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Onuma, Kunishige

Graduate School of Medicine Program-Specific Assistant Professor

Onuma, Kunishige
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    Last Updated :2025/06/20

    Basic Information

    Academic Degree

    • 博士（医科学）(山形大学)
    • 修士（生命環境医科学）(山形大学)

    ID,URL

    researchmap URL

    list
      Last Updated :2025/06/20

      Research

      Papers

      • Dynamic change of polarity in spread through air spaces of pulmonary malignancies
        Yoshiaki Matsuura; Kunishige Onuma; Roberto Coppo; Hiroyuki Uematsu; Jumpei Kondo; Aya Miyagawa‐Hayashino; Naoko Takeda‐Miyata; Kenji Kameyama; Tatsuo Furuya; Satoru Okada; Masanori Shimomura; Masayoshi Inoue; Masahiro Inoue
        The Journal of Pathology, 13 Jan. 2025
        Access this paper :
      • Growth pattern of de novo small clusters of colorectal cancer is regulated by Notch signaling at detachment
        Yi‐Kai Lin; Roberto Coppo; Kunishige Onuma; Hiroko Endo; Jumpei Kondo; Sadahiro Iwabuchi; Shinichi Hashimoto; Yoshiro Itatani; Kazutaka Obama; Masahiro Inoue
        Cancer Science, 19 Sep. 2024
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      • Spread Through Air Spacesにおけるがん細胞塊極性の役割
        松浦 吉晃; 小沼 邦重; 下村 雅律; 岡田 悟; 内堀 篤樹; 井上 匡美; 井上 正宏
        日本胸部外科学会定期学術集会, Oct. 2023
      • Spread Through Air Spacesにおけるがん細胞塊極性の役割
        松浦 吉晃; 小沼 邦重; 下村 雅律; 岡田 悟; 内堀 篤樹; 井上 匡美; 井上 正宏
        日本胸部外科学会定期学術集会, Oct. 2023
      • 機能的な単一細胞解析による大腸癌内の相互転換可能な細胞亜集団の解明(Distinct but interchangeable subpopulations of colorectal cancer cells with different growth fates and drug sensitivity)
        コッポ・ロベルト; 近藤 純平; 小沼 邦重; 井上 正宏
        日本癌学会総会記事, Sep. 2023
      • 大腸腺腫の増殖幅の獲得は大腸発がん過程に関与する(Acquisition of wide proliferative range of adenoma cells played a role in adenomacarcinoma sequence)
        角南 智彦; コッポ・ロベルト; 小沼 邦重; 山田 敦; 武藤 学; 井上 正宏
        日本癌学会総会記事, Sep. 2023
      • Micropapillary carcinomaの極性転換不全を標的とした治療戦略(Therapeutic strategies targeting impaired polarity switching in micropapillary carcinoma)
        小沼 邦重; 井上 正宏
        日本癌学会総会記事, Sep. 2023
      • Ultra-Rapid and Specific Gelation of Collagen Molecules for Transparent and Tough Gels by Transition Metal Complexation
        Tomoyuki Suezawa; Naoko Sasaki; Nazgul Assan; Yuta Uetake; Kunishige Onuma; Hidehiro Sakurai; Ryohei Katayama; Masahiro Inoue; Michiya Matsusaki
        23 Mar. 2023, Peer-reviewed
      • Clonal Origin and Lineage Ambiguity in Mixed Neuroendocrine Carcinoma of the Uterine Cervix
        Masamune Masuda; Keita Iida; Sadahiro Iwabuchi; Mie Tanaka; Satoshi Kubota; Hiroyuki Uematsu; Kunishige Onuma; Yoji Kukita; Kikuya Kato; Shoji Kamiura; Aya Nakajima; Roberto Coppo; Mizuki Kanda; Kiyoshi Yoshino; Yutaka Ueda; Eiichi Morii; Tadashi Kimura; Jumpei Kondo; Mariko Okada-Hatakeyama; Shinichi Hashimoto; Masahiro Inoue
        The American Journal of Pathology, Mar. 2024
      • De-differentiation in cultures of organoids from luminal-type breast cancer is restored by inhibition of NOTCH signaling.
        Hiroyuki Uematsu; Chieko Saito; Jumpei Kondo; Kunishige Onuma; Roberto Coppo; Yukiko Mori; Manabu Muto; Yuichiro Kikawa; Manami Tada; Tomoharu Sugie; Masahiro Inoue
        Human cell, 27 Aug. 2023
      • Tracking the growth fate of single cells and isolating slow-growing cells in human colorectal cancer organoids.
        Roberto Coppo; Jumpei Kondo; Kunishige Onuma; Masahiro Inoue
        STAR protocols, 28 Jun. 2023
      • Inhibition of the bone morphogenetic protein pathway suppresses tumor growth through downregulation of epidermal growth factor receptor in MEK/ERK-dependent colorectal cancer.
        Shota Shimizu; Jumpei Kondo; Kunishige Onuma; Roberto Coppo; Kasumi Ota; Mayumi Kamada; Yohei Harada; Yoshihisa Tanaka; Mai Adachi Nakazawa; Yoshinori Tamada; Yasushi Okuno; Kenji Kawada; Kazutaka Obama; Robert J Coffey; Yoshiyuki Fujiwara; Masahiro Inoue
        Cancer science, 25 Jun. 2023
      • Oxygen metabolism analysis of a single organoid toward the noninvasive discrimination of cancer subpopulations with different growth capabilities
        Yuji Nashimoto; Shotaro Shishido; Kunishige Onuma; Kosuke Ino; Masahiro Inoue; Hitoshi Shiku
        Frontiers in Bioengineering and Biotechnology, May 2023, Peer-reviewed
