Basic Information

Affiliated programs (koza)

• Graduate School of Medicine, 医学専攻 感染防御生物学, 特定助教
• Graduate School of Medicine, 医科学専攻 感染防御生物学, 特定助教

Faculty

• 医学部

Professional Memberships

• From Jul. 2019, To Present

  日本分子生物学会
• From Jul. 2012, To Present

  日本免疫学会
• From Oct. 2004, To Present

  日本腎臓学会
• From May 2004, To Present

  日本内科学会

Academic Degree

• 博士（医学）(大阪大学)

Research History

• From Jan. 2024, To Present

  京都大学大学院医学研究科, 医化学分野, 准教授
• From Apr. 2019, To Dec. 2023

  京都大学大学院医学研究科, 医化学分野, 助教
• From Jul. 2017, To Mar. 2019

  京都大学ウイルス・再生医科学研究所, 感染防御分野, 助教
• From May 2016, To Jun. 2017

  京都大学ウイルス・再生医科学研究所, 感染防御分野, 特定助教
• From Apr. 2014, To Apr. 2016

  ニューヨーク大学スカボール研究所, Dan Littman研究室, HFSPフェロー
• From Jun. 2013, To Mar. 2014

  大阪大学大学院医学系研究科, 腎臓内科, 研究員
• From Apr. 2010, To May 2013

  大阪大学免疫学フロンティア研究センター, 博士課程
• From Apr. 2009, To Mar. 2010

  大阪大学医学部附属病院, 老年・腎臓内科, 非常勤医師
• From Apr. 2006, To Mar. 2009

  大阪府立急性期・総合医療センター, 腎臓・高血圧内科, レジデント
• From May 2004, To Mar. 2006

  大阪府立急性期・総合医療センター, 臨床研修医

Language of Instruction

• English

ID,URL

• J-Global ID

  201601015692200110

researchmap URL

• https://researchmap.jp/7000015956

Research

Research Interests

• 癌免疫
• 慢性炎症
• 造血幹細胞機能制御
• T細胞活性化制御
• RNA分解

Research Areas

• Life sciences, Molecular biology
• Life sciences, Immunology

Papers

• Regnase-1 in cDC1 controls T cell priming and shapes the dynamics of experimental autoimmune encephalomyelitis.

  Xingyu Rong; Hai Wang; Shintaro Muraoka; Takuya Uehata; Masanori Yoshinaga; Tsuneyasu Kaisho; Osamu Takeuchi

  Frontiers in immunology, 2025

  
• A feedback amplifier circuit with Notch and E2A orchestrates T-cell fate and suppresses the innate lymphoid cell lineages during thymic ontogeny.

  Kazuko Miyazaki; Kenta Horie; Hitomi Watanabe; Reiko Hidaka; Rinako Hayashi; Norihito Hayatsu; Kentaro Fujiwara; Rei Kuwata; Takuya Uehata; Yotaro Ochi; Makoto Takenaka; Risa Karakida Kawaguchi; Koichi Ikuta; Osamu Takeuchi; Seishi Ogawa; Katsuto Hozumi; Georg A Holländer; Gen Kondoh; Taishin Akiyama; Masaki Miyazaki

  Genes & development, 04 Feb. 2025

  
• ループス腎炎モデルマウスに対するCD28スーパーアゴニストの治療効果の検証

  高畠 義嗣; 木村 友則; 宮里 研郎; 高橋 篤史; 植畑 拓也; 貝森 淳哉; 川田 典孝; 今井 圓裕; Hunig Thomas; 李 小康; 楽木 宏実; 猪阪 善隆

  日本腎臓学会誌, May 2010

  
• Regulation of lymphoid-myeloid lineage bias through Regnase-1/3-mediated control of Nfkbiz.

  Takuya Uehata; Shinnosuke Yamada; Daisuke Ori; Alexis Vandenbon; Amir Giladi; Adam Jelinski; Yasuhiro Murakawa; Hitomi Watanabe; Kazuhiro Takeuchi; Kazunori Toratani; Takashi Mino; Hisanori Kiryu; Daron M Standley; Tohru Tsujimura; Tomokatsu Ikawa; Gen Kondoh; Markus Landthaler; Hiroshi Kawamoto; Hans-Reimer Rodewald; Ido Amit; Ryo Yamamoto; Masaki Miyazaki; Osamu Takeuchi

  Blood, 03 Nov. 2023

  
• Regnase-1 Prevents Pulmonary Arterial Hypertension Through mRNA Degradation of Interleukin-6 and Platelet-Derived Growth Factor in Alveolar Macrophages.

