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Ota, Takeshi

Graduate School of Agriculture, Division of Applied Biosciences Professor

Ota, Takeshi
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    Last Updated :2022/09/30

    Basic Information

    Faculty

    • 農学部

    Professional Memberships

    • 関西実験動物研究会
    • Kansai Animal Science Society
    • Japan Diabetic Nephropathy Study
    • Japan Society of Experimental Diabetes and Obesity
    • THE JAPAN DIABETES SOCIETY
    • HOKUSHINETSU JAPANESE SOCIETY OF ANIMAL SCIENCE
    • JAPANESE ASSOCIATION FOR LABORATORY ANIMAL SCIENCE
    • THE JAPANESE SOCIETY OF VETERINARY SCIENCE
    • JAPANESE SOCIETY OF ANIMAL SCIENCE

    Academic Degree

    • 農学修士(京都大学)
    • 博士(農学)(京都大学)

    Academic Resume (Graduate Schools)

    • 京都大学, 大学院農学研究科修士課程畜産学専攻, 修了

    Academic Resume (Undergraduate School/Majors)

    • 京都大学, 農学部畜産学科, 卒業

    High School

    • High School

      千葉県立千葉高等学校

    Research History

    • From Apr. 2019, To Present
      京都大学大学院, 農学研究科
    • From Apr. 1989, To Mar. 2019
      日本たばこ産業㈱, 医薬総合研究所

    ID,URL

    researchmap URL

    list
      Last Updated :2022/09/30

      Research

      Research Topics, Overview of the research

      • Research Topics

        Pathophysiological investigation in animal model of metabolic disease and research on the optimization
      • Overview of the research

        We investigate pathophysiological features in target organs, such as liver, kidney, pancreas, and intestine, in diabetic animal models using physiological, pharmacological, and anotomical/histological methods. Furthermore, we examine the pathophysiological changes in various feeding and/or water-supply conditions.

