Basic Information

Affiliated programs (koza)

• Graduate School of Medicine, 医学専攻 臓器形成誘導, 教授
• Graduate School of Medicine, 医科学専攻 臓器形成誘導, 教授

Faculty

• 医学部

Concurrent Affiliation

• Center for iPS Cell Research and Application (CiRA), iPS細胞研究所 未来生命科学開拓部門, 教授

Academic Degree

• 医学博士(京都大学)

ID,URL

• J-Global ID

  200901035089620062

researchmap URL

• https://researchmap.jp/read0095827

Research

Research Topics, Overview of the research

• Research Topics

  Understanding the molecular mechanism in organogenesis, regeneration and cancer of endodermal organ

• Overview of the research

  We try to deepen our understanding in the regulatory mechanism of cell behavior in the three dimentional structure of endodermal organ using transgenic mouse models and in vitro experiments. Especially, we focus on the similarity and difference in the cell behavior among organogenesis, regeneration and cancer.

Papers

• Autophagy Inhibition on In Vitro and In Vivo PanNET Models

  Nakano Kenzo; Masui Toshihiko; Yogo Akitada; Uchida Yuichiro; Nagai Kazuyuki; Anazawa Takayuki; Takaori Kyoichi; Kawaguchi Yoshiya; Uemoto Shinji

  PANCREAS, Mar. 2019, Peer-reviewed

  
• Exocrine tissue-driven TFF2 prevents apoptotic cell death of endocrine lineage during pancreas organogenesis.

  Koji Hirata; Sota Kodama; Yasuhiro Nakano; Yasuko Minaki-Nakagawa; Yoshiki Aoyama; Morito Sakikubo; Toshihiko Goto; Masahiro Yoshida; Toshihiko Masui; Takuya Yamamoto; Shinji Uemoto; Yoshiya Kawaguchi

  Scientific reports, 07 Feb. 2019, Peer-reviewed

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• In vivo reprogramming drives Kras-induced cancer development

  Hirofumi Shibata; Shingo Komura; Yosuke Yamada; Nao Sankoda; Akito Tanaka; Tomoyo Ukai; Mio Kabata; Satoko Sakurai; Bunya Kuze; Knut Woltjen; Hironori Haga; Yatsuji Ito; Yoshiya Kawaguchi; Takuya Yamamoto; Yasuhiro Yamada

  Nature Communications, 01 Dec. 2018, Peer-reviewed

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• Ptf1a inactivation in adult pancreatic acinar cells causes apoptosis through activation of the endoplasmic reticulum stress pathway.

  Morito Sakikubo; Kenichiro Furuyama; Masashi Horiguchi; Shinichi Hosokawa; Yoshiki Aoyama; Kunihiko Tsuboi; Toshihiko Goto; Koji Hirata; Toshihiko Masui; Yuval Dor; Tomoyuki Fujiyama; Mikio Hoshino; Shinji Uemoto; Yoshiya Kawaguchi

  Scientific reports, 25 Oct. 2018, Peer-reviewed

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• Forebrain Ptf1a Is Required for Sexual Differentiation of the Brain

  Tomoyuki Fujiyama; Satoshi Miyashita; Yousuke Tsuneoka; Kazumasa Kanemaru; Miyo Kakizaki; Satomi Kanno; Yukiko Ishikawa; Mariko Yamashita; Tomoo Owa; Mai Nagaoka; Yoshiya Kawaguchi; Yuchio Yanagawa; Mark A. Magnuson; Masafumi Muratani; Akira Shibuya; Yo-ichi Nabeshima; Masashi Yanagisawa; Hiromasa Funato; Mikio Hoshino

  Cell Reports, 03 Jul. 2018, Peer-reviewed

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• Comparison of Recurrence Between Pancreatic and Duodenal Neuroendocrine Neoplasms After Curative Resection: A Single-Institution Analysis

  Toshihiko Masui; Asahi Sato; Kenzo Nakano; Yuichiro Uchida; Akitada Yogo; Takayuki Anazawa; Kazuyuki Nagai; Yoshiya Kawaguchi; Kyoichi Takaori; Shinji Uemoto

  Annals of Surgical Oncology, 01 Feb. 2018, Peer-reviewed

  
• A Prospective Study of Intensity-modified Radiation Therapy in Comparison with Conventional 3D-RT for BR Pancreatic Cancer Patients with Arterial Involvement

  Toshihiko Masui; Kyoichi Takaori; Takayuki Anazawa; Asahi Sato; Kenzo Nakano; Yuichiro Uchida; Akitada Yogo; Yoko Goto; Shigemi Matsumoto; Yuzo Kodama; Masashi Kanai; Hiroyoshi Isoda; Masaki Mizumoto; Yoshiya Kawaguchi; Keiko Shibuya; Satoshi Itasaka; Shinji Uemoto

  ANTICANCER RESEARCH, Dec. 2017, Peer-reviewed

  
• A case of successful conversion from everolimus to surgical resection of a giant pancreatic neuroendocrine tumor

  Sato Asahi; Masui Toshihiko; Sankoda Nao; Nakano Kenzo; Uchida Yuichiro; Anazawa Takayuki; Takaori Kyoichi; Kawaguchi Yoshiya; Uemoto Shinji

  SURGICAL CASE REPORTS, 20 Jul. 2017, Peer-reviewed

  
• Abdominal contamination with Candida albicans after pancreaticoduodenectomy is related to hemorrhage associated with pancreatic fistulas

  Asahi Sato; Toshihiko Masui; Kenzo Nakano; Nao Sankoda; Takayuki Anazawa; Kyoichi Takaori; Yoshiya Kawaguchi; Shinji Uemoto

  PANCREATOLOGY, May 2017, Peer-reviewed

  
• Liver-specific Prox1 inactivation causes hepatic injury and glucose intolerance in mice

  Toshihiko Goto; Ashraf Elbahrawy; Kenichiro Furuyama; Masashi Horiguchi; Shinichi Hosokawa; Yoshiki Aoyama; Kunihiko Tsuboi; Morito Sakikubo; Koji Hirata; Toshihiko Masui; Hajime Kubo; Yoshiharu Sakai; Shinji Uemoto; Yoshiya Kawaguchi

  FEBS LETTERS, Feb. 2017, Peer-reviewed

  
• Concurrent gemcitabine+S-1 neoadjuvant chemotherapy contributes to the improved survival of patients with small borderline-resectable pancreatic cancer tumors

  Toshihiko Masui; Ryuichiro Doi; Yoshiya Kawaguchi; Asahi Sato; Kenzo Nakano; Tatsuo Ito; Takayuki Anazawa; Kyoichi Takaori; Shinji Uemoto

  SURGERY TODAY, Nov. 2016, Peer-reviewed

  
• Nardilysin Is Required for Maintaining Pancreatic beta-Cell Function

  Kiyoto Nishi; Yuichi Sato; Mikiko Ohno; Yoshinori Hiraoka; Sayaka Saijo; Jiro Sakamoto; Po-Min Chen; Yusuke Morita; Shintaro Matsuda; Kanako Iwasaki; Kazu Sugizaki; Norio Harada; Yoshiko Mukumoto; Hiroshi Kiyonari; Kenichiro Furuyama; Yoshiya Kawaguchi; Shinji Uemoto; Toru Kita; Nobuya Inagaki; Takeshi Kimura; Eiichiro Nishi

  DIABETES, Oct. 2016, Peer-reviewed

  
• Concomitant Case of Intraductal Papillary Mucinous Neoplasm of the Pancreas and Functioning Pancreatic Neuroendocrine Tumor (Vasoactive Intestinal Polypeptide-Producing Tumor) First Report

  Shoko Ishizu; Takeshi Setoyama; Taro Ueo; Yoshihide Ueda; Yuzo Kodama; Hiroshi Ida; Yoshiya Kawaguchi; Akihiko Yoshizawa; Tsutomu Chiba; Shin'ichi Miyamoto

