Basic Information

Faculty

• 薬学部

Academic Degree

• 修士（薬学）(岐阜薬科大学)
• 博士（薬学）(岐阜薬科大学)

Academic Resume (Graduate Schools)

• 岐阜薬科大学, 大学院薬学研究科博士課程分子生物学専攻, 修了
• 岐阜薬科大学, 大学院薬学研究科修士課程分子生物学専攻, 修了

Academic Resume (Undergraduate School/Majors)

• 岐阜薬科大学, 製造薬学科, 卒業

High School

• High School

  愛知県立岡崎北高校

ID,URL

• J-Global ID

  201401072248043023

researchmap URL

• https://researchmap.jp/7000008644

Research

Research Topics, Overview of the research

• Research Topics

  Biochemical and Chemical Biology Study of Mammalian Proteases

• Overview of the research

  We study of physiological and pathological roles for mammalian proteases via biochemical and chemical biological approaches.

Research Areas

• Life sciences, Cell biology

Papers

• Bisabosqual A: A novel asparagine synthetase inhibitor suppressing the proliferation and migration of human non-small cell lung cancer A549 cells.

  Yanjun Pan; Takehiro Suzuki; Kazuko Sakai; Yoshinori Hirano; Hiroaki Ikeda; Akira Hattori; Naoshi Dohmae; Kazuto Nishio; Hideaki Kakeya

  European journal of pharmacology, 05 Dec. 2023

  
• 「胎盤の形成と形成細胞及び妊娠成立のための免疫機構の新知見」 ヒト絨毛外栄養膜細胞による新規の免疫寛容誘導機構

  飯塚 崇; 鈴木 拓馬; 鏡 京介; 松本 多圭夫; 山崎 玲奈; 八十島 巌; 田中 有華; 大黒 多希子; 堀江 昭史; 小野 政徳; 服部 明; 藤原 浩

  日本生殖医学会雑誌, Oct. 2023

  
• Establishment of an MR1 Presentation Reporter Screening System and Identification of Phenylpropanoid Derivatives as MR1 Ligands.

  Takuro Matsuoka; Akira Hattori; Shinya Oishi; Mitsugu Araki; Biao Ma; Toshiki Fujii; Norihito Arichi; Yasushi Okuno; Hideaki Kakeya; Sho Yamasaki; Hiroaki Ohno; Shinsuke Inuki

  Journal of medicinal chemistry, 14 Sep. 2023

  
• Design, synthesis, and target identification of new hypoxia-inducible factor 1 (HIF-1) inhibitors containing 1-alkyl-1H-pyrazole-3-carboxamide moiety.

  Marina Sakai; Nobuaki Takahashi; Hiroaki Ikeda; Yutaka Furutani; Shoko Higuchi; Takehiro Suzuki; Naoshi Dohmae; Sayaka Kobayashi; Hiroshi Harada; Soichi Kojima; Tomokazu Matsuura; Akira Hattori; Hideaki Kakeya

  Bioorganic & medicinal chemistry, 15 Sep. 2021

  
• :Identification and Their Roles in the Processing of Antigen Peptides Presented to MHC Class I Molecules

  HATTORI Akira; TSUJIMOTO Masafumi

  KAGAKU TO SEIBUTSU, 2005

  
• 小胞体アミノペプチダーゼの小胞体貯留メカニズム

  服部 明; 谷岡 利裕; 辻本 雅文

  日本薬学会年会要旨集, Mar. 2004

  
• Laeverin/aminopeptidase Q induces indoleamine 2,3-dioxygenase-1 in human monocytes.

  Takuma Suzuki; Takashi Iizuka; Kyosuke Kagami; Takeo Matsumoto; Rena Yamazaki; Takiko Daikoku; Akihito Horie; Masanori Ono; Akira Hattori; Hiroshi Fujiwara

  iScience, 15 Sep. 2023

  
• Spheroid formation induces chemokine production in trophoblast-derived Swan71 cells.

  Tatsuhito Kanda; Kyosuke Kagami; Takashi Iizuka; Haruki Kasama; Takeo Matsumoto; Yuya Sakai; Takuma Suzuki; Megumi Yamamoto; Ayumi Matsuoka; Rena Yamazaki; Akira Hattori; Akihito Horie; Takiko Daikoku; Masanori Ono; Hiroshi Fujiwara

  American journal of reproductive immunology (New York, N.Y. : 1989), Aug. 2023

  
• ChemInform Abstract: Structure Elucidation of Verucopeptin, a HIF-1 Inhibitory Polyketide-Hexapeptide Hybrid Metabolite from an Actinomycete.

  Aya Yoshimura; Shinichi Nishimura; Saori Otsuka; Akira Hattori; Hideaki Kakeya

  ChemInform, 03 Mar. 2016

  
• ChemInform Abstract: Tumescenamide C, an Antimicrobial Cyclic Lipodepsipeptide from Streptomyces sp.

  Shinji Kishimoto; Yuta Tsunematsu; Shinichi Nishimura; Yutaka Hayashi; Akira Hattori; Hideaki Kakeya

  ChemInform, Oct. 2012

  
• The effects of 5‐OP‐RU stereochemistry on its stability and MAIT‐MR1 axis

  Takuro Matsuoka; Chihiro Motozono; Akira Hattori; Hideaki Kakeya; Sho Yamasaki; Shinya Oishi; Hiroaki Ohno; Shinsuke Inuki

  ChemBioChem, 16 Nov. 2020

  
• Reciprocal Expression Patterns of Placental Leucine Aminopeptidase/Insulin-Regulated Aminopeptidase and Vasopressin in the Murine Brain

  Yoshikuni Goto; Takahiro J. Nakamura; Kenji Ogawa; Akira Hattori; Masafumi Tsujimoto

  Frontiers in Molecular Biosciences, 24 Jul. 2020, Peer-reviewed

  
• Promoting Roles of Embryonic Signals in Embryo Implantation and Placentation in Cooperation with Endocrine and Immune Systems.

  Hiroshi Fujiwara; Masanori Ono; Yukiyasu Sato; Kazuhiko Imakawa; Takashi Iizuka; Kyosuke Kagami; Tomoko Fujiwara; Akihito Horie; Hirohiko Tani; Akira Hattori; Takiko Daikoku; Yoshihiko Araki

  International journal of molecular sciences, 10 Mar. 2020, Peer-reviewed

  
• Ubiquitin carboxyl-terminal hydrolase L1 promotes hypoxia-inducible factor 1-dependent tumor cell malignancy in spheroid models.

  Li X; Hattori A; Takahashi S; Goto Y; Harada H; Kakeya H

  Cancer science, Nov. 2019, Peer-reviewed

  
• Isolation, Structure Elucidation, and Conformational Regulation of Myropeptins, Lipopeptides from the Fungus Myrothecium roridum.

  Yoshimura A; Nishimura S; Suzuki T; Hattori A; Dohmae N; Kato T; Kakeya H

  Organic letters, Sep. 2019, Peer-reviewed

  
• Acute-phase protein-like properties of endoplasmic reticulum aminopeptidase 1.

  Yoshikuni Goto; Takahiro J Nakamura; Kenji Ogawa; Akira Hattori; Masafumi Tsujimoto

  Journal of biochemistry, 01 Feb. 2019, Peer-reviewed

  
• Factors Regulating Human Extravillous Trophoblast Invasion: Chemokine-peptidase and CD9-integrin Systems.

  Hiroshi Fujiwara; Hisanori Matsumoto; Yukiyasu Sato; Akihito Horie; Masanori Ono; Mitsuhiro Nakamura; Yasunari Mizumoto; Kyosuke Kagami; Tomoko Fujiwara; Akira Hattori; Yoshiko Maida; Takiko Daikoku; Kazuhiko Imakawa; Yoshihiko Araki

  Current pharmaceutical biotechnology, 2018, Peer-reviewed

  
• CD9 suppresses human extravillous trophoblast invasion

  Hisanori Matsumoto; Yukiyasu Sato; Akihito Horie; Koh Suginami; Hirohiko Tani; Akira Hattori; Yoshihiko Araki; Kyosuke Kagami; Ikuo Konishi; Hiroshi Fujiwara

  PLACENTA, Nov. 2016

  
• Expression, purification and enzymatic characterization of a recombinant human ubiquitin-specific protease 47

  Jinhua Piao; Aika Tashiro; Minako Nishikawa; Yutaka Aoki; Eiko Moriyoshi; Akira Hattori; Hideaki Kakeyay

  JOURNAL OF BIOCHEMISTRY, Dec. 2015, Peer-reviewed

  
• Involvement of Phenylalanine 297 in the Construction of the Substrate Pocket of Human Aminopeptidase B

  Atsushi Ohnishi; Jobu Watanabe; Yuko Ogawa; Yoshikuni Goto; Akira Hattori; Masafumi Tsujimoto

  BIOCHEMISTRY, Oct. 2015

  
• Substrate-dependent nitric oxide synthesis by secreted endoplasmic reticulum aminopeptidase 1 in macrophages

  Yoshikuni Goto; Kenji Ogawa; Takahiro J. Nakamura; Akira Hattori; Masafumi Tsujimoto

  JOURNAL OF BIOCHEMISTRY, Jun. 2015, Peer-reviewed

  
• Design, synthesis, and structure-activity relationships of 1-ethylpyrazole-3-carboxamide compounds as novel hypoxia-inducible factor (HIF)-1 inhibitors

  Yorinobu Yasuda; Takeaki Arakawa; Yumi Nawata; Sayaka Shimada; Shinya Oishi; Nobutaka Fujii; Shinichi Nishimura; Akira Hattori; Hideaki Kakeya

  BIOORGANIC & MEDICINAL CHEMISTRY, Apr. 2015, Peer-reviewed

  
• Isolation, Structure Elucidation, and Total Synthesis of Tryptopeptins A and B, New TGF-beta Signaling Modulators from Streptomyces sp.

  Yuta Tsunematsu; Shinichi Nishimura; Akira Hattori; Shinya Oishi; Nobutaka Fujii; Hideaki Kakeya

  ORGANIC LETTERS, Jan. 2015, Peer-reviewed

  
• Chlorocatechelins A and B from Streptomyces sp.: New Siderophores Containing Chlorinated Catecholate Groups and an Acylguanidine Structure

  Shinji Kishimoto; Shinichi Nishimura; Akira Hattori; Masafumi Tsujimoto; Masaki Hatano; Masayuki Igarashi; Hideaki Kakeya

  ORGANIC LETTERS, Dec. 2014, Peer-reviewed

  
• Prediction and Determination of the Stereochemistry of the 1,3,5-Trimethyl-Substituted Alkyl Chain in Verucopeptin, a Microbial Metabolite

  Aya Yoshimura; Shinji Kishimoto; Shinichi Nishimura; Saori Otsuka; Yuki Sakai; Akira Hattori; Hideaki Kakeya

  JOURNAL OF ORGANIC CHEMISTRY, Aug. 2014, Peer-reviewed

  
• Role of glutamine-169 in the substrate recognition of human aminopeptidase B

  Yuko Ogawa; Atsushi Ohnishi; Yoshikuni Goto; Yoshiki Sakuma; Jobu Watanabe; Akira Hattori; Masafumi Tsujimoto

  BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, Jun. 2014

  
• Role of glutamine-169 in the substrate recognition of human aminopeptidase B.