      Research Areas

      • Life sciences, Zoological sciences

      Papers

      • Identification of PPARGC1A-reguletaed oxidative phosphorylation pathway showing heat stress-responsive activation associated with low heat stress tolerance for growth rate in skeletal muscle tissue of finishing pig
        Masumoto R; Sukegawa S; Ohta T; Yamada T; Yamazaki M; Inoue H; Fujii T; Okamoto S; Iwaisaki H
        The Journal of Animal Genetics, 2022, Peer-reviewed
      • Differences in the effects of pentobarbital anesthetic and combination of medetomidine hydrochloride, midazolam, and butorphanol tartrate anesthetic on electroretinogram in Spontaneously Diabetic Torii fatty rats
        Hasegawa T; Takagi R; Tanaka Y; Ohta T; Shinohara M; Kageyama Y; Sasase T; Muramatsu S; Kaburaki T; Kakehashi A
        Biomedicine Hub, 2022, Peer-reviewed
      • Establishment of a new nonalcoholic steatohepatitis model; Ovariectomy exacerbates nonalcoholic steatohepatitis-like pathology in diabetic rats
        Saigo Y; Sasase T; Uno K; Shinozaki Y; Maekawa T; Sano R; Toriniwa Y; Miyajima K; Ohta T
        J. Pharmacol. Toxicol. Methods, 2022, Peer-reviewed, Last author
      • Morphological analysis of the retina in salt-loaded KK-Ay mice, obese and type 2 diabetic model
        Maekawa T; Sasase T; Shinohara M; Ohta T
        JSMARTech, 2022, Peer-reviewed, Last author, Corresponding author
      • Pathophysiological analysis of uninephrectomized db/db mice as a model of severe diabetic kidney disease
        Maekawa M; Maekawa T; Sasase T; Takagi K; Takeuchi S; Kitamoto M; Nakagawa T; Toyoda K; Konishi N; Ohta T; Yamada T
        Physiol. Res., 2022, Peer-reviewed
      • Transient Receptor Potential Vanilloid (TRPV) channels: Basal Properties and physiological potential
        Sasase T; Fatchiyah F; Ohta T
        Gen. Physiol. Biophy., 2022, Peer-reviewed, Last author
      • Pathophysiological features in the brains of female Spontaneously Diabetic Torii (SDT) fatty rats
        Maekawa T; Sugimoto M; Kume S; Ohta T
        J. Vet. Med. Sci., 2022, Peer-reviewed, Last author
      • Salt loading with unilateral nephrectomy accelerate decline in glomerular filtration rate in the hypertensive, obese, type 2 diabetic SDT fatty rat model of diabetic kidney disease
        Shinozaki Y; Katayama Y; Yamaguchi F; Suzuki T; Watanabe K; Uno K; Tsutsui T; Sugimoto M; Shinohara M; Miyajima K; Ohta T
        Clin. Exp. Pharmacol. Physiol., 2022, Peer-reviewed, Last author
      • Immune disorders and sex differences in Spontaneously Diabetic Torii rats, type 2 diabetic model
        Kobayashi K; Sasase T; Maekawa T; Shinozaki Y; Sano R; Yamada T; Ohta T
        Physiol. Res., 2022, Peer-reviewed, Last author
      • Effects of excessive sodium chloride loading in the spontaneously diabetic torii (SDT) fatty rats, a preclinical model of type 2 diabetes mellitus
        Teoh SH; Miyajima K; Shinozaki Y; Shinohara M; Ohata K; Briand F; Morimoto R; Nakamura Y; Uno K; Kemuriyama N; Nakae D; Ohta T; Maekawa T
        J. Toxicol. Sci., 2021, Peer-reviewed
      • Establishment of method for habitability evaluation in rats
        Yamamoto S; Inaba N; Maeno T; Hirao T; Yamanaka S; Shinozaki Y; Ohta T
        J. Exp. Anim. Technol., 2021, Peer-reviewed, Last author
      • Ocular changes -cataract and retinal lesion- in Spontaneously Diabetic Torii (SDT) fatty rats, an obese type 2 diabetic model
        Maekawa T; Nakamura S; Miyajima K; Uno K; Yamaguchi A; Mandai K; Gotoh T; Shinohara M; Shinozaki Y; Sasase T; Fatchiyah F; Ohta T
        JSMARTech, 2021, Peer-reviewed, Last author
      • Bilateral midbrain transection induced hyperphagia accelerates the development of diabetes in Spontaneously Diabetic Torii (SDT) rats
        Sasase T; Ito M; Ishii Y; Ohta T
        JSMARTech, 2021, Peer-reviewed, Last author
      • The amelioration of T2DM rat femoral bone achieved by anti-osteoporosis of caprine CSN1S2 protein through bone morphogenetic protein signaling pathway
        Fatchiyah F; Setiawan B; Sasase T; Ohta T
        Acta Biochim. Pol., 2021, Peer-reviewed, Last author
      • GPR52 accelerates fatty acid biosynthesis in a ligand-dependent manner in hepatocytes and in response to excessive fat intake in mice
        Wada M; Yukawa K; Ogasawara H; Suzawa K; Maekawa T; Yamamoto Y; Ohta T; Lee E; Miki T
        iScience, 2021, Peer-reviewed
      • JTP-117968, a novel selective glucocorticoid receptor modulator, exhibits significant anti-inflammatory effects while maintaining bone mineral density in mice
        Kurimoto T; Tamai I; Nakagawa T; Miyai A; Yamamoto Y; Kosugi Y; Deai K; Hata T; Ohta T; Matsushita M; Yamada T
        Eur. J. Pharmacol., 2021, Peer-reviewed
      • Glomerular hyperfiltration with hyperglycemia in the Spontaneously Diabetic Torii (SDT) fatty rat, an obese type 2 diabetic model
        Sano R; Ishii Y; Yamanaka M; Yasui Y; Kemmochi Y; Kuroki F; Sugimoto M; Fukuda S; Sasase T; Miyajima K; Nakae D; Ohta T
        Physiol. Res., 2021, Peer-reviewed, Last author
      • JTP-109192, a novel G protein-coupled receptor 119 agonist, prevents atherosclerosis by improving hypercholesterolemia in congenic spontaneously hyperlipidaemic mice
        Tadaki H; Ogawa N; Yamanaka M; Motohashi Y; Sasase T; Kawai T; Toriniwa Y; Fukuda S; Ogawa N; Harada K; Ohta T; Yamada T
        Clin. Exp. Pharmacol. Physiol., 2021, Peer-reviewed
      • The sphingosine-1-phosphate receptor modulator, FTY720, prevents the incidence of diabetes in Spontaneously Diabetic Torii rats
        Kobayashi K; Sasase T; Ishii Y; Katsuda Y; Miyajima K; Yamada T; Ohta T
        Clin. Exp. Pharmacol. Physiol., 2021, Peer-reviewed, Last author
      • Embryonic MTHFR contributes to blastocyst development
        Ishitani H; Ikeda S; Egashira K; Sugimoto M; Kume S; Minami N; Ohta T
        J. Assist. Reprod. Genet., 2020, Peer-reviewed, Last author
      • The Caprine casein-alpha-S2 protein modulates the molecular mechanism of insulin signal transduction in Type2 diabetes rat
        Fatchiyah F; Rohmah RN; Tripsila LF; Ohta T; Meidinna HN
        Acta Biochim. Pol., 2020, Peer-reviewed
      • Sodium-glucose Co-transporters: Functional Properties and Pharmaceutical Potential
        Sano Y; Shinozaki Y; Ohta T
        J. Diabetes Investig., 2020, Peer-reviewed, Invited, Last author, Corresponding author
      • Hyperglycemia contributes to a devlopment of leydig cell hyperplasia in male Spontaneously Diabetic Torii rats
        Nakane Y, Kemmochi Y, Ogawa N, Sasase T, Ohta T, Higami Y, Fukai F
        J. Toxicol. Pathol., 2020, Peer-reviewed
      • Analysis of haemodynamics and angiogenic response to ischemia in the obese type 2 diabetic model Spontaneously Diabetic Torii Leprfa (SDT fatty) rats
        Murai Y; Sasase T; Tadaki H; Heitaku S; Imagawa N; Yamada T; Ohta T
        Clin. Exp. Pharmacol. Physiol., 2020, Peer-reviewed
      • Conventional and novel impacts of ferric citrate on iron deficiency anemia and phosphorus metabolism in rats
        Iida A; Matsushita M; Ohta T; Yamada T
        J. Vet. Med. Sci., 2020, Peer-reviewed
      • Molecular assessment of genetic diversity in the Japanese population of the Japanese Crested Ibis.
        Yamada T; Nagata H; Ikenori D; Taniguchi Y; Ohta T; Sugiyama T; Homma K; Kaneko Y; Iwaisaki H
        Ornithol. Sci., 2019, Peer-reviewed
      • A novel TNF-α converting enzyme (TACE) selective inhibitor JTP-96193 prevents insulin resistance in KK-Ay type 2 diabetic mice and diabetic peripheral neuropathy in type 1 diabetic mice.
        Maekawa M; Tadaki H; Tomimoto D; Okuma C; Sano R; Ishii Y; Katsuda Y; Yoshiuchi H; Kakefuda R; Ohta T; Sasase T
        Biol. Pharm. Bull., 2019, Peer-reviewed
      • Level of mRNA insulin gene and blood gluocse STZ-induced diabetic rats are improved by glucomannan of Amorphophallus muelleri Blume from East Java forest Indonesia
        Fatchiyah F; Nurmasari DA; Masruro N; Rohmah RN; Triprisila LF; Mulyati MM; Yamada T; Ohta T
        J. Trop. Life Sci., 2019, Peer-reviewed
      • Chronic treatment of JTP-109192, a novel G-protein coupled receptor 119 agonist, improves metabolic abnormalities in Zucker Fatty rats
        Tadaki H; Sasase T; Fukuda S; Toriniwa Y; Harad K; Ohta T; Yamada T
        Clin. Exp. Pharmacol. Physiol., 2019, Peer-reviewed
      • Pathological features of diabetic retinopathy in Spontaneously Diabetic Torii fatty rats.
        Tanaka Y; Takagi R; Ohta T; Sasase T; Kobayashi M; Toyoda F; Shimmura-Tomita M; Kinoshita N; Takano H; Kakehashi A
        J. Diabetes Res., 2019, Peer-reviewed
      • Pathological analysis of the intestinal tract in SDT fatty rats, an obese type 2 diabetic rat
        Maekawa M; Tadaki H; Katsuda Y; Shinohara M; Miyajima K; Yamada T; Ohta T
        Hokushinetsu Journal of Animal Science, 2019, Peer-reviewed
      • Pathophysiological changes in livers of Zucker fatty rats induced by a feeding cholesterol-enriched diet
        Saito T; Toriniwa Y; Ishii Y; Miyajima K; Maekawa T; Uemura A; Shinohara M; Yamada T; Ohta T
        Hokushinetsu Journal of Animal Science, 2019, Peer-reviewed
      • Pathophysiological changes in livers of Spontaneously Diabetic Torii (SDT) fatty rats, an obese type 2 diabetic model, induced by feeding a Quick Fat diet
        Toriniwa Y; Saito T; Taniai E; Ishii Y; Miyajima K; Maekawa T; Shinohara M; Yamada T; Ohta T
        Hokushinetsu Journal of Animal Science, 2019, Peer-reviewed
      • Investigation of changes in the blood coagulation system in type 2 diabetic rats
        Yusuke KEMMOCHI; Yasutaka MURAI; Satomi TAKEUCHI; Hideaki YAMASHIRO; Masami SHINOHARA; Takahisa YAMADA; Takeshi OHTA
        Hokushinetsu Journal of Animal Science, Mar. 2018, Peer-reviewed
      • Quantitative changes in visceral and subcutaneous fats in food restricted female and male Spontaneously Diabetic Torii (SDT) fatty rats, an obese type 2 diabetic model
        Miyajima K; Murai Y; Ishii Y; Sasase T; Shinohara M; Yamashiro H; Yamada T; Ohta T
        Hokushinetsu Journal of Animal Science, Mar. 2018, Peer-reviewed
      • Pharmacological effects of angiotensin II receptor blocker (ARB) losartan in male Spontaneously Diabetic Torii (SDT) fatty rats, an obese type 2 diabetic model
        Miyajima Y; Kemmochi Y; Motohashi Y; Toriniwa Y; Murai Y; Shinohara M; Yamashiro H; Yamada T; Ohta T
        Hokushinetsu Journal of Animal Science, Mar. 2018, Peer-reviewed
      • Spontaneously Diabetic Torii (SDT) fatty rat, a novel animal model of type 2 diabetes mellitus, shows blunted circadian rhythms and melatonin secretion.
        Sakimura K; Maekawa T; Kume S; Ohta T
        Int. J. Endocrinol., 2018, Peer-reviewed
      • Quick-Fat diet inhibits the development of diabetes in Spontaneously Diabetic Torii (SDT) rats.
        Ohta T; Yamada T; Kamiya T; Gotoh T; Tsubaki M; Shinohara M
        Thai J. Pharmaceu. Sci., 2018, Peer-reviewed
      • Pathophysiological abnormalities in the brains of Spontaneously Diabetic Torii-Leprfa (SDT fatty) rats, a novel type 2 diabetic model.
        Maekawa T; Ohta T; Kume S
        J. Vet. Med. Sci., 2018, Peer-reviewed
      • Hepatic lesions induced by feeding Western diets to Zucker fatty rats, an insulin resistant model.
        Saito T; Toriniwa Y; Ishii Y; Uemura A; Miyajima K; Uno K; Shirai Y; Nakae D; Ohta T
        J. Toxcol. Pathol., 2018, Peer-reviewed
      • Investigation of pharmacological responses to anti-diabetic drugs in female Spontaneously Diabetic Torii (SDT) fatty rats, a new nonalcoholic steatohepatitis (NASH) model
        Yasufumi Toriniwa; Tomoyuki Saito; Katsuhiro Miyajima; Yukihito Ishii; Kinuko Uno; Tatsuya Maekawa; Tohru Matsui; Shinichi Kume; Takahisa Yamada; Takeshi Ohta
        Journal of Veterinary Medical Science, 2018, Peer-reviewed
      • Depression-related behavioral and neuroendocrine changes in the Spontaneously Diabetic Torii (SDT) fatty rat, an animal model of Type 2 Diabetes Mellitus.
        Sakimura K; Maekawa T; Sasagawa K; Ishii Y; Kume S; Ohta T
        Clin. Exp. Pharmacol. Physiol., 2018, Peer-reviewed
      • Jte-852, a novel spleen tyrosine kinase inhibitor, blocks antigen-induced allergic reactions in rats
        Toshinobu Kato; Takeshi Ohta; Hidenori Iwasaki; Hatsue Kobayashi; Akira Matsuo; Takahiro Hata; Mutsuyoshi Matsushita
        Journal of Veterinary Medical Science, 2018, Peer-reviewed
      • Effects on glycemic control in impaired wound healing in Spontaneously Diabetic Torii (SDT) fatty rats.
        Miyajima K; Teoh SH; Yamashiro H; Shinohara M; Fatchiyah F; Ohta T; Yamada T
        Med. Arch., 2018, Peer-reviewed
      • Pathophysiological analyses of skeletal muscle in obese type 2 diabetes SDT fatty rats
        Yusuke Kemmochi; Takeshi Ohta; Yu Motohashi; Akihiro Kaneshige; Sohei Katsumi; Kochi Kakimoto; Yuzo Yasui; Akiko Anagawa-Nakamura; Kaoru Toyoda; Eriko Taniai-Riya; Akemi Takahashi; Toshiyuki Shoda; Takahisa Yamada
        Journal of Toxicologic Pathology, 2018, Peer-reviewed
      • Pathophysiological characteristics of non-alcoholic steatohepatitis-like changes in cholesterol-loaded type 2 diabetic rats.
        Toriniwa Y; Muramatsu M; Ishii Y; Riya E; Miyajima K; Oshida S; Kitatani K; Takekoshi S; Matsui T; Kume S; Yamada T; Ohta T
        Physiol. Res., 2018, Peer-reviewed
      • Diabetic macular edema-like ocular lesions in male spontaneously diabetic Torii fatty rats.
        Motohashi Y; Kemmochi Y; Maekawa T; Tadaki H; Sasase T; Tanaka Y; Kakehashi A; Yamada T; Ohta T
        Physiol. Res., 2018, Peer-reviewed
      • JTE-852, a novel spleen tyrosine kinase inhibitor, blocks immunoglobulin G-mediated cellular responses and autoimmune reactions in vivo
        Toshinobu Kato; Takeshi Ohta; Hidenori Iwasaki; Hatsue Kobayashi; Akira Matsuo; Takahiro Hata; Mutsuyoshi Matsushita
        LIFE SCIENCES, Dec. 2017, Peer-reviewed
      • Pathophysiological profiles of SDT fatty rats, a potential new diabetic peripheral neuropathy model
        Tatsuya Maekawa; Hironobu Tadaki; Tomohiko Sasase; Yu Motohashi; Katsuhiro Miyajima; Takeshi Ohta; Shinichi Kume
        JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, Nov. 2017, Peer-reviewed
      • Pathophysiological effects of food restriction on the pancreas in female Spontaneously Diabetic Torii (SDT) fatty rats, an obese type 2 diabetic model
        Miyajima K; Ohta T; Murai Y; Ishii Y; Shinohara M; Yamada T
        Hokushinetsu Journal of Animal Science, 2017, Peer-reviewed
      • Investigation of the effects of pioglitazone on nonalcoholic steatohepatitis (NASH) –like lesions in female Spontaneously Diabetic Torii (SDT) fatty rats
        Motohashi Y; Ohta T; Taniai E; Toriniwa Y; Kemmochi Y; Ishii Y; Shinohara M; Yamada T; Ohta T
        Hokushinetsu Journal of Animal Science, 2017, Peer-reviewed
      • Assessment of pharmacological responses to an anti-diabetic drug in a new obese type 2 diabetic rat model.
        Murai Y; Ohta T; Tadaki H; Miyajima K; Shinohara M; Fatchiyah F; Yamada T
        Med. Arch., 2017, Peer-reviewed
      • Investigation of pharmacological responses to an anti-diabetic drug pioglitazone in female Spontaneously Diabetic Torii (SDT) fatty rats, a new obese type 2 diabetic rat.
        Murai Y; Miyajima K; Shinohara M; Yamada T; Ohta T
        Scientific J. Diabetol., 2017, Peer-reviewed
      • Safe dosage of caprine CSN1S2 protein from fresh local goat milk for rats evaluated by acute and sub-chronic toxicity testing
        Fatchiyah; Bambang Setiawan; Nia Kania; Takeshi Ohta; Vita Agustina; Suharjono
        Journal of Mathematical and Fundamental Sciences, 2017, Peer-reviewed
      • Pathophysiological Analysis of the Progression of Hepatic Lesions in STAM Mice
        T. Saito; M. Muramatsu; Y. Ishii; Y. Saigo; T. Konuma; Y. Toriniwa; K. Miyajima; T. Ohta
        PHYSIOLOGICAL RESEARCH, 2017, Peer-reviewed
      • Hepatocellular adenoma with severe fatty change in a male spontaneously diabetic Torii rat
        Eriko Taniai-Riya; Katsuhiro Miyajima; Kochi Kakimoto; Takeshi Ohta; Yuzo Yasui; Yusuke Kemmochi; Akiko Anagawa-Nakamura; Kaoru Toyoda; Akemi Takahashi; Toshiyuki Shoda
        Journal of Toxicologic Pathology, 2017, Peer-reviewed
      • Maternal high-fat diet promotes onset of diabetes in rat offspring
        Takeshi Ohta; Yasufumi Toriniwa; Naruhiko Ryumon; Nobuhiro Inaba; Tadaaki Hirao; Saori Yamanaka; Takayuki Maeno; Wakako Sakakibara; Morio Sumikawa; Kaoru Chiba; Akiko Nakamura; Katsuhiro Miyajima; Fatchiyah Fatchiyah; Takahisa Yamada
        ANIMAL SCIENCE JOURNAL, Jan. 2017, Peer-reviewed
      • Identification of genes showing differential expression profile associated with growth rate in skeletal muscle tissue of Landrace weanling pig
        Yuuta Komatsu; Shin Sukegawa; Mai Yamashita; Naoki Katsuda; Bin Tong; Takeshi Ohta; Hiroyuki Kose; Takahisa Yamada
        JOURNAL OF GENETICS, Jun. 2016, Peer-reviewed
      • Intrajejunal infusion of 2-monoacylglycerol reduced food intake without inducing diarrhea in rats
        Chihiro Okuma; Takeshi Ohta; Makoto Ito; Hironobu Tadaki; Tomohiro Oda; Shinichi Kume; Jun Nishiu; Makoto Kakutani
        JOURNAL OF PHARMACOLOGICAL SCIENCES, Feb. 2016, Peer-reviewed
      • 新規肥満2型糖尿病モデル雄性SDT fattyラットの維持・繁殖生産技術の向上と課題について.
        稲葉信博; 龍門徳彦; 平尾直啓; 山中沙織; 前野孝之; 安里千秋; 高橋明之; 千葉薫; 笹瀬智彦; 山田宜永; 太田毅
        Hokushinetsu Journal of Animal Science, 2016, Peer-reviewed
      • Pathophysiological changes on spermatogenesis in non-obese diabetic model, male Spontaneously Diabetic Torii (SDT) rats
        Nobuhiro INABA; Yusuke KEMMOCHI; Naruhiko RYUMON; Tadaaki HIRAO; Saori YAMANAKA; Kaoru CHIBA; Takeshi OHTA; Takahisa YAMADA; Katsuhiro MIYAJIMA
        Hokushinetsu Journal of Animal Science, 2016, Peer-reviewed
      • Pathophysiological changes with aging in a novel obese diabetic rat.
        Ohta T; Shinohara M; Gotoh T; Yamada T; Miyajima K
        M. J. Nutr., 2016, Peer-reviewed
      • JTT-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, ameliorates lipid metabolism and attenuates atherosclerosis in hyperlipidemic animal models
        Yasuko Mera; Takashi Kawai; Naoto Ogawa; Naoya Odani; Tomohiko Sasase; Katsuhiro Miyajima; Takeshi Ohta; Makoto Kakutani
        JOURNAL OF PHARMACOLOGICAL SCIENCES, Nov. 2015, Peer-reviewed
      • Association of the expression levels in the longissimus muscle and a SNP in the CDC10 gene with marbling in Japanese Black beef cattle
        B. Tong; G. Q. Gao; Y. Muramatsu; T. Ohta; H. Kose; G. P. Li; F. Fatchiyah; T. Yamada
        MEAT SCIENCE, Oct. 2015, Peer-reviewed
      • Bone morphological analyses in Spontaneously Diabetic Toni (SDT) fatty rats
        Takeshi Ohta; Shuichi Kimura; Masaya Hirata; Takahisa Yamada; Toshie Sugiyama
        JOURNAL OF VETERINARY MEDICAL SCIENCE, Oct. 2015, Peer-reviewed
      • JTT-553, a novel Acyl CoA:diacylglycerol acyltransferase (DGAT) 1 inhibitor, improves glucose metabolism in diet-induced obesity and genetic T2DM mice
        Daisuke Tomimoto; Chihiro Okuma; Yukihito Ishii; Akio Kobayashi; Takeshi Ohta; Makoto Kakutani; Tsuneo Imanaka; Nobuya Ogawa
        JOURNAL OF PHARMACOLOGICAL SCIENCES, Sep. 2015, Peer-reviewed, Invited
      • Female spontaneously diabetic Torii fatty rats develop nonalcoholic steatohepatitis-like hepatic lesions
        Yukihito Ishii; Yu Motohashi; Makoto Muramatsu; Yoshiaki Katsuda; Katsuhiro Miyajima; Tomohiko Sasase; Takahisa Yamada; Tohru Matsui; Shinichi Kume; Takeshi Ohta
        WORLD JOURNAL OF GASTROENTEROLOGY, Aug. 2015, Peer-reviewed
      • JTP-103237, a monoacylglycerol acyltransferase inhibitor, prevents fatty liver and suppresses both triglyceride synthesis and de novo lipogenesis
        Chihiro Okuma; Takeshi Ohta; Hironobu Tadaki; Tatsuya Ishigure; Shohei Sakata; Hideyuki Taniuchi; Ryuhei Sano; Hiromi Hamada; Shinichi Kume; Jun Nishiu; Makoto Kakutani
        JOURNAL OF PHARMACOLOGICAL SCIENCES, Jul. 2015, Peer-reviewed
      • JTP-103237, a novel monoacylglycerol acyltransferase inhibitor, modulates fat absorption and prevents diet-induced obesity
        Chihiro Okuma; Takeshi Ohta; Hironobu Tadaki; Hiromi Hamada; Tomohiro Oda; Hideyuki Taniuchi; Kenji Yamanaka; Yukihito Ishii; Yasuhiro Ohe; Shinji Yata; Jun Nishiu; Yusuke Aratsu; Shinichi Oshida; Shinichi Kume; Makoto Kakutani
        EUROPEAN JOURNAL OF PHARMACOLOGY, Jul. 2015, Peer-reviewed
      • Association of the expression level of the MYBPC1 gene in skeletal muscle with marbling trait in Japanese Black beef cattle
        Bin Tong; Youji Muramatsu; Takeshi Ohta; Hiroyuki Kose; Hideaki Yamashiro; Toshie Sugiyama; Takashisa Yamada
        Annals of Animal Science, Apr. 2015, Peer-reviewed
      • ASSOCIATION OF THE EXPRESSION LEVEL OF THE MYBPC1 GENE IN SKELETAL MUSCLE WITH MARBLING TRAIT IN JAPANESE BLACK BEEF CATTLE
