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Koyama, Mei
Center for iPS Cell Research and Application (CiRA) Program-Specific Research Center Assistant Professor
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Last Updated :2026/08/22
Basic Information
Email Address
Email Address
koyama.mei.2m
kyoto-u.ac.jp
Academic Degree
- 23 Mar. 2016Ph.D. (Biostudies) (Kyoto University)
- 23 Mar. 2009Master (Biostudies) (Kyoto University)
Academic Resume (Graduate Schools)
- Kyoto University, Graduate School of Biostudies, Ph.D. Program, Withdrawal from the Research Guidance Certification Program
- Kyoto University, Graduate School of Biostudies, Master's Program, Completed
Academic Resume (Undergraduate School/Majors)
Research History
- From Jun. 2025, To PresentKyoto University, CiRA, Department of Life Science Frontiers, Program-specific Assistant Professor
- From Apr. 2023, To May 2025Kyoto University, CiRA, Department of Life Science Life Science Frontiers, Program-specific Researcher
- From Apr. 2020, To Mar. 2023Kyoto University, CiRA, Department of Life Science Life Science Frontiers, JSPS Fellow (RPD)
- From Apr. 2019, To Mar. 2020Kyoto University, CiRA, Department of Life Science Life Science Frontiers, Program-specific Researcher
- From Oct. 2012, To Mar. 2019Kyoto University, Graduate School of Biostudies, Researcher
- From Apr. 2009, To Sep. 2012Kyoto University, Graduate School of Biostudies, JSPS Fellow (DC1)
Language of Instruction
ID,URL
J-Global ID
Researcher number
80868026
researchmap URL
list
Last Updated :2026/08/22
Research
Research Topics, Overview of the research
Research Topics
Elucidating the Mechanisms of Aging at the Cellular, Organ, and Organismal LevelsOverview of the research
Using the intestinal epithelium as a model system, my goal is to elucidate the mechanisms of stem cell aging and their impact on intestinal diseases and organismal aging.
Research Interests
Research Areas
Papers
- Characterizing primary and secondary senescence in vivo.Yuko Sogabe; Hirofumi Shibata; Mio Kabata; Akito Tanaka; Kanae Mitsunaga; Kazunori Sunadome; May Nakajima-Koyama; Michitada Hirano; Eisuke Nishida; Knut Woltjen; Hiroshi Seno; Yasuhiro Yamada; Takuya YamamotoNature aging, 11 Jul. 2025, Peer-reviewed
- The balance between IFN-γ and ERK/MAPK signaling activities ensures lifelong maintenance of intestinal stem cellsMay Nakajima-Koyama; Mio Kabata; Joonseong Lee; Yuko Sogabe; Satoko Sakurai; Akira Hirota; Mizuki Kimura; Tomonori Nakamura; Yusuke Imoto; Kohei Kometani; Yoko Hamazaki; Yasuaki Hiraoka; Mitinori Saitou; Eisuke Nishida; Takuya YamamotoCell Reports, Feb. 2025, Peer-reviewed, Lead author, Corresponding author
- Construction of multilayered small intestine-like tissue by reproducing interstitial flow.Sayaka Deguchi; Kaori Kosugi; Naoki Takeishi; Yukio Watanabe; Shiho Morimoto; Ryosuke Negoro; Fuki Yokoi; Hiroki Futatsusako; May Nakajima-Koyama; Mio Iwasaki; Takuya Yamamoto; Yoshiya Kawaguchi; Yu-Suke Torisawa; Kazuo TakayamaCell stem cell, 03 Jul. 2024, Peer-reviewed
