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Kawaguchi, Yoshiya

Center for iPS Cell Research and Application (CiRA) Professor

Kawaguchi, Yoshiya
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    Last Updated :2022/11/23

    Basic Information

    Affiliated programs (koza)

    • Graduate School of Medicine, 医学専攻 臓器形成誘導, 教授
    • Graduate School of Medicine, 医科学専攻 臓器形成誘導, 教授

    Faculty

    • 医学部

    Concurrent Affiliation

    • Center for iPS Cell Research and Application (CiRA), iPS細胞研究所 未来生命科学開拓部門, 教授

    Academic Degree

    • 医学博士(京都大学)

    ID,URL

    researchmap URL

    list
      Last Updated :2022/11/23

      Research

      Research Topics, Overview of the research

      • Research Topics

        Understanding the molecular mechanism in organogenesis, regeneration and cancer of endodermal organ
      • Overview of the research

        We try to deepen our understanding in the regulatory mechanism of cell behavior in the three dimentional structure of endodermal organ using transgenic mouse models and in vitro experiments. Especially, we focus on the similarity and difference in the cell behavior among organogenesis, regeneration and cancer.

      Papers

      • Autophagy Inhibition on In Vitro and In Vivo PanNET Models
        Nakano Kenzo; Masui Toshihiko; Yogo Akitada; Uchida Yuichiro; Nagai Kazuyuki; Anazawa Takayuki; Takaori Kyoichi; Kawaguchi Yoshiya; Uemoto Shinji
        PANCREAS, Mar. 2019, Peer-reviewed
      • Exocrine tissue-driven TFF2 prevents apoptotic cell death of endocrine lineage during pancreas organogenesis.
        Koji Hirata; Sota Kodama; Yasuhiro Nakano; Yasuko Minaki-Nakagawa; Yoshiki Aoyama; Morito Sakikubo; Toshihiko Goto; Masahiro Yoshida; Toshihiko Masui; Takuya Yamamoto; Shinji Uemoto; Yoshiya Kawaguchi
        Scientific reports, 07 Feb. 2019, Peer-reviewed
      • In vivo reprogramming drives Kras-induced cancer development
        Hirofumi Shibata; Shingo Komura; Yosuke Yamada; Nao Sankoda; Akito Tanaka; Tomoyo Ukai; Mio Kabata; Satoko Sakurai; Bunya Kuze; Knut Woltjen; Hironori Haga; Yatsuji Ito; Yoshiya Kawaguchi; Takuya Yamamoto; Yasuhiro Yamada
        Nature Communications, 01 Dec. 2018, Peer-reviewed
      • Ptf1a inactivation in adult pancreatic acinar cells causes apoptosis through activation of the endoplasmic reticulum stress pathway.
        Morito Sakikubo; Kenichiro Furuyama; Masashi Horiguchi; Shinichi Hosokawa; Yoshiki Aoyama; Kunihiko Tsuboi; Toshihiko Goto; Koji Hirata; Toshihiko Masui; Yuval Dor; Tomoyuki Fujiyama; Mikio Hoshino; Shinji Uemoto; Yoshiya Kawaguchi
        Scientific reports, 25 Oct. 2018, Peer-reviewed
      • Forebrain Ptf1a Is Required for Sexual Differentiation of the Brain
        Tomoyuki Fujiyama; Satoshi Miyashita; Yousuke Tsuneoka; Kazumasa Kanemaru; Miyo Kakizaki; Satomi Kanno; Yukiko Ishikawa; Mariko Yamashita; Tomoo Owa; Mai Nagaoka; Yoshiya Kawaguchi; Yuchio Yanagawa; Mark A. Magnuson; Masafumi Muratani; Akira Shibuya; Yo-ichi Nabeshima; Masashi Yanagisawa; Hiromasa Funato; Mikio Hoshino
        Cell Reports, 03 Jul. 2018, Peer-reviewed
      • Comparison of Recurrence Between Pancreatic and Duodenal Neuroendocrine Neoplasms After Curative Resection: A Single-Institution Analysis
        Toshihiko Masui; Asahi Sato; Kenzo Nakano; Yuichiro Uchida; Akitada Yogo; Takayuki Anazawa; Kazuyuki Nagai; Yoshiya Kawaguchi; Kyoichi Takaori; Shinji Uemoto
        Annals of Surgical Oncology, 01 Feb. 2018, Peer-reviewed
      • A Prospective Study of Intensity-modified Radiation Therapy in Comparison with Conventional 3D-RT for BR Pancreatic Cancer Patients with Arterial Involvement
        Toshihiko Masui; Kyoichi Takaori; Takayuki Anazawa; Asahi Sato; Kenzo Nakano; Yuichiro Uchida; Akitada Yogo; Yoko Goto; Shigemi Matsumoto; Yuzo Kodama; Masashi Kanai; Hiroyoshi Isoda; Masaki Mizumoto; Yoshiya Kawaguchi; Keiko Shibuya; Satoshi Itasaka; Shinji Uemoto
        ANTICANCER RESEARCH, Dec. 2017, Peer-reviewed
      • A case of successful conversion from everolimus to surgical resection of a giant pancreatic neuroendocrine tumor
        Sato Asahi; Masui Toshihiko; Sankoda Nao; Nakano Kenzo; Uchida Yuichiro; Anazawa Takayuki; Takaori Kyoichi; Kawaguchi Yoshiya; Uemoto Shinji
        SURGICAL CASE REPORTS, 20 Jul. 2017, Peer-reviewed
      • Abdominal contamination with Candida albicans after pancreaticoduodenectomy is related to hemorrhage associated with pancreatic fistulas
        Asahi Sato; Toshihiko Masui; Kenzo Nakano; Nao Sankoda; Takayuki Anazawa; Kyoichi Takaori; Yoshiya Kawaguchi; Shinji Uemoto
        PANCREATOLOGY, May 2017, Peer-reviewed
      • Liver-specific Prox1 inactivation causes hepatic injury and glucose intolerance in mice
        Toshihiko Goto; Ashraf Elbahrawy; Kenichiro Furuyama; Masashi Horiguchi; Shinichi Hosokawa; Yoshiki Aoyama; Kunihiko Tsuboi; Morito Sakikubo; Koji Hirata; Toshihiko Masui; Hajime Kubo; Yoshiharu Sakai; Shinji Uemoto; Yoshiya Kawaguchi
        FEBS LETTERS, Feb. 2017, Peer-reviewed
      • Concurrent gemcitabine+S-1 neoadjuvant chemotherapy contributes to the improved survival of patients with small borderline-resectable pancreatic cancer tumors
        Toshihiko Masui; Ryuichiro Doi; Yoshiya Kawaguchi; Asahi Sato; Kenzo Nakano; Tatsuo Ito; Takayuki Anazawa; Kyoichi Takaori; Shinji Uemoto
        SURGERY TODAY, Nov. 2016, Peer-reviewed
      • Nardilysin Is Required for Maintaining Pancreatic beta-Cell Function