        Bin Tong; Youji Muramatsu; Takeshi Ohta; Hiroyuki Kose; Hideaki Yamashiro; Toshie Sugiyama; Takashisa Yamada
        Annals of Animal Science, Apr. 2015, Peer-reviewed
      • Contribution of hyperglycemia on diabetic complications in obese type 2 diabetic SDT fatty rats: effects of SGLT inhibitor phlorizin
        Yoshiaki Katsuda; Tomohiko Sasase; Hironobu Tadaki; Yasuko Mera; Yu Motohashi; Yusuke Kemmochi; Kaoru Toyoda; Kochi Kakimoto; Shinichi Kume; Takeshi Ohta
        EXPERIMENTAL ANIMALS, Apr. 2015, Peer-reviewed
      • Association of the expression levels in the skeletal muscle and a SNP in the CDC10 gene with growth-related traits in Japanese Black beef cattle
        B. Tong; G. P. Li; S. Sasaki; Y. Muramatsu; T. Ohta; H. Kose; T. Yamada
        ANIMAL GENETICS, Apr. 2015, Peer-reviewed
      • Association of expression levels in skeletal muscle and a SNP in the MYBPC1 gene with growth-related trait in Japanese Black beef cattle
        Bin Tong; Yan Ping Xing; Youji Muramatsu; Takeshi Ohta; Hiroyuki Kose; Huan Min Zhou; Takahisa Yamada
        JOURNAL OF GENETICS, Mar. 2015, Peer-reviewed
      • Pharmacological Characterization of [trans-5 '-(4-Amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-y1)-2 ',3 '-dihydrospiro(cyclohexane-1,1 '-inden)-4-yl]acetic Acid Monobenzenesulfonate (JTT-553), a Novel Acyl CoA:Diacylglycerol Transferase (DGAT) 1 Inhibitor
        Daisuke Tomimoto; Chihiro Okuma; Yukihito Ishii; Yoshiyuki Akiyama; Takeshi Ohta; Makoto Kakutani; Yoshiaki Ohkuma; Nobuya Ogawa
        BIOLOGICAL & PHARMACEUTICAL BULLETIN, Feb. 2015, Peer-reviewed
      • Study on fatty liver disease in SDT fatty rats -the establishment of a new NASH model-
        Ishii Y; Motohashi Y; Muramatsu M; Katsuda Y; Miyajima K; Sasase T; Kume S; Yamada T; Ohta T
        Japanese Society for Animal Nutrition and Metabolism, 2015, Peer-reviewed
      • Investigation of Usefulness of Uninephrectomy in Spontaneously Diabetic torii (SDT) rats
        Maeno T; Sakakibara W; Sumikawa M; Hirao T; Yamanaka S; Chiba K; Katsuda Y; Maki M; Kemmochi Y; Tong B; Yamada T; Ohta T; Miyajima K
        Journal of Experimental Animal Technology, 2015, Peer-reviewed
      • Amp-FTA法の導入に伴う遺伝子型診断の作業効率化およびコスト削減.
        平尾直啓; 前野孝之; 龍門徳彦; 稲葉信博; 千葉薫; 笹瀬智彦; 太田毅; Tong Bin; 山田宜永
        Hokushinetsu Journal of Animal Science, 2015, Peer-reviewed
      • Effects of fenofibrate on glucose and lipid metabolism in female Spontaneously Diabetic Torii (SDT) fatty rat
        Ohta T; Motohashi Y; Katsuda Y; Ishii Y; Miyajima K; Shinohara M; Tong B; Yamada T
        Hokushinetsu Journal of Animal Science, 2015, Peer-reviewed
      • Mechanism of action of hypoglycemic effects of an intestine-specific inhibitor of microsomal triglyceride transfer protein (MTP) in obese rats
        Shohei Sakata; Sohei Katsumi; Yasuko Mera; Yukiharu Kuroki; Reiko Nashida; Makoto Kakutani; Takeshi Ohta
        JOURNAL OF PHARMACOLOGICAL SCIENCES, Jan. 2015, Peer-reviewed
      • Enhanced vascular endothelial growth factor signaling in islets contributes to beta cell injury and consequential diabetes in spontaneously diabetic Torii rats
        Eri Mukai; Takeshi Ohta; Harukiyo Kawamura; Eun-Young Lee; Asuka Morita; Tomohiko Sasase; Katsuhiro Miyajima; Nobuya Inagaki; Toshihiko Iwanaga; Takashi Miki
        DIABETES RESEARCH AND CLINICAL PRACTICE, Nov. 2014, Peer-reviewed
      • Association of a single-nucleotide polymorphism in myosin-binding protein C, slow-type (MYBPC1) gene with marbling in Japanese Black beef cattle
        Bin Tong; Seiki Sasaki; Youji Muramatsu; Takeshi Ohta; Hiroyuki Kose; Hideaki Yamashiro; Tatsuo Fujita; Takahisa Yamada
        ANIMAL GENETICS, Aug. 2014, Peer-reviewed
      • Physiological changes induced by salt intake in female Spontaneously Diabetic Torii-Lepr(fa) (SDT fatty) rat, a novel obese type 2 diabetic model
        Yoshiaki Katsuda; Yusuke Kemmochi; Mimi Maki; Ryuhei Sano; Yukihito Ishii; Katsuhiro Miyajima; Kochi Kakimoto; Takeshi Ohta
        ANIMAL SCIENCE JOURNAL, May 2014, Peer-reviewed
      • The G allele at the g.70014208A > G in the MYBPC1 gene associated with high marbling in Japanese Black cattle is at a low frequency in breeds not selected for marbling
        Bin Tong; Seiki Sasaki; Youji Muramatsu; Takeshi Ohta; Hiroyuki Kose; Tatsuo Fujita; Takahisa Yamada
        JOURNAL OF GENETICS, Apr. 2014, Peer-reviewed
      • Gender differences in metabolic disorders and related diseases in Spontaneously Diabetic Torii-Lepr(fa) rats.
        Takeshi Ohta; Yoshiaki Katsuda; Katsuhiro Miyajima; Tomohiko Sasase; Shuichi Kimura; Bin Tong; Takahisa Yamada
        Journal of diabetes research, 2014, Peer-reviewed
      • Diabetic complications in obese type 2 diabetic rat models.
        Yoshiaki Katsuda; Takeshi Ohta; Katsuhiro Miyajima; Yusuke Kemmochi; Tomohiko Sasase; Bin Tong; Masami Shinohara; Takahisa Yamada
        Experimental animals, 2014, Peer-reviewed
      • Effects of salt intake on blood pressure and renal function in Spontaneously Diabetic Torii (SDT) fatty rat
        Ohta T; Katsuda Y; Maki M; Shinohara M; Tong B; Yamada T
        Hokushinetsu Journal of Animal Science, 2014, Peer-reviewed
      • Polymorphisms of the dopamine receptor D4 gene in the Sado population of the Japanese crested ibis
        Mai YAMASHITA; Yuuta KOMATSU; Takahisa YAMADA; Bin TONG; Takeshi OHTA; Toshie SUGIYAMA; Hideaki YAMASHIRO; Yoshinori KANEKO; Hisashi NAGATA; Hiroaki IWAISAKI
        The Journal of Animal Genetics, 2014, Peer-reviewed
      • Ocular Inflammation in Uveal Tract in Aged Obese Type 2 Diabetic Rats (Spontaneously Diabetic Torii Fatty Rats)
        Yusuke Kemmochi; Katsuhiro Miyajima; Takeshi Ohta; Tomohiko Sasase; Yuzo Yasui; Kaoru Toyoda; Kochi Kakimoto; Toshiyuki Shoda; Akihiro Kakehashi
        JOURNAL OF DIABETES RESEARCH, 2014, Peer-reviewed
      • Effects of Unilateral Nephrectomy on Renal Function in Male Spontaneously Diabetic Torii Fatty Rats: A Novel Obese Type 2 Diabetic Model
        Yoshiaki Katsuda; Yusuke Kemmochi; Mimi Maki; Ryuhei Sano; Yasufumi Toriniwa; Yukihito Ishii; Katsuhiro Miyajima; Kochi Kakimoto; Takeshi Ohta
        JOURNAL OF DIABETES RESEARCH, 2014, Peer-reviewed
      • Pharmacological Effects of JTT-551, a Novel Protein Tyrosine Phosphatase 1B Inhibitor, in Diet-Induced Obesity Mice
        Makoto Ito; Sumiaki Fukuda; Shohei Sakata; Hisayo Morinaga; Takeshi Ohta
        JOURNAL OF DIABETES RESEARCH, 2014, Peer-reviewed
      • JTT-130, a Novel Intestine-Specific Inhibitor of Microsomal Triglyceride Transfer Protein, Improves Hyperglycemia and Dyslipidemia Independent of Suppression of Food Intake in Diabetic Rats
        Shohei Sakata; Makoto Ito; Yasuko Mera; Tomohiko Sasase; Hiromi Yamamoto; Makoto Kakutani; Takeshi Ohta
        JOURNAL OF DIABETES RESEARCH, 2014, Peer-reviewed
      • The nucleotide sequences for the dopamine receptor D4 gene in the Japanese crested ibis
        Yuuta KOMATSU; Mai YAMASHITA; Takahisa YAMADA; Bin TONG; Takeshi OHTA; Toshie SUGIYAMA; Hideaki YAMASHIRO; Yoshinori KANEKO; Hisashi NAGATA; Hiroaki IWAISAKI
        The Journal of Animal Genetics, 2014, Peer-reviewed
      • Combination Therapy of an Intestine-Specific Inhibitor of Microsomal Triglyceride Transfer Protein and Peroxisome Proliferator-Activated Receptor gamma Agonist in Diabetic Rat
        Shohei Sakata; Yasuko mera; Yukiharu Kuroki; Reiko Nashida; Makoto Kakutani; Takeshi Ohta
        JOURNAL OF DIABETES RESEARCH, 2014, Peer-reviewed
      • JTT-130, a Novel Intestine-Specific Inhibitor of Microsomal Triglyceride Transfer Protein, Reduces Food Preference for Fat
        Yasuko Mera; Takahiro Hata; Yukihito Ishii; Daisuke Tomimoto; Takashi Kawai; Takeshi Ohta; Makoto Kakutani
        JOURNAL OF DIABETES RESEARCH, 2014, Peer-reviewed
      • Metabolic Disorders and Diabetic Complications in Spontaneously Diabetic Torii Lepr (fa) Rat: A New Obese Type 2 Diabetic Model.
        Yusuke Kemmochi; Kenji Fukui; Mimi Maki; Shuichi Kimura; Yukihito Ishii; Tomohiko Sasase; Katsuhiro Miyajima; Takeshi Ohta
        Journal of diabetes research, 2013, Peer-reviewed
      • The spontaneously diabetic torii rat: an animal model of nonobese type 2 diabetes with severe diabetic complications.
        Tomohiko Sasase; Takeshi Ohta; Taku Masuyama; Norihide Yokoi; Akihiro Kakehashi; Masami Shinohara
        Journal of diabetes research, 2013, Peer-reviewed
      • Effects of orchidectomy on metabolism of glucose, lipid, and bone in Spontaneously Diabetic Torii (SDT) rats
        Sakakibara W; Ryumon N; Sumikawa M; Inaba M; Maeno T; Chiba K; ishii Y; Kimura S; Tong B; Ohta T; Yamada T
        Journal of Experimental Animal Technology, 2013, Peer-reviewed
      • Physiological changes by ovariectomy (OVX) in SDT rats
        Sumikawa M; Ryumon N; Inaba N; Sakakibara W; Maeno T; Chiba K; Ishii Y; Kimura S; Miyajima K; Ohta T
        Journal of Experimental Animal Technology, 2013, Peer-reviewed
      • Diabetic Peripheral Neuropathy in Spontaneously Diabetic Torii-Lepr(fa) (SDT Fatty) Rats
        Takayuki Yamaguchi; Tomohiko Sasase; Yasuko Mera; Daisuke Tomimoto; Hironobu Tadaki; Yusuke Kemmochi; Takeshi Ohta; Eimei Sato; Mutsuyoshi Matsushita
        JOURNAL OF VETERINARY MEDICAL SCIENCE, Dec. 2012, Peer-reviewed
      • Characteristics of bone turnover, bone mass and bone strength in Spontaneously Diabetic Torii-Lepr(fa) rats
        Shuichi Kimura; Tomohiko Sasase; Takeshi Ohta; Eimei Sato; Mutsuyoshi Matsushita
        JOURNAL OF BONE AND MINERAL METABOLISM, May 2012, Peer-reviewed
      • Polymorphisms in promoter regions of MYH1 and IRS1 genes showing marbling-associated expression changes.
        Tong B; Sasaki S; Muramatsu Y; Ohta T; Kose H; Yamashiro H; Yamada T
        J. Anim. Vet. Adv., 2012
      • Genetic dissection of complex genetic factor involved in NIDDM of OLETF rat.
        Takahisa Yamada; Hiroyuki Kose; Takeshi Ohta; Kozo Matsumoto
        Experimental diabetes research, 2012, Peer-reviewed
      • Effects of two kinds of laboratory animal diets on the development and progression of diabetes in SDT-fa/fa and SDT-+/+ rats
        Hirao T; Ryumon N; Inaba N; Chiba K; Sasase T; Ohta T
        Journal of Experimental Animal Technology, 2012, Peer-reviewed
      • Basic study on reproductive science in Spontaneously Diabetic Torii-Lepr fa (SDT-fa/fa) female rats
        Inaba N; Nakamura S; Hirao T; Ryumon N; Chiba K; Miyajima K; Ohta T
        Journal of Experimental Animal Technology, 2012, Peer-reviewed
      • Parathyroid Hormone (1-34) Improves Bone Mineral Density and Glucose Metabolism in Spontaneously Diabetic Torii-Lepr(fa) Rats
        Shuichi Kimura; Tomohiko Sasase; Takeshi Ohta; Eimei Sato; Mutsuyoshi Matsushita
        JOURNAL OF VETERINARY MEDICAL SCIENCE, Jan. 2012, Peer-reviewed
      • Effects of Ovariectomy on Bone Metabolism and Bone Mineral Density in Spontaneously Diabetic Torii-Lepr(fa) Rats
        Shuichi Kimura; Tomohiko Sasase; Takeshi Ohta; Mutsuyoshi Matsushita
        JOURNAL OF VETERINARY MEDICAL SCIENCE, Aug. 2011, Peer-reviewed
      • JTT-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, ameliorates impaired glucose and lipid metabolism in Zucker diabetic fatty rats
        T. Hata; Y. Mera; T. Kawai; Y. Ishii; Y. Kuroki; K. Kakimoto; T. Ohta; M. Kakutani
        DIABETES OBESITY & METABOLISM, Jul. 2011, Peer-reviewed
      • JTT-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, suppresses high fat diet-induced obesity and glucose intolerance in Sprague-Dawley rats
        T. Hata; Y. Mera; H. Tadaki; Y. Kuroki; T. Kawai; T. Ohta; M. Kakutani
        DIABETES OBESITY & METABOLISM, May 2011, Peer-reviewed
      • Blood Pressure Characteristics of Female Spontaneously Diabetic Torii-Lepr(fa) Rats
        Yukihito Ishii; Mimi Maki; Hiromi Yamamoto; Tomohiko Sasase; Makoto Kakutani; Takeshi Ohta
        JOURNAL OF VETERINARY MEDICAL SCIENCE, Apr. 2011, Peer-reviewed
      • JTT-130, a Novel Intestine-Specific Inhibitor of Microsomal Triglyceride Transfer Protein, Suppresses Food Intake and Gastric Emptying with the Elevation of Plasma Peptide YY and Glucagon-Like Peptide-1 in a Dietary Fat-Dependent Manner
        Takahiro Hata; Yasuko Mera; Yukihito Ishii; Hironobu Tadaki; Daisuke Tomimoto; Yukiharu Kuroki; Takashi Kawai; Takeshi Ohta; Makoto Kakutani
        JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Mar. 2011, Peer-reviewed
      • Effects of Food Restriction on Pancreatic Islets in Spontaneously Diabetic Torii Fatty Rats
        Yukihito Ishii; Takeshi Ohta; Tomohiko Sasase; Hisayo Morinaga; Katsuhiro Miyajima; Makoto Kakutani
        JOURNAL OF VETERINARY MEDICAL SCIENCE, Feb. 2011, Peer-reviewed
      • Cryopreservation of Spontaneously Diabetic Torii-Lepr fa (SDT-fa/fa) rat 2-cell stage embryos by simple vitrification method
        Ryumon N; Inaba N; Nakamura S; Hirao T; Maeno T; Chiba K; Sasase T; Ohta T
        Journal of Experimental Animal Technology, 2011, Peer-reviewed
      • Distribution of allele frequencies at TTN g.231054C > T, RPL27A g.3109537C > T and AKIRIN2 c.*188G > A between Japanese Black and four other cattle breeds with differing historical selection for marbling
        Naoto Watanabe; Youichi Satoh; Tatsuo Fujita; Takeshi Ohta; Hiroyuki Kose; Youji Muramatsu; Takuji Yamamoto; Takahisa Yamada
        BMC Research Notes, 2011, Peer-reviewed
      • A high-fat diet inhibits the progression of diabetes mellitus in type 2 diabetic rats
        Yukihito Ishii; Takeshi Ohta; Tomohiko Sasase; Hisayo Morinaga; Takahiro Hata; Katsuhiro Miyajima; Yoshiaki Katusda; Taku Masuyama; Masami Shinohara; Makoto Kakutani; Mutsuyoshi Matsushita
        NUTRITION RESEARCH, Jul. 2010, Peer-reviewed
      • Evaluation of Blood Pressure in Spontaneously Diabetic Torii-Lepr(fa) Rats
        Yukihito Ishii; Mimi Maki; Hiromi Yamamoto; Tomohiko Sasase; Makoto Kakutani; Takeshi Ohta
        EXPERIMENTAL ANIMALS, Jul. 2010, Peer-reviewed
      • Pharmacological profiles of a novel protein tyrosine phosphatase 1B inhibitor, JTT-551
        S. Fukuda; T. Ohta; S. Sakata; H. Morinaga; M. Ito; Y. Nakagawa; M. Tanaka; M. Matsushita
        DIABETES OBESITY & METABOLISM, Apr. 2010, Peer-reviewed
      • Pathophysiological Analysis of Female Spontaneously Diabetic Torii Fatty Rats
        Yukihito Ishii; Takeshi Ohta; Tomohiko Sasase; Hisayo Morinaga; Nobuhisa Ueda; Takahiro Hata; Makoto Kakutani; Katsuhiro Miyajima; Yoshiaki Katsuda; Taku Masuyama; Masami Shinohara; Mutsuyoshi Matsushita
        EXPERIMENTAL ANIMALS, Jan. 2010, Peer-reviewed
      • Protein kinase C beta inhibitor prevents diabetic peripheral neuropathy, but not histopathological abnormalities of retina in Spontaneously Diabetic Torii rat
        T. Sasase; H. Morinaga; T. Abe; K. Miyajima; T. Ohta; M. Shinohara; M. Matsushita; A. Kakehashi
        DIABETES OBESITY & METABOLISM, Nov. 2009, Peer-reviewed
      • Pancreatic Function of Spontaneously Diabetic Torii Rats in Pre-Diabetic Stage
        Kenichi Matsui; Tomohiro Oda; Emiko Nishizawa; Ryuhei Sano; Hiromi Yamamoto; Sumiaki Fukuda; Tomohiko Sasase; Katsuhiro Miyajima; Nobuhisa Ueda; Yukihito Ishii; Takeshi Ohta; Mutsuyoshi Matsushita
        EXPERIMENTAL ANIMALS, Jul. 2009, Peer-reviewed
      • Effects on a high-sucrose diet in Goto-Kakizaki rats, a genetic model of nonobese type 2 diabetes.
        Ohta T; Miyajima K; Yamada T
        J. Med., 2009, Peer-reviewed
      • Association of a single nucleotide polymorphism in titin gene with marbling in Japanese Black beef cattle
        Takahisa Yamada; Seiki Sasaki; Shin Sukegawa; Sachiyo Yoshioka; Youichi Takahagi; Mitsuo Morita; Hiroshi Murakami; Fumiki Morimatsu; Tatsuo Fujita; Takeshi Miyake; Yoshiyuki Sasaki
        BMC Research Notes, 2009, Peer-reviewed
      • Effect of Food Restriction on Adipose Tissue in Spontaneously Diabetic Torii Fatty Rats
        Hisayo Morinaga; Takeshi Ohta; Kenichi Matsui; Tomohiko Sasase; Sumiaki Fukuda; Makoto Ito; Masatoshi Ueda; Yukihito Ishii; Katsuhiro Miyajima; Mutsuyoshi Matsushita
        EXPERIMENTAL DIABETES RESEARCH, 2009, Peer-reviewed
      • Characterization of Hepatic Glucose Metabolism Disorder with the Progress of Diabetes in Male Spontaneously Diabetic Torii Rats
        Hisayo Morinaga; Hiromi Yamamoto; Kaoru Sakata; Sumiaki Fukuda; Makoto Ito; Tomohiko Sasase; Katsuhiro Miyajima; Nobuhisa Ueda; Takeshi Ohta; Mutsuyoshi Matsushita
        JOURNAL OF VETERINARY MEDICAL SCIENCE, Nov. 2008, Peer-reviewed
      • Effects of preventing hyperphagia on glycolipid metabolic abnormalities in Spontaneously Diabetic Torii fatty rats
        Kenichi Matsui; Takeshi Ohta; Hisayo Morinaga; Tomohiko Sasase; Sumiaki Fukuda; Makoto Ito; Masatoshi Ueda; Naoto Ogawa; Katsuhiro Miyajima; Mutsuyoshi Matsushita
        ANIMAL SCIENCE JOURNAL, Oct. 2008, Peer-reviewed
      • Diabetes-associated complications in Spontaneously Diabetic Torii fatty rats
        Kenichi Matsui; Takeshi Ohta; Tomohiro Oda; Tomohiko Sasase; Nobuhisa Ueda; Katsuhiro Miyajima; Taku Masuyama; Masami Shinohara; Mutsuyoshi Matsushita
        EXPERIMENTAL ANIMALS, Apr. 2008, Peer-reviewed
      • A high-sucrose diet induces fatty liver, but not deterioration of diabetes mellitus in Zucker Diabetic Fatty rats.
        Ohta T; Miyajima K; Yamada T
        Res. Commun. Mol. Pathol. Pharmacol., 2008, Peer-reviewed
      • Effect of insulin therapy on renal changes in spontaneously diabetic torii rats
        Takeshi Ohta; Kenichi Matsui; Katsuhiro Miyajima; Tomohiko Sasase; Taku Masuyama; Toshiyuki Shoda; Haruko Koizumi; Masarni Shinohara; Mutsuyoshi Matsushita
        EXPERIMENTAL ANIMALS, Oct. 2007, Peer-reviewed
      • Increased fat absorption and impaired fat clearance cause postprandial hypertriglyceridemia in Spontaneously Diabetic Torii rat
        Tomohiko Sasase; Hisayo Morinaga; Hiromi Yamamoto; Naoto Ogawa; Kenichi Matsui; Katsuhiro Miyajima; Takashi Kawai; Yasuko Mera; Taku Masuyama; Masami Shinohara; Takeshi Ohta; Mutsuyoshi Matsushita
        DIABETES RESEARCH AND CLINICAL PRACTICE, Oct. 2007, Peer-reviewed
      • Preventive effects of glycaemic control on ocular complications of Spontaneously Diabetic Torii rat
        T. Sasase; T. Ohta; N. Ogawa; K. Miyajima; M. Ito; H. Yamamoto; H. Morinaga; M. Matsushita
        DIABETES OBESITY & METABOLISM, Sep. 2006, Peer-reviewed
      • Daily inhibition of postprandial hyperglycaemia with JTT-608, a novel oral antidiabetic agent, ameliorates pancreatic function in neonatally streptozotocin-treated rats
        T Ohta; T Sasase; K Miyajima; K Matsui; M Matsushita; N Furukawa; F Yonemori
        DIABETES OBESITY & METABOLISM, Sep. 2005, Peer-reviewed
      • Antidiabetic effect of chronic administration of JTT-608, a new hypoglycemic agent, in diabetic Goto-Kakizaki rats
        T Ohta; K Miyajima; G Komuro; N Furukawa; F Yonemori
        EUROPEAN JOURNAL OF PHARMACOLOGY, Aug. 2003, Peer-reviewed
      • A novel enhancer of insulinotrophic action by high glucose (JTT-608) stimulates insulin secretion from pancreatic beta-cells via a new cellular mechanism
        N Itabashi; K Okada; S Muto; N Fujita; T Ohta; JI Miyazaki; Y Asano; T Saito
        JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Jun. 2001, Peer-reviewed
      • The insulinotropic mechanism of the novel hypoglycaemic agent JTT-608: direct enhancement of Ca2+ efficacy and increase of Ca2+ influx by phosphodiesterase inhibition
        E Mukai; H Ishida; S Fujimoto; M Kajikawa; Y Okamoto; J Fujita; Y Hamamoto; Y Tsuura; Y Yamada; N Furukawa; T Ohta; Y Seino
        BRITISH JOURNAL OF PHARMACOLOGY, Mar. 2000, Peer-reviewed
      • JTT-608 restores impaired early insulin secretion in diabetic Goto-Kakizaki rats
        T Ohta; N Furukawa; G Komuro; F Yonemori; K Wakitani
        BRITISH JOURNAL OF PHARMACOLOGY, Apr. 1999, Peer-reviewed
      • Glucose-dependent insulinotropic effects of JTT-608, a novel antidiabetic compound
        N Furukawa; T Ohta; T Noguchi; F Yonemori; K Wakitani
        EUROPEAN JOURNAL OF PHARMACOLOGY, Apr. 1999, Peer-reviewed
      • JTT-608 controls blood glucose by enhancement of glucose-stimulated insulin secretion in normal and diabetes mellitus rats
        T Ohta; N Furukawa; F Yonemori; K Wakitani
        EUROPEAN JOURNAL OF PHARMACOLOGY, Feb. 1999, Peer-reviewed
      • 4-(trans-4-methylcyclohexyl)-4-oxobutyric acid (JTT-608). A new class of antidiabetic agent
        H Shinkai; H Ozeki; T Motomura; T Ohta; N Furukawa; Uchida, I
        JOURNAL OF MEDICINAL CHEMISTRY, Dec. 1998, Peer-reviewed
      • The relative growth of the follicle and oocyte in the ovary of the pig, wild boar and the crossbred of pig x wild boar
        Miyamoto H; Ohta T
        Japanese journal of animal reproductive technology, 1990, Peer-reviewed