  Ogawa Y; Ohnishi A; Goto Y; Sakuma Y; Watanabe J; Hattori A; Tsujimoto M

  Biochimica et biophysica acta, Jun. 2014, Peer-reviewed

  
• TLR-Mediated Secretion of Endoplasmic Reticulum Aminopeptidase 1 from Macrophages

  Yoshikuni Goto; Kenji Ogawa; Takahiro J. Nakamura; Akira Hattori; Masafumi Tsujimoto

  JOURNAL OF IMMUNOLOGY, May 2014, Peer-reviewed

  
• Structure and Biological Activity of 8-Deoxyheronamide C from a Marine-Derived Streptomyces sp.: Heronamides Target Saturated Hydrocarbon Chains in Lipid Membranes

  Ryosuke Sugiyama; Shinichi Nishimura; Nobuaki Matsumori; Yuta Tsunematsu; Akira Hattori; Hideaki Kakeya

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Apr. 2014, Peer-reviewed

  
• New insights into the role of aminopeptidases in the treatment for both preeclampsia and preterm labor

  Shigehiko Mizutani; Taihei Tsunemi; Eita Mizutani; Akira Hattori; Masafumi Tsujimoto; Hiroshi Kobayashi

  EXPERT OPINION ON INVESTIGATIONAL DRUGS, Nov. 2013, Peer-reviewed

  
• Association of epigenetic alterations in the human C7orf24 gene with the aberrant gene expression in malignant cells

  Yuji Ohno; Akira Hattori; Tatsuhiro Yoshiki; Hideaki Kakeya

  JOURNAL OF BIOCHEMISTRY, Oct. 2013, Peer-reviewed

  
• Endoplasmic reticulum aminopeptidases: Biochemistry, physiology and pathology

  Akira Hattori; Masafumi Tsujimoto

  Journal of Biochemistry, Sep. 2013, Peer-reviewed

  
• PH-sensitive DNA cleaving agents: In situ activation by ring contraction of benzo-fused cyclobutanols

  Yuuki Nagamoto; Akira Hattori; Hideaki Kakeya; Yoshiji Takemoto; Kiyosei Takasu

  Chemical Communications, 04 Apr. 2013, Peer-reviewed

  
• Chemical tagging of a drug target using 5-sulfonyl tetrazole

  Satsuki Otsuki; Shinichi Nishimura; Hisae Takabatake; Kozue Nakajima; Yasuaki Takasu; Toru Yagura; Yuki Sakai; Akira Hattori; Hideaki Kakeya

  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Mar. 2013, Peer-reviewed

  
• 分泌型小胞体アミノペプチダーゼ1によるArg産生を介したマクロファージのNO産生亢進

  後藤芳邦; 小川健司; 中村孝博; 服部明; 辻本雅文

  日本病態プロテアーゼ学会学術集会プログラム抄録集, 2013

  
• Aminopeptidase Q/Laeverin

  Akira Hattori; Masato Maruyama; Hiroshi Fujiwara; Masafumi Tsujimoto

  Handbook of Proteolytic Enzymes, 2013, Peer-reviewed

  
• Tumescenamide C, an antimicrobial cyclic lipodepsipeptide from Streptomyces sp.

  Shinji Kishimoto; Yuta Tsunematsu; Shinichi Nishimura; Yutaka Hayashi; Akira Hattori; Hideaki Kakeya

  TETRAHEDRON, Jul. 2012, Peer-reviewed

  
• Laeverin/aminopeptidase Q induces trophoblast invasion during human early placentation

  Akihito Horie; Hiroshi Fujiwara; Yukiyasu Sato; Koh Suginami; Hisanori Matsumoto; Masato Maruyama; Ikuo Konishi; Akira Hattori

  HUMAN REPRODUCTION, May 2012, Peer-reviewed

  
• Exon 10 Coding Sequence Is Important for Endoplasmic Reticulum Retention of Endoplasmic Reticulum Aminopeptidase 1

  Akira Hattori; Yoshikuni Goto; Masafumi Tsujimoto

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Apr. 2012, Peer-reviewed

  
• [C7orf24/gamma-glutamyl cyclotransferase as a molecular target for cancer chemotherapy].

  Y. Ohno; A. Hattori; H. Kakeya

  Nihon rinsho. Japanese journal of clinical medicine, 2012, Peer-reviewed

  
• Multiple NF-Y-binding CCAAT boxes are essential for transcriptional regulation of the human C7orf24 gene, a novel tumor-associated gene

  Yuji Ohno; Akira Hattori; Masamichi Ueda; Susumu Kageyama; Tatsuhiro Yoshiki; Hideaki Kakeya

  FEBS JOURNAL, Nov. 2011, Peer-reviewed

  
• Role of the arabidopsis leucine aminopeptidase 2

  Rungaroon Waditee-Sirisattha; Akira Hattori; Junko Shibato; Randeep Rakwal; Sophon Sirisattha; Teruhiro Takabe; Masafumi Tsujimoto

  Plant Signaling and Behavior, Oct. 2011, Peer-reviewed

  
• P-43 Pentadepsin A, a Novel Lipodepsipeptide Produced by Streptomyces sp.(Poster Presentation)

  Kishimoto Shinji; Tsunematsu Yuta; Nishimura Shinichi; Hattori Akira; Kakeya Hideaki

  Symposium on the Chemistry of Natural Products, symposium papers, 02 Sep. 2011

  
• Secretion of Endoplasmic Reticulum Aminopeptidase 1 Is Involved in the Activation of Macrophages Induced by Lipopolysaccharide and Interferon-gamma

  Yoshikuni Goto; Kenji Ogawa; Akira Hattori; Masafumi Tsujimoto

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 2011, Peer-reviewed

  
• Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides

  Efthalia Zervoudi; Athanasios Papakyriakou; Dimitra Georgiadou; Irini Evnouchidou; Anna Gajda; Marcin Poreba; Guy S. Salvesen; Marcin Drag; Akira Hattor; Luc Swevers; Dionisios Vourloumis; Efstratios Stratikos

  BIOCHEMICAL JOURNAL, Apr. 2011, Peer-reviewed

  
• Cutting Edge: Coding Single Nucleotide Polymorphisms of Endoplasmic Reticulum Aminopeptidase 1 Can Affect Antigenic Peptide Generation In Vitro by Influencing Basic Enzymatic Properties of the Enzyme

  Irini Evnouchidou; Ram P. Kamal; Sergey S. Seregin; Yoshikuni Goto; Masafumi Tsujimoto; Akira Hattori; Paraskevi V. Voulgari; Alexandros A. Drosos; Andrea Amalfitano; Ian A. York; Efstratios Stratikos

  JOURNAL OF IMMUNOLOGY, Feb. 2011, Peer-reviewed

  
• The Arabidopsis aminopeptidase LAP2 regulates plant growth, leaf longevity and stress response

  Rungaroon Waditee-Sirisattha; Junko Shibato; Randeep Rakwal; Sophon Sirisattha; Akira Hattori; Takeshi Nakano; Teruhiro Takabe; Masafumi Tsujimoto

  NEW PHYTOLOGIST, 2011, Peer-reviewed

  
• Involvement of Glutamine-238 in the Substrate Specificity of Human Laeverin/Aminopeptidase Q

  Yoshikuni Goto; Rina Yoshioka; Naomi Arisaka; Akira Hattori; Masafumi Tsujimoto

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Jan. 2011, Peer-reviewed

  
• Histidine 379 of Human Laeverin/Aminopeptidase Q, a Nonconserved Residue within the Exopeptidase Motif, Defines Its Distinctive Enzymatic Properties

  Masato Maruyama; Naomi Arisaka; Yoshikuni Goto; Yosuke Ohsawa; Hideshi Inoue; Hiroshi Fujiwara; Akira Hattori; Masafumi Tsujimoto

  JOURNAL OF BIOLOGICAL CHEMISTRY, Dec. 2009, Peer-reviewed

  
• Physiological and pathophysiological roles of placental aminopeptidase in maternal sera: Possible relation to preeclampsia and preterm delivery

  Shigehiko Mizutani; Katsuhiko Naruse; Akira Hattori; Masafumi Tsujimoto; Hiroshi Kobayashi

  Expert Opinion on Medical Diagnostics, Sep. 2009, Peer-reviewed

  
• The effect of recombinant aminopeptidase A (APA) on hypertension in pregnant spontaneously hypertensive rats (SHRs)

  Masakazu Ishii; Akira Hattori; Yasushi Numaguchi; Xiuyang Ma; Tetsuro Nagasaka; Masafumi Tsujimoto; Toyoaki Murohara; Hiroshi Kobayashi; Sigehiko Mizutani

  EARLY HUMAN DEVELOPMENT, Sep. 2009, Peer-reviewed

  
• Oxytocin hypersensitivity in pregnant P-LAP deficient mice

  Masakazu Ishii; Katsuhiko Naruse; Akira Hattori; Masafumi Tsujimoto; Shoichi Ishiura; Yasushi Numaguchi; Toyoaki Murohara; Hiroshi Kobayashi; Shigehiko Mizutani

  LIFE SCIENCES, May 2009, Peer-reviewed

  
• The Effect of Recombinant Anninopeptidase A on Hypertension in Spontaneously Hypertensive Rats: Its Effect in Comparison with Candesartan

  M. Ishii; A. Hattori; Y. Numaguchi; M. Tsujimoto; S. Ishiura; H. Kobayashi; T. Murohara; J. -W. Wright; S. Mizutani

  HORMONE AND METABOLIC RESEARCH, Dec. 2008, Peer-reviewed

  
• Glutamine-181 is crucial in the enzymatic activity and substrate specificity of human endoplasmic-reticulum aminopeptidase-1

  Yoshikuni Goto; Hiroe Tanji; Akira Hattori; Masafumi Tsujimoto

  BIOCHEMICAL JOURNAL, Nov. 2008, Peer-reviewed

  
• New insights into the importance of aminopeptidase A in hypertension

  Shigehiko Mizutani; Masakazu Ishii; Akira Hattori; Seiji Nomura; Yasushi Numaguchi; Masafumi Tsujimoto; Hiroshi Kobayshi; Toyoaki Murohara; John W. Wright

  HEART FAILURE REVIEWS, Sep. 2008, Peer-reviewed

  
• Biochemical and enzymatic properties of the M1 family of aminopeptidases involved in the regulation of blood pressure

  Masafumi Tsujimoto; Yoshikuni Goto; Masato Maruyama; Akira Hattori

  HEART FAILURE REVIEWS, Sep. 2008, Peer-reviewed

  
• Asparatic acid 221 is critical in the calcium-induced modulation of the enzymatic activity of human aminopeptidase A

  Yoshikuni Goto; Akira Hattori; Shigehiko Mizutani; Masafumi Tsujimoto

  JOURNAL OF BIOLOGICAL CHEMISTRY, Dec. 2007, Peer-reviewed

  
• Laeverin/aminopeptidase Q, a novel bestatin-sensitive leucine aminopeptidase belonging to the M1 family of aminopeptidases

  Masato Maruyama; Akira Hattori; Yoshikuni Goto; Masamichi Ueda; Michiyuki Maeda; Hiroshi Fujiwara; Masafumi Tsujimoto

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jul. 2007, Peer-reviewed

  
• Essential role of placental leucine aminopeptidase in gynecologic malignancy

  Shigehiko Mizutani; Kiyosumi Shibata; Fumitaka Kikkawa; Akira Hattori; Masafumi Tsujimoto; Masakazu Ishii; Hiroshi Kobayashi

  EXPERT OPINION ON THERAPEUTIC TARGETS, Apr. 2007, Peer-reviewed

  
• Enzymatic properties of human aminopeptidase A - Regulation of its enzymatic activity by calcium and angiotensin IV

  Yoshikuni Goto; Akira Hattori; Yasuhiro Ishii; Shigehiko Mizutani; Masafumi Tsujimoto

  JOURNAL OF BIOLOGICAL CHEMISTRY, Aug. 2006, Peer-reviewed

  
• Expression of endoplasmic reticulum aminopeptidases in EBV-B cell lines from healthy donors and in leukemia/lymphoma, carcinoma, and melanoma cell lines

  D Fruci; S Ferracuti; MZ Limongi; Cunsolo, V; E Giorda; R Fraioli; L Sibilio; O Carroll; K Hattori; PM van Endert; P Giacomini

  JOURNAL OF IMMUNOLOGY, Apr. 2006, Peer-reviewed

  
• Endoplasmic reticulum aminopeptidase-1 mediates leukemia inhibitory factor-induced cell surface human leukocyte antigen-G expression in JEG-3 choriocarcinoma cells

  F Shido; T Ito; S Nomura; E Yamamoto; S Sumigama; K Ino; A Itakura; A Hattori; M Tsujimoto; S Mizutani; F Kikkawa

  ENDOCRINOLOGY, Apr. 2006, Peer-reviewed

  
• Reduced activity of the hypertension-associated Lys528Arg mutant of human adipocyte-derived leucine aminopeptidase (A-LAP)/ER-aminopeptidase-1

