Basic Information

Email Address

• Email Address

  chinnathambi.shanmugavel.8skyoto-u.ac.jp

Professional Memberships

• From Oct. 2017, To Present

  Indian JSPS Alumni Association

Academic Degree

• 30 Apr. 2007

  M．Sc（University of Madras）
• 05 Nov. 2014

  Ph．D（Anna University）

Academic Resume (Graduate Schools)

• Anna University, Medical Physics，Biomaterials，Ph.D, 修了
• University of Madras, Department of Crystallography and Biophysics, 修了

Academic Resume (Undergraduate School/Majors)

• Periyar Arts College, B．Sc in Physics, 卒業
• NLC Boys Higer Secondary School, 卒業

Research History

• From Mar. 2020, To Present

  Kyoto University, Institute for Integrated Cell - Material Sciences
• From Feb. 2018, To Feb. 2020

  National Institute for Materials Science, International Center for Young Scientists
• From Oct. 2015, To Sep. 2017

  JSPS Postdoctoral Research Fellow
• From Feb. 2015, To Sep. 2015

  National Institute for Materials Science, Nanotechnology Innovation Station

ID,URL

• ORCID ID

  0000-0001-9550-5367

• J-Global ID

  202101017110056749

• Researcher ID

  C-4760-2013

• Researcher number

  60922341

• External link

  https://shanmugavelchinnathambi.com/

Website(s) (URL(s))

• https://www.namasivayam.icems.kyoto-u.ac.jp/people
• https://shanmugavelchinnathambi.com/

researchmap URL

• https://researchmap.jp/shanmugavel

Research

Research Interests

• Silica Nanoparticles, Quantum dots, Drug delivery

Research Areas

• Nanotechnology/Materials, Nanobioscience, Quantum dots

Papers

• A biophysical approach of tyrphostin AG879 binding information in: bovine serum albumin, human ErbB2, c-RAF1 kinase, SARS-CoV-2 main protease and angiotensin-converting enzyme 2

  Subramani Karthikeyan; Anandh Sundaramoorthy; Saravanan Kandasamy; Ganesan Bharanidharan; Prakasarao Aruna; Ramakrishnamurthy Suganya; Rajendiran Mangaiyarkarasi; Singaravelu Ganesan; Ganesh N. Pandian; Anitha Ramamoorthi; Shanmugavel Chinnathambi

  Journal of Biomolecular Structure and Dynamics, 28 Apr. 2023, Peer-reviewed, Corresponding author

  
• A review on medicinally important heterocyclic compounds and importance of biophysical approach of underlying the insight mechanism in biological environment

  Subramani Karthikeyan; Maria Grishina; Saravanan Kandasamy; Rajendiran Mangaiyarkarasi; Anitha Ramamoorthi; Shanmugavel Chinnathambi; Ganesh N. Pandian; L. John Kennedy

  Journal of Biomolecular Structure and Dynamics, 13 Mar. 2023, Peer-reviewed

  
• Nano–bio interaction between human immunoglobulin G and nontoxic, near-infrared emitting water-borne silicon quantum dot micelles

  Shanmugavel Chinnathambi; Naoto Shirahata; Mahima Kumar; Subramani Karthikeyan; Katsuhiko Abe; Vaijayanthi Thangavel; Ganesh N. Pandian

  RSC Advances, Feb. 2023, Peer-reviewed, Lead author, Corresponding author

  
• A biophysical approach of cytarabine anticancer drug insights into human serum albumin and checkpoint kinase 1

  Manoharan Rupavarshini; Subramani Karthikeyan; Sundaramoorthy Anandh; Anitha Ramamoorthi; Suganya Ramakrishnamurthy; Ganesan Bharanidharan; Prakasarao Aruna; Rajendiran Mangaiyarkarasi; Shanmugavel Chinnathambi; Ganesh N. Pandian; Singaravelu Ganesan

  Results in Chemistry, Jan. 2023, Peer-reviewed

  
• Facile Synthesis of Hafnium Oxide Nanoparticle Decorated on Graphene Nanosheet and Its Photocatalytic Degradation of Organic Pollutants under UV-Light Irradiation

