Basic Information

Email Address

• Email Address

  sakai.madoka.4zkyoto-u.ac.jp

Academic Degree

• 23 Mar. 2021

  京都大学博士（生命科学）
• 26 Mar. 2018

  京都大学修士（生命科学）

Academic Resume (Graduate Schools)

• 京都大学大学院, 生命科学研究科修士課程高次生命科学専攻, 修了
• 京都大学大学院, 生命科学研究科博士後期課程高次生命科学専攻, 修了

Academic Resume (Undergraduate School/Majors)

• 長浜バイオ大学, バイオサイエンス学部バイオサイエンス学科, 卒業

ID,URL

• J-Global ID

  202101007234689582

researchmap URL

• https://researchmap.jp/sakai-madoka

Research

Papers

• Distinct 5' UTR Requirements for Translation of the Bicistronic X/P mRNA Among Avian Orthobornaviruses.

  Meng-Chi Wu; Takehiro Kanda; Ryo Komorizono; Madoka Sakai; Alexander Leacy; Leonardo Susta; Akiko Makino; Keizo Tomonaga

  Microbiology and immunology, 07 Dec. 2025

  
• A single amino acid substitution in the Borna disease virus glycoprotein enhances the infectivity titer of vesicular stomatitis virus pseudotyped virus by altering membrane fusion activity.

  Yusa Akiba; Hiromichi Matsugo; Takehiro Kanda; Modoka Sakai; Akiko Makino; Keizo Tomonaga

  Microbiology and immunology, Nov. 2024

  
• Genome-scale CRISPR-Cas9 screen identifies host factors as potential therapeutic targets for SARS-CoV-2 infection.

  Madoka Sakai; Yoshie Masuda; Yusuke Tarumoto; Naoyuki Aihara; Yugo Tsunoda; Michiko Iwata; Yumiko Kamiya; Ryo Komorizono; Takeshi Noda; Kosuke Yusa; Keizo Tomonaga; Akiko Makino

  iScience, 16 Aug. 2024, Peer-reviewed

  
• Efficacy of oligodendrocyte precursor cells as delivery vehicles for single-chain variable fragment to misfolded SOD1 in ALS rat model

  Sumio Minamiyama; Madoka Sakai; Yuko Yamaguchi; Makiko Kusui; Hideki Wada; Ryota Hikiami; Yoshitaka Tamaki; Megumi Asada-Utsugi; Akemi Shodai; Akiko Makino; Noriko Fujiwara; Takashi Ayaki; Takakuni Maki; Hitoshi Warita; Masashi Aoki; Keizo Tomonaga; Ryosuke Takahashi; Makoto Urushitani

  Molecular Therapy - Methods & Clinical Development, Feb. 2023, Peer-reviewed

  
• Exogenous expression of both matrix protein and glycoprotein facilitates infectious viral particle production of Borna disease virus 1

  Takehiro Kanda; Madoka Sakai; Akiko Makino; Keizo Tomonaga

  Journal of General Virology, 12 Jul. 2022

  
• Stability of Borna disease virus-based episomal vector under physical and chemical stimulation.

  Mako Yanai; Madoka Sakai; Ryo Komorizono; Akiko Makino; Keizo Tomonaga

  Microbiology and immunology, Jan. 2022

  
• Optimal Expression of the Envelope Glycoprotein of Orthobornaviruses Determines the Production of Mature Virus Particles

  Madoka Sakai; Yoko Fujita; Ryo Komorizono; Takehiro Kanda; Yumiko Komatsu; Takeshi Noda; Keizo Tomonaga; Akiko Makino

  Journal of Virology, 02 Dec. 2020, Peer-reviewed, Lead author

  
• ADAR2 Is Involved in Self and Nonself Recognition of Borna Disease Virus Genomic RNA in the Nucleus

  Mako Yanai; Shohei Kojima; Madoka Sakai; Ryo Komorizono; Keizo Tomonaga; Akiko Makino

  Journal of Virology, 18 Dec. 2019, Peer-reviewed

  
• Respirovirus C protein inhibits activation of type I interferon receptor‐associated kinases to block JAK‐STAT signaling

  Yoshinori Kitagawa; Mayu Yamaguchi; Miki Kohno; Madoka Sakai; Masae Itoh; Bin Gotoh

  FEBS letters, Nov. 2019, Peer-reviewed

  
• 外来蛋白質を持続発現するボルナウイルスベクターの新たなアルツハイマー病治療戦略

  上田 紗希帆; 酒井 まどか; 大東 卓史; 浅田 めぐみ; 小松 弓子; 眞木 崇州; 葛谷 聡; 木下 彩栄; 高橋 良輔; 牧野 晶子; 朝長 啓造

  Dementia Japan, Sep. 2018

  
• Degradation of amyloid β peptide by neprilysin expressed from Borna disease virus vector

  Madoka Sakai; Sakiho Ueda; Takuji Daito; Megumi Asada-Utsugi; Yumiko Komatsu; Ayae Kinoshita; Takakuni Maki; Akira Kuzuya; Ryosuke Takahashi; Akiko Makino; Keizo Tomonaga

  Microbiology and Immunology, Jul. 2018, Peer-reviewed, Lead author

  
• Nonstructural protein of severe fever with thrombocytopenia syndrome phlebovirus targets STAT2 and not STAT1 to inhibit type I interferon-stimulated JAK-STAT signaling

  Yoshinori Kitagawa; Madoka Sakai; Masayuki Shimojima; Masayuki Saijo; Masae Itoh; Bin Gotoh

  Microbes and Infection, Jun. 2018, Peer-reviewed

  
• Dual function of the nuclear export signal of the Borna disease virus nucleoprotein in nuclear export activity and binding to viral phosphoprotein

  Mako Yanai; Madoka Sakai; Akiko Makino; Keizo Tomonaga

  Virology Journal, Dec. 2017, Peer-reviewed

  
• Human Metapneumovirus M2-2 Protein Acts as a Negative Regulator of Alpha Interferon Production by Plasmacytoid Dendritic Cells

  Yoshinori Kitagawa; Madoka Sakai; Mariko Funayama; Masae Itoh; Bin Gotoh

  Journal of Virology, 15 Oct. 2017, Peer-reviewed

  
• Antiviral activity of favipiravir (T-705) against mammalian and avian bornaviruses

  Tomoya Tokunaga; Yusuke Yamamoto; Madoka Sakai; Keizo Tomonaga; Tomoyuki Honda

  Antiviral Research, Jul. 2017, Peer-reviewed

  

Misc.

• Improvement of the production of Borna disease virus vector

  A. Makino; R. Komorizono; M. Sakai; K. Tomonaga

  HUMAN GENE THERAPY, Nov. 2016

  

Awards

• 19 May 2018

  ベストポスター賞
• 28 Jul. 2018

  Meritorious Abstract Travel Award

External funds: Kakenhi

• Altering Host Behavior with Persistent Infectious RNA Viruses

  Grant-in-Aid for Research Activity Start-up

  0702:Biology at cellular to organismal levels, and related fields

  Kyoto University

  Madoka Sakai

  From 30 Aug. 2021, To 31 Mar. 2023, Project Closed

  行動操作;ウイルス;感染伝播;生存戦略

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K20657/
• ウイルス間の相互作用による感染維持メカニズム

  Grant-in-Aid for Early-Career Scientists

  Basic Section 49060:Virology-related

  Kyoto University

  酒井 まどか

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  ウイルス間相互作用;持続感染;オルソボルナウイルス;社会ウイルス学;ボルナ病ウイルス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K14528/