  Y Goto; A Hattori; Y Ishii; M Tsujimoto

  FEBS LETTERS, Mar. 2006, Peer-reviewed

  
• Physiological roles of M1 aminopeptidase family

  HATTORI Akira; TSUJIMOTO Masafumi

  Blood & Vessel, 01 Feb. 2006

  
• The oxytocinase subfamily of M1 aminopeptidases

  M Tsujimoto; A Hattori

  BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, Aug. 2005, Peer-reviewed

  
• Regulation of the human leukocyte-derived arginine aminopeptidase/endoplasmic reticulum-aminopeptidase 2 gene by interferon-gamma

  T Tanioka; A Hattori; S Mizutani; M Tsujimoto

  FEBS JOURNAL, Feb. 2005, Peer-reviewed

  
• Distribution of adipocyte-derived leucine aminopeptidase (A-LAP)/ER-aminopeptidase (ERAP)-1 in human uterine endometrium

  D Shibata; H Ando; A Iwase; T Nagasaka; A Hattori; M Tsujimoto; S Mizutani

  JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, Sep. 2004, Peer-reviewed

  
• Processing of antigenic peptides by aminopeptidases

  A Hattori; M Tsujimoto

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Jun. 2004, Peer-reviewed

  
• Adipocyte-derived leucine aminopeptidase suppresses angiogenesis in human endometrial carcinoma via renin-angiotensin system

  Y Watanabe; K Shibata; F Kikkawa; H Kajiyama; K Ino; A Hattori; M Tsujimoto; S Mizutani

  CLINICAL CANCER RESEARCH, Dec. 2003, Peer-reviewed

  
• Expression of placental leucine aminopeptidase and adipocyte-derived leucine aminopeptidase in human normal and malignant invasive trophoblastic cells

  K Ino; F Kikkawa; T Suzuki; H Kajiyama; K Shibata; S Nomura; A Itakura; M Ito; T Nagasaka; A Hattori; M Tsujimoto; S Mizutani

  LABORATORY INVESTIGATION, Dec. 2003, Peer-reviewed

  
• Expression of adipocyte-derived leucine aminopeptidase in endometrial cancer - Association with tumor grade and CA-125

  H Kazeto; S Nomura; N Ito; T Ito; Y Watanabe; H Kajiyama; K Shibata; K Ino; K Tamakoshi; A Hattori; F Kikkawa; T Nagasaka; M Tsujimoto; S Mizutania

  TUMOR BIOLOGY, Dec. 2003, Peer-reviewed

  
• Structural changes in the glycosaminoglycan chain of rat skin decorin with growth

  Y Nomura; Y Abe; Y Ishii; M Watanabe; M Kobayashi; A Hattori; M Tsujimoto

  JOURNAL OF DERMATOLOGY, Sep. 2003, Peer-reviewed

  
• Human leukocyte-derived arginine aminopeptidase - The third member of the oxytocinase subfamily of aminopeptidases

  T Tanioka; A Hattori; S Masuda; Y Nomura; H Nakayama; S Mizutani; M Tsujimoto

  JOURNAL OF BIOLOGICAL CHEMISTRY, Aug. 2003, Peer-reviewed

  
• Involvement of the V-2 receptor in vasopressin-stimulated translocation of placental leucine aminopeptidase/oxytocinase in renal cells

  S Masuda; A Hattori; H Matsumoto; S Miyazawa; Y Natori; S Mizutani; M Tsujimoto

  EUROPEAN JOURNAL OF BIOCHEMISTRY, May 2003, Peer-reviewed

  
• An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides

  T Saric; SC Chang; A Hattori; IA York; S Markant; KL Rock; M Tsujimoto; AL Goldberg

  NATURE IMMUNOLOGY, Dec. 2002, Peer-reviewed

  
• Expression of placental leucine aminopeptidase/oxytocinase in neuronal cells and its action on neuronal peptides

  H Matsumoto; T Nagasaka; A Hattori; T Rogi; N Tsuruoka; S Mizutani; M Tsujimoto

  EUROPEAN JOURNAL OF BIOCHEMISTRY, Jun. 2001, Peer-reviewed

  
• Biochemical characterization of placental leucine aminopeptidase/oxytocinase and its related enzyme, adipocyte-derived leucine aminopeptidase

  M Tsujimoto; H Matsumoto; A Hattori

  CELL-SURFACE AMINOPEPTIDASES: BASIC AND CLINICAL ASPECTS, 2001, Peer-reviewed

  
• Cleavage of peptide hormones by placental leucine aminopeptidase/oxytocinase

  H Matsumoto; A Hattori; S Mizutani; M Tsujimoto

  CELL-SURFACE AMINOPEPTIDASES: BASIC AND CLINICAL ASPECTS, 2001, Peer-reviewed

  
• Molecular cloning and characterization of adipocyte-derived leucine aminopeptidase

  A Hattori; H Matsumoto; S Mizutani; M Tsujimoto

  CELL-SURFACE AMINOPEPTIDASES: BASIC AND CLINICAL ASPECTS, 2001, Peer-reviewed

  
• Genomic organization of the human adipocyte-derived leucine aminopeptidase gene and its relationship to the placental leucine aminopeptidase/oxytocinase gene

  Akira Hattori; Ken Matsumoto; Shigehiko Mizutani; Masafumi Tsujimoto

  Journal of Biochemistry, 2001

  
• Immunoaffinity purification and characterization of native placental leucine aminopeptidase/oxytocinase from human placenta

  Y Nakanishi; S Nomura; M Okada; T Ito; Y Katsumata; F Kikkawa; A Hattori; M Tsujimoto; S Mizutani

  PLACENTA, Sep. 2000, Peer-reviewed

  
• Characterization of recombinant human adipocyte-derived leucine aminopeptidase expressed in Chinese hamster ovary cells

  Akira Hattori; Kenji Kitatani; Hideko Matsumoto; Shinobu Miyazawa; Tomohiro Rogi; Nobuo Tsuruoka; Shigehiko Mizutani; Yasuhiro Natori; Masafumi Tsujimoto

  Journal of Biochemistry, 2000

  
• Characterization of a recombinant soluble form of human placental leucine aminopeptidase/oxytocinase expressed in Chinese hamster ovary cells

  H Matsumoto; T Rogi; K Yamashiro; S Kodama; N Tsuruoka; A Hattori; K Takio; S Mizutani; M Tsujimoto

  EUROPEAN JOURNAL OF BIOCHEMISTRY, Jan. 2000, Peer-reviewed

  
• Bone morphogenetic protein-2 promotes survival and differentiation of striatal GABAergic neurons in the absence of glial cell proliferation

  A Hattori; M Katayama; S Iwasaki; K Ishii; M Tsujimoto; M Kohno

  JOURNAL OF NEUROCHEMISTRY, Jun. 1999, Peer-reviewed

  
• Molecular cloning of adipocyte-derived leucine aminopeptidase highly related to placental leucine aminopeptidase oxytocinase

  A Hattori; H Matsumoto; S Mizutani; M Tsujimoto

  JOURNAL OF BIOCHEMISTRY, May 1999, Peer-reviewed

  
• Characterization of the bone morphogenetic protein-2 as a neurotrophic factor - Induction of neuronal differentiation of PC12 cells in the absence of mitogen-activated protein kinase activation.

  S Iwasaki; A Hattori; M Sato; M Tsujimoto; M Kohno

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jul. 1996, Peer-reviewed

  
• Bone morphogenetic protein-2 is markedly synergistic with tumor necrosis factor in stimulating the production of nerve growth factor in fibroblasts

  A Hattori; M Tsujimoto; K Hayashi; M Kohno

  BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL, May 1996, Peer-reviewed

  
• Tumor necrosis factor (TNF) stimulates the production of nerve growth factor in fibroblasts via the 55-kDa type 1 TNF receptor

  A Hattori; K Hayashi; M Kohno

  FEBS LETTERS, Jan. 1996, Peer-reviewed

  
• Cell type-specific modulation of cell growth by transforming growth factor beta 1 does not correlate with mitogen-activated protein kinase activation

  Y Chatani; S Tanimura; N Miyoshi; A Hattori; M Sato; M Kohno

  JOURNAL OF BIOLOGICAL CHEMISTRY, Dec. 1995, Peer-reviewed

  
• DISTRIBUTION AND CHARACTERIZATION OF SPECIFIC CELLULAR-BINDING PROTEINS FOR BONE MORPHOGENETIC PROTEIN-2

  S IWASAKI; N TSURUOKA; A HATTORI; M SATO; M TSUJIMOTO; M KOHNO

  JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 1995, Peer-reviewed

  
• STIMULATION OF NERVE GROWTH-FACTOR SYNTHESIS SECRETION IN MOUSE ASTROGLIAL CELLS BY COENZYMES

  K MURASE; A HATTORI; M KOHNO; K HAYASHI

  BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL, Jul. 1993, Peer-reviewed

  
• TUMOR-NECROSIS-FACTOR STIMULATES THE SYNTHESIS AND SECRETION OF BIOLOGICALLY-ACTIVE NERVE GROWTH-FACTOR IN NONNEURONAL CELLS

  A HATTORI; E TANAKA; K MURASE; N ISHIDA; Y CHATANI; M TSUJIMOTO; K HAYASHI; M KOHNO

  JOURNAL OF BIOLOGICAL CHEMISTRY, Feb. 1993, Peer-reviewed

  
• Stimulation of nerve growth factor synthesis/secretion in mouse astroglial cells by coenzymes

  K. Murase; A. Hattori; M. Kohno; K. Hayashi

  Biochemistry and Molecular Biology International, 1993, Peer-reviewed

  
• MITOGEN-INDUCED TYROSINE PHOSPHORYLATION OF 41 KDA AND 43 KDA PROTEINS - POTENTIAL ROLE IN INTEGRATING MULTIPLE MITOGENIC SIGNALING PATHWAYS

  M KOHNO; Y CHATANI; E TANAKA; A HATTORI; N NISHIZAWA

  BIOCHEMICAL JOURNAL, Nov. 1992, Peer-reviewed

  
• HEPATOCYTE GROWTH-FACTOR RAPIDLY INDUCES THE TYROSINE PHOSPHORYLATION OF 41-KDA AND 43-KDA PROTEINS IN MOUSE KERATINOCYTES

  Y CHATANI; A ITOH; E TANAKA; A HATTORI; T NAKAMURA; M KOHNO

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jun. 1992, Peer-reviewed

  
• MITOGEN-INDUCED TYROSINE-PHOSPHORYLATED 41-KDA AND 43-KDA PROTEINS ARE FAMILY MEMBERS OF EXTRACELLULAR SIGNAL-REGULATED KINASES/MICROTUBULE-ASSOCIATED PROTEIN-2 KINASES

  Y CHATANI; E TANAKA; K TOBE; A HATTORI; M SATO; H TAMEMOTO; N NISHIZAWA; H NOMOTO; T TAKEYA; T KADOWAKI; M KASUGA; M KOHNO

  JOURNAL OF BIOLOGICAL CHEMISTRY, May 1992, Peer-reviewed

  

Misc.

• Swan71細胞株はスフェロイド培養でケモカインの発現が上昇する

  神田龍人; 鏡京介; 飯塚崇; 笠間春輝; 坂井友哉; 鈴木拓馬; 松岡歩; 山崎玲奈; 服部明; 堀江昭史; 大黒多希子; 小野政徳; 藤原浩

  日本生殖医学会雑誌, 2025

  
• 小胞体アミノペプチダーゼ1の機能低下は,不安障害様症状を惹起する

  後藤芳邦; 中村孝博; 杉山瑞輝; 服部明; 小川健司; 辻本雅文

  日本分子生物学会年会プログラム・要旨集(Web), 2024

  
• Dysfuction of ER-aminopeptidase 1 induce serotonin-dependent anxiety

  平井杏奈; 鈴木優香; 中村孝博; 小川健司; 服部明; 辻本雅文; 後藤芳邦

  日本分子生物学会年会プログラム・要旨集(Web), 2022

  
• Swan71細胞株はスフェロイド培養でケモカインの発現が上昇する

  神田龍人; 鏡京介; 飯塚崇; 笠間春輝; 松本多圭夫; 坂井友哉; 鈴木拓馬; 山本惠; 松岡歩; 山崎玲奈; 服部明; 堀江昭史; 大黒多希子; 小野政徳; 藤原浩

  日本絨毛性疾患研究会・日本胎盤学会学術集会プログラム・抄録集, 2023

  
• Total Synthesis of Cryptopleurine Derivatives and their Activity Evaluation

  山岡庸介; 山川拓朗; 服部明; 瀧川紘; 高須清誠

  日本薬学会年会要旨集(CD-ROM), 2020

  
• P1-32-2 新規アミノペプチダーゼ,laeverinの初期絨毛内における発現と機能(Group66 生殖生理・病理・基礎2,一般演題,第63回日本産科婦人科学会学術講演会)

  堀江 昭史; 佐藤 幸保; 杉並 興; 松本 久宣; 藤原 浩; 小西 郁生; 服部 明

  日本産科婦人科學會雜誌, 2011

  
• 白血球由来アルギニンアミノペプチダーゼの転写調節機構の解析

  谷岡 利裕; 服部 明; 辻本 雅文

  日本薬学会年会要旨集, Mar. 2004

  
• Bone Morphogenetic Protein-2 Is Markedly Synergistic with Tumor Necrosis Factor in Stimulating the Production of Nerve Growth Factor in Fibroblasts.