      • Hepatocyte differentiation from mouse liver ductal organoids by transducing 4 liver-specific transcription factors
        Katsuhiro Tomofuji; Jumpei Kondo; Kunishige Onuma; Roberto Coppo; Hiroshi Horie; Koki Oyama; Eiji Miyoshi; Ken Fukumitsu; Takamichi Ishii; Etsuro Hatano; Masahiro Inoue
        Hepatology Communications, 14 Apr. 2023
      • Ex vivo chemosensitivity assay using primary ovarian cancer organoids for predicting clinical response and screening effective drugs.
        Yu Ito; Jumpei Kondo; Masamune Masuda; Shinya Matsuzaki; Kunishige Onuma; Mizuki Kanda; Yuko Watanabe; Hitomi Sakaguchi; Kiyoshi Yoshino; Yutaka Ueda; Shoji Kamiura; Tadashi Kimura; Masahiro Inoue
        Human cell, Mar. 2023
      • Pivotal role for S-nitrosylation of DNA methyltransferase 3B in epigenetic regulation of tumorigenesis.
        Kosaku Okuda; Kengo Nakahara; Akihiro Ito; Yuta Iijima; Ryosuke Nomura; Ashutosh Kumar; Kana Fujikawa; Kazuya Adachi; Yuki Shimada; Satoshi Fujio; Reina Yamamoto; Nobumasa Takasugi; Kunishige Onuma; Mitsuhiko Osaki; Futoshi Okada; Taichi Ukegawa; Yasuo Takeuchi; Norihisa Yasui; Atsuko Yamashita; Hiroyuki Marusawa; Yosuke Matsushita; Toyomasa Katagiri; Takahiro Shibata; Koji Uchida; Sheng-Yong Niu; Nhi B Lang; Tomohiro Nakamura; Kam Y J Zhang; Stuart A Lipton; Takashi Uehara
        Nature communications, 04 Feb. 2023
      • Distinct but interchangeable subpopulations of colorectal cancer cells with different growth fates and drug sensitivity
        Roberto Coppo; Jumpei Kondo; Keita Iida; Mariko Okada; Kunishige Onuma; Yoshihisa Tanaka; Mayumi Kamada; Masayuki Ohue; Kenji Kawada; Kazutaka Obama; Masahiro Inoue
        iScience, Feb. 2023
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      • Inhibition of the BMP pathway suppresses tumor growth via downregulation of EGFR in MEK/ERK-dependent colorectal cancer
        Shota Shimizu; Jumpei Kondo; Kunishige Onuma; Kasumi Ota; Mayumi Kamada; Yohei Harada; Yoshihisa Tanaka; Mai Adachi Nakazawa; Yoshinori Tamada; Yasushi Okuno; Kenji Kawada; Kazutaka Obama; Robert J Coffey; Yoshiyuki Fujiwara; Masahiro Inoue
        02 Nov. 2022
      • Electrochemical sensing of oxygen metabolism for a three-dimensional cultured model with biomimetic vascular flow.
        Yuji Nashimoto; Rei Mukomoto; Takuto Imaizumi; Takato Terai; Shotaro Shishido; Kosuke Ino; Ryuji Yokokawa; Takashi Miura; Kunishige Onuma; Masahiro Inoue; Hitoshi Shiku
        Biosensors & bioelectronics, 22 Oct. 2022
      • オルガノイドを用いたがん気道内転移モデルによるSTASの病態検証
        松浦 吉晃; 小沼 邦重; 下村 雅律; 内堀 篤樹; 井上 匡美; 井上 正宏
        日本胸部外科学会定期学術集会, Oct. 2022
      • 機能的な単一細胞解析による大腸癌内の相互転換可能な細胞亜集団の解明(Subpopulations with distinct and interchangeable capacity of spheroid formation and growth in colorectal cancer)
        コッポ・ロベルト; 近藤 純平; 小沼 邦重; 井上 正宏
        日本癌学会総会記事, Sep. 2022
      • Micropapillary carcinoma病態における極性転換不全とその分子機構(Molecular mechanism of impaired polarity switching in micropapillary carcinoma)
        小沼 邦重; 井上 正宏
        日本癌学会総会記事, Sep. 2022
      • ER陽性乳がんオルガノイドにおけるin vitroでの継代によるER発現の減弱(Attenuation of ER expression in the ER-positive breast cancer organoids by passages in vitro)
        上松 弘幸; 小沼 邦重; 杉江 知治; 井上 正宏
        日本癌学会総会記事, Sep. 2022
      • 子宮頸部神経内分泌腫瘍の混合腫瘍におけるクローン起源と分化系列の可塑的な決定(Clonal origin and plastic lineage determination in a mixed tumor of neuroendocrine carcinoma of the uterine cervix)
        益田 真志; 小沼 邦重; 井上 正宏
        日本癌学会総会記事, Sep. 2022
      • Abnormality of apico-basal polarity in adenocarcinoma.
        Kunishige Onuma; Masahiro Inoue
        Cancer science, 01 Sep. 2022
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      • Polarity switching of ovarian cancer cell clusters via SRC family kinase is involved in the peritoneal dissemination.
        Mayuko Kawata; Jumpei Kondo; Kunishige Onuma; Yu Ito; Takeshi Yokoi; Junzo Hamanishi; Masaki Mandai; Tadashi Kimura; Masahiro Inoue
        Cancer science, 18 Jul. 2022
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      • Distinct and interchangeable growing patterns in colorectal cancer stem-like cells are regulated by Musashi-1
        Roberto Coppo; Jumpei Kondo; Keita Iida; Mariko Okada; Kunishige Onuma; Yoshihisa Tanaka; Mayumi Kamada; Masayuki Ohue; Kenji Kawada; Kazutaka Obama; Masahiro Inoue
        26 Nov. 2021
      • 大腸がん転移におけるがん細胞集団の極性転換の役割
        小沼 邦重; 近藤 純平; 井上 正宏
        日本癌学会総会記事, Sep. 2021
