Basic Information

Professional Memberships

• From Apr. 1994, To Present

  日本免疫学会

Academic Degree

• 1988

  歯学博士

Academic Resume (Graduate Schools)

• 大阪大学, 歯学研究科, 歯学基礎系, 歯学博士

Research History

• From Apr. 2025, To Present

  Kyoto University, Graduate School of Medicine, Research associate
• From Apr. 2019, To Mar. 2025

  Hiroshima University, Graduate School of Biomedical & Health Sciences, Professor
• From 01 Apr. 2002, To 31 Mar. 2019

  Hiroshima University, Graduate School of Biomedical Sciences, Professor
• From Jun. 1996, To Mar. 2002

  大阪大学 微生物病研究所, 講師
• From Oct. 1991, To May 1996

  大阪大学 歯学部, 助手
• From Apr. 1988, To Sep. 1991

  国立予防衛生研究所, 厚生技官

Profile

• Profile

  My research interest is mucosal immunity.

ID,URL

• J-Global ID

  201801018542115453

• Researcher number

  20206791

researchmap URL

• https://researchmap.jp/7000028368

Research

Research Topics, Overview of the research

• Research Topics

  mucosal immunity

• Overview of the research

  molecular basis of host-symbiotic microbe interaction in tissue resident macrophages

Research Interests

• immunometabolism
• tissue resident macrophage
• Persistent symbiotic colonization of tissue resident macrophages with commensal bacteria
• Innate inflammation in the intestinal mucosa
• Mucosal Immunity

Research Areas

• Life sciences, Immunology

Papers

• Oral administration of bovine lactoferrin suppresses the progression of rheumatoid arthritis in an SKG mouse model

  Shunryou Yanagisawa; Karin Nagasaki; Chanbora Chea; Toshinori Ando; Nurina Febriyanti Ayuningtyas; Toshihiro Inubushi; Atsushi Ishikado; Hiromichi Imanaka; Eiji Sugiyama; Ichiro Takahashi; Mutsumi Miyauchi; Takashi Takata

  PLOS ONE, Feb. 2022, Peer-reviewed

  
• 

  Persistent colonization of non-lymphoid tissue-resident macrophages by Stenotrophomonas maltophilia.

  Takahashi I; Hosomi K; Nagatake T; Toubou H; Yamamoto D; Hayashi I; Kurashima Y; Sato S; Shibata N; Goto Y; Maruyama F; Nakagawa I; Kuwae A; Abe A; Kunisawa J; Kiyono H

  Int Immunol, Feb. 2020, Peer-reviewed, Lead author

  Access this paper :

  
• Analysis of hypoxia-associated dendritic cells in colitic mice and effects of probiotics on IL-10 production in inflammatory dendritic-cells under hypoxia.

  T. Ogita; J. Miyamoto; Y. Hirabayashi; M. Rossi; G. Mazzarella; I. Takahashi; S. Tanabe; T. Suzuki

  Beneficial Microbes, 2019, Peer-reviewed

  
• 粘膜免疫システム「基礎の基礎」

  高橋一郎; 長竹貴広; 清野宏

  細胞工学, 2011, Peer-reviewed, Invited, Lead author

  
• Mucosal regulatory cells in the gastrointestinal tract and periodontium

  Takakashi, I; Fujihashi, K; Kiyono, H

  Periodontology 2000, 2010, Peer-reviewed, Invited, Lead author

  
• The mucosal immune system for secretory IgA responses and mucosal vaccine development

  Takahashi, I; Nochi, T; Yuki, Y; Kunisawa, J; Kiyono, H

  Inflammation and Regeneration, 2010, Peer-reviewed, Invited, Lead author

  
• New horizon of mucosal immunity and vaccines

  Ichiro Takahashi; Tomonori Nochi; Yoshikazu Yuki; Hiroshi Kiyono

  CURRENT OPINION IN IMMUNOLOGY, Jun. 2009, Peer-reviewed, Lead author

  
• Intraepithelial lymphocytes: their shared and divergent immunological behaviors in the small and large intestine

  Jun Kunisawa; Ichiro Takahashi; Hiroshi Kiyono

  IMMUNOLOGICAL REVIEWS, Feb. 2007, Peer-reviewed

  
• The ying and yang of the mucosal immune system

  Takahashi, I

  Journal of Japanese Society for Helicobacter Research, 2006, Peer-reviewed, Invited, Lead author, Corresponding author

  
• Colitis in mice lacking the common cytokine receptor gamma chain is mediated by IL-6-producing CD4+ T cells

  Kai, Y; I. Takahashi; H. Ishikawa; T. Hiroi; T. Mizushima; D. Kishi; H. Hamada; H. Tamagawa; T. Ito; K. Yoshizaki; T. Kishimoto; H. Matsuda; H. Kiyono

  Gastroenterology, 2005, Peer-reviewed

  
• 粘膜ワクチン

  高橋一郎

  日本臨床, 2005, Invited, Lead author

  
• MICA強制発現による腸管液性免疫応答機構への影響

  島津 篤; 高 明善; 柳原 琢磨; 桐戸 真美; 清野 宏; 高橋 一郎

  日本免疫学会総会・学術集会記録, Nov. 2004

  
• Characteristics of claudin expression in follicle-associated epithelium of Peyer's patches: Preferential localization of claudin-4 at the apex of the dome region

  Tamagawa, H; Takahashi, I; Furuse, M; Yoshitake-Kitano, Y; Tsukita, S; Ito, T; Matsuda, H; Kiyono, H

  LABORATORY INVESTIGATION, Jul. 2003, Peer-reviewed

  
• Development of colitis in STAT6-deficient TCR alpha chain deficient mice:A potential role of STAT6-independent IL-4 signaling for the generation of Th2-biased pathologic CD4+beta/beta+ T cells.