- Selective induction of human renal interstitial progenitor-like cell lineages from iPSCs reveals development of mesangial and EPO-producing cellsHiraku Tsujimoto; Azusa Hoshina; Shin-Ichi Mae; Toshikazu Araoka; Wang Changting; Yoshihiro Ijiri; May Nakajima-Koyama; Satoko Sakurai; Kazusa Okita; Ken Mizuta; Akira Niwa; Megumu K. Saito; Mitinori Saitou; Takuya Yamamoto; Cecilia Graneli; Kevin J. Woollard; Kenji OsafuneCell Reports, Jan. 2024, Peer-reviewed
- Hypoblast from human pluripotent stem cells regulates epiblast development.Takumi Okubo; Nicolas Rivron; Mio Kabata; Hideki Masaki; Keiko Kishimoto; Katsunori Semi; May Nakajima-Koyama; Haruko Kunitomi; Belinda Kaswandy; Hideyuki Sato; Hiromitsu Nakauchi; Knut Woltjen; Mitinori Saitou; Erika Sasaki; Takuya Yamamoto; Yasuhiro TakashimaNature, 05 Dec. 2023, Peer-reviewed
- Single-cell RNA-seq reveals heterogeneity in hiPSC-derived muscle progenitors and E2F family as a key regulator of proliferationNalbandian M; Zhao M; Kato H; Jonouchi T; Nakajima-Koyama M; Yamamoto T; Sakurai HLife science alliance, Apr. 2022, Peer-reviewed
- The nucleosome remodeling and deacetylase complex protein CHD4 regulates neural differentiation of mouse embryonic stem cells by down-regulating p53Akira Hirota; May Nakajima-Koyama; Yuhei Ashida; Eisuke NishidaJournal of Biological Chemistry, Jan. 2019, Peer-reviewed, Corresponding author
- Antagonistic Interactions between Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase and Retinoic Acid Receptor Signaling in Colorectal Cancer CellsMasamichi Imajo; Kunio Kondoh; Takuya Yamamoto; Kei Nakayama; May Nakajima-Koyama; Eisuke NishidaMolecular and Cellular Biology, Aug. 2017, Peer-reviewed
- Identification and characterization of secreted factors that are upregulated during somatic cell reprogrammingYoshimi Bansho; Joonseong Lee; Eisuke Nishida; May Nakajima‐KoyamaFEBS Letters, Jun. 2017, Peer-reviewed, Last author, Corresponding author
- Activin A in combination with ERK1/2 MAPK pathway inhibition sustains propagation of mouse embryonic stem cellsYuhei Ashida; May Nakajima-Koyama; Akira Hirota; Takuya Yamamoto; Eisuke NishidaGenes to Cells, Feb. 2017, Peer-reviewed
- Transient Expression of WNT2 Promotes Somatic Cell Reprogramming by Inducing β-Catenin Nuclear AccumulationMizuki Kimura; May Nakajima-Koyama; Joonseong Lee; Eisuke NishidaStem Cell Reports, Jun. 2016, Peer-reviewed, Corresponding author
- Induction of Pluripotency in Astrocytes through a Neural Stem Cell-like StateMay Nakajima-Koyama; Joonseong Lee; Sho Ohta; Takuya Yamamoto; Eisuke NishidaJournal of Biological Chemistry, Dec. 2015, Peer-reviewed, Lead author
- Secreted Ephrin Receptor A7 Promotes Somatic Cell Reprogramming by Inducing ERK Activity ReductionJoonseong Lee; May Nakajima-Koyama; Masamitsu Sone; Makito Koga; Miki Ebisuya; Takuya Yamamoto; Eisuke NishidaStem Cell Reports, Oct. 2015, Peer-reviewed