  Ai Yaku; Tadakatsu Inagaki; Ryotaro Asano; Makoto Okazawa; Hiroyoshi Mori; Ayuko Sato; Fabian Hia; Takeshi Masaki; Yusuke Manabe; Tomohiko Ishibashi; Alexis Vandenbon; Yoshinari Nakatsuka; Kotaro Akaki; Masanori Yoshinaga; Takuya Uehata; Takashi Mino; Satoshi Morita; Hatsue Ishibashi-Ueda; Akio Morinobu; Tohru Tsujimura; Takeshi Ogo; Yoshikazu Nakaoka; Osamu Takeuchi

  Circulation, 27 Sep. 2022

  
• Androgens Alleviate Allergic Airway Inflammation by Suppressing Cytokine Production in Th2 Cells.

  Aki Ejima; Shinya Abe; Akihiro Shimba; Susumu Sato; Takuya Uehata; Shizue Tani-Ichi; Satoru Munakata; Guangwei Cui; Osamu Takeuchi; Toyohiro Hirai; Shigeaki Kato; Koichi Ikuta

  Journal of immunology (Baltimore, Md. : 1950), 15 Sep. 2022

  
• Enhancement of Regnase-1 expression with stem loop-targeting antisense oligonucleotides alleviates inflammatory diseases.

  Ka Man Tse; Alexis Vandenbon; Xiaotong Cui; Takashi Mino; Takuya Uehata; Keiko Yasuda; Ayuko Sato; Tohru Tsujimura; Fabian Hia; Masanori Yoshinaga; Makoto Kinoshita; Tatsusada Okuno; Osamu Takeuchi

  Science translational medicine, 11 May 2022

  
• Cyclin J-CDK complexes limit innate immune responses by reducing proinflammatory changes in macrophage metabolism.

  Yee Kien Chong; Sarang Tartey; Yuki Yoshikawa; Koshi Imami; Songling Li; Masanori Yoshinaga; Ai Hirabayashi; Guohao Liu; Alexis Vandenbon; Fabian Hia; Takuya Uehata; Takashi Mino; Yutaka Suzuki; Takeshi Noda; Dominique Ferrandon; Daron M Standley; Yasushi Ishihama; Osamu Takeuchi

  Science signaling, 12 Apr. 2022

  
• Post-transcriptional regulation of immunological responses by Regnase-1-related RNases.

  Takuya Uehata; Osamu Takeuchi

  International immunology, 25 Nov. 2021

  Access this paper :

  
• PIN and CCCH Zn-finger domains coordinate RNA targeting in ZC3H12 family endoribonucleases.

  Ankur Garg; Yvette Roske; Shinnosuke Yamada; Takuya Uehata; Osamu Takeuchi; Udo Heinemann

  Nucleic acids research, 21 May 2021

  
• Profibrotic function of pulmonary group 2 innate lymphoid cells is controlled by regnase-1.

  Yoshinari Nakatsuka; Ai Yaku; Tomohiro Handa; Alexis Vandenbon; Yuki Hikichi; Yasutaka Motomura; Ayuko Sato; Masanori Yoshinaga; Kiminobu Tanizawa; Kizuku Watanabe; Toyohiro Hirai; Kazuo Chin; Yutaka Suzuki; Takuya Uehata; Takashi Mino; Tohru Tsujimura; Kazuyo Moro; Osamu Takeuchi

  The European respiratory journal, Mar. 2021

  
• The transcription factor E2A activates multiple enhancers that drive Rag expression in developing T and B cells.

  Kazuko Miyazaki; Hitomi Watanabe; Genki Yoshikawa; Kenian Chen; Reiko Hidaka; Yuki Aitani; Kai Osawa; Rie Takeda; Yotaro Ochi; Shizue Tani-Ichi; Takuya Uehata; Osamu Takeuchi; Koichi Ikuta; Seishi Ogawa; Gen Kondoh; Yin C Lin; Hiroyuki Ogata; Masaki Miyazaki

  Science immunology, 04 Sep. 2020

  
• RNA Recognition and Immunity-Innate Immune Sensing and Its Posttranscriptional Regulation Mechanisms.

