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Shimba, Akihiro
Graduate School of Medicine Program-Specific Assistant Professor
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Last Updated :2025/05/02
Basic Information
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J-Global ID
Researcher number
30812242
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Last Updated :2025/05/02
Research
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Papers
- The transcription factor RORα is required for the development of type 1 innate lymphoid cells in adult bone marrowShinya Abe; Moe Kagao; Takuma Asahi; Ryoma Kato; Shizue Tani-ichi; Akihiro Shimba; Riki Ishibashi; Hitoshi Miyachi; Satsuki Kitano; Masaki Miyazaki; Hans-Reimer Rodewald; Fumiko Toyoshima; Koichi IkutaThe Journal of Immunology, 13 Mar. 2025
- A Chimeric IL-7Rα/IL-2Rβ Receptor Promotes the Differentiation of T Cell Progenitors into B Cells and Type 2 Innate Lymphoid Cells.Akihiro Shimba; Shizue Tani-Ichi; Kyoko Masuda; Guangwei Cui; Satoru Munakata; Shinya Abe; Satsuki Kitano; Hitoshi Miyachi; Hiroshi Kawamoto; Koichi IkutaJournal of immunology (Baltimore, Md. : 1950), 14 Aug. 2024
- Hematopoietic cell-derived IL-15 supports NK cell development in scattered and clustered localization within the bone marrow.Shinya Abe; Takuma Asahi; Takahiro Hara; Guangwei Cui; Akihiro Shimba; Shizue Tani-Ichi; Kohei Yamada; Kazuko Miyazaki; Hitoshi Miyachi; Satsuki Kitano; Naotoshi Nakamura; Junichi Kikuta; Alexis Vandenbon; Masaki Miyazaki; Ryo Yamada; Toshiaki Ohteki; Masaru Ishii; Veronika Sexl; Takashi Nagasawa; Koichi IkutaCell reports, 10 Sep. 2023
- CD45 alleviates airway inflammation and lung fibrosis by limiting expansion and activation of ILC2s.Guangwei Cui; Akihiro Shimba; Jianshi Jin; Nozomi Hojo; Takuma Asahi; Shinya Abe; Aki Ejima; Shinri Okada; Keizo Ohira; Ryoma Kato; Shizue Tani-Ichi; Ryo Yamada; Takashi Ebihara; Katsuyuki Shiroguchi; Koichi IkutaProceedings of the National Academy of Sciences of the United States of America, 05 Sep. 2023
- Lung group 2 innate lymphoid cells differentially depend on local IL-7 for their distribution, activation, and maintenance in innate and adaptive immunity-mediated airway inflammation.Daichi Takami; Shinya Abe; Akihiro Shimba; Takuma Asahi; Guangwei Cui; Shizue Tani-Ichi; Takahiro Hara; Keishi Miyata; Masashi Ikutani; Kiyoshi Takatsu; Yuichi Oike; Koichi IkutaInternational immunology, 26 Jul. 2023
- 肺における2型自然リンパ球の維持と活性化に対するIL-7の機能(Role of local IL-7 in maintenance and activation of lung ILC2)高見 大地; 阿部 真也; 榛葉 旭恒; 旭 拓真; 生田 宏一日本細胞生物学会大会講演要旨集, Jun. 2020
- Liver type 1 innate lymphoid cells lacking IL-7 receptor are a native killer cell subset fostered by parenchymal niches.Takuma Asahi; Shinya Abe; Guangwei Cui; Akihiro Shimba; Tsukasa Nabekura; Hitoshi Miyachi; Satsuki Kitano; Keizo Ohira; Johannes M Dijkstra; Masaki Miyazaki; Akira Shibuya; Hiroshi Ohno; Koichi IkutaeLife, 22 Jun. 2023
- Physiological concentrations of glucocorticoids induce pathological
DNA double‐strand breaksSalma Akter; Akihiro Shimba; Koichi Ikuta; Md. Rasel Al Mahmud; Shintaro Yamada; Hiroyuki Sasanuma; Masataka Tsuda; Masakatsu Sone; Yukio Ago; Kenichi Murai; Hisashi Tanaka; Shunichi TakedaGenes to Cells, 07 Dec. 2022 - Control of immunity and allergy by steroid hormonesKoichi Ikuta; Aki Ejima; Shinya Abe; Akihiro ShimbaAllergology International, Oct. 2022