  Venkatachalam Jayaraman; Shanmugam Mahalingam; Shanmugavel Chinnathambi; Ganesh N. Pandian; Aruna Prakasarao; Singaravelu Ganesan; Jayavel Ramasamy; Sivasankaran Ayyaru; Young-Ho Ahn

  Applied Sciences, 05 Nov. 2022, Peer-reviewed, Corresponding author

  
• Iodine containing porous organosilica nanoparticles trigger tumor spheroids destruction upon monochromatic X-ray irradiation: DNA breaks and K-edge energy X-ray

  Yuya Higashi; Kotaro Matsumoto; Hiroyuki Saitoh; Ayumi Shiro; Yue Ma; Mathilde Laird; Shanmugavel Chinnathambi; Albane Birault; Tan Le Hoang Doan; Ryo Yasuda; Toshiki Tajima; Tetsuya Kawachi; Fuyuhiko Tamanoi

  Scientific Reports, Jul. 2021, Peer-reviewed

  
• A Compact Sensory Platform Based pH Sensor Using Graphene Field Effect Transistor

  Kumar Manoharan, Arun; Jayavel, Ramasamy; Shanmugam, Mahalingam; Sengottaiyan, Chinnasamy; Chinnathambi, Shanmugavel; Mohankumar, Nagarajan

  Journal of Nanoscience and Nanotechnology, Jun. 2021, Peer-reviewed

  
• A pilot study on parallel factor analysis as a diagnostic tool for oral cancer diagnosis: A statistical modeling approach

  Udayakumar Kanniyappan; Einstein Gnanatheepam; Karthikeyan Subramani; Mangaiyarkarasi Rajendran; Shanmugavel Chinnathambi; Prakasarao Aruna; Singaravelu Ganesan

  Journal of Chemometrics, Mar. 2021, Peer-reviewed

  
• Construction of Boronophenylalanine-Loaded Biodegradable Periodic Mesoporous Organosilica Nanoparticles for BNCT Cancer Therapy

  Fuyuhiko Tamanoi; Shanmugavel Chinnathambi; Mathilde Laird; Aoi Komatsu; Albane Birault; Takushi Takata; Tan Le-Hoang Doan; Ngoc Xuan Dat Mai; Arthur Raitano; Kendall Morrison; Minoru Suzuki; Kotaro Matsumoto

  International Journal of Molecular Sciences, 24 Feb. 2021, Peer-reviewed

  
• Nano-Bio Interaction between Blood Plasma Proteins and Water-Soluble Silicon Quantum Dots with Enabled Cellular Uptake and Minimal Cytotoxicity

  Shanmugavel Chinnathambi; Nobutaka Hanagata; Tomohiko Yamazaki; Naoto Shirahata

  Nanomaterials, 13 Nov. 2020, Peer-reviewed, Lead author, Corresponding author

  
• Recent Development to Explore the Use of Biodegradable Periodic Mesoporous Organosilica (BPMO) Nanomaterials for Cancer Therapy

  Shanmugavel Chinnathambi; Fuyuhiko Tamanoi

  Pharmaceutics, 18 Sep. 2020, Peer-reviewed, Lead author

  
• Recent advances on fluorescent biomarkers of near-infrared quantum dots for in vitro and in vivo imaging

  Shanmugavel Chinnathambi; Naoto Shirahata

  Science and Technology of Advanced Materials, 31 Dec. 2019, Peer-reviewed, Lead author

  
• Facile Formation of Stable Water‐Dispersed Luminescent Silicon Nanocrystals by Laser Processing in Liquid: Toward Fluorescent Labeling for Bio‐Imaging

  Ze Yuan; Toshihiro Nakamura; Shanmugavel Chinnathambi; Yanbai Pu; Naoto Shirahata; Kiyoto Matsuishi

