semba; Tetsuaki Fujihara

  The Journal of Organic Chemistry, 11 Apr. 2025, Peer-reviewed

  
• Site-Selective Magnesiation of Multifluorinated Arenes Catalyzed by Rhodium–Aluminum Bimetallic Complexes

  Ikuya Fujii; Kazuhiko Semba; Yoshiaki Nakao

  ACS Catalysis, 17 Jan. 2025, Peer-reviewed

  Access this paper :

  
• Magnesiation of Alkyl Fluorides Catalyzed by Rhodium–Aluminum Bimetallic Complexes

  Ikuya Fujii; Ryota Higo; Kazuhiko Semba; Yoshiaki Nakao

  Synlett, 28 Dec. 2023, Peer-reviewed

  
• X-Type Aluminyl Ligands for Transition-Metal Catalysis

  Naofumi Hara; Kazuhiko Semba; Yoshiaki Nakao

  ACS Catalysis, 04 Feb. 2022, Peer-reviewed

  
• Rh Complex with Unique Rh–Al Direct Bond: Theoretical Insight into its Characteristic Features and Application to Catalytic Reaction via σ-Bond Activation

  Li, Q.-Z.; Hara, N.; Semba, K.; Nakao, Y.; Sakaki, S.

  Topics in Catalysis, 2022, Peer-reviewed

  
• Synthesis and Reactivity of Heterobimetallic Co-PAlP Pincer Complexes

  Semba, K.; Shimoura, F.; Nakao, Y.

  Chemistry Letters, 2022, Peer-reviewed, Lead author

  
• The Kumada–Tamao–Corriu Coupling Reaction Catalyzed by Rhodium–Aluminum Bimetallic Complexes

  Ikuya Fujii; Kazuhiko Semba; Yoshiaki Nakao

  Organic Letters, 15 Apr. 2022, Peer-reviewed

  
• 1,2-Arylboration of aliphatic alkenes by cooperative palladium/copper catalysis

  Kazuhiko Semba; Yasuhiro Ohtagaki; Yoshiaki Nakao

  TETRAHEDRON LETTERS, May 2021, Peer-reviewed, Lead author, Corresponding author

  
• Merging Pd-0/Pd-II Redox and Pd-II/Pd-II Non-redox Catalytic Cycles for the Allylarylation of Electron-Deficient Alkenes

  Kazuhiko Semba; Naoki Ohta; Fritz Paulus; Masaki Ohata; Yoshiaki Nakao

  CHEMISTRY-A EUROPEAN JOURNAL, Mar. 2021, Peer-reviewed, Lead author, Corresponding author

  
• Magnesiation of Aryl Fluorides Catalyzed by a Rhodium-Aluminum Complex

  Ikuya Fujii; Kazuhiko Semba; Qiao-Zhi Li; Shigeyoshi Sakaki; Yoshiaki Nakao

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jul. 2020, Peer-reviewed

  
• Nickel-catalysed anti-Markovnikov hydroarylation of unactivated alkenes with unactivated arenes facilitated by non-covalent interactions

  Noam I. Saper; Akito Ohgi; David W. Small; Kazuhiko Semba; Yoshiaki Nakao; John F. Hartwig

  Nature Chemistry, 01 Mar. 2020, Peer-reviewed

  
• A PAlP pincer ligand bearing a 2-Diphenylphosphinophenoxy backbone

  Kazuhiko Semba; Ikuya Fujii; Yoshiaki Nakao

  Inorganics, 01 Dec. 2019, Peer-reviewed, Lead author

  
• Carboallylation of Electron-Deficient Alkenes with Organoboron Compounds and Allylic Carbonates by Cooperative Palladium/Copper Catalysis

  Kazuhiko Semba; Naoki Ohta; Yoshiaki Nakao

  Organic Letters, 21 Jun. 2019, Peer-reviewed, Lead author, Corresponding author

  
• Cross-coupling reactions by cooperative Pd/Cu or Ni/Cu catalysis based on the catalytic generation of organocopper nucleophiles