  HATTORI AKIRA; TSUJIMOTO MASAFUMI; HAYASHI KYOZO; KOHNO MICHIAKI

  The annual proceedings of Gifu College of Pharmacy, 30 Jun. 1997

  
• Characterization of the Bone Morphogenetic Protein-2 as a Neurotrophic Factor.

  IWASAKI SHOJI; HATTORI AKIRA; SATO MASAHIRO; TSUJIMOTO MASAFUMI; KOHNO MICHIAKI

  The annual proceedings of Gifu College of Pharmacy, 30 Jun. 1997

  
• Distribution and Characterization of Specific Cellular Binding Proteins for Bone Morphogenetic Protein-2.

  IWASAKI SHOJI; TSURUOKA NOBUO; HATTORI AKIRA; SATO MASAHIRO; TSUJIMOTO MASAFUMI; KOHNO MICHIAKI

  The annual proceedings of Gifu College of Pharmacy, 30 Jun. 1996

  
• Cell Type-specific Modulation of Cell Growth by Transforming Growth Factor β1 Does Not Correlate with Mitogen-activated Protein Kinase Activation.

  CHATANI YUJI; TANIMURA SUSUMU; MIYOSHI NAOMI; HATTORI AKIRA; SATO MASAHIRO; KOHNO MICHIAKI

  The annual proceedings of Gifu College of Pharmacy, 30 Jun. 1996

  
• Tumor Necrosis Factor Is Markedly Synergistic with Interleukin 1 and Interferon-γ in Stimulating The Production of Nerve Growth Factor in Fibroblasts.

  HATTORI AKIRA; IWASAKI SHOJI; MURASE KATSUHITO; TSUJIMOT MASAFUMI; SATO MASAHIRO; HAYASHI KYOZO; KOHNO MICHIAKI

  The annual proceedings of Gifu College of Pharmacy, 30 Jun. 1995

  
• Stimulation of Nerve Growth Factor Synthesis/Secretion in Mouse Astroglical Cells by Coenzymes.

  MURASE KATSUHITO; HATTORI AKIRA; KOHNO MICHIAKI; HAYASHI KYOZO

  The annual proceedings of Gifu College of Pharmacy, 30 Jun. 1994

  
• Tomor Necrosis Factor Stimulates the Synthesis and Secretion of Biologically Active Nerve Growth Factor in Non-neuronal Cells.

  HATTORI AKIRA; TANAKA EIKO; MURASE KATSUHITO; ISHIDA NOBUHIRO; CHATANI YUJI; TSUJIMOTO MASAFUMI; HAYASHI KYOZO; KOHNO MICHIAKI

  The annual proceedings of Gifu College of Pharmacy, 30 Jun. 1994

  
• Mitogen-induced tyrosine phosphorylation of 41 kDa and 43 kDa proteins.

  KOHNO MICHIAKI; CHATANI YUJI; TANAKA EIKO; HATTORI AKIRA; NISHIZAWA NAOMI

  The annual proceedings of Gifu College of Pharmacy, 30 Jun. 1993

  
• Hepatocyte Growth Factor Rapidly Induces the Tyrosine Phosphorylation of 41-kDa and 43-kDa Proteins in Mouse Keratinocytes.

  CHATANI YUJI; ITOH AKIO; TANAKA EIKO; HATTORI AKIRA; NAKAMURA TOSHIKAZU; KOHNO MICHIAKI

  The annual proceedings of Gifu College of Pharmacy, 30 Jun. 1993

  
• A New Familial Defect of Platelet Release Mechanism (the Intracellular Ca++ Transport Defect?)

  HATTORI A.

  Acta Haematologica Japonica, Jul. 1981

  
• 1,3-Dimethyl鎖状構造の立体配置決定法の検証:tumescenamide Cとverucopeptinを例に

  吉村彩; 西村慎一; 岸本真治; 服部明; 掛谷秀昭

  日本薬学会年会要旨集(CD-ROM), 2013

  
• 微生物メタボローム解析により見出した新規環状リポデプシペプチド

  岸本真治; 恒松雄太; 西村慎一; 服部明; 掛谷秀昭

  日本薬学会年会要旨集, 2011

  
• MAIT細胞の活性化を担うMR1リガンドの構造活性相関研究

  松岡巧朗; 本園千尋; 本園千尋; 服部明; 掛谷秀昭; 山崎晶; 山崎晶; 大石真也; 大野浩章; 井貫晋輔

  創薬懇話会講演要旨集, 2022

  
• Identification of a novel MR1 ligand by screening with split-luciferase and its structure-activity relationship study

  松岡巧朗; 服部明; 大石真也; 有地法人; 掛谷秀昭; 山崎晶; 山崎晶; 大野浩章; 井貫晋輔

  メディシナルケミストリーシンポジウム講演要旨集, 2022

  
• 合成ピリミジン化合物MS-206はTNFの繊維芽細胞に対するNGF産生促進作用を増強する.

  服部 明; 山口 裕之; 栗屋 昭; 河野 通明

  日本分子生物学会年会プログラム・講演要旨集, Aug. 1996

  
• Total Synthesis of Cryptopleurine Derivatives and their Bioactivity Evaluation

  山岡庸介; 立石海斗; 山川拓朗; 服部明; 瀧川紘; 掛谷秀昭; 高須清誠

  日本薬学会年会要旨集(Web), 2021

  
• 新規ポリエンマクロラクタム8-deoxyheronamide Cの単離・構造決定とその生物活性

  杉山龍介; 西村慎一; 恒松雄太; 服部明; 掛谷秀昭

  日本薬学会年会要旨集(CD-ROM), 2013

  
• 海洋由来放線菌が産生するheronamide類の単離と生物活性

  杉山龍介; 西村慎一; 松森信明; 恒松雄太; 服部明; 村田道雄; 掛谷秀昭

  天然有機化合物討論会講演要旨集(Web), 2013

  
• Functional correlation between USP47 and catenin D1 in cancer malignancy

  遠藤健太; 服部明; LI Xue-Bing; 小川裕樹; PAN Chengqian; 掛谷秀昭

  日本薬学会年会要旨集(CD-ROM), 2020

  
• 小胞体アミノペプチダーゼ1遺伝子欠損はセロトニン合成亢進を介して不安障害を惹起する

  小林春奈; 後藤芳邦; 中村孝博; 小川健司; 服部明; 辻本雅文

  日本薬学会年会要旨集(CD-ROM), 2019

  
• 小胞体アミノペプチダーゼ1遺伝子欠損は,セロトニン合成を亢進することで不安を誘発する

  斎藤朱里; 後藤芳邦; 中村孝博; 小川健司; 服部明; 辻本雅文

  日本生化学会大会(Web), 2019

  
• 低酸素誘導因子(HIF-1)阻害化合物verucopeptinの生合成遺伝子クラスター同定と新規類縁体の探索

  金子賢介; 長尾野映花; 服部明; 掛谷秀昭

  日本分析化学会有機微量分析研究懇談会・計測自動制御学会力学量計測部会合同シンポジウム講演要旨集, 2019

  
• Involvement of UCHL1 in the HIF1-dependent tumor cell malignancy in 3D cell culture model

  李雪氷; 服部明; 後藤容子; 原田浩; 掛谷秀昭

  日本癌学会学術総会抄録集(Web), 2019

  
• TGF-βシグナル伝達阻害剤KUSC-Y244はTGF-βによる上皮間葉転換を抑制する

  杉崎俊文; 高須康明; 服部明; 小嶋聡一; 掛谷秀昭

  日本薬学会年会要旨集(CD-ROM), 2018

  
• Saccharothriolide Bは腎細胞癌においてプロテアソーム経路非依存的にHIF-2αを分解する

  高橋千絵; 盧山; 蒋雨露; 東克暁; 西村慎一; 服部明; 掛谷秀昭

  日本生化学会大会(Web), 2018

  
• Calpain7の細胞内局在の解析

  松原拓真; 服部明; 掛谷秀昭

  日本生化学会大会(Web), 2018

  
• 酵素反応速度論的解析を用いた脱ユビキチン化酵素USP47のC末端領域の機能解析

  福岡啓太; 服部明; 掛谷秀昭

  日本生化学会大会(Web), 2018

  
• ERAP1結合型エキソソームによるマクロファージの古典的活性化

  後藤芳邦; 小川裕子; 津元裕樹; 三浦ゆり; 中村孝博; 小川健司; 服部明; 秋元義弘; 川上速人; 遠藤玉夫; 矢ノ下良平; 辻本雅文

  日本生化学会大会(Web), 2017

  
• UCHL1-HIF-1活性化経路を標的とした分子標的抗がん剤開発研究

  LI Xuebing; 服部明; 後藤容子; 森鳰章代; 平岡眞寛; 原田浩; 原田浩; 原田浩; 掛谷秀昭

  日本薬学会年会要旨集(CD-ROM), 2017

  
• 脱ユビキチン化酵素USP47のC末端ホモロジー領域はそのポリユビキチン鎖認識機構に重要である

  福岡啓太; 服部明; 掛谷秀昭

  日本生化学会大会(Web), 2017

  
• 小胞体アミノペプチダーゼはエンドトキシンショック時に惹起される一酸化窒素合成を亢進する

  後藤芳邦; 小川健司; 中村孝博; 服部明; 辻本雅文

  日本生化学会大会(Web), 2016

  
• 脱ユビキチン化酵素USP47のポリユビキチン鎖消化に関わる分子内領域の同定

  福岡啓太; 青木豊; 服部明; 掛谷秀昭

  日本生化学会大会(Web), 2016

  
• 脱ユビキチン化酵素阻害によるHIF-1発現レベルの制御

  吹上遼介; 小林万祐子; 服部明; 掛谷秀昭

  日本生化学会大会(Web), 2016

  
• Structure Elucidation of Verucopeptin, a HIF-1 Inhibitory Polyketide-Hexapeptide Hybrid Metabolite from an Actinomycete

  Aya Yoshimura; Shinichi Nishimura; Saori Otsuka; Akira Hattori; Hideaki Kakeya

  ORGANIC LETTERS, Nov. 2015

  
• 細菌感染に伴い血中に分泌されたERAP1は血中アミノ酸や一酸化窒素濃度を調節する

  後藤芳邦; 小川健司; 中村孝博; 青嶋瑞樹; 荒俣晃貴; 高田慧; 町田綾乃; 吉野僚太; 服部明; 辻本雅文

  日本生化学会大会(Web), 2015

  
• 小胞体アミノペプチダーゼ1遺伝子欠損に伴うマクロファージのFcγ受容体依存性貪食活性の低下

  後藤芳邦; 小川健司; 中村孝博; 服部明; 辻本雅文

  日本生化学会大会(Web), 2014

  
• 脱Urm1化活性の検出および分子同定

  小林万祐子; 服部明; 青木豊; 掛谷秀昭

  日本薬学会年会要旨集(CD-ROM), 2014

  
• 脱ユビキチン化酵素USP47の活性発現におけるC末端領域の役割

  青木豊; 朴錦花; 小林万祐子; 服部明; 掛谷秀昭

  日本病態プロテアーゼ学会学術集会プログラム抄録集, 2014

  
• アシルグアニジン構造を有する新規シデロフォアchlorocatechelin類の単離・構造決定,全合成,および生物活性

  岸本真治; 西村慎一; 服部明; 波多野和樹; 五十嵐雅之; 掛谷秀昭

  天然有機化合物討論会講演要旨集(Web), 2014

  
• 新規低酸素誘導因子HIF阻害剤の探索と構造活性相関研究

  YASUDA YORINOBU; NAWATA YUMI; ARAKAWA TAKEAKI; SHIMADA SAYAKA; HATTORI AKIRA; NISHIMURA SHIN'ICHI; OISHI SHIN'YA; FUJII NOBUTAKA; KAKEYA HIDEAKI