  PANCREAS, Jul. 2016, Peer-reviewed

  
• SOX9 is a novel cancer stem cell marker surrogated by osteopontin in human hepatocellular carcinoma

  Takayuki Kawai; Kentaro Yasuchika; Takamichi Ishii; Yuya Miyauchi; Hidenobu Kojima; Ryoya Yamaoka; Hokahiro Katayama; Elena Yukie Yoshitoshi; Satoshi Ogiso; Sadahiko Kita; Katsutaro Yasuda; Ken Fukumitsu; Junji Komori; Etsuro Hatano; Yoshiya Kawaguchi; Shinji Uemoto

  SCIENTIFIC REPORTS, Jul. 2016, Peer-reviewed

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• Origins of oligodendrocytes in the cerebellum, whose development is controlled by the transcription factor, Sox9

  Ryoya Hashimoto; Kei Hori; Tomoo Owa; Satoshi Miyashita; Kenichi Dewa; Norihisa Masuyama; Kazuhisa Sakai; Yoneko Hayase; Yusuke Seto; Yukiko U. Inoue; Takayoshi Inoue; Noritaka Ichinohe; Yoshiya Kawaguchi; Haruhiko Akiyama; Schuichi Koizumi; Mikio Hoshino

  MECHANISMS OF DEVELOPMENT, May 2016, Peer-reviewed

  
• Proteasome activity is required for the initiation of precancerous pancreatic lesions

  Takaki Furuyama; Shinji Tanaka; Shu Shimada; Yoshimitsu Akiyama; Satoshi Matsumura; Yusuke Mitsunori; Arihiro Aihara; Daisuke Ban; Takanori Ochiai; Atsushi Kudo; Hiroshi Fukamachi; Shigeki Arii; Yoshiya Kawaguchi; Minoru Tanabe

  SCIENTIFIC REPORTS, May 2016, Peer-reviewed

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• Diabetes Caused by Elastase-Cre-Mediated Pdx1 Inactivation in Mice

  Sota Kodama; Yasuhiro Nakano; Koji Hirata; Kenichiro Furuyama; Masashi Horiguchi; Takeshi Kuhara; Toshihiko Masui; Michiya Kawaguchi; Maureen Gannon; Christopher V. E. Wright; Shinji Uemoto; Yoshiya Kawaguchi

  SCIENTIFIC REPORTS, Feb. 2016, Peer-reviewed

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• Spatiotemporal regulation of neural progenitor identities by transcription factors

  Mikio Hoshino; Yusuke Seto; Tomoya Nakatani; Yoshiya Kawaguchi; Kazuhiro Ikenaka; Hirohide Takebayashi; Yuichi Ono; Mayumi Yamada

  INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, Dec. 2015, Peer-reviewed

  
• A case report of a type 1 diabetes patient maintaining C-peptide secretion for ten years after islet transplantation using donation after cardiocirculatory death (DCD) donors

  Yasuhiro Iwanaga; Shinichi Matsumoto; Teru Okitsu; Hideo Nagata; Hirofumi Noguchi; Yukihide Yonekawa; Michiya Kawaguchi; Takayuki Anazawa; Yoshiya Kawaguchi; Hideaki Okajima; Shinji Uemoto

  XENOTRANSPLANTATION, Nov. 2015, Peer-reviewed

  
• A CASE REPORT OF A TYPE 1 DIABETES PATIENT MAINTAINING C-PEPTIDE SECRETION FOR TEN YEARS AFTER ISLET TRANSPLANTATION USING DONATION AFTER CARDIOCIRCULATORY DEATH (DCD) DONORS.

  Yasuhiro Iwanaga; Shinichi Matsumoto; Teru Okitsu; Hideo Nagata; Hirofumi Noguchi; Yukihide Yonekawa; Michiya Kawaguchi; Takayuki Anazawa; Yoshiya Kawaguchi; Hideaki Okajima; Shinji Uemoto

  TRANSPLANTATION, Nov. 2015, Peer-reviewed

  
• Disappearance of centroacinar cells in the Notch ligand-deficient pancreas

  Yasuhiro Nakano; Naoko Negishi; Seiho Gocho; Tetsuya Mine; Yuri Sakurai; Masaki Yazawa; Koichiro Abe; Hideo Yagita; Sonoko Habu; Ryoichiro Kageyama; Yoshiya Kawaguchi; Katsuto Hozumi

  GENES TO CELLS, Jun. 2015, Peer-reviewed

  
• Cell aggregation optimizes the differentiation of human ESCs and iPSCs into pancreatic bud-like progenitor cells

  Taro Toyoda; Shin-Ichi Mae; Hiromi Tanaka; Yasushi Kondo; Michinori Funato; Yoshiya Hosokawa; Tomomi Sudo; Yoshiya Kawaguchi; Kenji Osafune

  STEM CELL RESEARCH, Mar. 2015, Peer-reviewed

  
• Impact of Sox9 Dosage and Hes1-mediated Notch Signaling in Controlling the Plasticity of Adult Pancreatic Duct Cells in Mice

  Shinichi Hosokawa; Kenichiro Furuyama; Masashi Horiguchi; Yoshiki Aoyama; Kunihiko Tsuboi; Morito Sakikubo; Toshihiko Goto; Koji Hirata; Wataru Tanabe; Yasuhiro Nakano; Haruhiko Akiyama; Ryoichiro Kageyama; Shinji Uemoto; Yoshiya Kawaguchi

  SCIENTIFIC REPORTS, Feb. 2015, Peer-reviewed

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• Activation of GLP-1 and Gastrin Signaling Induces beta-Cell Neogenesis

  Shugo Sasaki; Takeshi Miyatsuka; Mitsuyoshi Takahara; Fumiyo Kubo; Kazuyuki Miyashita; Yuichi Yamamoto; Tetsuyuki Yasuda; Yoshiya Kawaguchi; Haruhiko Akiyama; Hideaki Kaneto; Taka-Aki Matsuoka; Hirotaka Watada; Iichiro Shimomura

  DIABETES, Jun. 2014, Peer-reviewed

  
• Comparative Outcomes Between Initially Unresectable and Recurrent Cases of Advanced Pancreatic Cancer Following Palliative Chemotherapy

  Peng Xue; Masashi Kanai; Yukiko Mori; Takafumi Nishimura; Norimitsu Uza; Yuzo Kodama; Yoshiya Kawaguchi; Kyoichi Takaori; Shigemi Matsumoto; Shinji Uemoto; Tsutomu Chiba

  PANCREAS, Apr. 2014, Peer-reviewed

  
• Specification of Spatial Identities of Cerebellar Neuron Progenitors by Ptf1a and Atoh1 for Proper Production of GABAergic and Glutamatergic Neurons

  Mayumi Yamada; Yusuke Seto; Shinichiro Taya; Tomoo Owa; Yukiko U. Inoue; Takayoshi Inoue; Yoshiya Kawaguchi; Yo-ichi Nabeshima; Mikio Hoshino

  JOURNAL OF NEUROSCIENCE, Apr. 2014, Peer-reviewed

  
• Neutrophil-to-lymphocyte ratio for predicting palliative chemotherapy outcomes in advanced pancreatic cancer patients

  Peng Xue; Masashi Kanai; Yukiko Mori; Takafumi Nishimura; Norimitsu Uza; Yuzo Kodama; Yoshiya Kawaguchi; Kyoichi Takaori; Shigemi Matsumoto; Shinji Uemoto; Tsutomu Chiba

  CANCER MEDICINE, Apr. 2014, Peer-reviewed

  
• Radiotherapy for patients with isolated local recurrence of primary resected pancreatic cancer - Prolonged disease-free interval associated with favorable prognosis

  A. Nakamura; S. Itasaka; K. Takaori; Y. Kawaguchi; K. Shibuya; M. Yoshimura; Y. Matsuo; T. Mizowaki; S. Uemoto; M. Hiraoka

  Strahlentherapie und Onkologie, Apr. 2014, Peer-reviewed

  
• Temporal identity transition from Purkinje cell progenitors to GABAergic interneuron progenitors in the cerebellum