  ChemNanoMat, Sep. 2019, Peer-reviewed

  
• Quercetin loaded PLGA microspheres induce apoptosis in breast cancer cells

  V. Karthick; Sucheta Panda; V. Ganesh Kumar; Dinesh Kumar; Lok Kumar Shrestha; Katsuhiko Ariga; K. Vasanth; Shanmugavel Chinnathambi; T. Stalin Dhas; K.S. Uma Suganya

  Applied Surface Science, Sep. 2019, Peer-reviewed

  
• Photostability of quantum dot micelles under ultraviolet irradiation

  Shanmugavel Chinnathambi; Nobutaka Hanagata

  Luminescence, Aug. 2019, Peer-reviewed, Lead author, Corresponding author

  
• Exploring the Binding Interaction Mechanism of Taxol in β-Tubulin and Bovine Serum Albumin: A Biophysical Approach

  Subramani Karthikeyan; Ganesan Bharanidharan; Sriram Ragavan; Saravanan Kandasamy; Shanmugavel Chinnathambi; Kanniyappan Udayakumar; Rajendiran Mangaiyarkarasi; Ramakrishnamurthy Suganya; Prakasarao Aruna; Singaravelu Ganesan

  Molecular Pharmaceutics, 04 Feb. 2019, Peer-reviewed

  
• Comparative Binding Analysis ofN-Acetylneuraminic Acid in Bovine Serum Albumin and Human α-1 Acid Glycoprotein

  Subramani Karthikeyan; Ganesan Bharanidharan; Sriram Ragavan; Saravanan Kandasamy; Shanmugavel Chinnathambi; Kanniyappan Udayakumar; Rajendiran Mangaiyarkarasi; Anandh Sundaramoorthy; Prakasarao Aruna; Singaravelu Ganesan

  Journal of Chemical Information and Modeling, 28 Jan. 2019, Peer-reviewed

  
• Molecular interaction of silicon quantum dot micelles with plasma proteins: hemoglobin and thrombin

  Shanmugavel Chinnathambi; Subramani Karthikeyan; Nobutaka Hanagata; Naoto Shirahata

  RSC Advances, 2019, Peer-reviewed, Lead author, Corresponding author

  
• 4-Hydroxycoumarin Derivative:N-(diphenylmethyl)-2-[(2-oxo-2H-chromen-4-yl)oxy]acetamide Interaction with Human Serum Albumin

  Shanmugavel Chinnathambi; Subramani Karthikeyan; Mangaiyarkarsi Rajendiran; Kanniyappan Udayakumar; Arunkumar Manoharan; Saravanan Kandasamy; Nobutaka Hanagata

  Journal of Spectroscopy, 16 Oct. 2018, Peer-reviewed, Lead author, Corresponding author

  
• Inverted Device Architecture for Enhanced Performance of Flexible Silicon Quantum Dot Light-Emitting Diode

  Batu Ghosh; Hiroyuki Yamada; Shanmugavel Chinnathambi; İrem Nur Gamze Özbilgin; Naoto Shirahata

  The Journal of Physical Chemistry Letters, 20 Sep. 2018, Peer-reviewed

  
• A cytotoxicity, optical spectroscopy and computational binding analysis of 4-[3-acetyl-5-(acetylamino)-2-methyl-2,3-dihydro-1,3,4-thiadiazole-2-yl]phenyl benzoate in calf thymus DNA

  Subramani Karthikeyan; Ganesan Bharanidharan; Rajendiran Mangaiyarkarasi; Shanmugavel Chinnathambi; Ragavan Sriram; Krishnaswamy Gunasekaran; Kandasamy Saravanan; Mani Gopikrishnan; Prakasarao Aruna; Singaravelu Ganesan

  Luminescence, Jun. 2018, Peer-reviewed

  
• Simplified detection of the hybridized DNA using a graphene field effect transistor

  Arun Kumar Manoharan; Shanmugavel Chinnathambi; Ramasamy Jayavel; Nobutaka Hanagata

  Science and Technology of Advanced Materials, 31 Dec. 2017, Peer-reviewed

  
• Synthesis, Cytotoxicity and Antitumor Activity of 4-[(1-(2-carbamothioylhydrazinylidene)ethyl]phenyl acetate (acesemi) Conjugated Chitosan Functionalized LaF3:Ce3+, Tb3+ Nanoparticles