  Okuda, Y.; I. Takahashi; J. Kim; N. Ohta; K. Iwatani; H. Iijima; Y. Kai; H. Tamagawa; T. Hiroi; S. Kawano; Y. Sasaki; M. Hori; K. Takeda; S. Akira; H. Kiyono.

  American Journal of Pathology, 2003, Peer-reviewed

  
• Clonal expansion of double-positive IELs by MICA expressed in mouse small intestinal epithelium.

  Eun Jeong Park; Ichiro Takahashi; Junko Ikeda; Kazuko Kawahara; Tetsuji Okamoto; Mi-Na Kweon; Satoshi Fukuyama; Veronika Groh; Thomas Spies; Yuichi Obata; Jun-Ichi Miyazaki; Hiroshi Kiyono

  Journal of Immunology, 2003, Peer-reviewed

  
• Induction of cytotoxic T lymphocyte responses by cholera toxin-treated bone marrow-derived dendritic cells.

  Jang, MH; Kweon, MN; Hiroi, T; Yamamoto, M; Takahashi, I; Kiyono, H

  Vaccine, 2003, Peer-reviewed

  
• Lack of antigen-specific immune responses in anti-IL-7 receptor alpha chain antibody-treated Peyer's patch-null mice following intestinal immunization with microencapsulated antigen.

  Kunisawa J; Takahashi I; Okudaira A; Hiroi T; Katayama K; Ariyama T; Tsutsumi Y; Nakagawa S; Kiyono H; Mayumi T

  European Journal of Immunology, Aug. 2002, Peer-reviewed

  
• Development of antigen induced colitis in SCID mice reconstituted with spleen derived memory type CD4+ CD45RB+ T cells.

  Kweon, MN; Yamamoto, M; Takahashi, I; Kiyono, H

  Gut, 2002, Peer-reviewed

  
• 粘膜免疫担当組織細胞の特殊性と炎症性腸疾患．

  高橋一郎; 朴恩正; 清野宏

  Molecular Medicine, 2002, Invited, Lead author

  
• Colitis-related public T cells are selected in the colonic lamina propria of IL-10-deficient mice.

  Takahashi, I; Matsuda, J; Gapin, L; De Winter H; Kai, Y; Tamagawa, H; Kronenberg, M; Kiyono, H

  Clinical Immunology, 2002, Peer-reviewed, Lead author

  
• Regulation of mucosal immune responses by recombinant interleukin 10 produced by intestinal epithelial cells in mice.

  De Winter, H; D. Elewaut; O. Turovskaya; M. Huflejt; C. Shimeld; A. Hagenbaugh; S. Binder; I. Takahashi; M. Kronenberg; H. Cheroutre

  Gastroenterology, 2002, Peer-reviewed

  
• Sendai virus fusion protein mediates simultaneous induction of MHC class I/II-dependent mucosal and systemic immune responses via the nasopharyngeal-associated lymphoreticular tissue immune system.

  Kunisawa J; Nakanishi T; Takahashi I; Okudaira A; Tsutsumi Y; Katayama K; Nakagawa S; Kiyono H; Mayumi T

  J Immunol, Aug. 2001, Peer-reviewed

  
• The mucosal immune system: From specialized immune defense to inflammation and allergy

  Hiroshi Kiyono; M. N. Kweon; T. Hiroi; I. Takahashi

  Acta Odontologica Scandinavica, Jun. 2001

  
• 経鼻薬物キャリアーとしての膜融合リポソームの機能評価と経鼻ワクチンへの応用

  國澤 純; 有山 輝子; 奥平 章子; 形山 和史; 増田 幸史; 中西 剛; 中川 晋作; 真弓 忠範; 高橋 一郎; 清野 宏

  薬剤学: 生命とくすり, Mar. 2001

  
• New insights into mechanism of inflammatory and allergic diseases in mucosal tissues

  Mi-Na Kweon; Ichiro Takahashi; Hiroshi Kiyono

  Digestion, 2001

  
• Mucosal immune network in the gut for the control of infectious diseases

  Iijima, H; I. Takahashi; H. Kiyono

  Reviews in Medical Virology, 2001, Peer-reviewed

  
• Protective immunity to Streptococcus mutans induced by nasal vaccination with surface protein antigen and mutant cholera toxin adjuvant

  Saito M; S. Otake; M. Ohmura; M. Hirasawa; K. Takada; J. Mega; I. Takahashi; H. Kiyono; J.R. McGhee; Y. Takeda; M; Yamamoto

  J. Infect. Dis., 2001, Peer-reviewed

  
• T cell receptor dynamism of mucosal and systemic CD4+ T cells in the course of an immune response to Escherichia coli heat-labile enterotoxin.

  Kim, J; I. Takahashi; Y. Okuda; M. Itakura; J.R. McGhee; H. Kiyono.

  Journal of Infectious Diseases, 2001, Peer-reviewed

  
• Nasal administration of cholera toxin (CT) suppresses clinical signs of experimental autoimmune encephalomyelitis (EAE).

  Yura, M; I. Takahashi; S. Terawaki; T. Hiroi; M. Kweon; Y. Yuki; H. Kiyono

  Vaccine, 2001, Peer-reviewed

  
• Role of MOG-stimulated Th1 type "light up" (GFP+) CD4+ T cells for the development of experimental autoimmune encephalomyelitis (EAE).

  Yura, M; I. Takahashi; M. Serada; T. Koshio; K. Nakagami; Y. Yuki; H. Kiyono

  Journal of Autoimmunity, 2001, Peer-reviewed

  
• Influence of enterotoxin on mucosal intranet: selective inhibition of extrathymic T cell development in intestinal intraepithelial lymphocytes by oral exposure to heat-labile toxin.

  Kim, J; I. Takahashi; Y. Kai; H. Kiyono

  European Journal of Immunology, 2001, Peer-reviewed

  
• Characterization of mucoadhesive microspheres for the induction of mucosal and systemic immune responses.