        Kiyoto Nishi; Yuichi Sato; Mikiko Ohno; Yoshinori Hiraoka; Sayaka Saijo; Jiro Sakamoto; Po-Min Chen; Yusuke Morita; Shintaro Matsuda; Kanako Iwasaki; Kazu Sugizaki; Norio Harada; Yoshiko Mukumoto; Hiroshi Kiyonari; Kenichiro Furuyama; Yoshiya Kawaguchi; Shinji Uemoto; Toru Kita; Nobuya Inagaki; Takeshi Kimura; Eiichiro Nishi
        DIABETES, Oct. 2016, Peer-reviewed
      • Concomitant Case of Intraductal Papillary Mucinous Neoplasm of the Pancreas and Functioning Pancreatic Neuroendocrine Tumor (Vasoactive Intestinal Polypeptide-Producing Tumor) First Report
        Shoko Ishizu; Takeshi Setoyama; Taro Ueo; Yoshihide Ueda; Yuzo Kodama; Hiroshi Ida; Yoshiya Kawaguchi; Akihiko Yoshizawa; Tsutomu Chiba; Shin'ichi Miyamoto
        PANCREAS, Jul. 2016, Peer-reviewed
      • SOX9 is a novel cancer stem cell marker surrogated by osteopontin in human hepatocellular carcinoma
        Takayuki Kawai; Kentaro Yasuchika; Takamichi Ishii; Yuya Miyauchi; Hidenobu Kojima; Ryoya Yamaoka; Hokahiro Katayama; Elena Yukie Yoshitoshi; Satoshi Ogiso; Sadahiko Kita; Katsutaro Yasuda; Ken Fukumitsu; Junji Komori; Etsuro Hatano; Yoshiya Kawaguchi; Shinji Uemoto
        SCIENTIFIC REPORTS, Jul. 2016, Peer-reviewed
      • Origins of oligodendrocytes in the cerebellum, whose development is controlled by the transcription factor, Sox9
        Ryoya Hashimoto; Kei Hori; Tomoo Owa; Satoshi Miyashita; Kenichi Dewa; Norihisa Masuyama; Kazuhisa Sakai; Yoneko Hayase; Yusuke Seto; Yukiko U. Inoue; Takayoshi Inoue; Noritaka Ichinohe; Yoshiya Kawaguchi; Haruhiko Akiyama; Schuichi Koizumi; Mikio Hoshino
        MECHANISMS OF DEVELOPMENT, May 2016, Peer-reviewed
      • Proteasome activity is required for the initiation of precancerous pancreatic lesions
        Takaki Furuyama; Shinji Tanaka; Shu Shimada; Yoshimitsu Akiyama; Satoshi Matsumura; Yusuke Mitsunori; Arihiro Aihara; Daisuke Ban; Takanori Ochiai; Atsushi Kudo; Hiroshi Fukamachi; Shigeki Arii; Yoshiya Kawaguchi; Minoru Tanabe
        SCIENTIFIC REPORTS, May 2016, Peer-reviewed
      • Diabetes Caused by Elastase-Cre-Mediated Pdx1 Inactivation in Mice
        Sota Kodama; Yasuhiro Nakano; Koji Hirata; Kenichiro Furuyama; Masashi Horiguchi; Takeshi Kuhara; Toshihiko Masui; Michiya Kawaguchi; Maureen Gannon; Christopher V. E. Wright; Shinji Uemoto; Yoshiya Kawaguchi
        SCIENTIFIC REPORTS, Feb. 2016, Peer-reviewed
      • Spatiotemporal regulation of neural progenitor identities by transcription factors
        Mikio Hoshino; Yusuke Seto; Tomoya Nakatani; Yoshiya Kawaguchi; Kazuhiro Ikenaka; Hirohide Takebayashi; Yuichi Ono; Mayumi Yamada
        INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, Dec. 2015, Peer-reviewed
      • A case report of a type 1 diabetes patient maintaining C-peptide secretion for ten years after islet transplantation using donation after cardiocirculatory death (DCD) donors
        Yasuhiro Iwanaga; Shinichi Matsumoto; Teru Okitsu; Hideo Nagata; Hirofumi Noguchi; Yukihide Yonekawa; Michiya Kawaguchi; Takayuki Anazawa; Yoshiya Kawaguchi; Hideaki Okajima; Shinji Uemoto
        XENOTRANSPLANTATION, Nov. 2015, Peer-reviewed
      • A CASE REPORT OF A TYPE 1 DIABETES PATIENT MAINTAINING C-PEPTIDE SECRETION FOR TEN YEARS AFTER ISLET TRANSPLANTATION USING DONATION AFTER CARDIOCIRCULATORY DEATH (DCD) DONORS.
        Yasuhiro Iwanaga; Shinichi Matsumoto; Teru Okitsu; Hideo Nagata; Hirofumi Noguchi; Yukihide Yonekawa; Michiya Kawaguchi; Takayuki Anazawa; Yoshiya Kawaguchi; Hideaki Okajima; Shinji Uemoto
        TRANSPLANTATION, Nov. 2015, Peer-reviewed
      • Disappearance of centroacinar cells in the Notch ligand-deficient pancreas
        Yasuhiro Nakano; Naoko Negishi; Seiho Gocho; Tetsuya Mine; Yuri Sakurai; Masaki Yazawa; Koichiro Abe; Hideo Yagita; Sonoko Habu; Ryoichiro Kageyama; Yoshiya Kawaguchi; Katsuto Hozumi
        GENES TO CELLS, Jun. 2015, Peer-reviewed
      • Cell aggregation optimizes the differentiation of human ESCs and iPSCs into pancreatic bud-like progenitor cells
        Taro Toyoda; Shin-Ichi Mae; Hiromi Tanaka; Yasushi Kondo; Michinori Funato; Yoshiya Hosokawa; Tomomi Sudo; Yoshiya Kawaguchi; Kenji Osafune
        STEM CELL RESEARCH, Mar. 2015, Peer-reviewed
      • Impact of Sox9 Dosage and Hes1-mediated Notch Signaling in Controlling the Plasticity of Adult Pancreatic Duct Cells in Mice
        Shinichi Hosokawa; Kenichiro Furuyama; Masashi Horiguchi; Yoshiki Aoyama; Kunihiko Tsuboi; Morito Sakikubo; Toshihiko Goto; Koji Hirata; Wataru Tanabe; Yasuhiro Nakano; Haruhiko Akiyama; Ryoichiro Kageyama; Shinji Uemoto; Yoshiya Kawaguchi
        SCIENTIFIC REPORTS, Feb. 2015, Peer-reviewed
      • Activation of GLP-1 and Gastrin Signaling Induces beta-Cell Neogenesis
        Shugo Sasaki; Takeshi Miyatsuka; Mitsuyoshi Takahara; Fumiyo Kubo; Kazuyuki Miyashita; Yuichi Yamamoto; Tetsuyuki Yasuda; Yoshiya Kawaguchi; Haruhiko Akiyama; Hideaki Kaneto; Taka-Aki Matsuoka; Hirotaka Watada; Iichiro Shimomura
        DIABETES, Jun. 2014, Peer-reviewed
      • Comparative Outcomes Between Initially Unresectable and Recurrent Cases of Advanced Pancreatic Cancer Following Palliative Chemotherapy
        Peng Xue; Masashi Kanai; Yukiko Mori; Takafumi Nishimura; Norimitsu Uza; Yuzo Kodama; Yoshiya Kawaguchi; Kyoichi Takaori; Shigemi Matsumoto; Shinji Uemoto; Tsutomu Chiba
        PANCREAS, Apr. 2014, Peer-reviewed
      • Specification of Spatial Identities of Cerebellar Neuron Progenitors by Ptf1a and Atoh1 for Proper Production of GABAergic and Glutamatergic Neurons
        Mayumi Yamada; Yusuke Seto; Shinichiro Taya; Tomoo Owa; Yukiko U. Inoue; Takayoshi Inoue; Yoshiya Kawaguchi; Yo-ichi Nabeshima; Mikio Hoshino