  Rajendiran Mangaiyarkarasi; Shanmugavel Chinnathambi; Karthikeyan Subramani; Prakasarao Aruna; Singaravelu Ganesan

  Journal of Nanoscience and Nanotechnology, 01 Aug. 2017, Corresponding author

  
• Synthesis and fast transfer of monolayer MoS2 on reusable fused silica

  Tao Liang; Shuang Xie; Weifei Fu; Yu Cai; Chinnathambi Shanmugavel; Hideo Iwai; Daisuke Fujita; Nobutaka Hanagata; Hongzheng Chen; Mingsheng Xu

  Nanoscale, 2017, Peer-reviewed

  
• Biocompatible CdSe/ZnS quantum dot micelles for long-term cell imaging without alteration to the native structure of the blood plasma protein human serum albumin

  Shanmugavel Chinnathambi; Norhidayah Abu; Nobutaka Hanagata

  RSC Advances, 2017, Peer-reviewed, Lead author

  
• Paclitaxel conjugated Fe3O4@LaF3:Ce3+,Tb3+ nanoparticles as bifunctional targeting carriers for Cancer theranostics application

  Rajendiran Mangaiyarkarasi; Shanmugavel Chinnathambi; Subramani Karthikeyan; Prakasarao Aruna; Singaravelu Ganesan

  Journal of Magnetism and Magnetic Materials, Feb. 2016, Peer-reviewed

  
• Underlying the Mechanism of 5-Fluorouracil and Human Serum Albumin Interaction: A Biophysical Study

  Shanmugavel Chinnathambi; Subramani Karthikeyan, Manish Kesherwani, Devadasan Velmurugan and Nobutaka Hanagata

  Journal of Physical Chemistry & Biophysics, 2016, Peer-reviewed, Lead author

  
• Regulation of bifurcated cytokine induction by surface charge of nanoparticles during interaction between CpG oligodeoxynucleotides and toll-like receptor 9

  Shanmugavel Chinnathambi; Xiaodong Pi; Mingsheng Xu; Nobutaka Hanagata

  Journal of Drug Delivery Science and Technology, Oct. 2015, Peer-reviewed, Lead author

  
• Investigation of Optical Spectroscopic and Computational Binding Mode of Bovine Serum Albumin with 1, 4-Bis ((4-((4-Heptylpiperazin-1-yl) Methyl)-1H-1, 2, 3-Triazol-1-yl) Methyl) Benzene

  Subramani Karthikeyan; Shanmugavel Chinnathambi; Ayyavoo Kannan; Perumal Rajakumar; Devadasan Velmurugan; Ganesan Bharanidharan; Prakasarao Aruna; Singaravelu Ganesan

  Journal of Biochemical and Molecular Toxicology, Aug. 2015, Peer-reviewed

  
• Investigations on the Interactions of 5-Fluorouracil with Herring Sperm DNA: Steady State/Time Resolved and Molecular Modeling Studies

  Shanmugavel Chinnathambi; Subramani Karthikeyan; Devadasan Velmurugan; Nobutaka Hanagata; Prakasarao Aruna; Singaravelu Ganesan

  Biophysical Reviews and Letters, Jun. 2015, Peer-reviewed, Lead author

  
• Synthesis of 5-Fluorouracil conjugated LaF3:Tb3+/PEG-COOH nanoparticles and its studies on the interaction with bovine serum albumin: spectroscopic approach

  Rajendiran Mangaiyarkarasi; Shanmugavel Chinnathambi; Prakasarao Aruna; Singaravelu Ganesan

  Journal of Nanoparticle Research, Mar. 2015, Peer-reviewed

  
• Synthesis and formulation of methotrexate (MTX) conjugated LaF3:Tb3+/chitosan nanoparticles for targeted drug delivery applications

  Rajendiran Mangaiyarkarasi; Shanmugavel Chinnathambi; Prakasarao Aruna; Singaravelu Ganesan