  Yusuke Seto; Tomoya Nakatani; Norihisa Masuyama; Shinichiro Taya; Minoru Kumai; Yasuko Minaki; Akiko Hamaguchi; Yukiko U. Inoue; Takayoshi Inoue; Satoshi Miyashita; Tomoyuki Fujiyama; Mayumi Yamada; Heather Chapman; Kenneth Campbell; Mark A. Magnuson; Christopher V. Wright; Yoshiya Kawaguchi; Kazuhiro Ikenaka; Hirohide Takebayashi; Shin'ichi Ishiwata; Yuichi Ono; Mikio Hoshino

  NATURE COMMUNICATIONS, Feb. 2014, Peer-reviewed

  
• Expression of SOX9 in Intraductal Papillary Mucinous Neoplasms of the Pancreas

  Fanbin Meng; Kyoichi Takaori; Tatsuo Ito; Toshihiko Masui; Michiya Kawaguchi; Yoshiya Kawaguchi; Shinji Uemoto

  PANCREAS, Jan. 2014, Peer-reviewed

  
• CAPS1 Deficiency Perturbs Dense-Core Vesicle Trafficking and Golgi Structure and Reduces Presynaptic Release Probability in the Mouse Brain

  Tetsushi Sadakata; Wataru Kakegawa; Yo Shinoda; Mayu Hosono; Ritsuko Katoh-Semba; Yukiko Sekine; Yumi Sato; Mika Tanaka; Takuji Iwasato; Shigeyoshi Itohara; Kenichiro Furuyama; Yoshiya Kawaguchi; Yasuki Ishizaki; Michisuke Yuzaki; Teiichi Furuichi

  JOURNAL OF NEUROSCIENCE, Oct. 2013, Peer-reviewed

  
• Sox9 and programming of liver and pancreatic progenitors

  Yoshiya Kawaguchi

  JOURNAL OF CLINICAL INVESTIGATION, May 2013, Peer-reviewed

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• Dclk1 distinguishes between tumor and normal stem cells in the intestine

  Y. Nakanishi; H. Seno; A. Fukuoka; T. Ueo; Y. Yamaga; T. Maruno; N. Nakanishi; K. Kanda; H. Komekado; M. Kawada; A. Isomura; K. Kawada; Y. Sakai; M. Yanagita; R. Kageyama; Y. Kawaguchi; M.M. Taketo; S. Yonehara; T. Chiba

  Nature Genetics, 2013, Peer-reviewed

  
• GPR119 expression in normal human tissues and islet cell tumors: Evidence for its islet-gastrointestinal distribution, expression in pancreatic beta and alpha cells, and involvement in islet function

  Shinji Odori; Kiminori Hosoda; Tsutomu Tomita; Junji Fujikura; Toru Kusakabe; Yoshiya Kawaguchi; Ryuichiro Doi; Kyoichi Takaori; Ken Ebihara; Yoshiharu Sakai; Shinji Uemoto; Kazuwa Nakao

  Metabolism: Clinical and Experimental, Jan. 2013, Peer-reviewed

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• Dclk1 distinguishes between tumor and normal stem cells in the intestine

  Yuki Nakanishi; Hiroshi Seno; Ayumi Fukuoka; Taro Ueo; Yuichi Yamaga; Takahisa Maruno; Naoko Nakanishi; Keitaro Kanda; Hideyuki Komekado; Mayumi Kawada; Akihiro Isomura; Kenji Kawada; Yoshiharu Sakai; Motoko Yanagita; Ryoichiro Kageyama; Yoshiya Kawaguchi; Makoto M. Taketo; Shin Yonehara; Tsutomu Chiba

  NATURE GENETICS, Jan. 2013, Peer-reviewed

  
• Delayed gastric emptying improved by straight stomach reconstruction with twisted anastomosis to the jejunum after pylorus-preserving pancreaticoduodenectomy (PPPD) in 118 consecutive patients at a single institution

  Toshihiko Masui; Ryuchiro Doi; Yoshiya Kawaguchi; Shinji Uemoto

  SURGERY TODAY, May 2012, Peer-reviewed

  
• Definitive radiotherapy for patients with isolated local recurrence of primary resected pancreatic cancer: A retrospective analysis.

  Akira Nakamura; Keiko Shibuya; Kyoichi Takaori; Yoshiya Kawaguchi; Michio Yoshimura; Yukinori Matsuo; Satoshi Itasaka; Masahiro Hiraoka

  JOURNAL OF CLINICAL ONCOLOGY, Feb. 2012, Peer-reviewed

  
• Successful Neoadjuvant Treatment with Radiochemotherapy and Systemic Chemotherapy for the Locally Advanced Pancreatic Head Cancer: Report of a Case

  Toshihiko Masui; Ryuichiro Doi; Kohei Ogawa; Kazuhiro Kami; Takafumi Machimoto; Satoru Seo; Yoshiya Kawaguchi; Hiroto Egawa; Yasuhiro Matsugu; Shinji Uemoto

  HEPATO-GASTROENTEROLOGY, Sep. 2011, Peer-reviewed

  
• In vitro generation of insulin-secreting cells from human pancreatic exocrine cells

  Kohtaro Minami; Ryuichiro Doi; Yoshiya Kawaguchi; Daiki Nukaya; Yoshiaki Hagiwara; Hirofumi Noguchi; Shinichi Matsumoto; Susumu Seino

  JOURNAL OF DIABETES INVESTIGATION, Aug. 2011, Peer-reviewed

  
• A phase I/II study of gemcitabine-based chemotherapy plus curcumin for patients with gemcitabine-resistant pancreatic cancer

  Masashi Kanai; Kenichi Yoshimura; Masanori Asada; Atsushi Imaizumi; Chihiro Suzuki; Shigemi Matsumoto; Takafumi Nishimura; Yukiko Mori; Toshihiko Masui; Yoshiya Kawaguchi; Kazuhiro Yanagihara; Shujiro Yazumi; Tsutomu Chiba; Sushovan Guha; Bharat B. Aggarwal

  CANCER CHEMOTHERAPY AND PHARMACOLOGY, Jul. 2011, Peer-reviewed

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• A Case of Progressive Digital Ischemia after Early Withdrawal of Gemcitabine and S-1 in a Patient with Systemic Sclerosis

  C. Zaima; M. Kanai; S. Ishikawa; Y. Kawaguchi; T. Masui; Y. Mori; T. Nishimura; S. Matsumoto; K. Yanagihara; T. Chiba; T. Mimori

  JAPANESE JOURNAL OF CLINICAL ONCOLOGY, Jun. 2011, Peer-reviewed

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• Adenoendocrine cell carcinoma of the extrahepatic bile duct: A case report and review of the literature

  Toshihiko Masui; Ryuichiro Doi; Yoshiya Kawaguchi; Yasuhiro Iwanaga; Tatsuo Ito; Masayuki Koizumi; Shinji Uemoto

  Clinical Journal of Gastroenterology, Jun. 2011, Peer-reviewed

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• RBP-J promotes the maturation of neuronal progenitors

  Okiru Komine; Mai Nagaoka; Yuichi Hiraoka; Mikio Hoshino; Yoshiya Kawaguchi; Warren S. Pear; Kohichi Tanaka

  DEVELOPMENTAL BIOLOGY, Jun. 2011, Peer-reviewed

  
• Thrombotic microangiopathy-like disorder after living-donor liver transplantation: A single-center experience in Japan

  Tomohide Hori; Toshimi Kaido; Fumitaka Oike; Yasuhiro Ogura; Kohei Ogawa; Yukihide Yonekawa; Koichiro Hata; Yoshiya Kawaguchi; Mikiko Ueda; Akira Mori; Hajime Segawa; Kimiko Yurugi; Yasutsugu Takada; Hiroto Egawa; Atsushi Yoshizawa; Takuma Kato; Kanako Saito; Linan Wang; Mie Torii; Feng Chen; Ann-Marie T. Baine; Lindsay B. Gardner; Shinji Uemoto