        JOURNAL OF NEUROSCIENCE, Apr. 2014, Peer-reviewed
      • Neutrophil-to-lymphocyte ratio for predicting palliative chemotherapy outcomes in advanced pancreatic cancer patients
        Peng Xue; Masashi Kanai; Yukiko Mori; Takafumi Nishimura; Norimitsu Uza; Yuzo Kodama; Yoshiya Kawaguchi; Kyoichi Takaori; Shigemi Matsumoto; Shinji Uemoto; Tsutomu Chiba
        CANCER MEDICINE, Apr. 2014, Peer-reviewed
      • Radiotherapy for patients with isolated local recurrence of primary resected pancreatic cancer - Prolonged disease-free interval associated with favorable prognosis
        A. Nakamura; S. Itasaka; K. Takaori; Y. Kawaguchi; K. Shibuya; M. Yoshimura; Y. Matsuo; T. Mizowaki; S. Uemoto; M. Hiraoka
        Strahlentherapie und Onkologie, Apr. 2014, Peer-reviewed
      • Temporal identity transition from Purkinje cell progenitors to GABAergic interneuron progenitors in the cerebellum
        Yusuke Seto; Tomoya Nakatani; Norihisa Masuyama; Shinichiro Taya; Minoru Kumai; Yasuko Minaki; Akiko Hamaguchi; Yukiko U. Inoue; Takayoshi Inoue; Satoshi Miyashita; Tomoyuki Fujiyama; Mayumi Yamada; Heather Chapman; Kenneth Campbell; Mark A. Magnuson; Christopher V. Wright; Yoshiya Kawaguchi; Kazuhiro Ikenaka; Hirohide Takebayashi; Shin'ichi Ishiwata; Yuichi Ono; Mikio Hoshino
        NATURE COMMUNICATIONS, Feb. 2014, Peer-reviewed
      • Expression of SOX9 in Intraductal Papillary Mucinous Neoplasms of the Pancreas
        Fanbin Meng; Kyoichi Takaori; Tatsuo Ito; Toshihiko Masui; Michiya Kawaguchi; Yoshiya Kawaguchi; Shinji Uemoto
        PANCREAS, Jan. 2014, Peer-reviewed
      • CAPS1 Deficiency Perturbs Dense-Core Vesicle Trafficking and Golgi Structure and Reduces Presynaptic Release Probability in the Mouse Brain
        Tetsushi Sadakata; Wataru Kakegawa; Yo Shinoda; Mayu Hosono; Ritsuko Katoh-Semba; Yukiko Sekine; Yumi Sato; Mika Tanaka; Takuji Iwasato; Shigeyoshi Itohara; Kenichiro Furuyama; Yoshiya Kawaguchi; Yasuki Ishizaki; Michisuke Yuzaki; Teiichi Furuichi
        JOURNAL OF NEUROSCIENCE, Oct. 2013, Peer-reviewed
      • Sox9 and programming of liver and pancreatic progenitors
        Yoshiya Kawaguchi
        JOURNAL OF CLINICAL INVESTIGATION, May 2013, Peer-reviewed
      • Dclk1 distinguishes between tumor and normal stem cells in the intestine
        Y. Nakanishi; H. Seno; A. Fukuoka; T. Ueo; Y. Yamaga; T. Maruno; N. Nakanishi; K. Kanda; H. Komekado; M. Kawada; A. Isomura; K. Kawada; Y. Sakai; M. Yanagita; R. Kageyama; Y. Kawaguchi; M.M. Taketo; S. Yonehara; T. Chiba
        Nature Genetics, 2013, Peer-reviewed
      • GPR119 expression in normal human tissues and islet cell tumors: Evidence for its islet-gastrointestinal distribution, expression in pancreatic beta and alpha cells, and involvement in islet function
        Shinji Odori; Kiminori Hosoda; Tsutomu Tomita; Junji Fujikura; Toru Kusakabe; Yoshiya Kawaguchi; Ryuichiro Doi; Kyoichi Takaori; Ken Ebihara; Yoshiharu Sakai; Shinji Uemoto; Kazuwa Nakao
        Metabolism: Clinical and Experimental, Jan. 2013, Peer-reviewed
      • Dclk1 distinguishes between tumor and normal stem cells in the intestine
        Yuki Nakanishi; Hiroshi Seno; Ayumi Fukuoka; Taro Ueo; Yuichi Yamaga; Takahisa Maruno; Naoko Nakanishi; Keitaro Kanda; Hideyuki Komekado; Mayumi Kawada; Akihiro Isomura; Kenji Kawada; Yoshiharu Sakai; Motoko Yanagita; Ryoichiro Kageyama; Yoshiya Kawaguchi; Makoto M. Taketo; Shin Yonehara; Tsutomu Chiba
        NATURE GENETICS, Jan. 2013, Peer-reviewed
      • Delayed gastric emptying improved by straight stomach reconstruction with twisted anastomosis to the jejunum after pylorus-preserving pancreaticoduodenectomy (PPPD) in 118 consecutive patients at a single institution
        Toshihiko Masui; Ryuchiro Doi; Yoshiya Kawaguchi; Shinji Uemoto
        SURGERY TODAY, May 2012, Peer-reviewed
      • Definitive radiotherapy for patients with isolated local recurrence of primary resected pancreatic cancer: A retrospective analysis.
        Akira Nakamura; Keiko Shibuya; Kyoichi Takaori; Yoshiya Kawaguchi; Michio Yoshimura; Yukinori Matsuo; Satoshi Itasaka; Masahiro Hiraoka
        JOURNAL OF CLINICAL ONCOLOGY, Feb. 2012, Peer-reviewed
      • Successful Neoadjuvant Treatment with Radiochemotherapy and Systemic Chemotherapy for the Locally Advanced Pancreatic Head Cancer: Report of a Case
        Toshihiko Masui; Ryuichiro Doi; Kohei Ogawa; Kazuhiro Kami; Takafumi Machimoto; Satoru Seo; Yoshiya Kawaguchi; Hiroto Egawa; Yasuhiro Matsugu; Shinji Uemoto
        HEPATO-GASTROENTEROLOGY, Sep. 2011, Peer-reviewed
      • In vitro generation of insulin-secreting cells from human pancreatic exocrine cells
        Kohtaro Minami; Ryuichiro Doi; Yoshiya Kawaguchi; Daiki Nukaya; Yoshiaki Hagiwara; Hirofumi Noguchi; Shinichi Matsumoto; Susumu Seino
        JOURNAL OF DIABETES INVESTIGATION, Aug. 2011, Peer-reviewed
      • A phase I/II study of gemcitabine-based chemotherapy plus curcumin for patients with gemcitabine-resistant pancreatic cancer
        Masashi Kanai; Kenichi Yoshimura; Masanori Asada; Atsushi Imaizumi; Chihiro Suzuki; Shigemi Matsumoto; Takafumi Nishimura; Yukiko Mori; Toshihiko Masui; Yoshiya Kawaguchi; Kazuhiro Yanagihara; Shujiro Yazumi; Tsutomu Chiba; Sushovan Guha; Bharat B. Aggarwal
        CANCER CHEMOTHERAPY AND PHARMACOLOGY, Jul. 2011, Peer-reviewed
      • A Case of Progressive Digital Ischemia after Early Withdrawal of Gemcitabine and S-1 in a Patient with Systemic Sclerosis
        C. Zaima; M. Kanai; S. Ishikawa; Y. Kawaguchi; T. Masui; Y. Mori; T. Nishimura; S. Matsumoto; K. Yanagihara; T. Chiba; T. Mimori