  日本薬学会年会要旨集(CD-ROM), 2014

  
• マクロファージ古典的活性化に重要なトール様受容体を介した小胞体アミノペプチダーゼの分泌

  後藤芳邦; 小川健司; 中村孝博; 服部明; 辻本雅文

  日本生化学会大会(Web), 2013

  
• Development of Tricyclic Cyclobutanols as a pH-dependent DNA Alkylating Agent

  Yuuki Nagamoto; Akira Hattori; Kiyosei Takasu; Yoshiji Takemoto

  7th Seoul-Kyoto-Osaka Joint Symposium, May 2012, Peer-reviewed

  
• 新規TGF‐βシグナル伝達阻害剤tryptopeptin Aおよび分子プローブの合成研究

  KASAI SHOTA; SAKAI YUKI; TSUNEMATSU YUTA; HATTORI AKIRA; OISHI SHIN'YA; FUJII NOBUTAKA; NISHIMURA SHIN'ICHI; KAKEYA HIDEAKI

  日本薬学会年会要旨集, 05 Mar. 2012

  
• 小胞体アミノペプチダーゼの分泌を介したマクロファージのNO産生亢進

  後藤芳邦; 小川健司; 服部明; 辻本雅文

  日本生化学会大会(Web), 2012

  
• がん分子標的としてのC7orf24/γ-グルタミルシクロトランスフェラーゼ

  大野裕司; 服部明; 掛谷秀昭

  日本臨床, 2012

  
• 低酸素誘導因子(HIF)活性化経路を阻害するverucopeptinの化学的解析研究

  吉村彩; 大塚紗織; 西村慎一; 服部明; 長田裕之; 掛谷秀昭

  天然有機化合物討論会講演要旨集(Web), 2012

  
• Leverin, a specific cell-surface marker for human extravirous trophoblast, regulates their migration

  A. Horie; H. Fujiwara; Y. Sato; K. Suginami; H. Matsumoto; M. Maruyama; I. Konishi; A. Hattori

  HUMAN REPRODUCTION, 2012

  
• 含水条件での連続反応を利用したpH依存型新規DNAアルキル化剤の設計

  永本祐樹; 服部 明; 掛谷秀昭; 竹本佳司; 高須清誠

  第9回次世代を担う有機化学シンポジウム, May 2011, Peer-reviewed

  
• 放線菌の生産する新規抗がんリード化合物tryptopeptin Aの化学構造決定

  TSUNEMATSU YUTA; HATTORI AKIRA; OISHI SHIN'YA; FUJII NOBUTAKA; NISHIMURA SHIN'ICHI; KAKEYA HIDEAKI

  日本薬学会年会要旨集, 05 Mar. 2011

  
• 小胞体アミノペプチダーゼ1の分泌機構

  後藤芳邦; 小川健司; 服部明; 辻本雅文

  生化学, 2011

  
• グランザイムBをレポーターに用いた脱ユビキチン化酵素測定法の構築

  服部明; PIAO Jinhua; 田代亜衣香; 森吉英子; 掛谷秀昭

  生化学, 2011

  
• ヒトC7orf24遺伝子の発現は転写開始点近傍の3ケ所のCCAAT配列によって正に制御される

  大野裕司; 服部明; 上田正道; 影山進; 吉貴達寛; 掛谷秀昭

  生化学, 2011

  
• 放線菌が生産する新規TGF‐βシグナル伝達阻害剤tryptopeptin Aの単離・構造解析と合成

  TSUNEMATSU YUTA; OISHI SHIN'YA; FUJII NOBUTAKA; NISHIMURA SHIN'ICHI; HATTORI AKIRA; KAKEYA HIDEAKI

  天然有機化合物討論会講演要旨集, 01 Sep. 2010

  
• ヒトC7orf24/GGCT遺伝子の転写はNF-Yにより活性化される

  大野裕司; 服部明; 上田正道; 影山進; 吉貴達寛; 掛谷秀昭

  生化学, 2010

  
• 脱ユビキチン化酵素USP47の酵素学的性状解析

  TASHIRO AIKA; HATTORI AKIRA; PIAO JINHUA; YAMADA AI; OISHI SHIN'YA; FUJII NOBUTAKA; KAKEYA HIDEAKI

  生化学, 2010

  
• HIF‐1機能制御化合物の評価系構築と探索研究

  HATTORI AKIRA; TSUNEMATSU YUTA; OTSUKA SAORI; TAKASU YASUAKI; NISHIMURA SHIN'ICHI; YAKURA TOORU; OISHI SHIN'YA; FUJII NOBUTAKA; SHIMIZU SHIRO; OSADA HIROYUKI; KAKEYA HIDEAKI

  日本薬学会年会要旨集, 05 Mar. 2009

  
• 小胞体アミノペプチダーゼの基質認識機構

  後藤芳邦; 服部明; 辻本雅文

  日本薬学会年会要旨集, 2009

  
• マクロファージにおけるカルシウムを介した小胞体アミノペプチダーゼ-1の分泌

  後藤芳邦; 服部明; 辻本雅文

  生化学, 2009

  
• M1アミノペプチダーゼファミリーの生理的/病理学的機能

  服部明; 服部明; 丸山正人; 後藤芳邦; 辻本雅文

  ケミカルバイオロジーシンポジウム発表要旨集 第4回 化学-生物融合領域創成の軌跡 理研シンポジウム 平成20年, 2008

  
• ヒト脂肪細胞由来ロイシンアミノペプチダーゼのGln-181残基は基質特異性に重要である

  後藤芳邦; 丹治弘江; 服部明; 辻本雅文

  生化学, 2008

  
• CaイオンによるアミノペプチダーゼA活性制御機構の解明

  後藤芳邦; 服部明; 服部明; 辻本雅文

  日本薬学会年会要旨集, 2008

  
• アミノペプチダーゼAのAsp-221残基はCa²⁺によるアミノペプチダーゼ活性の調節に必須である

  後藤芳邦; 服部明; 辻本雅文

  ケミカルバイオロジーシンポジウム発表要旨集 第4回 化学-生物融合領域創成の軌跡 理研シンポジウム 平成20年, 2008

  
• アミノペプチダーゼAのCaイオンによる活性制御メカニズム

  服部明; 後藤芳邦; 辻本雅文

  日本薬学会年会要旨集, 2007

  
• ヒトアミノペプチダーゼAのAsp²²¹残基はCa²⁺による活性制御に必須である

  後藤芳邦; 服部明; 服部明; 辻本雅文

  生化学, 2007

  
• Anti-hypertensive effect of recombinant aminopeptidase a (AP-A) in spontaneously hypertensive rats (SHRS)

  Masakazu Ishii; Akira Hattori; Chinatsu Hattori; Yasushi Numaguchi; Masafumi Tsujimoto; Shoichi Ishiura; Hiroshi Kobayashi; Toyoaki Murohara; Shigehiko Mizutani

  JOURNAL OF HYPERTENSION, Dec. 2006

  
• 本態性高血圧症と相関が認められるcSNP型変異体K528R A-LAPの酵素活性

  後藤芳邦; 服部明; 辻本雅文

  日本薬学会年会要旨集, 2006

  
• Identification and characterization of aminopeptidases belonging to the oxytocinase subfamily

  A Hattori; M Tsujimoto

  SEIKAGAKU, Sep. 2003

  
• Bone morphogenetic protein-2 promotes survival and differentiation of striatal gabaergic neurons in the absence of glial cell proliferation

  A Hattori; S Iwasaki; M Tsujimoto; M Kohno

  BONE, Apr. 1999

  
• Application of NGF/PC12 cell system for screening tubulin inhibitors

  M. Kohno; A. Hattori; H. Yamaguchi

  Japanese Journal of Cancer and Chemotherapy, 22 Sep. 1997

  
• TUMOR-NECROSIS-FACTOR IS MARKEDLY SYNERGISTIC WITH INTERLEUKIN-1 AND INTERFERON-GAMMA IN STIMULATING THE PRODUCTION OF NERVE GROWTH-FACTOR IN FIBROBLASTS

  A HATTORI; S IWASAKI; K MURASE; M TSUJIMOTO; M SATO; K HAYASHI; M KOHNO

  FEBS LETTERS, Mar. 1994

  

Presentations

• TGF-βシグナル伝達阻害剤KUSC-Y244はTGF-βによる上皮間葉転換を抑制する

  杉崎俊文; 高須康明; 服部 明; 小嶋聡一; 掛谷秀昭

  27 Mar. 2018

  
• 脱ユビキチン化酵素阻害によるHIF-1発現レベルの制御.

  吹上遼介; 小林万祐子; 服部 明; 掛谷秀昭

  27 Sep. 2016

  
• 脱ユビキチン化酵素USP47のポリユビキチン鎖消化に関わる分子内領域の同定

  福岡啓太; 青木 豊; 服部 明; 掛谷秀昭

  第89回日本生化学会大会, 27 Sep. 2016

  
• 脱ユビキチン化酵素(USP)47の分子内ドメインの機能解析

  青木 豊; 朴 錦花; 小林 万祐子; 服部 明; 掛谷 秀昭

  日本薬学会134年会, 2014

  
• 脱Urm1化活性の検出および分子同定

  小林万祐子; 服部 明; 青木 豊; 掛谷秀昭

  日本薬学会134年会, 2014

  
• 脱ユビキチン化酵素USP47の活性発現におけるC末端領域の役割

  青木豊; 朴錦花; 小林万祐子; 服部明; 掛谷秀昭

  第19回日本病態プロテアーゼ学会学術集会, 2014

  
• 脱ユビキチン化酵素(USP)47の活性発現機構の解析

  朴錦花; 服部明; 青木豊; 小林万祐子; 森吉英子; 掛谷秀昭

  日本薬学会第133年会, 2013

  
• ヒトUSP47の脱ユビキチン化酵素活性の解析

  朴錦花; 田代亜衣香; 西川未来子; 森吉英子; 服部明; 掛谷秀昭

  2012

  
• 脱ユビキチン化酵素UCH-L3は酸化ストレス下で不活性化され

  西川未来子; 小林万祐子; 朴錦花; 森吉英子; 服部明; 掛谷秀昭

  日本薬学会第132年会, 2012

  
• Activity-based Profillingによる酸化ストレス感受性脱ユビキチン化酵素の同定

  服部明; 西川未来子; 朴錦花; 小林万祐子; 森吉英子; 掛谷秀昭

  日本ケミカルバイオロジー学会 第7回年会, 2012

  
• 脱ユビキチン化酵素UCH-L3は酸化ストレスの標的タンパク質である

  服部明; 西川未来子; 朴錦花; 小林万祐子; 森吉英子; 掛谷秀昭

  第85回日本生化学会, 2012

  
• 脱ユビキチン化酵素(USP)47の活性発現における分子内ユビキチン様ドメインの役割

  朴錦花; 服部明; 青木豊; 小林万祐子; 森吉英子; 掛谷秀昭

  第85回日本生化学会, 2012

  
• 脱ユビキチン化酵素活性の新しい測定法の確立

  服部明; 田代亜衣香; 森吉英子; 朴錦花; 掛谷秀昭

  日本薬学会第131年会, 2011

  
• グランザイムBをレポーターに用いた脱ユビキチン化酵素活性測定法の構築

  服部明; 朴錦花; 田代亜衣香; 森吉英子; 掛谷秀昭

  第84回日本生化学会, 2011

  
• ヒトC7orf24の遺伝子発現は、転写開始点近傍の3ヶ所のCCAAT配列に制御される

  大野裕司; 服部明; 上田正道; 影山進; 吉貴達寛; 掛谷秀昭

  第84回日本生化学会, 2011

  
• C7orf24/GGCTの転写はNF-Yにより活性化される

  大野裕司; 服部明; 上田正道; 影山進; 吉貴達寛; 掛谷秀昭

  83回日本生化学会大会・第33回日本分子生物学会年会合同大会:, 2010

  
• ヒト脱ユビキチン化酵素USP47の酵素学的性状解析

  田代亜衣香; 服部明; 朴錦花; 山田愛; 大石真也; 藤井信孝; 掛谷秀昭

  83回日本生化学会大会・第33回日本分子生物学会年会合同大会:, 2010

  
• HIF-1機能制御化合物の評価系構築と探索研究

  服部明; 恒松雄太; 大塚紗織; 高須康明; 西村慎一; 矢倉徹; 大石真也; 藤井信孝; 清水史郎; 長田裕之; 掛谷秀昭

  日本薬学会第129年会, 2009

  
• 新規癌関連因子ヒトC7orf24の転写制御機構の解析

  大野裕司; 服部明; 掛谷秀昭

  第13回日本癌分子標的治療学会, 2009

  