  Kazuhiko Semba; Yoshiaki Nakao

  Tetrahedron, 08 Feb. 2019, Peer-reviewed, Lead author, Corresponding author

  
• Pd/NHC-catalyzed cross-coupling reactions of nitroarenes

  Myuto Kashihara; Rong Lin Zhong; Kazuhiko Semba; Shigeyoshi Sakaki; Yoshiaki Nakao

  Chemical Communications, 2019, Peer-reviewed

  
• Synthesis of N-heterocyclic carbene ligands for site-selective C-H alkylation by cooperative nickel/aluminum catalysis

  Shogo Okumura; Tomohiro Ebara; Kazuhiko Semba; Yoshiaki Nakao

  Heterocycles, 2019, Peer-reviewed

  
• Rhodium Complexes Bearing PAlP Pincer Ligands

  Naofumi Hara; Teruhiko Saito; Kazuhiko Semba; Nishamol Kuriakose; Hong Zheng; Shigeyoshi Sakaki; Yoshiaki Nakao

  Journal of the American Chemical Society, 13 Jun. 2018, Peer-reviewed

  
• Site-Selective Linear Alkylation of Anilides by Cooperative Nickel/Aluminum Catalysis

  Shogo Okumura; Takuya Komine; Erika Shigeki; Kazuhiko Semba; Yoshiaki Nakao

  Angewandte Chemie - International Edition, 22 Jan. 2018, Peer-reviewed

  
• Hydrogenative cross-coupling of internal alkynes and aryl iodides by palladium/copper cooperative catalysis

  Kazuhiko Semba; Ryohei Kameyama; Yoshiaki Nakao

  Chemistry Letters, 2018, Peer-reviewed, Lead author, Corresponding author

  
• Carboallylation of electron-deficient alkenes by palladium/copper catalysis

  Kazuhiko Semba; Naoki Ohta; Yuko Yano; Yoshiaki Nakao

  Chemical Communications, 2018, Peer-reviewed, Lead author, Corresponding author

  
• How to Control Inversion vs Retention Transmetalation between Pd^II-Phenyl and Cu^I-Alkyl Complexes: Theoretical Insight

  Hong Zheng; Kazuhiko Semba; Yoshiaki Nakao; Shigeyoshi Sakaki

  Journal of the American Chemical Society, 11 Oct. 2017, Peer-reviewed

  
• Cross-coupling reactions by cooperative metal catalysis

  Kazuhiko Semba; Yoshiaki Nakao

  Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry, 2017, Peer-reviewed, Lead author, Corresponding author

  
• C3-Selective alkenylation of N-acylindoles with unactivated internal alkynes by cooperative nickel/aluminium catalysis

  Fumiyoshi Inoue; Teruhiko Saito; Kazuhiko Semba; Yoshiaki Nakao

  Chemical Communications, 2017, Peer-reviewed

  
• para-Selective C−H Borylation of (Hetero)Arenes by Cooperative Iridium/Aluminum Catalysis

  Lichen Yang; Kazuhiko Semba; Yoshiaki Nakao

  Angewandte Chemie - International Edition, 2017, Peer-reviewed

  
• Arylboration of internal alkynes by cooperative palladium/copper catalysis

  Kazuhiko Semba; Megumi Yoshizawa; Yasuhiro Ohtagaki; Yoshiaki Nakao

  Bulletin of the Chemical Society of Japan, 2017, Peer-reviewed, Lead author, Corresponding author

  
• Para-Selective Alkylation of Benzamides and Aromatic Ketones by Cooperative Nickel/Aluminum Catalysis

  Shogo Okumura; Shuwei Tang; Teruhiko Saito; Kazuhiko Semba; Shigeyoshi Sakaki; Yoshiaki Nakao

  Journal of the American Chemical Society, 09 Nov. 2016, Peer-reviewed

  
• Arylboration of 1-Arylalkenes by Cooperative Nickel/Copper Catalysis

  Kazuhiko Semba; Yasuhiro Ohtagaki; Yoshiaki Nakao

  Organic Letters, 19 Aug. 2016, Peer-reviewed, Lead author, Corresponding author

  
• Reductive cross-coupling of conjugated arylalkenes and aryl bromides with hydrosilanes by cooperative palladium/copper catalysis

