Basic Information

Email Address

• Email Address

  sumita.hiromi.8tkyoto-u.ac.jp

Academic Degree

• 22 Mar. 2018

  東京大学博士（薬科学）
• 24 Mar. 2015

  東京大学修士（薬科学）

Academic Resume (Graduate Schools)

• 東京大学, 大学院薬学系研究科博士課程薬科学専攻, 修了
• 東京大学, 大学院薬学系研究科修士課程薬科学専攻, 修了

Academic Resume (Undergraduate School/Majors)

• 東京大学, 薬学部薬科学科, 卒業

ID,URL

• J-Global ID

  202201009858779993

researchmap URL

• https://researchmap.jp/hiromisumita

Research

Papers

• A triggering structure of SARS-CoV-2 BA.2.86 spike upon ACE2 binding for receptor-binding domain up

  Takao Hashiguchi; Hisano Yajima; Yuki Anraku; Yu Kaku; Kanako Kimura; Arnon Plianchaisuk; Kaho Okumura; Yoshiko Nakada-Nakura; Shunsuke Kita; Jiei Sasaki; Hiromi Sumita; Jumpei Ito; Katsumi Maenaka; Kei Sato

  22 Mar. 2024

  
• Structural basis for receptor-binding domain mobility of the spike in SARS-CoV-2 BA.2.86 and JN.1

  Hisano Yajima; Yuki Anraku; Yu Kaku; Kanako Terakado Kimura; Arnon Plianchaisuk; Kaho Okumura; Yoshiko Nakada-Nakura; Yusuke Atarashi; Takuya Hemmi; Daisuke Kuroda; Yoshimasa Takahashi; Shunsuke Kita; Jiei Sasaki; Hiromi Sumita; Keita Matsuno; Naganori Nao; Hirofumi Sawa; Keita Mizuma; Jingshu Li; Izumi Kida; Yume Mimura; Yuma Ohari; Shinya Tanaka; Masumi Tsuda; Lei Wang; Yoshikata Oda; Zannatul Ferdous; Kenji Shishido; Hiromi Mohri; Miki Iida; Takasuke Fukuhara; Tomokazu Tamura; Rigel Suzuki; Saori Suzuki; Shuhei Tsujino; Hayato Ito; Naoko Misawa; Ziyi Guo; Alfredo A. Hinay; Kaoru Usui; Wilaiporn Saikruang; Spyridon Lytras; Keiya Uriu; Ryo Yoshimura; Shusuke Kawakubo; Luca Nishumura; Yusuke Kosugi; Shigeru Fujita; Jarel Elgin M.Tolentino; Luo Chen; Lin Pan; Wenye Li; Maximilian Stanley Yo; Kio Horinaka; Mai Suganami; Mika Chiba; Kyoko Yasuda; Keiko Iida; Adam Patrick Strange; Naomi Ohsumi; Shiho Tanaka; Eiko Ogawa; Tsuki Fukuda; Rina Osujo; Kazuhisa Yoshimura; Kenji Sadamas; Mami Nagashima; Hiroyuki Asakura; Isao Yoshida; So Nakagawa; Kazuo Takayama; Rina Hashimoto; Sayaka Deguchi; Yukio Watanabe; Yoshitaka Nakata; Hiroki Futatsusako; Ayaka Sakamoto; Naoko Yasuhara; Tateki Suzuki; Yukari Nakajima; Takashi Irie; Ryoko Kawabata; Kaori Sasaki-Tabata; Terumasa Ikeda; Hesham Nasser; Ryo Shimizu; M. S. T. Monira Begum; Michael Jonathan; Yuka Mugita; Sharee Leong; Otowa Takahashi; Takamasa Ueno; Chihiro Motozono; Mako Toyoda; Akatsuki Saito; Anon Kosaka; Miki Kawano; Natsumi Matsubara; Tomoko Nishiuchi; Jiri Zahradnik; Prokopios Andrikopoulos; Miguel Padilla-Blanco; Aditi Konar; Jumpei Ito; Katsumi Maenaka; Kei Sato; Takao Hashiguchi

  Nature Communications, 07 Oct. 2024

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• Nucleosides are endogenous ligands for TLR7 and TLR8

  Takuma Shibata; Umeharu Ohto; Hiromi Tanji; Toshiyuki Shimizu; Kensuke Miyake

  CYTOKINE, Dec. 2017, Peer-reviewed

  
• Tetrasubstituted imidazoles as incognito Toll-like receptor 8 a(nta)gonists.

  Yi Yang; Adam Csakai; Shuangshuang Jiang; Christina Smith; Hiromi Tanji; Jian Huang; Torey Jones; Kentaro Sakaniwa; Lindsey Broadwell; Chengrui Shi; Subada Soti; Umeharu Ohto; Yaohui Fang; Shu Shen; Fei Deng; Toshiyuki Shimizu; Hang Yin

  Nature communications, 16 Jul. 2021

  
• Rationally Designed Small-Molecule Inhibitors Targeting an Unconventional Pocket on the TLR8 Protein-Protein Interface.

  Shuangshuang Jiang; Hiromi Tanji; Kejun Yin; Shuting Zhang; Kentaro Sakaniwa; Jian Huang; Yi Yang; Jing Li; Umeharu Ohto; Toshiyuki Shimizu; Hang Yin

  Journal of medicinal chemistry, 23 Apr. 2020

  
• Small-Molecule TLR8 Antagonists via Structure-Based Rational Design.

