Lung regeneration, Lung injury and repair, single cell analysis, lung fibrosis, emphysema, lung remodeling, lung specific transgenic mice, animal models, COPD
Overview of the research
Using various kinds of lung disease models (COPD, lung fibrosis, ARDS and asthma etc.), lung regeneration models (alveolar and bronchial stem cells) and transgenic models (including conditional Tg, lung specific), we have been trying to show the mechanism of lung homeostasis for drug discovery. Our systematic approach using human sample, clinical data and results from in vivo study could bring us novel insights of science.
Research Interests
Lung regeneration, Lung injury and repair, single cell analysis, lung fibrosis, emphysema, lung remodeling, lung specific transgenic mice, animal models, COPD, Asthma, scRNA-seq
Research Areas
Life sciences, Laboratory animal science
Life sciences, Cell biology
Life sciences, Allergies and connective tissue disease
Life sciences, Respiratory medicine
Papers
Antigravity muscle density on computed tomography and health-related independence in normal weight patients with chronic obstructive pulmonary disease.
Stationary Oxygen Concentrator with Built-in Respiratory Rate Monitor: Clinical Validation of Its Efficacy in Patients with Interstitial Lung Disease and Chronic Obstructive Pulmonary Disease.
Phase angle measured by bioelectrical impedance analysis in patients with chronic obstructive pulmonary disease: Associations with physical inactivity and frailty.
Mucus plugging on computed tomography and the sputum microbiome in patients with asthma, chronic obstructive pulmonary disease, and asthma-COPD overlap.
Allergology international : official journal of the Japanese Society of Allergology, 15 Jul. 2024
Computed tomography mucus plugs and airway tree structure in patients with chronic obstructive pulmonary disease: Associations with airflow limitation, health-related independence and mortality.
Associations of fractional exhaled nitric oxide with airway dimension and mucus plugs on ultra-high-resolution computed tomography in former smokers and nonsmokers with asthma.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 23 Feb. 2024
Longitudinal changes in respiratory reactance in patients with COPD: associations with longitudinal change in air-trapping, exacerbations, and mortality.
Evaluation of respiratory rate monitoring performance using a home oxygen monitoring device among patients with interstitial lung disease and chronic obstructive pulmonary disease.
Associations of pulmonary and extrapulmonary computed tomographic manifestations with impaired physical activity in symptomatic patients with chronic obstructive pulmonary disease.
Physiological Impairments on Respiratory Oscillometry and Future Exacerbations in Chronic Obstructive Pulmonary Disease Patients without a History of Frequent Exacerbations.
Quantitative Assessment of Erector Spinae Muscles in Patients with Chronic Obstructive Pulmonary Disease. Novel Chest Computed Tomography-derived Index for Prognosis.
Exploratory analysis of a phase III trial of pirfenidone identifies a subpopulation of patients with idiopathic pulmonary fibrosis as benefiting from treatment
K Hamada; S Nagai; M Kitaichi; G Jin; M Shigematsu; T Nagao; A Sato; M Mishima
INTERNAL MEDICINE, Jan. 2003, Peer-reviewed
Misc.
Survival impact of treatment for chronic obstructive pulmonary disease in patients with advanced non-small cell lung cancer
H. Ajimizu; H. Ozasa; S. Sato; Y. Sakamori; T. Funazo; Y. Yasuda; T. Nomizo; T. Tsuji; H. Yoshida; Y. Yagi; H. Nagai; A. Sato; M. Tsuchiya; S. Muro; Y. Nagasaka; M. Mishima; Y. H. Kim
ANNALS OF ONCOLOGY, Oct. 2016
The Cluster Analysis Of Elastase-Induced Emphysema In Mice Using Micro-Computed Tomography (ct)
Y. Fuseya; A. Sato; S. Sato; K. Uemasu; K. Tanimura; K. Hasegawa; Y. Hamakawa; S. Muro; T. Hirai
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2017
Tiotropium And Olodaterol Attenuate Smoke-Induced Aalveolar Cell Inflammation In Mice