      Misc.

      • 高ショ糖/高脂肪/高コレステロール食給餌が肥満2型糖尿病モデルマウスdb/dbマウス、およびKK-Ayマウスの肝臓に及ぼす影響
        白坂航大; 武呂大和; 筒井誉大; 小郷智記; 宇野絹子; 万代康平; 杉本実紀; 笹瀬智彦; 篠原雅巳; 美谷島克宏; 太田毅
        日本畜産学会130回大会講演要旨, Sep. 2022, Last author, Corresponding author
      • Pathophysiological analysis of kidney and comparison of male and female SDT fatty rats, an obese model of type 2 diabetes mellitus, fed a high sucrose and high fat diet
        Watanabe K; Miyajima K; Mandai K; Sekiguti K; Kemuriyama N; Sasase T; Watanabe T; Ito H; Shinohara M; Ohta T
        The 4th International Seminar on Smart Molecule of Natural Resources (ISSMART) 2022 ABSTRACT BOOK, Aug. 2022, Last author
      • 高ショ糖/高脂肪食給餌における肥満2型糖尿病モデルSDT fatty ラットの腎臓の病態解析と雌雄比較
        渡邊果奈; 美谷島克宏; 万代康平; 関口敬大; 宇野絹子; 煙山紀子; 笹瀬智彦; 渡辺寿久; 伊藤秀樹; 篠原雅巳; 中江大; 太田毅
        第49回日本毒性学会講演要旨, Jun. 2022
      • SDT fatty rat 糖尿病網膜症に対するペマフィブラートの効果
        田中克明; 高; 木理那; 御任真言; 榛村真智子; 長谷川哲也; 染谷省吾; 篠原雅巳; 影山靖; 笹瀬智彦; 太田毅; 村松慎一; 梯彰弘; 蕪城俊克
        Journal of Japanese Ophthalmological Society, Mar. 2022
      • Effect of high sucrose/high fat diet on the kidneys in obese type 2 diabetes model SDT fatty rats
        Watanabe K; Miyajima K; Mandai K; Seiguti K; Uno K; Kemuriyama N; Sasase T; Watnabe T; Ito H; Shinohara M; Nakae D; Ohta T
        The 38th Annual Meeting of the Japanese Society of Toxicologic Pathology, Jan. 2022, Last author
      • Involvement of glucagon in pathophysiology of type 2 diabetic animal model
        Mandai k; Miyajima K; Watanabe K; Ishizuka K; Uno K; Kemuriyama N; Shinohara M; Sasase T; Watanabe T; Ito H; Shinohara M; Ohta T; Nakae D
        The 38th Annual Meeting of the Japanese Society of Toxicologic Pathology, Jan. 2022
      • Analysis of ACE2 expression in type2 diabetic rats; SDT and SDT fatty rats
        Hatanaka Y; Miyajima K; Uno K; Tohma M; Hanh Nhung N; Kemuriyama N; Watanabe T; Ito H; Shinohara M; Sasase T; Ohta T; Nakae D
        The 38th Annual Meeting of the Japanese Society of Toxicologic Pathology, Jan. 2022
      • 肥満2型糖尿病モデルSDT fattyラットの糖尿病性腎臓病早期におけるダパグリフロジンの腎保護効果の検討
        篠原雅巳; 黒木楓子; 杉本実紀; 佐野龍平; 美谷島克宏; 中江大; 太田毅
        第32回日本糖尿病性腎症研究会プログラム・抄録集, Dec. 2021, Last author
      • 高ショ糖/高脂肪食給餌が肥満2型糖尿病モデルSDT fatty ラットの腎臓に及ぼす影響について
        渡邊果奈; 美谷島克宏; 万代康平; 関口敬大; 煙山紀子; 笹瀬智彦; 渡辺寿久; 伊藤秀樹; 篠原雅巳; 中江大; 太田毅
        第32回日本糖尿病性腎症研究会プログラム・抄録集, Dec. 2021, Last author
      • 高ショ糖/高脂肪食給餌が肥満2型糖尿病モデルマウスdb/dbマウスおよびKK-Ayマウスの腎臓に及ぼす影響
        筒井誉大; 万代康平; 宇野絹子; 関口敬大; 白坂航大; 武呂大和; 杉本実紀; 篠原雅巳; 美谷島克宏; 笹瀬智彦; 太田毅
        第32回日本糖尿病性腎症研究会プログラム・抄録集, Dec. 2021, Last author
      • 2型糖尿病モデル動物におけるサルコペニアの病態解析
        太田毅; 篠原雅巳; 剣持佑介; 前川竜也; 万代康平; 石塚佳菜; 美永谷島克宏; 山田宜永
        第36回日本糖尿病合併症学会 プログラム・抄録集, Oct. 2021, Lead author, Corresponding author
      • Brain abnormalities in Spontaneously Diabetic Torii-Leprfa (SDT fatty) rats
        Maekawa T; Sasase T; Shinohara M; Kume S; Ohta T
        AIP Proceedings, Oct. 2021, Peer-reviewed, Last author
      • 肥満2型糖尿病モデルマウスの空腸における病態生理学的解析
        西田芽衣; 黒木楓子; 小郷智記; 笹瀬智彦; 杉本実紀; 宇野絹子; 美谷島克宏; 太田毅
        日本畜産学会第129回大会講演要旨, Sep. 2021
      • Regulation of fatty acid biosynthesis in liver through GPR52 signaling
        Wada M; Yukawa K; Ogasawara H; Suzawa K; Maekawa T; Yamamoto Y; Ohta T; Lee E; Miki T
        The Journal of Physiological Sciences, Aug. 2021, Peer-reviewed
      • The relationship of plasma cholesterol and atherosclerotic lesions in congenic spontaneously hyperlipidemic mice
        Tadaki T; Sasase T; Maekawa T; Yamada T; Ohta T
        The 3rd International Seminar on Smart Molecule of Natural Resources (ISSMART) - Asian Federation of Biotechnology (AFOB), Aug. 2021
      • Brain abnormalities in Spontaneously Diabetic Torii-Leprfa (SDT fatty) rats
        Maekawa T; Sasase T; Shinohara M; Kume S; Ohta T
        The 3rd International Seminar on Smart Molecule of Natural Resources (ISSMART) - Asian Federation of Biotechnology (AFOB), Aug. 2021
      • Analysis of ACE2 expression in SDT fatty rats
        Uno K; Miyajima K; Ishida Y; Yamaguchi A; Mandai K; Uechi T; Shinohra M; Sasase T; Ohta T; Kemuriyama N; Nakae D
        第48回日本毒性学会講演要旨, Jul. 2021
      • Effect of high fat diet on liver in db/db and KK-Ay mice
        Mandai K; Miyajima K; Kitamura S; Yamaguchi A; Uno K; Kuroki F; Nishida M; Shirasaka K; Tsustui T; Muro Y; Sugimoto M; Kemuriyama H; Shinohara M; Sasase T; Ohta T; Nakae D
        第48回日本毒性学会講演要旨, Jul. 2021
      • 肥満2型糖尿病モデルSDT fattyラットにおける糖尿病性腎症初期病変の検討
        黒木楓子; 杉本実紀; 佐野龍平; 美谷島克宏; 中江大; 篠原雅巳; 太田毅
        Kansai Journal of Animal Science, Mar. 2021
      • 肥満2型糖尿病動物の末梢血管障害に関する検討
        太田毅; 村井康高; 篠原雅巳; 山田宜永
        Kansai Journal of Animal Science, Mar. 2021
      • ウシ桑実胚でのヒストンメチル化プロファイリングおよびMAT2Aの寄与の解析
        太田愛理; 池田俊太郎; 篠澤章久; 岩田尚孝; 杉本実紀; 久米新一; 南直治郎; 太田毅
        Kansai Journal of Animal Science, Mar. 2021
      • 新生仔マウスへのビタミンA補給による腸管、胸腺、脾臓の発育に対する影響の検討
        仲野彰紘; 水永武寿; 太田毅; 杉本実紀
        Kansai Journal of Animal Science, Mar. 2021
      • ウシ初期胚におけるヒストンメチル化修飾への外因性メチオニンの関与
        太田愛理; 池田俊太郎; 杉本実紀; 南直治郎; 太田毅
        The Journal of Reproduction and Development, Sep. 2020
      • Hemodynamics in the obese type 2 diabetic model Spontaneously Diabetic Torii Leprfa (SDT fatty) rats
        Sasase T; Murai Y; Tadaki H; Shinohara M; Yamada T; Ohta T
        2nd International Seminar Smart Molecular of Natural Resources (ISSMART2020) Abstract, Aug. 2020
      • The glucose sensing insulin secretion with hyperglycemic clamp technique in Sprague Dawley rats
        Tadaki H; Sasase T; Toriniwa Y; Yamada T; Ohta T
        2nd International Seminar Smart Molecular of Natural Resources (ISSMART2020) Abstract, Aug. 2020
      • 糖尿病モデル動物であるSDT fattyラットにおけるCDAA食ならびにHF食の肝臓及び脂肪組織に及ぼす影響
        万代康平; 美谷島克宏; 山口彩音; 山本敦也; 町田七海; 森田菜穂; 岩本健志郎; 煙山紀子; 篠原雅巳; 太田毅; 中江大
        The Journal of Toxicological Sciences, Jun. 2020
      • 2型糖尿病モデルdb/dbおよびKK-Ayマウスの腎臓における高脂肪食摂餌の影響
        山口彩音; 美谷島克宏; 宇野絹子; 杉本実紀; 黒木楓子; 西田芽衣; 小郷智記; 煙山紀子; 篠原雅巳; 中江大; 太田毅
        The Journal of Toxicological Sciences, Jun. 2020
      • 糖尿病モデル動物の最適化ー病態の特徴把握と発症早期化に向けてー
        太田毅
        第67回日本実験動物学会講演要旨集, May 2020
      • メチレンテトラヒドロ葉酸還元酵素(MTHFR)の胚盤胞発生への寄与について
        石谷洋希; 池田俊太郎; 杉本実紀; 南直治郎; 太田毅
        日本生殖医学会雑誌, Apr. 2020
      • 肥満2型糖尿病モデル動物の骨格筋における病態生理学的変化の検討
        太田毅; 剣持佑介; 篠原雅巳; 山田宜永
        Kansai Journal of Animal Science, Mar. 2020
      • SDT fattyラットに認められた糖尿病・肥満サルコペニアについて
        篠原雅巳; 剣持佑介; 太田毅; 山田宜永
        34th Japan Society of Experimental Diabetes and Obesity program & abstracts, Feb. 2020
      • Investigation of pathological changes in kidney and heart in dead SDT fatty rats
        Yamaguchi A; Miyajima K; Hashimoto A; Kemuriyama N; Shinohara M; Ohta T; Nakae D
        The 36th Annual Meeting of the Japanese Society of Toxicologic Pathology, Feb. 2020
      • The uni-nephrectomized and salt-loaded SDT fatty rat, a novel type 2 diabetic model of diabetic nephropathy, develops features of diabetic retinopathy
        Masami Shinohara; Francois Briand; Sophie Antoneli; Virginie Mauro; Nicolas Cimbolini; Emmanuel Brousseau; Takeshi Ohta; Katsuhiro Miyajima; Yasushi Kageyama; Laurence Feraille; Thierry Sulpice
        The 36th Annual Meeting of the Japanese Society of Toxicologic Pathology, Feb. 2020
      • 肥満2型糖尿病モデルSDT fattyラットの腎臓におけるSGLT2の発現および病態の解析
        篠原 雅巳; 張 舜恵; 宇野 絹子; 山口 彩音; 太田 毅; 美谷島 克宏
        第31回日本糖尿病性腎症研究会プログラム・抄録集, Dec. 2019
      • DapagliflozinあるいはDapagliflozinとRamiprilの併用投与が 糖尿病モデルSDT fatty ラットの腎症に及ぼす影響
        太田毅; Francois Briand; 篠原雅巳; 笹瀬智彦; Emmanuel Brousseau; 影山靖; Thierry Sulpice
        第31回日本糖尿病性腎症研究会プログラム・抄録集, Dec. 2019
      • 糖尿病モデル動物におけるコレステロール負荷によるNASH様病変増悪化の検討
        太田 毅; 鳥庭 靖文; 美谷島 克宏; 篠原 雅巳; 山田 宜永
        第68回北信越畜産学会要旨, Oct. 2019
      • 肥満2型糖尿病モデルSDT fatty ラットにおける糖尿病黄斑浮腫様変化の病態生理学的解析
        太田毅; 本橋雄; 笹瀬智彦; 剣持佑介; 前川竜也; 唯木洋暢; 田中克明; 梯彰弘; 篠原雅巳; 山田宜永
        日本畜産学会第126回大会講演要旨, Sep. 2019
      • 肥満2型糖尿病モデルSDT fattyラットにおけるDapagliflozin単剤およびRamiprilとの併用投与による腎症改善効果の検討
        太田毅; Francois Briand; 篠原雅巳; 笹瀬智彦; Emmanuel Brousseau; 影山靖; Thierry Sulpice
        第34回日本糖尿病合併症学会プログラム・抄録集, Sep. 2019
      • ウシ初期胚のヒストンメチル化におけるメチオニンアデノシルトランスフェラーゼの役割
        太田愛理; 池田俊太郎; 杉本実紀; 南直治郎; 太田毅
        The Journal of Reproduction and Development, Sep. 2019
      • TNF-α Converting Enzyme (TACE) Inhibitor: A New Approach to Prevent Development of Diabetes
        Tomohiko Sasase; Mariko Maekawa; Hironobu Tadaki; Daisuke Tomimoto; Chihiro Okuma; Ryuhei Sano; Yukihito Ishii; Yoshiaki Katsuda; Hiromi Yoshiuchi; Reina Kakefuda; Takeshi Ohta
        6th International Conference on Advance Molecular Bioscience and Biomedical Engineering (ICAMBBE) Abstract, Aug. 2019
      • Pathological features of diabetic retinopathy in unilaterally nephrectomized Spontaneously Diabetic Torii fatty rats given 0.3% salt water.
        Tanaka Y; Takagi R; Shimmura-Tomita M; Yamaguchi F; Katayama Y; Suzuki T; Shinohara M; Ohta T; Sasase T; Kakehashi A
        Invest. Ophthalmol. Vis. Sci., Jul. 2019, Peer-reviewed
      • Age-related anatomical changes in the cornea of spontaneous type 2 diabetes model rats.
        Shimmura-Tomita M; Takano H; Kinoshita N; Tanaka Y; Takagi R; Kobayashi M; Ohta T; Sasase T; Shinohara M; Kakehashi A
        Invest. Ophthalmol. Vis. Sci., Jul. 2019, Peer-reviewed
      • 肥満2型糖尿病モデル雌性SDT fattyラットにおける加齢に伴う腎病変の変化
        篠原雅巳; Teoh Soon Hui; 美谷島克宏; 太田毅; 中江大
        第19回日本抗加齢医学会講演要旨, Jun. 2019
      • 片腎摘出・0.3%食塩負荷SDT fattyラットに発症する糖尿病網膜症の免疫組織化学的検討
        田中克明; 高木理那; 榛村真智子; 山口忠成; 片山裕子; 鈴木智久; 篠原雅巳; 太田毅; 笹瀬智彦; 梯彰弘
        第123回日本眼科学会講演要旨, Apr. 2019
      • SDT fattyラットにおける片腎摘出術および食塩負荷が糖尿病網膜症進展に及ぼす影響について
        篠原雅巳; Francois Briand; Sophie Antoneli; Virginie Mauro; Nicolas Cimbolini; Emmanuel Brousseau; 太田毅; 影山靖; Laurence Feraille; Thierry Sulpice
        Japan Society of Experimental Diabetes and Obesity Program & Abstracts, Mar. 2019
      • Chronological changes of serum parameters in the course of Nonalcoholic Steatohepatitis-like lesion in female SDT fatty rats
        Kanjiro Ryu; Katsuhiro Miyajima; Teoh Soon Hui; Masami Shinohara; Takeshi Ohta; Keiichi Ohata; Kinuko Uno; Noriko Kemuriyama; Shuji Ogawa; Astushi Watanabe; Dai Nakae
        第35回日本毒性病理学会講演要旨, Jan. 2019
      • 食塩負荷が肥満2型糖尿病モデルSDT fattyラットの腎症進展に及ぼす影響
        篠原雅巳; 美谷島克宏; 太田毅; 岩崎日向子; 張舜恵; 宇野絹子; 煙山紀子; 中江大
        第30回日本糖尿病性腎症研究会プログラム・抄録集, Dec. 2018
      • 肥満2型糖尿病モデルSDT fattyラットにおける末梢神経障害の検討
        篠原雅巳; 太田毅; 前川竜也; 唯木洋暢; 笹瀬智彦; 本橋雄; 美谷島克宏; 久米新一
        第33回日本糖尿病合併症学会プログラム・抄録集, Oct. 2018
      • Induction by Western Diets of Nonalcoholic Steatohepatitis-like lesions in insulin-resistant Zucker fatty rats
        Kinuko Uno; Katsuhiro Miyajima; Takeshi Ohta; Tomoyuki Saito; Yasufumi Toriniwa; Soon Hui Teoh; Yuki Shirai; Shuji Ogawa; Atsushi Watanabe; Noriko Kemuriyama; Dai Nakae
        第45回日本毒性学会講演要旨, Jul. 2018
      • Chronological changes of biomarkers related to process of the Nonalcoholic Steatohepatitis like lesions in female SDT fatty rats
        Kanjiro Ryu; Katsuhiro Miyajima; Teoh Soon Hui; Masami Shinohara; Takeshi Ohta; Keiichi Ohata; Kinuko Uno; Noriko Kemuriyama; Shuji Ogawa; Atsushi Watanabe; Dai Nakae
        第45回日本毒性学会講演要旨, Jul. 2018
      • The uni-nephrectomized SDT fatty rats, a novel type 2 diabetic model of diabetic nephropathy, develops features of diabetic retinopathy over 10 weeks.
        Briand F; Antonelli S; Mauro V; Cimbolini N; Shinohara M; Brousseau E; Ohta T; Kageyama Y; Feraille L; Sulpice T
        Invest. Ophthalmol. Vis. Sci., Jul. 2018, Peer-reviewed
      • Pathological features of diabetic retinopathy in Spontaneously Diabetic Torii fatty rats.
        Tanaka Y; Kobayashi M; Takagi R; Uehara S; Toyoda F; Shimmura-Tomita M; Kinoshita N; Takano H; Ohta T; Sasase T; Kakehashi A
        Invest. Ophthalmol. Vis. Sci., Jul. 2018, Peer-reviewed
      • Corneal inflammation in a spontaneous type 2 diabetes model rat.
        Shimmura-Tomita M; Takano H; Kinoshita N; Toyoda F; Tanaka Y; Uehara S; Takagi R; Kobayashi M; Ohta T; Sasase T; Kakehashi A
        Invest. Ophthalmol. Vis. Sci., Jul. 2018, Peer-reviewed
      • SDT fattyラットに発症する糖尿病網膜症の免疫組織化学的検討
        田中克明; 小林未奈; 高木理那; 上原志保; 豊田文彦; 榛村真知子; 木下望; 高野博子; 太田毅; 笹瀬智彦; 梯彰弘
        第122回日本眼科学会講演要旨, Apr. 2018
      • 自然発症2型糖尿病モデルラットにおける角膜炎症
        榛村真知子; 高野博子; 木下望; 豊田文彦; 田中克明; 上原志保; 高木理那; 小林未奈; 太田毅; 笹瀬智彦; 梯彰弘
        第122回日本眼科学会講演要旨, Apr. 2018
      • 肥満2型糖尿病モデルSDT fattyラットの末梢神経障害に関する検討
        太田毅; 前川竜也; 前川竜也; 唯木洋暢; 笹瀬智彦; 本橋雄; 美谷島克宏; 美谷島克宏; 久米新一
        日本畜産学会大会講演要旨, 28 Mar. 2018
      • Histopathological analysis of young and aged female SDT fatty rats
        Teoh SH; Miyajima K; Ohta T; Shinohara M; Uno K; Kemuriyama N; Nakae D
        The 34th Annual Meeting of the Japanese Society of Toxicologic Pathology, Jan. 2018
      • Effect of NaCl supplementation on renal complications in SDT fatty rat
        Miyajima K; Ohta T; Shinohara M; Iwasaki H; Teoh SH; Uno K; Kemuriyama N; Nakae D
        The 34th Annual Meeting of the Japanese Society of Toxicologic Pathology, Jan. 2018
      • Pathophysiological evaluation of the liver in Western diets insulin resistant Zucker fatty rats.
        Maekawa M; Sasase T; Saito T; Toriniwa Y; Ishii Y; Uemura A; Miyajima K; Uno K; Shirai Y; Nakae D; Ohta T
        5th ICAMBBE, 2018
      • Pathophysiological changes in salt loaded female Spontaneously Diabetic Torii (SDT) fatty rats.
        Teoh SH; Miyajima K; Shinohara M; Briand F; Nakae D; Ohta T
        5th ICAMBBE, 2018
      • Effects of the loading of excessive sodium chloride on the pathosis mimicking type 2 diabetes mellitus in spontaneously diabetic torii (SDT) fatty rats.
        Teoh SH; Miyajima K; Ohta T; Nakae D
        Global Meeting on Diabetes and Endocrinology 2018, 2018
      • Dapagliflozin alone or combination with ramipril improves hyperglycemia, hypertension, and prevents kidney complications and GFR decline in the nephrectomized SDT fatty rat model of diabetic nephropathy.
        Briand F; Shinohara M; Brousseau E; Ohta T; Kageyama Y; Sulpice T
        ISN Frontiers Meetings 2018, 2018, Peer-reviewed
      • Involvement of glucotoxicity on peripheral neuropathy in SDT fatty rats, a new animal model of obese type 2 diabetes.
        Mekawa T; Tadaki H; Sasase T; Motohashi Y; Miyajima K; Ohta T; Kume S
        Society of Toxicology, 57th Annual Meeting and ToxExpo, 2018, Peer-reviewed
      • Non-obese type 2 diabetic rat models – GK rat and SDT rat –
        Ohta T; Sasase T; Gotoh T; Shinohara M; Sirichaiyakul P; Furuta S; Udomrak L; Kamiya T; Yamada T
        Open J. Anim. Sci., 2018
      • 新規糖尿病性腎症モデルの作製と病態解析:SDT fattyラットの腎症進展に対する片腎摘出および食塩負荷の影響
        篠原雅巳; Francois Briand; Emmanuel Brousseau; 太田毅; 美谷島克宏; 影山靖; Thierry Sulpice
        第29回日本糖尿病性腎症研究会プログラム・抄録集, Dec. 2017
      • 片腎摘出および食塩負荷が肥満2型糖尿病モデルSDT fattyラットの腎症進展に与える影響
        篠原雅巳; Francois Briand; Emmanuel Brousseau; 太田毅; 美谷島克宏; 影山靖; Thierry Sulpice
        第32回日本糖尿病合併症学会プログラム・抄録集, Oct. 2017
      • SDT fatty ratにおける糖尿病網膜症
        田中克明; 小林未奈; 高木理那; 上原志保; 豊田文彦; 榛村真知子; 木下望; 高野博子; 太田毅; 笹瀬智彦; 梯彰弘
        第32回日本糖尿病合併症学会プログラム・抄録集, Oct. 2017
      • Histological analysis of young and aged female Spontaneously Diabetic Torii fatty rats
        Teoh SH; Miyajima K; Ohta T; Shinohara M; Uno K; Kemuriyama N; Nakae D
        ABSTRACT BOOK ICAMBBE2017, Sep. 2017
      • Drug therapy in type 2 diabetes and obesity - Monoacylglycerol Acyltransferase (MGAT) inhibitor
        Ohta T
        ABSTRACT BOOK ICAMBBE2017, Sep. 2017
      • Diabetic peripheral neuropathy in SDT fatty rat, a new animal model of obese type2 diabetes.
        Maekawa T; tadaki H; Motohashi Y; Miyajima K; Ohta T; Kume S
        NEURODIAB2017, Sep. 2017, Peer-reviewed
      • SDT fattyラットにおける12週間の0.3%食塩負荷が2型糖尿病様病態進展に及ぼす影響
        張舜恵; 美谷島克宏; 太田毅; 篠原雅巳; 新里珠美; 宇野絹子; 煙山紀子; 中江大
        第44回日本毒性学会講演要旨, Jul. 2017
      • SDT fattyラットにおける片腎摘出及び食塩負荷が腎症進展に及ぼす影響―慢性腎臓病モデルの確立に向けて―
        太田毅; 篠原雅巳; BRIAND Francois; BROUSSEAU Emmanuel; 美谷島克宏; 影山靖; 勝田佳朋; 久米新一; SULPICE Thierry
        日本畜産学会大会講演要旨, 28 Mar. 2017
      • SDT fattyラットにおける片腎摘出術および食塩負荷が腎症進展に及ぼす影響:糖尿病性腎症モデルの作製と病態解析
        篠原雅巳; Francois Briand; Emmanuel Brousseau; 太田毅; 美谷島克宏; 影山靖; Thierry Sulpice
        Japan Society of Experimental Diabetes and Obesity Program & Abstracts, Feb. 2017
      • Early onset of preliminary changes that progress into NASH-like lesions in STAM mice
        Miyajima K; Ohta T; Ishii Y; Suzuki-Kemuriyama N; Nakae D
        The 33rd Annual Meeting of the Japanese Society of Toxicologic Pathology, Jan. 2017
      • Dapagliflozin treatment improves severe renal impairment in Uninephrectomized SDT fatty rat, a 10-week model of advanced renal complications and glomerular filtration rate decline.
        Briand F; Shinohara M; Brousseau E; Ohta T; Kageyama Y; Sulpice T
        54th ERA-EDTA CONGRESS, MADRID 2017, 2017, Peer-reviewed
      • 10-week, but not 7-week, Dapagliflozin treatment improves severe renal impairment in the Uninephrectomized SDT fatty rat, a 10-week model of advanced renal complications and glomerular filtration rate decline.
        Briand F; Shinohara M; Brousseau E; Ohta T; Kageyama Y; Sulpice T
        ISN World Congress of Nephrology 2017, 2017, Peer-reviewed
      • Pathophysiological analyses of skeletal muscle in obese type 2 diabetes Spontaneously Diabetic Torii (SDT) fatty rats.
        Kemmochi Y; Ohta T; Kaneshige A; Katsumi S; Taniai-Riya E; Toyoda K; Anagawa-Nakamura A; Yasui Y; Takahashi A; Kakimoto K; Shoda T; Yamada T
        Society of Toxicologic Pathology, 36th Annual Sympojium, 2017, Peer-reviewed
      • Dapagliflozin alone or combined with ramipril improves hyperglycemia and hypertension and prevents kidney complications and GFR decline in the nephrectomized SDT fatty rat model of diabetic nephropathy.
        Briand F; Shinohara M; Brousseau E; Ohta T; Kageyama Y; Sulpice T
        J. Am. Soc. Nephrol., 2017, Peer-reviewed
      • 肥満2型糖尿病モデルSDT fattyラットに食塩負荷が及ぼす病態生理学的変化について
        篠原雅巳; 太田毅; 勝田佳朋; 剣持佑介; 槇美実; 佐野龍平; 石井幸仁; 美谷島克宏; 柿本恒知
        第28回日本糖尿病性腎症研究会プログラム・抄録集, Dec. 2016
      • 非アルコール性脂肪性肝炎(NASH)モデルであるSTAMマウスモデルの早期病変に関する病態解析
        美谷島克宏; 太田毅; 石井幸仁; 煙山紀子; 中江大
        第31回発癌病理研究会講演要旨, Aug. 2016
      • Maternal high-fat diet promotes onset of diabetes in rat offspring
        Ohta T; Toriniwa Y; Ryumon N; Inaba N; Hirao T; Yamanak S; Maeno T; Sakakibara; Sumikawa M; Chiba K; Nakamura A; Miyajima K; Fatchiyah F; Yamada T
        ABSTRACT BOOK ICAMBBE2016, Aug. 2016
      • Long-Term Glycemic Control with Insulin Prevents the Development of Testicular Interstitial Cell Tumors in Spontaneously Diabetic Torii Rats
        Takeshi Ohta; Yusuke Kemmochi; Katsuhiro Miyajima; Tomohiko Sasase; Kenichi Matsui; Nobuhisa Ueda; Masami Shinohara; Mutsu-Yoshi Matsushita
        DIABETES, Jun. 2016, Peer-reviewed