  Kazuhiko Semba; Kenta Ariyama; Hong Zheng; Ryohei Kameyama; Shigeyoshi Sakaki; Yoshiaki Nakao

  Angewandte Chemie - International Edition, 17 May 2016, Peer-reviewed, Lead author, Corresponding author

  
• Silicon-based cross-coupling of aryl tosylates by cooperative palladium/copper catalysis

  Akito Ohgi; Kazuhiko Semba; Tamejiro Hiyama; Yoshiaki Nakao

  Chemistry Letters, 2016, Peer-reviewed

  
• Anti-Markovnikov Hydroheteroarylation of Unactivated Alkenes with Indoles, Pyrroles, Benzofurans, and Furans Catalyzed by a Nickel-N-Heterocyclic Carbene System

  York Schramm; Makoto Takeuchi; Kazuhiko Semba; Yoshiaki Nakao; John F. Hartwig

  Journal of the American Chemical Society, 30 Sep. 2015, Peer-reviewed

  
• Copper-catalyzed semihydrogenation of alkynes to Z -alkenes

  Kazuhiko Semba; Ryohei Kameyama; Yoshiaki Nakao

  Synlett, Feb. 2015, Peer-reviewed, Lead author, Corresponding author

  
• Arylboration of alkenes by cooperative palladium/copper catalysis

  Kazuhiko Semba; Yoshiaki Nakao

  Journal of the American Chemical Society, 28 May 2014, Peer-reviewed, Lead author, Corresponding author

  
• Intramolecular aminocyanation of alkenes by cooperative palladium/boron catalysis

  Yosuke Miyazaki; Naoki Ohta; Kazuhiko Semba; Yoshiaki Nakao

  Journal of the American Chemical Society, 12 Mar. 2014, Peer-reviewed

  
• Copper-catalyzed borylation of α-alkoxy allenes with bis(pinacolato)diboron: Efficient synthesis of 2-boryl 1,3-butadienes

  Kazuhiko Semba; Tetsuaki Fujihara; Jun Terao; Yasushi Tsuji

  Angewandte Chemie - International Edition, 18 Nov. 2013, Peer-reviewed, Lead author

  
• Highly selective copper-catalyzed hydroboration of allenes and 1,3-dienes

  Kazuhiko Semba; Masataka Shinomiya; Tetsuaki Fujihara; Jun Terao; Yasushi Tsuji

  Chemistry - A European Journal, 27 May 2013, Peer-reviewed, Lead author

  
• Copper-catalyzed silacarboxylation of internal alkynes by employing carbon dioxide and silylboranes

  Tetsuaki Fujihara; Yosuke Tani; Kazuhiko Semba; Jun Terao; Yasushi Tsuji

  Angewandte Chemie - International Edition, 12 Nov. 2012, Peer-reviewed

  
• Copper-catalyzed highly selective semihydrogenation of non-polar carbon-carbon multiple bonds using a silane and an alcohol

  Kazuhiko Semba; Tetsuaki Fujihara; Tinghua Xu; Jun Terao; Yasushi Tsuji

  Advanced Synthesis and Catalysis, 21 May 2012, Peer-reviewed, Lead author

  
• Copper-catalyzed highly regio- and stereoselective directed hydroboration of unsymmetrical internal alkynes: Controlling regioselectivity by choice of catalytic species

  Kazuhiko Semba; Tetsuaki Fujihara; Jun Terao; Yasushi Tsuji

  Chemistry - A European Journal, Apr. 2012, Peer-reviewed, Lead author

  
• Copper-catalyzed hydrocarboxylation of alkynes using carbon dioxide and hydrosilanes

  Tetsuaki Fujihara; Tinghua Xu; Kazuhiko Semba; Jun Terao; Yasushi Tsuji

  Angewandte Chemie - International Edition, 10 Jan. 2011, Peer-reviewed

  
• Copper-catalyzed hydrosilylation with a bowl-shaped phosphane ligand: Preferential reduction of a bulky ketone in the presence of an aldehyde

  Tetsuaki Fujihara; Kazuhiko Semba; Jun Terao; Yasushi Tsuji

  Angewandte Chemie - International Edition, 15 Feb. 2010, Peer-reviewed

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Misc.