  Kunisawa J; Okudaira A; Tsutusmi Y; Takahashi I; Nakanishi T; Kiyono H; Mayumi T

  Vaccine, Oct. 2000, Peer-reviewed

  
• Enterotoxin adjuvants have direct effects on T cells and antigen-presenting cells that result in either interleukin-4-dependent or –independent immune responses

  Yamamoto, M; H. Kiyono; M. Kweon; S. Yamamoto; K. Fujihashi; H. Kurazono; K. Imaoka; H. Bluethmann; I. Takahashi; Y. Takeda; M. Azuma; J.R. McGhee

  Journal of Infectious Diseases, 2000, Peer-reviewed

  
• Alteration of V-beta usage and cytokine production of CD4+TCR beta/beta homodimer T cells by elimination of Bacteroides vulgatus prevents colitis in TCR alpha-chain deficient mice.

  Kishi, D; I. Takahashi; Y. Kai; H. Tamagawa; H. Iijima; S. Obunai; R. Nezu; T. Ito; H. Matsuda; H. Kiyono

  Journal of Immunology, 2000, Peer-reviewed

  
• Systemically derived large intestinal CD4+Th2 cells play a central role in STAT6-mediated allergic diarrhea.

  Kweon, M; M. Yamamoto; M. Kajiki; I. Takahashi; H. Kiyono

  Journal of Clinical Investigation, 2000, Peer-reviewed

  
• Gut as the largest immunologic tissue

  Ichiro Takahashi; Hiroshi Kiyono

  Journal of Parenteral and Enteral Nutrition, 01 Sep. 1999

  
• Strategies for mucosal vaccine development

  PN Boyaka; M Marinaro; JL Vancott; Takahashi, I; K Fujihashi; M Yamamoto; FW van Ginkel; RJ Jackson; H Kiyono; McGhee, JR

  AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, Apr. 1999, Peer-reviewed

  
• Oligoclonal Th2-biased beta beta T cells induce murine inflammatory bowel disease

  Takahashi, I; H Iijima; D Kishi; H Kiyono

  IMMUNOLOGIC RESEARCH, 1999, Peer-reviewed

  
• Clonal expansion of CD4+TCR-beta/beta+ T cells in TCR alpha-chain deficient mice by gut-derived antigens.

  Takahashi, I; H. Iijima; R. Katashima; M. Itakura; H. Kiyono

  Journal of Immunology, 1999, Peer-reviewed, Lead author

  
• Alteration of interleukin 4 production results in the inhibition of T helper type 2 cell-dominated inflammatory bowel disease in T cell receptor alpha chain-deficient mice.

  Iijima, H; I. Takahashi; D. Kishi; J. Kim; S. Kawano; M. Hori; H. Kiyono

  Journal of Experimental Medicine, 1999, Peer-reviewed

  
• Induction of EAE by Th1-type, GFP+ MOG-specific T cells in C57BL/6 mice

  Mamoru Yura; Masashi Serada; Ichiro Takahashi; Hiroshi Kiyono; Takehiro Koshio; Keiji Nakagami; Masahito Ikawa; Masaru Okabe

  Japanese Journal of Clinical Immunology, 1998, Peer-reviewed

  
• Gamma/delta T cells: Bodyguards and/or sleepers in the gut.

  Takahashi, I; Kiyono, H

  Chemical Immunology, 1998, Peer-reviewed, Invited, Lead author

  
• Orally administered cholera toxin prevents murine intestinal T cells from staphylococcal enterotoxin B-induced anergy.

  Iijima, H; I. Takahashi; T. Hiroi; M. Shimaoka; S. Kawano; K. Nagano; M. Hori; H. Kiyono

  Gastroenterology, 1998, Peer-reviewed

  
• CD4+ T-cell population mediates development of inflammatory bowel disease in T-cell receptor alpha chain-deficient mice.

  Takahashi, I; H. Kiyono; S. Hamada

  Gastroenterology, 1997, Peer-reviewed, Lead author

  
• Role of alpha/beta T cells and gamma/delta T cells in protective immunity to Actinobacillus actinomycetemcomitans in mutant mice targeted gene disruption

  Takahashi, I; I. Nakagawa; L. Xu; S. Hamada

  Journal of Periodontal Research, 1996, Peer-reviewed, Lead author

  
• Gamma/delta T cell-deficient mice have impaired mucosal immunoglobulin A responses

  Fujihashi, K; J.R. McGhee; M. Kweon; M.D. Cooper; S. Tonegawa; I. Takahashi; T. Hiroi; J. Mestecky; H. Kiyono

  J Exp Med, 1996, Peer-reviewed

  
• Oral immunization with B subunit of the heat-labile enterotoxin of Escherichia coli induces early Th1 and late Th2 cytokine expression in Peyer's patches.

  Nakagawa, I; I. Takahashi; H. Kiyono; J.R. McGhee; S. Hamada

  Journal of Infectious Diseases, 1996, Peer-reviewed

  
• Mechanisms for mucosal immunogenicity and adjuvancy of Escherichia coli labile toxin.

  Ichiro Takahashi; Mariarosaria Marinaro; Hiroshi Kiyono; Raymond J. Jackson; Ichiro Nakagawa; Kohtaro Fujihashi; Shigeyuki Hamada; John D. Clements; Kenneth L. Bost; Jerry R. McGhee

  Journal of Infectious Diseases, 1996, Peer-reviewed, Lead author

  
• IL-12 rescues galactosamine-loaded mice from lethal shock triggered by staphylococcal enterotoxin.

  Takahashi, I; I. Nakagawa; L. Xu; S. Hamada

  Biochem. Biophys. Res. Commun., 1995, Peer-reviewed

  
• Mucosal T cells induce systemic anergy for oral tolerance.