  Takuya Uehata; Osamu Takeuchi

  Cells, 16 Jul. 2020

  
• Translation-dependent unwinding of stem-loops by UPF1 licenses Regnase-1 to degrade inflammatory mRNAs.

  Takashi Mino; Noriki Iwai; Masayuki Endo; Kentaro Inoue; Kotaro Akaki; Fabian Hia; Takuya Uehata; Tomoko Emura; Kumi Hidaka; Yutaka Suzuki; Daron M Standley; Mariko Okada-Hatakeyama; Shigeo Ohno; Hiroshi Sugiyama; Akio Yamashita; Osamu Takeuchi

  Nucleic acids research, 19 Sep. 2019

  Access this paper :

  
• N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation.

  Daichi Yamasoba; Kei Sato; Takuya Ichinose; Tomoko Imamura; Lennart Koepke; Simone Joas; Elisabeth Reith; Dominik Hotter; Naoko Misawa; Kotaro Akaki; Takuya Uehata; Takashi Mino; Sho Miyamoto; Takeshi Noda; Akio Yamashita; Daron M Standley; Frank Kirchhoff; Daniel Sauter; Yoshio Koyanagi; Osamu Takeuchi

  Nature microbiology, Sep. 2019

  Access this paper :

  
• NET-CAGE characterizes the dynamics and topology of human transcribed cis-regulatory elements.

  Shigeki Hirabayashi; Shruti Bhagat; Yu Matsuki; Yujiro Takegami; Takuya Uehata; Ai Kanemaru; Masayoshi Itoh; Kotaro Shirakawa; Akifumi Takaori-Kondo; Osamu Takeuchi; Piero Carninci; Shintaro Katayama; Yoshihide Hayashizaki; Juha Kere; Hideya Kawaji; Yasuhiro Murakawa

  Nature genetics, Sep. 2019

  
• Phosphorylation-dependent Regnase-1 release from endoplasmic reticulum is critical in IL-17 response.

  Hiroki Tanaka; Yasunobu Arima; Daisuke Kamimura; Yuki Tanaka; Noriyuki Takahashi; Takuya Uehata; Kazuhiko Maeda; Takashi Satoh; Masaaki Murakami; Shizuo Akira

  The Journal of experimental medicine, 03 Jun. 2019

  
• Pulmonary Regnase-1 orchestrates the interplay of epithelium and adaptive immune systems to protect against pneumonia.

  Yoshinari Nakatsuka; Alexis Vandenbon; Takashi Mino; Masanori Yoshinaga; Takuya Uehata; Xiaotong Cui; Ayuko Sato; Tohru Tsujimura; Yutaka Suzuki; Atsuyasu Sato; Tomohiro Handa; Kazuo Chin; Teiji Sawa; Toyohiro Hirai; Osamu Takeuchi

  Mucosal immunology, Jul. 2018

  
• Regnase-1 and Roquin Nonredundantly Regulate Th1 Differentiation Causing Cardiac Inflammation and Fibrosis.

  Xiaotong Cui; Takashi Mino; Masanori Yoshinaga; Yoshinari Nakatsuka; Fabian Hia; Daichi Yamasoba; Tohru Tsujimura; Keizo Tomonaga; Yutaka Suzuki; Takuya Uehata; Osamu Takeuchi

  Journal of immunology (Baltimore, Md. : 1950), 15 Dec. 2017

  
• Regnase-1 Maintains Iron Homeostasis via the Degradation of Transferrin Receptor 1 and Prolyl-Hydroxylase-Domain-Containing Protein 3 mRNAs.

  Masanori Yoshinaga; Yoshinari Nakatsuka; Alexis Vandenbon; Daisuke Ori; Takuya Uehata; Tohru Tsujimura; Yutaka Suzuki; Takashi Mino; Osamu Takeuchi

  Cell reports, 23 May 2017

  Access this paper :

  
• Regnase-1 Is an Endoribonuclease Essential for the Maintenance of Immune Homeostasis.

  Takuya Uehata; Osamu Takeuchi

  Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, May 2017

  
• Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms.

  Takashi Mino; Yasuhiro Murakawa; Akira Fukao; Alexis Vandenbon; Hans-Hermann Wessels; Daisuke Ori; Takuya Uehata; Sarang Tartey; Shizuo Akira; Yutaka Suzuki; Carola G Vinuesa; Uwe Ohler; Daron M Standley; Markus Landthaler; Toshinobu Fujiwara; Osamu Takeuchi

  Cell, 21 May 2015

  Access this paper :

  
• Malt1-induced cleavage of regnase-1 in CD4(+) helper T cells regulates immune activation.