• Copper-catalyzed borylative transformations of non-polar carbon-carbon unsaturated compounds employing borylcopper as an active catalyst species

  Kazuhiko Semba; Tetsuaki Fujihara; Jun Terao; Yasushi Tsuji

  Tetrahedron, Apr. 2015

  Access this misc :

  
• Copper-catalyzed borylative allyl-allyl coupling reaction

  Kazuhiko Semba; Naoto Bessho; Tetsuaki Fujihara; Jun Terao; Yasushi Tsuji

  Angewandte Chemie - International Edition, 18 Aug. 2014, Peer-reviewed

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• Regioselective transformation of alkynes catalyzed by a copper hydride or boryl copper species

  Tetsuaki Fujihara; Kazuhiko Semba; Jun Terao; Yasushi Tsuji

  Catalysis Science and Technology, Jun. 2014

  Access this misc :

  
• Dual-catalyzed transformations combining palladium/gold co-catalysis

  Kazuhiko Semba

  Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry, 2014

  

Presentations

• 協働金属触媒による有機合成

  仙波一彦

  日本化学会第104春季年会，A1423-2am-01，日本大学, 19 Mar. 2024, Invited

  
• Cross-Coupling Reactions with Alkenes as Alkylmetal Surrogates

  Kazuhiko Semba

  International Kyoto Symposium on Organic Chemistry, Kyoto, 09 Nov. 2022, Invited

  
• Catalytic Reactions by Rhodium–Aluminum Heterobimetallic Complexes

  Kazuhiko Semba

  錯体化学会第71回討論会，S4-04，オンライン, 16 Sep. 2021, Invited

  
• 触媒的に生成する有機金属反応剤を用いるクロスカップリング反応

  仙波一彦

  日本化学会第100春季年会，1H1-26，東京理科大学, 22 Mar. 2020, Invited

  
• Cross-Coupling Reactions Based on the Catalytic Generation of Organometallic Nucleophiles

  Kazuhiko Semba

  The 2nd Japanese-Sino Symposium on Catalysis for Precision Synthesis, IL-24, Kyoto, 07 Dec. 2019, Invited

  
• 触媒的に生成する有機銅種を利用するクロスカップリング反応

  仙波一彦

  第3回有機若手ワークショップ，京都大学理学研究科セミナーハウス, 07 Nov. 2018, Invited

  
• Carboboration of Alkenes by Cooperative Metal Catalysis

  Kazuhiko Semba; Yasuhiro Ohtagaki; Yoshiaki Nakao

  International Symposium on Main Group Chemistry Directed towards Organic Synthesis (MACOS), IL-05, Kyoto, 25 Aug. 2018, Invited

  
• 触媒的に生じる有機銅種を用いるクロスカップリング反応

  仙波一彦

  新学術領域研究「ハイブリッド触媒」第1回若手道場，おごと温泉湯の宿木もれび, 26 May 2018, Invited

  
• Carboboration of Alkenes and Alkynes by Cooperative Metal Catalysis

  Kazuhiko Semba

  8th International Collaborative and Cooperative Chemistry Symposium 2017 (ICCCS-8), Hyderabad, 18 Dec. 2017, Invited

  
• 多元素協働触媒による分子変換反応

  仙波一彦

  都大学テックコネクト新技術説明会2017，京都大学, 10 Mar. 2017, Invited

  
• Cross-Coupling Reactions by Cooperative Palladium/Copper Catalysis

  Kazuhiko Semba

  International Symposium on Pure & Applied Chemistry (ISPAC) 2016, ORC08, Kuching, 16 Aug. 2016, Invited

  
• パラジウム／銅協働触媒によるクロスカップリング反応

  仙波一彦

  京都コモンズ 京都大学工学研究科化学系基礎研究（有機合成）ワークショップ，京都市成長産業創造センター（ACT Kyoto）, 24 Feb. 2016, Invited

  