  Ichiro Takahashi; Ichiro Nakagawa; Hiroshi Kiyono; Jerry R. McGhee; John D. Clements; Shigeyuki Hamada

  Biochem. Biophys. Res. Commun., 1995, Peer-reviewed, Lead author

  
• REGULATION OF IMMUNOGLOBULIN-A RESPONSES FOR ORAL MUCOSAL IMMUNITY

  T HIROI; H KIYONO; K FUJIHASHI; J MEGA; TAKAHASHI, I; S MORISHIMA; T FUJIWARA; S HAMADA; MCGHEE, JR

  MOLECULAR PATHOGENESIS OF PERIODONTAL DISEASE, 1994, Peer-reviewed

  
• MOLECULAR AND IMMUNOLOGICAL CHARACTERIZATION OF THE FIMBRIAE OF PORPHYROMONAS-GINGIVALIS

  S HAMADA; T FUJIWARA; S MORISHIMA; I TAKAHASHI; I NAKAGAWA; S KIMURA; T OGAWA

  MICROBIOLOGY AND IMMUNOLOGY, 1994, Peer-reviewed

  
• Mucosal immunity to infection with implications for vaccine development

  Staats, H. F; R. J. Jackson; M. Marinaro; I. Takahashi; H. Kiyono; J. R. McGhee

  Current Opinion in Immunology, 1994, Peer-reviewed

  
• Inconsistency between the fimbrilin gene and the antigenicity of lipopolysaccharides in selected strains of Porphyromonas gingivalis.

  Fujiwara T; I. Nakagawa; S. Morishima; I. Takahashi; S. Hamada

  FEMS Microbiol. Lett., 1994, Peer-reviewed

  
• Molecular cloning and sequencing of the fimbrilin gene of Porphyromonas gingivalis strains and characterization of recombinant proteins.

  Fujiwara, T; S. Morishima; I. Takahashi; S. Hamada

  Biochem. Biophys. Res. Commun., 1993, Peer-reviewed

  
• Identification of antigenic epitopes in an alanine-rich repeating region of a surface protein antigen of Streptococcus mutans.

  Okahashi, N; I. Takahashi; M. Nakai; H. Senpuku; T. Nisizawa; T. Koga

  Infection and Immunity, 1993, Peer-reviewed

  
• Molecular characterization of a negative regulator of Streptococcus sobrinus surface protein antigen gene.

  Takahashi, I; N. Okahashi; S. Hamada

  Journal of Bacteriology, 1993, Peer-reviewed, Lead author

  
• Genetic control of immune responses in mice to synthetic peptides of a Streptococcus mutans surface protein antigen.

  TAKAHASHI I

  Infection and Immunity, 1992, Peer-reviewed, Lead author

  
• INTRANASAL IMMUNIZATION WITH A RECOMBINANT PROTEIN AND SYNTHETIC PEPTIDES OF A STREPTOCOCCUS-MUTANS SURFACE PROTEIN ANTIGEN

  T KOGA; TAKAHASHI, I; N OKAHASHI

  FRONTIERS OF MUCOSAL IMMUNOLOGY, VOL 1, 1991, Peer-reviewed

  
• Complete nucleotide sequence of the gene for a surface protein antigen of Streptococcus sobrinus.

  Tokuda, M; N. Okahashi; I. Takahashi; M. Nakai; S. Nagaoka; M. Kawagoe; T. Koga

  Infect. Immun., 1991, Peer-reviewed

  
• Immunogenicity and protective effect against oral colonization by Streptococcus mutans of synthetic peptides of a streptococcal surface protein antigen.

  TAKAHASHI I

  Journal of Immunology, 1991, Peer-reviewed, Lead author

  
• Construction of a Not I restriction map of the Streptococcus mutans genome.

  Okahashi, N; C. Sasakawa; N. Okada; M. Yamada; M. Yoshikawa; M. Tokuda; I. Takahashi; T. Koga

  Journal General Microbiology, 1990, Peer-reviewed

  
• Surface hydrophobicity, adherence, and aggregation of cell surface protein antigen mutants of Streptococcus mutans serotype c.

  Koga, T; N. Okahashi; I. Takahashi; T. Kanamoto; H. Asakawa; M. Iwaki

  Infection and Immunity, 1990, Peer-reviewed

  
• Oral immunization with recombinant Streptococcus lactis containing Streptococcus mutans surface protein antigen gene.

  Iwaki, M; N. Okahashi; I. Takahashi; T. Kanamoto; Y. Sugita-Konishi; K. Aibara; T. Koga

  Infection and Immunity, 1990, Peer-reviewed

  
• Intranasal immunization of mice with recombinant protein antigen of serotype c Streptococcus mutans and cholera toxin B subunit.

  TAKAHASHI I

  Archives of Oral biology, 1990, Peer-reviewed, Lead author

  
• Effect of subculturing on expression of a cell-surface protein antigen by Streptococcus mutans.

  Koga, T; H. Asakawa; N. Okahashi; I. Takahashi

  Journal General Microbiology, 1989, Peer-reviewed

  
• Characterization of a cell-surface protein antigen of hydrophilic Streptococcus mutans strain GS-5.

  Ohta, H; H. Kato; N. Okahashi; I. Takahashi; S. Hamada; T. Koga

  Journal General Microbiology, 1989, Peer-reviewed

  
• Homology between surface protein antigen genes of Streptococcus sobrinus and Streptococcus mutans.

  Takahashi, I; N. Okahashi; C. Sasakawa; M. Yoshikawa; S. Hamada; T. Koga

  FEBS Letters, 1989, Peer-reviewed, Lead author

  
• Structural requirements of lipid A species in activation of clotting enzymes from the horseshoe crab, and the human complement cascade.

  Takada, H; S. Kotani; S. Tanaka; T. Ogawa; I. Takahashi; M. Tsujimoto; T. Komuro; T. Shiba; S. Kusumoto; N. Kusunose; A. Hasegawa; M. Kiso

  Eur. J. Biochem., 1988, Peer-reviewed

  
• Structural requirements of endotoxic lipopolysaccharides and bacterial cell walls in induction of interleukin-1.