      • 新規肥満2型糖尿病モデル雌性SDT fattyラットにおけるNASH様病変の解析
        太田毅; 石井幸仁; 本橋雄; 村松真; 勝田佳朋; 美谷島克宏; 笹瀬智彦; 山田宜永; 松井徹; 篠原雅巳; 久米新一
        日本畜産学会大会講演要旨, 27 Mar. 2016
      • Allele frequency distribution in PNLIP promotor SNP is different between high-marbled and low-marbled Japanese Black beef cattle.
        Muramatsu Y; Tanomura H; Yamamoto T; Ohta T; Kose H; Yamada T
        Open J. Anim. Sci., 2016
      • Allele frequency distribution of the NCAPG c.1326T>G SNP associated with growth-related traits in Niigata population of Japanese Black beef cattle.
        Tong B; Muramatsu Y; Fuke N; Himizu Y; Katou H; Ohta T; Kose H; Yamada T
        Open J. Anim. Sci., 2016
      • Unilateral nephrectomy and salt supplementation in Spontaneously Diabetic Torii fatty rat expedites renal complications and glomerular filtration rate decline within 10 weeks. Targeting Inflammation and Podocytopathy in Chronic Kidney Disease
        Briand F; Shinohara M; Brousseau E; Miyajima K; Ohta T; Kageyama Y; Sulpice T
        The New York Academy of Sciences, 2016, Peer-reviewed
      • 肥満2型糖尿病モデルSDT fattyラットの糖尿病合併症に対するSGLT阻害薬の効果
        篠原雅巳; 太田毅; 勝田佳朋; 笹瀬智彦; 唯木洋暢; 米良泰子; 本橋雄; 剣持佑介; 豊田薫; 柿本恒知; 久米新一
        日本糖尿病・肥満動物学会年次学術集会プログラム・講演抄録集, 2016
      • Drug therapy in type 2 diabetes (Part 2) - Protein tyrosine phosphatase 1B(PTP1B) inhibitor -
        Ohta T
        ABSTRACT BOOK ICAMBBE2015, Aug. 2015
      • 肥満2型糖尿病モデルSDT fattyラットの糖尿病合併症におけるSGLT阻害薬の効果の検討
        OTA TSUYOSHI; KATSUTA YOSHITOMO; SASASE TOMOHIKO; TADAKI HIRONOBU; MERA YASUKO; MOTOHASHI TAKESHI; KENMOCHI YUSUKE; TOYODA KAORU; KAKIMOTO TSUNETOMO; SHINOHARA MASAMI; KUME SHIN'ICHI
        日本畜産学会大会講演要旨, 28 Mar. 2015
      • 肥満2型糖尿病モデルSDT fattyラットにおける食塩負荷による病態生理学的変化の検討
        篠原雅巳; 太田毅; 勝田佳朋; 剣持佑介; 槇美実; 佐野龍平; 石井幸仁; 美谷島克宏; 柿本恒知
        Japan Society of Experimental Diabetes and Obesity Program & Abstracts, Feb. 2015
      • 肥満2型糖尿病モデル雌性SDT fattyラットに認められたNASH様病変について
        篠原雅巳; 美谷島克宏; 剣持佑介; 勝田佳朋; 石井幸仁; 柿本恒知; 太田毅
        Japan Society of Experimental Diabetes and Obesity Program & Abstracts, Feb. 2015
      • Female SDT-fatty rats show NASH-like hepatic lesions
        Miyajima K; Ohta T; Katsuda Y; Ishii Y; Kakimoto K; Yasui Y; Kemmochi Y; Nakamura/Anagawa A; Toyoda K; Taniai E; Takahashi A; Miyakawa Y; Shoda T
        The 31st Annual Meeting of the Japanese Society of Toxicologic Pathology, Jan. 2015
      • Investigation of gender difference of physiological response in gonadectomy in Sprague-Dawley (SD) rats.
        Miyajima K; Toriniwa Y; Motohashi Y; Ishii Y; Kimura S; Shinohara M; Yamashiro H; Yamada T; Ohta T
        J. Adv. Med. Med. Res., 2015
      • Pathophysiological changes by short-term food restriction in obese diabetic rats.
        Miyajima K; Toriniwa Y; Motohashi Y; Ishii Y; Shinohara M; Yamashiro H; Yamada T; Ohta T
        J. Adv. Med. Med. Res., 2015
      • Effects of isolation stress on glucose/lipid metabolism in Spontaneously Diabetic Torii (SDT) fatty rats.
        Miyajima K; Toriniwa Y; Motohashi Y; Ishii Y; Shinohara M; Yamashiro H; Yamada T; Ohta T
        J. Adv. Med. Med. Res., 2015
      • Effects on fat distribution by food restriction in Zucker diabetic fatty rats.
        Ohta T; Ishii Y; Shinohara M; Yamashiro H; Yamada T
        J. Adv. Med. Med. Res., 2015
      • Diet-induced fatty hepatic steatosis in male Spontaneously Diabetic Torii (SDT) fatty rats, a genetic model for obese type 2 diabetes.
        Ohta T; Motohashi Y; Miyajima K; Kemmochi Y; Ishii Y; Shinohara M; Yamada T
        J. Adv. Med. Med. Res., 2015
      • Drug therapy in type 2 diabetes: glucose sensor activator
        Ohta T
        ABSTRACT BOOK ICAMBBE2014, Sep. 2014
      • 新規肥満2型糖尿病モデルSDT fattyラットにおける食塩負荷による病態生理学的変化の検討
        太田毅; 勝田佳朋; 剣持佑介; 槇美実; 佐野龍平; 石井幸仁; 篠原雅巳; 美谷島克宏; 柿本恒知
        日本畜産学会第118回大会講演要旨, Mar. 2014
      • Salt intake deteriorates kidney lesions in Spontaneously Diabetic Torii-Leprfa (SDT fatty) rats
        Kenmochi Y; Katsuda Y; Maki M; Ohta T; Toyoda K; Miyajima K; Yasui Y; Nakamura A; Taniai E; Takahashi A; Kakimoto K; Miyakawa Y; Shoda T
        The 30th Annual Meeting of the Japanese Society of Toxicologic Pathology Poster Presentation, Jan. 2014
      • Pharmacological effect of α-glucosidase inhibitor voglibose in a novel obese diabetic model.
        Ohta T; Kemmochi Y; Miyajima K; Shinohara M; Yamada T
        J. Pharm. Res. Int., 2014
      • Spontaneously Diabetic Torii (SDT) rat and SDT fatty rat -New Animal Models of Type 2 Diabetes- with Severe Diabetic Complications.
        Shinohara M; Sasase T; Miyajima K; Ohta T
        Asian Symposium on Sciences of Oriental Medicine, 2014
      • Female SDT fatty rat shows Non-Alcoholic Steatohepatitis (NASH)-like hepatic lesions-pathophysiological analysis of liver in female Spontaneously Diabetic Torii fatty rats-.
        Miyajima K; Ohta T; Katsuda Y; Ishii Y; Kakimoto K; Yasui Y; Kemmochi Y; nakamura A; Toyoda K; Taniai E; Takahashi A; Miyakawa Y; Shoda T
        Society of Toxicologic Pathology, 33rd Annual Sympojium, 2014, Peer-reviewed
      • Possible association of single nucleotide polymorphism in the myosin heavy chain 1 gene with growth-related trait in japanese black beef cattle
        Bin Tong; Kaifeng Wu; Seiki Sasaki; Youji Muramatsu; Takeshi Ohta; Hiroyuki Kose; Takahisa Yamada
        Journal of Animal and Veterinary Advances, 2014
      • Association of single nucleotide polymorphism in IRS1 gene with growth-related trait in Japanese black beef cattle
        Yao Wu; Bin Tong; Kaifeng Wu; Seiki Sasaki; Youji Muramatsu; Takeshi Ohta; Hiroyuki Kose; Takahisa Yamada; Dong Zhang; Guoxin Ni
        Journal of Animal and Veterinary Advances, 2014
      • 肥満2型糖尿病モデルSDT fattyラットにおける過食におけるグレリン分泌異常の関与
        田尻祐司; 西芳寛; 原健人; 平田留美子; 太田毅; 笹瀬智彦; 細田洋司; 寒川賢治; 児島将康; 御船弘治; 山田研太郎
        第63回日本体質医学会講演要旨, Oct. 2013
      • 新規肥満糖尿病モデルSDT fattyラットの腎病変に関する検討
        太田毅; 笹瀬智彦; 美谷島克宏; 剣持佑介; 篠原雅巳; Tong Bin; 杉山稔恵; 山田宜永
        日本畜産学会第117回大会講演要旨, Sep. 2013
      • 肥満2型糖尿病モデルSDT fattyラットにおける過食とグレリン分泌動態
        原健人; 田尻祐司; 西芳寛; 副島恵理; 平田留美子; 太田毅; 笹瀬智彦; 山田研太郎; 細田洋司; 寒川賢治; 児島将康; 御船弘治
        第31回内分泌代謝学サマーセミナー講演要旨, Jul. 2013
      • 肥満2型糖尿病モデルSDT fattyラットにおける過食におけるグレリン分泌異常の関与
        田尻祐司; 西芳寛; 原健人; 副島恵理; 平田留美子; 太田毅; 笹瀬智彦; 細田洋司; 寒川賢治; 児島将康; 御船弘治; 山田研太郎
        糖尿病, May 2013
      • VEGFシグナル阻害はSDTラットにおけるβ細胞傷害と糖尿病発症を抑制する
        向英里; 太田毅; 河村治清; 李恩瑛; 森田亜州華; 笹瀬智彦; 稲垣暢也; 岩永敏彦; 三木隆司
        糖尿病, May 2013
      • No replicated association of the c.-312A>G in EDG1 with marbling in Niigata population of Japanese Black beef cattle.
        Tong B; Fuke N; Himizu Y; Katou H; Hatano M; Ohta T; Kose H; Yamada T
        Open J. Anim. Sci., 2013
      • Replicated association of the single nucleotide polymorphism in PNLIP with marbling in Niigata population of Japanese Black beef cattle.
        Tanomura H; Muramatsu Y; Yamamoto T; Ohta T; Kose H; Yamada T
        Open J. Anim. Sci., 2013
      • Inhibition of VEGFR signaling suppresses beta-cell injury and diabetes development in SDT rats
        Eri Mukai; Takeshi Ohta; Harukiyo Kawamura; Tomohiko Sasase; Eun-Young Lee; Asuka Morita; Nobuya Inagaki; Toshihiko Iwanaga; Takashi Miki
        JOURNAL OF PHYSIOLOGICAL SCIENCES, 2013
      • Diabetic mouse models.
        Katsuda Y; Ohta T; Shinohara M; Tong B; Yamada T
        Open J. Anim. Sci., 2013
      • 非肥満2型糖尿病モデルSDTラット
        篠原雅巳; 太田毅; 笹瀬智彦
        第26回日本糖尿病・肥満動物学会講演要旨, Feb. 2012
      • Effect of phlorizin on metabolic abnormalities in Spontaneously Diabetic Torii (SDT) rats.
        Ohta T; Morinaga H; Yamamoto T; Yamada T
        Open J. Anim. Sci., 2012
      • Severely Progressed Diabetes-Associated Renal Complication in the Spontaneously Diabetic Torii (SDT) Fatty Rat at Ages over 50 Weeks – Histopathological Examination -.
        Kemmochi Y; Miyajima K; Yasui Y; Ohta T; Sasase T; Takahashi A; Toyoda K; Masuyama T; Shoda T; Kakimoto K
        Society of Toxicologic Pathology, 31st Annual Symposium, 2012, Peer-reviewed
      • Enhanced VEGF signaling in islets contributes to β-cell injury ans consequential diabetes in SDT rats.
        Mukai E; Ohta T; Kawamura H; Lee E-Y; Morita A; Inagaki N; Iwanaga T; Miki T
        J. Diabetes Investig., 2012, Peer-reviewed
      • Preliminary association study of single nucleotide polymorphism in MYH1 and TRDN genes for growth-related traits in Japanese Black Beef Cattle.
        Wu K; Tong B; Sasaki S; Muramatsu Y; Ohta T; Kose H; Yamashiro H; Yamada T; Zhang Y
        J. Anim. Vet. Adv., 2012
      • Possible effects of single nucleotide polymorphism in CDC10, IRS-1 and MFN2 genes on growth-related traits in Japanese Black Beef Cattle.
        Tong B; Wu K; Sasaki S; Muramatsu Y; Ohta T; Kose H; Yamashiro H; Zhang Y; Yamada T
        J. Anim. Vet. Adv., 2012
      • Useful g.70014208G>A SNP marker in MYBPC1 gene showing marbling-associated expression changes.
        Tong B; Sasaki S; Muramatsu Y; Ohta T; Kose H; Yamashiro H; Yamada T
        J. Anim. Vet. Adv., 2012
      • Polymorphisms in promoter regions of MYH1 and IRS1 genes showing marbling-associated expression changes.
        Tong B; Sasaki S; Muramatsu Y; Ohta T; Kose H; Yamashiro H; Yamada T
        J. Anim. Vet. Adv., 2012
      • Preliminary association study of SNPS in MFN2 gene showing marbling-associated expression changes
        Bin Tong; Youji Muramatsu; Takuji Yamamoto; Hideki Tanomura; Takeshi Ohta; Hiroyuki Kose; Toshie Sugiyama; Takahisa Yamada
        Journal of Animal and Veterinary Advances, 2012
      • Useful marker around TRDN gene showing marbling-associated expression changes
        Bin Tong; Youji Muramatsu; Takuji Yamamoto; Hideki Tanomura; Takeshi Ohta; Hiroyuki Kose; Toshie Sugiyama; Takahisa Yamada
        Journal of Animal and Veterinary Advances, 2012
      • Polymorphism in promoter region of CDC10 gene showing marbling-associated expression changes
        Bin Tong; Youji Muramatsu; Takuji Yamamoto; Hideki Tanomura; Takeshi Ohta; Hiroyuki Kose; Toshie Sugiyama; Takahisa Yamada
        Journal of Animal and Veterinary Advances, 2012
      • Distribution of allele frequency at PNLIP rs41648172 between Japanese Black and four other cattle breeds with differing historical selection for marbling
        Hideki Tanomura; Youji Muramatsu; Takuji Yamamoto; Takeshi Ohta; Hiroyuki Kose; Takahisa Yamada
        Journal of Animal and Veterinary Advances, 2012
      • Association of single nucleotide polymorphism in pancreatic lipase gene with growth-related traits in Japanese Black beef cattle
        Hideki Tanomura; Youji Muramatsu; Takuji Yamamoto; Takeshi Ohta; Hiroyuki Kose; Takahisa Yamada
        Journal of Animal and Veterinary Advances, 2012
      • Inhibition of postprandial hyperglycemia prevents the incidence of diabetes in spontaneously diabetic torn (SDT) rats
        Takeshi Ohta; Katsuhiro Miyajima; Masami Shinohara; Takuji Yamamoto; Takahisa Yamada
        Journal of Animal and Veterinary Advances, 2012, Lead author
      • Pancreatic abnormalities at a young age in Spontaneously Diabetic Torii (SDT) rats
        Takeshi Ohta; Masami Shinohara; Takuji Yamamoto; Takahisa Yamada
        Journal of Animal and Veterinary Advances, 2012, Lead author
      • Change in protein tyrosine phosphatase activity in spontaneous diabetic Torii(SDT) rats
        Yamaguchi,T; Ohta,T; Morinaga,H; Hata,T; Sato,E; Matsushita,M
        Open J.Anim.Sci., 2012
      • 肥満2型糖尿病モデルSDT fattyラットにおける骨障害
        木村修一; 笹瀬智彦; 太田毅; 松下睦佳
        第26回日本糖尿病合併症学会プログラム・抄録集, Oct. 2011
      • Spontaneously Diabetic Torii (SDT) fattyラットにおける自然発生性ぶどう膜炎について:病理組織学的検討
        剣持佑介; 美谷島克宏; 安井雄三; 益山拓; 太田毅; 笹瀬智彦; 柿本恒知
        第26回日本糖尿病合併症学会プログラム・抄録集, Oct. 2011
      • 非肥満2型糖尿病モデルSDTラット
        篠原雅巳; 太田毅; 笹瀬智彦
        第25回日本糖尿病・肥満動物学会講演要旨追加発言, Mar. 2011
      • Difference in pnlip allele frequency distribution between high-marbled and low-marbled cattle
        Hideki Tanomura; Youji Muramatsu; Takuji Yamamoto; Takeshi Ohta; Hiroyuki Kose; Takahisa Yamada
        Journal of Animal and Veterinary Advances, 2011
      • The Pancreatic lipase gene is associated with marbling in Japanese Black beef cattle
        Hideki Tanomura; Takuji Yamamoto; Youji Muramatsu; Takeshi Ohta; Hiroyuki Kose; Takahisa Yamada
        Journal of Animal and Veterinary Advances, 2011
      • Quantitative trait gene responsible for intramuscular fat content in the rat
        Hideki Tanomura; Takuji Yamamoto; Youji Muramatsu; Takeshi Ohta; Takahisa Yamada
        Journal of Animal and Veterinary Advances, 2011
      • Pathophysiological changes in pre-diabetic stage of Spontaneously Diabetic Torii (SDT) rats
        Takeshi Ohta; Katsuhiro Miyajima; Takahisa Yamada
        Journal of Animal and Veterinary Advances, 2011, Lead author
      • Diabetic neuropathy in spontaneously diabetic Torii rat
        Tomohiko Sasase; Takeshi Ohta
        Open Diabetes Journal, 2011
      • Glucose and lipid metabolism in spontaneously diabetic Torii rat
        Yasuko Mera; Hisayo Morinaga; Takeshi Ohta; Tomohiko Sasase
        Open Diabetes Journal, 2011
      • Spontaneously diabetic Torii Leprfa (SDT fatty) rat: A novel model of obese type 2 diabetes
        Sumiaki Fukuda; Katsuhiro Miyajima; Tomohiko Sasase; Takeshi Ohta
        Open Diabetes Journal, 2011
      • Diabetic nephropathy in spontaneously diabetic Torii (SDT) rats
        Takeshi Ohta; Tomohiko Sasase
        Open Diabetes Journal, 2011
      • The SDT rat: A new animal model of non-obese type 2 diabetes with diabetic complications.
        Shinohara M; Masuyama T; Ohta T; Sasase T; Yokoi N; Kakehashi A
        The XVIIIth international workshop on genetic systems in the rat, 2010
      • Pancreatic weakness in Zucker Fatty rats, a genetic obese model
        Takeshi Ohta; Katsuhiro Miyajima; Takahisa Yamada
        Journal of Animal and Veterinary Advances, 2010, Lead author
      • Changes in glycolipid metabolism during a high-sucrose feeding hi Spontaneously Diabetic Torii (SDT) rats, a genetic model of nonobese type 2 diabetes
        Takeshi Ohta; Katsuhiro Miyajima; Takahisa Yamada
        Journal of Animal and Veterinary Advances, 2010, Lead author
      • 肥満2型糖尿病モデルSDT fattyラットの膵臓に制限給餌が及ぼす影響
        石井幸仁; 太田毅; 笹瀬智彦; 森長寿代; 上田正俊; 美谷島克宏; 角谷真
        第23回日本糖尿病・肥満動物学会講演要旨, Feb. 2009
      • Effects of preventing hyperphagia on glycolipid metabolic abnormalities in Spontaneously Diabetic Torii fatty rats (vol 79, pg 605, 2008)
        Kenichi Matsui; Takeshi Ohta; Hisayo Morinaga; Tomohiko Sasase; Sumiaki Fukuda; Makoto Ito; Masatoshi Ueda; Naoto Ogawa; Katsuhiro Miyajima; Mutsuyoshi Matsushita
        ANIMAL SCIENCE JOURNAL, Dec. 2008
      • 新規肥満2型糖尿病モデルSDT fattyラットの病態に摂餌制限が及ぼす影響
        石井幸仁; 太田毅; 松井謙一; 森長寿代; 笹瀬智彦; 福田純明; 伊藤誠; 上田正俊; 美谷島克宏; 松下睦佳
        第22回日本糖尿病・肥満動物学会講演要旨, Feb. 2008
      • PKC beta inhibitor prevents early diabetic complications, but does not prevent histopathological abnormalities of retina in spontaneously diabetic Torii rat
        Tomohiko Sasase; Hisayo Morinaga; Katsuhiro Miyajima; Taku Masuyama; Takeshi Ohta; Mutsuyoshi Matsushita; Fumihiko Yonemori; Masami Shinohara; Akihiro Kakehashi; Yasunori Kanazawa
        DIABETES, Jun. 2007, Peer-reviewed
      • SDTラットの糖尿病合併症に対するPKCβ阻害剤の作用
        笹瀬智彦; 森長寿代; 益山拓; 美谷島克宏; 太田毅; 松下睦佳; 篠原雅巳; 梯彰弘; 金澤康徳
        第4回SDTラット研究会講演要旨, Dec. 2006
      • Spontaneously Diabetic Torii (SDT) fattyラットの脂質代謝に関する基礎的研究
        笹瀬智彦; 山本裕美; 森長寿代; 小川直人; 河合孝; 米良泰子; 美谷島克宏; 益山拓; 篠原雅巳; 太田毅; 角谷真; 松下睦佳
        Exp.Anim., May 2006
      • Spontaneously Diabetic Torii (SDT) fattyラットの脂質吸収と食後高TG血症に関する基礎的検討
        笹瀬智彦; 山本裕美; 森長寿代; 小川直人; 河合孝; 米良泰子; 美谷島克宏; 益山拓; 篠原雅巳; 太田毅; 角谷真; 松下睦佳
        J.Pharm.Sci., Mar. 2006
      • SDT fattyラットの糖尿病態に関する基礎的検討
        太田毅; 上田順久; 小田知洋; 森長寿代; 伊藤誠; 福田純明; 小川直人; 美谷島克宏; 笹瀬智彦; 松下睦佳
        第4回SDTラット研究会講演要旨, 2006
      • Fat absorption and postprandial hypertriglyceridemia of Spontaneously Diabetic Torii (SDT) rat
        T Sasase; H Yamamoto; H Morinaga; N Ogawa; T Kawai; Y Mera; KN Ima; T Ohta; M Kakutani; M Matsushita
        JOURNAL OF PHARMACOLOGICAL SCIENCES, 2006
      • SDTラットの脂質代謝に関する基礎的検討
        小川直人; 笹瀬智彦; 山本裕美; 森長寿代; 河合孝; 米良泰子; 美谷島克宏; 太田毅; 角谷真; 松下睦佳
        第3回SDTラット研究会講演要旨, 2005
      • SDTラットの単離膵ラ氏島を用いたインスリン分泌能の検討
        松井謙一; 小田知洋; 山本裕美; 福田純明; 笹瀬智彦; 美谷島克宏; 太田毅; 松下睦佳
        第3回SDTラット研究会講演要旨, 2005
      • 血糖コントロールによるSpontaneously Diabetic Torii (SDT)ラットの眼病変改善
        笹瀬智彦; 太田毅; 小川直人; 美谷島克宏; 松下睦佳
        日本薬理学部会(日本薬理学会雑誌), 2005
      • Diabetic complications of spontaneously diabetic Torii rat
        T Sasase; T Ohta; N Ogawa; K Miyajima; H Koizumi; M Matsushita; Y Kanazawa
        DIABETES, 2005, Peer-reviewed
      • SDTラット肝臓の糖代謝に関する検討
        森長寿代; 山本裕美; 笹瀬智彦; 美谷島克宏; 太田毅; 松下睦佳
        第2回SDTラット研究会講演要旨, 2004
      • SDTラットにおける腎臓病変の経時的変化について
        美谷島克宏; 太田毅; 笹瀬智彦; 松下睦佳; 益山拓; 岩坂俊基; 小泉治子
        第2回SDTラット研究会講演要旨, 2004
      • 血糖コントロールによるSpontaneously Diabetic Torii (SDT) fattyラットの眼病変改善
        笹瀬智彦; 太田毅; 小川直人; 美谷島克宏; 松下睦佳
        第19回日本糖尿病合併症学会プログラム・抄録集, 2004
      • インスリン治療によるSpontaneously Diabetic Torii (SDT) fattyラットの眼病変改善
        笹瀬智彦; 太田毅; 小川直人; 美谷島克宏; 松下睦佳
        第111回薬理学会関東部会講演要旨, 2004
      • Protein-tyrosine phosphatase 1B as new activator for hepatic lipogenesis via sterol regulatory element-binding protein-1 gene expression.
        Maegawa H; Shimizu S; Ugi S; Yoshizaki T; Egawa K; Nishio Y; Ohta T; Iwasaka T; Bryer-ash M; Kashiwagi A
        DIABETES, Jun. 2003, Peer-reviewed
      • SDTラットの糖尿病網膜症モデルとしての有用性
        笹瀬智彦; 小川直人; 太田毅; 松下睦佳
        第1回SDTラット研究会講演要旨, 2003
      • 新規糖尿病治療薬JTT-608はphosphodesterase活性を抑制して膵ラ氏島からのインスリン分泌を促進する
        向英里; 石田均; 藤本新平; 古川昇; 太田毅; 梶川麻里子; 岡本吉将; 藤田準; 津浦佳之; 清野裕
        糖尿病, 1999
      • The insulinotropic mechanism of the novel hypoglycemic agent, JTT-608: Direct enhancement of Ca2+ efficacy with increase of Ca2+ influx by phosphodiesterase inhibition
        E Mukai; H Ishida; S Fujimoto; N Furukawa; T Ohta; Y Yamada; Y Seino
        DIABETES, 1999, Peer-reviewed
      • The effects of a γ-ketocarbonic acid derivative on GLP-1 and insulin secretion in rat.
        Manaka H; Ohnuma H; Ohta T; Eguchi H; Yamaguchi H; Kimura M; Daimon M; Yamantani K; Kato T; Sasaki H
        DIABETES, Jun. 1998, Peer-reviewed
      • GLP-1分泌に及ぼすJTT608の効果
        間中英夫; 太田毅; 大沼寛; 木村守; 山口宏; 江口英行; 大門真; 山谷恵一; 佐々木英夫; 加藤丈夫
        糖尿病, 1998
      • 新規糖尿病治療薬JTT-608の膵ラ氏島に対するインスリン分泌促進効果とその作用機序
        向英里; 石田均; 藤本新平; 古川昇; 太田毅; 津浦佳之; 西村正仁; 水野展寿; 梶川麻里子; 清野裕
        糖尿病, 1998
      • 新生仔期マウスへのビタミンA補給の腸管および脾臓に対する影響の検討
        水永武寿; 仲野彰紘; 太田毅; 杉本実紀
        KANSAI JOURNAL OF ANIMAL SCIENCE, Mar. 2022
      • ウシ胎盤のヒストンH3K4me3修飾の全ゲノムプロファイル
        服部佳乃子; 池田俊太郎; 江頭海; 可知正行; 増田康充; 星野洋一郎; 太田毅; 南直治郎
        KANSAI JOURNAL OF ANIMAL SCIENCE, Mar. 2022