  WORLD JOURNAL OF GASTROENTEROLOGY, Apr. 2011, Peer-reviewed

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• The distribution of atypical epithelium in main-duct type intraductal papillary mucinous neoplasms of the pancreas

  Tatsuo Ito; Ryuichiro Doi; Akihiko Yoshizawa; Morito Sakikubo; Kazuyuki Nagai; Atsushi Kida; Masayuki Koizumi; Toshihiko Masui; Yoshiya Kawaguchi; Toshiaki Manabe; Shinji Uemoto

  JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES, Mar. 2011, Peer-reviewed

  
• Genetic studies on the development and function of the hypothalamus using Ptf1a-Cre & -flox knock-in mice

  Tomoyuki Fujiyama; Mai Nagaoka; Yuchio Yanagawa; Mark Magnuson; Kunihiko Obata; Yoshiya Kawaguchi; Yo-ichi Nabeshima; Mikio Hoshino

  NEUROSCIENCE RESEARCH, 2011, Peer-reviewed

  
• Noninvasive Intraductal Papillary Mucinous Neoplasm with Para-Aortic Lymph Node Metastasis: Report of a Case

  Kazuyuki Nagai; Ryuichiro Doi; Masayuki Koizumi; Toshihiko Masui; Yoshiya Kawaguchi; Akihiko Yoshizawa; Shinji Uemoto

  SURGERY TODAY, Jan. 2011, Peer-reviewed

  
• Genetic lineage tracing, a powerful tool to investigate the embryonic organogenesis and adult organ maintenance of the pancreas

  Yoshiya Kawaguchi; Kyoichi Takaori; Shinji Uemoto

  JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES, Jan. 2011, Peer-reviewed

  
• Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine

  Kenichiro Furuyama; Yoshiya Kawaguchi; Haruhiko Akiyama; Masashi Horiguchi; Sota Kodama; Takeshi Kuhara; Shinichi Hosokawa; Ashraf Elbahrawy; Tsunemitsu Soeda; Masayuki Koizumi; Toshihiko Masui; Michiya Kawaguchi; Kyoichi Takaori; Ryuichiro Doi; Eiichiro Nishi; Ryosuke Kakinoki; Jian Min Deng; Richard R. Behringer; Takashi Nakamura; Shinji Uemoto

  NATURE GENETICS, Jan. 2011, Peer-reviewed

  
• Laparoscopic common hepatic artery ligation and staging followed by distal pancreatectomy with en bloc resection of celiac artery for advanced pancreatic cancer.

  V. Raut; K. Takaori; Y. Kawaguchi; M. Mizumoto; M. Kawaguchi; M. Koizumi; S. Kodama; A. Kida; S. Uemoto

  Asian journal of endoscopic surgery, 2011, Peer-reviewed

  
• Usefullness of Selective Arterial Secretagogue Injection Test by Calcium for Diagnosis of Pancreatic Gastrinoma: A Case Report

  Naoko Kamo; Ryuichiro Doi; Hisashi Imai; Toshihiko Masui; Yasuhiro Iwanaga; Yoshiya Kawaguchi; Yasutsugu Takada; Noritsugu Ohashi; Shinji Uemoto

  PANCREAS, Jul. 2010, Peer-reviewed

  
• Adenosquamous Carcinoma of the Pancreas With the Special Feature of Strong Uptake on FDG-PET

  Tatsuo Itoh; Ryuichiro Doi; Yuji Nakamoto; Hiroshi Takahashi; Toshihiko Masui; Hisashi Imai; Naoko Kamo; Yasuhiro Iwanaga; Yoshiya Kawaguchi; Yasutsugu Takada; Shinji Uemoto

  PANCREAS, Jul. 2010, Peer-reviewed

  
• Coupled regulation of interleukin-12 receptor beta-1 of CD8+central memory and CCR7-negative memory T cells in an early alloimmunity in liver transplant recipients

  H. Egawa; K. Ozawa; Y. Takada; S. Teramukai; A. Mori; K. Ogawa; T. Kaido; Y. Fujimoto; Y. Kawaguchi; E. Hatano; H. Sato; M. Ono; K. Takai; K. Tanaka; S. Uemoto

  CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Jun. 2010, Peer-reviewed

  
• Preoperative assessment of para-aortic lymph node metastasis in patients with pancreatic cancer

  Hisashi Imai; Ryuichiro Doi; Hiroyuki Kanazawa; Naoko Kamo; Masayuki Koizumi; Toshihiko Masui; Yasuhiro Iwanaga; Yoshiya Kawaguchi; Yasutsugu Takada; Hiroyoshi Isoda; Shinji Uemoto

  INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, Jun. 2010, Peer-reviewed

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• Physiological roles of the Hes1 in the pancreas

  Junji Fujikura; Masaki Naito; Kiminori Hosoda; Hiroshi Iwakura; Tsutomu Tomita; Michio Noguchi; Shinji Odori; Eisaku Mori; Chisako Kozuka; Yuji Yamamoto; Ken Ebihara; Hiroaki Masuzaki; Yoshiya Kawaguchi; Rhoichiro Kageyama; Kazuwa Nakao

  ENDOCRINE JOURNAL, Mar. 2010, Peer-reviewed

  
• Function and mutual expression control of bHLH transcription factors, Ptf1a and Atoh1, in the developing cerebellum

  Mayumi Yamada; Shinichiro Taya; Tomoo Owa; Yoshiya Kawaguchi; Yo-ichi Nabeshima; Mikio Hoshino

  NEUROSCIENCE RESEARCH, 2010, Peer-reviewed

  
• Ptf1a Directly Controls Expression of Immunoglobulin Superfamily Molecules Nephrin and Neph3 in the Developing Central Nervous System

  Kazuhiko Nishida; Mikio Hoshino; Yoshiya Kawaguchi; Fujio Murakami

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 2010, Peer-reviewed

  
• Premedication with 20 mg dexamethasone effectively prevents relapse of extensive skin rash associated with gemcitabine monotherapy

  M. Kanai; S. Matsumoto; T. Nishimura; Y. Matsumura; E. Hatano; A. Mori; T. Masui; Y. Kawaguchi; E. Nakamura; S. Tada; T. Kitano; H. Ishiguro; K. Yanagihara; T. Chiba

  ANNALS OF ONCOLOGY, Jan. 2010, Peer-reviewed

  
• Stringent Specificity in the Construction of a GABAergic Presynaptic Inhibitory Circuit

  J. Nicholas Betley; Christopher V. E. Wright; Yoshiya Kawaguchi; Ferenc Erdelyi; Gabor Szabo; Thomas M. Jessell; Julia A. Kaltschmidt

  CELL, Oct. 2009, Peer-reviewed

  
• Kyoto islet isolation method allows efficient islet retrieval from young donor pancreas for clinical use

  Yasuhiro Iwanaga; Shinichi Matsumoto; Hirohumi Noguchi; Teru Okitsu; Yoshiya Kawaguchi; Shinji Uemoto

  XENOTRANSPLANTATION, Sep. 2009, Peer-reviewed

  
• Inhibitory and excitatory subtypes of cochlear nucleus neurons are defined by distinct bHLH transcription factors, Ptf1a and Atoh1

  Tomoyuki Fujiyama; Mayumi Yamada; Mami Terao; Toshio Terashima; Hiroyuki Hioki; Yukiko U. Inoue; Takayoshi Inoue; Norihisa Masuyama; Kunihiko Obata; Yuchio Yanagawa; Yoshiya Kawaguchi; Yo-ichi Nabeshima; Mikio Hoshino

  DEVELOPMENT, Jun. 2009, Peer-reviewed

  
• Single-institution validation of the international consensus guidelines for treatment of branch duct intraductal papillary mucinous neoplasms of the pancreas

  Kazuyuki Nagai; Ryuichiro Doi; Tatsuo Ito; Atsushi Kida; Masayuki Koizumi; Toshihiko Masui; Yoshiya Kawaguchi; Kohei Ogawa; Shinji Uemoto