      • Aberrant activation of Rho/ROCK signaling in impaired polarity switching of colorectal micropapillary carcinoma.
        Kunishige Onuma; Yumi Sato; Hiroaki Okuyama; Hiroyuki Uematsu; Keiichiro Homma; Masayuki Ohue; Jumpei Kondo; Masahiro Inoue
        The Journal of pathology, Sep. 2021
      • Heterogenous chemosensitivity of a panel of organoid lines derived from small cell neuroendocrine carcinoma of the uterine cervix.
        Mie Tanaka; Jumpei Kondo; Kensuke Kaneko; Hiroko Endo; Kunishige Onuma; Roberto Coppo; Masamune Masuda; Shoji Kamiura; Kiyoshi Yoshino; Yutaka Ueda; Hideaki Kakeya; Tadashi Kimura; Masahiro Inoue
        Human cell, May 2021
      • Loss of the cystine/glutamate antiporter in melanoma abrogates tumor metastasis and markedly increases survival rates of mice.
        Mami Sato; Kunishige Onuma; Mio Domon; Shun Hasegawa; Ami Suzuki; Ryosuke Kusumi; Remi Hino; Nahoko Kakihara; Yusuke Kanda; Mitsuhiko Osaki; Junichi Hamada; Shiro Bannai; Regina Feederle; Katalin Buday; José Pedro Friedmann Angeli; Bettina Proneth; Marcus Conrad; Futoshi Okada; Hideyo Sato
        International journal of cancer, 01 Dec. 2020
      • Small subset of Wnt-activated cells is an initiator of regrowth in colorectal cancer organoids after irradiation.
        Hiroko Endo; Jumpei Kondo; Kunishige Onuma; Masayuki Ohue; Masahiro Inoue
        Cancer science, Dec. 2020
      • Bisphosphonate-induced reactive oxygen species inhibit proliferation and migration of oral fibroblasts: A pathogenesis of bisphosphonate-related osteonecrosis of the jaw.
        Naomi Taniguchi; Mitsuhiko Osaki; Kunishige Onuma; Mizuho Ishikawa; Kazuo Ryoke; Isamu Kodani; Futoshi Okada
        Journal of periodontology, Jul. 2020
      • Dedifferentiation of neuroendocrine carcinoma of the uterine cervix in hypoxia.
        Satoshi Kubota; Mie Tanaka; Hiroko Endo; Yu Ito; Kunishige Onuma; Yutaka Ueda; Shoji Kamiura; Kiyoshi Yoshino; Tadashi Kimura; Jumpei Kondo; Masahiro Inoue
        Biochemical and biophysical research communications, 02 Apr. 2020
      • Synthesis and biological evaluation of glucose conjugated phthalocyanine as a second-generation photosensitizer.
        Yoshiyuki Uruma; Loghapriya Sivasamy; Priscilla Mei Yen Yoong; Kunishige Onuma; Yuto Omura; Matsumi Doe; Mitsuhiko Osaki; Futoshi Okada
        Bioorganic & medicinal chemistry, 01 Aug. 2019
      • Correlation of two distinct metastasis-associated proteins, MTA1 and S100A4, in angiogenesis for promoting tumor growth.
        Mizuho Ishikawa; Mitsuhiko Osaki; Makoto Yamagishi; Kunishige Onuma; Hisao Ito; Futoshi Okada; Hideya Endo
        Oncogene, Jun. 2019
      • Shortcuts to intestinal carcinogenesis by genetic engineering in organoids.
        Yoshiaki Maru; Kunishige Onuma; Masako Ochiai; Toshio Imai; Yoshitaka Hippo
        Cancer science, Mar. 2019
      • Fascin protein stabilization by miR-146a implicated in the process of a chronic inflammation-related colon carcinogenesis model.
        Yusuke Kanda; Tokuichi Kawaguchi; Mitsuhiko Osaki; Kunishige Onuma; Takahiro Ochiya; Tomoyuki Kitagawa; Futoshi Okada
        Inflammation research : official journal of the European Histamine Research Society ... [et al.], Oct. 2018
      • Lysosome-associated membrane protein 2 (LAMP-2) expression induced by miR-194-5p downregulation contributes to sunitinib resistance in human renal cell carcinoma cells.
        Tetsuya Yumioka; Mitsuhiko Osaki; Ryo Sasaki; Noriya Yamaguchi; Kunishige Onuma; Hideto Iwamoto; Shuichi Morizane; Masashi Honda; Atsushi Takenaka; Futoshi Okada
        Oncology letters, Jan. 2018
      • Ozone augments interleukin-8 production induced by ambient particulate matter.
        Jun Kurai; Kunishige Onuma; Hiroyuki Sano; Futoshi Okada; Masanari Watanabe
        Genes and environment : the official journal of the Japanese Environmental Mutagen Society, 2018
      • Identification of MicroRNAs Involved in Resistance to Sunitinib in Renal Cell Carcinoma Cells.
        Noriya Yamaguchi; Mitsuhiko Osaki; Kunishige Onuma; Tetsuya Yumioka; Hideto Iwamoto; Takehiro Sejima; Hiroyuki Kugoh; Atsushi Takenaka; Futoshi Okada
        Anticancer research, Jun. 2017
      • Design, synthesis, and biological evaluation of a highly water-soluble psoralen-based photosensitizer.