  Biomedicine & Pharmacotherapy, Feb. 2015, Peer-reviewed

  
• Effect of Moderate UVC Irradiation on Bovine Serum Albumin and Complex with Antimetabolite 5-Fluorouracil: Fluorescence Spectroscopic and Molecular Modelling Studies

  Shanmugavel Chinnathambi; Subramani Karthikeyan; Devadasan Velmurugan; Nobutaka Hanagata; Prakasarao Aruna; Singaravelu Ganesan

  International Journal of Spectroscopy, 31 Jan. 2015, Peer-reviewed, Lead author

  
• Insights into the Binding of 3-(1-Phenylsulfonyl-2-methylindol-3-ylcarbonyl) Propanoic Acid to Bovine Serum Albumin: Spectroscopy and Molecular Modelling Studies

  Subramani Karthikeyan; Shanmugavel Chinnathambi; Devadasan Velmurugan; Ganesan Bharanidharan; Singaravelu Ganesan

  Nano Biomedicine and Engineering, 10 Jan. 2015, Peer-reviewed

  
• Synthesis and characterization of hafnium oxide nanoparticles for bio-safety

  Venkatachalam Jayaraman; Ganesan Bhavesh; Shanmugavel Chinnathambi; Singaravelu Ganesan; Prakasarao Aruna

  Materials Express, 01 Oct. 2014, Peer-reviewed

  
• Investigations on the interactions of 5-fluorouracil with bovine serum albumin: Optical spectroscopic and molecular modeling studies

  Shanmugavel Chinnathambi; Devadasan Velmurugan; Nobutaka Hanagata; Prakasa Rao Aruna; Singaravelu Ganesan

  Journal of Luminescence, Jul. 2014, Peer-reviewed, Lead author

  
• Silicon Quantum Dots for Biological Applications

  Shanmugavel Chinnathambi; Song Chen; Singaravelu Ganesan; Nobutaka Hanagata

  Advanced Healthcare Materials, Jan. 2014, Peer-reviewed, Lead author

  
• Large-Scale Fabrication of Free-Standing, Micropatterned Silica Nanotubes Via a Hybrid Hydrogel-Templated Route

  Song Chen; Xuetao Shi; Shanmugavel Chinnathambi; Nobutaka Hanagata

  Advanced Healthcare Materials, Aug. 2013, Peer-reviewed

  
• Synthesis of novel chitosan–silica/CpG oligodeoxynucleotide nanohybrids with enhanced delivery efficiency

  Song Chen; Huijie Zhang; Shanmugavel Chinnathambi; Nobutaka Hanagata

  Materials Science and Engineering: C, Aug. 2013, Peer-reviewed

  
• Generation of microgrooved silica nanotube membranes with sustained drug delivery and cell contact guidance ability by using a Teflon microfluidic chip

  Song Chen; Xuetao Shi; Shanmugavel Chinnathambi; Hongkai Wu; Nobutaka Hanagata

  Science and Technology of Advanced Materials, Mar. 2013, Peer-reviewed

  
• Binding Mode of CpG Oligodeoxynucleotides to Nanoparticles Regulates Bifurcated Cytokine induction via Toll-like Receptor 9

  Shanmugavel Chinnathambi; Song Chen; Singaravelu Ganesan; Nobutaka Hanagata

  Scientific Reports, Dec. 2012, Peer-reviewed, Lead author

  
• Effect of molecular weight of polyethyleneimine on loading of CpG oligodeoxynucleotides onto flake-shell silica nanoparticles for enhanced TLR9-mediated induction of interferon-α

  Manoharan; Qingmin Ji; Yamazaki; Shanmugavel Chinnathambi; Chen; Ganesan; Hill; Ariga:Nobutaka Hanagata

  International Journal of Nanomedicine, Jul. 2012, Peer-reviewed

  
• Fabrication of novel collagen-silica hybrid membranes with tailored biodegradation and strong cell contact guidance ability

  Song Chen; Shanmugavel Chinnathambi; Xuetao Shi; Akiyoshi Osaka; Yufang Zhu; Nobutaka Hanagata