Industrial Property Rights

• 特許第6270547号, 特開2015-166329, 特願2014-041703, 新規生物活性物質

  掛谷 秀昭; 西村 慎一; 服部 明; 岸本 真治; 波多野 和樹; 五十嵐 雅之

  
• 特開2015-166329, 特願2014-041703, 新規生物活性物質

  掛谷 秀昭; 西村 慎一; 服部 明; 岸本 真治; 波多野 和樹; 五十嵐 雅之

  
• 特開2014-097954, 特願2012-250490, 3β−ヒドロキシステロイドデヒドロゲナーゼ阻害剤

  掛谷 秀昭; 酒井 佑宜; 服部 明; 西村 慎一; 岡村 均; 土居 雅夫

  
• WO2011-102436, JP2011053428, TGF−βシグナル伝達阻害剤

  掛谷 秀昭; 服部 明; 高須 康明; 藤井 信孝; 大石 真也; 小嶋 聡一; 原 詳子

  

External funds: Kakenhi

• The effects of novel embryonic signal, laeverin, on stem cells and immune system and its clinical application

  Grant-in-Aid for Scientific Research (A)

  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields

  Kanazawa University

  Hiroshi Fujiwara

  From 05 Apr. 2021, To 31 Mar. 2025, Project Closed

  胚シグナル;laeverin;免疫寛容;幹細胞;癌転移

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H04837/
• Identification and analysis of a new group of diseases with a common etiology of abnormal immune response to embryonic signals

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields

  Kanazawa University

  Hiroshi Fujiwara

  From 28 Jun. 2019, To 31 Mar. 2021, Project Closed

  胚シグナル;免疫寛容;幹細胞;laeverin;免疫応答異常;自己免疫疾患

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K22681/
• Design, Synthesis and Evaluation of Biologically Active Molecules Based on Ring Strain

  Grant-in-Aid for Scientific Research (B)

  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related

  Kyoto University

  Kiyosei Takasu

  From 01 Apr. 2019, To 31 Mar. 2022, Project Closed

  ひずみ分子;精密有機合成;小員環;中員環;ADC;刺激応答;ひずみ化合物;C-C結合開裂;酸化;多環芳香族化合物;イノラート;シクロブテン;炭素四員環;生理活性物質;刺激応答型分子;分子ひずみ;面性不斉

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H03350/
• Identification and analysis of circulating embryonic stem cells derived from human chorionic stroma at early stage

  Grant-in-Aid for Challenging Research (Exploratory)

  Kanazawa University

  Hiroshi Fujiwara

  From 30 Jun. 2017, To 31 Mar. 2019, Project Closed

  絨毛由来幹細胞;laeverin;循環幹細胞;Laeverin;胎児循環幹細胞;絨毛間質;臍帯血;遺伝子改変マウス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K19719/
• Promoting mechnisms of embryonic signals in embryo implantation induced by the immune system

  Grant-in-Aid for Scientific Research (B)

  Kanazawa University

  Fujiwara Hiroshi

  From 01 Apr. 2017, To 31 Mar. 2020, Project Closed

  HCG;laeverin;胚シグナル;着床不全;透明帯の糖鎖構造

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H04337/
• Analysis of chorionic villi-derived embryo stem cells by novel sten cell markers, laeberin and hTERT

  Grant-in-Aid for Challenging Exploratory Research

  Kanazawa University

  Fujiwara Hiroshi

  From 01 Apr. 2016, To 31 Mar. 2017, Project Closed

  laeverin;臍帯血;初期絨毛;hTERT;Oct4;テロメラーゼ活性;胎児循環幹細胞;ヒト絨毛

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K15702/
• Identification of non-canonical degradation pathway of HIF-1 alpha promoted by de-ubiqutinating enzyme inhibitor.

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Akira Hattori

  From 01 Apr. 2016, To 31 Mar. 2019, Project Closed

  ユビキチン;脱ユビキチン化酵素活性;低酸素誘導因子;プロテアソーム;タンパク質分解;低酸素応答;HIF-1;脱ユビキチン化酵素;p38MAPキナーゼ;anisomycin

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K07114/
• Stereocontrolled synthesis of poly-substituted medium-sized cyclic compounds by electrocyclic ring opening reaction and the synthesis of biologically active molecules

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Kiyosei Takasu

  From 01 Apr. 2016, To 31 Mar. 2019, Project Closed

  分子ひずみ;中員環化合物;小員環化合物;医薬候補化合物;有機材料;反応開発;シクロブタン;シクロブテン;キラリティ;生理活性天然物;中員環;面性不斉;シクロプロパン;シクロブタノン;ヘリセン;新規反応;小員環;電子環状反応;不斉合成;生物活性分子

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H05073/
• Role of ERAP1 in the pathogenesis of mental disorders

  Grant-in-Aid for Challenging Exploratory Research

  Teikyo Heisei University

  MASAFUMI TSUJIMOTO

  From 01 Apr. 2015, To 31 Mar. 2017, Project Closed

  小胞体アミノペプチダーゼ;ノックアウトマウス;セロトニン;遺伝子欠損マウス;ERAP1;ERAP1-/-マウス;尾懸垂試験;強制水泳試験;高架式十字迷路試験

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K15088/
• Identification of embryo-derived implantation-inducing factors (embryonic signals) and their clinical application

  Grant-in-Aid for Scientific Research (B)

  Kanazawa University

  Fujiwara Hiroshi

  From 01 Apr. 2014, To 31 Mar. 2017, Project Closed

  胚シグナル;透明帯;HCG;Laeverin;免疫寛容;着床;laeverin

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26293358/
• Pathophysiological roles of M1 aminopeptidases

  Grant-in-Aid for Scientific Research (B)

  Teikyo Heisei University

  Masafumi TSUJIMOTO

  From 01 Apr. 2013, To 31 Mar. 2016, Project Closed

  M1アミノペプチダーゼ;小胞体アミノペプチダーゼ;ノックアウトマウス;一酸化窒素;ERAP1;アルギニン;Toll-様受容体;MyD88;カルモジュリン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25293083/
• Discovery of new reactions and utilities of 4-membered carbocyles based on their unique ring strains.

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  KIYOSEI TAKASU

  From 01 Apr. 2013, To 31 Mar. 2016, Project Closed

  有機合成;分子ひずみ;シクロブタン;中員環;天然物合成;機能性分子;反応開発;シクロブテン;生物活性天然物;不斉合成;四員環炭化水素;小員環;合成化学;触媒反応

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25293002/
• Induction of immune-tolerance by a novel human trophoblast-specific soluble factor, laeverin

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Hiroshi FUJIWARA

  From 01 Apr. 2012, To 31 Mar. 2013, Project Closed

  ヒト絨毛外栄養膜細胞;laeverin;免疫寛容;胚シグナル

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24659730/
• Role of aminopeptidases in atherosclerosis

  Grant-in-Aid for Challenging Exploratory Research

  Teikyo Heisei University

  Masafumi TSUJIMOTO

  From 01 Apr. 2012, To 31 Mar. 2015, Project Closed

  小胞体アミノペプチダーゼ;マクロファージ;インターフェロン;LPS;高血圧症;一酸化窒素;NO産生

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24659153/
• Mechanism of unanchored polyubiquitin chain production

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Akira HATTORI

  From 01 Apr. 2012, To 31 Mar. 2014, Project Closed

  ユビキチン;脱ユビキチン化酵素;activity-based probe;プローブ;システインプロテアーゼ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24659099/
• Analysis of maternal recognition through embryo-specific sugar antigen and its inducing mechanisms for embryo implantation and placentation

  Grant-in-Aid for Scientific Research (B)

  Kanazawa University;Kyoto University

  Hiroshi FUJIWARA

  From 01 Apr. 2011, To 31 Mar. 2014, Project Closed

  糖鎖抗原;胚認識;胚着床;胎盤形成;免疫細胞;樹状細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390389/
• Biochemical and physiological studies on deubiquitinating enzymes based on an analysis of the enzymatic activity dynamics

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Akira HATTORI

  From 01 Apr. 2011, To 31 Mar. 2014, Project Closed

  ユビキチン;脱ユビキチン化酵素;activity-based probe;活性制御;酸化ストレス;プローブ;ユビキチン様ドメイン;プロテアーゼ;アクティビティーベースドプローブ;プロテオミクス解析;activety-based probe

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23310160/
• 抗原トリミングアミノペプチダーゼの作用発現メカニズムと制御

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Kyoto University

  服部 明

  From 01 Apr. 2011, To 31 Mar. 2013, Project Closed

  アミノペプチダーゼ;小胞体アミノペプチダーゼ;抗原ペプチド;強直性脊椎炎;一塩基多型;HLA;マクロファージ;小胞体貯留

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-23133504/
• 免疫系による発生初期胚の認識機構-透明帯を利用した哺乳類の着床誘導戦略の証明-

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  藤原 浩

  From 01 Apr. 2010, To 31 Mar. 2011, Project Closed

  透明帯;胚シグナル;着床;免疫細胞;EPF

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22659299/
• Biological Function of the M1 Family of Human Aminopeptidases

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Akira HATTORI

  From 01 Apr. 2008, To 31 Mar. 2011, Project Closed

  アミノペプチダーゼ;M1ファミリー;抗原提示;阻害剤;部位特異的変異導入法;基質特異性;小胞体アミノペプチダーゼ;Laeverin;プロテアーゼ;遺伝子発現調節

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590057/
• Analysis of tissue remodeling mechanisms by circulating blood cells during human reproduction

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Hiroshi FUJIWARA

  From 01 Apr. 2008, To 31 Mar. 2011, Project Closed

  組織再構築;黄体形成;胎盤形成;胚着床;妊娠;末梢血単核球;血小板;子宮内膜;絨毛外栄養膜細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390434/
• 小胞体におけるMHCクラスI提示抗原のN末端トリミング過程の分子メカニズム解析

  Grant-in-Aid for Young Scientists (B)

  Kyoto University;The Institute of Physical and Chemical Research

  服部 明

  From 01 Apr. 2006, To 31 Mar. 2008, Project Closed

  小胞体アミノペプチダーゼ;脂肪細胞由来ロイシンアミノペプチダーゼ;MHCクラスI抗原ペプチド;インターフェロンーγ;部位特異的変異導入法;活性発現メカニズム;小胞体アミノペプチターゼ;脂肪細胞由来ロイシンアミノペプチターゼ;白血球由来アルギニンアミノペプチターゼ;小胞体貯留機構;X線結晶構造解析

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18790077/
• Mechanisms of Enzymatic Action of the Oxytocinase Subfamily of Aminopeptidases

  Grant-in-Aid for Scientific Research (B)

  The Institute of Physical and Chemical Research

  Masafumi TSUJIMOTO

  From 01 Apr. 2006, To 31 Mar. 2009, Project Closed

  アミノペプチダーゼ;基質特異性;一塩基多型;オキシトシナーゼサブファミリー;脂肪細胞由来ロイシンアミノペプチダーゼ;白血球由来アルギニンアミノペプチダーゼ;リーベリン;アミノペプチダーゼA;白血球由来アルギニンアミノペップチダーゼ;胎盤性ロイシンアミノペプチダーゼ;立体構造解析;アンギオテンシンIV