        Yoshiyuki Uruma; Takuya Nonomura; Priscilla Yoong Mei Yen; Marie Edatani; Ryotaro Yamamoto; Kunishige Onuma; Futoshi Okada
        Bioorganic & medicinal chemistry, 15 Apr. 2017
      • Amigo2-upregulation in Tumour Cells Facilitates Their Attachment to Liver Endothelial Cells Resulting in Liver Metastases.
        Yusuke Kanda; Mitsuhiko Osaki; Kunishige Onuma; Ayana Sonoda; Masanobu Kobayashi; Junichi Hamada; Garth L Nicolson; Takahiro Ochiya; Futoshi Okada
        Scientific reports, 08 Mar. 2017
      • Fermented Brown Rice and Rice Bran with Aspergillus oryzae (FBRA) Prevents Inflammation-Related Carcinogenesis in Mice, through Inhibition of Inflammatory Cell Infiltration.
        Kunishige Onuma; Yusuke Kanda; Saori Suzuki Ikeda; Ryuta Sakaki; Takuya Nonomura; Masanobu Kobayashi; Mitsuhiko Osaki; Masataka Shikanai; Hiroshi Kobayashi; Futoshi Okada
        Nutrients, 08 Dec. 2015
      • Fascin regulates chronic inflammation-related human colon carcinogenesis by inhibiting cell anoikis.
        Yusuke Kanda; Tokuichi Kawaguchi; Yasuhiro Kuramitsu; Takao Kitagawa; Tokushige Kobayashi; Norihiko Takahashi; Hiroshi Tazawa; Hasem Habelhah; Jun-Ichi Hamada; Masanobu Kobayashi; Mio Hirahata; Kunishige Onuma; Mitsuhiko Osaki; Kazuyuki Nakamura; Tomoyuki Kitagawa; Masuo Hosokawa; Futoshi Okada
        Proteomics, May 2014
      • Genetic reconstitution of tumorigenesis in primary intestinal cells.
        Kunishige Onuma; Masako Ochiai; Kaoru Orihashi; Mami Takahashi; Toshio Imai; Hitoshi Nakagama; Yoshitaka Hippo
        Proceedings of the National Academy of Sciences of the United States of America, 02 Jul. 2013
      • Development of a quantitative bioassay to assess preventive compounds against inflammation-based carcinogenesis.
        Kunishige Onuma; Yuka Suenaga; Ryuta Sakaki; Satoshi Yoshitome; Yu Sato; Satomi Ogawara; Saori Suzuki; Yasuhiro Kuramitsu; Hidekatsu Yokoyama; Akira Murakami; Junichi Hamada; Garth L Nicolson; Masanobu Kobayashi; Junichi Fujii; Futoshi Okada
        Nitric oxide : biology and chemistry, 01 Aug. 2011
      • Loss of adiponectin promotes intestinal carcinogenesis in Min and wild-type mice.
        Michihiro Mutoh; Naoya Teraoka; Shinji Takasu; Mami Takahashi; Kunishige Onuma; Masafumi Yamamoto; Naoto Kubota; Takamoto Iseki; Takashi Kadowaki; Takashi Sugimura; Keiji Wakabayashi
        Gastroenterology, Jun. 2011
      • Nano-scaled particles of titanium dioxide convert benign mouse fibrosarcoma cells into aggressive tumor cells.
        Kunishige Onuma; Yu Sato; Satomi Ogawara; Nobuyuki Shirasawa; Masanobu Kobayashi; Jun Yoshitake; Tetsuhiko Yoshimura; Masaaki Iigo; Junichi Fujii; Futoshi Okada
        The American journal of pathology, Nov. 2009
      • Elevated oxidative stress in erythrocytes due to a SOD1 deficiency causes anaemia and triggers autoantibody production.
        Yoshihito Iuchi; Futoshi Okada; Kunishige Onuma; Tadashi Onoda; Hironobu Asao; Masanobu Kobayashi; Junichi Fujii
        The Biochemical journal, 01 Mar. 2007
      • Deterioration of ischemia/reperfusion-induced acute renal failure in SOD1-deficient mice.
        Takuya Yamanobe; Futoshi Okada; Yoshihito Iuchi; Kunishige Onuma; Yoshihiko Tomita; Junichi Fujii
        Free radical research, Feb. 2007
      • Oxidative stress in erythrocytes; A cause for anemia and autoimmune response
        Y. Iuchi; F. Okada; K. Onuma; M. Kobayashi; J. Fujii
        PROCEEDINGS OF THE 3RD BIENNIAL MEETING OF THE SOCIETY FOR FREE RADICAL RESEARCH - ASIA & 6TH ANNUAL MEETING OF THE SOCIETY FOR FREE RADICAL RESEARCH - INDIA, 2007, Peer-reviewed
      • The role of nicotinamide adenine dinucleotide phosphate oxidase-derived reactive oxygen species in the acquisition of metastatic ability of tumor cells.
        Futoshi Okada; Masanobu Kobayashi; Hiroki Tanaka; Tokushige Kobayashi; Hiroshi Tazawa; Yoshihito Iuchi; Kunishige Onuma; Masuo Hosokawa; Mary C Dinauer; Nicholas H Hunt
        The American journal of pathology, Jul. 2006
      • Prevention of inflammation-mediated acquisition of metastatic properties of benign mouse fibrosarcoma cells by administration of an orally available superoxide dismutase
        F. Okada; H. Shionoya; M. Kobayashi; T. Kobayashi; H. Tazawa; K. Onuma; Y. Iuchi; N. Matsubara; T. Ijichi; B. Dugas; M. Hosokawa
        British Journal of Cancer, 27 Mar. 2006, Peer-reviewed