- A circulating subset of iNKT cells mediates antitumor and antiviral immunity.Guangwei Cui; Akihiro Shimba; Jianshi Jin; Taisaku Ogawa; Yukiko Muramoto; Hitoshi Miyachi; Shinya Abe; Takuma Asahi; Shizue Tani-Ichi; Johannes M Dijkstra; Yayoi Iwamoto; Kirill Kryukov; Yuanbo Zhu; Daichi Takami; Takahiro Hara; Satsuki Kitano; Yan Xu; Hajime Morita; Moyu Zhang; Lynn Zreka; Keishi Miyata; Takashi Kanaya; Shinya Okumura; Takashi Ito; Etsuro Hatano; Yoshimasa Takahashi; Hiroshi Watarai; Yuichi Oike; Tadashi Imanishi; Hiroshi Ohno; Toshiaki Ohteki; Nagahiro Minato; Masato Kubo; Georg A Holländer; Hideki Ueno; Takeshi Noda; Katsuyuki Shiroguchi; Koichi IkutaScience immunology, 28 Oct. 2022
- Androgens Alleviate Allergic Airway Inflammation by Suppressing Cytokine Production in Th2 Cells.Aki Ejima; Shinya Abe; Akihiro Shimba; Susumu Sato; Takuya Uehata; Shizue Tani-Ichi; Satoru Munakata; Guangwei Cui; Osamu Takeuchi; Toyohiro Hirai; Shigeaki Kato; Koichi IkutaJournal of immunology (Baltimore, Md. : 1950), 17 Aug. 2022
- 【免疫系の概日リズム】グルココルチコイドによる免疫応答能の概日制御榛葉 旭恒; 生田 宏一医学のあゆみ, Apr. 2022
- Control of immunity by glucocorticoids in health and diseaseAkihiro Shimba; Koichi IkutaSeminars in Immunopathology, Dec. 2020
- Immune-enhancing effects of glucocorticoids in response to day–night cycles and stressAkihiro Shimba; Koichi IkutaInternational Immunology, 20 Oct. 2020
- Glucocorticoids Regulate Circadian Rhythm of Innate and Adaptive ImmunityAkihiro Shimba; Koichi IkutaFrontiers in Immunology, 18 Sep. 2020
- Intestinal epithelial cell-derived IL-15 determines local maintenance and maturation of intra-epithelial lymphocytes in the intestine.Yuanbo Zhu; Guangwei Cui; Eiji Miyauchi; Yuki Nakanishi; Hisa Mukohira; Akihiro Shimba; Shinya Abe; Shizue Tani-Ichi; Takahiro Hara; Hiroshi Nakase; Tsutomu Chiba; Atsuko Sehara-Fujisawa; Hiroshi Seno; Hiroshi Ohno; Koichi IkutaInternational immunology, 08 May 2020, Peer-reviewed
- IL-7R-Dependent Phosphatidylinositol 3-Kinase Competes with the STAT5 Signal to Modulate T Cell Development and Homeostasis.Guangwei Cui; Akihiro Shimba; Guangyong Ma; Kazuhiko Takahara; Shizue Tani-Ichi; Yuanbo Zhu; Takuma Asahi; Akifumi Abe; Hitoshi Miyachi; Satsuki Kitano; Takahiro Hara; Jun-Ichirou Yasunaga; Hirotsugu Suwanai; Hisakata Yamada; Masao Matsuoka; Kohjiro Ueki; Yasunobu Yoshikai; Koichi IkutaJournal of immunology (Baltimore, Md. : 1950), 15 Feb. 2020, Peer-reviewed
- Chronic circadian misalignment accelerates immune senescence and abbreviates lifespan in mice.Hitoshi Inokawa; Yasuhiro Umemura; Akihiro Shimba; Eiryo Kawakami; Nobuya Koike; Yoshiki Tsuchiya; Munehiro Ohashi; Yoichi Minami; Guangwei Cui; Takuma Asahi; Ryutaro Ono; Yuh Sasawaki; Eiichi Konishi; Seung-Hee Yoo; Zheng Chen; Satoshi Teramukai; Koichi Ikuta; Kazuhiro YagitaScientific reports, 13 Feb. 2020, Peer-reviewed, Lead author
- Glucocorticoids Drive Diurnal Oscillations in T Cell Distribution and Responses by Inducing Interleukin-7 Receptor and CXCR4.Akihiro Shimba; Guangwei Cui; Shizue Tani-Ichi; Makoto Ogawa; Shinya Abe; Fumie Okazaki; Satsuki Kitano; Hitoshi Miyachi; Hisakata Yamada; Takahiro Hara; Yasunobu Yoshikai; Takashi Nagasawa; Günther Schütz; Koichi IkutaImmunity, 20 Feb. 2018, Peer-reviewed, Lead author
- グルココルチコイドと免疫概日リズムが制御する生体防御機構榛葉旭恒; 生田宏一医学のあゆみ, 2018, Invited
- グルココルチコイドによる免疫機能の日内変動の制御生田宏一; 榛葉旭恒アンチ・エイジング医学, 2018, Invited
- Interleukin-7 receptor controls development and maturation of late stages of thymocyte subpopulationsShizue Tani-ichi; Akihiro Shimba; Keisuke Wagatsuma; Hitoshi Miyachi; Satsuki Kitano; Kumiko Imai; Takahiro Hara; Koichi IkutaPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jan. 2013, Peer-reviewed
Misc.