  Zhenyi Hu; Hiromi Tanji; Shuangshuang Jiang; Shuting Zhang; Kyoin Koo; Jean Chan; Kentaro Sakaniwa; Umeharu Ohto; Albert Candia; Toshiyuki Shimizu; Hang Yin

  Cell chemical biology, 18 Oct. 2018

  
• Small-molecule inhibition of TLR8 through stabilization of its resting state.

  Shuting Zhang; Zhenyi Hu; Hiromi Tanji; Shuangshuang Jiang; Nabanita Das; Jing Li; Kentaro Sakaniwa; Jin Jin; Yanyan Bian; Umeharu Ohto; Toshiyuki Shimizu; Hang Yin

  Nature chemical biology, Jan. 2018

  
• Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA.

  Zhikuan Zhang; Umeharu Ohto; Takuma Shibata; Elena Krayukhina; Masato Taoka; Yoshio Yamauchi; Hiromi Tanji; Toshiaki Isobe; Susumu Uchiyama; Kensuke Miyake; Toshiyuki Shimizu

  Immunity, 18 Oct. 2016

  
• Identification of a Human Toll-Like Receptor (TLR) 8-Specific Agonist and a Functional Pan-TLR Inhibitor in 2-Aminoimidazoles.

  Mallesh Beesu; Giuseppe Caruso; Alex C D Salyer; Nijunj M Shukla; Karishma K Khetani; Luke J Smith; Lauren M Fox; Hiromi Tanji; Umeharu Ohto; Toshiyuki Shimizu; Sunil A David

  Journal of medicinal chemistry, 14 Apr. 2016

  
• Autoinhibition and relief mechanism by the proteolytic processing of Toll-like receptor 8.

  Hiromi Tanji; Umeharu Ohto; Yuji Motoi; Takuma Shibata; Kensuke Miyake; Toshiyuki Shimizu

  Proceedings of the National Academy of Sciences of the United States of America, 15 Mar. 2016

  
• Structure-Based Design of Human TLR8-Specific Agonists with Augmented Potency and Adjuvanticity.

  Mallesh Beesu; Giuseppe Caruso; Alex C D Salyer; Karishma K Khetani; Diptesh Sil; Mihiri Weerasinghe; Hiromi Tanji; Umeharu Ohto; Toshiyuki Shimizu; Sunil A David

  Journal of medicinal chemistry, 08 Oct. 2015

  
• Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9.

  Umeharu Ohto; Takuma Shibata; Hiromi Tanji; Hanako Ishida; Elena Krayukhina; Susumu Uchiyama; Kensuke Miyake; Toshiyuki Shimizu

  Nature, 30 Apr. 2015

  
• Toll-like receptor 8 senses degradation products of single-stranded RNA.

  Hiromi Tanji; Umeharu Ohto; Takuma Shibata; Masato Taoka; Yoshio Yamauchi; Toshiaki Isobe; Kensuke Miyake; Toshiyuki Shimizu

  Nature structural & molecular biology, Feb. 2015

  
• The Imidazoquinoline Toll-Like Receptor-7/8 Agonist Hybrid-2 Potently Induces Cytokine Production by Human Newborn and Adult Leukocytes.

  Lakshmi Ganapathi; Simon Van Haren; David J Dowling; Ilana Bergelson; Nikunj M Shukla; Subbalakshmi S Malladi; Rajalakshmi Balakrishna; Hiromi Tanji; Umeharu Ohto; Toshiyuki Shimizu; Sunil A David; Ofer Levy

  PloS one, 2015

  
• Determinants of activity at human Toll-like receptors 7 and 8: quantitative structure-activity relationship (QSAR) of diverse heterocyclic scaffolds.

  Euna Yoo; Deepak B Salunke; Diptesh Sil; Xiaoqiang Guo; Alex C D Salyer; Alec R Hermanson; Manoj Kumar; Subbalakshmi S Malladi; Rajalakshmi Balakrishna; Ward H Thompson; Hiromi Tanji; Umeharu Ohto; Toshiyuki Shimizu; Sunil A David

  Journal of medicinal chemistry, 09 Oct. 2014

  
• Structure-based design of novel human Toll-like receptor 8 agonists.

  Hari Prasad Kokatla; Diptesh Sil; Hiromi Tanji; Umeharu Ohto; Subbalakshmi S Malladi; Lauren M Fox; Toshiyoki Shimizu; Sunil A David

  ChemMedChem, Apr. 2014

  
• Structure and function of toll-like receptor 8.

  Umeharu Ohto; Hiromi Tanji; Toshiyuki Shimizu

  Microbes and infection, Apr. 2014

  
• Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands.

  Hiromi Tanji; Umeharu Ohto; Takuma Shibata; Kensuke Miyake; Toshiyuki Shimizu

  Science (New York, N.Y.), 22 Mar. 2013

  

Awards

• 08 Jul. 2016

  ロレアルユネスコ女性科学者日本奨励賞（日本ロレアル株式会社）
• 23 Mar. 2015

  東京大学総長大賞

Administration

Faculty management (title, position)

• From 01 Apr. 2026

  男女共同参画推進委員会　委員
• From 01 Apr. 2024

  広報委員会　委員
• From 01 Apr. 2024

  医生物学研究所　研究支援室　広報ユニット
• From 01 Apr. 2024

  医生物学研究所　研究支援室　共同研究拠点推進ユニット