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18390031/
• 抗原ペプチドプロセシングにおける小胞体アミノペプチダーゼの作用メカニズムの解明

  Grant-in-Aid for Young Scientists (B)

  The Institute of Physical and Chemical Research

  服部 明

  From 01 Apr. 2004, To 31 Mar. 2006, Project Closed

  小胞体アミノペプチダーゼ;脂肪細胞由来ロイシンアミノペプチダーゼ;白血球由来アルギニンアミノペプチダーゼ;小胞体貯留機構;MHCクラスI抗原ペプチド;X線結晶構造解析;アミノペプチダーゼ;胎盤性ロイシンアミノペプチダーゼ;オキシトシナーゼサブファミリー;遺伝子発現調節機構

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16790072/
• 血管新生の制御を目指した新たな標的分子の探索

  Grant-in-Aid for Exploratory Research

  The Institute of Physical and Chemical Research

  辻本 雅文

  From 01 Apr. 2004, To 31 Mar. 2006, Project Closed

  アミノペプチダーゼ;脂肪細胞由来ロイシンアミノペプチダーゼ;白血球由来アルギニンアミノペプチダーゼ;血管新生;HuVEC;インターフェロン-γ;胎盤性ロイシンアミノペプチダーゼ;アミノペプチダーゼA;オキシトシナーゼサブファミリー;阻害剤;大量発現系

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16659025/
• The oxytocinase subfamily of M1 aminopeptidases

  Grant-in-Aid for Scientific Research (B)

  RIKEN

  Masafumi TSUJIMOTO

  From 01 Apr. 2003, To 31 Mar. 2006, Project Closed

  アミノペプチダーゼ;オキシトシナーゼサブファミリー;胎盤性ロイシンアミノペプチダーゼ;脂肪細胞由来ロイシンアミノペプチダーゼ;白血球由来アルギニンアミノペブチダーゼ;腎尿細管細胞;MHCクラスI抗原ペプチド;小胞体内貯留;白血球由来アルギニンアミノペプチダーゼ;抗原ペプチド;小胞体貯留;本態性高血圧症;高血圧症;大量発現系;腎尿細管;小胞体貯留機構;バソプレシン, Aminopeptidase;Oxytocinase Subfamily;Placental Leucine Aminopeptidase;Adipocyte-derived Leucine Aminopeptidase;Leukocyte-derived Arginine Aminopeptidase;NRK52E Cells;MHC Class I Antigenic Peptides;ER Retention Mechanism

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15390032/
• オキシトシナーゼサブファミリーの細胞内膜系局在の意義およびそのメカニズムの解明

  Grant-in-Aid for Young Scientists (B)

  The Institute of Physical and Chemical Research

  服部 明

  From 01 Apr. 2002, To 31 Mar. 2004, Project Closed

  脂肪細胞由来ロイシンアミノペプチダーゼ;胎盤性ロイシンアミノペプチダーゼ;白血球由来アルギニンアミノペプチダーゼ;オキシトシナーゼサブファミリー;MHCクラスI抗原ペプチド;小胞体内腔可溶性タンパク質;小胞体貯留機構;酵母Two-Hybrid法;脂肪細胞由来ロイシンアミノペプチターゼ;小胞体;内在性抗原生成;インターフェロン-γ;ウィルス感染;タンパク質結晶化;X線結晶構造解析

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14771302/
• オキシトシナーゼサブファミリーに属する新規酵素の生理機能の解明

  Grant-in-Aid for Encouragement of Young Scientists (A)

  理化学研究所

  服部 明

  From 01 Apr. 2000, To 31 Mar. 2002, Project Closed

  アミノペプチダーゼ;オキシトシナーゼ;胎盤性ロイシンアミノペプチダーゼ;脂肪細胞由来ロイシンアミノペプチダーゼ;オキシトシナーゼサブファミリー;遺伝子構造;プロモーター領域;X線結晶構造解析;ペプチドホルモン;金属酵素;CHO細胞;血圧調節

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12771424/
• STRUCTURE AND FUNCTION OF NOVEL AMINOPEPTIDASES BELONGING TO OXYTOCINASE SUB-FAMILY

  Grant-in-Aid for Scientific Research (B)

  Riken

  Masafumi TSUJIMOTO

  From 01 Apr. 1999, To 31 Mar. 2002, Project Closed

  アミノペプチダーゼ;オキシトシナーゼ;胎盤性ロイシンアミノペプチダーゼ;脂肪細胞由来ロイシンアミノペプチダーゼ;生理活性ペプチド;バソプレシン;血圧調節;遺伝子クローニング;尿細管;プロモーター領域;神経細胞;ペプチドホルモン;CHO細胞;タンパク質結晶化;金属酵素;胎盤性ロイシンアミノペプチターゼ, AMINOPEPTIDASE;OXYTOCINASE;PLACENTAL LEUCINE AMINOPEPTIDASE;ADIPOCYTE-DERIVED LEUCINE AMINBOPEPTIDASE;BIOACTIVE PEPTIDE;VASOPRESSIN;BLOOD PRESSURE;cDNA CLONING

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11470492/
• 腫瘍壊死因子によるアポトーシス誘導のシグナル系におけるcPLA_2の役割の解明

  Grant-in-Aid for Encouragement of Young Scientists (A)

  理化学研究所

  服部 明

  From 01 Apr. 1998, To 31 Mar. 2000, Project Closed

  腫瘍壊死因子;アポトーシス;細胞内シグナル伝達系;cPLA2;Caspase;阻害剤;インテグリン;L929細胞;細胞質ホスホリパーゼA2;MAPキナーゼファミリー;COX-2;セラミド;シグナル伝達

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10780393/
• Roles of the ubiquitin protein modification in the maintenance of epithelial cell-cell adhesion

  Grant-in-Aid for Scientific Research (C)

  Basic Section 47050:Environmental and natural pharmaceutical resources-related

  Kyoto University

  AKIRA HATTORI

  From 01 Apr. 2022, To 31 Mar. 2025, Project Closed

  翻訳後修飾;ユビキチン;脱ユビキチン化;上皮細胞;上皮間葉転換;E-Cadherin;Catenin D1;脱ユビキチン化修飾;ユビキチン化修飾;細胞間接着;USP47;EPLIN;脱ユビキチン化酵素;p120カテニン;ユビキチン添加酵素

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K06677/
• 脈管内がん幹細胞の胚シグナル分子による微小環境形成機構とそれを標的にした治療戦略

  Grant-in-Aid for Challenging Research (Pioneering)

  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields

  Kanazawa University

  藤原 浩

  From 30 Jun. 2022, To 31 Mar. 2026, Granted

  がん幹細胞;胚シグナル;微小環境形成

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K18396/
• 分子ひずみを活用する生体機能分子の創出

  Grant-in-Aid for Scientific Research (B)

  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related

  Kyoto University

  高須 清誠

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  分子ひずみ;生物活性分子;有機合成;多環芳香族炭化水素;分子不斉

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23H02604/
• 分子ひずみを活用する生体機能分子の創出

  Grant-in-Aid for Scientific Research (B)

  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related

  Kyoto University

  高須 清誠

  From 01 Apr. 2024, To 31 Mar. 2026, Granted

  ひずみ分子;クリック反応剤;不斉合成;ラセミ化;分子ひずみ;生物活性分子;フロー合成;多環芳香族炭化水素;有機合成;ひずみ化合物;構造解析;不斉反応;フロー反応;分子不斉

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K27295/
• がん悪性化の共通制御点を形成するユビキチン修飾反応の解明とその創薬への応用

  Grant-in-Aid for Scientific Research (C)

  Basic Section 47050:Environmental and natural pharmaceutical resources-related

  Kyoto University

  服部 明

  From 01 Apr. 2025, To 31 Mar. 2028, Granted

  脱ユビキチン化修飾;ユビキチン化酵素;翻訳後修飾;がん悪性化;抗腫瘍薬

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25K10013/

External funds: others

• 高感度アミノペプチダーゼ定量法の開発と疾患診断法への応用化の検討

  JST産学共同シーズイノベーション化事業

  From 01 Oct. 2005, To 30 Sep. 2006

  服部　明

Education

Teaching subject(s)

• From 01 Apr. 2025, To 31 Mar. 2026

  Advanced Organic Chemistry for Drug Discovery A

  8203, Fall, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  Research Proposal Writing Practice A

  8402, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  Pharmaceutical Laboratory Coaching Practice B

  8302, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  Pharmaceutical Laboratory Coaching Practice A

  8301, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  Research Proposal Writing Practice B

  8403, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  Pharmacognosy III (Applied Pharmacognosy and Kampo)

  C008, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Pharmacognogy I

  C006, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Pharmacognosy 3 (Applied Pharmacognosy)

  A008, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Pharmacognogy 1 (Natural Product Chemistry)

  A006, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Advanced Basic Organic Chemistry I

  1209, Fall, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Basic Laboratory Techniques in Organic Chemistry

  1205, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Introduction to Organic Chemistry for Drug Discovery

  1026, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Introduction to Pharmaceutical Sciences

  6002, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Introduction to Organic Chemistry for Drug Discovery

  8102, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  ２１ＣＯＥ化学講義３（理）

  8001, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Advanced Pharmaceutical Sciences I

  6005, Fall, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Seminar on Critical Reading of Scientific Papers B

  8405, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Seminar on Critical Reading of Scientific Papers A

  8404, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Medicinal Frontier Science Research A

  8406, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2025, To 31 Mar. 2026

  Medicinal Frontier Science Research C

  8408, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2025, To 31 Mar. 2026

  Medicinal Frontier Science Research B

  8407, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2025, To 31 Mar. 2026

  Pharmaceutical Laboratory II : Organic Chemistry

  C902, Spring, Faculty of Pharmaceutical Sciences, 3
• From 01 Apr. 2024, To 31 Mar. 2025

  Research Proposal Writing Practice B

  8403, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Research Proposal Writing Practice A

  8402, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Pharmaceutical Laboratory Coaching Practice B

  8302, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Pharmaceutical Laboratory Coaching Practice A

  8301, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Organic Chemistry for Drug Discovery B

  8204, Fall, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Pharmacognogy I

  C006, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Pharmacognosy 3 (Applied Pharmacognosy)

  A008, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Pharmacognogy 1 (Natural Product Chemistry)

  A006, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Pharmacognosy III (Applied Pharmacognosy and Kampo)

  C008, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Medicinal Frontier Science Research C

  8408, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Pharmaceutical Laboratory II : Organic Chemistry

  C902, Spring, Faculty of Pharmaceutical Sciences, 3
• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Pharmaceutical Sciences

  6002, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Basic Organic Chemistry II

  1210, Fall, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Organic Chemistry for Drug Discovery

  1026, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar on Critical Reading of Scientific Papers A

  8404, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Organic Chemistry for Drug Discovery

  8102, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  ２１ＣＯＥ化学講義３（理）

  8001, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar on Critical Reading of Scientific Papers B

  8405, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Medicinal Frontier Science Research B

  8407, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Medicinal Frontier Science Research A

  8406, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Pharmaceutical Laboratory Coaching Practice A

  8301, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Research Proposal Writing Practice B

  8403, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Research Proposal Writing Practice A

  8402, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Pharmaceutical Laboratory Coaching Practice B

  8302, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Pharmaceutical Laboratory II : Organic Chemistry

  C902, Spring, Faculty of Pharmaceutical Sciences, 3
• From 01 Apr. 2023, To 31 Mar. 2024

  Skill Development for Lead Discovery

  5102, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Medicinal Frontier Science Research B

  8407, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Medicinal Frontier Science Research A

  8406, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Research in Systems Biology & Drug Dicovery

  5301, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Pharmaceutical Laboratory 2 : Organic Chemistry

  A902, Spring, Faculty of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Pharmaceutical Sciences

  6002, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Methods in Systems Biology & Drug Discovery

  5501, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Organic Chemistry for Drug Discovery

  1026, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar on Critical Reading of Scientific Papers B

  8405, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar on Critical Reading of Scientific Papers A

  8404, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Organic Chemistry for Drug Discovery

  8102, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Pharmacognosy III (Applied Pharmacognosy and Kampo)