- Ripples from neighbouring transcriptionMiki Ebisuya; Takuya Yamamoto; May Nakajima; Eisuke NishidaNature Cell Biology, Sep. 2008, Peer-reviewed
Presentations
- A Comparative Analysis of the Small and Large Intestines Decodes the Temporal Programs of Intestinal Stem Cells小山明; 山本拓也第23回幹細胞シンポジウム, 22 May 2026
- 腸管上皮幹細胞の領域特異性と老化小山 明第16回幹細胞若手の会（つくしの会）, 22 May 2026
- 腸の細胞社会から学ぶ：「生きる」とは何か？小山明第8回CiRA奨励賞表彰式・発表会, 20 Feb. 2026
- Adaptive System for Lifelong Maintenance of Intestinal Stem Cells小山(中島)明; 西田栄介; 山本拓也第48回日本分子生物学会 ライフステージにおける組織恒常性変化, 04 Dec. 2025
- Decoding Intestinal Stem Cell Aging: From Visualization to RegulationMay Nakajima-Koyama52nd ASHBi Colloquium, 22 Jul. 2025
- Decoding the Time Axis of Life through Omics Technologies ーInsights into Stem Cell Aging at the Molecular Levelー小山(中島)明京都大学大学院医学研究科教育コース「再生医療・臓器再建医学コース」, 06 Jun. 2025, Invited
- The balance between IFN-γ and ERK/MAPK signaling activities safeguards the intestinal stem cell population during aging.小山(中島)明、西田栄介、山本拓也第22回幹細胞シンポジウム, 23 May 2025
- The Signaling Buffering System that Ensures Lifelong Maintenance of Intestinal Stem CellsMay Nakajima-Koyama; Eisuke Nishida; Takuya YamamotoRIKEN BDR Symposium 2025 Towards Redesigning Lifecycles, 04 Mar. 2025
- 加齢に対する小腸上皮の適応機構小山(中島)明; 西田 栄介; 山本 拓也第46回日本分子生物学会年会, 06 Dec. 2023
- iPS細胞とリプログラミング技術を用いた臓器老化・若返り研究の基盤構築小山(中島)明iPSアカデミアジャパン研究助成 2021贈呈式及び研究発表会, 02 Feb. 2022
- Unraveling the aging process of intestinal epithelium using single cell RNA-seq and organoid technologiesMay Nakajima-Koyama京都大学大学院医学研究科教育コース「再生医療・臓器再建医学コース」, 08 Jan. 2021, Invited
- Molecular Hallmarks of Intestinal Stem Cell AgingMay Nakajima-KoyamaASHBi Colloquium, 28 Jul. 2020
- e stem cell niche小山(中島)明第8回幹細胞若手の会（つくしの会）, May 2019
- アストロサイトは神経幹細胞様状態を経てiPS細胞へとリプログラミングされる小山(中島)明; 西田栄介第7回シグナルネットワーク研究会, Jun. 2015
- Sox1, a neural stem cell specific transcription factor, is an intermediate stage marker during the reprogramming of astrocytes into iPS cellsMay Nakajima-Koyama京都大学大学院生命科学研究科 第11回国際学生セミナー, Mar. 2013
Awards
- 20 Feb. 2026京都大学iPS細胞研究所, 第8回CiRA奨励賞小山明
- 06 Mar. 2012The 11th International Student Seminar Short-Talk 優秀賞(京都大学生命科学研究科)
Media Coverage
- 京大、小腸上皮幹細胞の仕組み解明 加齢変化に適応日刊工業新聞, 14 Feb. 2025, Paper
- 小腸の細胞、加齢に適応 情報伝達の働き変化共同通信, 14 Feb. 2025, Paper
- 小腸細胞、抗老化の機能 加齢で情報伝達変化日本経済新聞, 14 Feb. 2025, Paper
External funds: Kakenhi
- 小腸上皮幹細胞老化の組織内伝搬機構の解明Grant-in-Aid for Early-Career ScientistsBasic Section 49030:Experimental pathology-relatedKyoto University小山 明; 中島明From 01 Apr. 2024, To 31 Mar. 2027, Granted腸;幹細胞;老化;scRNA-seq解析;空間トランスクリプトーム解析;間葉系細胞;免疫細胞;小腸;単一細胞トランスクリプトーム解析
- Elucidation of Age-Related Changes in Enteroendocrine Cell Subtype Composition and Their Regulatory MechanismsGrant-in-Aid for Early-Career ScientistsBasic Section 48040:Medical biochemistry-relatedKyoto UniversityMay Nakajima-KoyamaFrom 01 Apr. 2020, To 31 Mar. 2023, Project Closed幹細胞;小腸;加齢;老化;オルガノイド;腸内分泌;トランスクリプトーム解析;シグナル伝達;腸上皮;腸内分泌細胞;シングルセルRNA-seq解析;腸オルガノイド;エイジング;iPS細胞;腸管ホルモン;代謝;single cell RNA-seq;内分泌細胞;RNA-seq