      Presentations

      • 高ショ糖/高脂肪/高コレステロール食給餌が肥満2型糖尿病モデルマウスdb/dbマウス、およびKK-Ayマウスの肝臓に及ぼす影響
        白坂航大; 武呂大和; 筒井誉大; 小郷智記; 宇野絹子; 万代康平; 杉本実紀; 笹瀬智彦; 篠原雅巳; 美谷島克宏; 太田毅
        日本畜産学会第130回大会, 16 Sep. 2022
      • Pathological analysis of kidney and comparison of male and female SDT fatty rats, an obese model of type 2 diabetes mellitus, fed a high sucrose and high fat diet
        Watanabe K; Miyajima K; Mandai K; Sekiguti K; Kemuriyama N; Sasase T; Watanabe T; Ito H; Shinohara M; Ohta T
        The 4th International Seminar on Smart Molecule of Natural Resources (ISSMART) - Asian Federation of Biotechnology (AFOB) 2022, 25 Aug. 2022
      • Pathological analysis of the kidney of obese type 2 diabetic model SDT fatty rats fed high-sucrose/high-fat diet and comparison between males and females
        Watanabe K; Miyajima K; Mandai K; Sekiguchi K; Uno K; Kemuriyama N; Sasase T; Watanabe T; Ito H; Shinohara M; Nakae D; Ohta T
        The 49th annual meeting of the Japanese society of toxicology, 30 Jun. 2022
      • SDT fatty rat 糖尿病網膜症に対するペマフィブラートの効果
        田中克明; 高木理那; 御任真言; 榛村真智子; 長谷川哲也; 染谷省吾; 篠原雅巳; 影山靖; 笹瀬智彦; 太田毅; 村松慎一; 梯彰弘; 蕪城俊克
        The 126th Annual Meeting of the Japanese Ophthalmological Society, 14 Apr. 2022
      • 2型糖尿病モデル動物の病態におけるグルカゴンの関与
        万代康平; 美谷島克宏; 渡邊果奈; 石塚佳菜; 宇野絹子; 煙山紀子; 笹瀬智彦; 渡辺寿久; 伊藤秀樹; 篠原雅巳; 太田毅; 中江大
        第38回日本毒性病理学会, 26 Jan. 2022
      • 糖尿病モデル動物を用いたACE2発現によるCOVID-19重症化モデルとしての検討
        畑中悠里; 美谷島克宏; 宇野絹子; 当摩茉莉花; グエンハン二ユン; 煙山紀子; 渡辺寿久; 伊藤秀樹; 篠原雅巳; 笹瀬智彦; 太田毅; 中江大
        第38回日本毒性病理学会, 26 Jan. 2022
      • 肥満2型糖尿病モデルSDT fatty ラットの糖尿病性腎臓病早期におけるダパグリフロジンの腎保護効果の検討
        篠原雅巳; 黒木楓子; 杉本実紀; 佐野龍平; 美谷島克宏; 中江大; 太田毅
        第32回日本糖尿病性腎症研究会, 05 Dec. 2021
      • 高ショ糖/高脂肪食給餌が肥満2型糖尿病モデルマウスdb/dbマウスおよびKK-Ayマウスの腎臓に及ぼす影響
        筒井誉大; 万代康平; 宇野絹子; 関口敬大; 白坂航大; 武呂大和; 杉本実紀; 篠原雅巳; 美谷島克宏; 笹瀬智彦; 太田毅
        第32回日本糖尿病性腎症研究会, 04 Dec. 2021
      • 高ショ糖/高脂肪食給餌が肥満2型糖尿病モデルSDT fattyラットの腎臓に及ぼす影響について
        渡邉果奈; 美谷島克宏; 万代康平; 宇野絹子; 関口敬大; 煙山紀子; 笹瀬智彦; 渡辺寿久; 伊藤秀樹; 篠原雅巳; 中江大; 太田毅
        第30回日本健康医学会, 13 Nov. 2021
      • 2型糖尿病モデル動物におけるサルコペニアの病態解析
        太田毅; 篠原雅巳; 剣持佑介; 前川竜也; 万代康平; 石塚佳菜; 美谷島克宏; 山田宜永
        第36回日本糖尿病合併症学会, 09 Oct. 2021
      • 新生仔期マウスへのビタミンA補給の腸管および脾臓に対する影響の検討
        水永武寿; 仲野彰紘; 太田毅; 杉本実紀
        第71回関西畜産学会神戸大会, 02 Oct. 2021
      • ウシ胎盤のヒストンH3K4me3修飾の全ゲノムプロファイル
        服部佳乃; 池田俊太郎; 江頭海; 可知正行; 増田康充; 星野洋一郎; 太田毅; 南直治郎
        第71回関西畜産学会神戸大会, 02 Oct. 2021
      • 肥満2型糖尿病モデルマウスの空腸における病態生理学的解析
        西田芽衣; 黒木楓子; 小郷智記; 笹瀬智彦; 杉本実紀; 宇野絹子; 美谷島克宏; 太田毅
        日本畜産学会第129回大会, 15 Sep. 2021
      • The relationship pf plasma cholesterol and atherosclerotic lesions in congenic spontaneously hyperlipidemic mice
        Tadaki H; Sasase T; Maekawa T; Yamada T; Ohta T
        The 3rd International Seminar on Smart Molecule of Natural Resources (ISSMART) - Asian Federation of Biotechnology (AFOB), 26 Aug. 2021
      • Brain abnormalities in Spontaneously Diabetic Torii-Leprfa (SDT fatty) rats
        Maekawa T; Sasase T; Shinohara M; Kume S; Ohta T
        The 3rd International Seminar on Smart Molecule of Natural Resources (ISSMART) - Asian Federation of Biotechnology (AFOB), 25 Aug. 2021
      • Analysis of ACE2 expression in SDT fatty rats
        Uno K; Miyajima K; Ishida Y; Yamaguchi A; Mandai K; Uechi T; Kemuriyama N; Shinohara M; Sasase T; Ohta T; Nakae D
        第48回日本毒性学会, 07 Jul. 2021
      • Effect of high fat diet on liver in db/db and KK-Ay mice
        Mandai K; Miyajima K; Kitamura S; Yamaguchi A; Uno K; Kuroki F; Nishida M; Shirasaka K; Tsutsui Y; Muro Y; Sugimoto M; Kemuriyama N; Shinohara M; Sasase T; Ohta T; Nakae D
        第48回日本毒性学会, 07 Jul. 2021
      • Regulation of fatty acid biosynthesis in liver through GPR52 signaling
        Wada M; Yukawa K; Ogasawara H; Suzawa K; Maekawa T; Yamamoto Y; Ohta T; Lee EY; Miki T
        第98回日本生理学会, 30 Mar. 2021
      • Unmet Medical Needsを意識したモデル動物のキャラクタリゼーション
        太田 毅
        第145回関西実験動物研究会, 05 Mar. 2021, Invited
      • 肥満2型糖尿病モデルSDT fattyラットにおける糖尿病性腎症初期病変の検討
        黒木楓子; 杉本実紀; 佐野龍平; 美谷島克宏; 中江大; 篠原雅巳; 太田毅
        第70回関西畜産学会, 04 Oct. 2020
      • 肥満2型糖尿病動物の末梢血管障害に関する検討
        太田毅; 村井康高; 篠原雅巳; 山田宜永
        第70回関西畜産学会, 04 Oct. 2020
      • ウシ桑実胚でのヒストンメチル化プロファイリングおよびMAT2Aの寄与の解析
        太田愛理; 池田俊太郎; 篠澤章久; 岩田尚孝; 杉本実紀; 久米新一; 南直治郎; 太田毅
        第70回関西畜産学会, 04 Oct. 2020
      • 新生仔期マウスへのビタミンA補給による腸管、胸腺、脾臓の発育に対する影響の検討
        仲野彰紘; 水永武寿; 太田毅; 杉本実紀
        第70回関西畜産学会, 03 Oct. 2020
      • ウシ初期胚におけるヒストンメチル化修飾への外因性メチオニンの関与
        太田愛理; 池田俊太郎; 杉本実紀; 南直治郎; 太田毅
        第113回日本繁殖生物学会, 25 Sep. 2020
      • Experimental animals and Drug discovery research
        Takeshi Ohta
        Faculty of Mathematic and Natural Science, Brawijaya University, Sep. 2020, Invited
      • Glucose sensing insulin secretion with hyperglycemia clamp technique in Sprague Dawley rats
        Tadaki H; Sasase T; Toriniwa Y; Yamada T; Ohta T
        Online International Seminar The 2nd International Seminar on Smart Molecule of Natural Resources (ISSMART) 2020, 25 Aug. 2020
      • Hemodynamics in the obese type 2 diabetes model Spontaneously Diabetic Torii Leprfa (SDT fatty) rats
        Sasase T; Murai Y; Shinohara M; Yamada T; Ohta T
        Online International Seminar The 2nd International Seminar on Smart Molecule of Natural Resources (ISSMART) 2020, 25 Aug. 2020
      • 糖尿病モデル動物であるSDT fattyラットにおけるCDAA食ならびにHF食の肝臓及び 脂肪組織に及ぼす影響
        万代 康平; 美谷島 克宏; 山口 彩音; 山本 敦也; 町田 七海; 森田 茉穂; 岩本 健志郎; 煙山 紀; 篠原 雅巳; 太田 毅; 中江 大
        The 47th Annual Meeting of the Japanese Society of Toxicology, Jun. 2020
      • 2型糖尿病モデルdb/dbおよびKK-Ayマウスの腎臓における高脂肪食摂餌の影響
        山口 彩音; 美谷島 克宏; 宇野 絹子; 杉本 実紀; 黒木 楓子; 西田 芽衣; 小郷 智記; 煙山 紀子; 篠原 雅巳; 中江 大; 太田 毅
        The 47th Annual Meeting of the Japanese Society of Toxicology, Jun. 2020
      • 動物モデルの最適化 ー 病態の特徴把握と発症早期化に向けて ー
        太田 毅
        第67回日本実験動物学会ランチョンセミナー(誌上発表), May 2020, Invited
      • メチレンテトラヒドロ還元酵素(MTHFR)の胚盤胞発生の寄与について
        石谷洋希; 池田俊太郎; 杉本実紀; 南直治郎; 太田毅
        第8回関西生殖医学集会, 29 Feb. 2020
      • SDT fattyラットにおける片腎摘出術および食塩負荷が糖尿病網膜症進展に及ぼす影響
        篠原雅巳; Francois Briand; Sophie Antoneli; Virginie Mauro; Nicolas Cimbolini; Emmanuel Brousseau; 太田毅; 美谷島克宏; 影山靖; Laurence Feraille; Thierry Sulpice
        第36回日本毒性病理学会, 14 Feb. 2020
      • SDT fattyラットの死亡動物における腎臓および心臓の病理組織学的変化
        山口彩音; 美谷島克宏; 橋本杏奈; 煙山紀子; 篠原雅己; 太田毅; 中江大
        第36回日本毒性病理学会, 13 Feb. 2020
      • SDT fatty ラットに認められた糖尿病・肥満サルコペニアについて
        篠原雅巳、剣持佑介、太田毅、山田宜永
        第34回 日本糖尿病・肥満動物学会, 01 Feb. 2020
      • DapagliflozinあるいはDapagliflozinとRamiprilの併用投与が糖尿病モデルSDT fattyラットの腎症に及ぼす影響
        太田毅; Francois Briand; 篠原雅巳; 笹瀬智彦; Emmanuel Brousseau; 影山靖; Thierry Sulpice
        第31回日本糖尿病性腎症研究会, Dec. 2019
      • 肥満2型糖尿病モデルSDT fattyラットの腎臓におけるSGLT2の発現および病態の解析
        篠原雅巳; 張舜恵; 宇野絹子; 山口彩音; 太田毅; 美谷島克宏
        第31回日本糖尿病性腎症研究会, Dec. 2019
      • 糖尿病モデル動物におけるコレステロール負荷によるNASH様病変増悪化の検討
        太田毅; 鳥庭靖文; 美谷島克宏; 篠原雅巳; 山田宜永
        第68回北信越畜産学会, Oct. 2019
      • 肥満2型糖尿病モデル動物の骨格筋における病態生理学的変化の検討
        太田毅; 剣持佑介; 篠原雅巳; 山田宜永
        第69回関西畜産学会, Sep. 2019
      • 肥満2型糖尿病モデルSDT fatty ラットにおけるDapaglitazon単剤およびRamiprilとの併用投与による腎症改善効果の検討
        太田毅; Francois Briand; 篠原雅巳; 笹瀬智彦; Emmanuel Brousseau; 影山靖; Thierry Sulpice
        第34回日本糖尿病合併症学会, Sep. 2019
      • 肥満2型糖尿病モデルSDT fattyラットにおける糖尿病黄斑浮腫様変化の病態生理学的解析
        太田 毅; 本橋 雄; 笹瀬 智彦; 剣持 佑介; 前川 竜也; 唯木 洋暢; 田中 克明; 梯 彰弘; 篠原 雅巳; 山田 宜永
        日本畜産学会第126回大会, Sep. 2019
      • ウシ初期胚のヒストンメチル化におけるメチオニンアデノシルトランスフェラーゼの役割
        太田愛里; 池田俊太郎; 杉本実紀; 南直治郎; 太田毅
        第112回日本繁殖生物学会, Sep. 2019
      • TNF-α converting enzyme (TACE) inhibitor: a new approach to prevent development of diabetes
        Sasase T; Maekawa M; Tadaki H; Tomimoto D; Okuma C; Sano R; Ishii Y; Katsuda Y; Yoshiuchi H; Kakefuda R; Ohta T
        6th International Conference on Advanced Molecular Bioscience and Biomedical Engineering (ICAMBBE), Aug. 2019
      • 肥満2型糖尿病モデル雌性SDT fattyラットにおける加齢に伴う腎病変の変化
        篠原雅巳; Teoh Soon Hui; 美谷島克宏; 太田毅; 中江大
        19th Scientific Meeting of the Japanese Society of Anti-Aging Medicine, Jun. 2019
      • Age-related anatomical changes in the cornea of spontaneous type 2 diabetes model rats
        himmura-Tomita M; Takano H; Kinoshita N; Tanaka Y; Takagi R; Kobayashi M; Ohta T; Sasase T; Shinohara M; Kakehashi A
        Arvo 2019, May 2019
      • Pathological features of diabetic retinopathy in unilaterally nephrectomized Spontaneously diabetic Torii fatty rats given 0.3% salt water
        Tanaka Y; Takagi R; Shimmura-Tomita M; Yamaguchi F; Katayama Y; Suzuki T; Shinohara M; Ohta T; Sasase T; Kakehashi A
        ARVO 2019, Apr. 2019
      • 片腎摘出・0.3%食塩負荷SDT fattyラットに発症する糖尿病網膜症の免疫組織化学的検討
        田中克明; 高木理那; 榛村真知子; 山口史成; 片山裕子; 鈴木智久; 篠原雅巳; 太田毅; 笹瀬智彦; 梯彰弘
        123rd Japanese Ophthalmological Society, Apr. 2019
      • TNF-α converting enzyme (TACE) inhibitor prevents insulin resistance and diabetic peripheral neuropathy.
        Maekawa T; Tadaki H; Tomimoto D; Okuma C; Katsuda Y; Ohta T; Sasase T
        92nd The Japanese Pharmacological Society, Mar. 2019
      • SDT fattyラットにおける片腎摘出術および食塩負荷が糖尿病網膜症進展に及ぼす影響について
        篠原雅巳; Briand F; Antonelli S; Mauro V; Cimbolini N; Shinohara M; Brousseau E; 太田毅; 影山靖; Feraille L; Sulpice T
        33rd Japan Society of Experimental Diabetes and Obesity, Mar. 2019
      • 雄SDT fattyラットにおけるSGLT2の発現及び病態解析
        Teoh Soon Hui; 美谷島克宏; 中村優佳; 太田毅; 篠原雅巳; 宇野絹子; 煙山紀子; 中江大
        35th Japanese Society of Toxicologic Pathology, Jan. 2019
      • 雌性SDT fattyラットの非アルコール性脂肪肝炎(NASH)様病態の形成過程における血中パラメータの変動
        龍完治朗; 美谷島克宏; Teoh Soon Hui; 篠原雅巳; 太田毅; 大畑敬一; 宇野絹子; 煙山紀子; 小川英治; 渡邉厚; 中江大
        35th Japanese Society of Toxicologic Pathology, Jan. 2019
      • 食塩負荷が肥満2型糖尿病モデルSDT fattyラットの腎症進展に及ぼす影響
        篠原雅巳; 美谷島克宏; 太田毅; 岩崎日向子; 張舜恵; 宇野絹子; 煙山紀子; 中江大
        30th Japan Diabetic Nephropathy Study, Dec. 2018
      • 食と関連する代謝性疾患に関する創薬研究
        Takeshi Ohta
        東京農業大学応用生物科学部「食品安全健康学概論」, Nov. 2018, Invited
      • 肥満2型糖尿病モデルSDT fattyラットにおける末梢神経障害の検討
        篠原雅巳; 太田毅; 前川竜也; 唯木洋暢; 笹瀬智彦; 本橋雄; 美谷島克宏; 久米新一
        33rd The Japan Society of Diabetic Complications, Oct. 2018
      • Pharmacological responses to anti-diabetic drugs in female SDT fatty rats, a new obese type 2 diabetic rat,
        Ohta T
        5th International Conference on Advance Molecular Bioscience and Biomedical Engineering (ICAMBBE2018), Sep. 2018, Invited
      • Drug therapy in type 2 diabetes and obesity – Monoacylglycerol acyltransferase (MGAT) inhibitor –,
        Ohta T
        4th International Conference on Advance Molecular Bioscience and Biomedical Engineering (ICAMBBE2017), Sep. 2018, Invited
      • Pathophysiological evaluation of the liver in Western diets insulin resistant Zucker fatty rats.
        Maekawa M; Sasase T; Saito T; Toriniwa Y; Ishii Y; Uemura A; Miyajima K; Uno K; Shirai Y; Nakae D; Ohta T
        5th ICAMBBE, Sep. 2018
      • Pathophysiological changes in salt loaded female Spontaneously Diabetic Torii (SDT) fatty rats.
        Teoh SH; Miyajima K; Shinohara M; Briand F; Nakae D; Ohta T
        5th ICAMBBE, Sep. 2018
      • 食生活と関連する代謝性疾患とその治療 -糖尿病・肥満症-
        Takeshi Ohta
        東京農業大学応用生物科学部「一般毒性学」, Jul. 2018, Invited
      • Diabetes and its complications
        Ohta T; Fatchiyah
        Niigata University summer seminar 2018, Jul. 2018, Invited
      • Effects of the loading of excessive sodium chloride on the pathosis mimicking type 2 diabetes mellitus in spontaneously diabetic torii (SDT) fatty rats.
        Teoh SH; Miyajima K; Ohta T; Nakae D
        Global Meeting on Diabetes and Endocrinology 2018, Jul. 2018
      • 雌性SDT fattyラットにおける非アルコール性脂肪肝炎(NASH)様病態の形成における血中バイオマーカーの変動
        龍完治朗; 美谷島克宏; Teoh Soon Hui; 篠原雅巳; 太田毅; 大畑敬一; 宇野絹子; 煙山紀子; 小川英治; 渡邉厚; 中江大
        45th The Japanese Society of Toxicology, Jul. 2018
      • Zucker fatty/leanラットにおけるウエスタンダイエットによる非アルコール性脂肪肝炎(NASH)様病態の誘発
        宇野絹子; 美谷島克宏; 太田毅; 斉藤友幸; 鳥庭靖文; Teoh Soon Hui; 白井雄大; 小川英治; 渡邉厚; 煙山紀子; 中江大
        45th The Japanese Society of Toxicology, Jul. 2018
      • Corneal inflammation in a spontaneous type 2 diabetes model rat.
        Shimmura-Tomita M; Takano H; Kinoshita N; Toyoda F; Tanaka Y; Uehara S; Takagi R; Kobayashi M; Ohta T; Sasase T; Kakehashi A
        ARVO Annual Meeting 2018, May 2018
      • Pathological Features of Diabetic Retinopathy in Spontaneously Diabetic Torii Fatty Rats.
        Tanaka Y; Kobayashi M; Takagi R; Uehara S; Toyoda F; Shimmura-Tomita M; Kinoshita N; Takano H; Ohta T; Sasase T; Kakehashi A
        ARVO Annual Meeting 2018, May 2018
      • The uni-nephrectomized SDT fatty rat, a novel type 2 diabetic model of diabetic nephropathy, develops features of diabetic retinopathy over 10 weeks.
        Briand F; Antonelli S; Mauro V; Cimbolini N; Shinohara M; Brousseau E; Ohta T; Kageyama Y; Feraille L; Sulpice T
        ARVO Annual Meeting 2018, May 2018
      • 雌性SDT fattyラットにおける非アルコール性脂肪肝炎(NASH)様病態の形成段階における血中バイオマーカーの変動
        龍完治朗; 美谷島克宏; Teoh Soon Hui; 篠原雅巳; 太田毅; 大畑敬一; 宇野絹子; 煙山紀子; 小川英治; 渡邉厚; 中江大
        24th Japanese Society of Food Chemistry, May 2018
      • Zucker fattyラットにおいてウエスタンダイエットが非アルコール性脂肪肝炎(NASH)様病態の誘発に及ぼす影響
        宇野絹子; 美谷島克宏; 太田毅; 斉藤友幸; 鳥庭靖文; Teoh Soon Hui; 白井雄大; 小川英治; 渡邉厚; 煙山紀子; 中江大
        24th Japanese Society of Food Chemistry, May 2018
      • SDT fattyラット腎臓の病態生理学的変化
        Takeshi Ohta
        日本クレア㈱石部生育場セミナー, May 2018
      • Experimental animals – The role in development of medicinal drugs-
        Takeshi Ohta
        国際基督教大学教養学部「生命科学A」, Apr. 2018, Invited
      • SDT fattyラットに発症する糖尿病網膜症の免疫組織化学的検討
        田中克明; 小林未奈; 高木理那; 上原志保; 豊田文彦; 榛村真知子; 木下望; 高野博子; 太田毅; 笹瀬智彦; 梯彰弘
        122nd Japanese Ophthalmological Society, Apr. 2018
      • 自然発症2型糖尿病モデルラットにおける角膜炎症
        榛村真智子; 高野博子; 木下望; 豊田文彦; 田中克明; 上原志保; 高木理那; 小林未奈; 太田毅; 笹瀬智彦; 梯彰弘
        122nd Japanese Ophthalmological Society, Apr. 2018
      • Involvement of Glucotoxicity on Peripheral Neuropathy in SDT Fatty Rats, A New Animal Model of Obese Type 2 Diabetes
        Maekawa T; Tadaki H; Sasase T; Motohashi Y; Miyajima K; Ohta T; Kume S, Sponser; E Spicer
        Society of Toxicology 57th Annual Meeting and ToxExpo, Mar. 2018
      • 肥満2型糖尿病モデルSDT fattyラットの末梢神経障害に関する検討
        太田毅; 前川竜也; 唯木洋暢; 笹瀬智彦; 本橋雄; 美谷島克宏; 久米新一
        124th Japanese Society of Animal Science, Mar. 2018
      • Dapagliflozin alone or combination with ramipril improves hyperglycemia, hypertension, and prevents kidney complications and GFR decline in the nephrectomized SDT fatty rat model of diabetic nephropathy.
        Briand F; Shinohara M; Brousseau E; Ohta T; Kageyama Y; Sulpice T
        ISN Frontiers Meetings 2018, Feb. 2018
      • 糖尿病と糖尿病合併症
        Takeshi Ohta
        日本クレア㈱石部生育場セミナー, Feb. 2018
      • 食塩負荷が肥満2型糖尿病モデルであるSDT fattyラットの腎症の進展に及ぼす影響
        美谷島克宏; 太田毅; 篠原雅己; 岩崎日向子; Teoh Soon Hui; 宇野絹子; 煙山紀子; 中江大
        34th Japanese Society of Toxicologic Pathology, Jan. 2018
      • 若齢および高齢の雌性SDT fattyラットにおける腎病態
        Teoh Soon Hui; 美谷島克宏; 太田毅; 篠原雅己; 森元里香; 宇野絹子; 煙山紀子; 中江大
        34th Japanese Society of Toxicologic Pathology, Jan. 2018
      • 新規糖尿病性腎症モデルの作製と病態解析:SDT fattyラットの腎症進展に対する片腎摘出および食塩負荷の影響
        篠原雅巳; Francois Briand; Emmanuel Brousseau; 太田毅; 美谷島克宏; 影山靖; Thierry Sulpice
        29th Japan Diabetic Nephropathy Study, Dec. 2017
      • 10-week, but not 7-week, Dapagliflozin alone or in combination with ramipril improves hyperglycemia, hypertension, and prevents kidney complications and GFR decline in uninephrectomized SDT fatty rat, a 10-week model of diabetic nephropathy.
        Briand F; Shinohara M; Brousseau E; Ohta T; Kageyama Y; Sulpice T
        51th Kidney Week-ASN 2017, Nov. 2017
      • SDT fatty ratにおける糖尿病網膜症
        田中克明; 小林未奈; 高木理那; 上原志保; 豊田文彦; 榛村真知子; 木下望; 高野博子; 太田毅; 笹瀬智彦; 梯彰弘
        32nd The Japan Society of Diabetic Complications, Oct. 2017
      • 片腎摘出および食塩負荷が肥満2型糖尿病モデルSDT fattyラットの腎症進展に与える影響
        篠原雅巳; Francois Briand; Emmanuel Brousseau; 太田毅; 美谷島克宏; 影山靖; Thierry Sulpice
        32nd The Japan Society of Diabetic Complications, Oct. 2017
      • Diabetic peripheral neuropathy in SDT fatty rat, a new animal model of obese type2 diabetes.
        Sasase T; Maekawa T; Tadaki H; Motohashi Y; Miyajima K; Ohta T; Kume S
        Neurodiab 2017, Sep. 2017
      • Histopathological analysis of young and aged female Spontaneously Diabetic Torii fatty rats.
        Teoh SH; Miyajima K; Ohta T; Shinohara M; Uno K; Kemuriyama N; Nakae D
        4th ICAMBBE, Sep. 2017
      • New Animal Models of Type 2 diabetes –SDT and SDT Fatty Rat–,
        Ohta T
        Lunch talk:Seminar session, Laboratory Animal Trade Exhibition 2017, National Research Council of Thailand (NRCT), Jul. 2017, Invited
      • SDT fattyラットにおける12週間の0.3%食塩負荷による糖尿病合併症の病態進展に及ぼす影響
        Teoh Soon Hui; 美谷島克宏; 太田毅; 篠原雅己; 新里珠美; 宇野絹子; 煙山紀子; 中江大
        44th The Japanese Society of Toxicology, Jul. 2017