  Takuya Uehata; Hidenori Iwasaki; Alexis Vandenbon; Kazufumi Matsushita; Eduardo Hernandez-Cuellar; Kanako Kuniyoshi; Takashi Satoh; Takashi Mino; Yutaka Suzuki; Daron M Standley; Tohru Tsujimura; Hiromi Rakugi; Yoshitaka Isaka; Osamu Takeuchi; Shizuo Akira

  Cell, 23 May 2013

  
• mRNA degradation by the endoribonuclease Regnase-1/ZC3H12a/MCPIP-1.

  Takuya Uehata; Shizuo Akira

  Biochimica et biophysica acta, 2013

  
• Serum hepcidin-25 levels predict the progression of renal anemia in patients with non-dialysis chronic kidney disease.

  Kakuya Niihata; Naohisa Tomosugi; Takuya Uehata; Tatsuya Shoji; Kensuke Mitsumoto; Morihiro Shimizu; Hiroaki Kawabata; Yusuke Sakaguchi; Akira Suzuki; Terumasa Hayashi; Noriyuki Okada; Yoshitaka Isaka; Hiromi Rakugi; Yoshiharu Tsubakihara

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, Dec. 2012

  
• Neutrophil extracellular traps mediate a host defense response to human immunodeficiency virus-1.

  Tatsuya Saitoh; Jun Komano; Yasunori Saitoh; Takuma Misawa; Michihiro Takahama; Tatsuya Kozaki; Takuya Uehata; Hidenori Iwasaki; Hiroko Omori; Shoji Yamaoka; Naoki Yamamoto; Shizuo Akira

  Cell host & microbe, 19 Jul. 2012

  
• Serum hepcidin-25 levels and anemia in non-dialysis chronic kidney disease patients: a cross-sectional study.

  Takuya Uehata; Naohisa Tomosugi; Tatsuya Shoji; Yusuke Sakaguchi; Akira Suzuki; Tetsuya Kaneko; Noriyuki Okada; Ryohei Yamamoto; Yasuyuki Nagasawa; Kiminori Kato; Yoshitaka Isaka; Hiromi Rakugi; Yoshiharu Tsubakihara

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, Mar. 2012

  
• Implantation of a Jarvik 2000 left ventricular assist device as a bridge to eligibility for refractory heart failure with renal dysfunction.

  Satoshi Kainuma; Taichi Sakaguchi; Shunsuke Saito; Shigeru Miyagawa; Yasushi Yoshikawa; Takashi Yamauchi; Yasushi Sakata; Atsushi Takahashi; Takuya Uehata; Toru Kuratani; Yoshiki Sawa

  Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs, Mar. 2012

  
• The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1.

  Hidenori Iwasaki; Osamu Takeuchi; Shunsuke Teraguchi; Kazufumi Matsushita; Takuya Uehata; Kanako Kuniyoshi; Takashi Satoh; Tatsuya Saitoh; Mutsuyoshi Matsushita; Daron M Standley; Shizuo Akira

  Nature immunology, 30 Oct. 2011

  
• An autopsy-proven case of myeloperoxidase-antineutrophil cytoplasmic antibody-positive polyarteritis nodosa with acute renal failure and alveolar hemorrhage.

  Yusuke Sakaguchi; Takuya Uehata; Hiroaki Kawabata; Kakuya Niihata; Akihiro Shimomura; Akira Suzuki; Tetsuya Kaneko; Tatsuya Shoji; Kohki Shimazu; Hiroaki Fushimi; Yoshiharu Tsubakihara

  Clinical and experimental nephrology, Apr. 2011

  
• Cigarette smoking and progression of IgA nephropathy.

  Ryohei Yamamoto; Yasuyuki Nagasawa; Tatsuya Shoji; Hirotsugu Iwatani; Takayuki Hamano; Noritaka Kawada; Kazunori Inoue; Takuya Uehata; Tetsuya Kaneko; Noriyuki Okada; Toshiki Moriyama; Masaru Horio; Atsushi Yamauchi; Yoshiharu Tsubakihara; Enyu Imai; Hiromi Rakugi; Yoshitaka Isaka

  American journal of kidney diseases : the official journal of the National Kidney Foundation, Aug. 2010

  
• A candidate gene approach to genetic prognostic factors of IgA nephropathy--a result of Polymorphism REsearch to DIstinguish genetic factors Contributing To progression of IgA Nephropathy (PREDICT-IgAN).