  JOURNAL OF HEPATO-BILIARY-PANCREATIC SURGERY, May 2009, Peer-reviewed

  
• Prognostic value of metastin expression in human pancreatic cancer

  Kazuyuki Nagai; Ryuichiro Doi; Fumihiko Katagiri; Tatsuo Ito; Atsushi Kida; Masayuki Koizumi; Toshihiko Masui; Yoshiya Kawaguchi; Kenji Tomita; Shinya Oishi; Nobutaka Fujii; Shinji Uemoto

  JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, Jan. 2009, Peer-reviewed

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• Reduction of Ptf1a gene dosage causes pancreatic hypoplasia and diabetes in mice

  Akihisa Fukuda; Yoshiya Kawaguchi; Kenichiro Furuyama; Sota Kodama; Masashi Horiguchi; Takeshi Kuhara; Michiya Kawaguchi; Mami Terao; Ryuichiro Doi; Christopher V. E. Wright; Mikio Hoshino; Tsutomu Chiba; Shinji Uemoto

  DIABETES, Sep. 2008, Peer-reviewed

  
• Combined chemotherapy with S-1 and gemcitabine induced duodenal penetration of pancreatic head cancer: Report of a case

  Masaharu Tada; Ryuichiro Doi; Kazuhiro Kami; Kohei Ogawa; Yoshiya Kawaguchi; Hiroto Egawa; Shinji Uemoto

  PANCREAS, Jul. 2008, Peer-reviewed

  
• GABA and synaptic inhibition of mouse cerebellum lacking glutamate decarboxylase 67

  Kunihiko Obata; Moritoshi Hirono; Nobuko Kume; Yoshiya Kawaguchi; Shigeyoshi Itohara; Yuchio Yanagawa

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jun. 2008, Peer-reviewed

  
• Use of acetaminophen during mixed meal testing to assess the effect of exenatide on gastric emptying in islet transplant recipients

  Teru Okitsu; Yasuhiro Iwanaga; Yoshiya Kawaguchi; Michiya Kawaguchi; Kentaro Toyoda; Hirohumi Noguchi; Hideo Nagata; Yukihide Yonekawa; Nobuya Inagaki; Shinichi Matsumoto; Shinji Uemoto

  AMERICAN JOURNAL OF TRANSPLANTATION, May 2008, Peer-reviewed

  
• Clinical outcome of gemcitabine/S-1 combination therapy for advanced pancreatic cancer

  Junichi Yamauchi; Masashi Kanai; Shigemi Matsumoto; Takafumi Nishimura; Shujiro Yazumi; Kazuhiro Kami; Yoshiya Kawaguchi; Hiroyasu Yasuda; Toshiyuki Kitano; Akiko Misawa; Hiroshi Ishiguro; Kiyotsugu Yoshikawa; Kazuhiro Yanagihara; Masanori Fukushima; Ryuichiro Doi; Tsutomu Chiba

  PANCREAS, Apr. 2008, Peer-reviewed

  
• Intraductal papillary mucinous neoplasms of the pancreas: Clinicopathologic characteristics and long-term follow-up after resection

  Kazuyuki Nagai; Ryuichiro Doi; Atsushi Kida; Kazuhiro Kami; Yoshiya Kawaguchi; Tatsuo Ito; Takaki Sakurai; Shinji Uemoto

  WORLD JOURNAL OF SURGERY, Feb. 2008, Peer-reviewed

  
• Genetic studies on the development of cochlear nucleus neurons using Ptf1a-cre knock-in mice

  Tomoyuki Fujiyama; Mayumi Yamada; Mami Terao; Toshio Terashima; Yuchio Yanagawa; Kunihiko Obata; Yoshiya Kawaguchi; Yo-Ichi Nabeshima; Mikio Hoshino

  NEUROSCIENCE RESEARCH, 2008, Peer-reviewed

  
• A new technique for intraoperative continuous biliary drainage during pancreatoduodenectomy

  Ryuichiro Doi; Kazuhiro Kami; Atsushi Kida; Kazuyuki Nagai; Kohei Ogawa; Yoshiya Kawaguchi; Hiroto Egawa; Shinji Uemoto

  DIGESTIVE SURGERY, 2008, Peer-reviewed

  
• Rbp-j regulates expansion of pancreatic epithelial cells and their differentiation into exocrine cells during mouse development

  Junji Fujikura; Kiminori Hosoda; Yoshiya Kawaguchi; Michio Noguchi; Hiroshi Iwakura; Shinji Odori; Eisaku Mori; Tsutomu Tomita; Masakazu Hirata; Ken Ebihara; Hiroaki Masuzaki; Akihisa Fukuda; Kenichiro Furuyama; Kenji Tanigaki; Daisuke Yabe; Kazuwa Nakao

  DEVELOPMENTAL DYNAMICS, Oct. 2007, Peer-reviewed

  
• Origin of climbing fiber neurons and their developmental dependence on Ptf1a

  Mayumi Yamada; Mami Terao; Toshio Terashima; Tomoyuki Fujiyama; Yoshiya Kawaguchi; Yo-ichi Nabeshima; Mikio Hoshino

  JOURNAL OF NEUROSCIENCE, Oct. 2007, Peer-reviewed

  
• Effect of the XIAP inhibitor embelin on TRAIL-induced apoptosis of pancreatic cancer cells

  Tomohiko Mori; Ryuichiro Doi; Atsushi Kida; Kazuyuki Nagai; Kazuhiro Kami; Daisuke Ito; Eiji Toyoda; Yoshiya Kawaguchi; Shinji Uemoto

  JOURNAL OF SURGICAL RESEARCH, Oct. 2007, Peer-reviewed

  
• Origin of climbing fiber neurons and their developmental dependence on Ptf1a

  Mayumi Yamada; Mami Terao; Toshio Terashima; Tomoyuki Fujiyama; Yoshiya Kawaguchi; Yo-Ichi Nabeshima; Mikio Hoshino

  NEUROSCIENCE RESEARCH, 2007, Peer-reviewed

  
• What the developmental biology in pancreatogenesis brought us: insights in human diseases and possible application to the regenerative therapy for diabetes

  Y. Kawaguchi

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2007, Peer-reviewed

  
• A case of ruptured liver abscess caused by Clostridium perfringens after pancreatoduodenectomy

  Masaharu Tada; Ryuichiro Doi; Kohei Ogawa; Yoshiya Kawaguchi; Hiroto Egawa; Fumihiko Hirai; Shinji Uemoto

  Japanese Journal of Gastroenterological Surgery, 2007, Peer-reviewed

  
• Prognostic implication of para-aortic lymph node metastasis in resectable pancreatic cancer

  Ryuichiro Doi; Kazuhiro Kami; Daisuke Ito; Koji Fujimoto; Yoshiya Kawaguchi; Michihiko Wada; Masafumi Kogire; Ryo Hosotani; Masayuki Imamura; Shinji Uemoto

  WORLD JOURNAL OF SURGERY, Jan. 2007, Peer-reviewed

  
• Ptf1a determines horizontal and amacrine cell fates during mouse retinal development

  Yoshio Fujitani; Shuko Fujitani; Huijun Luo; Feng Qiu; Jared Burlison; Qiaoming Long; Yoshiya Kawaguchi; Helena Edlund; Raymond J. MacDonald; Takahisa Furukawa; Takashi Fujikado; Mark A. Magnuson; Mengqing Xiang; Christopher V. E. Wright

  DEVELOPMENT, Nov. 2006, Peer-reviewed

  
• Forced expression of PDX-1 induces insulin production in intestinal epithelia

  Masayuki Koizumi; Kazuyuki Nagai; Atsushi Kida; Kazuhiro Kami; Daisuke Ito; Koji Fujimoto; Yoshiya Kawaguchi; Ryuichiro Doi

