Basic Information

Email Address

• Email Address

  jiko.chimari.4skyoto-u.ac.jp

Professional Memberships

• 日本結晶学会
• 日本蛋白質科学会

Academic Degree

• 24 Mar. 2006

  大阪大学修士（理学）
• 16 Dec. 2009

  大阪大学博士（理学）

Academic Resume (Graduate Schools)

• 大阪大学, 大学院理学研究科博士後期課程高分子科学専攻, 修了
• 大阪大学, 大学院理学研究科博士後期課程高分子科学専攻, 単位修得退学
• 大阪大学, 大学院理学研究科博士前期課程高分子科学専攻, 修了

Academic Resume (Undergraduate School/Majors)

• 名古屋大学, 工学部化学生物工学科, 卒業

ID,URL

• J-Global ID

  202301001541181584

• Researcher number

  70585976

researchmap URL

• https://researchmap.jp/chimari.jiko

Research

Research Areas

• Life sciences, Structural biochemistry

Papers

• Corrigendum to "Human F-ATP synthase as a drug target" [Pharmacol. Res. 209 (2024) 107423].

  Christoph Gerle; Chimari Jiko; Atsuki Nakano; Ken Yokoyama; Chai C Gopalasingam; Hideki Shigematsu; Kazuhiro Abe

  Pharmacological research, Nov. 2024

  
• Human F-ATP synthase as a drug target.

  Christoph Gerle; Chimari Jiko; Atsuki Nakano; Ken Yokoyama; Chai C Gopalasingam; Hideki Shigematsu; Kazuhiro Abe

  Pharmacological research, 19 Sep. 2024

  
• NDT‐C11 as a viable novel detergent for single particle cryo‐EM

  Chimari Jiko; Jiannan Li; Youngsun Moon; Yoshito Tanaka; Chai C. Gopalasingam; Hideki Shigematsu; Pil Seok Chae; Genji Kurisu; Christoph Gerle

  ChemPlusChem, 17 Jun. 2024, Peer-reviewed, Lead author

  
• Large-scale column-free purification of bovine F-ATP synthase.

  Chimari Jiko; Yukio Morimoto; Tomitake Tsukihara; Christoph Gerle

  The Journal of biological chemistry, Feb. 2024

  
• Inhibition of ATP synthase reverse activity restores energy homeostasis in mitochondrial pathologies.

  Rebeca Acin-Perez; Cristiane Benincá; Lucia Fernandez Del Rio; Cynthia Shu; Siyouneh Baghdasarian; Vanessa Zanette; Christoph Gerle; Chimari Jiko; Ramzi Khairallah; Shaharyar Khan; David Rincon Fernandez Pacheco; Byourak Shabane; Karel Erion; Ruchi Masand; Sundeep Dugar; Cristina Ghenoiu; George Schreiner; Linsey Stiles; Marc Liesa; Orian S Shirihai

  The EMBO journal, 15 May 2023

  
• Rapid and Highly Stable Membrane Reconstitution by LAiR Enables the Study of Physiological Integral Membrane Protein Functions.

  Albert Godoy-Hernandez; Amer H Asseri; Aiden J Purugganan; Chimari Jiko; Carol de Ram; Holger Lill; Martin Pabst; Kaoru Mitsuoka; Christoph Gerle; Dirk Bald; Duncan G G McMillan

  ACS central science, 22 Mar. 2023

  
• Purified F-ATP synthase forms a Ca2+-dependent high-conductance channel matching the mitochondrial permeability transition pore.

  Andrea Urbani; Valentina Giorgio; Andrea Carrer; Cinzia Franchin; Giorgio Arrigoni; Chimari Jiko; Kazuhiro Abe; Shintaro Maeda; Kyoko Shinzawa-Itoh; Janna F M Bogers; Duncan G G McMillan; Christoph Gerle; Ildikò Szabò; Paolo Bernardi

  Nature communications, 25 Sep. 2019

  
• Protein assemblies ejected directly from native membranes yield complexes for mass spectrometry.

  Dror S Chorev; Lindsay A Baker; Di Wu; Victoria Beilsten-Edmands; Sarah L Rouse; Tzviya Zeev-Ben-Mordehai; Chimari Jiko; Firdaus Samsudin; Christoph Gerle; Syma Khalid; Alastair G Stewart; Stephen J Matthews; Kay Grünewald; Carol V Robinson

  Science (New York, N.Y.), 16 Nov. 2018

  
• Structural Basis for Selective Binding of Export Cargoes by Exportin-5.

  Ryuji Yamazawa; Chimari Jiko; Saehae Choi; Il Yeong Park; Atsushi Nakagawa; Eiki Yamashita; Soo Jae Lee

  Structure (London, England : 1993), 02 Oct. 2018

  
• Bovine F1Fo ATP synthase monomers bend the lipid bilayer in 2D membrane crystals.

  Chimari Jiko; Karen M Davies; Kyoko Shinzawa-Itoh; Kazutoshi Tani; Shintaro Maeda; Deryck J Mills; Tomitake Tsukihara; Yoshinori Fujiyoshi; Werner Kühlbrandt; Christoph Gerle

  eLife, 27 Mar. 2015

  
• Two-dimensional crystallization of intact F-ATP synthase isolated from bovine heart mitochondria.