        JAPANESE JOURNAL OF CLINICAL ONCOLOGY, Jun. 2011, Peer-reviewed
      • Adenoendocrine cell carcinoma of the extrahepatic bile duct: A case report and review of the literature
        Toshihiko Masui; Ryuichiro Doi; Yoshiya Kawaguchi; Yasuhiro Iwanaga; Tatsuo Ito; Masayuki Koizumi; Shinji Uemoto
        Clinical Journal of Gastroenterology, Jun. 2011, Peer-reviewed
      • RBP-J promotes the maturation of neuronal progenitors
        Okiru Komine; Mai Nagaoka; Yuichi Hiraoka; Mikio Hoshino; Yoshiya Kawaguchi; Warren S. Pear; Kohichi Tanaka
        DEVELOPMENTAL BIOLOGY, Jun. 2011, Peer-reviewed
      • Thrombotic microangiopathy-like disorder after living-donor liver transplantation: A single-center experience in Japan
        Tomohide Hori; Toshimi Kaido; Fumitaka Oike; Yasuhiro Ogura; Kohei Ogawa; Yukihide Yonekawa; Koichiro Hata; Yoshiya Kawaguchi; Mikiko Ueda; Akira Mori; Hajime Segawa; Kimiko Yurugi; Yasutsugu Takada; Hiroto Egawa; Atsushi Yoshizawa; Takuma Kato; Kanako Saito; Linan Wang; Mie Torii; Feng Chen; Ann-Marie T. Baine; Lindsay B. Gardner; Shinji Uemoto
        WORLD JOURNAL OF GASTROENTEROLOGY, Apr. 2011, Peer-reviewed
      • The distribution of atypical epithelium in main-duct type intraductal papillary mucinous neoplasms of the pancreas
        Tatsuo Ito; Ryuichiro Doi; Akihiko Yoshizawa; Morito Sakikubo; Kazuyuki Nagai; Atsushi Kida; Masayuki Koizumi; Toshihiko Masui; Yoshiya Kawaguchi; Toshiaki Manabe; Shinji Uemoto
        JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES, Mar. 2011, Peer-reviewed
      • Genetic studies on the development and function of the hypothalamus using Ptf1a-Cre & -flox knock-in mice
        Tomoyuki Fujiyama; Mai Nagaoka; Yuchio Yanagawa; Mark Magnuson; Kunihiko Obata; Yoshiya Kawaguchi; Yo-ichi Nabeshima; Mikio Hoshino
        NEUROSCIENCE RESEARCH, 2011, Peer-reviewed
      • Noninvasive Intraductal Papillary Mucinous Neoplasm with Para-Aortic Lymph Node Metastasis: Report of a Case
        Kazuyuki Nagai; Ryuichiro Doi; Masayuki Koizumi; Toshihiko Masui; Yoshiya Kawaguchi; Akihiko Yoshizawa; Shinji Uemoto
        SURGERY TODAY, Jan. 2011, Peer-reviewed
      • Genetic lineage tracing, a powerful tool to investigate the embryonic organogenesis and adult organ maintenance of the pancreas
        Yoshiya Kawaguchi; Kyoichi Takaori; Shinji Uemoto
        JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES, Jan. 2011, Peer-reviewed
      • Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine
        Kenichiro Furuyama; Yoshiya Kawaguchi; Haruhiko Akiyama; Masashi Horiguchi; Sota Kodama; Takeshi Kuhara; Shinichi Hosokawa; Ashraf Elbahrawy; Tsunemitsu Soeda; Masayuki Koizumi; Toshihiko Masui; Michiya Kawaguchi; Kyoichi Takaori; Ryuichiro Doi; Eiichiro Nishi; Ryosuke Kakinoki; Jian Min Deng; Richard R. Behringer; Takashi Nakamura; Shinji Uemoto
        NATURE GENETICS, Jan. 2011, Peer-reviewed
      • Laparoscopic common hepatic artery ligation and staging followed by distal pancreatectomy with en bloc resection of celiac artery for advanced pancreatic cancer.
        V. Raut; K. Takaori; Y. Kawaguchi; M. Mizumoto; M. Kawaguchi; M. Koizumi; S. Kodama; A. Kida; S. Uemoto
        Asian journal of endoscopic surgery, 2011, Peer-reviewed
      • Usefullness of Selective Arterial Secretagogue Injection Test by Calcium for Diagnosis of Pancreatic Gastrinoma: A Case Report
        Naoko Kamo; Ryuichiro Doi; Hisashi Imai; Toshihiko Masui; Yasuhiro Iwanaga; Yoshiya Kawaguchi; Yasutsugu Takada; Noritsugu Ohashi; Shinji Uemoto
        PANCREAS, Jul. 2010, Peer-reviewed
      • Adenosquamous Carcinoma of the Pancreas With the Special Feature of Strong Uptake on FDG-PET
        Tatsuo Itoh; Ryuichiro Doi; Yuji Nakamoto; Hiroshi Takahashi; Toshihiko Masui; Hisashi Imai; Naoko Kamo; Yasuhiro Iwanaga; Yoshiya Kawaguchi; Yasutsugu Takada; Shinji Uemoto
        PANCREAS, Jul. 2010, Peer-reviewed
      • Coupled regulation of interleukin-12 receptor beta-1 of CD8+central memory and CCR7-negative memory T cells in an early alloimmunity in liver transplant recipients
        H. Egawa; K. Ozawa; Y. Takada; S. Teramukai; A. Mori; K. Ogawa; T. Kaido; Y. Fujimoto; Y. Kawaguchi; E. Hatano; H. Sato; M. Ono; K. Takai; K. Tanaka; S. Uemoto
        CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Jun. 2010, Peer-reviewed
      • Preoperative assessment of para-aortic lymph node metastasis in patients with pancreatic cancer
        Hisashi Imai; Ryuichiro Doi; Hiroyuki Kanazawa; Naoko Kamo; Masayuki Koizumi; Toshihiko Masui; Yasuhiro Iwanaga; Yoshiya Kawaguchi; Yasutsugu Takada; Hiroyoshi Isoda; Shinji Uemoto
        INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, Jun. 2010, Peer-reviewed
      • Physiological roles of the Hes1 in the pancreas
        Junji Fujikura; Masaki Naito; Kiminori Hosoda; Hiroshi Iwakura; Tsutomu Tomita; Michio Noguchi; Shinji Odori; Eisaku Mori; Chisako Kozuka; Yuji Yamamoto; Ken Ebihara; Hiroaki Masuzaki; Yoshiya Kawaguchi; Rhoichiro Kageyama; Kazuwa Nakao
        ENDOCRINE JOURNAL, Mar. 2010, Peer-reviewed
      • Function and mutual expression control of bHLH transcription factors, Ptf1a and Atoh1, in the developing cerebellum
        Mayumi Yamada; Shinichiro Taya; Tomoo Owa; Yoshiya Kawaguchi; Yo-ichi Nabeshima; Mikio Hoshino
        NEUROSCIENCE RESEARCH, 2010, Peer-reviewed
      • Ptf1a Directly Controls Expression of Immunoglobulin Superfamily Molecules Nephrin and Neph3 in the Developing Central Nervous System