  Ryohei Yamamoto; Yasuyuki Nagasawa; Tatsuya Shoji; Kazunori Inoue; Takuya Uehata; Tetsuya Kaneko; Tomonori Okada; Atsushi Yamauchi; Yoshiharu Tsubakihara; Enyu Imai; Yoshitaka Isaka; Hiromi Rakugi

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, Dec. 2009

  
• [Autopsy case of PR3-ANCA-associated vasculitis complicated with rectus muscle hematoma].

  Yusuke Sakaguchi; Kakuya Niihata; Keiko Yasuda; Akihiro Shimomura; Takuya Uehata; Kazunori Inoue; Tetsuya Kaneko; Tatsuya Shoji; Yoshiharu Tsubakihara; Noriyuki Okada

  Nihon Jinzo Gakkai shi, 2009

  

Misc.

• Regulatory mechanism of Nfkbiz mRNA degradation in controlling the balance between lymphoid and myeloid lineages

  Takuya Uehata

  Journal of Clinical and Experimental Medicine, 22 Mar. 2025, Lead author

  
• 【RNAバイオロジーの最前線】RNA認識による自然免疫応答

  植畑 拓也; 竹内 理

  生化学, Dec. 2024

  
• RNA-mediated mechanisms to regulate viral infection and gene expression in the innate immune system

  Takuya Uehata; Osamu Takeuchi

  Seikagaku, Jun. 2018

  
• mRNA分解が制御する造血幹細胞の分化方向性決定機構

  植畑拓也; 竹内理

  臨床免疫・アレルギー科, Oct. 2024

  
• 【良い炎症・悪い炎症から捉え直す がんと免疫 】慢性炎症に関わる免疫細胞

  植畑 拓也

  実験医学, Jun. 2024

  
• 【自然免疫の最前線】自然免疫応答のプラットホーム RNA分解酵素による自然免疫応答のフィードバック制御

  植畑 拓也; 竹内 理

  医学のあゆみ, Jun. 2018

  
• 免疫学 T細胞におけるRegnase-1を介したあらたな転写後制御機構の解明

  植畑 拓也; 審良 静男

  医学のあゆみ, Jul. 2014

  
• Malt1を介したRegnase-1の分解はCD4 T細胞の活性化を制御する

  ライフサイエンス新着レビュー, 2013, Lead author

  
• 透析導入期に発見された悪性リンパ腫の1例

  神田 貴史; 植畑 拓也; 清水 一亘; 小尾 佳嗣; 新沢 真紀; 高橋 篤; 長澤 康行; 川田 典孝; 今井 圓裕; 猪阪 善隆

  大阪透析研究会会誌, Mar. 2010

  
• 腎性貧血患者における血中エリスロポエチン濃度の検討

  植畑 拓也; 坂口 悠介; 下村 明弘; 鈴木 朗; 金子 哲也; 勝二 達也; 山口 誓司; 岡田 倫之; 椿原 美治

  日本腎臓学会誌, Apr. 2009

  
• 【透析トラブルQ&A】腹痛の原因と対策について教えてください

  植畑 拓也

  腎と透析, May 2008

  
• 保存期腎不全患者におけるヘプシジンの検討

  植畑 拓也; 友杉 直久; 坂口 悠介; 下村 明弘; 井上 和則; 金子 哲也; 勝二 達也; 岡田 倫之; 椿原 美治

  日本腎臓学会誌, Apr. 2008

  
• 保存期慢性腎不全(CRF)におけるhepcidin25の動態

  植畑 拓也; 友杉 直久; 下村 明弘; 井上 和則; 金子 哲也; 勝二 達也; 椿原 美治

  日本内科学会雑誌, Feb. 2008

  
• Pulmonary Regnase-1 functions as a posttranscriptional switch in anti-bacterial immunity

  Yoshinari Nakatsuka; Takashi Mino; Masanori Yoshinaga; Takuya Uehata; Atsuyasu Sato; Tomohiro Handa; Kazuo Chin; Toyohiro Hirai Hirai; Osamu Takeuchi

  CYTOKINE, Dec. 2017

  

