Basic Information

Affiliated programs (koza)

• Graduate School of Biostudies, 統合生命科学専攻　老化感染制御学, 助教

Email Address

• Email Address

  okahata.misaki.8wkyoto-u.ac.jp

Professional Memberships

• From 2020, To Present

  日本生物物理学会
• From 2015, To Present

  日本分子生物学会
• From 2015, To Present

  日本比較生理化学学会
• From 2014, To Present

  日本遺伝学会
• From 2014, To Present

  日本神経科学学会

Academic Degree

• 31 Mar. 2020

  甲南大学博士（理学）
• 31 Mar. 2017

  甲南大学修士（理学）

Academic Resume (Undergraduate School/Majors)

• 甲南大学, 理工学部生物学科, 卒業

Research History

• From Apr. 2026, To Present

  Kyoto University, 医生物学研究所, 助教
• From Oct. 2023, To Mar. 2026

  大阪大学生命機能研究科, 日本学術振興会特別研究員RPD
• From Apr. 2020, To Jul. 2023

  甲南大学自然科学研究科, 日本学術振興会特別研究員PD
• From Apr. 2017, To Mar. 2020

  甲南大学自然科学研究科, 日本学術振興会特別研究員DC1

ID,URL

• J-Global ID

  202001007391322407

• Researcher number

  20880561

researchmap URL

• https://researchmap.jp/mokahata

Research

Research Areas

• Life sciences, Neuroscience - general
• Life sciences, Genetics

Papers

• Natural variations in small RNA origin loci generate circuit diversity underlying temperature acclimation in Caenorhabditis elegans.

  Misaki Okahata; Taichiro Iki; Sawako Yoshina; Yohei Minakuchi; Yukina Mori; Natsumi Sawada; Toru Miura; Toshie Kai; Atsushi Toyoda; Shohei Mitani; Akane Ohta; Atsushi Kuhara

  Proceedings of the National Academy of Sciences of the United States of America, 26 May 2026, Peer-reviewed, Lead author

  Access this paper :

  
• Screening for cold tolerance genes in C. elegans, whose expressions are affected by anticancer drugs camptothecin and leptomycin B

  Misaki Okahata; Natsumi Sawada; Kenji Nakao; Akane Ohta; Atsushi Kuhara

  Scientific Reports, 05 Mar. 2024, Peer-reviewed, Lead author

  
• Cold Tolerance in the Nematode Caenorhabditis elegans.

  Atsushi Kuhara; Natsune Takagaki; Misaki Okahata; Akane Ohta

  Advances in experimental medicine and biology, 2024

  
• Anticancer drugs affect temperature signaling and epigenetic factors in the cold tolerance of Caenorhabditis elegans

  Misaki Okahata; Natsumi Sawada; Kenji Nakao; Akane Ohta; Atsushi Kuhara

  Research Square, 22 Nov. 2022

  
• Molecular physiology regulating cold tolerance and acclimation of Caenorhabditis elegans

  Misaki OKAHATA; Haruka MOTOMURA; Akane OHTA; Atsushi KUHARA

  Proceedings of the Japan Academy, Series B, 11 Mar. 2022, Peer-reviewed, Lead author

  
• Cold acclimation via the KQT-2 potassium channel is modulated by oxygen in Caenorhabditis elegans.

  Misaki Okahata; Aguan D Wei; Akane Ohta; Atsushi Kuhara

  Science advances, Feb. 2019, Peer-reviewed, Lead author

  
• Molecular and Cellular Network Systems Underlying Cold Tolerance of Caenorhabditis elegans

  Ohnishi K; Takagaki N; Okahata M; Fujita M; Ohta A; Kuhara A

  Cryobiology and Cryotechnology, 2018, Peer-reviewed

  
• Natural variations of cold tolerance and temperature acclimation in Caenorhabditis elegans.

  Misaki Okahata; Akane Ohta; Hitomi Mizutani; Yohei Minakuchi; Atsushi Toyoda; Atsushi Kuhara

  Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, Jun. 2016, Peer-reviewed, Lead author

  
• Cold tolerance assay for studying cultivation-temperature-dependent cold habituation in C. elegans

  Ujisawa T; Ohta, A; Okahata M; Sonoda S; Kuhara, A

  Protocol Exchange, 2014

  

Misc.

• Imaging and manipulation of temperature response of nerve cells in brain-gut interaction underlying cold tolerance

  福本晃久; 岡畑美咲; 本村晴佳; 太田茜; 久原篤

  アグリバイオ, Jun. 2021, Lead author

  
• Neural Circuit Model for Sensory Information Integration in C. elegans

  岡畑美咲; 久原 篤

  生物物理, 28 May 2021, Peer-reviewed, Lead author

  
• 光遺伝学を用いたシングル細胞解析による温度応答の解析

  岡畑美咲; 本村晴佳; 太田茜 久原篤

  月刊「細胞」特集 単一細胞レベル解析の新技術, Oct. 2020, Lead author

  
• 線虫 Caenorhabditis elegansの低温馴化における温度感覚は酸素濃度の影響を受ける

  岡畑 美咲; 太田 茜; 久原 篤

  比較生理生化学, Aug. 2020, Peer-reviewed, Lead author

  
• 線虫 C. elegans における酸素濃度依存的な温度受容に関わる神経回路の解析

  岡畑美咲

  若手研究者が語る２１世紀の遺伝学(XV) 日本遺伝学会第90回大会 Best paper賞 Genes ＆ Genetic Systems, 2019, Lead author