        Kazuhiko Nishida; Mikio Hoshino; Yoshiya Kawaguchi; Fujio Murakami
        JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 2010, Peer-reviewed
      • Premedication with 20 mg dexamethasone effectively prevents relapse of extensive skin rash associated with gemcitabine monotherapy
        M. Kanai; S. Matsumoto; T. Nishimura; Y. Matsumura; E. Hatano; A. Mori; T. Masui; Y. Kawaguchi; E. Nakamura; S. Tada; T. Kitano; H. Ishiguro; K. Yanagihara; T. Chiba
        ANNALS OF ONCOLOGY, Jan. 2010, Peer-reviewed
      • Stringent Specificity in the Construction of a GABAergic Presynaptic Inhibitory Circuit
        J. Nicholas Betley; Christopher V. E. Wright; Yoshiya Kawaguchi; Ferenc Erdelyi; Gabor Szabo; Thomas M. Jessell; Julia A. Kaltschmidt
        CELL, Oct. 2009, Peer-reviewed
      • Kyoto islet isolation method allows efficient islet retrieval from young donor pancreas for clinical use
        Yasuhiro Iwanaga; Shinichi Matsumoto; Hirohumi Noguchi; Teru Okitsu; Yoshiya Kawaguchi; Shinji Uemoto
        XENOTRANSPLANTATION, Sep. 2009, Peer-reviewed
      • Inhibitory and excitatory subtypes of cochlear nucleus neurons are defined by distinct bHLH transcription factors, Ptf1a and Atoh1
        Tomoyuki Fujiyama; Mayumi Yamada; Mami Terao; Toshio Terashima; Hiroyuki Hioki; Yukiko U. Inoue; Takayoshi Inoue; Norihisa Masuyama; Kunihiko Obata; Yuchio Yanagawa; Yoshiya Kawaguchi; Yo-ichi Nabeshima; Mikio Hoshino
        DEVELOPMENT, Jun. 2009, Peer-reviewed
      • Single-institution validation of the international consensus guidelines for treatment of branch duct intraductal papillary mucinous neoplasms of the pancreas
        Kazuyuki Nagai; Ryuichiro Doi; Tatsuo Ito; Atsushi Kida; Masayuki Koizumi; Toshihiko Masui; Yoshiya Kawaguchi; Kohei Ogawa; Shinji Uemoto
        JOURNAL OF HEPATO-BILIARY-PANCREATIC SURGERY, May 2009, Peer-reviewed
      • Prognostic value of metastin expression in human pancreatic cancer
        Kazuyuki Nagai; Ryuichiro Doi; Fumihiko Katagiri; Tatsuo Ito; Atsushi Kida; Masayuki Koizumi; Toshihiko Masui; Yoshiya Kawaguchi; Kenji Tomita; Shinya Oishi; Nobutaka Fujii; Shinji Uemoto
        JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, Jan. 2009, Peer-reviewed
      • Reduction of Ptf1a gene dosage causes pancreatic hypoplasia and diabetes in mice
        Akihisa Fukuda; Yoshiya Kawaguchi; Kenichiro Furuyama; Sota Kodama; Masashi Horiguchi; Takeshi Kuhara; Michiya Kawaguchi; Mami Terao; Ryuichiro Doi; Christopher V. E. Wright; Mikio Hoshino; Tsutomu Chiba; Shinji Uemoto
        DIABETES, Sep. 2008, Peer-reviewed
      • Combined chemotherapy with S-1 and gemcitabine induced duodenal penetration of pancreatic head cancer: Report of a case
        Masaharu Tada; Ryuichiro Doi; Kazuhiro Kami; Kohei Ogawa; Yoshiya Kawaguchi; Hiroto Egawa; Shinji Uemoto
        PANCREAS, Jul. 2008, Peer-reviewed
      • GABA and synaptic inhibition of mouse cerebellum lacking glutamate decarboxylase 67
        Kunihiko Obata; Moritoshi Hirono; Nobuko Kume; Yoshiya Kawaguchi; Shigeyoshi Itohara; Yuchio Yanagawa
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jun. 2008, Peer-reviewed
      • Use of acetaminophen during mixed meal testing to assess the effect of exenatide on gastric emptying in islet transplant recipients
        Teru Okitsu; Yasuhiro Iwanaga; Yoshiya Kawaguchi; Michiya Kawaguchi; Kentaro Toyoda; Hirohumi Noguchi; Hideo Nagata; Yukihide Yonekawa; Nobuya Inagaki; Shinichi Matsumoto; Shinji Uemoto
        AMERICAN JOURNAL OF TRANSPLANTATION, May 2008, Peer-reviewed
      • Clinical outcome of gemcitabine/S-1 combination therapy for advanced pancreatic cancer
        Junichi Yamauchi; Masashi Kanai; Shigemi Matsumoto; Takafumi Nishimura; Shujiro Yazumi; Kazuhiro Kami; Yoshiya Kawaguchi; Hiroyasu Yasuda; Toshiyuki Kitano; Akiko Misawa; Hiroshi Ishiguro; Kiyotsugu Yoshikawa; Kazuhiro Yanagihara; Masanori Fukushima; Ryuichiro Doi; Tsutomu Chiba
        PANCREAS, Apr. 2008, Peer-reviewed
      • Intraductal papillary mucinous neoplasms of the pancreas: Clinicopathologic characteristics and long-term follow-up after resection
        Kazuyuki Nagai; Ryuichiro Doi; Atsushi Kida; Kazuhiro Kami; Yoshiya Kawaguchi; Tatsuo Ito; Takaki Sakurai; Shinji Uemoto
        WORLD JOURNAL OF SURGERY, Feb. 2008, Peer-reviewed
      • Genetic studies on the development of cochlear nucleus neurons using Ptf1a-cre knock-in mice
        Tomoyuki Fujiyama; Mayumi Yamada; Mami Terao; Toshio Terashima; Yuchio Yanagawa; Kunihiko Obata; Yoshiya Kawaguchi; Yo-Ichi Nabeshima; Mikio Hoshino
        NEUROSCIENCE RESEARCH, 2008, Peer-reviewed
      • A new technique for intraoperative continuous biliary drainage during pancreatoduodenectomy
        Ryuichiro Doi; Kazuhiro Kami; Atsushi Kida; Kazuyuki Nagai; Kohei Ogawa; Yoshiya Kawaguchi; Hiroto Egawa; Shinji Uemoto
        DIGESTIVE SURGERY, 2008, Peer-reviewed
      • Rbp-j regulates expansion of pancreatic epithelial cells and their differentiation into exocrine cells during mouse development
        Junji Fujikura; Kiminori Hosoda; Yoshiya Kawaguchi; Michio Noguchi; Hiroshi Iwakura; Shinji Odori; Eisaku Mori; Tsutomu Tomita; Masakazu Hirata; Ken Ebihara; Hiroaki Masuzaki; Akihisa Fukuda; Kenichiro Furuyama; Kenji Tanigaki; Daisuke Yabe; Kazuwa Nakao
        DEVELOPMENTAL DYNAMICS, Oct. 2007, Peer-reviewed
      • Origin of climbing fiber neurons and their developmental dependence on Ptf1a
        Mayumi Yamada; Mami Terao; Toshio Terashima; Tomoyuki Fujiyama; Yoshiya Kawaguchi; Yo-ichi Nabeshima; Mikio Hoshino
        JOURNAL OF NEUROSCIENCE, Oct. 2007, Peer-reviewed