External funds: Kakenhi

• Carboboration of Alkenes Based on New Mechanisms

  Grant-in-Aid for Early-Career Scientists

  Basic Section 33020:Synthetic organic chemistry-related

  Kyoto University

  Kazuhiko SEMBA

  From 01 Apr. 2018, To 31 Mar. 2022, Project Closed

  カルボホウ素化反応;アルケン;アルキルホウ素化合物;メタラサイクル錯体;多置換フラン;協働触媒反応;共役付加反応;アリルアリール化;協働触媒作用;カルボホウ素化;ニッケル;パラジウム;銅;有機ホウ素化合物;遷移金属触媒

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K14213/
• Development of Reactions by Cooperative Transition-Metal Catalysis Based on Controlling Transition State of Transmetallations

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Kazuhiko Semba

  From 18 Jul. 2017, To 31 Mar. 2021, Project Closed

  トランスメタル化;協働触媒;クロスカップリング;アルケン;アリルアリール化;協働触媒反応;パラジウム;コバルト;水素化カップリング;銅;トランスメタル化反応;金属協働触媒

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17KT0098/
• Cross-Coupling Reactions Based on Catalytically Generated Organometallics via Addition of Metal Species

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  Kazuhiko Semba

  From 01 Apr. 2014, To 31 Mar. 2018, Project Closed

  クロスカップリング反応;金属協働触媒;クロスカップリング;パラジウム;銅;ヒドロアリール化;カルボホウ素化;アリールホウ素化;アルキン;アルケン;交差カップリング反応

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26810058/
• Functionalization of Unactivated Bonds by Cooperative Metal Catalysis

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Science and Engineering

  Kyoto University

  Yoshiaki NAKAO

  From 01 Apr. 2010, To 31 Mar. 2015, Project Closed

  協働金属触媒;遷移金属;ルイス酸;不活性結合;不活性結合活性化;炭素ー水素結合活性化;炭素ー炭素結合活性化;炭素ー酸素結合活性化;炭素ー窒素結合活性化;炭素-水素結合活性化;炭素-炭素結合活性化;炭素-炭素結合活性

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-22105003/
• Innovation in Preparation of Organic Fluorides by Heterobimetallic Complexes

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 33:Organic chemistry and related fields

  Kyoto University

  仙波 一彦

  From 30 Jun. 2022, To 31 Mar. 2025, Granted

  有機フッ素化合物;グリニャール反応剤;複核金属錯体触媒;複核金属錯体;炭素－フッ素結合活性化

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K19026/
• Molecular Transformations Catalyzed by Bimetallic Complexes

  Grant-in-Aid for Scientific Research (B)

  Basic Section 33020:Synthetic organic chemistry-related

  Kyoto University

  仙波 一彦

  From 01 Apr. 2024, To 31 Mar. 2028, Granted

  遷移金属複核錯体;クロスカップリング反応;C-H結合官能基化

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K01483/

Education

Teaching subject(s)

• From 01 Apr. 2025, To 31 Mar. 2026

  Organic Chemistry II (Advanced Chemistry)

  7414, Spring, Faculty of Engineering, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  ILAS Seminar

  Z001, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Organic Chemistry II (Advanced Chemistry)

  7414, Spring, Faculty of Engineering, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Organotransition Metal Chemistry 1

  H041, Spring, Graduate School of Engineering, 1.5
• From 01 Apr. 2023, To 31 Mar. 2024

  Frontier Chemistry Laboratory II(Frontier Chemistry)

  7136, Fall, Faculty of Engineering, 7
• From 01 Apr. 2023, To 31 Mar. 2024

  Frontier Chemistry Laboratory I(Frontier Chemistry)

  7135, Spring, Faculty of Engineering, 7

Administration

Faculty management (title, position)

• From 01 Apr. 2017, To 31 Mar. 2018

  桂事業場環境安全衛生委員会　委員
• From 01 Apr. 2018, To 31 Mar. 2020

  桂事業場環境安全衛生委員会　委員
• From 01 Apr. 2021, To 31 Mar. 2023

  桂事業場環境安全衛生委員会　委員