Basic Information

Faculty

• 医学部

Academic Degree

• 修士（生命科学）(京都大学)
• 博士（生命科学）(京都大学)

Academic Resume (Undergraduate School/Majors)

• 京都大学, 理学部理学科, 卒業

ID,URL

• J-Global ID

  201901010699474240

researchmap URL

• https://researchmap.jp/nobuyuki_tanimura

Research

Research Areas

• Life sciences, Cell biology

Papers

• Mechanical imbalance between normal and transformed cells drives epithelial homeostasis through cell competition.

  Praver Gupta; Sayantani Kayal; Nobuyuki Tanimura; Shilpa P Pothapragada; Harish K Senapati; Padmashree Devendran; Yasuyuki Fujita; Dapeng Bi; Tamal Das

  bioRxiv : the preprint server for biology, 22 Jun. 2024

  
• Navigating Transcriptional Coregulator Ensembles to Establish Genetic Networks: A GATA Factor Perspective

  A. W. DeVilbiss; N. Tanimura; S. C. McIver; K. R. Katsumura; K. D. Johnson; E. H. Bresnick

  Current Topics in Developmental Biology, 2016

  
• Accumulation of annexin A2 and S100A10 prevents apoptosis of apically delaminated, transformed epithelial cells.

  Shoko Ito; Keisuke Kuromiya; Miho Sekai; Hiroaki Sako; Kazuhito Sai; Riho Morikawa; Yohei Mukai; Yoko Ida; Moe Anzai; Susumu Ishikawa; Kei Kozawa; Takanobu Shirai; Nobuyuki Tanimura; Kenta Sugie; Junichi Ikenouchi; Motoyuki Ogawa; Isao Naguro; Hidenori Ichijo; Yasuyuki Fujita

  Proceedings of the National Academy of Sciences of the United States of America, 24 Oct. 2023

  
• Basal extrusion of single‐oncogenic mutant cells induces dome‐like structures with altered microenvironments

  Takanobu Shirai; Miho Sekai; Kei Kozawa; Nanami Sato; Nobuyuki Tanimura; Shunsuke Kon; Tomohiro Matsumoto; Takeru Murakami; Shoko Ito; Andrew Tilston‐Lunel; Xaralabos Varelas; Yasuyuki Fujita

  Cancer Science, 30 Aug. 2022

  
• Epithelial defense against cancer (EDAC).

  Tanimura N; Fujita Y

  Seminars in cancer biology, Jul. 2019, Peer-reviewed

  
• Calcium sparks enhance the tissue fluidity within epithelial layers and promote apical extrusion of transformed cells

  Keisuke Kuromiya; Kana Aoki; Kojiro Ishibashi; Moe Yotabun; Miho Sekai; Nobuyuki Tanimura; Sayuri Iijima; Susumu Ishikawa; Tomoko Kamasaki; Yuki Akieda; Tohru Ishitani; Takashi Hayashi; Satoshi Toda; Koji Yokoyama; Chol Gyu Lee; Ippei Usami; Haruki Inoue; Ichigaku Takigawa; Estelle Gauquelin; Kaoru Sugimura; Naoya Hino; Yasuyuki Fujita

  Cell Reports, Jul. 2022

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• Extracellular ATP facilitates cell extrusion from epithelial layers mediated by cell competition or apoptosis

  Yusuke Mori; Naoka Shiratsuchi; Nanami Sato; Azusa Chaya; Nobuyuki Tanimura; Susumu Ishikawa; Mugihiko Kato; Ikumi Kameda; Shunsuke Kon; Yukinari Haraoka; Tohru Ishitani; Yasuyuki Fujita

  Current Biology, May 2022, Peer-reviewed

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• FBP17-mediated finger-like membrane protrusions in cell competition between normal and RasV12-transformed cells

  Tomoko Kamasaki; Yumi Miyazaki; Susumu Ishikawa; Kazuya Hoshiba; Keisuke Kuromiya; Nobuyuki Tanimura; Yusuke Mori; Motosuke Tsutsumi; Tomomi Nemoto; Ryota Uehara; Shiro Suetsugu; Toshiki Itoh; Yasuyuki Fujita

  iScience, Aug. 2021

  
• The CD44/COL17A1 pathway promotes the formation of multilayered, transformed epithelia