  Takahashi, I.; S. Kotani; H. Takada; T. Shiba; S. Kusumoto.

  Blood Purification, 1988, Peer-reviewed, Lead author

  
• A novel immunomodulator derived from Mycobacterium bovis BCG which holds many bioactivities in common with endotoxins

  T. Ikeda-Fujita; S. Kotani; M. Tsujimoto; T. Ogawa; H. Takada; I. Takahashi; H. Shimauchi; S. Kokeguchi; K. Kato; H. Okamura

  Japanese Journal of Bacteriology, 1987, Peer-reviewed

  
• Possible existence of a novel amphipathic immunostimulator in the phenol-water extracts of Mycobacteriaceae

  Ikeda-Fujita, T; S. Kotani; M. Tsujimoto; T. Ogawa; I. Takahashi; H. Takada; H. Shimauchi; S. Nagao; S. Kokeguchi; K. Kato; I. Yano; H. Okamura; T. Tamura; K. Harada; H. Usami; A. Yamamoto; S. Tanaka; Y. Kato

  Microbiology and Immunology, 1987, Peer-reviewed

  
• Requirement of a properly acylated beta(1-6)-D-glucosamine disaccharide bisphosphate structure for efficientmanifestation of full endotoxic and associated bioactivities of lipid A.

  Takahashi, I.; S. Kotani, H. Takada; M. Tsujimoto; T. Ogawa; T. Shiba; S. Kusumoto; M. Yamamoto; A. Hasegawa; M. Kiso; S. Tanaka; H. Okamura; T. Tamura.

  Infection and Immunity, 1987, Peer-reviewed, Lead author

  
• Immunobiological activities of synthetic lipid A analogs with low endotoxicity.

  Kotani, S; H. Takada; I. Takahashi; T. Ogawa; M. Tsujimoto; H. Shimauchi; T. Ikeda; H. Okamura; T. Tamura; K. Harada; S. Tanaka; T. Shiba; S. Kusumoto; T. Shimamoto

  Infection and Immunity, 1986, Peer-reviewed

  
• Low endotoxic activities of synthetic Salmonella-type lipid A with an additional acyloxyacyl group on the 2-amino group of beta(1-6)glucosamine 1,4'-bisphosphate.

  Kotani, S; H. Takada; I. Takahashi; M. Tsujimoto; T. Ogawa; T. Ikeda; K. Harada; H. Okamura; T. Tamura; S. Tanaka; T. Shiba; S. Kusumoto; M. Imoto; H. Yoshimura; N. Kasai

  Infection and Immunity, 1986, Peer-reviewed

  
• Synthetic lipid A with endotoxic and related biological activities comparable to those of a natural lipid A from an Escherichia coli Re-mutant.

  Kotani, S; H. Takada; M. Tsujimoto; T. Ogawa; I. Takahashi; T. Ikeda; K. Otsuka; H. Shimauchi; N. Kasai; J. Mashimo; S. Nagao; A. Tanaka; S. Tanaka; K. Harada; K. Nagaki; H. Kitamura; T. Shiba; S. Kusumoto; M. Imoto; H. Yoshimura

  Infection and Immunity, 1985, Peer-reviewed

  
• Immunopharmacological activities of a synthetic counterpart of a biosynthetic lipid A precursor molecule;of its analogs

  Takada, H; S. Kotani; M. Tsujimoto; T. Ogawa; I. Takahashi; K. Harada; C. Katsukawa; S. Tanaka; T. Shiba; S. Kusumoto; M. Imoto; H. Yoshimura; M. Yamamoto; T. Shimamoto

  Infect. Immun, 1985, Peer-reviewed

  

Misc.

• ストレス侵襲に対する適応現象としての粘膜免疫

  高橋一郎

  炎症と免疫, 2007, Invited, Lead author

  
• 構成性MICA発現は消化管における体液性免疫応答を増強する(Constitutive MICA Expression Enhances Humoral Immune Surveillance in the Gastrointestinal Tissue)

  Shimazu Atsushi; Park Eun Jeong; Tsuruda Keiko; Koh Myongsun; Kiyono Hiroshi; Takahashi Ichiro

  日本免疫学会総会・学術集会記録, Nov. 2006

  
• 腸管上皮杯細胞によるRAE-1 mRNAのin situ発現 (In situ expression of RAE-1 message by intestinal epithelial goblet cells)

  Park Eun Jeong; Takahashi Ichiro; Fukuyama Satoshi; Kiyono Hiroshi

  日本免疫学会総会・学術集会記録, Nov. 2003

  
• MICAトランスジェニックマウスにおけるデキストラン硫酸ナトリウム誘発性腸炎の腸管粘膜免疫応答の解析

  池田 淳子; 河原 和子; 谷 亮治; 岡本 哲治; 朴 恩正; 清野 宏; 高橋 一郎

  日本免疫学会総会・学術集会記録, Nov. 2003

  
• 抗原の性状と抗体産生におけるパイエル板の役割

  國澤純; 高橋一郎; 清野 宏; 真弓忠範

  臨床免疫, 2002

  
• マウス腸管上皮細胞上のNKG2Dリガンド分子の発現(Expression of NKG2D ligand molecules on murine intestinal epithelial cells)

  Park Eun Jeong; Takahashi Ichiro; Fukuyama Satoshi; Kiyono Hiroshi

  日本免疫学会総会・学術集会記録, Dec. 2001

  
• 上皮細胞に対するセンダイウイルスならびに膜融合リポソームのMHC class II分子発現増強メカニズムに関する検討

  有山 輝子; 國澤 純; 高橋 一郎; 形山 和史; 増田 幸史; 堤 康央; 中川 晋作; 清野 宏; 真弓 忠範

  Drug Delivery System, Jul. 2001

  
• 粘膜ワクチンの新しい展開

  國澤純; 高橋一郎; 真弓忠範; 清野宏

  医学のあゆみ, 2001

  
• Development of chronic enterocolitis in SCID mice reconstituted with memory, spleen-derived CD4(+) T cells