      • Effect of the XIAP inhibitor embelin on TRAIL-induced apoptosis of pancreatic cancer cells
        Tomohiko Mori; Ryuichiro Doi; Atsushi Kida; Kazuyuki Nagai; Kazuhiro Kami; Daisuke Ito; Eiji Toyoda; Yoshiya Kawaguchi; Shinji Uemoto
        JOURNAL OF SURGICAL RESEARCH, Oct. 2007, Peer-reviewed
      • Origin of climbing fiber neurons and their developmental dependence on Ptf1a
        Mayumi Yamada; Mami Terao; Toshio Terashima; Tomoyuki Fujiyama; Yoshiya Kawaguchi; Yo-Ichi Nabeshima; Mikio Hoshino
        NEUROSCIENCE RESEARCH, 2007, Peer-reviewed
      • What the developmental biology in pancreatogenesis brought us: insights in human diseases and possible application to the regenerative therapy for diabetes
        Y. Kawaguchi
        Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2007, Peer-reviewed
      • A case of ruptured liver abscess caused by Clostridium perfringens after pancreatoduodenectomy
        Masaharu Tada; Ryuichiro Doi; Kohei Ogawa; Yoshiya Kawaguchi; Hiroto Egawa; Fumihiko Hirai; Shinji Uemoto
        Japanese Journal of Gastroenterological Surgery, 2007, Peer-reviewed
      • Prognostic implication of para-aortic lymph node metastasis in resectable pancreatic cancer
        Ryuichiro Doi; Kazuhiro Kami; Daisuke Ito; Koji Fujimoto; Yoshiya Kawaguchi; Michihiko Wada; Masafumi Kogire; Ryo Hosotani; Masayuki Imamura; Shinji Uemoto
        WORLD JOURNAL OF SURGERY, Jan. 2007, Peer-reviewed
      • Ptf1a determines horizontal and amacrine cell fates during mouse retinal development
        Yoshio Fujitani; Shuko Fujitani; Huijun Luo; Feng Qiu; Jared Burlison; Qiaoming Long; Yoshiya Kawaguchi; Helena Edlund; Raymond J. MacDonald; Takahisa Furukawa; Takashi Fujikado; Mark A. Magnuson; Mengqing Xiang; Christopher V. E. Wright
        DEVELOPMENT, Nov. 2006, Peer-reviewed
      • Forced expression of PDX-1 induces insulin production in intestinal epithelia
        Masayuki Koizumi; Kazuyuki Nagai; Atsushi Kida; Kazuhiro Kami; Daisuke Ito; Koji Fujimoto; Yoshiya Kawaguchi; Ryuichiro Doi
        SURGERY, Aug. 2006, Peer-reviewed
      • Ectopic pancreas formation in Hes1-knockout mice reveals plasticity of endodermal progenitors of the gut, bile duct, and pancreas
        A Fukuda; Y Kawaguchi; K Furuyama; S Kodama; M Horiguchi; T Kuhara; M Koizumi; DF Boyer; K Fujimoto; R Doi; R Kageyama; CVE Wright; T Chiba
        JOURNAL OF CLINICAL INVESTIGATION, Jun. 2006, Peer-reviewed
      • Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activation
        T Miyatsuka; H Kaneto; T Shiraiwa; TA Matsuoka; K Yamamoto; K Kato; Y Nakamura; S Akira; K Takeda; Y Kajimoto; Y Yamasaki; EP Sandgren; Y Kawaguchi; CVE Wright; Y Fujitani
        GENES & DEVELOPMENT, Jun. 2006, Peer-reviewed
      • Expression of the gene for a membrane-bound fatty acid receptor in the pancreas and islet cell tumours in humans: evidence for GPR40 expression in pancreatic beta cells and implications for insulin secretion
        T Tomita; H Masuzuaki; H Iwakura; J Fujikura; M Noguchi; T Tanaka; K Ebihara; J Kawamura; Komoto, I; Y Kawaguchi; K Fujimoto; R Doi; Y Shimada; K Hosoda; M Imamura; K Nakao
        DIABETOLOGIA, May 2006, Peer-reviewed
      • In vivo antitumor effect of the mTOR inhibitor CCI-779 and gemcitabine in xenograft models of human pancreatic cancer
        D Ito; K Fujimoto; T Mori; K Kami; M Koizumi; E Toyoda; Y Kawaguchi; R Doi
        INTERNATIONAL JOURNAL OF CANCER, May 2006, Peer-reviewed
      • Loss of the major duodenal papilla results in brown pigment biliary stone formation in pdx1 null mice
        A Fukuda; Y Kawaguchi; K Furuyama; S Kodama; T Kuhara; M Horiguchi; M Koizumi; K Fujimoto; R Doi; CVE Wright; T Chiba
        GASTROENTEROLOGY, Mar. 2006, Peer-reviewed
      • Mesenchymal epimorphin is important for pancreatic duct morphogenesis
        SS Tulachan; R Doi; Y Hirai; Y Kawaguchi; M Koizumi; M Hembree; E Tei; A Crowley; H Yew; C McFall; K Prasadan; B Preuett; M Imamura; GK Gittes
        DEVELOPMENT GROWTH & DIFFERENTIATION, Feb. 2006, Peer-reviewed
      • Clinical significance of focal adhesion kinase in resectable pancreatic cancer
        K Furuyama; R Doi; T Mori; E Toyoda; D Ito; K Kami; M Koizumi; A Kida; Y Kawaguchi; K Fujimoto
        WORLD JOURNAL OF SURGERY, Feb. 2006, Peer-reviewed
      • Surgical treatment of carcinoma of the pancreas
        R. Doi; K. Kami; D. Ito; Y. Kawaguchi; S. Uemoto; S. Yoshida
        Nippon Geka Gakkai zasshi, 2006, Peer-reviewed
      • Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation
        Y Fujitani; S Fujitani; DF Boyer; M Gannon; Y Kawaguchi; M Ray; M Shiota; RW Stein; MA Magnuson; CVE Wright
        GENES & DEVELOPMENT, Jan. 2006, Peer-reviewed
      • GPR40 gene expression in human pancreas and insulinoma
        T Tomita; H Masuzaki; M Noguchi; H Iwakura; J Fujikura; T Tanaka; K Ebihara; J Kawamura; Komoto, I; Y Kawaguchi; K Fujimoto; R Doi; Y Shimada; K Hosoda; M Imamura; K Nakao
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Dec. 2005, Peer-reviewed
      • Downregulation of survivin by siRNA diminishes radioresistance of pancreatic cancer cells
        K Kami; R Doi; M Koizumi; E Toyoda; T Mori; D Ito; Y Kawaguchi; K Fujimoto; M Wada; SI Miyatake; M Imamura
        SURGERY, Aug. 2005, Peer-reviewed
      • Pancreatic epithelial cells can be converted into insulin-producing cells by GLP-1 in conjunction with virus-mediated gene transfer of pdx-1
        M Koizumi; R Doi; K Fujimoto; D Ito; E Toyoda; T Mori; K Kami; Y Kawaguchi; GK Gittes; M Imamura