  
• International C. e!egans meetingに参加して

  岡畑美咲

  比較生理生化学, 2017, Lead author

  
• Genetic analysis of natural variation and potassium channel in cold acclimation

  Misaki Okahata; Akane Ohta; Yohei Minakuchi; Atsushi Toyoda; Atsushi Kuhara

  GENES & GENETIC SYSTEMS, Dec. 2016, Lead author

  
• Natural variation of genes for temperature responses and memory in C-elegans

  Misaki Okahata; Akane Ohta; Atsushi Kuhara

  GENES & GENETIC SYSTEMS, Dec. 2014, Lead author

  

Presentations

• 多様化したsmall RNAがC. elegansにおける環境適応神経回路の多様性を生み出す

  岡畑 美咲; 井木 太一郎; 吉名 佐和子; 水口 洋平; 三谷 昌平; 甲斐 歳惠; 三浦 徹; 豊田 敦; 太田 茜; 久原 篤

  neuro2026, 30 Jul. 2026

  
• 母として研究者として生きていくために

  岡畑美咲

  育志賞受賞者交流会, 12 Nov. 2024, Invited

  
• Neural circuit regulating the diversity of cold acclimation in C. elegans

  岡畑美咲; 吉名佐和子; 水口洋平; Aguan D. Wei; 豊田敦; 三谷昌平; 三浦徹; 太田茜; 久原篤

  第５９回日本生物物理学会年会, Nov. 2021

  
• 線虫C. elegansの低温馴化多様性を生み出す酸素と温度の神経回路の解析

  岡畑美咲; 吉名佐和子; 水口洋平; Aguan D. Wei; 豊田敦; 三谷昌平; 三浦徹; 太田茜; 久原篤

  日本遺伝学会, Sep. 2021

  
• The model of neural circuit integrating different sensory information in C. elegans

  Misaki Okahata; Aguan D. Wei; Akane Ohta; Atsushi Kuhata

  第58回日本生物物理学会年会, 16 Sep. 2020, Invited

  
• Cold acclimation via KCNQ potassium channel is modulated by oxygen in simple neural circuit

  Misaki OKAHATA; Aguan D. Wei; Akane OHTA; Atsushi KUHARA

  Federation of European Neuroscience Societies (FENS) 2020

  
• Oxygen affects thermo-sensory neuron activity in cold acclimation of C. elegans

  Misaki Okahata、Aguan D. Wei、Akane Ohta、Atsushi Kuhara

  日本遺伝学会第91回大会, Sep. 2019, Invited

  
• 線虫C. elegansにおける酸素濃度依存的な温度受容に関わる神経回路の解析

  岡畑美咲、Aguan D. Wei、太田茜、久原篤

  日本遺伝学会, Sep. 2018

  
• Analysis of neural circuit for cold acclimation depending on oxygen concentration

  Okahata-Yamasaki M., Aguan D. Wei, Ohta A., Kuhara A.

  8th Asia-Pacific C. elegans meeting, Jul. 2018

  
• Natural variations of cold acclimation and analysis of KQT potassium channel in cold acclimation

  Okahata M., Ohta A., Minakuchi Y., Toyoda A., Kuhara A.

  21th C. elegans International conference, Jun. 2017

  
• 温度馴化に関わる遺伝子多型とカリウムチャネルの解析

  岡畑美咲、太田茜、水口洋平、豊田敦、久原篤

  日本遺伝学会, Sep. 2016

  
• Genetic analysis of natural variants showing various cold acclimation

  Okahata M., Ohta A., Minakuchi Y., Toyoda A., Kuhara A.

  CeNeuro2016, Jul. 2016

  
• Genetic analysis of natural variations for cold habituation in C. elegans

  Okahata M., Ohta A., Minakuchi Y., Toyoda A., Kuhara A.

  20th International C. elegans meeting, Jun. 2015

  
• 線虫C. elegansにおける温度応答と記憶の多様性に関わる遺伝子多型

  日本遺伝学会, Sep. 2014

  
• Natural variation modifies temperature responses and memory

  Okahata M., Furukawa S, Ohta A., Kuhara A.

  6th Asia-Pacific C. elegans Meeting, Jul. 2014

  

External funds: Kakenhi

• ホヤ幼生の温度応答を制御する神経回路

  Grant-in-Aid for Research Activity Start-up

  0702:Biology at cellular to organismal levels, and related fields

  Kyoto University

  岡畑 美咲

  From 31 Jul. 2026, To 31 Mar. 2028, Granted

  カタユウレイボヤ;温度応答;光遺伝学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26K24916/
• HADH, involved in mitochondrial fatty acid metabolism, regulates temperature acclimation

  Grant-in-Aid for Early-Career Scientists

  Basic Section 44050:Animal physiological chemistry, physiology and behavioral biology-related

  Osaka University;Konan University

  Misaki Okahata

  From 01 Apr. 2021, To 31 Mar. 2024, Project Closed

  C. elegans;高温馴化;線虫;高温順化;hadh;ミトコンドリア;温度;3ヒドロキシアシルCoA脱水素酵素;ミトコンドリア分子;脂肪酸代謝;低温耐性

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K15141/