      Misc.

      • 大腸がん転移におけるがん細胞集団の極性転換の役割
        小沼 邦重; 近藤 純平; 井上 正宏
        日本癌学会総会記事, Sep. 2021
      • Heterogenous chemosensitivity of a panel of organoid lines derived from small cell neuroendocrine carcinoma of the uterine cervix (Mar, 10.1007/s13577-021-00511-5, 2021)
        Mie Tanaka; Jumpei Kondo; Kensuke Kaneko; Hiroko Endo; Kunishige Onuma; Roberto Coppo; Masamune Masuda; Shoji Kamiura; Kiyoshi Yoshino; Yutaka Ueda; Hideaki Kakeya; Tadashi Kimura; Masahiro Inoue
        HUMAN CELL, May 2021
      • 大腸がん転移におけるがん細胞集団の極性転換の役割
        小沼 邦重; 近藤 純平; 井上 正宏
        日本癌学会総会記事, Oct. 2020
      • Micropapillary carcinoma病態における極性転換とその分子機構(Molecular mechanism of polarity switching in micropapillary carcinoma)
        小沼 邦重; 近藤 純平; 井上 正宏
        日本癌学会総会記事, Sep. 2019
      • 血管内皮細胞に発現しているMTA1はS100A4を介する事で新たな腫瘍血管新生の阻害標的になりうる
        石川瑞穂; 尾崎充彦; 尾崎充彦; 山岸誠; 小沼邦重; 井藤久雄; 井藤久雄; 岡田太; 岡田太; 遠藤英也
        日本病理学会会誌, 15 Apr. 2019
      • Silencing of MTA1 in endothelial cells induced anti-tumor effect by inhibiting angiogenesis via downregulation of S100A4
        Mizuho Ishikawa; Mitsuhiko Osaki; Makoto Yamagishi; Kunishige Onuma; Hisao Ito; Futoshi Okada; Hideya Endo
        CANCER SCIENCE, Dec. 2018
      • 血管内皮細胞におけるMTA1発現の抑制はS100A4発現抑制を介した血管新生阻害による抗腫瘍効果を引き起こす(Silencing of MTA1 in endothelial cells induced anti-tumor effect by inhibiting angiogenesis via downregulation of S100A4)
        石川 瑞穂; 尾崎 充彦; 山岸 誠; 小沼 邦重; 井藤 久雄; 岡田 太; 遠藤 英也
        日本癌学会総会記事, Sep. 2018
      • xCT遺伝子欠損マウスメラノーマ細胞の細胞死解析と腫瘍増殖能の評価
        佐藤茉美; 鈴木亜実; 久住亮介; 小沼邦重; 尾崎充彦; 岡田太; CONRAD Marcus; 坂内四郎; 佐藤英世
        日本生化学会大会(Web), Sep. 2018
      • 血管内皮細胞におけるMTA1発現は血管新生阻害の標的分子となりうる(MTA1 expressed in endothelial cells is a candidate target molecule for inhibiting angiogenesis)
        石川 瑞穂; 尾崎 充彦; 山岸 誠; 小沼 邦重; 井藤 久雄; 岡田 太; 遠藤 英也
        日本病理学会会誌, Apr. 2018
      • 血管内皮細胞におけるMTA1発現は血管新生阻害の標的分子となりうる(MTA1 expressed in endothelial cells is a candidate target molecule for inhibiting angiogenesis)
        石川 瑞穂; 尾崎 充彦; 山岸 誠; 小沼 邦重; 井藤 久雄; 岡田 太; 遠藤 英也
        日本病理学会会誌, Apr. 2018
      • Silencing of MTA1 in endothelial cells induced tumor regression by inhibiting angiogenesis via downregulation of S100A4
        Mizuho Ishikawa; Mitsuhiko Osaki; Makoto Yamagishi; Kunishige Onuma; Hisao Ito; Futoshi Okada; Hideya Endo
        CANCER SCIENCE, Jan. 2018
      • Amigo2 determines liver metastasis through selective adhesion to liver endothelial cells
        Yusuke Kanda; Kunishige Onuma; Ayana Sonoda; Junichi Hamada; Masanobu Kobayashi; Mitsuhiko Osaki; Takahiro Ochiya; Futoshi Okada
        CANCER SCIENCE, Jan. 2018
      • Downregulation of miR-194-5p involved in sunitinib resistance in human renal cell carcinoma cell
        Tetsuya Yumioka; Mitsuhiko Osaka; Noriya Yamaguchi; Yusuke Kanda; Hideto Iwamoto; Kunishige Onuma; Shuichi Morizane; Masashi Honda; Futoshi Okada; Atsushi Takenaka
        CANCER SCIENCE, Jan. 2018
      • ヒト由来骨肉腫細胞の浸潤能とグルタチオン合成制御系との関連性
        久住 亮介; 鈴木 悠; 小沼 邦重; 尾崎 充彦; 坂内 四郎; 岡田 太; 佐藤 英世
        生命科学系学会合同年次大会, Dec. 2017
      • シスチン/グルタミン酸輸送体は細胞内グルタチオンの維持を通してがん細胞の遊走・浸潤・転移に寄与する
        佐藤茉美; 鈴木亜実; 小沼邦重; 尾崎充彦; 坂内四郎; 岡田太; 佐藤英世
        日本生化学会大会(Web), Dec. 2017
      • Sunitinib耐性腎細胞癌細胞においてmiR-194-5pはリソソーム関連膜タンパク質2標的化により細胞増殖を抑制した(miR-194-5p suppressed cell proliferation by targeting lysosome associated membrane protein 2 in sunitinib-resistant renal cell caricinoma cells)
        弓岡 徹也; 尾崎 充彦; 山口 徳也; 小沼 邦重; 岩本 秀人; 森實 修一; 本田 正史; 岡田 太; 武中 篤
        西日本泌尿器科, Oct. 2017
      • miR-194-5pの抑制はヒト腎癌細胞株におけるスニチニブ抵抗性に関与する
        弓岡 徹也; 尾崎 充彦; 山口 徳也; 神田 裕介; 岩本 秀人; 小沼 邦重; 森實 修一; 本田 正史; 岡田 太; 武中 篤
        日本癌学会総会記事, Sep. 2017
      • 血管内皮細胞におけるMTA1の抑制はS100A4抑制を介した血管新生阻害による腫瘍退縮を引き起こす
        石川 瑞穂; 尾崎 充彦; 山岸 誠; 小沼 邦重; 井藤 久雄; 岡田 太; 遠藤 英也
        日本癌学会総会記事, Sep. 2017