      • 10-week, but not 7-week, Dapagliflozin treatment improves severe renal impairment in Uninephrectomized SDT fatty rat, a 10-week model of advanced renal complications and glomerular filtration rate decline.
        Briand F; Shinohara M; Brousseau E; Ohta T; Kageyama Y; Sulpice T
        54th ERA-EDTA CONGRESS, MADRID 2017, Jun. 2017
      • Pathophysiological analyses of skeletal muscle in obese type 2 diabetes Spontaneously Diabetic Torii (SDT) fatty rats.
        Kemmochi Y; Ohta T; Kaneshige A; Katsumi S; Taniai-Riya E; Toyoda K; Anagawa-Nakamura A; Yasui Y; Takahashi A; Kakimoto K; Shoda T; Yamada T
        Society of Toxicologic Pathology, 36rd Annual Symposium, Jun. 2017
      • Experimental animals – The role in development of medicinal drugs-
        Takeshi Ohta
        国際基督教大学教養学部「生命科学A」, Apr. 2017, Invited
      • 10-week, but not 7-week, Dapagliflozin treatment improves severe renal impairment in the Uninephrectomized SDT fatty rat, a 10-week model of advanced renal complications and glomerular filtration rate decline.
        Briand F; Shinohara M; Brousseau E; Ohta T; Kageyama Y; Sulpice T
        ISN World Congress of Nephrology 2017, Apr. 2017
      • 糖尿病性腎症の臨床試験を見据えた動物モデルでの評価法と作製法
        太田毅
        Technical Information Institute Co., Ltd, Apr. 2017, Invited
      • SDT fattyラットにおける片腎摘出術及び食塩負荷が腎症進展に及ぼす影響-慢性腎臓病モデルの確立へ向けて-
        太田毅; 篠原雅巳; Francois Briand; Emmanuel Brousseau; 美谷島克宏; 影山靖; 勝田佳朋; 久米新一; Thierry Sulpice
        122nd Japanese Society of Animal Science, Mar. 2017
      • SDT fattyラットにおける片腎摘出術および食塩負荷が腎症進展におよぼす影響:糖尿病性腎症モデルの作製と病態解析
        篠原雅巳; Francois Briand; Emmanuel Brousseau; 太田毅; 美谷島克宏; 影山靖; Thierry Sulpice
        31st Japan Society of Experimental Diabetes and Obesity, Feb. 2017
      • Early onset of preliminary changes that progress into NASH-like lesions in STAM mice
        美谷島克宏; 太田毅; 石井幸仁; 煙山紀子; 中江大
        33rd Japanese Society of Toxicologic Pathology, Jan. 2017
      • 肥満2型糖尿病モデルSDT fattyラットに食塩負荷が及ぼす病態生理学的変化について
        篠原雅巳; 太田毅; 勝田佳朋; 剣持佑介; 槇美実; 佐野龍平; 石井幸仁; 美谷島克宏; 柿本恒知
        28th Japan Diabetic Nephropathy Study, Dec. 2016
      • New animal models of type 2 diabetes with diabetic complication -SDT and SDT fatty rat-,
        Shinohara M; Sasase T; Miyajima K; Ohta T
        Seminar in Mahidol University, Oct. 2016, Invited
      • Unilateral nephrectomy and salt supplementation in Spontaneously Diabetic Torii fatty rat expedites renal complications and glomerular filtration rate decline within 10 weeks.
        Briand F; Shinohara M; Brousseau E; Miyajima K; Ohta T; Kageyama Y; Sulpice T
        The New York Academy of Sciences, Sep. 2016
      • Drug therapy in type 2 diabetes and obesity – Microsomal triglyceride transfer protein (MTP) inhibitor –,
        Ohta T
        3rd International Conference on Advance Molecular Bioscience and Biomedical Engineering (ICAMBBE2016), Aug. 2016, Invited
      • 非アルコール性脂肪性肝炎(NASH)モデルであるSTAMマウスモデルの早期病変に関する病態解析
        美谷島克宏; 太田毅; 石井幸仁; 煙山紀子; 中江大
        第31回発癌病理研究会, Aug. 2016
      • Long-term glycemic control with insulin prevents the development of testicular interstitial cell tumors in Spontaneously Diabetic Torii rats.
        Ohta T; Kemmochi Y; Miyajima K; Sasase T; Matsui K; Ueda N; Shinohara M; Matsushita M
        76th ADA, Jun. 2016
      • 創薬研究開発-今後の動向-
        Takeshi Ohta
        日本クレア㈱セミナー, Jun. 2016, Invited
      • 実験動物-医薬品開発におけるその役割-
        Takeshi Ohta
        国際基督教大学教養学部「生命科学A」, Apr. 2016, Invited
      • 2型糖尿病合併症モデルSDTおよびSDT fatty ラット
        篠原雅巳; 太田毅; 笹瀬智彦; 石井幸仁; 美谷島克宏; 益山拓
        30th Japan Society of Experimental Diabetes and Obesity, Mar. 2016, Invited
      • A new strategy for the treatment of metabolic disease, with a focus on MGAT inhibitor.
        大熊千尋; 太田毅; 久米新一; 唯木洋暢; 濱田裕美; 小田知洋; 谷内英之; 石井幸仁; 石槫達也; 坂田昌平; 西宇淳; 角谷真
        89th The Japanese Pharmacological Society, Mar. 2016, Invited
      • 新規肥満2型糖尿病モデル雌性SDT fatty ラットにおけるNASH様病変の解析
        太田毅; 石井幸仁; 本橋雄; 村松真; 勝田佳朋; 美谷島克宏; 笹瀬智彦; 山田宜永; 松井徹; 篠原雅巳; 久米新一
        121st Japanese Society of Animal Science, Mar. 2016
      • 肥満2型糖尿病モデルSDT fatty ラットの糖尿病合併症におけるSGLT阻害薬の効果
        篠原雅巳; 太田毅; 勝田佳朋; 笹瀬智彦; 唯木洋暢; 米良泰子; 本橋雄; 剣持佑介; 豊田薫; 柿本恒知; 久米新一
        30th Japan Society of Experimental Diabetes and Obesity, Mar. 2016
      • 非アルコール性脂肪肝炎(NASH)の研究開発動向
        Takeshi Ohta
        日本クレア㈱セミナー, Mar. 2016, Invited
      • SDT fatty ラットを用いた脂肪性肝疾患に関する研究-新規NASHモデルの確立に向けて-
        石井幸仁; 本橋雄; 村松真; 勝田佳朋; 美谷島克宏; 笹瀬智彦; 久米新一; 山田宜永; 太田毅
        2015年度家畜栄養生理研究会秋季集談会, Oct. 2015
      • SDT fatty ratの病態解析-最新情報-
        Takeshi Ohta
        日本クレア㈱セミナー, Oct. 2015, Invited
      • Drug therapy in type 2 diabetes (Part 2): Protein tyrosine phosphatase 1B (PTP1B) inhibitor,
        Ohta T
        2nd International Conference on Advance Molecular Bioscience and Biomedical Engineering (ICAMBBE2015), Sep. 2015, Invited
      • Spontaneously Diabetic Torii (SDT) rat and SDT fatty rat -New Animal Models of Type 2 Diabetes- with Severe Diabetic Complications.
        Shinohara M; Sasase T; Miyajima K; Ohta T
        Korean Association for Laboratory Animal Science 2015 International Symposium, Aug. 2015, Invited
      • 代謝性疾患と医薬品開発
        Takeshi Ohta
        新潟大学農学部「動物遺伝学セミナー」, Jul. 2015, Invited
      • 肥満2型糖尿病モデル雌性SDT fatty ラットの糖尿病合併症におけるSGLT阻害薬の効果の検討
        太田毅; 勝田佳朋; 笹瀬智彦; 唯木洋暢; 米良泰子; 本橋雄; 剣持佑介; 豊田薫; 柿本恒知; 篠原雅巳; 久米新一
        119th Japanese Society of Animal Science, Mar. 2015
      • 肥満2型糖尿病モデル雌性SDT fatty ラットに認められたNASH様病変について
        篠原雅巳; 美谷島克宏; 剣持佑介; 勝田佳朋; 石井幸仁; 柿本恒知; 太田毅
        29th Japan Society of Experimental Diabetes and Obesity, Feb. 2015
      • 肥満2型糖尿病モデルSDT fattyラットにおける食塩負荷による病態生理学的変化の検討
        篠原雅巳; 太田毅; 勝田佳朋; 剣持佑介; 槇美実; 佐野龍平; 石井幸仁; 美谷島克宏; 柿本恒知
        29th Japan Society of Experimental Diabetes and Obesity, Feb. 2015
      • 雌性SDT fatty ラットに認められたNASH様病変の解析
        美谷島克宏; 太田毅; 勝田佳朋; 石井幸仁; 柿本恒知; 安井雄三; 剣持佑介; 中村明子; 豊田薫; 谷合枝里子; 高橋明美; 宮川義史; 正田俊之
        31st Japanese Society of Toxicologic Pathology, Jan. 2015
      • Drug therapy in type 2 diabetes: glucose sensor activator,
        Ohta T
        1st International Conference on Advance Molecular Bioscience and Biomedical Engineering (ICAMBBE2014), Sep. 2014, Invited
      • 代謝性疾患と医薬品開発
        Takeshi Ohta
        新潟大学農学部「動物遺伝学セミナー」, Jul. 2014, Invited
      • Spontaneously Diabetic Torii (SDT) rat and SDT fatty rat -New Animal Models of Type 2 Diabetes- with Severe Diabetic Complications.
        Shinohara M; Sasase T; Miyajima K; Ohta T
        Asian Symposium on Sciences of Oriental Medicine, Jul. 2014
      • Female SDT fatty rat shows Non-Alcoholic Steatohepatitis (NASH)-like hepatic lesions –pathophysiological analysis of liver in female Spontaneously Diabetic Torii fatty rats-.
        Miyajima K; Ohta T; Katsuda Y; Ishii Y; Kakimoto K; Yasui Y; Kemmochi Y; Nakamura A; Toyoda K; Taniai E; Takahashi A; Miyakawa Y; Shoda T
        Society of Toxicologic Pathology, 33rd Annual Symposium, Jun. 2014
      • 新規肥満糖尿病モデルSDT fattyラットにおける食塩負荷による病態生理学的変化の検討
        太田毅; 勝田佳朋; 剣持佑介; 槇美実; 佐野龍平; 石井幸仁; 篠原雅巳; 美谷島克宏; 柿本恒知
        118th Japanese Society of Animal Science, Mar. 2014
      • 肥満2型SDT fatty ラットへの食塩負荷による増悪化の検討
        剣持佑介; 勝田佳朋; 槇美実; 太田毅; 豊田薫; 美谷島克宏; 安井雄三; 中村明子; 谷合枝里子; 高橋明美; 柿本恒知; 宮川義史; 正田俊之
        30th Japanese Society of Toxicologic Pathology, Jan. 2014, Invited
      • 肥満2型糖尿病モデルSDT fattyラットにおける過食におけるグレリン分泌異常の関与
        田尻祐司; 西芳寛; 原健人; 副島恵理; 平田留美子; 太田毅; 笹瀬智彦; 細田洋司; 寒川賢治; 児島将康; 御船弘治; 山田研太郎
        63rd The Japanese Society of Constitutional Medicine, Oct. 2013
      • Overview (Diabetic animal model)
        Ohta T
        One day seminar and workshop (Animal model for human research disease model),, Sep. 2013, Invited
      • 雌性Spontaneously Diabetic Torii-Leprfa(SDT-fa/fa) ラットの生殖学的基礎検討
        稲葉信博; 中村早苗; 平尾直啓; 龍門徳彦; 千葉薫; 美谷島克宏; 太田毅
        47th Japanese Association for Experimental Animal Technologists, Sep. 2013, Invited
      • 新規肥満糖尿病モデルSDT fattyラットの腎病変に関する検討
        太田毅; 笹瀬智彦; 美谷島克宏; 剣持佑介; 篠原雅巳; Tong Bin; 杉山捻恵; 山田宜永
        117th Japanese Society of Animal Science, Sep. 2013
      • 代謝性疾患と医薬品開発
        Takeshi Ohta
        新潟大学農学部「動物遺伝学セミナー」, Jul. 2013, Invited
      • 肥満2型糖尿病モデルSDT fattyラットにおける過食とグレリン分泌動態
        原健人; 田尻祐司; 西芳寛; 副島恵理; 平田留美子; 太田毅; 笹瀬智彦; 山田研太郎; 細田洋司; 寒川賢治; 児島将康; 御船弘治
        第31回内分泌代謝学サマーセミナー, Jul. 2013
      • VEGFシグナル阻害はSDTラットにおける膵島β細胞障害と糖尿病発症を抑制する
        向英里; 太田毅; 河村治清; 笹瀬智彦; 李恩瑛; 森田亜州華; 稲垣暢也; 岩永敏彦; 三木隆司
        56th The Japan Diabetes Society, May 2013
      • 肥満2型糖尿病モデルSDT fattyラットにおける過食とグレリン分泌動態
        田尻祐司; 西芳寛; 原健人; 副島恵理; 平田留美子; 太田毅; 笹瀬智彦; 細田洋司; 寒川賢治; 児島将康; 御船弘治; 山田研太郎
        56th The Japan Diabetes Society, May 2013
      • 医薬品開発-代謝性疾患-
        太田毅
        近畿大学理工学部「特別講義II」, Mar. 2013, Invited
      • VEGFシグナル阻害はSDTラットにおける膵島β細胞障害と糖尿病発症を抑制する
        向英里; 太田毅; 河村治清; 笹瀬智彦; 李恩瑛; 森田亜州華; 稲垣暢也; 岩永敏彦; 三木隆司
        90th he Physiological Society of Japan, Mar. 2013
      • 肥満糖尿病モデルSDT fattyラットにおける過食とグレリン分泌動態の関与
        田尻祐司; 西芳寛; 原健人; 副島恵理; 平田留美子; 太田毅; 笹瀬智彦; 細田洋司; 寒川賢治; 児島将康; 御船弘治; 山田研太郎
        27th Japan Society of Experimental Diabetes and Obesity, Feb. 2013
      • SDTラットではVEGFシグナル亢進がβ細胞を障害し糖尿病を引き起こす
        向英里; 太田毅; 河村治清; 笹瀬智彦; 李恩瑛; 森田亜州華; 稲垣暢也; 岩永敏彦; 三木隆司
        27th The Japan Diabetes Society, Feb. 2013
      • Enhanced VEGF signaling in islets contributes to β-cell injury and consequential diabetes in SDT rats.
        Mukai E; Ohta T; Kawamura H; Lee E-Y; Morita A; Inagaki N; Iwanaga T; Miki T
        9th International Diabetes Federation Western Pacific Region Congress & 4th Scientific Meeting of the Asian Association for the Study of Diabetes, Nov. 2012
      • 代謝性疾患と医薬品開発
        太田毅
        新潟大学自然科学研究科「農と食の博士セミナー(第2回)」, Jul. 2012, Invited
      • Severely Progressed Diabetes-Associated Renal Complication in the Spontaneously Diabetic Torii (SDT) Fatty Rat at Ages over 50 Weeks – Histopathological Examination -.
        Kemmochi Y; Miyajima K; Yasui Y; Ohta T; Sasase T; Takahashi A; Toyoda K; Masuyama T; Shoda T; Kakimoto K
        Society of Toxicologic Pathology, 31st Annual Symposium, Jun. 2012
      • 創薬研究において病態モデル動物の果たす役割
        Takeshi Ohta
        東北大学大学院農学研究科「第135回動物生殖科学教室特別セミナー」, May 2012, Invited
      • 新規肥満2型糖尿病モデルSDT fatty ratの病態解析
        太田毅
        59th Japanese Association for Laboratory Animal Science -Luncheon Seminar-, May 2012, Invited
      • 簡易ガラス化法を用いたSpontaneously Diabetic Torii-Leprfa(SDT-fa/fa) rat の2細胞期胚の凍結保存
        龍門徳彦; 稲葉信博; 中村早苗; 平尾直啓; 前野孝之; 千葉薫; 笹瀬智彦; 太田毅
        Japanese Association for Experimental Animal Technologists 2012, May 2012, Invited
      • シンポジウム2「糖尿病モデル動物を用いた糖尿病合併症研究」-非肥満2型糖尿病モデルSDTラット-
        篠原雅巳; 太田毅; 笹瀬智彦
        26th Japan Society of Experimental Diabetes and Obesity, Feb. 2012
      • Spontaneously Diabetic Torii (SDT) fatty ラットにおける自然発生性ぶどう膜炎について:病理組織学的検討
        剣持佑介; 美谷島克宏; 安井雄三; 益山拓; 太田毅; 笹瀬智彦; 柿本恒知
        26th The Japan Society of Diabetic Complications, Oct. 2011
      • 肥満2型糖尿病モデルSDT fatty ラットにおける骨障害
        木村修一; 笹瀬智彦; 太田毅; 松下睦佳
        26th The Japan Society of Diabetic Complications, Oct. 2011
      • 代謝性疾患と医薬品開発
        Takeshi Ohta
        新潟大学農学部「動物遺伝学セミナー」, Jun. 2011, Invited
      • 代謝性疾患と創薬研究
        Takeshi Ohta
        東北大学大学院農学研究科「第127回動物生殖科学教室特別セミナー」, May 2011, Invited
      • The SDT rat: A new animal model of non-obese type 2 diabetes with diabetic complications.
        Shinohara M; Masuyama T; Ohta T; Sasase T; Yokoi N; Kakehashi A
        第18回国際ラット遺伝システムワークショップ, Nov. 2010
      • 代謝性疾患と医薬品開発
        Takeshi Ohta
        新潟大学農学部「動物遺伝学セミナー, Jul. 2010, Invited
      • 新規糖尿病性合併症モデルと創薬研究への応用
        Takeshi Ohta
        東北大学大学院農学研究科「第118回動物生殖科学教室特別セミナー」, Apr. 2010, Invited
      • 創薬研究と新規モデル動物の開発
        Takeshi Ohta
        東北大学大学院農学研究科「第112回動物生殖科学教室特別セミナー」, Apr. 2009, Invited
      • :GPR40アゴニストの新規糖尿病治療薬としての可能性
        松井謙一; 加藤亮; 中根由富; 石井幸仁; 太田毅
        第11回血管障害研究会, Apr. 2009
      • 肥満2型糖尿病モデルSDT fattyラットの膵臓に制限給餌が及ぼす影響
        石井幸仁; 太田毅; 笹瀬智彦; 森長寿代; 上田正俊; 美谷島克宏; 角谷真
        23rd Japan Society of Experimental Diabetes and Obesity, Feb. 2009
      • 糖尿病の創薬研究とモデル動物
        Takeshi Ohta
        東北大学大学院農学研究科「第109回動物生殖科学教室特別セミナー」, May 2008, Invited
      • 新規2型糖尿病モデルSDT fattyラットの病態に摂餌制限が及ぼす影響
        石井幸仁; 太田毅; 松井謙一; 森長寿代; 笹瀬智彦; 福田純明; 伊藤誠; 上田正俊; 美谷島克宏; 松下睦佳
        22nd Japan Society of Experimental Diabetes and Obesity, Feb. 2008
      • PKCβ inhibitor prevents early diabetic complications, but does not prevent histopathological abnormalities of retina in SDT rat.
        Sasase T; Morinaga H; Ohta T; Miyajima K; Masuyama T; Matsushita M; Yonemori F; Shinohara M; Kakehashi A; Kanazawa Y
        67th ADA, Jun. 2007
      • SDT fattyラットの糖尿病態に関する基礎的検討
        太田毅; 上田順久; 小田知洋; 森長寿代; 伊藤誠; 福田純明; 小川直人; 美谷島克宏; 笹瀬智彦; 松下睦佳
        第4回SDTラット研究会, Dec. 2006
      • SDTラットの糖尿病合併症に対するPKCβ阻害剤の作用
        笹瀬智彦; 森長寿代; 益山拓; 美谷島克宏; 太田毅; 松下睦佳; 篠原雅巳; 梯彰弘; 金澤康徳
        第4回SDTラット研究会, Dec. 2006
      • 新規糖尿病治療薬の開発
        Takeshi Ohta
        東北大学大学院農学研究科「第101回動物生殖科学教室特別セミナー」, May 2006, Invited
      • Spontaneously Diabetic Torii (SDT) ラットの脂質代謝に関する基礎的研究
        笹瀬智彦; 山本裕美; 森長寿代; 小川直人; 河合孝; 米良泰子; 美谷島克宏; 益山拓; 篠原雅巳; 太田毅; 角谷真; 松下睦佳
        53rd Japanese Association for Laboratory Animal Science, May 2006
      • Spontaneously Diabetic Torii (SDT) ラットの脂肪吸収と食後高TG血症に関する基礎的検討
        笹瀬智彦; 山本裕美; 森長寿代; 小川直人; 河合孝; 米良泰子; 美谷島克宏; 益山拓; 篠原雅巳; 太田毅; 角谷真; 松下睦佳
        79th The Japanese Pharmacological Society, Mar. 2006
      • SDTラットの脂質代謝に関する検討
        小川直人; 笹瀬智彦; 山本裕美; 森長寿代; 河合孝; 米良泰子; 美谷島克宏; 太田毅; 角谷真; 松下睦佳
        第3回SDTラット研究会, Dec. 2005
      • SDTラットの単離膵ラ氏島を用いたインスリン分泌能の検討
        松井謙一; 小田知洋; 山本裕美; 福田純明; 笹瀬智彦; 美谷島克宏; 太田毅; 松下睦佳
        第3回SDTラット研究会, Dec. 2005
      • Diabetic complications of Spontaneously Diabetic Torii rat.
        Sasase T; Ohta T; Ogawa N; Miyajima K; Koizumi H; Matsushita M; Kanazawa Y
        65th ADA, Jun. 2005
      • SDTラット肝臓の糖代謝に関する検討
        森長寿代; 山本裕美; 笹瀬智彦; 美谷島克宏; 太田毅; 松下睦佳
        第2回SDTラット研究会, Dec. 2004
      • SDTラットにおける腎臓病変の経時的変化について
        美谷島克宏; 太田毅; 笹瀬智彦; 松下睦佳; 益山拓; 岩坂俊基; 小泉治子
        第2回SDTラット研究会, Dec. 2004
      • インスリン治療によるSpontaneously Diabetic Torii (SDT) ラットの眼病変改善
        笹瀬智彦; 太田毅; 小川直人; 美谷島克宏; 松下睦佳
        第111回薬理学会関東部会, Oct. 2004
      • 血糖コントロールによるSpontaneously Diabetic Torii (SDT) ラットの眼病変改善
        笹瀬智彦; 太田毅; 小川直人; 美谷島克宏; 松下睦佳
        19th The Japan Society of Diabetic Complications, Oct. 2004
      • 血糖コントロールによるSpontaneously Diabetic Torii (SDT) ラットの眼病変改善
        笹瀬智彦; 太田毅; 小川直人; 美谷島克宏; 松下睦佳
        第7回血管障害研究会, Aug. 2004
      • 糖尿病の創薬研究
        Takeshi Ohta
        東北大学大学院農学研究科「第84回動物生殖科学教室特別セミナー」, Apr. 2004, Invited
      • SDTラットの糖尿病網膜症モデルとしての有用性
        笹瀬智彦; 小川直人; 太田毅; 松下睦佳
        第1回SDTラット研究会, Dec. 2003
      • Protein-Tyrosine Phosphatase 1B as New Activator for Hepatic Lipogenesis Via Sterol Regulatory Element-Binding Protein-1 Gene Expression
        Maegawa H; Shimizu S; Ugi S; Yoshizaki T; Egawa K; Nishio Y; Ohta T; Iwasaka T; Bryer-Ash M; Kashiwagi A
        63rd ADA, Jun. 2003
      • The Effects of a γ-Ketocarbonic Acid Derivative on GLP-1 and Insulin Secretion in Rat.
        Manaka H; Ohnuma H; Ohta T; Eguchi H; Yamaguchi H; Kimura M; Daimon M; Yamantani K; Kato T; Sasaki H
        58th ADA, Jun. 1998
      • 新規糖尿病治療薬JTT-608の膵ラ氏島に対するインスリン分泌促進効果とその作用機序
        向英里; 石田均; 藤本新平; 古川昇; 太田毅; 津浦佳之; 西村正仁; 水野展寿; 梶川麻里子; 清野裕
        41st The Japan Diabetes Society, May 1998
      • GLP-1分泌に及ぼすJTT-608の効果
        間中英夫; 太田毅; 大沼寛; 木村守; 山口宏; 江口英行; 大門真; 山谷恵一; 佐々木英夫; 加藤丈夫
        41st The Japan Diabetes Society, May 1998
      • ヤギ卵管上皮の電子顕微鏡観察.
        宮本元; 森田真紀; 太田毅
        第39回日本畜産学会関西支部会, Sep. 1989
      • ブタ・イノシシ・イノブタの卵巣における卵胞と卵母細胞の相対的発育.
        宮本元; 太田毅
        3rd Japanese Society of Animal Reproductive Technology, 1989
      • Usefulness of obese animal models in antiobesity drug development. In: Adiposity - Omics and Molecular Understanding
        Ohta T; Murai Y; Yamada T, Joint work
        Jan Oxholm Gordeladze ed., In Tech, 2017, Not refereed
      • Current status of medical therapy and new targets for anti-obesity drug development.Anti-Obesity Drug Discovery and Development
        Okuma C; Ishii Y; Ohta T, Joint work
        Bentham Science Publishers, 2017, Not refereed
      • 第5節 糖尿病性腎症の発症メカニズム、創薬への応用と動物試験の評価指標-動物/疾患モデルの作製技術・病態解析・評価指標. 第9章 生活習慣病領域におけるモデル動物の作成法と最新メカニズム・創薬応用.
        Shinohara M; Ohta T, Joint work
        Technical Information Institute Co., Ltd, 2017, Not refereed
      • 第4節 糖尿病性腎症における動物モデルの作製手法-動物/疾患モデルの作製技術・病態解析・評価手法. 第9章 生活習慣病領域におけるモデル動物の作成法と最新メカニズム・創薬応用.
        Shinohara M; Ohta T, Joint work
        Technical Information Institute Co., Ltd, 2017, Not refereed
      • Type 2 diabetic animal models, In: Glucose Tolerance
        Ishii Y; Ohta T; Sasase T, Joint work
        AV Dreval ed., In Tech, 2012, Not refereed