  SURGERY, Aug. 2006, Peer-reviewed

  
• Ectopic pancreas formation in Hes1-knockout mice reveals plasticity of endodermal progenitors of the gut, bile duct, and pancreas

  A Fukuda; Y Kawaguchi; K Furuyama; S Kodama; M Horiguchi; T Kuhara; M Koizumi; DF Boyer; K Fujimoto; R Doi; R Kageyama; CVE Wright; T Chiba

  JOURNAL OF CLINICAL INVESTIGATION, Jun. 2006, Peer-reviewed

  
• Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activation

  T Miyatsuka; H Kaneto; T Shiraiwa; TA Matsuoka; K Yamamoto; K Kato; Y Nakamura; S Akira; K Takeda; Y Kajimoto; Y Yamasaki; EP Sandgren; Y Kawaguchi; CVE Wright; Y Fujitani

  GENES & DEVELOPMENT, Jun. 2006, Peer-reviewed

  
• Expression of the gene for a membrane-bound fatty acid receptor in the pancreas and islet cell tumours in humans: evidence for GPR40 expression in pancreatic beta cells and implications for insulin secretion

  T Tomita; H Masuzuaki; H Iwakura; J Fujikura; M Noguchi; T Tanaka; K Ebihara; J Kawamura; Komoto, I; Y Kawaguchi; K Fujimoto; R Doi; Y Shimada; K Hosoda; M Imamura; K Nakao

  DIABETOLOGIA, May 2006, Peer-reviewed

  
• In vivo antitumor effect of the mTOR inhibitor CCI-779 and gemcitabine in xenograft models of human pancreatic cancer

  D Ito; K Fujimoto; T Mori; K Kami; M Koizumi; E Toyoda; Y Kawaguchi; R Doi

  INTERNATIONAL JOURNAL OF CANCER, May 2006, Peer-reviewed

  
• Loss of the major duodenal papilla results in brown pigment biliary stone formation in pdx1 null mice

  A Fukuda; Y Kawaguchi; K Furuyama; S Kodama; T Kuhara; M Horiguchi; M Koizumi; K Fujimoto; R Doi; CVE Wright; T Chiba

  GASTROENTEROLOGY, Mar. 2006, Peer-reviewed

  
• Mesenchymal epimorphin is important for pancreatic duct morphogenesis

  SS Tulachan; R Doi; Y Hirai; Y Kawaguchi; M Koizumi; M Hembree; E Tei; A Crowley; H Yew; C McFall; K Prasadan; B Preuett; M Imamura; GK Gittes

  DEVELOPMENT GROWTH & DIFFERENTIATION, Feb. 2006, Peer-reviewed

  
• Clinical significance of focal adhesion kinase in resectable pancreatic cancer

  K Furuyama; R Doi; T Mori; E Toyoda; D Ito; K Kami; M Koizumi; A Kida; Y Kawaguchi; K Fujimoto

  WORLD JOURNAL OF SURGERY, Feb. 2006, Peer-reviewed

  
• Surgical treatment of carcinoma of the pancreas

  R. Doi; K. Kami; D. Ito; Y. Kawaguchi; S. Uemoto; S. Yoshida

  Nippon Geka Gakkai zasshi, 2006, Peer-reviewed

  
• Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation

  Y Fujitani; S Fujitani; DF Boyer; M Gannon; Y Kawaguchi; M Ray; M Shiota; RW Stein; MA Magnuson; CVE Wright

  GENES & DEVELOPMENT, Jan. 2006, Peer-reviewed

  
• GPR40 gene expression in human pancreas and insulinoma

  T Tomita; H Masuzaki; M Noguchi; H Iwakura; J Fujikura; T Tanaka; K Ebihara; J Kawamura; Komoto, I; Y Kawaguchi; K Fujimoto; R Doi; Y Shimada; K Hosoda; M Imamura; K Nakao

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Dec. 2005, Peer-reviewed

  
• Downregulation of survivin by siRNA diminishes radioresistance of pancreatic cancer cells

  K Kami; R Doi; M Koizumi; E Toyoda; T Mori; D Ito; Y Kawaguchi; K Fujimoto; M Wada; SI Miyatake; M Imamura

  SURGERY, Aug. 2005, Peer-reviewed

  
• Pancreatic epithelial cells can be converted into insulin-producing cells by GLP-1 in conjunction with virus-mediated gene transfer of pdx-1

  M Koizumi; R Doi; K Fujimoto; D Ito; E Toyoda; T Mori; K Kami; Y Kawaguchi; GK Gittes; M Imamura

  SURGERY, Aug. 2005, Peer-reviewed

  
• Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum

  M Hoshino; S Nakamura; K Mori; T Kawauchi; M Terao; YV Nishimura; A Fukuda; T Fuse; N Matsuo; M Sone; M Watanabe; H Bito; T Terashima; CVE Wright; Y Kawaguchi; K Nakao; YI Nabeshima

  NEURON, Jul. 2005, Peer-reviewed

  
• Regulation of the resistance to TRAIL-induced apoptosis as a new strategy for pancreatic cancer

  T Mori; R Doi; E Toyoda; M Koizumi; D Ito; K Kami; A Kida; T Masui; Y Kawaguchi; K Fujimoto

  SURGERY, Jul. 2005, Peer-reviewed

  
• Hepatic regeneration and enforced PDX-1 expression accelerate transdifferentiation in liver

  M Koizumi; R Doi; E Toyoda; SS Tulachan; K Kami; T Mori; D Ito; Y Kawaguchi; K Fujimoto; GK Gittes; M Imamura

  SURGERY, Aug. 2004, Peer-reviewed

  
• Chronic exposure of transforming growth factor, beta 1 confers a more aggressive tumor phenotype through downregulation of p21 (WAF1/CIP1) in conditionally immortalized pancreatic epithelial cells

  D Ito; K Fujimoto; R Doi; M Koizumi; E Toyoda; T Mori; K Kami; Y Kawaguchi; R Whitehead; M Imamura

  SURGERY, Aug. 2004, Peer-reviewed

  
• N-cadherin expression and epithelial-mesenchymal transition in pancreatic carcinoma

  S Nakajima; R Doi; E Toyoda; S Tsuji; M Wada; M Koizumi; SS Tulachan; D Ito; K Kami; T Mori; Y Kawaguchi; K Fujimoto; R Hosotani; M Imamura

  CLINICAL CANCER RESEARCH, Jun. 2004, Peer-reviewed

  
• Erratum: Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse (Cancer Cell (4) (437-450))

  S.R. Hingorani; E.F. Petricoin III; A. Maitra; V. Rajapakse; C. King; M.A. Jacobetz; S. Ross; T.P. Conrads; T.D. Veenstra; B.A. Hitt; Y. Kawaguchi; D. Johann; L.A. Liotta; H.C. Crawford; M.E. Putt; T. Jacks; C.V.E. Wright; R.H. Hruban; A.M. Lowy; D.A. Tuveson

  Cancer Cell, 2004, Peer-reviewed

  
• Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

  Hingorani, SR; EF Petricoin; A Maitra; Rajapakse, V; C King; MA Jacobetz; S Ross; TP Conrads; TD Veenstra; BA Hitt; Y Kawaguchi; D Johann; LA Liotta; HC Crawford; ME Putt; T Jacks; CVE Wright; RH Hruban; AM Lowy; DA Tuveson

  CANCER CELL, Dec. 2003, Peer-reviewed

  
• Increased PDX-1 expression is associated with outcome in patients with pancreatic cancer

  M Koizumi; R Doi; E Toyoda; T Masui; SS Tulachan; Y Kawaguchi; K Fujimoto; GK Gittes; M Imamura

  SURGERY, Aug. 2003, Peer-reviewed

  
• All-trans retinoic acid induces differentiation of ducts and endocrine cells by mesenchymal/epithelial interactions in embryonic pancreas

  SS Tulachan; R Doi; Y Kawaguchi; S Tsuji; S Nakajima; T Masui; M Koizumi; E Toyoda; T Mori; D Ito; K Kami; K Fujimoto; M Imamura