  Shintaro Maeda; Kyoko Shinzawa-Itoh; Kaoru Mieda; Mami Yamamoto; Yumiko Nakashima; Yumi Ogasawara; Chimari Jiko; Kazutoshi Tani; Atsuo Miyazawa; Christoph Gerle; Shinya Yoshikawa

  Acta crystallographica. Section F, Structural biology and crystallization communications, Dec. 2013

  
• Selective nuclear export mechanism of small RNAs.

  Soo Jae Lee; Chimari Jiko; Eiki Yamashita; Tomitake Tsukihara

  Current opinion in structural biology, Feb. 2011

  
• A high-resolution structure of the pre-microRNA nuclear export machinery.

  Chimari Okada; Eiki Yamashita; Soo Jae Lee; Satoshi Shibata; Jun Katahira; Atsushi Nakagawa; Yoshihiro Yoneda; Tomitake Tsukihara

  Science (New York, N.Y.), 27 Nov. 2009

  

Misc.

• Preparation of mammalian mitochondrial FoF1ATP synthase for high-resolution structural analysis

  慈幸千真理; 三角裕子; 栗栖源嗣; 森本幸生; 月原冨武; GERLE Christoph

  日本生体エネルギー研究会討論会講演要旨集, 2023

  
• Development of a novel purification method and structural analysis of mammalian FoF1ATP synthase

  慈幸千真理; 中野敦樹; 三角裕子; 山下栄樹; 栗栖源嗣; 森本幸生; 月原冨武; 横山謙; GERLE Christoph

  KURNS-EKR (Web), 2024

  
• クライオ電顕のための牛心筋FoF1ATP合成酵素の試料調製

  慈幸千真理; GERLE Christoph; 森本幸生

  KURNS-EKR (Web), 2019

  
• 哺乳動物のミトコンドリアFoF1ATP合成酵素完全複合体の精製

  慈幸千真理; 森本幸生; CHRISTOPH Gerle

  日本生体エネルギー研究会討論会講演要旨集, 2017

  
• 核外輸送に置けるExportin-5の構造基盤

  山澤龍治; 小林武; 慈幸千真理; 月原冨武; 中川敦史; 山下栄樹

  日本蛋白質科学会年会プログラム・要旨集, 2015

  
• リガンドフリー型Exportin-5の構造解析

  山澤龍治; 小林武; 慈幸千真理; 李守宰; 中川敦史; 柴田理志; 岡正啓; 片平じゅん; 米田悦啓; 月原冨武; 月原冨武; 山下栄樹

  日本結晶学会年会講演要旨集, 2013

  
• Exportin-5によるRNAsの核外輸送メカニズムの解明

  山澤龍治; 山下栄樹; LEE Soo Jae; 慈幸千真理; 柴田理志; 片平じゅん; 中川敦史; 米田悦啓; 月原冨武

  日本蛋白質科学会年会プログラム・要旨集, 2012

  
• microRNA核外輸送複合体のX線結晶構造解析

  慈幸千真理; 山下栄樹; 李守宰; 柴田理志; 片平じゅん; 中川敦史; 米田悦啓; 月原冨武; 月原冨武

  日本蛋白質科学会年会プログラム・要旨集, 2010

  
• microRNA核外輸送複合体のX線結晶構造解析

  慈幸千真理; 山下栄樹; 李守宰; 柴田理志; 片平じゅん; 中川敦史; 米田悦啓; 月原冨武; 月原冨武

  日本蛋白質科学会年会プログラム・要旨集, 2010

  
• pre-microRNA核外輸送複合体のX線結晶構造解析

  山下栄樹; 慈幸千真理; LEE Soo Jae; 柴田理志; 片平じゅん; 中川敦史; 米田悦啓; 月原冨武; 月原冨武

  生化学, 2010

  
• microRNA前駆体の核外輸送複合体のX線構造解析

  慈幸 千真理

  日本結晶学会誌, 2010

  

Awards

• 18 Jun. 2010

  ２０１０年度日本蛋白質科学会年会若手奨励賞

External funds: Kakenhi

• 哺乳動物ミトコンドリアFoF1ATP合成酵素高次集合体の構造解析

  Grant-in-Aid for Scientific Research (C)

  Basic Section 43040:Biophysics-related

  Kyoto University

  慈幸 千真理

  From 01 Apr. 2023, To 31 Mar. 2028, Granted

  ATP合成酵素;ミトコンドリア;オリゴマー

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K05716/
• High resolution and dynamic structural analysis of the entire mammalian FoF1ATP synthase

  Grant-in-Aid for Early-Career Scientists

  Basic Section 38030:Applied biochemistry-related

  Kyoto University

  Chimari Jiko

  From 01 Apr. 2019, To 31 Mar. 2023, Project Closed

  Fo F1ATP合成酵素;ミトコンドリア;単粒子構造解析;ATP合成酵素;膜タンパク質複合体;膜蛋白質複合体;精製;界面活性剤;膜タンパク質

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K15749/