      • 肝転移を決定するAmigo2
        神田 裕介; 小沼 邦重; 園田 彩奈; 浜田 淳一; 小林 正伸; 尾崎 充彦; 落谷 孝広; 岡田 太
        日本癌学会総会記事, Sep. 2017
      • IDENTIFICATION OF MICRORNA REGULATING SUNITINIB RESISTANCE IN RENAL CELL CARCINOMA CELLS
        Noriya Yamaguchi; Tetsuya Yumioka; Kunishige Onuma; Hideto Iwamoto; Toshihiko Masago; Shuichi Morizane; Masashi Honda; Mitsuhiko Osaki; Futoshi Okada; Atsushi Takenaka
        JOURNAL OF UROLOGY, Apr. 2017
      • 肝転移に必要な新規分子の同定
        神田裕介; 小沼邦重; 園田彩奈; 尾崎充彦; 岡田太
        日本病理学会会誌, 24 Mar. 2017
      • 悪性度の異なる腫瘍細胞間の相互作用の解析
        香川恵理華; 神田裕介; 佐々木諒; 小沼邦重; 尾崎充彦; 尾崎充彦; 岡田太; 岡田太
        日本病理学会会誌, 24 Mar. 2017
      • 腎細胞癌細胞におけるsunitinib耐性に関与するmicroRNAの同定(Identification of microRNA involved in sunitinib resistance of renal cell carcinoma cells)
        山口 徳也; 弓岡 徹也; 小沼 邦重; 岩本 秀人; 尾崎 充彦; 岡田 太; 武中 篤
        西日本泌尿器科, Oct. 2016
      • 血管内皮細胞におけるMTA1の抑制はS100A4抑制を介した血管新生阻害による腫瘍退縮を引き起こす
        石川 瑞穂; 尾崎 充彦; 山岸 誠; 小沼 邦重; 井藤 久雄; 岡田 太; 遠藤 英也
        日本癌学会総会記事, Oct. 2016
      • 発酵玄米による炎症発がんの抑制
        小沼 邦重; 神田 裕介; 野々村 拓也; 小林 正伸; 尾崎 充彦; 鹿内 正孝; 小林 博; 岡田 太
        日本生化学会大会プログラム・講演要旨集, Sep. 2016
      • 肝転移を規定する分子の同定を目指した細胞株の樹立
        神田 裕介; 小沼 邦重; 平畑 美緒; 佐々木 諒; 尾崎 充彦; 岡田 太
        日本癌学会総会記事, Oct. 2015
      • miR‐143の標的遺伝子であるPAI‐1はヒト骨肉腫細胞の肺転移に関与する
        平畑美緒; 尾崎充彦; 神田裕介; 小沼邦重; 井藤久雄; 岡田太
        日本病理学会会誌, 23 Mar. 2015
      • 転移先臓器指向性を規定する分子群探索のための細胞株樹立
        神田裕介; 平畑美緒; 小沼邦重; 尾崎充彦; 岡田太
        日本病理学会会誌, 23 Mar. 2015
      • 糖質を機能素子とする光感受性物質配糖ソラレンの開発
        粳間由幸; 野々村拓也; 内藤星佳; 小沼邦重; 岡田太
        日本薬学会年会要旨集(CD-ROM), Mar. 2015
      • ヒト大腸腺腫細胞の大腸癌細胞への進展における慢性炎症由来一酸化窒素の証明とfascinの同定(Nitric oxide from chronic inflammation and fascin in conversion of human colonic adenoma cells into adenocarcinoma cells)
        神田 裕介; 河口 徳一; 田澤 大; 平畑 美緒; 小沼 邦重; 北川 知行; 尾崎 充彦; 岡田 太
        日本癌学会総会記事, Sep. 2014
      • miR‐143の標的遺伝子であるPAI‐1は骨肉腫細胞の肺転移に関与する
        平畑美緒; 伊藤真保; 神田裕介; 小沼邦重; 井藤久雄; 岡田太; 尾崎充彦
        日本病理学会会誌, 26 Mar. 2014
      • APC不活性化による腸管上皮細胞の形質転換におけるSTAT3活性化の関与(STAT3 Activation Underlies Transformation of Primary Intestinal Epithelial Cells by APC Suppression)
        折橋 郁; 小沼 邦重; 松浦 哲也; 落合 雅子; 今井 俊夫; 中釜 斉; 筆宝 義隆
        日本癌学会総会記事, Oct. 2013
      • 発癌環境としての低酸素再酸素化由来の活性酸素・活性窒素(Hypoxia-reoxygenation and its-derived reactive nitrogen oxides as a carcinogenic factor)
        神田 裕介; 坂木 隆太; 小沼 邦重; 浜田 淳一; 小林 正伸; 尾崎 充彦; 井藤 久雄; 岡田 太
        日本癌学会総会記事, Oct. 2013
      • 炎症発癌を遮断する阻害化合物探索
        池田多津世; 末永裕佳; 神田裕介; 小沼邦重; 尾崎充彦; 岡田太
        日本病理学会会誌, 26 Apr. 2013
      • in vitro再構成系におけるK-ras活性化によるApc依存的腸管発がんの促進(K-ras Activation Accelerates Apc-dependent Intestinal Tumorigenesis Reconstituted In Vitro)
        筆宝 義隆; 小沼 邦重; 落合 雅子; 中釜 斉
        日本癌学会総会記事, Aug. 2012
      • マウス正常腸管細胞を用いたin vitro化学発がんモデルの検討(Reconstituting Chemical Carcinogenesis with Murine Intestinal Epithelial Cells in 3-D Culture)
        落合 雅子; 小沼 邦重; 筆宝 義隆; 中釜 斉
        日本癌学会総会記事, Aug. 2012
      • マウス腸管発がん再構成系を用いて作製した腫瘍の解析(Characterization of Tumors Generated by Lentivirus-based Direct Transformation of Primary Murine Intestinal Cells)
        小沼 邦重; 筆宝 義隆; 落合 雅子; 中釜 斉
        日本癌学会総会記事, Aug. 2012
      • In vitro発がん再構築系を用いた発がん過程における炎症の役割(Dissecting potential roles of inflammation in carcinogenesis with in vitro reconstitution model)
        小沼 邦重; 土橋 祥子; 落合 雅子; 中釜 斉; 筆宝 義隆
        日本癌学会総会記事, Sep. 2011
      • 腸管発がんにおける遺伝子間相互作用を再構成するためのin vitro培養系の開発(Development of in vitro system to reconstitute genetic interactions in intestinal carcinogenesis)
        落合 雅子; 小沼 邦重; 土橋 祥子; 中釜 斉; 筆宝 義隆
        日本癌学会総会記事, Sep. 2011
      • 肥満KK-AyマウスにおけるアンジオテンシンII受容体阻害薬の大腸発がん抑制効果(Impacts of an Angiotensin II Receptor Blocker on Colon Carcinogenesis in Obese KK-A' Mice)
        高須 伸二; 武藤 倫弘; 小沼 邦重; 上野 俊也; 若林 敬二; 中釜 斉
        日本癌学会総会記事, Sep. 2011
