Basic Information

Email Address

• Email Address

  sekine.yusuke.8fkyoto-u.ac.jp

Professional Memberships

• From 2005, To Present

  日本生化学会
• From 2004, To Present

  日本分子生物学会

Academic Degree

• 24 Mar. 2010

  東京大学博士（薬学）
• 24 Mar. 2007

  東京大学修士（薬学）

Academic Resume (Undergraduate School/Majors)

• 東京大学, 薬学部薬学科, 卒業

Research History

• From Apr. 2026, To Present

  Kyoto University, Gradate School of Pharmaceutical Sciences, Associate Professor
• From Oct. 2018, To Mar. 2026

  University of Pittsburgh, Aging Institute, Department of Medicine, Assistant Professor
• From Apr. 2016, To Sep. 2018

  National Institute of Health, NHLBI, Research Fellow
• From Apr. 2013, To Mar. 2016

  University of Cambridge, CIMR, Visiting Research Fellow
• From Apr. 2012, To Mar. 2013

  The University of Tokyo, Graduate School of Pharmaceutical Sciences, 助教
• From Apr. 2011, To Mar. 2012

  The University of Tokyo, Graduate School of Pharmaceutical Sciences, 特任助教
• From Apr. 2010, To Mar. 2011

  The University of Tokyo, Graduate School of Pharmaceutical Sciences, 特任研究員

ID,URL

• J-Global ID

  202301009903272851

• Researcher number

  00583981

researchmap URL

• https://researchmap.jp/yusukesekine

Research

Research Interests

• シグナル伝達
• オルガネラ
• Stress response

Research Areas

• Life sciences, Molecular biology, Stress response Signal transduction Organelle

Papers

• Inhibition of virally induced TFEB proteasomal degradation as a host-centric therapeutic approach for coronaviral infection.

  Travis B Lear; Mads B Larsen; Bo Lin; Benjamin R Treat; Qing Cao; Áine N Boudreau; Karina C Lockwood; Irene Alfaras; Jason R Kennerdell; Laura Salminen; Daniel P Camarco; Yao Tong; Jing Ma; Jie Liu; Jay X Tan; Ferhan Tuncer; John J Villandre; Lucas Hertzel; Michael M Myerburg; Yanwen Chen; Claudette St Croix; Yusuke Sekine; John W Evankovich; Simon M Barratt-Boyes; Toren Finkel; Bill B Chen; Yuan Liu

  Science advances, 06 Jun. 2025

  
• Metabolite tunes MDV pathway to maintain mitochondrial fitness.

  Shiori Sekine; Yusuke Sekine

  Molecular cell, 03 Apr. 2025

  
• OMA1 clears traffic jam in TOM tunnel in mammals.

  Shiori Sekine; Yusuke Sekine

  The Journal of cell biology, 06 May 2024

  
• A mitochondrial iron-responsive pathway regulated by DELE1.

  Yusuke Sekine; Ryan Houston; Eva-Maria Eckl; Evelyn Fessler; Derek P Narendra; Lucas T Jae; Shiori Sekine

  Molecular cell, 15 Jun. 2023

  
• Fluorescence Intensity-Based eIF2B's Guanine Nucleotide-Exchange Factor Activity Assay.

  Yusuke Sekine; David Ron; Alisa F Zyryanova

  Methods in molecular biology (Clifton, N.J.), 2022

  
• Discovery of bactericides as an acute mitochondrial membrane damage inducer.

  Ryan Houston; Yusuke Sekine; Mads B Larsen; Kei Murakami; Steven J Mullett; Stacy G Wendell; Derek P Narendra; Bill B Chen; Shiori Sekine

  Molecular biology of the cell, 01 Nov. 2021

  
• Modulation of lysosomal function as a therapeutic approach for coronaviral infections.

  Yuan Liu; Travis Lear; Mads Larsen; Bo Lin; Qing Cao; Irene Alfaras; Jason Kennerdell; Laura Salminen; Daniel Camarco; Karina Lockwood; Jing Ma; Jie Liu; Jay Tan; Michael Myerburg; Yanwen Chen; Claudette St Croix; Yusuke Sekine; John Evankovich; Toren Finkel; Bill Chen

  Research square, 23 Apr. 2021

  
• Cellular metabolic stress responses via organelles.