        SURGERY, Aug. 2005, Peer-reviewed
      • Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum
        M Hoshino; S Nakamura; K Mori; T Kawauchi; M Terao; YV Nishimura; A Fukuda; T Fuse; N Matsuo; M Sone; M Watanabe; H Bito; T Terashima; CVE Wright; Y Kawaguchi; K Nakao; YI Nabeshima
        NEURON, Jul. 2005, Peer-reviewed
      • Regulation of the resistance to TRAIL-induced apoptosis as a new strategy for pancreatic cancer
        T Mori; R Doi; E Toyoda; M Koizumi; D Ito; K Kami; A Kida; T Masui; Y Kawaguchi; K Fujimoto
        SURGERY, Jul. 2005, Peer-reviewed
      • Hepatic regeneration and enforced PDX-1 expression accelerate transdifferentiation in liver
        M Koizumi; R Doi; E Toyoda; SS Tulachan; K Kami; T Mori; D Ito; Y Kawaguchi; K Fujimoto; GK Gittes; M Imamura
        SURGERY, Aug. 2004, Peer-reviewed
      • Chronic exposure of transforming growth factor, beta 1 confers a more aggressive tumor phenotype through downregulation of p21 (WAF1/CIP1) in conditionally immortalized pancreatic epithelial cells
        D Ito; K Fujimoto; R Doi; M Koizumi; E Toyoda; T Mori; K Kami; Y Kawaguchi; R Whitehead; M Imamura
        SURGERY, Aug. 2004, Peer-reviewed
      • N-cadherin expression and epithelial-mesenchymal transition in pancreatic carcinoma
        S Nakajima; R Doi; E Toyoda; S Tsuji; M Wada; M Koizumi; SS Tulachan; D Ito; K Kami; T Mori; Y Kawaguchi; K Fujimoto; R Hosotani; M Imamura
        CLINICAL CANCER RESEARCH, Jun. 2004, Peer-reviewed
      • Erratum: Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse (Cancer Cell (4) (437-450))
        S.R. Hingorani; E.F. Petricoin III; A. Maitra; V. Rajapakse; C. King; M.A. Jacobetz; S. Ross; T.P. Conrads; T.D. Veenstra; B.A. Hitt; Y. Kawaguchi; D. Johann; L.A. Liotta; H.C. Crawford; M.E. Putt; T. Jacks; C.V.E. Wright; R.H. Hruban; A.M. Lowy; D.A. Tuveson
        Cancer Cell, 2004, Peer-reviewed
      • Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
        Hingorani, SR; EF Petricoin; A Maitra; Rajapakse, V; C King; MA Jacobetz; S Ross; TP Conrads; TD Veenstra; BA Hitt; Y Kawaguchi; D Johann; LA Liotta; HC Crawford; ME Putt; T Jacks; CVE Wright; RH Hruban; AM Lowy; DA Tuveson
        CANCER CELL, Dec. 2003, Peer-reviewed
      • Increased PDX-1 expression is associated with outcome in patients with pancreatic cancer
        M Koizumi; R Doi; E Toyoda; T Masui; SS Tulachan; Y Kawaguchi; K Fujimoto; GK Gittes; M Imamura
        SURGERY, Aug. 2003, Peer-reviewed
      • All-trans retinoic acid induces differentiation of ducts and endocrine cells by mesenchymal/epithelial interactions in embryonic pancreas
        SS Tulachan; R Doi; Y Kawaguchi; S Tsuji; S Nakajima; T Masui; M Koizumi; E Toyoda; T Mori; D Ito; K Kami; K Fujimoto; M Imamura
        DIABETES, Jan. 2003, Peer-reviewed
      • The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors
        Y Kawaguchi; B Cooper; M Gannon; M Ray; RJ MacDonald; CVE Wright
        NATURE GENETICS, Sep. 2002, Peer-reviewed
      • Differential expression of human spasmolytic polypeptide (trefoil factor family-2) in pancreatic carcinomas, ampullary carcinomas, and mucin-producing tumors of the pancreas
        G Ohshio; H Suwa; Y Kawaguchi; M Imamura; Y Yamaoka; H Yamabe; M Matsumoto; H Yoshioka; Y Hashimoto; H Takeda
        DIGESTIVE DISEASES AND SCIENCES, Apr. 2000, Peer-reviewed
      • A CAG/CTG expansion in the normal population
        M Nakamoto; H Takebayashi; Y Kawaguchi; S Narumiya; M Taniwaki; Y Nakamura; Y Ishikawa; Akiguchi, I; J Kimura; A Kakizuka
        NATURE GENETICS, Dec. 1997, Peer-reviewed
      • Expression of Fas-estrogen receptor fusion protein induces cell death in pancreatic cancer cell lines
        Y Kawaguchi; H Takebayashi; A Kakizuka; S Arii; M Kato; M Imamura
        CANCER LETTERS, Jun. 1997, Peer-reviewed
      • Evaluation of cholecystokinin, gastrin, CCK-A receptor, and CCK-B/gastrin receptor gene expressions in gastric cancer
        N Okada; A Kubota; T Imamura; H Suwa; Y Kawaguchi; G Ohshio; Y Seino; M Imamura
        CANCER LETTERS, Sep. 1996, Peer-reviewed
      • MOLECULAR-FEATURES OF THE CAG REPEATS AND CLINICAL MANIFESTATION OF MACHADO-JOSEPH DISEASE
        H MARUYAMA; S NAKAMURA; Z MATSUYAMA; T SAKAI; M DOYU; G SOBUE; M SETO; M TSUJIHATA; T OHI; T NISHIO; N SUNOHARA; R TAKAHASHI; M HAYASHI; NISHINO, I; T OHTAKE; T ODA; M NISHIMURA; T SAIDA; H MATSUMOTO; M BABA; Y KAWAGUCHI; A KAKIZUKA; H KAWAKAMI
        HUMAN MOLECULAR GENETICS, May 1995, Peer-reviewed
      • UNIQUE FEATURES OF THE CAG REPEATS IN MACHADO-JOSEPH DISEASE
        H KAWAKAMI; H MARUYAMA; S NAKAMURA; Y KAWAGUCHI; A KAKIZUKA; M DOYU; G SOBUE
        NATURE GENETICS, Apr. 1995, Peer-reviewed
      • CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1
        Y. Kawaguchi; T. Okamoto; M. Taniwaki; M. Aizawa; M. Inoue; S. Katayama; H. Kawakami; S. Nakamura; M. Nishimura; I. Akiguchi; J. Kimura; S. Narumiya; A. Kakizuka
        Nature Genetics, Nov. 1994, Peer-reviewed
      • Effect of the intravenous administration of sepinostat mesilate on cerulein induced acute pancreatitis in rats
        Z.-H. Wang; T. Manabe; G. Ohshio; T. Kyogoku; N. Okada; F. Yotsumoto; T. Imamura; K.-I. Yamaki; Y. Kawaguchi; M. Imamura
        Surgical Research Communications, 1994, Peer-reviewed
      • Sequence analysis of cloned cDNA for rat substance P precursor: Existence of a third substance P precursor
        Y. Kawaguchi; M. Hoshimaru; H. Nawa; S. Nakanishi
        Biochemical and Biophysical Research Communications, 1986, Peer-reviewed