  M Kweon; Takahashi, I; M Jang; M Yamamoto; H Kiyono

  FASEB JOURNAL, Apr. 2000

  
• Novel hybrid delivery vehicle, fusogenic liposome induces MHC class II-mediated mucosal and systemic helper T cell responses

  J Kunisawa; Takahashi, I; A Okudaira; K Katayama; S Nakagawa; T Mayumi; H Kiyono

  FASEB JOURNAL, Apr. 2000

  
• 可溶性タンパク抗原経口免疫における消化管内環境の影響

  奥平章子; 国沢純; 高橋一郎; 形山和史; 堤康央; 中川晋作; 清野宏; 真弓忠範

  日本薬学会年会要旨集, Mar. 2000

  
• 細胞性免疫誘導能を指標にした膜融合リポソームの経鼻ワクチンキャリアーとしての有用性評価

  国沢純; 奥平章子; 中西剛; 堤康央; 形山和史; 中川晋作; 真弓忠範; 高橋一郎; 清野宏

  日本薬学会年会要旨集, Mar. 2000

  
• IL-10ノックアウトマウスの腸炎：炎症性腸疾患におけるIL-10の役割

  奥田佳子; 高橋一郎; 清野宏

  別冊医学の歩み（サイトカインと疾患）, 2000, Invited

  
• Destruction of gastrointestinal immune system : A model of Th2 cytokine producing ββ^+ T-cell driven intestinal inflammation

  TAKAHASHI Ichiro; IIJIMA Hideki; KISHI Daisuke; KIYONO Hiroshi

  感染・炎症・免疫, 1999, Lead author

  
• TCR-alpha 欠損による炎症性腸疾患

  飯島英樹; 高橋一郎; 清野宏

  Annual Review 免疫1999, 1998, Invited

  
• 粘膜免疫からみた生体防御機構としての消化管

  岸大輔; 高橋一郎; 根津理一郎; 清野宏

  外科と代謝・栄養, 1997, Invited

  
• 粘膜ワクチンの理論と開発

  高橋一郎; 國澤純; 真弓忠範; 清野宏

  医学のあゆみ, 1997, Lead author

  
• Development of generalized autoimmunity by CD4(+) T cells in TCR alpha-chain deficient mice

  Takahashi, I; H Kiyono; S Hamada

  FASEB JOURNAL, Apr. 1996

  
• Impaired mucosal IgA responses in TCR delta(-/-) mice.

  K Fujihashi; McGhee, JR; M Kweon; MD Cooper; S Tonegawa; Takahashi, I; T Hiroi; J Mestecky; H Kiyono

  FASEB JOURNAL, Apr. 1996

  
• Epitope maps of the Escherichia coli heat-labile toxin B subunit for development of a synthetic oral vaccine

  Takahashi, I; H Kiyono; RJ Jackson; K Fujihashi; HF Staats; S Hamada; JD Clements; KL Bost; McGhee, JR

  INFECTION AND IMMUNITY, Apr. 1996

  
• Ｔ細胞による粘膜免疫の調節と破綻

  高橋一郎; 川端重忠; 清野宏; 浜田茂幸

  化学療法の領域, 1996, Invited, Lead author

  
• INDUCTION AND REGULATION OF IMMUNE-RESPONSES TO BIOENGINEERED MUCOSAL VACCINES

  MCGHEE, JR; M MARINARO; RJ JACKSON; TAKAHASHI, I; T HIROI; S CHATFIELD; J VANCOTT; D PASCUAL; F VANGINKLE; K FUJIHASHI; M YAMAMOTO; J CLEMENTS; K BOST; H KIYONO

  JOURNAL OF CELLULAR BIOCHEMISTRY, Jan. 1995

  
• GAMMA-DELTA-T-CELLS SUSTAIN INFECTIOUS IMMUNITY TO PERIODONTAL BACTERIA IN MICE

  TAKAHASHI, I; NAKAGAWA, I; A DEGUCHI; S HAMADA

  JOURNAL OF DENTAL RESEARCH, 1995

  
• ORAL IMMUNIZATION WITH A PARTIAL PEPTIDE OF ESCHERICHIA-COLI HEAT-LABILE TOXIN INDUCES TH2 CELL-MEDIATED S-IGA RESPONSES

  TAKAHASHI, I; HF STAATS; RJ JACKSON; H KIYONO; S HAMADA; JD CLEMENTS; KL BOST; MCGHEE, JR

  FASEB JOURNAL, Mar. 1994

  
• MOLECULAR ANALYSIS OF PORPHYROMONAS-GINGIVALIS FIMBRILLIN GENES AND RECOMBINANT PROTEINS

  T FUJIWARA; S MORISHIMA; TAKAHASHI, I; S HAMADA

  JOURNAL OF DENTAL RESEARCH, 1994

  
• コレラ菌特異的粘膜免疫の誘導と制御

  高橋一郎; 中川一路; 清野宏

  Medical Immunology, 1994, Invited, Lead author

  
• 遺伝子工学を応用した粘膜ワクチン

  高橋一郎; 清野宏

  Medical Immunology, 1993, Invited, Lead author

  
• Epitope scanning−マルチピンテクノロジーを利用した抗原エピトープの解析

  高橋一郎; 古賀敏比古

  生体防御, 1992, Invited, Lead author

  
• Streptococcus mutans の菌体表層タンパク質抗原に由来する合成ペプチドは Streptococcus mutans の口腔への定着を抑制する

  高橋一郎; 古賀敏比古

  臨床免疫, 1992, Invited, Lead author

  
• う蝕ワクチンの可能性

  高橋一郎; 岡橋暢夫; 古賀敏比古

  臨床検査, 1991, Invited, Lead author

  
• う蝕原性Streptococcus mutans の菌体表層タンパク質抗原遺伝子のクローニング

  高橋一郎; 岡橋暢夫; 古賀敏比古

  日本歯科評論, 1989, Invited, Lead author

  