  Kei Kozawa; Miho Sekai; Kenji Ohba; Shoko Ito; Hiroaki Sako; Takeshi Maruyama; Mai Kakeno; Takanobu Shirai; Keisuke Kuromiya; Tomoko Kamasaki; Koki Kohashi; Shinya Tanaka; Susumu Ishikawa; Nanami Sato; Shota Asano; Hironori Suzuki; Nobuyuki Tanimura; Yohei Mukai; Noriko Gotoh; Mishie Tanino; Shinya Tanaka; Ken Natsuga; Tomoyoshi Soga; Tomonori Nakamura; Yukihiro Yabuta; Mitinori Saitou; Takahiro Ito; Kenkyo Matsuura; Makoto Tsunoda; Toyone Kikumori; Tadashi Iida; Yasuyuki Mizutani; Yuki Miyai; Kozo Kaibuchi; Atsushi Enomoto; Yasuyuki Fujita

  Current Biology, Jun. 2021

  
• Discovering How Heme Controls Genome Function Through Heme-omics

  Ruiqi Liao; Ye Zheng; Xin Liu; Yuannyu Zhang; Gretchen Seim; Nobuyuki Tanimura; Gary M. Wilson; Peiman Hematti; Joshua J. Coon; Jing Fan; Jian Xu; Sunduz Keles; Emery H. Bresnick

  Cell Reports, Jun. 2020, Peer-reviewed

  
• Calcium Wave Promotes Cell Extrusion.

  Yasuto Takeuchi; Rika Narumi; Ryutaro Akiyama; Elisa Vitiello; Takanobu Shirai; Nobuyuki Tanimura; Keisuke Kuromiya; Susumu Ishikawa; Mihoko Kajita; Masazumi Tada; Yukinari Haraoka; Yuki Akieda; Tohru Ishitani; Yoichiro Fujioka; Yusuke Ohba; Sohei Yamada; Yoichiroh Hosokawa; Yusuke Toyama; Takaaki Matsui; Yasuyuki Fujita

  Current biology : CB, 24 Feb. 2020, Peer-reviewed

  
• GATA/Heme Multi-omics Reveals a Trace Metal-Dependent Cellular Differentiation Mechanism

  Nobuyuki Tanimura; Ruiqi Liao; Gary M. Wilson; Matthew R. Dent; Miao Cao; Judith N. Burstyn; Peiman Hematti; Xin Liu; Yuannyu Zhang; Ye Zheng; Sunduz Keles; Jian Xu; Joshua J. Coon; Emery H. Bresnick

  Developmental Cell, Sep. 2018, Peer-reviewed

  
• GATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell Regeneration and Survival in Severe Anemia

  Kyle J. Hewitt; Koichi R. Katsumura; Daniel R. Matson; Prithvia Devadas; Nobuyuki Tanimura; Alexander S. Hebert; Joshua J. Coon; Jin-Soo Kim; Colin N. Dewey; Sunduz Keles; Siyang Hao; Robert F. Paulson; Emery H. Bresnick

  DEVELOPMENTAL CELL, Aug. 2017, Peer-reviewed

  
• Mechanism governing heme synthesis reveals a GATA factor/heme circuit that controls differentiation

  Nobuyuki Tanimura; Eli Miller; Kazuhiko Igarashi; David Yang; Judith N. Burstyn; Colin N. Dewey; Emery H. Bresnick

  EMBO REPORTS, Feb. 2016, Peer-reviewed

  
• Stemness-related Factor Sall4 Interacts with Transcription Factors Oct-3/4 and Sox2 and Occupies Oct-Sox Elements in Mouse Embryonic Stem Cells

  Nobuyuki Tanimura; Motoki Saito; Miki Ebisuya; Eisuke Nishida; Fuyuki Ishikawa

  JOURNAL OF BIOLOGICAL CHEMISTRY, Feb. 2013, Peer-reviewed

  

Misc.

• Mechanism Governing Heme Synthesis Reveals a GATA Factor-Heme Circuit That Controls Differentiation

  Emery H. Bresnick; Nobuyuki Tanimura; Eli Miller; Kazuhiko Igarashi; David T. Yang; Judith Burstyn; Colin Dewey

  BLOOD, Dec. 2015

  
• LINKING HEME BIOSYNTHESIS WITH A GATA FACTOR-REGULATED GENETIC NETWORK THAT CONTROLS CELLULAR DIFFERENTIATION

  Nobuyuki Tanimura; Eli Miller; Kazuhiko Igarashi; Judith N. Burstyn; Colin N. Dewey; Emery H. Bresnick

  EXPERIMENTAL HEMATOLOGY, Sep. 2015

  

External funds: Kakenhi

• Mechanisms of the elimination of senescent cells through cell competition

  Grant-in-Aid for Early-Career Scientists

  Basic Section 44010:Cell biology-related

  Kyoto University

  Nobuyuki Tanimura

  From 01 Apr. 2020, To 31 Mar. 2023, Project Closed

  細胞競合;細胞老化;上皮細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K15785/