- 肝臓内IL-15産生性微小環境による1型自然リンパ球を介した抗腫瘍免疫の制御旭拓真; 榛葉旭恒; 崔広為; 阿部真也; 生田宏一日本分子生物学会年会プログラム・要旨集(Web), 2020
- Pleiotropic Effects of Glucocorticoids on the Immune System in Circadian Rhythm and StressAkihiro Shimba; Aki Ejima; Koichi IkutaFrontiers in Immunology, 08 Oct. 2021
- Glucocorticoids Drive Circadian Changes in T-Cell Homing and Response via IL-7 ReceptorAkihiro Shimba; Koichi IkutaJOURNAL OF IMMUNOLOGY, May 2017
Presentations
- Glucocorticoids drive diurnal changes in distribution and response of T cells via IL-7R expressionShimba Akihiro; Cui Guangwei; Ikuta Koichi第46回日本免疫学会総会・学術集会, Dec. 2017
- Glucocorticoids drive diurnal changes in distribution and response of T cells via IL-7R expressionShimba Akihiro; Ikuta Koichi24th East Asia Joint Symposium, Oct. 2017
- グルココルチコイドによる IL-7R および CXCR4 の発現を介した T 細胞維持への影響榛葉 旭恒; 生田 宏一Kyoto T Cell Conference, May 2015
- Differential roles of IL-7 and IL-2 receptor signals in lymphocyte development and maintenance revealed by IL-7Rα/IL-15Rβ chimera knock-inAkihiro Shimba; Shizue Tani-Ichi; Kyoko Masuda; Takahiro Hara; Hiroshi Kawamoto; Koichi Ikuta第43回日本免疫学会総会・学術集会, Dec. 2014
Books and Other Publications
- グルココルチコイドによる免疫応答の日内変動制御榛葉 旭恒; 生田宏一感染炎症免疫, Aug. 2019, Not refereed
- 概日リズムが制御する免疫応答の日内変動と炎症疾患榛葉 旭恒; 生田宏一実験医学, Feb. 2019, Not refereed
- グルココルチコイドによる正負の免疫制御榛葉 旭恒; 生田宏一生体の科学, 2019, Not refereed
- グルココルチコイドと免疫概日リズムが制御する生体防御機構榛葉 旭恒; 生田 宏一医学のあゆみ, Sep. 2018, Not refereed
- グルココルチコイドによる免疫機能の日内変動の制御生田 宏一; 榛葉 旭恒アンチ・エイジング医学, Aug. 2018, Not refereed
External funds: Kakenhi
- Induction of autoimmune diseases by glucocorticoidsGrant-in-Aid for Challenging Research (Exploratory)Medium-sized Section 49:Pathology, infection/immunology, and related fieldsKyoto UniversityKoichi IKUTAFrom 30 Jul. 2020, To 31 Mar. 2022, Project Closedグルココルチコイド;自己免疫疾患;Th17細胞;実験的自己免疫性脳脊髄炎;関節リウマチ
- Stress-induced renin causes intestinal inflammation via helper T cellsGrant-in-Aid for Early-Career ScientistsBasic Section 49070:Immunology-relatedKyoto UniversityAkihiro ShimbaFrom 01 Apr. 2020, To 31 Mar. 2022, Project Closedレニン;ヘルパーT細胞;炎症性腸疾患;精神的ストレス;TH17細胞;大腸炎
- IL-15-producing microenvironment supporting innate lymphoid cells and its role in diseasesGrant-in-Aid for Scientific Research (B)Basic Section 49070:Immunology-relatedKyoto UniversityKoichi IkutaFrom 01 Apr. 2020, To 31 Mar. 2023, Project Closed自然免疫;サイトカイン;微小環境;IL-15;腫瘍免疫
- Glucocorticoids enhance the differentiation and function of Th17 cells and cause colitisGrant-in-Aid for Early-Career ScientistsBasic Section 49070:Immunology-relatedKyoto UniversityAkihiro ShimbaFrom 01 Apr. 2018, To 31 Mar. 2020, Project Closedグルココルチコイド;ストレス;Th17細胞;大腸炎;ILC3;ステロイドホルモン;ＴＨ17;炎症性腸疾患