Books and Other Publications

• 口腔科学

  清野宏; 高橋一郎, Contributor, 口腔・粘膜免疫

  朝倉書店, 2019

  
• 免疫学コア講義 改訂第4版

  高橋一郎, Contributor, 粘膜免疫

  南山堂, 2017

  
• 分子予防環境医学

  高橋一郎、岡橋暢夫、清野宏, Contributor

  本の泉社, 2010

  
• 臨床粘膜免疫学

  高橋一郎, Contributor, 粘膜免疫の誘導組織

  株式会社シナジー, 2010

  
• 口腔内科学

  高橋一郎、清野宏, Contributor

  飛鳥出版室, Apr. 2008

  
• Mucosal T cells

  Takahashi, I; Kiyono, H., Contributor

  Karger, 1998

  
• The immunobiology of Helicobacter pylori

  Takahashi, I; McGhee, J.R; Hamada, S; Kiyono, H, Contributor, Oral immunization approaches for the prevention of gastrointestinal diseases.

  Lippincott-Raven, 1997

  

Industrial Property Rights

• 特許5821128, 特願2011-033867, 大腸粘膜組織の免疫制御組成物

  高橋一郎

  
• 特許3089287, う蝕ワクチンの製造法

  古賀敏比古;岡橋暢夫;高橋一郎

  

External funds: Kakenhi

• 微生物細胞内共生現象の分子機構の生体エネルギー論的展開

  Grant-in-Aid for Scientific Research (C)

  Basic Section 49070:Immunology-related

  Hiroshima University

  高橋 一郎

  From 01 Apr. 2024, To 31 Mar. 2027, Granted

  微生物・細胞内共生;組織常在マクロファージ;S. maltophilia;smlt2713;perforin-2

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K10272/
• Molecular basis of host-microbe symbiosis within tissue resident macrophages

  Grant-in-Aid for Scientific Research (C)

  Basic Section 57020:Oral pathobiological science-related

  Hiroshima University

  ichiro takahashi

  From 01 Apr. 2019, To 31 Mar. 2023, Project Closed

  host microbe symbiosis;mucosal immunology;tissue macrophage;interleukin-10;mitochondrial OCR;微生物・細胞内共生;S. maltophilia;smlt2713;perforin-2;immune metabolism;macrophage;IL-10;粘膜免疫;マクロファージ;自然炎症;微生物細胞内共生;ミトコンドリア;炎症制御;恒常性

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K10088/
• The development of the vaccine for periodontal disease with using HVJ-envelope

  Grant-in-Aid for Scientific Research (C)

  Hiroshima University

  Keiko TSURUDA

  From 01 Apr. 2004, To 31 Mar. 2007, Project Closed

  TFF3ペプチド;HVJ-エンベロープ;遺伝子導入;タンパク発現;マウス個体;タンパク質発現;マウス;蛋白発現;粘液;トレフォイルファクター;TFF3;クローニング, TFF peptides;HVJ-envelope;Gene transfection;Protein expression;mice

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16592089/
• A novel mucosal immunomodulator MICA for homeostasis of the mucosal immune system

  Grant-in-Aid for Scientific Research (C)

  HIROSHIMA UNIVERSITY

  Ichiro TAKAHASHI

  From 01 Apr. 2004, To 31 Mar. 2006, Project Closed

  粘膜免疫;炎症性腸疾患;腸上皮細胞間リンパ球;MICA;NKG2D;IL-15, mucosal immunity;MICA;intraepithelial lymphocytes;inflammatory bowel disease;IL-15;NKG2D

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16590406/
• 胸腺外分化T細胞の生理的リガンドの探索と感染防御における病因論的役割の解析

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Hiroshima University

  高橋 一郎

  From 01 Apr. 2002, To 31 Mar. 2003, Project Closed

  粘膜免疫;胸腺外分化Tリンパ球;サイトカイン;免疫制御;微生物感染;ワクチン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14021059/
• 胸腺外分化T細胞の生理的リガンドの探索と感染防御における病因論的役割の解析

  Grant-in-Aid for Scientific Research on Priority Areas (C)

  Biological Sciences

  Osaka University

  高橋 一郎

  From 01 Apr. 2001, To 31 Mar. 2002, Project Closed

  粘膜免疫;胸腺外分化;粘膜系T細胞;NKG2D;NKG2D ligand;感染免疫

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13226065/
• Molecular biology of extrathymic T cells for the development of mucosal inflammation

  Grant-in-Aid for Scientific Research (C)

  OSAKA UNIVERSITY

  Ichiro TAKAHASHI

  From 01 Apr. 2000, To 31 Mar. 2002, Project Closed

  粘膜免疫;胸腺外分化;粘膜系T細胞;炎症;免疫病;T細胞;炎症性腸疾患, MUCOSAL IMMUNOLOGY;EXTRATHYMIC T CELLS;INFLAMMATION;CROHN'S DISEASE;PUBLIC CDR3 MOTIF

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12670303/
• A study of the environmental factors for the development of inflammatory bowel disease

  Grant-in-Aid for Scientific Research (C)

  Osaka University

  Yoshifumi INOUE

  From 01 Apr. 1998, To 31 Mar. 2000, Project Closed

  炎症性腸疾患;TCRα鎖欠損マウス;粘膜免疫;食餌抗原;成分栄養;腸内細菌叢;Bacteroides vulgatus, inflammatory bowel disease;TCR α-;- mice;mucosal immune system;elemental diet;enteric flora;Bacteroides vulgatus

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10671113/
• Molecular biology of oligoclonal ββィイD1+ィエD1 T cells in murine inflammatory bowel disease

  Grant-in-Aid for Scientific Research (C)

  Osaka University

  Ichiro TAKAHASHI

  From 01 Apr. 1998, To 31 Mar. 2000, Project Closed

  粘膜免疫;炎症性腸疾患;ββT細胞;Th2型サイトカイン;Bacteroides属;Th2系サイトカイン;PCR-SSCP;TCR beta;beta;クロナリティ-;腸内細菌, ββ T cells;Th2 cytokine;IBD;mucosal T cells;clonality;gut-flora

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10670302/
• Characterization of Novel Mucosal Modulator for IgA

  Grant-in-Aid for Scientific Research (B).