      • 炎症発癌を標的とした予防化合物の定量的検出系の開発(Development of a Quantitative Bioassay to Assess Preventive Compounds against Inflammation-based C arcinogenesis)
        末永 裕佳; 坂木 隆太; 小沼 邦重; 村上 明; 田中 宏樹; 浜田 淳一; 小林 正伸; 藤井 順逸; 岡田 太
        日本癌学会総会記事, Sep. 2011
      • Adiponectin knockout enhances intestinal carcinogenesis in Min and wild-type mice
        Michihiro Mutoh; Naoya Teraoka; Shinji Takasu; Mami Takahashi; Kunishige Onuma; Naoto Kubota; Takashi Kadowaki; Keiji Wakabayashi; Hitoshi Nakagama
        CANCER RESEARCH, Apr. 2011
      • 酸化チタンナノ粒子による発癌過程促進の可能性
        小沼邦重; 白澤信行; 藤井順逸; 岡田太
        Yamagata Medical Journal, 13 Aug. 2010
      • 炎症発癌に対する予防化合物の同定(Identification of the compounds preventive against inflammation-related carcinogenesis)
        小沼 邦重; 藤井 順逸; 小林 正伸; 岡田 太
        日本癌学会総会記事, Aug. 2010
      • Angptl3ホモ欠損マウスにおける腸ポリープ生成亢進と炎症状態の惹起(Increased intestinal polyp development in Angptl3 (-/-) Min mice with evoked inflammatory status)
        小宮 雅美; 武藤 倫弘; 高須 伸二; 小沼 邦重; 寺岡 直哉; 上野 俊也; 高橋 真美; 杉村 隆; 若林 敬二
        日本癌学会総会記事, Aug. 2010
      • 肥満KK-AyマウスにおけるアンギオテンシンII受容体拮抗薬の大腸発がんに与える影響(Effects of an angiotensin II receptor blocker on colon carcinogenesis in obese KK-Ay mouse)
        高須 伸二; 武藤 倫弘; 寺岡 直哉; 上野 俊也; 小沼 邦重; 高橋 真美; 堀 美香; 杉村 隆; 若林 敬二
        日本癌学会総会記事, Aug. 2010
      • 柑橘類クマリン誘導体とウコン抽出物によるマウス退縮型線維肉腫細胞の炎症に起因した発癌予防
        小沼邦重; 佐藤優; 小河原里美; 藤井順逸; 岡田太
        Yamagata Medical Journal, 15 Aug. 2009
      • 非遺伝毒性発癌物質の短期かつ高精度な検出系の開発
        佐藤優; 小沼邦重; 小河原里美; 藤井順逸; 岡田太
        Yamagata Medical Journal, 15 Aug. 2009
      • 低酸素・再酸素化に由来する活性酸素 活性酸化窒素の発癌に果たす役割
        小河原里美; 佐藤優; 小沼邦重; 藤井順逸; 岡田太
        Yamagata Medical Journal, 15 Aug. 2009
      • 酸化チタンナノ粒子による良性腫瘍細胞の悪性化進展(Progression of Benign Tumor Cells into Malignant Ones by Nano-scaled Particles of Titanium Dioxide)
        小沼 邦重; 吉武 淳; 飯郷 正明; 小林 正伸; 藤井 順逸; 岡田 太
        日本癌学会総会記事, Aug. 2009
      • Aurapteneあるいはturmeroneによるマウス退縮型線維肉腫細胞の炎症発癌予防(Prevention of inflammation-based carcinogenesis of mouse regressive fibrosarcoma cells by auraptene or turmerone)
        小沼 邦重; 小林 正伸; 横山 秀克; 村上 明; 藤井 順逸; 岡田 太
        日本癌学会総会記事, Sep. 2008
      • 酸化チタンナノ粒子による発癌促進作用
        佐藤優; 小沼邦重; 小河原里美; 藤井順逸; 岡田太
        Yamagata Medical Journal, 15 Aug. 2008
      • 炎症を介したマウス退縮型線維肉腫細胞の発癌・悪性化進展の経口SOD剤による抑制
        小沼邦重; 佐藤優; 小河原里美; 塩野谷博; 松原範宜; 藤井順逸; 岡田太
        Yamagata Medical Journal, 15 Aug. 2008
      • Glycosylphosphatidylinositolアンカータンパク質,GPI‐80の腫瘍増殖および癌転移に占める役割
        小沼邦重; 仙道富士郎; 藤井順逸; 岡田太
        Yamagata Medical Journal, 15 Aug. 2007
      • 良性腫瘍の炎症介在性の転移能獲得における反応性一酸化窒素の関与(Involvement of reactive nitrogen oxides for acquisition of metastatic properties of benign tumors through inflammation)
        岡田 太; 田澤 大; 小沼 邦重; 小林 正伸; 細川 眞澄男
        日本癌学会総会記事, Aug. 2007
      • スーパーオキシドジスムターゼの経口投与による炎症介在性腫瘍進行の予防(Prevention of inflammation-mediated tumor progression by orally available superoxide dismutase)
        小沼 邦重; 塩野谷 博; 田澤 大; 松原 範宜; 小林 正伸; 細川 眞澄男; 岡田 太
        日本癌学会総会記事, Aug. 2007
      • 発癌・悪性化要因としての炎症細胞由来活性酸素の証明
        岡田 太; 小沼 邦重; 田中 宏樹; 田澤 大; 小林 正伸; 細川 眞澄男
        日本癌学会総会記事, Sep. 2006
      • Glycosylphosphatidylinositolアンカータンパク質、GPI-80の腫瘍増殖および癌転移に占める役割
        小沼 邦重; 小林 正伸; 仙道 富士郎; 藤井 順逸; 岡田 太
        日本癌学会総会記事, Sep. 2006
      • SOD1欠損により腎臓の虚血再灌流傷害は悪化する
        山辺拓也; 岡田太; 井内良仁; 小沼邦重; 冨田善彦; 藤井順逸
        Yamagata Medical Journal, 15 Aug. 2006
      • 赤血球への酸化ストレスは貧血と自己抗体の生成をもたらす
        井内 良仁; 岡田 太; 小沼 邦重; 小林 正伸; 藤井 順逸
        生化学, Aug. 2006
      • Autoimmunity triggered by accelerated erythrocyte ageing
        Y. Iuchi; F. Okada; K. Onuma; M. Kobayashi; J. Fujii
        FREE RADICAL RESEARCH, 2006
      • Elevated oxidative stress due to SOD1-deficiency causes generation of autoantibody against erythrocytes in mice
        J. Fujii; Y. Iuchi; F. Okada; K. Onuma; M. Kobayashi
        FREE RADICAL RESEARCH, 2006