Presentations

• Regnase-1/3 controls hematopoietic lineage bias through degradation of Nfkbiz mRNA

  Takuya Uehata

  Cytokines 2024 & KAI 2024

  
• 1. The Regnase-1/3-Nfkbiz axis controls hematopoietic lineage priming

  Takuya Uehata

  JSICR/MMCB 2023 Joint Symposium

  
• 3. Critical roles of endonucleases Regnase-1 and Regnase-3 in early lymphopoiesis

  Takuya Uehata

  Keystone symposia (Transcription and RNA Regulation in Inflammation and Immunity)

  
• 4. Malt-1 Mediated Cleavage of Regnase-1 Regulates CD4 T Activation

  Takuya Uehata

  Keystone symposia (The NF-kappaB System in Health and Disease)

  

Industrial Property Rights

• 特願PCT/JP2023/020104, がんを処置するための組成物

  植畑拓也; 竹内理

  

External funds: Kakenhi

• Elucidation of a Novel Mechanism of Regnase-1-mediated mRNA Decay via Ubiquitination

  Grant-in-Aid for Scientific Research (C)

  Basic Section 49070:Immunology-related

  Kyoto University

  Takuya Uehata

  From 01 Apr. 2021, To 31 Mar. 2024, Project Closed

  ユビキチン化;mRNA分解;T細胞;自己抗体;ユビキチン;炎症制御;転写後制御;炎症

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K07079/
• Identification of Symbiotic Communication between Artificial Nucleic Acids and Human Immune Systems

  Grant-in-Aid for Transformative Research Areas (A)

  Transformative Research Areas, Section (II)

  Institute of Science Tokyo;Nagasaki University

  Asako Yamayoshi

  From 19 Nov. 2020, To 31 Mar. 2025, Project Closed

  核酸医薬;非天然核酸;免疫応答;エクソソーム;細胞外小胞;物質共生;免疫反応;毒性;弱い相互作用;人工核酸;DDS;抗体産生

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-20H05874/
• Biophysical Chemistry for Material Symbiosis

  Grant-in-Aid for Transformative Research Areas (A)

  Transformative Research Areas, Section (II)

  Nagasaki University

  山吉 麻子

  From 19 Nov. 2020, To 31 Mar. 2025, Granted

  物質共生;弱い相互作用;マテリアル・シンバイオシス;免疫反応;生体適合性材料;マテリアル　シンバイオシス;物理化学;シンバイオティックマテリアル;シンバイオティクス;マテリアル・シンバオシス;シンバイオティックス

  https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-20H05871/
• Elucidation of a novel posttranscriptional mechanism regulating early lymphopoiesis

  Grant-in-Aid for Early-Career Scientists

  Basic Section 49070:Immunology-related

  Kyoto University

  Takuya Uehata

  From 01 Apr. 2018, To 31 Mar. 2021, Project Closed

  転写後制御;mRNA分解;造血幹細胞;細胞系譜決定;lineage priming;lineage bias;RNA分解;single cell RNA seq;リンパ球初期分化;RNA結合タンパク質

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K15185/
• Analysis of immune regulatory mechanisms mediated by mRNA metabolism

  Grant-in-Aid for Scientific Research (S)

  Broad Section H

  Kyoto University

  Osamu Takeuchi

  From 11 Jun. 2018, To 31 Mar. 2023, Project Closed

  炎症性疾患;mRNA分解;核酸医薬;免疫細胞分化;mRNA修飾;自然免疫応答;mRNA制御;ｍRNA分解;免疫応答;サイトカイン;免疫制御

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H05278/
• Comprehensive analysis of RNA binding proteins in the immune system

  Grant-in-Aid for Research Activity Start-up

  Kyoto University

  Takuya Uehata

  From 26 Aug. 2016, To 31 Mar. 2018, Project Closed

  RNA結合蛋白質;転写後制御;炎症制御;RNA結合タンパク質;RNA結合タンパク;RBPome;免疫細胞;プロテオーム;免疫学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H06898/
• 新規リボヌクレアーゼRegnase-1を標的とした泌尿器がん新規免疫療法の開発

  Grant-in-Aid for Scientific Research (C)

  Basic Section 56030:Urology-related

  Osaka University

  吉村 明洋

  From 01 Apr. 2024, To 31 Mar. 2027, Granted

  腎癌;免疫療法;Regnase-1

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K12437/