Y. Hamakawa; A. Sato; K. Uemasu; K. Hasegawa; S. Sato; M. P. Pieper; S. Muro
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2017
Role Of Ccaat/enhancer Binding Protein-alpha (c/ebpa) In Airway Epithelial Cells During Chronic Cigarette Smoke Exposure In Mice
K. Uemasu; A. Sato; K. Tanimura; K. Hasegawa; Y. Hamakawa; S. Sato; S. Muro
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2017
Alveolar Type 2 Cell Dynamics And Long-Term Effect Of Allogenic Alveolar Type 2 Cell Transplantation In Murine Bleomycin-Induced Lung Injury
K. Hasegawa; A. Sato; S. Sato; K. Tanimura; K. Uemasu; Y. Hamakawa; S. Muro
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2017
A New Strategy Of Facs-Based Alveolar Type Ii Cell Isolation Using Mhc Antigen In Mice
K. Hasegawa; A. Sato; K. Tanimura; Y. Fuseya; K. Uemasu; S. Sato; M. Mishima; S. Muro
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2015
Frequent Exacerbations Of COPD Cause Loss Of Antigravity Muscles - Quantitative And Longitudinal Analysis Using Chest CT
K. Tanimura; S. Sato; A. Sato; K. Hasegawa; K. Uemasu; Y. Hamakawa; T. Oguma; T. Hirai; M. Mishima; S. Muro
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2016
Functional Assessment Of Emphysematous Lung Of COPD Patients Using Oxygen-Enhanced Mri
Y. Fuseya; S. Muro; A. Kido; S. Sato; A. Sato; M. Nishioka; K. Tanimura; K. Hasegawa; T. Hirai; T. Kubo; K. Fujimoto; K. Takakura; H. Kusahara; N. Sakashita; Y. Ohno; K. Togashi; M. Mishima
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2014
Quantitative Assessment Of Chronic Bronchitis Symptoms And Impact Of Extrapulmonary Causes In COPD
K. Hasegawa; S. Muro; K. Tanimura; Y. Fuseya; M. Nishioka; A. Sato; S. Sato; T. Hirai; M. Mishima
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2014
Efficient Early Detection Of Chronic Obstructive Pulmonary Disease Using Electrocardiogram
S. Marumo; T. Takahashi; A. Sato; Y. Hoshino; S. Muro; T. Hirai; M. Mishima; A. Sato
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2011
Pathophysiology of Cigarette Smoke Induced Emphysema after Smoking Cessation in a Murine Model
S. Marumo; Y. Hoshino; N. Tanabe; A. Sato; I. Ito; E. Ogawa; S. Muro; T. Hirai; M. Mishima
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2009
Concordant distributions of respiratory volume change in emphysema and non-emphysema regions affects pulmonary function in COPD
Reduced GM-CSF autoantibody in improved lung of autoimmune pulmonary alveolar proteinosis
K. Ohashi; A. Sato; T. Takada; T. Arai; Y. Kasahara; M. Hojo; T. Nei; H. Nakayama; N. Motoi; S. Urano; R. Eda; M. Yokoba; Y. Tsuchihashi; Y. Nasuhara; H. Ishii; M. Ebina; E. Yamaguchi; Y. Inoue; K. Nakata; R. Tazawa
EUROPEAN RESPIRATORY JOURNAL, Mar. 2012
Effect Of Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) Inhalation On Bronchoalveolar Lavage Fluid And Serum In Pulmonary Alveolar ProteINOSis
R. Tazawa; K. Ohashi; A. Sato; T. Arai; Y. Kasahara; M. Hojo; M. Yokoba; Y. Tsuchihashi; H. Ishii; Y. Nasuhara; M. Ebina; T. Takada; E. Yamaguchi; Y. Inoue; K. Nakata
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2011
健診における肺年齢伝達による禁煙促進効果
MARUMO SATOSHI; MURO SHIGEO; HARUNA AKANE; SATO ATSUYASU; OGAWA EMIKO; HOSHINO YUUMA; HIRAI TOYOHIRO; MISHIMA MICHIAKI; SATO ATSUHIKO
日本呼吸器学会雑誌, 20 Mar. 2010
Characterization Of Bronchoalveolar Lavage Fluid During Granulocyte-macrophage Colony-stimulating Factor Inhalation In Patients With Autoimmune Pulmonary Alveolar Proteinosis
R. Tazawa; K. Ohashi; A. Sato; Y. Inoue; M. Akira; M. Terada; H. Nakayama; T. Takada; K. Nakata
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2010
A Cell-Free Assay System To Estimate GM-CSF Neutralizing Capacity in Autoimmuno Pulmonary Alveolar Proteinosis.
S. Urano; M. Tomita; N. Motoi; A. Sato; B. Trapnell; K. Nakata
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2009
Elucidation of Inflammatory Mechanisms by Nrf2 Regulation in a Smoking Exposure Model and Development of Novel Therapy for Laryngeal Inflammatory Disease