- ストレスがTH17細胞のプロテアーゼの発現上昇と関節炎増悪に寄与する機構の解明Grant-in-Aid for Scientific Research (C)Basic Section 49070:Immunology-relatedKyoto University榛葉 旭恒From 01 Apr. 2022, To 31 Mar. 2025, Grantedストレス;ヘルパーT細胞;MMP25;TH17;マトリックスメタロプロテアーゼ;関節リウマチ
- Control of immune response and tissue homeostasis by novel IL-15-dependent subsets of innate lymphocytes and lymphoid cellsGrant-in-Aid for Scientific Research (B)Basic Section 49070:Immunology-relatedKyoto University生田 宏一From 01 Apr. 2023, To 31 Mar. 2026, Granted自然免疫;サイトカイン;微小環境;腫瘍免疫;抗ウイルス免疫応答
- Development of nighttime lighting to promote patient sleep under metameric conditionsGrant-in-Aid for Challenging Research (Exploratory)Medium-sized Section 58:Society medicine, nursing, and related fieldsKyoto University若村 智子From 30 Jun. 2023, To 31 Mar. 2025, Granted条件等色;概日リズム;看護ケア;照明機器;メラノプシン網膜神経節細胞
- Control of immune response and tissue homeostasis by novel IL-15-dependent innate lymphocytesGrant-in-Aid for Scientific Research (B)Basic Section 49070:Immunology-relatedKyoto University生田 宏一From 01 Apr. 2023, To 31 Mar. 2026, Granted自然免疫;サイトカイン;微小環境;腫瘍免疫;抗ウイルス免疫応答
list
Last Updated :2025/05/02
Education
Teaching subject(s)
- From 01 Apr. 2024, To 31 Mar. 2025Practice of Infectious disease medicine8028, Fall, Faculty of Medicine, 1
- From 01 Apr. 2024, To 31 Mar. 2025Physiology Practice3241, Fall, Faculty of Medicine, 1
- From 01 Apr. 2024, To 31 Mar. 2025Learning Clinical Laboratory Medicine in Hospital8043, Fall, Faculty of Medicine, 8
- From 01 Apr. 2023, To 31 Mar. 2024Practice of Infectious disease medicine8028, Fall, Faculty of Medicine, 1
- From 01 Apr. 2023, To 31 Mar. 2024Physiology Practice3241, Fall, Faculty of Medicine, 1
- From 01 Apr. 2023, To 31 Mar. 2024Immunology training8032, Fall, Faculty of Medicine, 1
- From 01 Apr. 2023, To 31 Mar. 2024Learning Clinical Laboratory Medicine in Hospital8043, Fall, Faculty of Medicine, 8
- From 01 Apr. 2022, To 31 Mar. 2023Physiology Practice3241, Fall, Faculty of Medicine, 1
- From 01 Apr. 2022, To 31 Mar. 2023Practice of Infectious disease medicine8028, Fall, Faculty of Medicine, 1
- From 01 Apr. 2022, To 31 Mar. 2023Learning Clinical Laboratory Medicine in Hospital8043, Fall, Faculty of Medicine, 8
- From 01 Apr. 2022, To 31 Mar. 2023Immunology training8032, Fall, Faculty of Medicine, 1
- From Apr. 2020, To Mar. 2021Immunology IFall, 医学部（人間健康科学科）
- From Apr. 2020, To Mar. 2021Learning Clinical Laboratory Medicine in HospitalFall, 医学部（人間健康科学科）
- From Apr. 2021, To Mar. 2022Immunology IFall, 医学部（人間健康科学科）
- From Apr. 2021, To Mar. 2022Immunology trainingFall, 医学部（人間健康科学科）
- From Apr. 2021, To Mar. 2022Practice of Infectious disease medicineFall, 医学部（人間健康科学科）
- From Apr. 2021, To Mar. 2022Physiology PracticeFall, 医学部（人間健康科学科）
- From Apr. 2021, To Mar. 2022Learning Clinical Laboratory Medicine in HospitalFall, 医学部（人間健康科学科）