      Industrial Property Rights

      • 特開WO2021045161, 特願WO2020JP3346 20200903, Chronic kidney disease treatment or prevention method
        SANO RYUHEI; YAMANAKA MASAO; OHTA TAKESHI
      • 特開WO2020054734, 特願WO2019JP35586 20190910, Therapeutic or prophylactic agent for chronic kidney disease containing pyrazole-amide compound
        Saito tomoyuki; Ohta takeshi; Kakutani makoto; Mera yasuko
      • 特開2005-272476, 複素芳香5員環化合物及びその医薬用途
        池本知之; 田中正浩; 油納健夫; 坂本丞平; 中西博行; 中川祐一; 太田毅; 坂田昌平; 森長寿代
      • 特開2002-114768, 2-(2,5-ジハロゲン-3,4-ジヒドロキシフェニル)アゾール化合物及びそれを含有してなる医薬組成物
        稲葉隆之; 池本知之; 太田毅
      • 特開2000-191588, シクロ化合物及びその医薬用途
        新海久; 小関英和; 太田毅

      Awards

      • May 2009
        Japanese Association for Laboratory Animal Science, 2008年Experimental Animals最優秀論文賞
      • Mar. 2012
        Japanese Society of Animal Science , Animal Science Journal Excellent Paper Award
      • May 2012
        Japanese Association for Experimental Animal Technologists, 第31回研究奨励賞
      • Sep. 2013
        Japanese Association for Experimental Animal Technologists, 第32回研究奨励賞
      • Sep. 2018
        International Conference on Advance Molecular Bioscience & Biomedical Engineering (ICAMBBE), Annually Contribution Speaker Award
      • Feb. 2019
        Japanese Society of Toxicologic Pathology, 2018年度JTP最優秀論文賞
      • 01 Apr. 2022
        WILEY, Top Cited Article 2020-2021
        JOURNAL OF DIABETES INVESTIGATION Sodium-glucose cotransporters: Functional properties and pharmaceutical potential, Official journal
        Ryuhei Sano, Yuichi Shinozaki, Takeshi Ohta
      list
        Last Updated :2022/09/30

        Education

        Teaching subject(s)

        • From 01 Apr. 2022, To 31 Mar. 2023
          Laboratory Course in Animal Physiology and Anatomy2
          DC35, Year-long, Graduate School of Agriculture, 6
        • From 01 Apr. 2022, To 31 Mar. 2023
          Seminar in Animal Physiology and Anatomy1
          DB34, Year-long, Graduate School of Agriculture, 3
        • From 01 Apr. 2022, To 31 Mar. 2023
          Thesis
          5309, Year-long, Faculty of Agriculture, 10
        • From 01 Apr. 2022, To 31 Mar. 2023
          Laboratory Course in Animal Physiology and Anatomy1
          DC34, Year-long, Graduate School of Agriculture, 6
        • From 01 Apr. 2022, To 31 Mar. 2023
          Animal Physiology and Anatomy
          5160, Spring, Faculty of Agriculture, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Practical Course in Applied Animal Science II
          1046, Spring, Faculty of Agriculture, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Animal Pathophysiology
          DA56, Fall, Graduate School of Agriculture, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Seminar in Animal Physiology and Anatomy2
          DB35, Year-long, Graduate School of Agriculture, 3
        • From 01 Apr. 2022, To 31 Mar. 2023
          Outline of Bioresource Science A
          5112, Spring, Faculty of Agriculture, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Animal Molecular Physiology I
          5340, Fall, Faculty of Agriculture, 2
        • From Apr. 2019, To Mar. 2020
          Laboratory Course in Animal Physiology and Anatomy1
          Year-long, 農学研究科
        • From Apr. 2019, To Mar. 2020
          Laboratory Course in Animal Physiology and Anatomy2
          Year-long, 農学研究科
        • From Apr. 2019, To Mar. 2020
          Seminar in Animal Physiology and Anatomy1
          Year-long, 農学研究科
        • From Apr. 2019, To Mar. 2020
          Seminar in Animal Physiology and Anatomy2
          Year-long, 農学研究科
        • From Apr. 2019, To Mar. 2020
          Animal Physiology and Anatomy
          Fall, 農学研究科
        • From Apr. 2020, To Mar. 2021
          Animal Molecular Physiology
          Fall, 農学部
        • From Apr. 2020, To Mar. 2021
          Animal Physiology and Anatomy
          Spring, 農学部
        • From Apr. 2020, To Mar. 2021
          Animal Pathophysiology
          Fall, 農学研究科
        • From Apr. 2020, To Mar. 2021
          Practical Course in Applied Animal Science II
          Spring, 農学部
        • From Apr. 2020, To Mar. 2021
          Laboratory Course in Animal Physiology and Anatomy1
          Year-long, 農学研究科
        • From Apr. 2020, To Mar. 2021
          Laboratory Course in Animal Physiology and Anatomy2
          Year-long, 農学研究科
        • From Apr. 2020, To Mar. 2021
          Seminar in Animal Physiology and Anatomy1
          Year-long, 農学研究科
        • From Apr. 2020, To Mar. 2021
          Seminar in Animal Physiology and Anatomy2
          Year-long, 農学研究科
        • From Apr. 2020, To Mar. 2021
          Outline of Bioresource Science A
          Spring, 農学部
        • From Apr. 2021, To Mar. 2022
          Animal Molecular Physiology
          Fall, 農学部
        • From Apr. 2021, To Mar. 2022
          Animal Physiology and Anatomy
          Spring, 農学部
        • From Apr. 2021, To Mar. 2022
          Practical Course in Applied Animal Science II
          Spring, 農学部
        • From Apr. 2021, To Mar. 2022
          Laboratory Course in Animal Physiology and Anatomy1
          Year-long, 農学研究科
        • From Apr. 2021, To Mar. 2022
          Laboratory Course in Animal Physiology and Anatomy2
          Year-long, 農学研究科
        • From Apr. 2021, To Mar. 2022
          Seminar in Animal Physiology and Anatomy1
          Year-long, 農学研究科
        • From Apr. 2021, To Mar. 2022
          Seminar in Animal Physiology and Anatomy2
          Year-long, 農学研究科
        • From Apr. 2021, To Mar. 2022
          Animal Physiology and Anatomy
          Fall, 農学研究科
        • From Apr. 2021, To Mar. 2022
          Outline of Bioresource Science A
          Spring, 農学部

        Participation in PhD Defenses (other than KU)

        • 肥満2型糖尿病モデルSDT fattyラットを用いた非アルコール性脂肪肝炎及び糖尿病黄斑浮腫に関する解析
          本橋雄, 新潟大学, 242: JP, Sub-chief Examiner
          17 Feb. 2018
        • 肥満2型糖尿病モデルSDT fattyラットを用いた肥満・糖尿病性サルコペニアに関する解析
          剣持佑介, 新潟大学, 242: JP, Sub-chief Examiner
          17 Feb. 2018
        • 肥満2型糖尿病モデルSDT fattyラットにおける非アルコール性脂肪肝炎(NASH)発症の早期化の検討と各種薬剤の薬効評価
          鳥庭靖文, 新潟大学, 242: JP, Sub-chief Examiner
          15 Feb. 2019
        • 肥満2型糖尿病モデルSDT fattyラットにおけるメトホルミンの作用解析および血行動態の病態解析
          村井康高, 新潟大学, 242: JP, Sub-chief Examiner
          17 Feb. 2020
        • 高リン血症治療薬クエン酸第二鉄の新規生理学的機序の解明
          飯田聡夫, 新潟大学, 242: JP, Sub-chief Examiner
          17 Feb. 2020
        • GPR119agonist(JTP-109192)の代謝性疾患モデルにおける薬効解析
          唯木洋暢, 新潟大学, 242: JP, Sub-chief Examiner
          17 Feb. 2021

        Student achievements: Awards

        • The Best Presenter Award
          唯木洋暢, Smart Molecule of Natural Genetics Resource, Aug. 2020
        • 優秀発表賞
          太田愛理, 関西畜産学会, Oct. 2020
        • The Best Presenter Award
          前川竜也, Asian Federation of Biotechnology, Aug. 2021
        list
          Last Updated :2022/09/30

          Administration

          Faculty management (title, position)

          • From 01 Apr. 2022, To 31 Mar. 2024
            資源生物科学科長
          • From 01 Apr. 2020, To 31 Mar. 2021
            応用生物科学専攻長
          • From 01 Apr. 2020, To 31 Mar. 2023
            評価委員会 委員
          • From 01 Apr. 2020, To 31 Mar. 2021
            農場・牧場連絡協議委員会 委員
          • From 01 Apr. 2020, To 31 Mar. 2022
            防火・防災委員会 委員
          • From 01 Apr. 2021, To 31 Mar. 2023
            建築委員会 委員
          list
            Last Updated :2022/09/30

            Academic, Social Contribution

            Committee Memberships

            • From 2021, To Present
              評議員, 関西実験動物研究会
            • From 2020, To Present
              世話人, 畜産学教育協議会

            Academic Contribution

            • JSMARTech: Journal of Smart Bioprospecting and Technology
              Supervision (editorial)
              From 2019, To Present
            • The 4th International Seminar on Smart Molecule of Natural Resources (ISSMART) - Asian Federation of Biotechnology (AFOB) 2022
              Supervision (editorial)
              From 24 Aug. 2022, To 25 Aug. 2022

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