  Journal of Materials Chemistry, 2012, Peer-reviewed

  

Presentations

• Silica / Silicon nanoparticles for biomedical applications

  Shanmugavel Chinnathambi

  Department of Physics, Meenakshi college of engineering, Chennai-78, India, 09 Jan. 2021, Invited

  
• Quantum dots for biomedical applications

  Shanmugavel Chinnathambi

  ICNAN 2019, VIT University, Vellore, India

  
• Quantum dots for biomedical applications

  Shanmugavel Chinnathambi

  Institute for Integrated Cell-Material Sciences, Kyoto University, Kyoto, Japan, 21 Nov. 2019

  
• Quantum dots for biomedical applications

  Shanmugavel Chinnathambi

  Centre for nanotechnology research, VIT University, Vellore, India, 14 Oct. 2019

  
• Biomedical applications of water-soluble quantum dots

  Shanmugavel Chinnathambi

  12th International Symposium on Nanomedicine (ISNM 2018), Yamaguchi University, Japan, Invited

  
• Semiconductor quantum dot for biomedical applications

  Shanmugavel Chinnathambi

  SIRIM-WAITRO International Conference (SWIC) 2018, Penang, Malaysia

  
• Silicon quantum dot micelles interaction with blood plasma proteins

  Shanmugavel Chinnathambi

  International Conference on Emerging Advanced Nanomaterials (ICEAN), Newcastle, Australia, Invited

  
• Quantum Dots for Biological Applications

  Shanmugavel Chinnathambi

  Sri Sarada Mahavidyalayam Arts and Science College for Women, India, 05 Jan. 2018, Invited

  
• Magnetic CdSe/ZnS Quantum Dot Micelles for In Vitro Cancer Cell Imaging

  Shanmugavel Chinnathambi

  Advanced Materials Conference, Langkawi, Malaysia

  
• Superparamagnetic CdSe/ZnS Quantum Dot Micelles for Cancer Cell Imaging

  Shanmugavel Chinnathambi

  10th Anniversary International Symposium on Nanomedicine (ISNM 2016), AIST, Tsukuba, Japan, Invited

  
• Functionalized Quantum Dots for Biological Applications

  Shanmugavel Chinnathambi

  Advanced Materials Research Center (AMREC), Kulim, Malaysia,, Invited

  
• Effect of interaction mode of CpG oligodeoxynucleotides with TLR9 on bifurcated cytokine induction

  Shanmugavel Chinnathambi

  The 6th Annual meeting of Nano-biomedical society, AIST, Tsukuba, Japan

  
• Synthesis and characterization of positively charged silicon quantum dots for delivery of nucleic acid drugs

  Shanmugavel Chinnathambi

  The 6th Annual meeting of Nano-biomedical society, AIST, Tsukuba, Japan, Invited

  

Books and Other Publications

• Delivery of anticancer drugs and Behavior analysis of the drugs by Using optical character of the Carriers

  Shanmugavel Chinnathambi, Single work

  Aug. 2014

  

Media Coverage

• The quest for perfect quantum dot biomarkers

  Asia Research News, Jan. 2020, Paper

  
• Biological imaging using near-infrared emission quantum dots

  Apr. 2019, Internet

  
• Binding Mode of CpG Oligodeoxynucleotides to Nanoparticles Regulates Bifurcated Cytokine induction via Toll-like Receptor 9

  Nature Asia, Jul. 2012, Internet

  
• Development of technology that enhances the efficacy of immunity-Activating nucleic acid drugs using nanoparticles –Application to treatment of allergic diseases and infectious diseases

  NIMS, Jun. 2012, Internet

  

External funds: Kakenhi

• Creation and biological evaluation of nanoparticle-based artificial transcription factor

  Grant-in-Aid for Early-Career Scientists

  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related

  Kyoto University

  CHINNATHAMBI Shanmugavel

  From 01 Apr. 2022, To 31 Mar. 2024, Granted

  NANO-TF;Silica nanoparticles;Mitochondrial factors

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K15249/