      Misc.

      • Resolution of Preoperative Portal Vein Thrombosis After Administration of Antithrombin III in Living Donor Liver Transplantation: Case Report
        H. Imai; H. Egawa; M. Kajiwara; A. Nakajima; Y. Ogura; E. Hatano; M. Ueda; Y. Kawaguchi; T. Kaido; Y. Takada; S. Uemoto
        TRANSPLANTATION PROCEEDINGS, Nov. 2009, Peer-reviewed
      • Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis
        Jennifer P. Morton; Michelle E. Mongeau; David S. Klimstra; John P. Morris; Yie Chia Lee; Yoshiya Kawaguchi; Christopher V. E. Wright; Matthias Hebrok; Brian C. Lewis
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Mar. 2007, Peer-reviewed

      Presentations

      • Cre/loxP を用いた細胞系譜解析法による臓器発生・成体臓器維持機構の解明
        第52回日本組織細胞化学総会学術集会, Sep. 2011, 日本組織細胞化学会
      • 成体肝・膵・腸の維持機構
        第29回日本ヒト細胞学会学術集会, Aug. 2011, 日本ヒト細胞学会
      • 肝臓・膵外分泌・腸管におけるSOX9陽性前駆領域からの持続的細胞供給
        第97回日本消化器病学会総会, May 2011, 日本消化器病学会
      • Continuous cell supply from Sox9-expressing progenitors in adult liver, exocrine pancreas and intestine
        3rd Symposium of the IMSUT and RCAST Global COE, May 2011, 東京大学
      • 臓器形成・機能と幹細胞システム
        JDDW2010, Oct. 2010, JDDW(肝臓学会・消化器病学会)
      • Genetic lineage tracing, a powerful tool to investigate the embryonic organogenesis and adult organ maintenance of the pancreas
        熊本大学グローバルCOEリエゾンラボ研究会, Oct. 2010, 熊本大学
      • Mechanism of pancreatic cell maintenance and its implication in carcinogenesis
        Tokyo Symposium on pancreatic cancer, Aug. 2009, 日本膵臓学会
      • 膵発生に病気の発症メカニズムをもとめて~膵島移植もやってます!~
        第2回先進治療学セミナー, Jun. 2008, 順天堂大学
      • Notchシグナルと異所性膵臓発生
        第51回日本糖尿病学会年次学術総会, May 2008, 日本糖尿病学会

      Awards

      • 04 Feb. 2005
        Cytoprotection 研究会, 奨励賞

      External funds: others

      • 成体肝・膵特異的幹細胞機能維持機構の解明とその破綻による疾患モデルの開発
        最先端次世代研究開発支援プログラム
        From Feb. 2011
        代表
      list
        Last Updated :2022/11/23

        Education

        Teaching subject(s)

        • From Apr. 2011, To Mar. 2012
          Clinical Overview of Surgery II
          Fall, 医学部(人間健康科学科)
        • From Apr. 2012, To Mar. 2013
          Clinical Overview of Surgery II
          Fall, 医学部(人間健康科学科)
        • From Apr. 2013, To Mar. 2014
          Clinical Overview of Surgery II
          Fall, 医学部(人間健康科学科)
        • From Apr. 2014, To Mar. 2015
          Clinical Overview of Surgery II
          Fall, 医学部(人間健康科学科)
        • From Apr. 2015, To Mar. 2016
          Clinical Overview of Surgery II
          Fall, 医学部(人間健康科学科)
        • From Apr. 2010, To Mar. 2011
          Gastroenterology and mark Hepatology
          Spring, 医学部(医学科)
        • From Apr. 2011, To Mar. 2012
          Gastroenterology and mark Hepatology
          Spring, 医学部(医学科)
        • From Apr. 2012, To Mar. 2013
          Gastroenterology and mark Hepatology
          Spring, 医学部(医学科)
        • From Apr. 2013, To Mar. 2014
          Gastroenterology and mark Hepatology
          Spring, 医学部(医学科)
        • From Apr. 2014, To Mar. 2015
          Gastroenterology and mark Hepatology
          Spring, 医学部(医学科)
        • From Apr. 2015, To Mar. 2016
          Gastroenterology and mark Hepatology
          Spring, 医学部(医学科)
        • From Apr. 2016, To Mar. 2017
          Clinical Overview of Surgery II
          Fall, 医学部(人間健康科学科)
        • From Apr. 2017, To Mar. 2018
          Clinical Overview of Surgery II
          Fall, 医学部(人間健康科学科)

        Participation in PhD Defense

        • Post-transplant lymphoproliferative disorders after liver transplantation: A retrospective cohort study including 1,954 transplants
          TAJIMA TETSUYA, Graduate School of Medicine, Sub-chief Examiner
          26 Jul. 2021
        • Brg1 is required to maintain colorectal cancer stem cells
          YOSHIKAWA TAKAAKI, Graduate School of Medicine, Chief Examiner
          23 Mar. 2022
        • Prevascularization-free Primary Subcutaneous Transplantation of Xenogeneic Islets Co-encapsulated with Hepatocyte Growth Factor
          YANG, SIN-YU, Graduate School of Medicine, Chief Examiner
          24 May 2021
        • MYCL promotes iPSC-like colony formation via MYC Box 0 and 2 domains
          AKIFUJI CHIAKI, Graduate School of Medicine, Chief Examiner
          23 Mar. 2022
        • Increased expression of programmed cell death ligand 1 and galectin 9 in transplant recipients who achieved tolerance after immunosuppression withdrawal
          NGUYEN HAI NAM, Graduate School of Medicine, Sub-chief Examiner
          23 Mar. 2022
        • Capturing human trophoblast development with naive pluripotent stem cells in vitro
          IO SHINGO, Graduate School of Medicine, Chief Examiner
          24 Nov. 2021
        • Core-shell hydrogel microfiber-expanded pluripotent stem cell-derived lung progenitors applicable to lung reconstruction in vivo
          IKEO SATOSHI, Graduate School of Medicine, Sub-chief Examiner
          24 Jan. 2022
        • DNA methyltransferase 3B plays a protective role against hepatocarcinogenesis caused by chronic inflammation via maintaining mitochondrial homeostasis
          IGUCHI ERIKO, Graduate School of Medicine, Sub-chief Examiner
          26 Jul. 2021
        • Bolus Administration of Polyamines Boosts Effects on Hepatic Ischemia-Reperfusion Injury and Regeneration in Rats
          DOI JUNSHI, Graduate School of Medicine, Chief Examiner
          24 Nov. 2021
        • Carbonic anhydrase 8 (CAR8) negatively regulates GLP-1 secretion from enteroendocrine cells in response to long-chain fatty acids
          FUJIWARA YUTA, Graduate School of Medicine, Sub-chief Examiner
          26 Jul. 2021
        • Visualization of stem cell activity in pancreatic cancer expansion by direct lineage tracing with live imaging
          MARUNO TAKAHISA, Graduate School of Medicine, Sub-chief Examiner
          26 Jul. 2021
        list
          Last Updated :2022/11/23

          Administration

          Faculty management (title, position)

          • From 01 Apr. 2022, To 31 Mar. 2025
            医学部附属病院 先端医療研究開発機構 先制医療・生活習慣病研究センター評価委員会
          • From 01 Apr. 2020, To 31 Mar. 2024
            共通機器管理運営委員会1号委員、副委員長
          • From 01 Jun. 2011
            医学・病院地区FACS委員会
          • From 01 Apr. 2017, To 31 Mar. 2024
            京都大学ウイルス・再生医科学研究所医の倫理委員会
          • From 01 Apr. 2016, To 31 Mar. 2017
            京都大学再生医科学研究所、物質ー細胞統合システム拠点およびiPS細胞研究所合同医の倫理委員会
          • From 01 Nov. 2018
            医学研究科カリキュラム検討WG
          • From 01 Apr. 2020, To 31 Mar. 2024
            財務委員会2号委員
          • From 23 Jan. 2020, To 31 Mar. 2023
            動物実験施設運営委員会2号委員

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