  Yusuke Sekine; Ryan Houston; Shiori Sekine

  Experimental cell research, 01 Mar. 2021

  
• Acetylation-mediated remodeling of the nucleolus regulates cellular acetyl-CoA responses.

  Ryan Houston; Shiori Sekine; Michael J Calderon; Fayaz Seifuddin; Guanghui Wang; Hiroyuki Kawagishi; Daniela A Malide; Yuesheng Li; Marjan Gucek; Mehdi Pirooznia; Alissa J Nelson; Matthew P Stokes; Jacob Stewart-Ornstein; Steven J Mullett; Stacy G Wendell; Simon C Watkins; Toren Finkel; Yusuke Sekine

  PLoS biology, Nov. 2020

  
• Sequential CRISPR-Based Screens Identify LITAF and CDIP1 as the Bacillus cereus Hemolysin BL Toxin Host Receptors.

  Jie Liu; Zehua Zuo; Inka Sastalla; Chengyu Liu; Ji Yong Jang; Yusuke Sekine; Yuesheng Li; Mehdi Pirooznia; Stephen H Leppla; Toren Finkel; Shihui Liu

  Cell host & microbe, 09 Sep. 2020

  
• Hyperlipidaemia and IFNgamma/TNFalpha Synergism are associated with cholesterol crystal formation in Endothelial cells partly through modulation of Lysosomal pH and Cholesterol homeostasis.

  Yvonne Baumer; Amit K Dey; Cristhian A Gutierrez-Huerta; Noor O Khalil; Yusuke Sekine; Gregory E Sanda; Jie Zhuang; Ankit Saxena; Erin Stempinski; Youssef A Elnabawi; Pradeep K Dagur; Qimin Ng; Heather L Teague; Andrew Keel; Justin A Rodante; William A Boisvert; Lam C Tsoi; Johann E Gudjonsson; Christopher K E Bleck; Marcus Y Chen; David A Bluemke; Joel M Gelfand; Daniella M Schwartz; Howard S Kruth; Tiffany M Powell-Wiley; Martin P Playford; Nehal N Mehta

  EBioMedicine, Sep. 2020

  
• The coupling of translational control and stress responses.

  Ryan Houston; Shiori Sekine; Yusuke Sekine

  Journal of biochemistry, 01 Aug. 2020

  
• Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B.

  Alisa F Zyryanova; Félix Weis; Alexandre Faille; Akeel Abo Alard; Ana Crespillo-Casado; Yusuke Sekine; Heather P Harding; Felicity Allen; Leopold Parts; Christophe Fromont; Peter M Fischer; Alan J Warren; David Ron

  Science (New York, N.Y.), 30 Mar. 2018

  
• KLHDC10 Deficiency Protects Mice against TNFα-Induced Systemic Inflammation.

  Namiko Yamaguchi; Shiori Sekine; Isao Naguro; Yusuke Sekine; Hidenori Ichijo

  PloS one, 2016

  
• Paradoxical Sensitivity to an Integrated Stress Response Blocking Mutation in Vanishing White Matter Cells.

  Yusuke Sekine; Alisa Zyryanova; Ana Crespillo-Casado; Niko Amin-Wetzel; Heather P Harding; David Ron

  PloS one, 2016

  
• Stress responses. Mutations in a translation initiation factor identify the target of a memory-enhancing compound.

  Yusuke Sekine; Alisa Zyryanova; Ana Crespillo-Casado; Peter M Fischer; Heather P Harding; David Ron

  Science (New York, N.Y.), 29 May 2015

  
• Apoptosis Signal-regulating Kinase 1 (ASK1)-p38 Pathway-dependent Cytoplasmic Translocation of the Orphan Nuclear Receptor NR4A2 Is Required for Oxidative Stress-induced Necrosis.

  Takeshi Watanabe; Shiori Sekine; Isao Naguro; Yusuke Sekine; Hidenori Ichijo

  The Journal of biological chemistry, 24 Apr. 2015

  
• Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity.

  M Halliday; H Radford; Y Sekine; J Moreno; N Verity; J le Quesne; C A Ortori; D A Barrett; C Fromont; P M Fischer; H P Harding; D Ron; G R Mallucci

  Cell death & disease, 05 Mar. 2015

  
• The DEAH-box RNA helicase DHX15 activates NF-κB and MAPK signaling downstream of MAVS during antiviral responses.