  DIABETES, Jan. 2003, Peer-reviewed

  
• The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors

  Y Kawaguchi; B Cooper; M Gannon; M Ray; RJ MacDonald; CVE Wright

  NATURE GENETICS, Sep. 2002, Peer-reviewed

  
• Differential expression of human spasmolytic polypeptide (trefoil factor family-2) in pancreatic carcinomas, ampullary carcinomas, and mucin-producing tumors of the pancreas

  G Ohshio; H Suwa; Y Kawaguchi; M Imamura; Y Yamaoka; H Yamabe; M Matsumoto; H Yoshioka; Y Hashimoto; H Takeda

  DIGESTIVE DISEASES AND SCIENCES, Apr. 2000, Peer-reviewed

  
• A CAG/CTG expansion in the normal population

  M Nakamoto; H Takebayashi; Y Kawaguchi; S Narumiya; M Taniwaki; Y Nakamura; Y Ishikawa; Akiguchi, I; J Kimura; A Kakizuka

  NATURE GENETICS, Dec. 1997, Peer-reviewed

  
• Expression of Fas-estrogen receptor fusion protein induces cell death in pancreatic cancer cell lines

  Y Kawaguchi; H Takebayashi; A Kakizuka; S Arii; M Kato; M Imamura

  CANCER LETTERS, Jun. 1997, Peer-reviewed

  
• Evaluation of cholecystokinin, gastrin, CCK-A receptor, and CCK-B/gastrin receptor gene expressions in gastric cancer

  N Okada; A Kubota; T Imamura; H Suwa; Y Kawaguchi; G Ohshio; Y Seino; M Imamura

  CANCER LETTERS, Sep. 1996, Peer-reviewed

  
• MOLECULAR-FEATURES OF THE CAG REPEATS AND CLINICAL MANIFESTATION OF MACHADO-JOSEPH DISEASE

  H MARUYAMA; S NAKAMURA; Z MATSUYAMA; T SAKAI; M DOYU; G SOBUE; M SETO; M TSUJIHATA; T OHI; T NISHIO; N SUNOHARA; R TAKAHASHI; M HAYASHI; NISHINO, I; T OHTAKE; T ODA; M NISHIMURA; T SAIDA; H MATSUMOTO; M BABA; Y KAWAGUCHI; A KAKIZUKA; H KAWAKAMI

  HUMAN MOLECULAR GENETICS, May 1995, Peer-reviewed

  
• UNIQUE FEATURES OF THE CAG REPEATS IN MACHADO-JOSEPH DISEASE

  H KAWAKAMI; H MARUYAMA; S NAKAMURA; Y KAWAGUCHI; A KAKIZUKA; M DOYU; G SOBUE

  NATURE GENETICS, Apr. 1995, Peer-reviewed

  
• CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1

  Y. Kawaguchi; T. Okamoto; M. Taniwaki; M. Aizawa; M. Inoue; S. Katayama; H. Kawakami; S. Nakamura; M. Nishimura; I. Akiguchi; J. Kimura; S. Narumiya; A. Kakizuka

  Nature Genetics, Nov. 1994, Peer-reviewed

  
• Effect of the intravenous administration of sepinostat mesilate on cerulein induced acute pancreatitis in rats

  Z.-H. Wang; T. Manabe; G. Ohshio; T. Kyogoku; N. Okada; F. Yotsumoto; T. Imamura; K.-I. Yamaki; Y. Kawaguchi; M. Imamura

  Surgical Research Communications, 1994, Peer-reviewed

  
• Sequence analysis of cloned cDNA for rat substance P precursor: Existence of a third substance P precursor

  Y. Kawaguchi; M. Hoshimaru; H. Nawa; S. Nakanishi

  Biochemical and Biophysical Research Communications, 1986, Peer-reviewed

  

Misc.

• Resolution of Preoperative Portal Vein Thrombosis After Administration of Antithrombin III in Living Donor Liver Transplantation: Case Report

  H. Imai; H. Egawa; M. Kajiwara; A. Nakajima; Y. Ogura; E. Hatano; M. Ueda; Y. Kawaguchi; T. Kaido; Y. Takada; S. Uemoto

  TRANSPLANTATION PROCEEDINGS, Nov. 2009, Peer-reviewed

  
• Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis

  Jennifer P. Morton; Michelle E. Mongeau; David S. Klimstra; John P. Morris; Yie Chia Lee; Yoshiya Kawaguchi; Christopher V. E. Wright; Matthias Hebrok; Brian C. Lewis

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Mar. 2007, Peer-reviewed

  

Presentations

• Cre/loxP を用いた細胞系譜解析法による臓器発生・成体臓器維持機構の解明

  第52回日本組織細胞化学総会学術集会, Sep. 2011, 日本組織細胞化学会

  
• 成体肝・膵・腸の維持機構

  第29回日本ヒト細胞学会学術集会, Aug. 2011, 日本ヒト細胞学会

  
• 肝臓・膵外分泌・腸管におけるSOX9陽性前駆領域からの持続的細胞供給

  第97回日本消化器病学会総会, May 2011, 日本消化器病学会

  
• Continuous cell supply from Sox9-expressing progenitors in adult liver, exocrine pancreas and intestine

  3rd Symposium of the IMSUT and RCAST Global COE, May 2011, 東京大学

  
• 臓器形成・機能と幹細胞システム

  JDDW2010, Oct. 2010, JDDW(肝臓学会・消化器病学会)

  
• Genetic lineage tracing, a powerful tool to investigate the embryonic organogenesis and adult organ maintenance of the pancreas

  熊本大学グローバルCOEリエゾンラボ研究会, Oct. 2010, 熊本大学

  
• Mechanism of pancreatic cell maintenance and its implication in carcinogenesis

  Tokyo Symposium on pancreatic cancer, Aug. 2009, 日本膵臓学会

  
• 膵発生に病気の発症メカニズムをもとめて～膵島移植もやってます！～

  第2回先進治療学セミナー, Jun. 2008, 順天堂大学

  
• Notchシグナルと異所性膵臓発生

  第51回日本糖尿病学会年次学術総会, May 2008, 日本糖尿病学会

  

Awards

• 04 Feb. 2005

  Cytoprotection 研究会, 奨励賞

External funds: others

• 成体肝・膵特異的幹細胞機能維持機構の解明とその破綻による疾患モデルの開発

  最先端次世代研究開発支援プログラム

  From Feb. 2011

  代表

Education

Teaching subject(s)

• From Apr. 2011, To Mar. 2012

  Clinical Overview of Surgery II

  Fall, 医学部（人間健康科学科）
• From Apr. 2012, To Mar. 2013

  Clinical Overview of Surgery II

  Fall, 医学部（人間健康科学科）
• From Apr. 2013, To Mar. 2014

  Clinical Overview of Surgery II

  Fall, 医学部（人間健康科学科）
• From Apr. 2014, To Mar. 2015

  Clinical Overview of Surgery II

  Fall, 医学部（人間健康科学科）
• From Apr. 2015, To Mar. 2016

  Clinical Overview of Surgery II

  Fall, 医学部（人間健康科学科）
• From Apr. 2010, To Mar. 2011

  Gastroenterology and mark Hepatology

  Spring, 医学部（医学科）
• From Apr. 2011, To Mar. 2012

  Gastroenterology and mark Hepatology

  Spring, 医学部（医学科）
• From Apr. 2012, To Mar. 2013

  Gastroenterology and mark Hepatology

  Spring, 医学部（医学科）
• From Apr. 2013, To Mar. 2014

  Gastroenterology and mark Hepatology

  Spring, 医学部（医学科）
• From Apr. 2014, To Mar. 2015

  Gastroenterology and mark Hepatology

  Spring, 医学部（医学科）
• From Apr. 2015, To Mar. 2016

  Gastroenterology and mark Hepatology

  Spring, 医学部（医学科）
• From Apr. 2016, To Mar. 2017

  Clinical Overview of Surgery II

  Fall, 医学部（人間健康科学科）
• From Apr. 2017, To Mar. 2018

  Clinical Overview of Surgery II

  Fall, 医学部（人間健康科学科）

Participation in PhD Defense

• Rat tracheal cartilage regeneration using mesenchymal stem cells derived from human iPS cells