      External funds: Kakenhi

      • Micropapillary carcinomaの極性転換を標的とした治療戦略
        Grant-in-Aid for Scientific Research (C)
        Basic Section 53010:Gastroenterology-related
        Kyoto University
        小沼 邦重
        From 01 Apr. 2023, To 31 Mar. 2027, Granted
        がん細胞集団の極性転換;micropapillary carcinoma;がん細胞集団の薬剤感受性;大腸がんオルガノイド;がんの極性転換;オルガノイド
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K07395/
      • 新しい細胞集塊薬剤浸透性評価モデルの開発
        Grant-in-Aid for Scientific Research (C)
        Basic Section 50010:Tumor biology-related
        Tokyo Women's Medical University
        田中 正太郎
        From 01 Apr. 2023, To 31 Mar. 2026, Granted
        スフェロイド;ライブイメージング;薬剤探索研究;ハイスループットスクリーニング;薬剤浸透評価;オルガノイド
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K06659/
      • Mechanisms of the immune evasion through polarity switching of the colorectal cancer clusters
        Grant-in-Aid for Challenging Research (Exploratory)
        Medium-sized Section 50:Oncology and related fields
        Kyoto University
        Masahiro INOUE
        From 30 Jun. 2022, To 31 Mar. 2024, Project Closed
        大腸癌;オルガノイド;免疫回避;極性;micropapillary;治療戦略;細胞塊
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K19456/
      • The mechanism of polarity switching in the cluster of human colorectal adenocarcinoma during the process of metastasis
        Grant-in-Aid for Scientific Research (C)
        Basic Section 53010:Gastroenterology-related
        Kyoto University
        Onuma Kunishige
        From 01 Apr. 2020, To 31 Mar. 2023, Project Closed
        がん細胞集団の極性転換;がん細胞集団の転移;大腸癌オルガノイド;血管内皮との接着;活性酸素;micropapillary carcinoma;薬剤感受性と極性転換;極性転換と転移;がん細胞集団の薬剤感受性;Micropapillary carcinoma;大腸がんオルガノイド;オルガノイド;癌三次元培養法;細胞集団細胞極性;癌細胞集団の転移能アッセイ
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K08286/
      • Development of Deep Cellular Cancer Therapy Using Photosensitizer-Encapsulated Upconversion Particles
        Grant-in-Aid for Scientific Research (C)
        Basic Section 90120:Biomaterials-related
        Yonago National College of Technology
        YOSHIYUKI URUMA
        From 01 Apr. 2019, To 31 Mar. 2023, Project Closed
        光増感剤;一重項活性酸素;低酸素;光線力学;光線力学療法;近赤外;アップコンバージョン;ナノ粒子;細胞深層部;近赤外線
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K12813/
      • Studies on inflammation-induced intestinal bowel carcinogenesis by using organoids
        Grant-in-Aid for Young Scientists (B)
        Tottori University
        kunishige onuma
        From 01 Apr. 2014, To 31 Mar. 2016, Project Closed
        オルガノイド;腸管発癌;炎症
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26860264/
      • Mechanism of inflammation-accelerate colorectal carcinogenesis by reconstitutive model
        Grant-in-Aid for Young Scientists (B)
        Tottori University
        Kunishige ONUMA
        From 01 Apr. 2012, To 31 Mar. 2014, Project Closed
        炎症;オルガノイド;腸管発癌;発癌;癌遺伝子;癌抑制遺伝子
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24700959/
      • Establishment of photodynamic therapy for deep cell tumors using the up-conversion method
        Grant-in-Aid for Scientific Research (C)
        Basic Section 90120:Biomaterials-related
        Yonago National College of Technology
        粳間 由幸
        From 01 Apr. 2024, To 31 Mar. 2027, Granted
        光線力学療法;近赤外;アップコンバージョン;ナノ粒子
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K15761/

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