  Osaka University

  Hiroshi KIYONO

  From 01 Apr. 1998, To 31 Mar. 2000, Project Closed

  粘膜免疫システム;粘膜ワクチン;粘膜アジュバント;粘膜免疫調節因子;無毒化変異型CT;経口ワクチン;経鼻ワクチン;IgA;粘膜アジュバンド;粘膜免疫, Mucosal vaccine;Secretory IgA;Mucosal immune system;Mucosal adjuvant;mutant CT;IL-12;Mucosal cytokine

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10044284/
• Characterization of mucosal intranet formed by γδ/αβ T cells and epithelial cells

  Grant-in-Aid for Scientific Research (A).

  Osaka University

  Hiroshi KIYONO

  From 01 Apr. 1997, To 31 Mar. 2001, Project Closed

  粘膜免疫;パイエル板;CMIS;B-1細胞;IL-5;IL-15;CMIS独立型;粘膜細胞イントラネット;粘膜細胞間インターネット;粘膜細胞間イントラネット;粘膜免疫機構;粘膜誘導型寛容;経口免疫寛容;粘膜系γδT細胞;TCRδ遺伝子欠損マウス;IL-10;上皮細胞間リンパ球;IgA;コレラ毒素;IL-7;IL-7R;γδT細胞;上皮細胞, Mucosal immune system;Mucosal intranet;Epithelial cell;Mucosal T cells;IgA;Peyer's patch;B-1;B-2 cells

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09307006/
• T細胞受容体欠損マウスを用いた経口免疫寛容の分子メカニズムの解明

  Grant-in-Aid for Encouragement of Young Scientists (A)

  Osaka University

  高橋 一郎

  From 01 Apr. 1996, To 31 Mar. 1997, Project Closed

  粘膜免疫;トレランス;アレルギー;ノックアウトマウス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08771572/
• Mucosal Vaccines : Vectors and Adjuvants for Novel Th1 and Th2 cells

  Grant-in-Aid for international Scientific Research

  Osaka University

  Hiroshi KIYONO

  From 01 Apr. 1996, To 31 Mar. 1998, Project Closed

  粘膜ワクチン;粘膜免疫;IgA;Th1型細胞;Th2型細胞;IL-12;粘膜免疫調節因子;粘膜アジュバント;無毒化リコンビナントサルモネラ菌;経口免疫;IFN-γ遺伝子欠損マウス;Th1型;Th2型応答;レベル2 Th2型;経口ワクチン, Mucosal Immune System;Mucosal Vaccine;Mucosal Intranet;IgA;Mucosal Modulator;Mucosal Adjuvant;Mucosal Th1;Mucosal Th2

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08044285/
• 細胞感染に起因する粘膜免疫の細胞生物学的研究

  Grant-in-Aid for Encouragement of Young Scientists (A)

  Osaka University

  高橋 一郎

  From 01 Apr. 1995, To 31 Mar. 1996, Project Closed

  感染免疫;粘膜免疫;細菌毒素;T細胞;サイトカイン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07771604/
• 粘膜免疫誘導エピトープのマッピング

  Grant-in-Aid for Encouragement of Young Scientists (A)

  Osaka University

  高橋 一郎

  From 01 Apr. 1994, To 31 Mar. 1995, Project Closed

  免疫;経口ワクチン;感染免疫

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06771583/
• Development of mutacin MT6223 from Streptococcus sobrinus as an anti-caries agent

  Grant-in-Aid for Scientific Research (A)

  Osaka University

  Shigeyuki HAMADA

  From 01 Apr. 1994, To 31 Mar. 1997, Project Closed

  ミュータシン;バクテリオシン;う触;Streptococcus mutans;Streptococcus sobrinus;う蝕, mutacin;Streptococcus mutans;dental caries;Streptococcus sobrinas;bacteriocin

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06557099/
• Bacterial endotoxic substances from periodontopathic bacteria and their effects on host cells

  Grant-in-Aid for General Scientific Research (B)

  Osaka University

  Shigeyuki HAMADA

  From 01 Apr. 1993, To 31 Mar. 1996, Project Closed

  細菌内毒素;歯周病原性細菌;宿主反応;マウスBリンパ球;チロシンリン酸化反応;Porphyromonas gingivalis;fimbriae;Porphyromomas gingivalis;歯周病原菌;内毒素;LPS;表面抗原;マウス;線維芽細胞;C3H;HeJマウス;シグナル伝達;歯周炎, Endotoxin (lipopolysaccharide);Periodontopathic bacteria;Host responses;murine B lymphocytes;Tyrosine Protein Phosphorylation;Porphyromonas gingivalis;fimbriae

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05454192/
• Development of Anti-Dental Caries Vaccine Using Recombinant Lactic Streptococci

  Grant-in-Aid for Developmental Scientific Research (B).

  National Institute of Health

  Toshihiko KOGA

  From 01 Apr. 1988, To 31 Mar. 1991, Project Closed

  齲蝕;Streptococcus mutans;Streptococcus sobrinus;乳酸菌;ワクチン;DNA組換え;う蝕, Dental Caries;Streptococcus mutans;Streptococcus sobrinus;Lactic Streptococci;Vaccine

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-63870086/

Academic, Social Contribution

Committee Memberships

• From 2017, To 2022

  評議員, 日本免疫学会