Basic Information

Concurrent Affiliation

• Open Innovation Institute, 研究代表者

Academic Degree

• 修士（農学）(京都大学)
• 博士（医学）(京都大学)

ID,URL

• J-Global ID

  202001018331570390

researchmap URL

• https://researchmap.jp/yukakobayashi

Research

Papers

• Artificial Construction of Immune Tissues/Organoids and Their Application for Immunological Intervention.

  Yuka Kobayashi; Takeshi Watanabe

  Current topics in microbiology and immunology, 02 Jun. 2020, Peer-reviewed

  
• Cytotoxic T Lymphocytes Regenerated from iPS Cells Have Therapeutic Efficacy in a Patient-Derived Xenograft Solid Tumor Model.

  Soki Kashima; Takuya Maeda; Kyoko Masuda; Seiji Nagano; Takamitsu Inoue; Masashi Takeda; Yuka Kono; Takashi Kobayashi; Shigeyoshi Saito; Takahiro Higuchi; Hiroshi Ichise; Yuka Kobayashi; Keiko Iwaisako; Koji Terada; Yasutoshi Agata; Kazuyuki Numakura; Mitsuru Saito; Shintaro Narita; Masaki Yasukawa; Osamu Ogawa; Tomonori Habuchi; Hiroshi Kawamoto

  iScience, 24 Apr. 2020, Peer-reviewed

  Access this paper :

  
• Engineering of artificial lymph node

  Makoto Nakamura; Kenichi Arai; Takahito Mimura; Jungo Tagawa; Hirotoshi Yoshida; Koichi Kato; Tadashi Nakaji-Hirabayashi; Yuka Kobayashi; Takeshi Watanabe

  Synthetic Immunology, 01 Jan. 2016, Peer-reviewed

  
• Synthesis of functional tertiary lymphoid organs

  Yuka Kobayashi; Koichi Kato; Makoto Nakamura; Takeshi Watanabe

  Synthetic Immunology, 01 Jan. 2016, Peer-reviewed

  
• Gel-Trapped Lymphorganogenic Chemokines Trigger Artificial Tertiary Lymphoid Organs and Mount Adaptive Immune Responses In Vivo.

  Yuka Kobayashi; Takeshi Watanabe

  Frontiers in immunology, 2016, Peer-reviewed

  
• Synthesis of functional artificial lymphoid tissues.

  Yuka Kobayashi; Koichi Kato; Takeshi Watanabe

  Discovery medicine, Oct. 2011, Peer-reviewed

  
• Synthesis of artificial lymphoid tissue with immunological function.

  Yuka Kobayashi; Takeshi Watanabe

  Trends in immunology, Nov. 2010, Peer-reviewed

  
• Similar and distinct properties of MUPP1 and Patj, two homologous PDZ domain-containing tight-junction proteins.

  Makoto Adachi; Yoko Hamazaki; Yuka Kobayashi; Masahiko Itoh; Sachiko Tsukita; Mikio Furuse; Shoichiro Tsukita

  Molecular and cellular biology, May 2009, Peer-reviewed

  
• Identification of adherens junction-associated GTPase activating proteins by the fluorescence localization-based expression cloning.

  Miho Matsuda; Yuka Kobayashi; Sayuri Masuda; Makoto Adachi; Tsuyoshi Watanabe; Jun K Yamashita; Eiichiro Nishi; Shoichiro Tsukita; Mikio Furuse

  Experimental cell research, 10 Mar. 2008, Peer-reviewed

  
• 蛍光局在に基づく発現クローニングによる接着結合関連GTPase活性化タンパク質の同定(Identification of adherens junction-associated GTPase activating proteins by the fluorescence localization-based expression cloning)

  小林 由佳; 松田 美穂; 増田 小百合; 足立 誠; 月田 承一郎; 古瀬 幹夫

  日本発生生物学会・日本細胞生物学会合同大会要旨集, May 2007

  
• Molecular characterization of angiomotin/JEAP family proteins: interaction with MUPP1/Patj and their endogenous properties.

  Yuko Sugihara-Mizuno; Makoto Adachi; Yuka Kobayashi; Yoko Hamazaki; Miyuki Nishimura; Toshio Imai; Mikio Furuse; Shoichiro Tsukita

  Genes to cells : devoted to molecular & cellular mechanisms, Apr. 2007, Peer-reviewed

  

Misc.

• Direct repression of the gene expression of claudins/occludin by Snail: Towards the identification of epithelium-specific genes

  Junichi Ikenouchi; Miho Matsuda; Yuka Kobayashi; Noriko Iwamoto; Mikio Furuse; Shoichiro Tsukita

  CELL STRUCTURE AND FUNCTION, May 2004

  

External funds: Kakenhi

• ヒト型人工リンパ組織の開発と腫瘍への免疫療法の応用

  Grant-in-Aid for Scientific Research (C)

  Basic Section 50020:Tumor diagnostics and therapeutics-related

  Kyoto University

  小林 由佳

  From 01 Apr. 2021, To 31 Mar. 2024, Granted

  三次リンパ組織;ストローマ細胞;ケモカイン;T細胞;B細胞;ヒト免疫反応;リンパ組織;がん免疫;抗腫瘍活性;腫瘍免疫

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K07174/
• A construction of the functional human type artificial lymphoid tissues toward the the application for antitumor immunotherapy

  Grant-in-Aid for Scientific Research (C)

  Basic Section 50020:Tumor diagnostics and therapeutics-related

  Kyoto University

  Yuka Kobayashi

  From 01 Apr. 2018, To 31 Mar. 2021, Project Closed

  三次リンパ組織;人工的構築;リンパ組織;抗腫瘍活性;ストローマ細胞;T細胞;B細胞;がん免疫;ケモカイン;リンパ節;がん;抗腫瘍免疫

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K07264/
• Analysis and application of memory T and memory B cells by applying artificial lymph nodes

  Grant-in-Aid for Scientific Research (B)

  Kyoto University;The Institute of Physical and Chemical Research

  Takeshi WATANABE

  From 01 Apr. 2007, To 31 Mar. 2009, Project Closed

  人工免疫組織;リンパ節;記憶T細胞;記憶B細胞;濾胞性ヘルパーT細胞;感染症治療;腫瘍免疫;再生医学;重症感染症の治療;人工リンパ節;メモリーT細胞;メモリーB細胞;抗原特異的二次免疫反応;免疫組織再生;ワクチン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19390142/
• Generation and application of artificial lymphoid tissues

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University;The Institute of Physical and Chemical Research

  Takeshi WATANABE

  From 01 Apr. 2007, To 31 Mar. 2012, Project Closed

  人工免疫組織;人工リンパ節;ストローマ細胞;インデューサー細胞;抗原特異的二次免疫反応;感染防御;腫瘍免疫;人工脾臓;生体適合材料;抗体産生;ヒト化マウス;メモリー細胞;免疫学;再生医学;感染症;バイオテクノロジー;人工組織;濾胞性ヘルパーT細胞;リンパ節;再生医療;感染症治療;モノクローナル抗体;免疫組織再生;癌治療

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-19059015/
• ヒト型人工リンパ組織構築法の開発及びヒト免疫反応検出系への応用

  Grant-in-Aid for Scientific Research (C)

  Basic Section 42040:Laboratory animal science-related

  Kyoto University

  小林 由佳

  From 01 Apr. 2024, To 31 Mar. 2027, Granted

  人工リンパ組織;ヒト化マウス;ヒト免疫細胞;ストローマ細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K09297/