  Kenta Mosallanejad; Yusuke Sekine; Seiko Ishikura-Kinoshita; Kazuo Kumagai; Tetsuo Nagano; Atsushi Matsuzawa; Kohsuke Takeda; Isao Naguro; Hidenori Ichijo

  Science signaling, 29 Apr. 2014

  
• [Stress signaling and diseases via the ASK family kinases].

  Yusuke Sekine; Hidenori Ichijo

  Seikagaku. The Journal of Japanese Biochemical Society, Mar. 2013

  
• The Kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5.

  Yusuke Sekine; Ryo Hatanaka; Takeshi Watanabe; Naoki Sono; Shun-ichiro Iemura; Tohru Natsume; Erina Kuranaga; Masayuki Miura; Kohsuke Takeda; Hidenori Ichijo

  Molecular cell, 14 Dec. 2012

  
• Prevention of apoptosis by mitochondrial phosphatase PGAM5 in the mushroom body is crucial for heat shock resistance in Drosophila melanogaster.

  Yosuke Ishida; Yusuke Sekine; Haruka Oguchi; Takahiro Chihara; Masayuki Miura; Hidenori Ichijo; Kohsuke Takeda

  PloS one, 2012

  
• p38 MAPKs regulate the expression of genes in the dopamine synthesis pathway through phosphorylation of NR4A nuclear receptors.

  Yusuke Sekine; Shuichi Takagahara; Ryo Hatanaka; Takeshi Watanabe; Haruka Oguchi; Takuya Noguchi; Isao Naguro; Kazuto Kobayashi; Makoto Tsunoda; Takashi Funatsu; Hiroshi Nomura; Takeshi Toyoda; Norio Matsuki; Erina Kuranaga; Masayuki Miura; Kohsuke Takeda; Hidenori Ichijo

  Journal of cell science, 01 Sep. 2011

  
• Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1.

  Kohsuke Takeda; Yoshiko Komuro; Teruyuki Hayakawa; Haruka Oguchi; Yosuke Ishida; Shiori Murakami; Takuya Noguchi; Hideyuki Kinoshita; Yusuke Sekine; Shun-ichiro Iemura; Tohru Natsume; Hidenori Ichijo

  Proceedings of the National Academy of Sciences of the United States of America, 28 Jul. 2009

  
• The ASK1-MAP kinase signaling in ER stress and neurodegenerative diseases.

  Yusuke Sekine; Kohsuke Takeda; Hidenori Ichijo

  Current molecular medicine, Feb. 2006

  

External funds: Kakenhi

• アセチルCoA変動による核小体ストレス応答制御機構の解明

  Grant-in-Aid for Research Activity Start-up

  0701:Biology at molecular to cellular levels, and related fields

  Kyoto University

  関根 悠介

  From 31 Jul. 2026, To 31 Mar. 2028, Adopted

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26K24900/
• ストレスシグナルによるアポトーシスと炎症の選択的制御機構

  Grant-in-Aid for Young Scientists (B)

  The University of Tokyo

  関根 悠介

  From 01 Apr. 2012, To 31 Mar. 2013, Discontinued

  ストレスシグナル;ASK1;p38;核内受容体;Nurr1;酸化ストレス;細胞死

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790070/
• Regulation of nuclear receptor Nurr1 by stress-responsive signaling

  Grant-in-Aid for Research Activity Start-up

  The University of Tokyo

  Yusuke SEKINE

  From 01 Apr. 2010, To 31 Mar. 2012, Project Closed

  ストレス;シグナル伝達;核内受容体;ASK1;p38;Nurr1;ドパミン神経細胞;パーキンソン病

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22890031/

Education

Teaching subject(s)

• From 01 Apr. 2026, To 31 Mar. 2027

  Introduction to Biomedical Sciences

  U130, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2026, To 31 Mar. 2027

  Introduction to Pharmaceutical Biochemistry

  8103, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2026, To 31 Mar. 2027

  Introduction to Pharmaceutical Sciences

  6002, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2026, To 31 Mar. 2027

  Introduction to Modern Life Sciences for Drug Discovery

  1027, Spring, Graduate School of Pharmaceutical Sciences, 2