  C008, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Pharmacognogy I

  C006, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Pharmacognosy 3 (Applied Pharmacognosy)

  A008, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Pharmacognogy 1 (Natural Product Chemistry)

  A006, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Medical Frontier Science Research A

  8406, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Pharmacognogy I

  C006, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Methods in Systems Biology & Drug Discovery

  5501, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Research Proposal Writing Practice A

  8402, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  ILAS Seminar

  Z001, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar on Critical Reading of Scientific Papers A

  8404, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Introduction to Organic Chemistry for Drug Discovery

  8102, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Pharmacognosy III (Applied Pharmacognosy and Kampo)

  C008, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Research in Systems Biology & Drug Dicovery

  5301, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Pharmaceutical Laboratory Coaching Practice A

  8301, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Organic Chemistry for Drug Discovery B

  8204, Fall, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Introduction to Organic Chemistry for Drug Discovery

  1026, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Pharmaceutical Laboratory 2 : Organic Chemistry

  A902, Spring, Faculty of Pharmaceutical Sciences, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Skill Development for Lead Discovery

  5102, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Pharmacognogy 1 (Natural Product Chemistry)

  A006, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Drug Discovery & Development II: Lead Discovery Technology

  1111, Fall, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Basic Organic Chemistry II

  1210, Fall, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Pharmaceutical Laboratory II : Organic Chemistry

  C902, Spring, Faculty of Pharmaceutical Sciences, 3
• From Apr. 2011, To Mar. 2012

  Drug Discovery & Development II:

  Fall, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Skill Development for Lead Discovery

  Year-long, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Skill Development for Lead Discovery

  Year-long, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Organic Chemistry of Pharmaceuticals

  Spring, 全学共通科目
• From Apr. 2011, To Mar. 2012

  Introduction to Drug Discovery Sciences

  Spring, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Advanced Drug Discovery & Development I

  Spring, 薬学研究科
• From Apr. 2011, To Mar. 2012

  医薬品化学・新薬論

  Fall, 薬学部
• From Apr. 2011, To Mar. 2012

  天然物薬学２（薬用資源学）

  Fall, 薬学部
• From Apr. 2011, To Mar. 2012

  新薬論

  Fall, 薬学部
• From Apr. 2011, To Mar. 2012

  Advanced Methods in Systems

  Year-long, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Advanced Methods in Systems

  Year-long, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Research in Systems

  Year-long, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Research in Systems

  Year-long, 薬学研究科
• From Apr. 2011, To Mar. 2012

  薬学専門実習II

  Spring, 薬学部
• From Apr. 2011, To Mar. 2012

  薬学専門実習２

  Spring, 薬学部
• From Apr. 2011, To Mar. 2012

  薬用資源学

  Fall, 薬学部
• From Apr. 2012, To Mar. 2013

  Drug Discovery & Development II: Lead Discovery Technology

  Fall, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Skill Development for Lead Discovery

  Year-long, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Introduction to Drug Discovery Sciences

  Spring, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Medicinal Chemistry and Drug Discovery

  Fall, 薬学部
• From Apr. 2012, To Mar. 2013

  Pharmacognosy 2 (Pharmaceutical Resources)

  Fall, 薬学部
• From Apr. 2012, To Mar. 2013

  Discovery and Developmennt of New Drugs

  Fall, 薬学部
• From Apr. 2012, To Mar. 2013

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Research in Systems Biology & Drug Dicovery

  Year-long, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Pharmaceutical Laboratory II:Organic Chemistry

  Spring, 薬学部
• From Apr. 2012, To Mar. 2013

  Pharmaceutical Laboratory 2 : Organic Chemistry

  Spring, 薬学部
• From Apr. 2012, To Mar. 2013

  Pharmaceutical Resources

  Fall, 薬学部
• From Apr. 2013, To Mar. 2014

  Pharmacognogy 1 (Natural Product Chemistry)

  Spring, 薬学部
• From Apr. 2013, To Mar. 2014

  Pharmaceutical Laboratory 2 : Organic Chemistry

  Spring, 薬学部
• From Apr. 2013, To Mar. 2014

  Introduction to Drug Discovery Sciences

  Spring, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Skill Development for Lead Discovery

  Year-long, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Research in Systems Biology & Drug Dicovery

  Year-long, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Organic Chemistry of Pharmaceuticals

  Spring, 全学共通科目
• From Apr. 2014, To Mar. 2015

  Pharmacognogy 1 (Natural Product Chemistry)

  Spring, 薬学部
• From Apr. 2014, To Mar. 2015

  Pharmaceutical Laboratory 2 : Organic Chemistry

  Spring, 薬学部
• From Apr. 2014, To Mar. 2015

  Introduction to Drug Discovery Sciences

  Spring, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Drug Discovery & Development II: Lead Discovery Technology

  Fall, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Skill Development for Lead Discovery

  Year-long, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Research in Systems Biology & Drug Dicovery

  Year-long, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Organic Chemistry of Pharmaceuticals

  Spring, 全学共通科目
• From Apr. 2015, To Mar. 2016

  Skill Development for Lead Discovery

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Organic Chemistry of Pharmaceuticals

  Spring, 全学共通科目
• From Apr. 2015, To Mar. 2016

  Introduction to Drug Discovery Sciences

  Spring, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Pharmacognogy 1 (Natural Product Chemistry)

  Spring, 薬学部
• From Apr. 2015, To Mar. 2016

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Research in Systems Biology & Drug Dicovery

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Pharmaceutical Laboratory 2 : Organic Chemistry

  Spring, 薬学部
• From Apr. 2016, To Mar. 2017

  Drug Discovery & Development II: Lead Discovery Technology

  Fall, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Skill Development for Lead Discovery

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Introduction to Drug Discovery Sciences

  Spring, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Pharmacognogy 1 (Natural Product Chemistry)

  Spring, 薬学部
• From Apr. 2016, To Mar. 2017

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Research in Systems Biology & Drug Dicovery

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Pharmaceutical Laboratory 2 : Organic Chemistry

  Spring, 薬学部
• From Apr. 2017, To Mar. 2018

  ILAS Seminar

  Spring, 全学共通科目
• From Apr. 2017, To Mar. 2018

  Introduction to Organic Chemistry for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Skill Development for Lead Discovery

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Pharmacognogy 1 (Natural Product Chemistry)

  Spring, 薬学部
• From Apr. 2017, To Mar. 2018

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Research in Systems Biology & Drug Dicovery

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Pharmaceutical Laboratory 2 : Organic Chemistry

  Spring, 薬学部
• From Apr. 2018, To Mar. 2019

  Drug Discovery & Development II: Lead Discovery Technology

  Fall, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Introduction to Organic Chemistry for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Skill Development for Lead Discovery

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Advanced Basic Organic Chemistry II

  Fall, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Fundamental Chemical Experiments

  Fall, 全学共通科目
• From Apr. 2018, To Mar. 2019

  Pharmacognogy 1 (Natural Product Chemistry)

  Spring, 薬学部
• From Apr. 2018, To Mar. 2019

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Research in Systems Biology & Drug Dicovery

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Research in Systems Biology & Drug Dicovery

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Pharmaceutical Laboratory 2 : Organic Chemistry

  Spring, 薬学部
• From Apr. 2019, To Mar. 2020

  Introduction to Organic Chemistry for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Skill Development for Lead Discovery

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Skill Development for Lead Discovery

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Pharmacognogy I

  Spring, 薬学部
• From Apr. 2019, To Mar. 2020

  Pharmacognogy 1 (Natural Product Chemistry)

  Spring, 薬学部
• From Apr. 2019, To Mar. 2020

  Advanced Methods in Systems Biology & Drug Discovery

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Advanced Methods in Systems Biology & Drug Discovery

  Fall, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Research in Systems Biology & Drug Dicovery

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Research in Systems Biology & Drug Dicovery

  Fall, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Research in Systems Biology & Drug Dicovery

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Pharmaceutical Laboratory 2 : Organic Chemistry

  Spring, 薬学部
• From Apr. 2020, To Mar. 2021

  ILAS Seminar :Organic Chemistry of Pharmaceuticals

  Spring, 全学共通科目
• From Apr. 2020, To Mar. 2021

  Drug Discovery & Development II: Lead Discovery Technology

  Fall, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Introduction to Organic Chemistry for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Skill Development for Lead Discovery

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Skill Development for Lead Discovery

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Advanced Basic Organic Chemistry II

  Fall, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Pharmacognogy I (Natural Product Chemistry)

  Spring, 薬学部
• From Apr. 2020, To Mar. 2021

  Pharmacognogy 1 (Natural Product Chemistry)

  Spring, 薬学部
• From Apr. 2020, To Mar. 2021

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Advanced Methods in Systems Biology & Drug Discovery

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Advanced Methods in Systems Biology & Drug Discovery

  Fall, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Research in Systems Biology & Drug Dicovery

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Research in Systems Biology & Drug Dicovery

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Research in Systems Biology & Drug Dicovery

  Fall, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Pharmaceutical Laboratory II : Organic Chemistry

  Spring, 薬学部
• From Apr. 2020, To Mar. 2021

  Pharmaceutical Laboratory 2 : Organic Chemistry

  Spring, 薬学部
• From Apr. 2021, To Mar. 2022

  Introduction to Organic Chemistry for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Skill Development for Lead Discovery

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Pharmacognogy I (Natural Product Chemistry)

  Spring, 薬学部
• From Apr. 2021, To Mar. 2022

  Pharmacognogy 1 (Natural Product Chemistry)

  Spring, 薬学部
• From Apr. 2021, To Mar. 2022

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Research in Systems Biology & Drug Dicovery

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Pharmaceutical Laboratory II : Organic Chemistry

  Spring, 薬学部
• From Apr. 2021, To Mar. 2022

  Pharmaceutical Laboratory 2 : Organic Chemistry

  Spring, 薬学部

Administration

School management (title, position)

• From 01 Apr. 2025, To 31 Mar. 2027

  組換えDNA実験安全委員会 委員
• From 01 Apr. 2024, To 31 Mar. 2027

  組換えDNA実験安全委員会 委員
• From 01 Apr. 2023, To 31 Mar. 2025

  環境安全保健機構　化学物質専門小委員会　委員
• From 01 Apr. 2023, To 31 Mar. 2025

  化学物質専門委員会　委員
• From 01 Apr. 2023, To 31 Mar. 2025

  環境科学センター　有機廃液情報管理小委員会　委員
• From 01 Apr. 2012, To 31 Mar. 2014

  ジュニアキャンパス実施検討会
• From 01 Apr. 2013, To 31 Mar. 2015

  京都大学組み換えDNA実験安全委員会 委員
• From 01 Apr. 2014, To 31 Mar. 2016

  ジュニアキャンパス実施検討会 委員
• From 01 Apr. 2012, To 31 Mar. 2016

  ジュニアキャンパス実施検討会 委員
• From 01 Apr. 2015, To 31 Mar. 2017

  組換えDNA実験安全委員会 1号委員

Faculty management (title, position)

• From 01 Apr. 2024, To 31 Mar. 2025

  実験動物施設運営委員会　委員
• From 01 Apr. 2024, To 31 Mar. 2025

  教務委員会　委員
• From 01 Apr. 2022, To 31 Mar. 2026

  薬用植物園管理者
• From 01 Apr. 2022, To 31 Mar. 2026

  薬用植物園管理委員会　委員
• From 01 Apr. 2011, To 31 Mar. 2013

  共用試験委員会　委員
• From 01 Apr. 2012, To 31 Mar. 2014

  ホームページ広報委員会　委員
• From 01 Apr. 2014, To 31 Mar. 2015

  ホームページ広報委員会　委員長
• From 01 Apr. 2015, To 31 Mar. 2024

  ホームページ広報委員会　委員
• From 01 Apr. 2013, To 31 Mar. 2015

  学生委員　委員
• From 01 Apr. 2013

  組換えDNA実験安全主任者
• From 01 Apr. 2011, To 31 Mar. 2018

  図書委員会　委員
• From 01 Apr. 2011, To 31 Mar. 2025

  動物実験委員会　委員
• From 01 Apr. 2011, To 31 Mar. 2025

  環境・安全衛生委員会　委員
• From 01 Apr. 2011

  ＲＩ管理委員会　委員