  MIZUNO KEISUKE, Graduate School of Medicine, Sub-chief Examiner

  24 Mar. 2025
• Intestinal Morphology and Glucose Transporter Gene Expression under a Chronic Intake of High Sucrose

  YAMAMOTO KANA, Graduate School of Medicine, Chief Examiner

  24 Sep. 2024
• Prediction for oxaliplatin-induced liver injury using patient-derived liver organoids

  TATSUMI KUMIKO, Graduate School of Medicine, Sub-chief Examiner

  23 Jul. 2024
• Pancreatic RECK inactivation promotes cancer formation, epithelial-mesenchymal transition, and metastasis

  MASUDA TOMONORI, Graduate School of Medicine, Sub-chief Examiner

  25 Mar. 2024
• Elucidation of the liver pathophysiology of COVID-19 patients using liver-on-a-chips

  DEGUCHI SAYAKA, Graduate School of Medicine, Chief Examiner

  25 Mar. 2024
• Ferroptosis-related Gene Glutathione Peroxidase 4 Promotes Reprogramming of Glucose Metabolism via Akt-mTOR Axis in Intrahepatic Cholangiocarcinoma

  HORI YUTARO, Graduate School of Medicine, Chief Examiner

  25 Mar. 2024
• Purification of human iPSC-derived cells at large scale using microRNA switch and magnetic-activated cell sorting

  TSUJISAKA YUTA, Graduate School of Medicine, Chief Examiner

  25 Mar. 2024
• ELF3 suppresses gallbladder cancer development through downregulation of the EREG/EGFR/mTOR complex 1 signalling pathway

  NAKAMURA TAKEHARU, Graduate School of Medicine, Chief Examiner

  25 Mar. 2024
• Loss of Arid1a and Pten in Pancreatic Ductal Cells Induces Intraductal Tubulopapillary Neoplasm via the YAP/TAZ Pathway

  FUKUNAGA YUICHI, Graduate School of Medicine, Chief Examiner

  23 May 2023
• Comparison of minimally invasive surgery with open surgery for remnant gastric cancer: A Multi-institutional Cohort Study

  AOYAMA RYUHEI, Graduate School of Medicine, Sub-chief Examiner

  23 May 2023
• Efficacious Combination Drug Treatment for Colorectal Cancer that Overcomes Resistance to KRAS G12C Inhibitors

  MATSUBARA HIROYUKI, Graduate School of Medicine, Sub-chief Examiner

  23 May 2023
• Noninvasive quantitative evaluation of viable islet grafts using 111In-exendin-4 SPECT/CT

  AINUR BOTAGAROVA, Graduate School of Medicine, Chief Examiner

  24 Nov. 2023
• Impact of Prevascularization on Immunological Environment and Early Engraftment in Subcutaneous Islet Transplantation

  INOGUCHI KENTA, Graduate School of Medicine, Chief Examiner

  25 Mar. 2024
• Elucidation of HHEX in pancreatic endoderm differentiation using a human iPSC differentiation model

  ITO RYO, Graduate School of Medicine, Chief Examiner

  23 Jan. 2024
• Preservation effect of imeglimin on pancreatic β-cell mass: Noninvasive evaluation using 111In-exendin-4 SPECT/CT imaging and the perspective of mitochondrial involvements

  MUHAMMAD FAUZI, Graduate School of Medicine, Chief Examiner

  23 Mar. 2023
• Context-Dependent Roles of Hes1 in the Adult Pancreas and Pancreatic Tumor Formation

  MARUI SAIKO, Graduate School of Medicine, Chief Examiner

  23 Mar. 2023
• Impact of very early introduction of everolimus on liver regeneration after partial liver transplantation in rats

  HIRATA MASAAKI, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2023
• Anti-integrin αvβ6 antibody as a diagnostic marker for pediatric patients with ulcerative colitis

  MURAMOTO YUYA, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2023
• Liver ductal organoids reconstruct intrahepatic biliary trees in decellularized liver grafts

  TOMOFUJI KATSUHIRO, Graduate School of Medicine, Chief Examiner

  26 Sep. 2022
• Essential role of Notch/Hes1 signaling in postnatal pancreatic　exocrine development

  KURIYAMA KATSUTOSHI, Graduate School of Medicine, Chief Examiner

  23 Mar. 2023
• Post-transplant lymphoproliferative disorders after liver transplantation: A retrospective cohort study including 1,954 transplants

  TAJIMA TETSUYA, Graduate School of Medicine, Sub-chief Examiner

  26 Jul. 2021
• Brg1 is required to maintain colorectal cancer stem cells

  YOSHIKAWA TAKAAKI, Graduate School of Medicine, Chief Examiner

  23 Mar. 2022
• Prevascularization-free Primary Subcutaneous Transplantation of Xenogeneic Islets Co-encapsulated with Hepatocyte Growth Factor

  YANG, SIN-YU, Graduate School of Medicine, Chief Examiner

  24 May 2021
• MYCL promotes iPSC-like colony formation via MYC Box 0 and 2 domains

  AKIFUJI CHIAKI, Graduate School of Medicine, Chief Examiner

  23 Mar. 2022
• Increased expression of programmed cell death ligand 1 and galectin 9 in transplant recipients who achieved tolerance after immunosuppression withdrawal

  NGUYEN HAI NAM, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2022
• Capturing human trophoblast development with naive pluripotent stem cells in vitro

  IO SHINGO, Graduate School of Medicine, Chief Examiner

  24 Nov. 2021
• Core-shell hydrogel microfiber-expanded pluripotent stem cell-derived lung progenitors applicable to lung reconstruction in vivo

  IKEO SATOSHI, Graduate School of Medicine, Sub-chief Examiner

  24 Jan. 2022
• DNA methyltransferase 3B plays a protective role against hepatocarcinogenesis caused by chronic inflammation via maintaining mitochondrial homeostasis

  IGUCHI ERIKO, Graduate School of Medicine, Sub-chief Examiner

  26 Jul. 2021
• Bolus Administration of Polyamines Boosts Effects on Hepatic Ischemia-Reperfusion Injury and Regeneration in Rats

  DOI JUNSHI, Graduate School of Medicine, Chief Examiner

  24 Nov. 2021
• Carbonic anhydrase 8 (CAR8) negatively regulates GLP-1 secretion from enteroendocrine cells in response to long-chain fatty acids

  FUJIWARA YUTA, Graduate School of Medicine, Sub-chief Examiner

  26 Jul. 2021
• Visualization of stem cell activity in pancreatic cancer expansion by direct lineage tracing with live imaging

  MARUNO TAKAHISA, Graduate School of Medicine, Sub-chief Examiner

  26 Jul. 2021

Administration

Faculty management (title, position)

• From 01 Apr. 2022, To 31 Mar. 2025

  医学部附属病院 先端医療研究開発機構 先制医療・生活習慣病研究センター評価委員会
• From 01 Apr. 2020, To 31 Mar. 2026

  共通機器管理運営委員会1号委員
• From 01 Jun. 2011

  医学・病院地区FACS委員会
• From 01 Apr. 2022, To 31 Mar. 2026

  医生物学研究所医の倫理委員会
• From 01 Apr. 2017, To 31 Mar. 2022

  ウイルス・再生医科学研究所医の倫理委員会
• From 01 Apr. 2016, To 31 Mar. 2017

  京都大学再生医科学研究所、物質ー細胞統合システム拠点およびiPS細胞研究所合同医の倫理委員会
• From 01 Nov. 2018

  医学研究科カリキュラム検討WG
• From 01 Apr. 2020, To 31 Mar. 2026

  財務委員会2号委員
• From 23 Jan. 2020, To 31 Mar. 2027

  動物実験施設運営委員会